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Conserved domains on  [gi|1720418059|ref|XP_030111283|]
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zinc finger protein 384 isoform X8 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
140-295 8.01e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 8.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720418059 140 TKPHKCPHCSKTFANSSYLAQHIR--IHSG--AKPYSCNF--CEKSFRQLSHLQQHTRIHSKMHTETIKPHKCPHcSKTF 213
Cdd:COG5048   287 SLPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSS-KFSP 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720418059 214 ANTSYLAQHLRIHSGAKPYNCSY-----CQKAFRQLSHLQQHTRIHTGDRPYKCAHPGCEKAFTQLSNLQSHRRQHNKDK 288
Cdd:COG5048   366 LLNNEPPQSLQQYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHA 445


                  ....*..
gi 1720418059 289 PFKCHNC 295
Cdd:COG5048   446 PLLCSIL 452
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
140-295 8.01e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 8.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720418059 140 TKPHKCPHCSKTFANSSYLAQHIR--IHSG--AKPYSCNF--CEKSFRQLSHLQQHTRIHSKMHTETIKPHKCPHcSKTF 213
Cdd:COG5048   287 SLPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSS-KFSP 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720418059 214 ANTSYLAQHLRIHSGAKPYNCSY-----CQKAFRQLSHLQQHTRIHTGDRPYKCAHPGCEKAFTQLSNLQSHRRQHNKDK 288
Cdd:COG5048   366 LLNNEPPQSLQQYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHA 445


                  ....*..
gi 1720418059 289 PFKCHNC 295
Cdd:COG5048   446 PLLCSIL 452
zf-H2C2_2 pfam13465
Zinc-finger double domain;
157-182 4.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.84e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720418059 157 YLAQHIRIHSGAKPYSCNFCEKSFRQ 182
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
140-295 8.01e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 8.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720418059 140 TKPHKCPHCSKTFANSSYLAQHIR--IHSG--AKPYSCNF--CEKSFRQLSHLQQHTRIHSKMHTETIKPHKCPHcSKTF 213
Cdd:COG5048   287 SLPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSS-KFSP 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720418059 214 ANTSYLAQHLRIHSGAKPYNCSY-----CQKAFRQLSHLQQHTRIHTGDRPYKCAHPGCEKAFTQLSNLQSHRRQHNKDK 288
Cdd:COG5048   366 LLNNEPPQSLQQYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHA 445


                  ....*..
gi 1720418059 289 PFKCHNC 295
Cdd:COG5048   446 PLLCSIL 452
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
140-342 1.23e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720418059 140 TKPHKCPHCSKTFANSSYLAQHIRIHSGAKPYSCNFCEKSFRQLSHlqqhTRIHSKMHTETIKPHKCPHCSKTFANTSYL 219
Cdd:COG5048   230 TTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSP----NESDSSSEKGFSLPIKSKQCNISFSRSSPL 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720418059 220 AQHLR--IHSG--AKPYNC--SYCQKAFRQLSHLQQHTRIHTGDRPYKCAHPGCEKAFTQLSN-----LQSHRRQHNKDK 288
Cdd:COG5048   306 TRHLRsvNHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNneppqSLQQYKDLKNDK 385

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720418059 289 PFKC--HNCHRAYTDAASLEAHLSTHTVKHAKVYTCTICSRAYTSETYLMKHMRKH 342
Cdd:COG5048   386 KSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIH 441
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 256-308 3.00e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 3.00e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720418059 256 GDRPYKCAHPGCEKAFTQLSNLQSHRRQ---------------HN----KDKPFKCHNCHRAYTDAASLEAH 308
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHMLHghqnqklhenpspekMNifsaKDKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
157-182 4.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.84e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720418059 157 YLAQHIRIHSGAKPYSCNFCEKSFRQ 182
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
246-273 6.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.06e-03
                          10        20
                  ....*....|....*....|....*...
gi 1720418059 246 HLQQHTRIHTGDRPYKCahPGCEKAFTQ 273
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
129-154 7.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.91e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720418059 129 EMQIHSKSHTETKPHKCPHCSKTFAN 154
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 143-165 8.11e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.11e-03
                          10        20
                  ....*....|....*....|...
gi 1720418059 143 HKCPHCSKTFANSSYLAQHIRIH 165
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
230-290 8.95e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 8.95e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720418059 230 KPYNCSYCQKAFRQLSHLQQHTRIHTGDRPYKCAHPGCEKAFTQLSNLQSHRRQHNKDKPF 290
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSD 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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