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Conserved domains on  [gi|1720434751|ref|XP_030107119|]
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plexin-A3 isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 732-1275 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


:

Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 930.84  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  732 QIPFLDYRTYAVRVLFPGIEAHPVLKELDTPP-------NVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVA 804
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPVtndgrrtNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  805 SLTMVALQSRLDYATGLLKQLLADLIEKNLESKNhPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQ 884
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVESKN-PKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQ 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  885 QMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPESEGSAQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPK 964
Cdd:pfam08337  160 QVEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEGENSESVPVKVLDCDTITQVKEKILDAIYKNTPYSQRPS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  965 AEDMDLEWRQGRMARIILQDEDITTKIECDWKRVNSLAHYQVTDGSLVALVPkqvsaynmansftftrslsryesllraa 1044
Cdd:pfam08337  240 IDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP---------------------------- 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1045 sspdslrsrapmltpdqeagtKLWHLVRNHDHTDHREG-DRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHrgS 1123
Cdd:pfam08337  292 ---------------------KYWHLVKPSDEGDQRKKsERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVPN--S 348

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1124 ALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEH 1203
Cdd:pfam08337  349 ALPLAVKYLFDFLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEH 428

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720434751 1204 RLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTK 1275
Cdd:pfam08337  429 RLGKDSPSNKLLYAKDIPRYKQMVERYYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 462-562 1.76e-43

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238586  Cd Length: 99  Bit Score: 152.96  E-value: 1.76e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  462 PTVTHLEPTWSIINGSTSITVSGTHLLTVQEPRVRAKYRGIETTnTCQVINDTAMLCKAPGIFLGhPQPRAQGEHPDEFG 541
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVEKT-SCKVRNSTLMTCPAPSLALL-NRSPEPGERPVEFG 78

                           90       100
                   ....*....|....*....|.
gi 1720434751  542 FLLDHVQAARSLNRSSFTYYP 562
Cdd:cd01181     79 LDGDNVQSLLILNRTSFSYYP 99
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 129-223 3.51e-34

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


:

Pssm-ID: 465619  Cd Length: 94  Bit Score: 126.24  E-value: 3.51e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  129 GDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQHRVPAVRFNSSSVQCQNASYFYEGDEfGDTELDFSVVWDG 208
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDSITCQEHQFSYSGSS-GELPATFYVTWNG 79

                           90
                   ....*....|....*
gi 1720434751  209 DFPIDKPPSFRALLY 223
Cdd:pfam18020   80 GHRLDNPANLQVVLY 94
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 279-373 2.82e-33

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238585  Cd Length: 94  Bit Score: 123.96  E-value: 2.82e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  279 PRITQIHPLTGPKEGGTRVTIVGENLGL--TSREVGLRVAGVRCNSIPTEYVSAERIVCEMEESLVPsPPPGPAELCVGD 356
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLrkNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNP-VFNGPVEVTVGH 79

                           90
                   ....*....|....*..
gi 1720434751  357 CSadFRTQSQQLYSFVT 373
Cdd:cd01180     80 GS--FRTESSEGFSFVD 94
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 374-460 5.94e-27

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238584  Cd Length: 85  Bit Score: 105.38  E-value: 5.94e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  374 PTFDRVSPSRGPASGGTRLTISGISLDAGSRVTVIIRDGECQFVRRDAEAIVCISPVSTLgPSQSPITLAIDHANIsNTG 453
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSAS-PGEAPVKVLIDGARR-LAP 78


                   ....*..
gi 1720434751  454 VIYTYTQ 460
Cdd:cd01179     79 LVFTYTE 85
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 1-75 8.11e-17

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


:

Pssm-ID: 465588  Cd Length: 89  Bit Score: 76.54  E-value: 8.11e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720434751    1 MRNVPDLSVGVSCSFEEVTESEAILLpSGELRCPSPSLQELQTLTRGHGaTHTVRLQLLSMETGVRFAGVDFVFY 75
Cdd:pfam17960   17 VPNLPALSEGYSCVFGDLTESPATVH-DNGVKCATPPPSQLPPIPTGQD-HVTVKLSLRSSETGVDFASTNFTFY 89
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 227-276 1.02e-09

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 55.41  E-value: 1.02e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720434751  227 AQRPSCGLCLKADpRFNCGWCISEHRCQLRAHCPAPKSNWMHPSQKGARC 276
Cdd:pfam01437    3 SQYTSCSSCLAAR-DPYCGWCSSEGRCVRRSACGAPEGNCEEWEQASSKC 51
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 76-123 3.79e-09

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 53.87  E-value: 3.79e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720434751   76 NCSALQSCMSCVGSPYP-CHWCKYRHVCTsHPHECSFQEGR----VHSPEGCP 123
Cdd:pfam01437    1 RCSQYTSCSSCLAARDPyCGWCSSEGRCV-RRSACGAPEGNceewEQASSKCP 52
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 564-647 9.94e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 50.92  E-value: 9.94e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  564 PSFEPLGPS-GVLDvkPGSHVVLKGKNLipaaaGSSRLNYTVLIGGQPCALT-VSDTQLLCDSPSQT--GRQPVMVLVGG 639
Cdd:cd00603      1 PVITSISPSsGPLS--GGTRLTITGSNL-----GSGSPRVRVTVGGVPCKVLnVSSTEIVCRTPAAAtpGEGPVEVTVDG 73


                   ....*...
gi 1720434751  640 LEFWLGTL 647
Cdd:cd00603     74 ANVSARVL 81
 
Name Accession Description Interval E-value
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 732-1275 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 930.84  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  732 QIPFLDYRTYAVRVLFPGIEAHPVLKELDTPP-------NVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVA 804
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPVtndgrrtNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  805 SLTMVALQSRLDYATGLLKQLLADLIEKNLESKNhPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQ 884
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVESKN-PKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQ 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  885 QMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPESEGSAQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPK 964
Cdd:pfam08337  160 QVEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEGENSESVPVKVLDCDTITQVKEKILDAIYKNTPYSQRPS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  965 AEDMDLEWRQGRMARIILQDEDITTKIECDWKRVNSLAHYQVTDGSLVALVPkqvsaynmansftftrslsryesllraa 1044
Cdd:pfam08337  240 IDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP---------------------------- 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1045 sspdslrsrapmltpdqeagtKLWHLVRNHDHTDHREG-DRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHrgS 1123
Cdd:pfam08337  292 ---------------------KYWHLVKPSDEGDQRKKsERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVPN--S 348

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1124 ALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEH 1203
Cdd:pfam08337  349 ALPLAVKYLFDFLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEH 428

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720434751 1204 RLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTK 1275
Cdd:pfam08337  429 RLGKDSPSNKLLYAKDIPRYKQMVERYYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
RasGAP_plexin_A cd12790
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of ...
 732-1304 0e+00

Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. They are divided into four types (A-D) according to sequence similarity. In vertebrates, there are four type A plexins (A1-A4) that serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin-D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 1 and class 6 semaphorins signal through type A plexins, which mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a and Plexin-A mediated axon repulsion. In their complex with Sema6s, type A plexins serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin-A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213350 [Multi-domain]  Cd Length: 385  Bit Score: 751.56  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  732 QIPFLDYRTYAVRVLFPGIEAHPVLKEL----DTPPNVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVASLT 807
Cdd:cd12790      1 GIPFLDYRTYAMRVLFPGIEDHPVLRELeverDRQENVEKGLRLFGQLLMNKTFLLTFIRTLESQRSFSMRDRGNVASLI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  808 MVALQSRLDYATGLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQME 887
Cdd:cd12790     81 MVVLQSKMEYATDILKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFMLFCAIKQQME 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  888 KGPIdaitgearyslsedklirqqidyktltlhcvcpesegsaqvpvkvlncDSItqakdklldtvykgipysqrpkaed 967
Cdd:cd12790    161 KGPI------------------------------------------------DAI------------------------- 167

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  968 mdlewrqgrmariilqdedittkiecdwkrvnslahyqvtdgslvalvpkqvsaynmansftftrslsryesllraassp 1047
Cdd:cd12790        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1048 dslrsrapmltpdqeagtklwhlvrnhdhtdhregdrgsKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRGSALPL 1127
Cdd:cd12790    168 ---------------------------------------KMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPL 208

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1128 AIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGK 1207
Cdd:cd12790    209 AIKYMFDFLDEQADQHGITDPEVVHTWKSNCLPLRFWVNLIKNPQFVFDIHKSSITDACLSVVAQTFMDSCSTSEHRLGK 288

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1208 DSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTSLDRD 1287
Cdd:cd12790    289 DSPSNKLLYAKDIPNYKSWVERYYADIAKMPAISDQDMNAYLAEQSRLHLNEFNTLSALNELYSYVTKYKEEILTALEED 368

                          570
                   ....*....|....*..
gi 1720434751 1288 ASCRKHKLRQKLEQIIT 1304
Cdd:cd12790    369 EFARKQRLAYKLEQVIN 385
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 462-562 1.76e-43

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 152.96  E-value: 1.76e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  462 PTVTHLEPTWSIINGSTSITVSGTHLLTVQEPRVRAKYRGIETTnTCQVINDTAMLCKAPGIFLGhPQPRAQGEHPDEFG 541
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVEKT-SCKVRNSTLMTCPAPSLALL-NRSPEPGERPVEFG 78

                           90       100
                   ....*....|....*....|.
gi 1720434751  542 FLLDHVQAARSLNRSSFTYYP 562
Cdd:cd01181     79 LDGDNVQSLLILNRTSFSYYP 99
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 129-223 3.51e-34

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


Pssm-ID: 465619  Cd Length: 94  Bit Score: 126.24  E-value: 3.51e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  129 GDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQHRVPAVRFNSSSVQCQNASYFYEGDEfGDTELDFSVVWDG 208
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDSITCQEHQFSYSGSS-GELPATFYVTWNG 79

                           90
                   ....*....|....*
gi 1720434751  209 DFPIDKPPSFRALLY 223
Cdd:pfam18020   80 GHRLDNPANLQVVLY 94
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 279-373 2.82e-33

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 123.96  E-value: 2.82e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  279 PRITQIHPLTGPKEGGTRVTIVGENLGL--TSREVGLRVAGVRCNSIPTEYVSAERIVCEMEESLVPsPPPGPAELCVGD 356
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLrkNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNP-VFNGPVEVTVGH 79

                           90
                   ....*....|....*..
gi 1720434751  357 CSadFRTQSQQLYSFVT 373
Cdd:cd01180     80 GS--FRTESSEGFSFVD 94
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 374-460 5.94e-27

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 105.38  E-value: 5.94e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  374 PTFDRVSPSRGPASGGTRLTISGISLDAGSRVTVIIRDGECQFVRRDAEAIVCISPVSTLgPSQSPITLAIDHANIsNTG 453
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSAS-PGEAPVKVLIDGARR-LAP 78


                   ....*..
gi 1720434751  454 VIYTYTQ 460
Cdd:cd01179     79 LVFTYTE 85
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 1-75 8.11e-17

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 76.54  E-value: 8.11e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720434751    1 MRNVPDLSVGVSCSFEEVTESEAILLpSGELRCPSPSLQELQTLTRGHGaTHTVRLQLLSMETGVRFAGVDFVFY 75
Cdd:pfam17960   17 VPNLPALSEGYSCVFGDLTESPATVH-DNGVKCATPPPSQLPPIPTGQD-HVTVKLSLRSSETGVDFASTNFTFY 89
IPT smart00429
ig-like, plexins, transcription factors;
374-459 4.21e-16

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 74.76  E-value: 4.21e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751   374 PTFDRVSPSRGPASGGTRLTISGISLDAGSRVTVIIRDGE--CQFVRRDAEAIVCISPVSTLGPSQSPI-TLAIDHANIS 450
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEapCTFSPSSSTAIVCKTPPYHNIPGSVPVrTVGLRNGGVP 81


                    ....*....
gi 1720434751   451 NTGVIYTYT 459
Cdd:smart00429   82 SSPQPFTYV 90
IPT smart00429
ig-like, plexins, transcription factors;
279-369 4.83e-14

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 68.99  E-value: 4.83e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751   279 PRITQIHPLTGPKEGGTRVTIVGENLG-LTSREVGLRVAGVRCNSIPTeyvSAERIVCEMeeslvPSPPPGPAEL---CV 354
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKsISVVFVEVGVGEAPCTFSPS---SSTAIVCKT-----PPYHNIPGSVpvrTV 73

                            90
                    ....*....|....*
gi 1720434751   355 GDCSADFRTQSQQLY 369
Cdd:smart00429   74 GLRNGGVPSSPQPFT 88
IPT smart00429
ig-like, plexins, transcription factors;
461-561 2.56e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 66.68  E-value: 2.56e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751   461 DPTVTHLEPTWSIINGSTSITVSGTHLLTVQEPRVRAKYRGIEttntCQVIND--TAMLCKAPgiflghPQPRAQGEHP- 537
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAP----CTFSPSssTAIVCKTP------PYHNIPGSVPv 70

                            90       100
                    ....*....|....*....|....
gi 1720434751   538 DEFGFLLDHVQAarslNRSSFTYY 561
Cdd:smart00429   71 RTVGLRNGGVPS----SPQPFTYV 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 279-368 4.77e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 62.85  E-value: 4.77e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  279 PRITQIHPLTGPKEGGTRVTIVGENLGLTSREVGLRVAGVRCNSIpteYVSAERIVCEmeeslVPSPPPGPAELCVGDCS 358
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVI---SVSSTTIVCT-----TPPGTSGLVNVSVTVGG 72

                           90
                   ....*....|
gi 1720434751  359 ADFRTQSQQL 368
Cdd:pfam01833   73 GGISSSPLTF 82
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 374-458 8.48e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.38  E-value: 8.48e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  374 PTFDRVSPSRGPASGGTRLTISGISLDAGSR-VTVIIRDGECQFVRRDAEAIVCISPVSTlgPSQSPITLAIDHANISNT 452
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSdLKVTIGGTPCTVISVSSTTIVCTTPPGT--SGLVNVSVTVGGGGISSS 78


                   ....*.
gi 1720434751  453 GVIYTY 458
Cdd:pfam01833   79 PLTFTY 84
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 227-276 1.02e-09

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 55.41  E-value: 1.02e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720434751  227 AQRPSCGLCLKADpRFNCGWCISEHRCQLRAHCPAPKSNWMHPSQKGARC 276
Cdd:pfam01437    3 SQYTSCSSCLAAR-DPYCGWCSSEGRCVRRSACGAPEGNCEEWEQASSKC 51
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 76-123 3.79e-09

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 53.87  E-value: 3.79e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720434751   76 NCSALQSCMSCVGSPYP-CHWCKYRHVCTsHPHECSFQEGR----VHSPEGCP 123
Cdd:pfam01437    1 RCSQYTSCSSCLAARDPyCGWCSSEGRCV-RRSACGAPEGNceewEQASSKCP 52
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
227-268 7.16e-09

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 52.93  E-value: 7.16e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1720434751   227 AQRPSCGLCLKADPrFNCGWCISEHRCQLRAHCPAPKSNWMH 268
Cdd:smart00423    3 SKYTSCSECLLARD-PYCAWCSSQGRCTSGERCDSRRQNWLS 43
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
76-123 1.98e-08

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 51.39  E-value: 1.98e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1720434751    76 NCSALQSCMSCVGSPYP-CHWCKYRHVCTsHPHECSFQEGRVhSPEGCP 123
Cdd:smart00423    1 RCSKYTSCSECLLARDPyCAWCSSQGRCT-SGERCDSRRQNW-LSGGCP 47
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 564-647 9.94e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 50.92  E-value: 9.94e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  564 PSFEPLGPS-GVLDvkPGSHVVLKGKNLipaaaGSSRLNYTVLIGGQPCALT-VSDTQLLCDSPSQT--GRQPVMVLVGG 639
Cdd:cd00603      1 PVITSISPSsGPLS--GGTRLTITGSNL-----GSGSPRVRVTVGGVPCKVLnVSSTEIVCRTPAAAtpGEGPVEVTVDG 73


                   ....*...
gi 1720434751  640 LEFWLGTL 647
Cdd:cd00603     74 ANVSARVL 81
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 580-650 2.29e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 43.97  E-value: 2.29e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720434751  580 GSHVVLKGKNLipaaaGSSRLNYTVLIGGQPCA-LTVSDTQLLCDSPSQT-GRQPVMVLVGGLEFWLGTLHIT 650
Cdd:pfam01833   16 GTTITITGSNF-----GTDSSDLKVTIGGTPCTvISVSSTTIVCTTPPGTsGLVNVSVTVGGGGISSSPLTFT 83
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 462-560 5.51e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 40.12  E-value: 5.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  462 PTVTHLEPTWSIINGSTSITVSGTHLLTVQEpRVRAKYRGIETTNTcqVINDTAMLCKAPgiflghpqPRAQGEHPdefg 541
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSS-DLKVTIGGTPCTVI--SVSSTTIVCTTP--------PGTSGLVN---- 65

                           90
                   ....*....|....*....
gi 1720434751  542 FLLDHVQAARSLNRSSFTY 560
Cdd:pfam01833   66 VSVTVGGGGISSSPLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
563-633 7.45e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 39.71  E-value: 7.45e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720434751   563 DPSFEPLGPSGVLdVKPGSHVVLKGKNLIPAAAGSSRLNYtvliGGQPCALT-VSDTQLLCDSPSQT---GRQPV 633
Cdd:smart00429    1 DPVITRISPTSGP-VSGGTEITLCGKNLKSISVVFVEVGV----GEAPCTFSpSSSTAIVCKTPPYHnipGSVPV 70
 
Name Accession Description Interval E-value
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 732-1275 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 930.84  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  732 QIPFLDYRTYAVRVLFPGIEAHPVLKELDTPP-------NVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVA 804
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPVtndgrrtNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  805 SLTMVALQSRLDYATGLLKQLLADLIEKNLESKNhPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQ 884
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVESKN-PKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQ 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  885 QMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPESEGSAQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPK 964
Cdd:pfam08337  160 QVEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEGENSESVPVKVLDCDTITQVKEKILDAIYKNTPYSQRPS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  965 AEDMDLEWRQGRMARIILQDEDITTKIECDWKRVNSLAHYQVTDGSLVALVPkqvsaynmansftftrslsryesllraa 1044
Cdd:pfam08337  240 IDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP---------------------------- 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1045 sspdslrsrapmltpdqeagtKLWHLVRNHDHTDHREG-DRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHrgS 1123
Cdd:pfam08337  292 ---------------------KYWHLVKPSDEGDQRKKsERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVPN--S 348

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1124 ALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEH 1203
Cdd:pfam08337  349 ALPLAVKYLFDFLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEH 428

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720434751 1204 RLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTK 1275
Cdd:pfam08337  429 RLGKDSPSNKLLYAKDIPRYKQMVERYYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
RasGAP_plexin_A cd12790
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of ...
 732-1304 0e+00

Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. They are divided into four types (A-D) according to sequence similarity. In vertebrates, there are four type A plexins (A1-A4) that serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin-D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 1 and class 6 semaphorins signal through type A plexins, which mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a and Plexin-A mediated axon repulsion. In their complex with Sema6s, type A plexins serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin-A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213350 [Multi-domain]  Cd Length: 385  Bit Score: 751.56  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  732 QIPFLDYRTYAVRVLFPGIEAHPVLKEL----DTPPNVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVASLT 807
Cdd:cd12790      1 GIPFLDYRTYAMRVLFPGIEDHPVLRELeverDRQENVEKGLRLFGQLLMNKTFLLTFIRTLESQRSFSMRDRGNVASLI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  808 MVALQSRLDYATGLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQME 887
Cdd:cd12790     81 MVVLQSKMEYATDILKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFMLFCAIKQQME 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  888 KGPIdaitgearyslsedklirqqidyktltlhcvcpesegsaqvpvkvlncDSItqakdklldtvykgipysqrpkaed 967
Cdd:cd12790    161 KGPI------------------------------------------------DAI------------------------- 167

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  968 mdlewrqgrmariilqdedittkiecdwkrvnslahyqvtdgslvalvpkqvsaynmansftftrslsryesllraassp 1047
Cdd:cd12790        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1048 dslrsrapmltpdqeagtklwhlvrnhdhtdhregdrgsKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRGSALPL 1127
Cdd:cd12790    168 ---------------------------------------KMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPL 208

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1128 AIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGK 1207
Cdd:cd12790    209 AIKYMFDFLDEQADQHGITDPEVVHTWKSNCLPLRFWVNLIKNPQFVFDIHKSSITDACLSVVAQTFMDSCSTSEHRLGK 288

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1208 DSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTSLDRD 1287
Cdd:cd12790    289 DSPSNKLLYAKDIPNYKSWVERYYADIAKMPAISDQDMNAYLAEQSRLHLNEFNTLSALNELYSYVTKYKEEILTALEED 368

                          570
                   ....*....|....*..
gi 1720434751 1288 ASCRKHKLRQKLEQIIT 1304
Cdd:cd12790    369 EFARKQRLAYKLEQVIN 385
RasGAP_plexin cd12205
Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane ...
 732-1303 0e+00

Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes, including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Other proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213344 [Multi-domain]  Cd Length: 382  Bit Score: 549.13  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  732 QIPFLDYRTYAVRVLFPGIEAHPVLKELDTP----PNVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVASLT 807
Cdd:cd12205      1 GIPFLDFREYIIRVLFPGVNDHPVLLSKFVHgsrrPDLEDALSQFEQLLCNKQFLLTFIRTLESQPKFSSRDKCNVASLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  808 MVALQSRLDYATGLLKQLLADLIEKNLeSKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQME 887
Cdd:cd12205     81 MVALQGKMEYATEILFDLLTDLIEKSV-SKKHPKLMLRRTESVVEKLLTNWLSLCLYDYLKETAGEPLFLLYKALKQQIE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  888 KGPidaitgearyslsedklirqqidyktltlhcvcpesegsaqvpvkvlnCDSItqakdklldtvykgipysqrpkaed 967
Cdd:cd12205    160 KGP------------------------------------------------VDAI------------------------- 166

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  968 mdlewrqgrmariilqdedittkiecdwkrvnslahyqvtdgslvalvpkqvsaynmansftftrslsryesllraassp 1047
Cdd:cd12205        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1048 dslrsrapmltpdqeagtklwhlvrnhdhtdhregdrgsKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRgsALPL 1127
Cdd:cd12205    167 ---------------------------------------KLIPEIFLTRLLSTKGTLQKFVDDLFESILSVPQR--SLPP 205

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1128 AIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGK 1207
Cdd:cd12205    206 AIKYLFDFLDEQARKHGISDPDVLHAWKTNSLPLRFWVNIIKNPDFVFDVNKTPTVDSCLSVIAQTFMDACSTSEHKLGK 285

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1208 DSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTSLDRD 1287
Cdd:cd12205    286 DSPSNKLLFAKDIPRYREMVANFYRDISNLPPVSDEEMNSYLAELSESHSGEFNTNVALSELYIYAVKYGDQLLEALEDD 365

                          570
                   ....*....|....*.
gi 1720434751 1288 ASCRKHKLRQKLEQII 1303
Cdd:cd12205    366 REARVQQLADKLSQVA 381
RasGAP_plexin_B cd12787
Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of ...
 733-1306 5.11e-137

Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity.There are three members of the Plexin-B subfamily, namely B1, B2 and B3. Plexins-B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin-B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin-B signaling. Plexin-B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin-B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213347 [Multi-domain]  Cd Length: 391  Bit Score: 423.96  E-value: 5.11e-137
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  733 IPFLDYRTYAVRVLFPGIEAHP--VLKELDTP----PNVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVASL 806
Cdd:cd12787      2 IPFLDYKTYAERVFFPGHKDGPldVMIKLDIPeprrPTVEQGLYQLSNLLNSKLFLINFIHTLENQREFSARDRVYVASL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  807 TMVALQSRLDYATGLLKQLLADLIEKNLeSKNhPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQM 886
Cdd:cd12787     82 LTVALHGKLEYYTDIMRTLLLDLLAQYV-VKN-PKLMLRRTETVVEKLLTNWMSICLYQFLRDSAGEPLYMLFRAIKHQV 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  887 EKGPIDAITGearyslsedklirqqidyktltlhcvcpesegsaqvpvkvlncdsitqakdklldtvykgipysqrpkae 966
Cdd:cd12787    160 DKGPVDAVTG---------------------------------------------------------------------- 169

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  967 dmdlewrqgrmariilqdedittkiecdwKRvnslahyqvtdgslvalvpkqvsaynmansftftrslsryesllraass 1046
Cdd:cd12787    170 -----------------------------KR------------------------------------------------- 171

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1047 pdslrsrapmltpdqeagtklwhlvrnhdhtdhregdrgSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHrgsALP 1126
Cdd:cd12787    172 ---------------------------------------AKAIPEIYLTRLLSMKGTLQKFVDDFFQSILSPGR---PVP 209

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1127 LAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLG 1206
Cdd:cd12787    210 PAVKYFFDLLDEQAEKHGIQDEDTIHIWKTNSLPLRFWVNILKNPQFIFDVHVSDNVDASLSVIAQTFMDACTRTEHKLG 289

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1207 KDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTSLDR 1286
Cdd:cd12787    290 RDSPSNKLLYAREIPRYKKMVERYYADIRQMVPASDQEMNSHLAELSRNYTDSLNTLVALHELYQYIQKYYDQIINALEE 369

                          570       580
                   ....*....|....*....|
gi 1720434751 1287 DASCRKHKLRQKLEQIITLV 1306
Cdd:cd12787    370 DPAAQKMQLAFRLQQIAAAV 389
RasGAP_plexin_D1 cd12788
Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane ...
 733-1306 1.72e-131

Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. The Plexin-D1 and Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213348 [Multi-domain]  Cd Length: 419  Bit Score: 410.54  E-value: 1.72e-131
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  733 IPFLDYRTYAVRVLFPGI------------------------EAHPVLKELDTP----PNVEKALRLFGQLLHSRAFLLT 784
Cdd:cd12788      3 IPFLEYKHFVTRTFFPKCsslyeeryvlpsqennsqgprqvpETHPLLQEWKIPescrPNMEEGITLFSTLLNNKHFLVT 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  785 FIHTLEAQSSFSMRDRGTVASLTMVALQSRLDYATGLLKQLLADLIEKNlESKNhPKLLLRRTESVAEKMLTNWFTFLLH 864
Cdd:cd12788     83 FVHALEQQKDFAVRDRCNLASLLTIALHGKLEYYTSIMKDLLVDLIDAS-ASKN-PKLMLRRTESVVEKMLTNWMSICMY 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  865 KFLKECAGEPLFLLYCAIKQQMEKGPIDAITgearyslsedklirqqidyktltlhcvcpesegsaqvpvKVLncdsitq 944
Cdd:cd12788    161 SYLRETVGEPFFLLLCAIKQQINKGSIDAIK---------------------------------------KVL------- 194

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  945 akdklldtvykgipysqrpkaedmdlewrqgrmariilqdedittkiecdwkrvnslahyqvtdgslvalvpkqvsaynm 1024
Cdd:cd12788        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1025 ansftftrslsryesllraasspdslrsrapmltpdqeagtklwhlvrnhdhtdhregdrgskmvSEIYLTRLLATKGTL 1104
Cdd:cd12788    195 -----------------------------------------------------------------PEIYLTRLLSTKGTL 209

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1105 QKFVDDLFETVFSTahRGSALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITD 1184
Cdd:cd12788    210 QKFLDDLFQAILSI--PEDRPPLAVKYFFDFLEEQAEKRGITDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKTDHMD 287

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1185 ACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLS 1264
Cdd:cd12788    288 ACLSVIAQAFIDACSISDLQLGKDSPTNKLLYAKEIPEYRKIVQRYYQQIQEMPPLSEQEMNAHLAEESRKYRNEFNTNV 367

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|..
gi 1720434751 1265 ALSELYFYVTKYRQEILTSLDRDASCRKHKLRQKLEQIITLV 1306
Cdd:cd12788    368 AMAEIYKYAKRYRAQIVSALESNPTARRTQLQHKFEQVIALM 409
RasGAP_plexin_B1 cd12793
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane ...
 733-1308 6.19e-131

Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D and plexin-B1 signaling complex regulates dendritic and axonal complexity. The activation of Plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin-B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin-B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin-B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213353 [Multi-domain]  Cd Length: 394  Bit Score: 407.88  E-value: 6.19e-131
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  733 IPFLDYRTYAVRVLFPGIEAHPVLKELDTP----PNVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVASLTM 808
Cdd:cd12793      2 IPFLDYRMYAERIFFPGHRESPLRRDLDVPecrrQTVEQGLVQLSNLLNSKLFLTKFIHTLESQRTFSPRDRAYVASLLT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  809 VALQSRLDYATGLLKQLLADLIEKNLeSKNhPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQMEK 888
Cdd:cd12793     82 VALHGKLEYFTDILKTLLNDLVEQYV-AKN-PKLMLRRTETVVEKLLTNWMSICLYTFLRDSAGESLYMLFRAIKHQVDK 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  889 GPIDAITGEARyslsedklirqqidyktltlhcvcpesegsaqvpvkvlncdsitqakdklldtvykgipysqrpkaedm 968
Cdd:cd12793    160 GPVDAVTGKER--------------------------------------------------------------------- 170

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  969 dlewrqgrmariilqdedittkiecdwkrvnslahyqvtdgslvalvpkqvsaynmansftftrslsryesllraasspd 1048
Cdd:cd12793        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1049 slrsrapmltpdqeagtklwhlvrnhdhtdhregdrgSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHrgsALPLA 1128
Cdd:cd12793    171 -------------------------------------AKAIPEIYLTRLLSMKGTLQKFVDDLFTVILSTSR---PVPLA 210

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1129 IKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKD 1208
Cdd:cd12793    211 VKYFFDLLDEQALQHGISDPETIHIWKTNSLPLRFWINIIKNPQFIFDVQTSDNVDAVLSVIAQTFMDSCTIADHKLGRD 290

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1209 SPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTSLDRDA 1288
Cdd:cd12793    291 SPINKLLYARDIPRYKQMVERYYADIRQTVSASDQEMNSALAELSRNYSGELNYLVALHELYKYINKYYDQIITALEEDS 370

                          570       580
                   ....*....|....*....|
gi 1720434751 1289 SCRKHKLRQKLEQIITLVSS 1308
Cdd:cd12793    371 TAQKMQLGYRLQQIAAAVEN 390
RasGAP_plexin_B3 cd12791
Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane ...
 733-1306 1.74e-129

Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin-B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The protein and mRNA expression of Sema5A and its receptor plexin-B3 increased gradually in non-neoplastic mucosa, primary gastric carcinoma, and lymph node metastasis, and their expression is correlated. The stimulation of plexin-B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213351 [Multi-domain]  Cd Length: 397  Bit Score: 404.22  E-value: 1.74e-129
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  733 IPFLDYRTYAVRVLFPGIEAHPVLKELDTP------PNVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVASL 806
Cdd:cd12791      2 IPFLDYRTYAERVFFPGHGGCPLQPSLEGDgeegrrATVEQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVASL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  807 TMVALQSRLDYATGLLKQLLADLIEKNLeSKNhPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQM 886
Cdd:cd12791     82 LSLALHGKLEYLTDIMKTLLGDLAAHYV-HKN-PKLMLRRTETMVEKLLTNWMSICLYAFLREVAGEPLYMLFRAIKYQV 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  887 EKGPIDAITGEaryslsedklirqqidyktltlhcvcpesegsaqvpvkvlncdsitqakdklldtvykgipysqrpkae 966
Cdd:cd12791    160 DKGPVDAVTGK--------------------------------------------------------------------- 170

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  967 dmdlewrqgrmariilqdedittkiecdwkrvnslahyqvtdgslvalvpkqvsaynmansftftrslsryesllraass 1046
Cdd:cd12791        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1047 pdslRSRApmltpdqeagtklwhlvrnhdhtdhregdrgsKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTahrGSALP 1126
Cdd:cd12791    171 ----RERA--------------------------------KAIPEIYLTRLLSMKGTLQKFVDDTFQAILSV---NRPVP 211

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1127 LAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLG 1206
Cdd:cd12791    212 IAVKYLFDFLDELAEKHGIEDPETLHIWKTNSLLLRFWVNTLKNPQFIFDVRVSDNVDAILAVIAQTFIDSCTISEHKVG 291

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1207 KDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTSLDR 1286
Cdd:cd12791    292 RDSPVNKLLYAREIPRYKQMVEKYYADIRQSSPASYQEMNSALTELSGNYTSAPHCLVALQELYNHIHRYYDQIISALEE 371

                          570       580
                   ....*....|....*....|
gi 1720434751 1287 DASCRKHKLRQKLEQIITLV 1306
Cdd:cd12791    372 DPVGQKMQLACRLQQIAALV 391
RasGAP_plexin_B2 cd12792
Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane ...
 732-1302 3.55e-123

Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Mice lacking Plexin-B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C and Plexin-B2 signaling modulates ureteric branching. Plexin-B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin-B2 results in renal hypoplasia and occasional double ureters. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213352 [Multi-domain]  Cd Length: 400  Bit Score: 387.44  E-value: 3.55e-123
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  732 QIPFLDYRTYAVRVLF----PGIEAHPVLKELDTP----PNVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTV 803
Cdd:cd12792      1 RIPFLDYKTYTDRVFFlpskDGANDVMITGKLDIPearrATVEQALNQFSNLLNSKTFLINFIHTLENQRDFNARAKVYF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  804 ASLTMVALQSRLDYATGLLKQLLADLIEKNLESKNhPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIK 883
Cdd:cd12792     81 ASLLTVALHGKLEYYTDIMRTLLLELMEQYVHSKN-PKLMLRRSETVVERMLSNWMSICLYQYLKDTAGEPLYKLFKAIK 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  884 QQMEKGPIDAitgearyslsedklirqqidyktltlhcvcpesegsaqvpvkvlncdsitqakdklldtvykgipysqrp 963
Cdd:cd12792    160 HQVEKGPVDA---------------------------------------------------------------------- 169

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  964 kaedmdlewRQGRMARiilqdedittkiecdwkrvnslahyqvtdgslvalvpkqvsaynmansftftrslsryesllra 1043
Cdd:cd12792    170 ---------VQKKKER---------------------------------------------------------------- 176

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1044 asspdslrsrapmltpdqeagtklwhlvrnhdhtdhregdrgSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTahrGS 1123
Cdd:cd12792    177 ------------------------------------------TKAITEIYLTRLLSVKGTLQQFVDNFFRSVLCS---GA 211

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1124 ALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEH 1203
Cdd:cd12792    212 VVPPAVKYFFDFLDEQAEKHDIVDEETIHIWKTNSLPLRFWVNILKNPHFIFDVHVTEVVDASLSVIAQTFMDACTKTEH 291

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1204 RLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTS 1283
Cdd:cd12792    292 KLSRDSPSNKLLYAKEISTYKKMVDDYYKGIRQMVPVSDQDMNTHLAEISRAHTDKLNTQVALHQLYQYASKYYDEIINS 371

                          570
                   ....*....|....*....
gi 1720434751 1284 LDRDASCRKHKLRQKLEQI 1302
Cdd:cd12792    372 LEEDPAAQSKQLTLRLQQI 390
RasGAP_plexin_C1 cd12789
Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane ...
 733-1306 5.22e-99

Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-C1 has been identified as the receptor of semaphorin 7A, which plays regulatory roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin-C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin-C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A and Plexin-C1 signaling. Melanoma invasion and metastasis may be promoted through the loss of Plexin-C1 inhibitory signaling on cofilin activation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213349 [Multi-domain]  Cd Length: 393  Bit Score: 321.81  E-value: 5.22e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  733 IPFLDYRTYAVRVLFPGIEAHPVLKELDTPPN-----VEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVASLT 807
Cdd:cd12789      4 VPFLDYKHFALRTFFPESGGFTHIFTRDDPHDrdqtdKDESLTALDKLICNKSFLVTLIHTLEKQKNFSVKDRCLFASFL 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  808 MVALQSRLDYATGLLKQLLADLIEKNleSKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQME 887
Cdd:cd12789     84 TIALQTKLVYLTEILEVLTKDLMDQS--SNAQPKLLLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKIN 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  888 KGPIDAItgearyslsedklirqqidyktltlhcvcpesegsaqvpvkvlncdsitqakdklldtvykgipysqRPKAED 967
Cdd:cd12789    162 KGPVDVI-------------------------------------------------------------------KFKVKE 174

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  968 MDLewrqgrmariilqdedittkiecdwkrvnslahyqvtdgslvalvpkqvsaynmansftftrslsryesllraassp 1047
Cdd:cd12789    175 MYL----------------------------------------------------------------------------- 177

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1048 dslrsrapmltpdqeagTKLwhlvrnhdhtdhregdrgskmvseiyltrlLATKGTLQKFVDDLFETVFSTAHrgSALPL 1127
Cdd:cd12789    178 -----------------TKL------------------------------LSTKVAIHSVVEKLFRSIWSLPN--NKAPV 208

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1128 AIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGK 1207
Cdd:cd12789    209 AIKYFFDFLDAQAENKKITDPDVLHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHLDGCLSVIAQAFMDSFSLSEQHLGK 288

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1208 DSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTSLDRD 1287
Cdd:cd12789    289 EAPTNKLLYAKDIPQYKEEVKSYYKAIRDLPPLSSSELEEFLTQESKKHENEFNEEVALMEIYKYIVKYFDEILNKLERE 368

                          570
                   ....*....|....*....
gi 1720434751 1288 ASCRkhKLRQKLEQIITLV 1306
Cdd:cd12789    369 RGLE--EVQKQLLHVKALF 385
Plexin_RBD pfam20170
Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding ...
 902-1014 3.74e-61

Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding domain found in the cytoplasmic domain of plexins.


Pssm-ID: 466321  Cd Length: 113  Bit Score: 204.35  E-value: 3.74e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  902 LSEDKLIRQQIDYKTLTLHCVCPESEGSAQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGRMARII 981
Cdd:pfam20170    1 LSEDKLLREQIDYKTLTLNVIFEEGEVSESVPVKVLDCDTISQVKEKILDAVYKNTPYSQRPSIDDVDLEWRHGRGGRLI 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1720434751  982 LQDEDITTKIECDWKRVNSLAHYQVTDGSLVAL 1014
Cdd:pfam20170   81 LQDEDSTSKVEGGWKKLNTLAHYKVPDGATLAL 113
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 462-562 1.76e-43

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 152.96  E-value: 1.76e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  462 PTVTHLEPTWSIINGSTSITVSGTHLLTVQEPRVRAKYRGIETTnTCQVINDTAMLCKAPGIFLGhPQPRAQGEHPDEFG 541
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVEKT-SCKVRNSTLMTCPAPSLALL-NRSPEPGERPVEFG 78

                           90       100
                   ....*....|....*....|.
gi 1720434751  542 FLLDHVQAARSLNRSSFTYYP 562
Cdd:cd01181     79 LDGDNVQSLLILNRTSFSYYP 99
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 129-223 3.51e-34

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


Pssm-ID: 465619  Cd Length: 94  Bit Score: 126.24  E-value: 3.51e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  129 GDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQHRVPAVRFNSSSVQCQNASYFYEGDEfGDTELDFSVVWDG 208
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDSITCQEHQFSYSGSS-GELPATFYVTWNG 79

                           90
                   ....*....|....*
gi 1720434751  209 DFPIDKPPSFRALLY 223
Cdd:pfam18020   80 GHRLDNPANLQVVLY 94
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 279-373 2.82e-33

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 123.96  E-value: 2.82e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  279 PRITQIHPLTGPKEGGTRVTIVGENLGL--TSREVGLRVAGVRCNSIPTEYVSAERIVCEMEESLVPsPPPGPAELCVGD 356
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLrkNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNP-VFNGPVEVTVGH 79

                           90
                   ....*....|....*..
gi 1720434751  357 CSadFRTQSQQLYSFVT 373
Cdd:cd01180     80 GS--FRTESSEGFSFVD 94
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 374-460 5.94e-27

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 105.38  E-value: 5.94e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  374 PTFDRVSPSRGPASGGTRLTISGISLDAGSRVTVIIRDGECQFVRRDAEAIVCISPVSTLgPSQSPITLAIDHANIsNTG 453
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSAS-PGEAPVKVLIDGARR-LAP 78


                   ....*..
gi 1720434751  454 VIYTYTQ 460
Cdd:cd01179     79 LVFTYTE 85
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 279-372 1.32e-21

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 90.21  E-value: 1.32e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  279 PRITQIHPLTGPKEGGTRVTIVGENLGLTSREVGLRVAGVRCNSIPteyVSAERIVCEMEESlvPSPPPGPAELCVGDCS 358
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLN---VSSTEIVCRTPAA--ATPGEGPVEVTVDGAN 75

                           90
                   ....*....|....
gi 1720434751  359 ADFRTQSQQLYSFV 372
Cdd:cd00603     76 VSARVLSNTTFTYV 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 374-460 1.44e-17

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 79.04  E-value: 1.44e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  374 PTFDRVSPSRGPASGGTRLTISGISLDAGS-RVTVIIRDGECQFVRRDAEAIVCISPVSTLGPSQsPITLAIDHANIS-- 450
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSpRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEG-PVEVTVDGANVSar 79

                           90
                   ....*....|.
gi 1720434751  451 -NTGVIYTYTQ 460
Cdd:cd00603     80 vLSNTTFTYVE 90
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 1-75 8.11e-17

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 76.54  E-value: 8.11e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720434751    1 MRNVPDLSVGVSCSFEEVTESEAILLpSGELRCPSPSLQELQTLTRGHGaTHTVRLQLLSMETGVRFAGVDFVFY 75
Cdd:pfam17960   17 VPNLPALSEGYSCVFGDLTESPATVH-DNGVKCATPPPSQLPPIPTGQD-HVTVKLSLRSSETGVDFASTNFTFY 89
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 374-460 2.35e-16

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 75.58  E-value: 2.35e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  374 PTFDRVSPSRGPASGGTRLTISGISLDAGSRVTVIIRDG-ECQFVRRDAEAIVC-ISPVSTLGPSQSPITLAIDHANISN 451
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGGGvPCSVLSVSSTAIVCtTPPYANPGPGPVEVTVDRGNGGITS 80


                   ....*....
gi 1720434751  452 TGVIYTYTQ 460
Cdd:cd00102     81 SPLTFTYVP 89
IPT smart00429
ig-like, plexins, transcription factors;
374-459 4.21e-16

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 74.76  E-value: 4.21e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751   374 PTFDRVSPSRGPASGGTRLTISGISLDAGSRVTVIIRDGE--CQFVRRDAEAIVCISPVSTLGPSQSPI-TLAIDHANIS 450
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEapCTFSPSSSTAIVCKTPPYHNIPGSVPVrTVGLRNGGVP 81


                    ....*....
gi 1720434751   451 NTGVIYTYT 459
Cdd:smart00429   82 SSPQPFTYV 90
IPT smart00429
ig-like, plexins, transcription factors;
279-369 4.83e-14

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 68.99  E-value: 4.83e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751   279 PRITQIHPLTGPKEGGTRVTIVGENLG-LTSREVGLRVAGVRCNSIPTeyvSAERIVCEMeeslvPSPPPGPAEL---CV 354
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKsISVVFVEVGVGEAPCTFSPS---SSTAIVCKT-----PPYHNIPGSVpvrTV 73

                            90
                    ....*....|....*
gi 1720434751   355 GDCSADFRTQSQQLY 369
Cdd:smart00429   74 GLRNGGVPSSPQPFT 88
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 279-373 5.77e-14

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 68.64  E-value: 5.77e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  279 PRITQIHPLTGPKEGGTRVTIVGENLGLTSRevgLRV---AGVRCNSIPteyVSAERIVCEMEESlvPSPPPGPAELCVG 355
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSN---LRVtfgGGVPCSVLS---VSSTAIVCTTPPY--ANPGPGPVEVTVD 72

                           90
                   ....*....|....*...
gi 1720434751  356 DCSaDFRTQSQQLYSFVT 373
Cdd:cd00102     73 RGN-GGITSSPLTFTYVP 89
IPT smart00429
ig-like, plexins, transcription factors;
461-561 2.56e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 66.68  E-value: 2.56e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751   461 DPTVTHLEPTWSIINGSTSITVSGTHLLTVQEPRVRAKYRGIEttntCQVIND--TAMLCKAPgiflghPQPRAQGEHP- 537
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAP----CTFSPSssTAIVCKTP------PYHNIPGSVPv 70

                            90       100
                    ....*....|....*....|....
gi 1720434751   538 DEFGFLLDHVQAarslNRSSFTYY 561
Cdd:smart00429   71 RTVGLRNGGVPS----SPQPFTYV 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 279-368 4.77e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 62.85  E-value: 4.77e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  279 PRITQIHPLTGPKEGGTRVTIVGENLGLTSREVGLRVAGVRCNSIpteYVSAERIVCEmeeslVPSPPPGPAELCVGDCS 358
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVI---SVSSTTIVCT-----TPPGTSGLVNVSVTVGG 72

                           90
                   ....*....|
gi 1720434751  359 ADFRTQSQQL 368
Cdd:pfam01833   73 GGISSSPLTF 82
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 462-562 2.66e-11

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 60.93  E-value: 2.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  462 PTVTHLEPTWSIINGSTSITVSGTHLLTVQePRVRAKYRGIettnTCQVIN--DTAMLCKAPgiflGHPQPraqGEHPDE 539
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGS-PRVRVTVGGV----PCKVLNvsSTEIVCRTP----AAATP---GEGPVE 68

                           90       100
                   ....*....|....*....|...
gi 1720434751  540 FGFLLDHVQaARSLNRSSFTYYP 562
Cdd:cd00603     69 VTVDGANVS-ARVLSNTTFTYVE 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 374-458 8.48e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.38  E-value: 8.48e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  374 PTFDRVSPSRGPASGGTRLTISGISLDAGSR-VTVIIRDGECQFVRRDAEAIVCISPVSTlgPSQSPITLAIDHANISNT 452
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSdLKVTIGGTPCTVISVSSTTIVCTTPPGT--SGLVNVSVTVGGGGISSS 78


                   ....*.
gi 1720434751  453 GVIYTY 458
Cdd:pfam01833   79 PLTFTY 84
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 227-276 1.02e-09

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 55.41  E-value: 1.02e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720434751  227 AQRPSCGLCLKADpRFNCGWCISEHRCQLRAHCPAPKSNWMHPSQKGARC 276
Cdd:pfam01437    3 SQYTSCSSCLAAR-DPYCGWCSSEGRCVRRSACGAPEGNCEEWEQASSKC 51
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 76-123 3.79e-09

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 53.87  E-value: 3.79e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720434751   76 NCSALQSCMSCVGSPYP-CHWCKYRHVCTsHPHECSFQEGR----VHSPEGCP 123
Cdd:pfam01437    1 RCSQYTSCSSCLAARDPyCGWCSSEGRCV-RRSACGAPEGNceewEQASSKCP 52
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
227-268 7.16e-09

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 52.93  E-value: 7.16e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1720434751   227 AQRPSCGLCLKADPrFNCGWCISEHRCQLRAHCPAPKSNWMH 268
Cdd:smart00423    3 SKYTSCSECLLARD-PYCAWCSSQGRCTSGERCDSRRQNWLS 43
RasGAP cd04519
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ...
 1080-1235 7.49e-09

Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213328  Cd Length: 256  Bit Score: 58.27  E-value: 7.49e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1080 REGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRgsaLPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCL 1159
Cdd:cd04519    104 ESKESCEIDTKLPVGEDLEENLENLLELVNKLVDRILSSLDR---LPPELRYVFKILREFLAERFPEEPDEAYQAVSGFL 180

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1160 PLRFWVNVIKNPQFvFDIHKNSITD---ACLSVVAQTFMDSCSTSEhrlgkdsPSNKLLYAKD----IPNYKSWVERYYR 1232
Cdd:cd04519    181 FLRFICPAIVSPEL-FGLVPDEPSEqarRNLTLISKVLQSLANGVE-------FGDKEPFMKPlndfIKSNKPKLKQFLD 252


                   ...
gi 1720434751 1233 DIA 1235
Cdd:cd04519    253 ELS 255
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
76-123 1.98e-08

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 51.39  E-value: 1.98e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1720434751    76 NCSALQSCMSCVGSPYP-CHWCKYRHVCTsHPHECSFQEGRVhSPEGCP 123
Cdd:smart00423    1 RCSKYTSCSECLLARDPyCAWCSSQGRCT-SGERCDSRRQNW-LSGGCP 47
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 462-562 5.97e-08

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 51.31  E-value: 5.97e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  462 PTVTHLEPTWSIINGSTSITVSGTHLLTVQEPRVRakyrgIETTNTCQVI--NDTAMLCKAPGIFLGHPQPRAqgehpde 539
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVT-----FGGGVPCSVLsvSSTAIVCTTPPYANPGPGPVE------- 68

                           90       100
                   ....*....|....*....|...
gi 1720434751  540 fgFLLDHVQAARSLNRSSFTYYP 562
Cdd:cd00102     69 --VTVDRGNGGITSSPLTFTYVP 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 564-647 9.94e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 50.92  E-value: 9.94e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  564 PSFEPLGPS-GVLDvkPGSHVVLKGKNLipaaaGSSRLNYTVLIGGQPCALT-VSDTQLLCDSPSQT--GRQPVMVLVGG 639
Cdd:cd00603      1 PVITSISPSsGPLS--GGTRLTITGSNL-----GSGSPRVRVTVGGVPCKVLnVSSTEIVCRTPAAAtpGEGPVEVTVDG 73


                   ....*...
gi 1720434751  640 LEFWLGTL 647
Cdd:cd00603     74 ANVSARVL 81
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 565-639 1.14e-05

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 44.91  E-value: 1.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  565 SFEPL-GP-SGvldvkpGSHVVLKGKNLipaAAGSSRlnyTVLIGGQPCALT-VSDTQLLCDSPSQT--GRQPVMVLVGG 639
Cdd:cd01179      5 SLSPSyGPqSG------GTRLTITGKHL---NAGSSV---RVTVGGQPCKILsVSSSQIVCLTPPSAspGEAPVKVLIDG 72
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 580-650 2.29e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 43.97  E-value: 2.29e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720434751  580 GSHVVLKGKNLipaaaGSSRLNYTVLIGGQPCA-LTVSDTQLLCDSPSQT-GRQPVMVLVGGLEFWLGTLHIT 650
Cdd:pfam01833   16 GTTITITGSNF-----GTDSSDLKVTIGGTPCTvISVSSTTIVCTTPPGTsGLVNVSVTVGGGGISSSPLTFT 83
RasGAP_RASA3 cd05134
Ras-GTPase Activating Domain of RASA3; RASA3 (or GAP1_IP4BP) is a member of the GAP1 family ...
 1101-1236 4.81e-05

Ras-GTPase Activating Domain of RASA3; RASA3 (or GAP1_IP4BP) is a member of the GAP1 family and has been shown to specifically bind 1,3,4,5-tetrakisphosphate (IP4). Thus, RASA3 may function as an IP4 receptor. The members of GAP1 family are characterized by a conserved domain structure comprising N-terminal tandem C2 domains, a highly conserved central RasGAP domain, and a C-terminal pleckstrin-homology domain that is associated with a Bruton's tyrosine kinase motif. Purified RASA3 stimulates GAP activity on Ras with about a five-fold lower potency than p120RasGAP, but shows no GAP-stimulating activity at all against Rac or Rab3A.


Pssm-ID: 213336  Cd Length: 269  Bit Score: 46.56  E-value: 4.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751 1101 KGTLQKFVDDLFETVFSTahrGSALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQfVFDI--- 1177
Cdd:cd05134    131 RENLRQYVDRIFRVITKS---GVSCPTVMCDIFFSLRESAAKRFQVDPDVRYTAVSSFIFLRFFAPAILSPN-LFQLtph 206

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720434751 1178 HKNSITDACLSVVAQTFMDSCSTSEHRlgkdSPSNKLLYAKDIpnYKSWVERYYRDIAK 1236
Cdd:cd05134    207 HPDPQTSRTLTLISKTIQTLGSLSKSK----SANFKESYMAAF--YDYFNEQKYADAVK 259
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 374-446 5.45e-05

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 43.07  E-value: 5.45e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720434751  374 PTFDRVSPSRGPASGGTRLTISGISLD---AGSRVTVIIRDGECQFVR---RDAEAIVCISPVSTLGPSQSPITLAIDH 446
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGlrkNDVRHGVRVGGVPCNPEPpeySSSEKIVCTTGPAGNPVFNGPVEVTVGH 79
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 462-560 5.51e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 40.12  E-value: 5.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720434751  462 PTVTHLEPTWSIINGSTSITVSGTHLLTVQEpRVRAKYRGIETTNTcqVINDTAMLCKAPgiflghpqPRAQGEHPdefg 541
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSS-DLKVTIGGTPCTVI--SVSSTTIVCTTP--------PGTSGLVN---- 65

                           90
                   ....*....|....*....
gi 1720434751  542 FLLDHVQAARSLNRSSFTY 560
Cdd:pfam01833   66 VSVTVGGGGISSSPLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
563-633 7.45e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 39.71  E-value: 7.45e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720434751   563 DPSFEPLGPSGVLdVKPGSHVVLKGKNLIPAAAGSSRLNYtvliGGQPCALT-VSDTQLLCDSPSQT---GRQPV 633
Cdd:smart00429    1 DPVITRISPTSGP-VSGGTEITLCGKNLKSISVVFVEVGV----GEAPCTFSpSSSTAIVCKTPPYHnipGSVPV 70
RasGAP_GAP1_like cd05128
Ras-GTPase Activating Domain of GAP1 and similar proteins; The GAP1 family of Ras ...
 1101-1172 2.53e-03

Ras-GTPase Activating Domain of GAP1 and similar proteins; The GAP1 family of Ras GTPase-activating proteins includes GAP1(m) (or RASA2), GAP1_IP4BP (or RASA3), Ca2+ -promoted Ras inactivator (CAPRI, or RASAL4), and Ras GTPase activating-like proteins (RASAL) or RASAL1. The members are characterized by a conserved domain structure comprising N-terminal tandem C2 domains, a highly conserved central RasGAP domain, and a C-terminal pleckstrin homology domain that is associated with a Bruton's tyrosine kinase motif. While this domain structure is conserved, a small change in the function of each individual domain and the interaction between domains has a marked effect on the regulation of each protein.


Pssm-ID: 213330  Cd Length: 269  Bit Score: 41.47  E-value: 2.53e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720434751 1101 KGTLQKFVDDLFETVFSTAHRgsaLPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQ 1172
Cdd:cd05128    131 LANLRGYVERVFKAITSSARR---CPTLMCEIFSDLRESAAQRFPDNEDVPYTAVSGFIFLRFFAPAILNPK 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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