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Conserved domains on  [gi|1720414130|ref|XP_030110513|]
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volume-regulated anion channel subunit LRRC8B isoform X1 [Mus musculus]

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 12117038)

Pannexin_like and LRR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-334 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 530.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130   1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLC-----CLPCKVEFDNQCAVPWDLLKG 75
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVClpcleSPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130  76 SENASSNSGLLLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVSI 155
Cdd:pfam12534  81 APTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 156 LHKCFDSPWTTRALSETVAEQSVRPLKLSKSKTLL-----STSGGSADIDASKQSLPYPQPGLESPGIE-SPTSSVLDKK 229
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 230 EGEQAKAIFEKVKRFRLHVEQRDIIYRVYLKQIIVKVILFVLIITYVPYFLSYITLEIDCSIDVQAFTGYKRYQCVYSLA 309
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 1720414130 310 EIFKVLASFYVILVMLYGLTSSYSL 334
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
471-802 3.14e-34

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.83  E-value: 3.14e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 471 YHSSLVVDHPALAFLEENLRILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSSLHLEGFQDLKNLRTLYLKSSLS 550
Cdd:COG4886     6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 551 RIPQVVTDLLPSLQKLSLDNegsklvvLNNLKKMVNLKSLELLSCDLERIPHSIFSLNNLHELDLKENNLKTVEEiiSFQ 630
Cdd:COG4886    86 LLGLTDLGDLTNLTELDLSG-------NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 631 HLPSLSCLKLWHNNIAYIPAQIGALSNLEQLFLGHNNIESLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVT 710
Cdd:COG4886   157 NLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 711 NNNIEMLPDgLFQCKKLQCLLLGRNSLTDLSPLvGELSNLTHLELTGNYLETLPVELEGCQSLKRSCLIVEDSLLNSLPL 790
Cdd:COG4886   237 NNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                         330
                  ....*....|..
gi 1720414130 791 PVAERLQTCLDK 802
Cdd:COG4886   315 ILLLLLTTLLLL 326
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-334 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 530.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130   1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLC-----CLPCKVEFDNQCAVPWDLLKG 75
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVClpcleSPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130  76 SENASSNSGLLLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVSI 155
Cdd:pfam12534  81 APTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 156 LHKCFDSPWTTRALSETVAEQSVRPLKLSKSKTLL-----STSGGSADIDASKQSLPYPQPGLESPGIE-SPTSSVLDKK 229
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 230 EGEQAKAIFEKVKRFRLHVEQRDIIYRVYLKQIIVKVILFVLIITYVPYFLSYITLEIDCSIDVQAFTGYKRYQCVYSLA 309
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 1720414130 310 EIFKVLASFYVILVMLYGLTSSYSL 334
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
471-802 3.14e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.83  E-value: 3.14e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 471 YHSSLVVDHPALAFLEENLRILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSSLHLEGFQDLKNLRTLYLKSSLS 550
Cdd:COG4886     6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 551 RIPQVVTDLLPSLQKLSLDNegsklvvLNNLKKMVNLKSLELLSCDLERIPHSIFSLNNLHELDLKENNLKTVEEiiSFQ 630
Cdd:COG4886    86 LLGLTDLGDLTNLTELDLSG-------NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 631 HLPSLSCLKLWHNNIAYIPAQIGALSNLEQLFLGHNNIESLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVT 710
Cdd:COG4886   157 NLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 711 NNNIEMLPDgLFQCKKLQCLLLGRNSLTDLSPLvGELSNLTHLELTGNYLETLPVELEGCQSLKRSCLIVEDSLLNSLPL 790
Cdd:COG4886   237 NNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                         330
                  ....*....|..
gi 1720414130 791 PVAERLQTCLDK 802
Cdd:COG4886   315 ILLLLLTTLLLL 326
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 512-767 9.82e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 81.82  E-value: 9.82e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 512 LKELYLSGCVLPEQLSSLhlegFQDLKNLRTLYLKSS-LS-RIPQVVTDLLPSLQKLSLDNegsklvvlNNLKKMVNLKS 589
Cdd:PLN00113   71 VVSIDLSGKNISGKISSA----IFRLPYIQTINLSNNqLSgPIPDDIFTTSSSLRYLNLSN--------NNFTGSIPRGS 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 590 LELL-SCDLE------RIPHSIFSLNNLHELDLKENNLktVEEI-ISFQHLPSLSCLKLWHNN-IAYIPAQIGALSNLEQ 660
Cdd:PLN00113  139 IPNLeTLDLSnnmlsgEIPNDIGSFSSLKVLDLGGNVL--VGKIpNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKW 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 661 LFLGHNNIE-SLPLQLFLCTKLHYLDLSYNHLTF-IPEEIQYLTNLQYFAVTNNNIE-MLPDGLFQCKKLQCLLLGRNSL 737
Cdd:PLN00113  217 IYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTGpIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSL 296

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1720414130 738 TDLSP-LVGELSNLTHLELTGNYLE-TLPVEL 767
Cdd:PLN00113  297 SGEIPeLVIQLQNLEILHLFSNNFTgKIPVAL 328
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 609-758 2.15e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.12  E-value: 2.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 609 NLHELDLKENNLKTVEeiiSFQHLPSLSCLKLWHNNIAYIPaQIGALSNLEQLFLGHNNIESLPlQLFLCTKLHYLDLSY 688
Cdd:cd21340    25 NLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVVE-GLENLTNLEELHIEN 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 689 NHL------TFIPEEIQYLTN-LQYFAVTNNNIEMLpDGLFQCKKLQCLLLGRN---SLTDLSPLVGELSNLTHLELTGN 758
Cdd:cd21340   100 QRLppgeklTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNqisDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
702-760 2.28e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.28e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720414130 702 TNLQYFAVTNNNIEMLPDGLFQ-CKKLQCLLLGRNSLTDLSP--LVGeLSNLTHLELTGNYL 760
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPgaFSG-LPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-334 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 530.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130   1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLC-----CLPCKVEFDNQCAVPWDLLKG 75
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVClpcleSPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130  76 SENASSNSGLLLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVSI 155
Cdd:pfam12534  81 APTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 156 LHKCFDSPWTTRALSETVAEQSVRPLKLSKSKTLL-----STSGGSADIDASKQSLPYPQPGLESPGIE-SPTSSVLDKK 229
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 230 EGEQAKAIFEKVKRFRLHVEQRDIIYRVYLKQIIVKVILFVLIITYVPYFLSYITLEIDCSIDVQAFTGYKRYQCVYSLA 309
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 1720414130 310 EIFKVLASFYVILVMLYGLTSSYSL 334
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
471-802 3.14e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.83  E-value: 3.14e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 471 YHSSLVVDHPALAFLEENLRILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSSLHLEGFQDLKNLRTLYLKSSLS 550
Cdd:COG4886     6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 551 RIPQVVTDLLPSLQKLSLDNegsklvvLNNLKKMVNLKSLELLSCDLERIPHSIFSLNNLHELDLKENNLKTVEEiiSFQ 630
Cdd:COG4886    86 LLGLTDLGDLTNLTELDLSG-------NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 631 HLPSLSCLKLWHNNIAYIPAQIGALSNLEQLFLGHNNIESLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVT 710
Cdd:COG4886   157 NLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 711 NNNIEMLPDgLFQCKKLQCLLLGRNSLTDLSPLvGELSNLTHLELTGNYLETLPVELEGCQSLKRSCLIVEDSLLNSLPL 790
Cdd:COG4886   237 NNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                         330
                  ....*....|..
gi 1720414130 791 PVAERLQTCLDK 802
Cdd:COG4886   315 ILLLLLTTLLLL 326
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
539-789 1.08e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.49  E-value: 1.08e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 539 NLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELLSCDLERIPHSIFSLNNLHELDLKEN 618
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 619 NLKTVEEIISFQHLPSLSCLKLWHNNiayipaQIGALSNLEQLFLGHNNIESLPLQLFLCTKLHYLDLSYNHLTFIPEEI 698
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 699 QYLTNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGRNSLTDLSPLVGELSNLTHLELTGNYLETLPVELEGCQSLKRscL 778
Cdd:COG4886   156 GNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLET--L 233

                         250
                  ....*....|.
gi 1720414130 779 IVEDSLLNSLP 789
Cdd:COG4886   234 DLSNNQLTDLP 244
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
368-797 1.48e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.08  E-value: 1.48e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 368 FILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVERLKSKLVKNSQDKVELHLFMLNGLPDNVFELTEMEVLSL 447
Cdd:COG4886     3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 448 ELipEVKLPAAVAQLVNLRELHVYHSslvvdhPALAFLEeNLRILRLKFTEMGKIPRWVFHLKNLKELYLSGCvlpeQLS 527
Cdd:COG4886    83 SL--LLLGLTDLGDLTNLTELDLSGN------EELSNLT-NLESLDLSGNQLTDLPEELANLTNLKELDLSNN----QLT 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 528 SLHlEGFQDLKNLRTLYLKS-SLSRIPQVVTDLlPSLQKLSLDNegSKLVVL-NNLKKMVNLKSLELLSCDLERIPHSIF 605
Cdd:COG4886   150 DLP-EPLGNLTNLKSLDLSNnQLTDLPEELGNL-TNLKELDLSN--NQITDLpEPLGNLTNLEELDLSGNQLTDLPEPLA 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 606 SLNNLHELDLKENNLKTVEEIisfQHLPSLSCLKLWHNNIAYIPAqIGALSNLEQLFLGHNNIESLPLQ-LFLCTKLHYL 684
Cdd:COG4886   226 NLTNLETLDLSNNQLTDLPEL---GNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLKeLELLLGLNSL 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 685 DLSYNHLTFIPEEIQYLTNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGRNSLTDLSPLVGELSNLTHLELTGNYLETLP 764
Cdd:COG4886   302 LLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1720414130 765 VELEGCQSLKRSCLIVEDSLLNSLPLPVAERLQ 797
Cdd:COG4886   382 LALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
338-743 4.88e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.46  E-value: 4.88e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 338 LRSSLKQYSFEALREKSNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVERLKSKLVKN 417
Cdd:COG4886    12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 418 SQDKVELHLFMLNGlPDNVFELTEMEVLSLELIPEVKLPAAVAQLVNLRELHVYHSSLVVDHPALAFLEeNLRILRLKFT 497
Cdd:COG4886    92 LGDLTNLTELDLSG-NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLT-NLKSLDLSNN 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 498 EMGKIPRWVFHLKNLKELYLSGCvlpeQLSSLHLEgFQDLKNLRTLYL-KSSLSRIPQVVTDlLPSLQKLSLDNegSKLV 576
Cdd:COG4886   170 QLTDLPEELGNLTNLKELDLSNN----QITDLPEP-LGNLTNLEELDLsGNQLTDLPEPLAN-LTNLETLDLSN--NQLT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 577 VLNNLKKMVNLKSLELLSCDLERIPHSiFSLNNLHELDLKENNLKT--VEEIISFQHLPSLSCLKLWHNNIAYIPAQIGA 654
Cdd:COG4886   242 DLPELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDlkLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 655 LSNLEQLFLGHNN---IESLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVTNNNIEMLPDGLFQCKKLQCLL 731
Cdd:COG4886   321 TTLLLLLLLLKGLlvtLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGV 400

                         410
                  ....*....|..
gi 1720414130 732 LGRNSLTDLSPL 743
Cdd:COG4886   401 LLLTLALLDAVN 412
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 512-767 9.82e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 81.82  E-value: 9.82e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 512 LKELYLSGCVLPEQLSSLhlegFQDLKNLRTLYLKSS-LS-RIPQVVTDLLPSLQKLSLDNegsklvvlNNLKKMVNLKS 589
Cdd:PLN00113   71 VVSIDLSGKNISGKISSA----IFRLPYIQTINLSNNqLSgPIPDDIFTTSSSLRYLNLSN--------NNFTGSIPRGS 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 590 LELL-SCDLE------RIPHSIFSLNNLHELDLKENNLktVEEI-ISFQHLPSLSCLKLWHNN-IAYIPAQIGALSNLEQ 660
Cdd:PLN00113  139 IPNLeTLDLSnnmlsgEIPNDIGSFSSLKVLDLGGNVL--VGKIpNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKW 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 661 LFLGHNNIE-SLPLQLFLCTKLHYLDLSYNHLTF-IPEEIQYLTNLQYFAVTNNNIE-MLPDGLFQCKKLQCLLLGRNSL 737
Cdd:PLN00113  217 IYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTGpIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSL 296

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1720414130 738 TDLSP-LVGELSNLTHLELTGNYLE-TLPVEL 767
Cdd:PLN00113  297 SGEIPeLVIQLQNLEILHLFSNNFTgKIPVAL 328
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
485-795 7.40e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 72.42  E-value: 7.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 485 LEENLRILRLKFTEMGKIPRWVfhlknlkelylsgcvlPEQLSSLHLEGfQDLK--------NLRTLYLKSS-LSRIPQV 555
Cdd:PRK15370  176 LKNNKTELRLKILGLTTIPACI----------------PEQITTLILDN-NELKslpenlqgNIKTLYANSNqLTSIPAT 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 556 VTDllpSLQKLSLDnegsklvvLNNLKKMVnlkslellscdlERIPHSifslnnLHELDLKENNLKTVEEiisfqHLPS- 634
Cdd:PRK15370  239 LPD---TIQEMELS--------INRITELP------------ERLPSA------LQSLDLFHNKISCLPE-----NLPEe 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 635 LSCLKLWHNNIAYIPAQIGalSNLEQLFLGHNNIESLPLQLFLctKLHYLDLSYNHLTFIPEEIQylTNLQYFAVTNNNI 714
Cdd:PRK15370  285 LRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETLPP--GLKTLEAGENALTSLPASLP--PELQVLDVSKNQI 358

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 715 EMLPDGLfqCKKLQCLLLGRNSLTDLSPLVGelSNLTHLELTGNYLETLPVEL-----EGCQSLKrscLIVEDSllnslp 789
Cdd:PRK15370  359 TVLPETL--PPTITTLDVSRNALTNLPENLP--AALQIMQASRNNLVRLPESLphfrgEGPQPTR---IIVEYN------ 425


                  ....*.
gi 1720414130 790 lPVAER 795
Cdd:PRK15370  426 -PFSER 430
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 455-773 1.01e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.19  E-value: 1.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 455 LPAAVAQLVNLRELHVYHSSLVVDHPALAFLEENLRILRL---KFTemGKIPRWVFHLKNLKELYLSGCVLPEQLSSLHL 531
Cdd:PLN00113  228 IPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLyqnKLS--GPIPPSIFSLQKLISLDLSDNSLSGEIPELVI 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 532 EgfqdLKNLRTLYLKSS--LSRIPQVVTDLlPSLQKLSL-DNEGS-----------KLVVL----NNLKKMV-------- 585
Cdd:PLN00113  306 Q----LQNLEILHLFSNnfTGKIPVALTSL-PRLQVLQLwSNKFSgeipknlgkhnNLTVLdlstNNLTGEIpeglcssg 380

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 586 NLKSLELLSCDLE-RIPHSIFSLNNLHELDLKENNLkTVEEIISFQHLPSLSCLKLWHNNI-AYIPAQIGALSNLEQLFL 663
Cdd:PLN00113  381 NLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSF-SGELPSEFTKLPLVYFLDISNNNLqGRINSRKWDMPSLQMLSL 459

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 664 GHNNIESLPLQLFLCTKLHYLDLSYNHLT-FIPEEIQYLTNLQYFAVTNNNIE-MLPDGLFQCKKLQCLLLGRNSLTDLS 741
Cdd:PLN00113  460 ARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQI 539

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1720414130 742 PL-VGELSNLTHLELTGNYLE-TLPVELEGCQSL 773
Cdd:PLN00113  540 PAsFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 500-775 1.58e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.42  E-value: 1.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 500 GKIPRWVFHLKNLKELYLSGCVLpeqlsslhlegfqdlknlrtlylkssLSRIPQVVTDlLPSLQKLSLDNEGSKLVVLN 579
Cdd:PLN00113  154 GEIPNDIGSFSSLKVLDLGGNVL--------------------------VGKIPNSLTN-LTSLEFLTLASNQLVGQIPR 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 580 NLKKMVNLKSLELLSCDLE-RIPHSIFSLNNLHELDLKENNLktveeiisfqhlpslsclklwhnnIAYIPAQIGALSNL 658
Cdd:PLN00113  207 ELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNL------------------------TGPIPSSLGNLKNL 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 659 EQLFLGHNNIE-SLPLQLFLCTKLHYLDLSYNHLTF-IPEEIQYLTNLQYFAVTNNNIE-MLPDGLFQCKKLQCLLLGRN 735
Cdd:PLN00113  263 QYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSGeIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSN 342

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720414130 736 SLT----------------DLSP--LVGEL-------SNLTHLELTGNYLET-LPVELEGCQSLKR 775
Cdd:PLN00113  343 KFSgeipknlgkhnnltvlDLSTnnLTGEIpeglcssGNLFKLILFSNSLEGeIPKSLGACRSLRR 408
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 609-758 2.15e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.12  E-value: 2.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 609 NLHELDLKENNLKTVEeiiSFQHLPSLSCLKLWHNNIAYIPaQIGALSNLEQLFLGHNNIESLPlQLFLCTKLHYLDLSY 688
Cdd:cd21340    25 NLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVVE-GLENLTNLEELHIEN 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 689 NHL------TFIPEEIQYLTN-LQYFAVTNNNIEMLpDGLFQCKKLQCLLLGRN---SLTDLSPLVGELSNLTHLELTGN 758
Cdd:cd21340   100 QRLppgeklTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNqisDLEELLDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 488-773 2.12e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.57  E-value: 2.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 488 NLRILRLKFTE-MGKIPRWVFHLKNLKELYLSGCVLPEQLSSlhleGFQDLKNLRTLYLK-SSLS-RIPQVVTDLLpSLQ 564
Cdd:PLN00113  165 SLKVLDLGGNVlVGKIPNSLTNLTSLEFLTLASNQLVGQIPR----ELGQMKSLKWIYLGyNNLSgEIPYEIGGLT-SLN 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 565 KLSLdnegsklvVLNNLKKMV-----NLKSLELLSCDLER----IPHSIFSLNNLHELDLKENNL--KTVEEIISFQH-- 631
Cdd:PLN00113  240 HLDL--------VYNNLTGPIpsslgNLKNLQYLFLYQNKlsgpIPPSIFSLQKLISLDLSDNSLsgEIPELVIQLQNle 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 632 -------------------LPSLSCLKLWHNNIA-YIPAQIGALSNLEQLFLGHNNI-----ESL--------------- 671
Cdd:PLN00113  312 ilhlfsnnftgkipvaltsLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLtgeipEGLcssgnlfklilfsns 391

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 672 -----PLQLFLCTKLHYLDLSYNHLTF-IPEEIQYLTNLQYFAVTNNNI---------EM----------------LPDg 720
Cdd:PLN00113  392 legeiPKSLGACRSLRRVRLQDNSFSGeLPSEFTKLPLVYFLDISNNNLqgrinsrkwDMpslqmlslarnkffggLPD- 470

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720414130 721 LFQCKKLQCLLLGRNSLTDLSPL-VGELSNLTHLELTGNYLE-TLPVELEGCQSL 773
Cdd:PLN00113  471 SFGSKRLENLDLSRNQFSGAVPRkLGSLSELMQLKLSENKLSgEIPDELSSCKKL 525
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 607-775 2.17e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.42  E-value: 2.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 607 LNNLHELDLKENNLKTVEEIISFqhlPSLSCLKLWHNNIAYIPaQIGALSNLEQLFLGHNNIESLPlQLFLCTKLHYLDL 686
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNLSLC---KNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 687 SYNHLTFIpEEIQYLTNLQYFAVTNNNiemLPDG---LFQC-------KKLQCLLLGRNSLTDLSPLVGeLSNLTHLELT 756
Cdd:cd21340    76 GGNRISVV-EGLENLTNLEELHIENQR---LPPGeklTFDPrslaalsNSLRVLNISGNNIDSLEPLAP-LRNLEQLDAS 150

                         170       180
                  ....*....|....*....|..
gi 1720414130 757 GNYL---ETLPVELEGCQSLKR 775
Cdd:cd21340   151 NNQIsdlEELLDLLSSWPSLRE 172
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
578-797 6.93e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 62.79  E-value: 6.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 578 LNNLKKMVNLKSLELLScdlerIPHSIfsLNNLHELDLKENNLKTVEEIISfqhlPSLSCLKLWHNNIAYIPAQIGalSN 657
Cdd:PRK15370  176 LKNNKTELRLKILGLTT-----IPACI--PEQITTLILDNNELKSLPENLQ----GNIKTLYANSNQLTSIPATLP--DT 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 658 LEQLFLGHNNIESLPLQLflCTKLHYLDLSYNHLTFIPEEIQylTNLQYFAVTNNNIEMLPDGLfqckklqclllgrnsl 737
Cdd:PRK15370  243 IQEMELSINRITELPERL--PSALQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAHL---------------- 302

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720414130 738 tdlsPlvgelSNLTHLELTGNYL----ETLPVELEgcqslkrsCLIVEDSLLNSLPLPVAERLQ 797
Cdd:PRK15370  303 ----P-----SGITHLNVQSNSLtalpETLPPGLK--------TLEAGENALTSLPASLPPELQ 349
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 428-692 8.17e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.01  E-value: 8.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 428 MLNG-LPDNVFELTEMevLSLEL--------IPEVklpaaVAQLVNLRELHVYHSSLVVDHP-ALAFLEEnLRILRL--- 494
Cdd:PLN00113  271 KLSGpIPPSIFSLQKL--ISLDLsdnslsgeIPEL-----VIQLQNLEILHLFSNNFTGKIPvALTSLPR-LQVLQLwsn 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 495 KFTemGKIPRWVFHLKNLKELYLSGCVLPEQLSslhlEGFQDLKNLRTLYLKS-SL-SRIPQVVTDLlPSLQKLSLDNEG 572
Cdd:PLN00113  343 KFS--GEIPKNLGKHNNLTVLDLSTNNLTGEIP----EGLCSSGNLFKLILFSnSLeGEIPKSLGAC-RSLRRVRLQDNS 415

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 573 SKLVVLNNLKKMVNLKSLELLSCDLE-RIPHSIFSLNNLHELDLKENNLktveeiisFQHLP------SLSCLKLWHNNI 645
Cdd:PLN00113  416 FSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKF--------FGGLPdsfgskRLENLDLSRNQF 487

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1720414130 646 A-YIPAQIGALSNLEQLFLGHNNIES-LPLQLFLCTKLHYLDLSYNHLT 692
Cdd:PLN00113  488 SgAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLS 536
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 531-760 2.85e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 53.64  E-value: 2.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 531 LEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSL--QKLSLDNEGS-KLVVLNNLKKMVNLKSLELLSCDLERIPHSIFSL 607
Cdd:COG5238   128 EDSLILYLALPRRINLIQVLKDPLGGNAVHLLGlaARLGLLAAISmAKALQNNSVETVYLGCNQIGDEGIEELAEALTQN 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 608 NNLHELDLKENNL--KTVEEIIS-FQHLPSLSCLKLWHNNI--AYIPAQIGAL---SNLEQLFLGHNNI-----ESLPLQ 674
Cdd:COG5238   208 TTVTTLWLKRNPIgdEGAEILAEaLKGNKSLTTLDLSNNQIgdEGVIALAEALknnTTVETLYLSGNQIgaegaIALAKA 287

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 675 LFLCTKLHYLDLSYNHLTFipeeiqyltnlqyfavtnNNIEMLPDGLFQCKKLQCLLLGRNSLTD-----LSPLVGELSN 749
Cdd:COG5238   288 LQGNTTLTSLDLSVNRIGD------------------EGAIALAEGLQGNKTLHTLNLAYNGIGAqgaiaLAKALQENTT 349

                         250
                  ....*....|.
gi 1720414130 750 LTHLELTGNYL 760
Cdd:COG5238   350 LHSLDLSDNQI 360
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 410-790 5.01e-07

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 53.73  E-value: 5.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130  410 LKSKLVKNSQDKVELHLFMLNGLPDNVFELtEMEVLSLElipevKLPAAVAQLVNLRELHVYHSSLVVDHPALAfLEENL 489
Cdd:PLN03210   587 LPPKLRLLRWDKYPLRCMPSNFRPENLVKL-QMQGSKLE-----KLWDGVHSLTGLRNIDLRGSKNLKEIPDLS-MATNL 659

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130  490 RILRL-KFTEMGKIPRWVFHLKNLKELYLSGC----VLP-----EQLSSLHLEGFQDLKNLRTLYLKSSLSRIPQVVTDL 559
Cdd:PLN03210   660 ETLKLsDCSSLVELPSSIQYLNKLEDLDMSRCenleILPtginlKSLYRLNLSGCSRLKSFPDISTNISWLDLDETAIEE 739

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130  560 LPSlqKLSLDNegSKLVVLNNLKKMVNLKSLELLSCDLERIPHSifslnnLHELDLkENNLKTVEEIISFQHLPSLSCLK 639
Cdd:PLN03210   740 FPS--NLRLEN--LDELILCEMKSEKLWERVQPLTPLMTMLSPS------LTRLFL-SDIPSLVELPSSIQNLHKLEHLE 808

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130  640 LWH-NNIAYIPAQIGaLSNLEQLFLGH-NNIESLPlqlFLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVTN-NNIEM 716
Cdd:PLN03210   809 IENcINLETLPTGIN-LESLESLDLSGcSRLRTFP---DISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGcNNLQR 884

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130  717 LPDGLFQCKKLQ------CLLLGRNSLTDLSPLVGELSNLTHLELTgnylETLPVELEGCQSLKRSCLIVEDSLLNSLPL 790
Cdd:PLN03210   885 VSLNISKLKHLEtvdfsdCGALTEASWNGSPSEVAMATDNIHSKLP----STVCINFINCFNLDQEALLQQQSIFKQLIL 960
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 508-618 7.42e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 7.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 508 HLKNLKELYLSGcvlpEQLSslHLEGFQDLKNLRTLYLKS-------SLSRIPQVVTDLLPSLQKLSLdnEGSKLVVLNN 580
Cdd:cd21340    66 NLVNLKKLYLGG----NRIS--VVEGLENLTNLEELHIENqrlppgeKLTFDPRSLAALSNSLRVLNI--SGNNIDSLEP 137

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1720414130 581 LKKMVNLKSLELLSCDLERIP---HSIFSLNNLHELDLKEN 618
Cdd:cd21340   138 LAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 597-777 6.49e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.89  E-value: 6.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 597 LERIPHSIFSLNNLHELDLKENNL--KTVEEIISFQHLPSLSCLKLWHNNIAYIPAQI--GAL----SNLEQLFLGHNNI 668
Cdd:cd00116    70 LQSLLQGLTKGCGLQELDLSDNALgpDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLlaKGLkdlpPALEKLVLGRNRL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 669 -----ESLPLQLFLCTKLHYLDLSYNHLTfiPEEIQYLT------------NLQYFAVTNNNIEMLPDGLFQCKKLQCLL 731
Cdd:cd00116   150 egascEALAKALRANRDLKELNLANNGIG--DAGIRALAeglkancnlevlDLNNNGLTDEGASALAETLASLKSLEVLN 227

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720414130 732 LGRNSLTD------LSPLVGELSNLTHLELTGNYLetlpvELEGCQSLKRSC 777
Cdd:cd00116   228 LGDNNLTDagaaalASALLSPNISLLTLSLSCNDI-----TDDGAKDLAEVL 274
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 508-692 2.15e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 2.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 508 HLKNLKELYLSGcvlpEQLSSLhlEGFQDLKNLRTLYLksSLSRIpQVVTDL--LPSLQKLSLDNegsklvvlnnlkkmV 585
Cdd:cd21340    44 FLTNLTHLYLQN----NQIEKI--ENLENLVNLKKLYL--GGNRI-SVVEGLenLTNLEELHIEN--------------Q 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 586 NLKSLELLSCDleriPHSIFSL-NNLHELDLKENNLKTVEEiisfqhlpsLSCLKlwhnniayipaqigalsNLEQLFLG 664
Cdd:cd21340   101 RLPPGEKLTFD----PRSLAALsNSLRVLNISGNNIDSLEP---------LAPLR-----------------NLEQLDAS 150

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1720414130 665 HNNIESL-PLQLFL--CTKLHYLDLSYNHLT 692
Cdd:cd21340   151 NNQISDLeELLDLLssWPSLRELDLTGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
702-760 2.28e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.28e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720414130 702 TNLQYFAVTNNNIEMLPDGLFQ-CKKLQCLLLGRNSLTDLSP--LVGeLSNLTHLELTGNYL 760
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPgaFSG-LPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
586-645 4.02e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 4.02e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720414130 586 NLKSLELLSCDLERIPHSIFS-LNNLHELDLKENNLKTVEEiISFQHLPSLSCLKLWHNNI 645
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
633-691 4.48e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 4.48e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720414130 633 PSLSCLKLWHNNIAYI-PAQIGALSNLEQLFLGHNNIESLPLQLFLC-TKLHYLDLSYNHL 691
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
633-773 7.27e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 43.23  E-value: 7.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 633 PSLSCLKLWHNNIAYIPAqigALSNLEQLFLGHNNIESLPLqlfLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVTNN 712
Cdd:PRK15387  302 PGLQELSVSDNQLASLPA---LPSELCKLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLT 375

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720414130 713 NIEMLPDGLFQckklqcLLLGRNSLTDLSPLVGELSNLThleLTGNYLETLPVELEGCQSL 773
Cdd:PRK15387  376 SLPALPSGLKE------LIVSGNRLTSLPVLPSELKELM---VSGNRLTSLPMLPSGLLSL 427
LRR_8 pfam13855
Leucine rich repeat;
679-737 1.17e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.17e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720414130 679 TKLHYLDLSYNHLTFIPEEI-QYLTNLQYFAVTNNNIEMLPDGLFQC-KKLQCLLLGRNSL 737
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
511-570 1.62e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.62e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720414130 511 NLKELYLSGCvlpeQLSSLHLEGFQDLKNLRTLYLKS-SLSRIPQVVTDLLPSLQKLSLDN 570
Cdd:pfam13855   2 NLRSLDLSNN----RLTSLDDGAFKGLSNLKVLDLSNnLLTTLSPGAFSGLPSLRYLDLSG 58
PLN03150 PLN03150
hypothetical protein; Provisional
 693-769 2.45e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.34  E-value: 2.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130 693 FIPEEIQYLTNLQYFAVTNNNIE-MLPDGLFQCKKLQCLLLGRNSLTDLSP-LVGELSNLTHLELTGNYLE-TLPVELEG 769
Cdd:PLN03150  433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPeSLGQLTSLRILNLNGNSLSgRVPAALGG 512
LRR_8 pfam13855
Leucine rich repeat;
488-545 3.94e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 3.94e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720414130 488 NLRILRLKFTEMGKI-PRWVFHLKNLKELYLSGcvlpEQLSSLHLEGFQDLKNLRTLYL 545
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSN----NLLTTLSPGAFSGLPSLRYLDL 56
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 529-774 7.42e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.86  E-value: 7.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130  529 LHLEGFQDLKNLrtLYLKSSLSR----------IPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKmvNLKSLELLSCDLE 598
Cdd:PLN03210   549 IHENAFKGMRNL--LFLKFYTKKwdqkkevrwhLPEGFDYLPPKLRLLRWDKYPLRCMPSNFRPE--NLVKLQMQGSKLE 624

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130  599 RIPHSIFSLNNLHELDL-KENNLKtveEIISFQHLPSLSCLKLWH-NNIAYIPAQIGALSNLEQLFL-GHNNIESLP--- 672
Cdd:PLN03210   625 KLWDGVHSLTGLRNIDLrGSKNLK---EIPDLSMATNLETLKLSDcSSLVELPSSIQYLNKLEDLDMsRCENLEILPtgi 701

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414130  673 -------LQLFLCTKLH----------YLDLSYNHLTFIPEEIQyLTNLQYFAVTNNNIEMLPDGLFQCKKLQCLL---L 732
Cdd:PLN03210   702 nlkslyrLNLSGCSRLKsfpdistnisWLDLDETAIEEFPSNLR-LENLDELILCEMKSEKLWERVQPLTPLMTMLspsL 780

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720414130  733 GRNSLTDLSPLV---GELSNLTHLELTG----NYLETLP----------VELEGCQSLK 774
Cdd:PLN03210   781 TRLFLSDIPSLVelpSSIQNLHKLEHLEiencINLETLPtginleslesLDLSGCSRLR 839
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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