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Conserved domains on  [gi|1720405272|ref|XP_030108696|]
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fibronectin type III domain-containing protein 3B isoform X1 [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10047016)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; similar to fibronectin type-III domain-containing protein 3A/3B

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
540-799 4.33e-19

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 92.76  E-value: 4.33e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  540 NLKRSTQYKFRLTASNMEGKSCPSEVLVCTTSPDRPGPPTrPLIKGPVTSHGFSVKWDAPKDNGGSEilkYLLEItdGTS 619
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT-GLTATADTPGSVTLSWDPVTESDATG---YRVYR--SNS 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  620 EAGQWEVAYSGSATEYVFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSLAPGqcrPPRVL--GRPKHKGVHLEW 695
Cdd:COG3401    272 GDGPFTKVATVTTTSYTDTGLTNGTtyYYRVTA-VDAAGNESAPSNVVSVTTDLTPPA---APSGLtaTAVGSSSITLSW 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  696 DvPASESGceVSEYSVE-MTEPENVASEVYHGP-ELECTVGNLLPGTVYRFRVRALNDGG-YGPYSDVSEITTAAGPPGQ 772
Cdd:COG3401    348 T-ASSDAD--VTGYNVYrSTSGGGTYTKIAETVtTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGE 424

                          250       260
                   ....*....|....*....|....*..
gi 1720405272  773 cRAPRVSFTPDGCVLVGWESPASPGAD 799
Cdd:COG3401    425 -SLTASVDAVPLTDVAGATAAASAASN 450
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 481-570 1.21e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 1.21e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  481 PLAPRLVRAGV---TWITLQWSRPEGcSPEEVITYTLDIQE-DENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNM 556
Cdd:cd00063      1 PSPPTNLRVTDvtsTSVTLSWTPPED-DGGPITGYVVEYREkGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 1720405272  557 EGKSCPSEVLVCTT 570
Cdd:cd00063     80 GGESPPSESVTVTT 93
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
832-1066 1.26e-11

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.88  E-value: 1.26e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  832 PAAQYCCRLQAFNPAGAGPYSELVHCQTPASAPDPVSTLcvleeeppSAHPDSPSVcLVLNWEEpcNNGSEILAYNIDLG 911
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGL--------TATADTPGS-VTLSWDP--VTESDATGYRVYRS 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  912 DSC------ITVGNTTTHVMKNLLPETTYRIRIQAINEIGV-GPFSQFIKAKTRPLPPSP-PRLECAASGPQSLKLKWgD 983
Cdd:COG3401    270 NSGdgpftkVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAApSGLTATAVGSSSITLSW-T 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  984 SNSKTHAAGDMVYtlqledRNKRFISIYRG-----PSHTYKVQRLTEFTCYSFRIQAMSEAG-EGPYSETYTFSTTkSVP 1057
Cdd:COG3401    349 ASSDADVTGYNVY------RSTSGGGTYTKiaetvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTA-SAA 421


                   ....*....
gi 1720405272 1058 PTLKAPRVT 1066
Cdd:COG3401    422 SGESLTASV 430
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 382-473 1.42e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 1.42e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  382 PECPFPPKLAHRSKSSLTLQWKAPIDNGSKITSYLLEWDEgKRNSGFRQC--FFGSQKHCKLTKLCPAMGYTFRLAARND 459
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRE-KGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 1720405272  460 IGTSGYSQEVVCYT 473
Cdd:cd00063     80 GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 283-377 7.37e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 7.37e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  283 EKPQVSNIQARAVVLSWAPPVGLSCGPHGglsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAV 361
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDGGPITG-------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 1720405272  362 YNSVKGSCSEPVSFTT 377
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
1017-1149 4.74e-08

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.32  E-value: 4.74e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272 1017 TYKVQRLTEFTCYSFRIQAMSEAGEGPYSETYTFsTTKSVPPTlkAP---RVTQLEGNSCEIFWETVPPMRGDpvSYVLQ 1093
Cdd:COG3401    193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV-TTPTTPPS--APtglTATADTPGSVTLSWDPVTESDAT--GYRVY 267

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720405272 1094 VLVGRDSEYKQVYKGEEATFQISGLQSNTDYRFRVCAcrrcVDTSQELSgAFSPSA 1149
Cdd:COG3401    268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTA----VDAAGNES-APSNVV 318
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
540-799 4.33e-19

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 92.76  E-value: 4.33e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  540 NLKRSTQYKFRLTASNMEGKSCPSEVLVCTTSPDRPGPPTrPLIKGPVTSHGFSVKWDAPKDNGGSEilkYLLEItdGTS 619
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT-GLTATADTPGSVTLSWDPVTESDATG---YRVYR--SNS 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  620 EAGQWEVAYSGSATEYVFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSLAPGqcrPPRVL--GRPKHKGVHLEW 695
Cdd:COG3401    272 GDGPFTKVATVTTTSYTDTGLTNGTtyYYRVTA-VDAAGNESAPSNVVSVTTDLTPPA---APSGLtaTAVGSSSITLSW 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  696 DvPASESGceVSEYSVE-MTEPENVASEVYHGP-ELECTVGNLLPGTVYRFRVRALNDGG-YGPYSDVSEITTAAGPPGQ 772
Cdd:COG3401    348 T-ASSDAD--VTGYNVYrSTSGGGTYTKIAETVtTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGE 424

                          250       260
                   ....*....|....*....|....*..
gi 1720405272  773 cRAPRVSFTPDGCVLVGWESPASPGAD 799
Cdd:COG3401    425 -SLTASVDAVPLTDVAGATAAASAASN 450
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 691-765 5.50e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.98  E-value: 5.50e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720405272  691 VHLEWDVPASESGcEVSEYSVEMTEPENVASEVY---HGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITT 765
Cdd:cd00063     17 VTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVevtPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 481-570 1.21e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 1.21e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  481 PLAPRLVRAGV---TWITLQWSRPEGcSPEEVITYTLDIQE-DENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNM 556
Cdd:cd00063      1 PSPPTNLRVTDvtsTSVTLSWTPPED-DGGPITGYVVEYREkGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 1720405272  557 EGKSCPSEVLVCTT 570
Cdd:cd00063     80 GGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
832-1066 1.26e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.88  E-value: 1.26e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  832 PAAQYCCRLQAFNPAGAGPYSELVHCQTPASAPDPVSTLcvleeeppSAHPDSPSVcLVLNWEEpcNNGSEILAYNIDLG 911
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGL--------TATADTPGS-VTLSWDP--VTESDATGYRVYRS 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  912 DSC------ITVGNTTTHVMKNLLPETTYRIRIQAINEIGV-GPFSQFIKAKTRPLPPSP-PRLECAASGPQSLKLKWgD 983
Cdd:COG3401    270 NSGdgpftkVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAApSGLTATAVGSSSITLSW-T 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  984 SNSKTHAAGDMVYtlqledRNKRFISIYRG-----PSHTYKVQRLTEFTCYSFRIQAMSEAG-EGPYSETYTFSTTkSVP 1057
Cdd:COG3401    349 ASSDADVTGYNVY------RSTSGGGTYTKiaetvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTA-SAA 421


                   ....*....
gi 1720405272 1058 PTLKAPRVT 1066
Cdd:COG3401    422 SGESLTASV 430
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 382-473 1.42e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 1.42e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  382 PECPFPPKLAHRSKSSLTLQWKAPIDNGSKITSYLLEWDEgKRNSGFRQC--FFGSQKHCKLTKLCPAMGYTFRLAARND 459
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRE-KGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 1720405272  460 IGTSGYSQEVVCYT 473
Cdd:cd00063     80 GGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
385-466 8.11e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.35  E-value: 8.11e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  385 PFPPKLAHRSKSSLTLQWKAPIDNGSKITSYLLEWDEGKRNSGFRQCF-FGSQKHCKLTKLCPAMGYTFRLAARNDIGTS 463
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 1720405272  464 GYS 466
Cdd:pfam00041   83 PPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 575-659 1.47e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.78  E-value: 1.47e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272   575 PGPPTRPLIKgPVTSHGFSVKWDAPK-DNGGSEILKYllEITDGTSEAGQWEVAYSGSATEYVFTHLKPGTLYKLRACCI 653
Cdd:smart00060    1 PSPPSNLRVT-DVTSTSVTLSWEPPPdDGITGYIVGY--RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 1720405272   654 STGGHS 659
Cdd:smart00060   78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
878-950 3.72e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 3.72e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  878 PSAHPDSPSVcLVLNWEEPCNNGSEILAYNIDLGD--------SCITVGNTTTHVMKNLLPETTYRIRIQAINEIGVGPF 949
Cdd:pfam00041    6 LTVTDVTSTS-LTVSWTPPPDGNGPITGYEVEYRPknsgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84


                   .
gi 1720405272  950 S 950
Cdd:pfam00041   85 S 85
fn3 pfam00041
Fibronectin type III domain;
691-758 2.24e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.24e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720405272  691 VHLEWDVPASESGcEVSEYSVE---MTEPENVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYS 758
Cdd:pfam00041   16 LTVSWTPPPDGNG-PITGYEVEyrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 889-957 6.37e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 6.37e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720405272  889 LVLNWEEPCNNGSEILAYNI----DLGDSCITV----GNTTTHVMKNLLPETTYRIRIQAINEIGVGPFSQFIKAKT 957
Cdd:cd00063     17 VTLSWTPPEDDGGPITGYVVeyreKGSGDWKEVevtpGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 283-377 7.37e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 7.37e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  283 EKPQVSNIQARAVVLSWAPPVGLSCGPHGglsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAV 361
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDGGPITG-------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 1720405272  362 YNSVKGSCSEPVSFTT 377
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1017-1149 4.74e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.32  E-value: 4.74e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272 1017 TYKVQRLTEFTCYSFRIQAMSEAGEGPYSETYTFsTTKSVPPTlkAP---RVTQLEGNSCEIFWETVPPMRGDpvSYVLQ 1093
Cdd:COG3401    193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV-TTPTTPPS--APtglTATADTPGSVTLSWDPVTESDAT--GYRVY 267

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720405272 1094 VLVGRDSEYKQVYKGEEATFQISGLQSNTDYRFRVCAcrrcVDTSQELSgAFSPSA 1149
Cdd:COG3401    268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTA----VDAAGNES-APSNVV 318
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 382-463 5.54e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 5.54e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272   382 PECPFPPKLAHRSKSSLTLQWKAPIDNG--SKITSYLLEWDEgKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARND 459
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYRE-EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1720405272   460 IGTS 463
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 283-363 8.43e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 8.43e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272   283 EKPQVSNIQARAVVLSWAPPVglscgPHGGLSFPYSYEVALSDKGRDGKyKIIYSGEELECNLKDLRPATDYHVRVYAVY 362
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPP-----DDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    .
gi 1720405272   363 N 363
Cdd:smart00060   79 G 79
fn3 pfam00041
Fibronectin type III domain;
285-367 4.83e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.57  E-value: 4.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  285 PQVSNIQARAVVLSWAPPVGLScGPhgglsfPYSYEVALS--DKGRDGKYKIIySGEELECNLKDLRPATDYHVRVYAVY 362
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGN-GP------ITGYEVEYRpkNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*
gi 1720405272  363 NSVKG 367
Cdd:pfam00041   78 GGGEG 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 864-947 5.19e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 5.19e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272   864 PDPVSTLCVLEEEPPSahpdspsvcLVLNWEEP--CNNGSEILAYNIDLGDS------CITVGNTTTHVMKNLLPETTYR 935
Cdd:smart00060    1 PSPPSNLRVTDVTSTS---------VTLSWEPPpdDGITGYIVGYRVEYREEgsewkeVNVTPSSTSYTLTGLKPGTEYE 71

                            90
                    ....*....|..
gi 1720405272   936 IRIQAINEIGVG 947
Cdd:smart00060   72 FRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1057-1130 8.78e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.26  E-value: 8.78e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720405272 1057 PPTLKAPRVTQLEGNSCEIFWETVPPMRGDPVSYVLQVLVGRDSEYKQVYK--GEEATFQISGLQSNTDYRFRVCA 1130
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 478-560 1.04e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 1.04e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272   478 PQMPLAPRLVRAGVTWITLQWSRPEGCSPEE-VITYTLDIQEDENDSHFHPKyTGEDLTCTVKNLKRSTQYKFRLTASNM 556
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1720405272   557 EGKS 560
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1057-1130 1.27e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 1.27e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720405272  1057 PPTLKAPRVTQLEGNSCEIFWEtvPPMRGDPVSYVLQVLV---GRDSEYKQVYKGEEAT-FQISGLQSNTDYRFRVCA 1130
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWE--PPPDDGITGYIVGYRVeyrEEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
1057-1130 1.75e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.75e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720405272 1057 PPTlkAPRVTQLEGNSCEIFWETVPPMRGDPVSYVLQVLVGRDSEYKQVY--KGEEATFQISGLQSNTDYRFRVCA 1130
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQA 75
fn3 pfam00041
Fibronectin type III domain;
483-563 2.04e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 2.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  483 APRLVRA---GVTWITLQWSRPEGCSpEEVITYTLDIQE-DENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNMEG 558
Cdd:pfam00041    2 APSNLTVtdvTSTSLTVSWTPPPDGN-GPITGYEVEYRPkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 1720405272  559 KSCPS 563
Cdd:pfam00041   81 EGPPS 85
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
540-799 4.33e-19

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 92.76  E-value: 4.33e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  540 NLKRSTQYKFRLTASNMEGKSCPSEVLVCTTSPDRPGPPTrPLIKGPVTSHGFSVKWDAPKDNGGSEilkYLLEItdGTS 619
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT-GLTATADTPGSVTLSWDPVTESDATG---YRVYR--SNS 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  620 EAGQWEVAYSGSATEYVFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSLAPGqcrPPRVL--GRPKHKGVHLEW 695
Cdd:COG3401    272 GDGPFTKVATVTTTSYTDTGLTNGTtyYYRVTA-VDAAGNESAPSNVVSVTTDLTPPA---APSGLtaTAVGSSSITLSW 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  696 DvPASESGceVSEYSVE-MTEPENVASEVYHGP-ELECTVGNLLPGTVYRFRVRALNDGG-YGPYSDVSEITTAAGPPGQ 772
Cdd:COG3401    348 T-ASSDAD--VTGYNVYrSTSGGGTYTKIAETVtTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGE 424

                          250       260
                   ....*....|....*....|....*..
gi 1720405272  773 cRAPRVSFTPDGCVLVGWESPASPGAD 799
Cdd:COG3401    425 -SLTASVDAVPLTDVAGATAAASAASN 450
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
569-945 2.86e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 86.98  E-value: 2.86e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  569 TTSPDRPGPPTRPLIKGPVTSHGFSVKWDAPKDNGGSEILKYLLEITDGTSEAGQWEVAYSGSATEYVFTHLKPGTLYKL 648
Cdd:COG3401    128 ATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYY 207

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  649 RACCISTGGHSQCSESLPVRTLSLAPGQcrPPRVLGRPK-HKGVHLEWDvPASESGceVSEYSVEMTEPENVA-SEVYHG 726
Cdd:COG3401    208 RVAATDTGGESAPSNEVSVTTPTTPPSA--PTGLTATADtPGSVTLSWD-PVTESD--ATGYRVYRSNSGDGPfTKVATV 282

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  727 PELECTVGNLLPGTVYRFRVRALN-DGGYGPYSDVSEITTAAGPPGQCRAPRVSFTPDGCVLVGWEspASPGADISEYRL 805
Cdd:COG3401    283 TTTSYTDTGLTNGTTYYYRVTAVDaAGNESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWT--ASSDADVTGYNV 360

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  806 E-WGEDEQSLELVYHGPD-TCFEMRDLLPAAQYCCRLQAFNPAG-AGPYSELVHCQTPASAPDPVSTLCVLEEEPPSAHP 882
Cdd:COG3401    361 YrSTSGGGTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLTASVDAVPLTDVAG 440

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720405272  883 DSPSVclvlnWEEPCNNGSEILAYNIDLGDSCITVGNTTTHVMKNLLPETTYRIRIQAINEIG 945
Cdd:COG3401    441 ATAAA-----SAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVG 498
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
450-782 2.94e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 77.35  E-value: 2.94e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  450 YTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPLAPRLVRAGVTWITLQWSRPEGcspEEVITYTLDIQEDENDShFHPKY 529
Cdd:COG3401    205 YYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTE---SDATGYRVYRSNSGDGP-FTKVA 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  530 TGEDLTCTVKNLKRSTQYKFRLTASNMEG-KSCPSEVLVCTTSPDRPGPPTrPLIKGPVTSHGFSVKWDAPKDNGgseIL 608
Cdd:COG3401    281 TVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPS-GLTATAVGSSSITLSWTASSDAD---VT 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  609 KYLLEItdGTSEAGQWE-VAYSGSATEYVFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSLAPGQcRPPRVLGR 685
Cdd:COG3401    357 GYNVYR--STSGGGTYTkIAETVTTTSYTDTGLTPGTtyYYKVTA-VDAAGNESAPSEEVSATTASAASGE-SLTASVDA 432

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  686 PKHKGVHLEWDVPASESGCEVSEYSVEMTEPENVASEVYHGPELECTVGNLLPGTVYRFrVRALNDGGYGPYSDVSEITT 765
Cdd:COG3401    433 VPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSV-TTGSLVGGSGASSVTNSVSV 511

                          330
                   ....*....|....*..
gi 1720405272  766 AAGPPGQCRAPRVSFTP 782
Cdd:COG3401    512 IGASAAAAVGGAPDGTP 528
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 691-765 5.50e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.98  E-value: 5.50e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720405272  691 VHLEWDVPASESGcEVSEYSVEMTEPENVASEVY---HGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITT 765
Cdd:cd00063     17 VTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVevtPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 575-669 1.44e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 1.44e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  575 PGPPTRPLIKgPVTSHGFSVKWDAPKDNGGsEILKYLLEITDGTSEAGQWEVAYSGSATEYVFTHLKPGTLYKLRACCIS 654
Cdd:cd00063      1 PSPPTNLRVT-DVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|....*
gi 1720405272  655 TGGHSQCSESLPVRT 669
Cdd:cd00063     79 GGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 481-570 1.21e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 1.21e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  481 PLAPRLVRAGV---TWITLQWSRPEGcSPEEVITYTLDIQE-DENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNM 556
Cdd:cd00063      1 PSPPTNLRVTDvtsTSVTLSWTPPED-DGGPITGYVVEYREkGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 1720405272  557 EGKSCPSEVLVCTT 570
Cdd:cd00063     80 GGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
832-1066 1.26e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.88  E-value: 1.26e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  832 PAAQYCCRLQAFNPAGAGPYSELVHCQTPASAPDPVSTLcvleeeppSAHPDSPSVcLVLNWEEpcNNGSEILAYNIDLG 911
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGL--------TATADTPGS-VTLSWDP--VTESDATGYRVYRS 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  912 DSC------ITVGNTTTHVMKNLLPETTYRIRIQAINEIGV-GPFSQFIKAKTRPLPPSP-PRLECAASGPQSLKLKWgD 983
Cdd:COG3401    270 NSGdgpftkVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAApSGLTATAVGSSSITLSW-T 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  984 SNSKTHAAGDMVYtlqledRNKRFISIYRG-----PSHTYKVQRLTEFTCYSFRIQAMSEAG-EGPYSETYTFSTTkSVP 1057
Cdd:COG3401    349 ASSDADVTGYNVY------RSTSGGGTYTKiaetvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTA-SAA 421


                   ....*....
gi 1720405272 1058 PTLKAPRVT 1066
Cdd:COG3401    422 SGESLTASV 430
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 382-473 1.42e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 1.42e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  382 PECPFPPKLAHRSKSSLTLQWKAPIDNGSKITSYLLEWDEgKRNSGFRQC--FFGSQKHCKLTKLCPAMGYTFRLAARND 459
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRE-KGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 1720405272  460 IGTSGYSQEVVCYT 473
Cdd:cd00063     80 GGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
930-1150 1.47e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.49  E-value: 1.47e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  930 PETTYRIRIQAINEIGVGPFSQFIKAKTRPLPPSPPRL-ECAASGPQSLKLKWgDSNSKTHAAGDMVYtlQLEDRNKRFI 1008
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGlTATADTPGSVTLSW-DPVTESDATGYRVY--RSNSGDGPFT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272 1009 SIYRGPSHTYKVQRLTEFTCYSFRIQAMSEAG-EGPYSETYTFSTTKSVPPTLKAPRVTQLEGNSCEIFWETVPPmrGDP 1087
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSD--ADV 355

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720405272 1088 VSYVLQVLVGRDSEYKQVYKGEEAT-FQISGLQSNTDYRFRVcacrRCVDTSQELSGAFSPSAA 1150
Cdd:COG3401    356 TGYNVYRSTSGGGTYTKIAETVTTTsYTDTGLTPGTTYYYKV----TAVDAAGNESAPSEEVSA 415
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 770-859 4.41e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.59  E-value: 4.41e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  770 PGQCRAPRVSFTPDGCVLVGWESPASPGADISEYRLEW---GEDEQSLELVYHGPDTCFEMRDLLPAAQYCCRLQAFNPA 846
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrekGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1720405272  847 GAGPYSELVHCQT 859
Cdd:cd00063     81 GESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
350-638 5.21e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 66.95  E-value: 5.21e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  350 PATDYHVRVYAVYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGskITSYLLEWDEGKrNSGFR 429
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSG-DGPFT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  430 QCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGT-SGYSQEVVCYTLGNIPQMPLAPRLVRAGVTWITLQWSRPegcSPEE 508
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS---SDAD 354

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  509 VITYTLDiQEDENDSHFHP-KYTGEDLTCTVKNLKRSTQYKFRLTASNMEG-KSCPSEVLVCTTSPDRPGPPT---RPLI 583
Cdd:COG3401    355 VTGYNVY-RSTSGGGTYTKiAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLtasVDAV 433

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720405272  584 KGPVTSHGFSVKWDAPKDNGGSEIL--------KYLLEITDGTSEAGQWEVAYSGSATEYVFT 638
Cdd:COG3401    434 PLTDVAGATAAASAASNPGVSAAVLadggdtgnAVPFTTTSSTVTATTTDTTTANLSVTTGSL 496
fn3 pfam00041
Fibronectin type III domain;
385-466 8.11e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.35  E-value: 8.11e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  385 PFPPKLAHRSKSSLTLQWKAPIDNGSKITSYLLEWDEGKRNSGFRQCF-FGSQKHCKLTKLCPAMGYTFRLAARNDIGTS 463
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 1720405272  464 GYS 466
Cdd:pfam00041   83 PPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 575-659 1.47e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.78  E-value: 1.47e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272   575 PGPPTRPLIKgPVTSHGFSVKWDAPK-DNGGSEILKYllEITDGTSEAGQWEVAYSGSATEYVFTHLKPGTLYKLRACCI 653
Cdd:smart00060    1 PSPPSNLRVT-DVTSTSVTLSWEPPPdDGITGYIVGY--RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 1720405272   654 STGGHS 659
Cdd:smart00060   78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
878-950 3.72e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 3.72e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  878 PSAHPDSPSVcLVLNWEEPCNNGSEILAYNIDLGD--------SCITVGNTTTHVMKNLLPETTYRIRIQAINEIGVGPF 949
Cdd:pfam00041    6 LTVTDVTSTS-LTVSWTPPPDGNGPITGYEVEYRPknsgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84


                   .
gi 1720405272  950 S 950
Cdd:pfam00041   85 S 85
fn3 pfam00041
Fibronectin type III domain;
691-758 2.24e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.24e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720405272  691 VHLEWDVPASESGcEVSEYSVE---MTEPENVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYS 758
Cdd:pfam00041   16 LTVSWTPPPDGNG-PITGYEVEyrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 674-755 4.28e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 4.28e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272   674 PGQCRPPRVLGRPKHKgVHLEWDVPASE-SGCEVSEYSVEMTEPENVASEVYHGP-ELECTVGNLLPGTVYRFRVRALND 751
Cdd:smart00060    1 PSPPSNLRVTDVTSTS-VTLSWEPPPDDgITGYIVGYRVEYREEGSEWKEVNVTPsSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1720405272   752 GGYG 755
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 889-957 6.37e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 6.37e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720405272  889 LVLNWEEPCNNGSEILAYNI----DLGDSCITV----GNTTTHVMKNLLPETTYRIRIQAINEIGVGPFSQFIKAKT 957
Cdd:cd00063     17 VTLSWTPPEDDGGPITGYVVeyreKGSGDWKEVevtpGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 283-377 7.37e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 7.37e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  283 EKPQVSNIQARAVVLSWAPPVGLSCGPHGglsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAV 361
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDGGPITG-------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 1720405272  362 YNSVKGSCSEPVSFTT 377
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
576-660 1.02e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.57  E-value: 1.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  576 GPPTRPLIKgPVTSHGFSVKWDAPKDnGGSEILKYLLEITDGTSEAGQWEVAYSGSATEYVFTHLKPGTLYKLRACCIST 655
Cdd:pfam00041    1 SAPSNLTVT-DVTSTSLTVSWTPPPD-GNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*
gi 1720405272  656 GGHSQ 660
Cdd:pfam00041   79 GGEGP 83
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
593-795 2.28e-08

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 58.80  E-value: 2.28e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  593 SVKWDAPKDNGGseilkYLLEITDGtseAGQWEVAYSGSATEYVFTHLKPGTlYKLRACCISTGGHSQCSESLPVRTLS- 671
Cdd:COG4733    555 TVSWDAPAGAVA-----YEVEWRRD---DGNWVSVPRTSGTSFEVPGIYAGD-YEVRVRAINALGVSSAWAASSETTVTg 625

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  672 -LAPgqcrPPRVLG---RPKHKGVHLEWDVPAsesGCEVSEYSVEM---TEPENVASEVYHGPELECTVGNLLPGTVYRF 744
Cdd:COG4733    626 kTAP----PPAPTGltaTGGLGGITLSWSFPV---DADTLRTEIRYsttGDWASATVAQALYPGNTYTLAGLKAGQTYYY 698

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1720405272  745 RVRALNDGG-YGPYSDVSEITTAAGPPGQCRAPRVSFTPDGCVLVGWESPAS 795
Cdd:COG4733    699 RARAVDRSGnVSAWWVSGQASADAAGILDAITGQILETELGQELDAIIQNAT 750
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1017-1149 4.74e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.32  E-value: 4.74e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272 1017 TYKVQRLTEFTCYSFRIQAMSEAGEGPYSETYTFsTTKSVPPTlkAP---RVTQLEGNSCEIFWETVPPMRGDpvSYVLQ 1093
Cdd:COG3401    193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV-TTPTTPPS--APtglTATADTPGSVTLSWDPVTESDAT--GYRVY 267

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720405272 1094 VLVGRDSEYKQVYKGEEATFQISGLQSNTDYRFRVCAcrrcVDTSQELSgAFSPSA 1149
Cdd:COG3401    268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTA----VDAAGNES-APSNVV 318
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 382-463 5.54e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 5.54e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272   382 PECPFPPKLAHRSKSSLTLQWKAPIDNG--SKITSYLLEWDEgKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARND 459
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYRE-EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1720405272   460 IGTS 463
Cdd:smart00060   80 AGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
286-638 7.27e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.55  E-value: 7.27e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  286 QVSNIQARAVVLSWAPPvglscgPHGGLSfpySYEVALSDKGrDGKYKIIYSGEELECNLKDLRPATDYHVRVYAV-YNS 364
Cdd:COG3401    240 TATADTPGSVTLSWDPV------TESDAT---GYRVYRSNSG-DGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdAAG 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  365 VKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGskITSYLLEWDEGKrNSGFRQ-CFFGSQKHCKLTK 443
Cdd:COG3401    310 NESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDAD--VTGYNVYRSTSG-GGTYTKiAETVTTTSYTDTG 386

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  444 LCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPLAPRLVRAGVTWITLQWSRP--EGCSPEEVITYTLDIQEDEN 521
Cdd:COG3401    387 LTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAasAASNPGVSAAVLADGGDTGN 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  522 DSHFHPkyTGEDLTCTVKNLKRSTQYKFRLTASNMEGKScpsevlVCTTSPDRPGPPTRPLIKGPVTSHGFSVKWDAPKD 601
Cdd:COG3401    467 AVPFTT--TSSTVTATTTDTTTANLSVTTGSLVGGSGAS------SVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTV 538

                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 1720405272  602 NGGSEILKYLLEITDGTSEAGQWEVAYSGSATEYVFT 638
Cdd:COG3401    539 GASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYLIT 575
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 283-363 8.43e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 8.43e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272   283 EKPQVSNIQARAVVLSWAPPVglscgPHGGLSFPYSYEVALSDKGRDGKyKIIYSGEELECNLKDLRPATDYHVRVYAVY 362
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPP-----DDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    .
gi 1720405272   363 N 363
Cdd:smart00060   79 G 79
fn3 pfam00041
Fibronectin type III domain;
285-367 4.83e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.57  E-value: 4.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  285 PQVSNIQARAVVLSWAPPVGLScGPhgglsfPYSYEVALS--DKGRDGKYKIIySGEELECNLKDLRPATDYHVRVYAVY 362
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGN-GP------ITGYEVEYRpkNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*
gi 1720405272  363 NSVKG 367
Cdd:pfam00041   78 GGGEG 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 864-947 5.19e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 5.19e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272   864 PDPVSTLCVLEEEPPSahpdspsvcLVLNWEEP--CNNGSEILAYNIDLGDS------CITVGNTTTHVMKNLLPETTYR 935
Cdd:smart00060    1 PSPPSNLRVTDVTSTS---------VTLSWEPPpdDGITGYIVGYRVEYREEgsewkeVNVTPSSTSYTLTGLKPGTEYE 71

                            90
                    ....*....|..
gi 1720405272   936 IRIQAINEIGVG 947
Cdd:smart00060   72 FRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1057-1130 8.78e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.26  E-value: 8.78e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720405272 1057 PPTLKAPRVTQLEGNSCEIFWETVPPMRGDPVSYVLQVLVGRDSEYKQVYK--GEEATFQISGLQSNTDYRFRVCA 1130
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 478-560 1.04e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 1.04e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272   478 PQMPLAPRLVRAGVTWITLQWSRPEGCSPEE-VITYTLDIQEDENDSHFHPKyTGEDLTCTVKNLKRSTQYKFRLTASNM 556
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1720405272   557 EGKS 560
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 770-849 1.96e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 1.96e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272   770 PGQCRAPRVSFTPDGCVLVGWESPASPGAD--ISEYRLEWGE-DEQSLELVYHGPDTCFEMRDLLPAAQYCCRLQAFNPA 846
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 1720405272   847 GAG 849
Cdd:smart00060   81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 973-1052 7.82e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.57  E-value: 7.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  973 GPQSLKLKWgdSNSKTHAAGDMVYTLQLEDRNK---RFISIYRGPSHTYKVQRLTEFTCYSFRIQAMSEAGEGPYSETYT 1049
Cdd:cd00063     13 TSTSVTLSW--TPPEDDGGPITGYVVEYREKGSgdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVT 90


                   ...
gi 1720405272 1050 FST 1052
Cdd:cd00063     91 VTT 93
fn3 pfam00041
Fibronectin type III domain;
786-852 1.14e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.71  E-value: 1.14e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  786 VLVGWESPASPGADISEYRLEW---GEDEQSLELVYHGPDTCFEMRDLLPAAQYCCRLQAFNPAGAGPYS 852
Cdd:pfam00041   16 LTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1057-1130 1.27e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 1.27e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720405272  1057 PPTLKAPRVTQLEGNSCEIFWEtvPPMRGDPVSYVLQVLV---GRDSEYKQVYKGEEAT-FQISGLQSNTDYRFRVCA 1130
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWE--PPPDDGITGYIVGYRVeyrEEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
1057-1130 1.75e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.75e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720405272 1057 PPTlkAPRVTQLEGNSCEIFWETVPPMRGDPVSYVLQVLVGRDSEYKQVY--KGEEATFQISGLQSNTDYRFRVCA 1130
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQA 75
fn3 pfam00041
Fibronectin type III domain;
483-563 2.04e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 2.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405272  483 APRLVRA---GVTWITLQWSRPEGCSpEEVITYTLDIQE-DENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNMEG 558
Cdd:pfam00041    2 APSNLTVtdvTSTSLTVSWTPPPDGN-GPITGYEVEYRPkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 1720405272  559 KSCPS 563
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 971-1042 1.80e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 38.36  E-value: 1.80e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720405272   971 ASGPQSLKLKWGDSNSKTHAAGDMVYTLQLEDRNKRFISIYRGPSHT-YKVQRLTEFTCYSFRIQAMSEAGEG 1042
Cdd:smart00060   11 DVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGAGEG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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