|
Name |
Accession |
Description |
Interval |
E-value |
| Sema_plexin_B1 |
cd11275 |
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ... |
27-489 |
0e+00 |
|
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200536 [Multi-domain] Cd Length: 461 Bit Score: 942.85 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 27 FSHNATKFLHLSMDLESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHHTDNHNKLLLVNPVQ 106
Cdd:cd11275 1 FSPNGTKFLHLSMDPESGTLYLGATNFLFQLTPDLLLENMVQTGPVLDSKDCLPPVSKLECPQAQHTNNHNKLLLVNPVQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 107 KELIVCGSVHQGICEKRSLASIDHVLFRPESPGDTQYVAANDPNITTVGLIAYSKDEVPLLFVGRGYTSRGVGGGIPPIT 186
Cdd:cd11275 81 KELIVCGSVHQGICEKRRLGSIDHVLFRPERPGDTQYVAANDPNVTTVGLVAYSKDGVPLLFVGRGYTSRGVGGGIPPIT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 187 TRNLRAHGGDvqATDSHSIFSYEETAKLAVGRLSEYNHHFIKSFTYHSSVYFLFYRRDLKSQSREYKTYISRICLDDSHY 266
Cdd:cd11275 161 TRNLRAHGDD--ATDSHSIFSYEETAKLAVGRLSEYNHHFIKAFTYGSSVYFLFYRRDLKSQSREYKTYISRICLDDSHY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 267 YSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQGQLDTEGEVLFAAFSAWQASSGKLSEESALCVYTMEEVDRLTNWTR 346
Cdd:cd11275 239 YSYVELPLLCQSKANTYSLLQAAYVTQPGERLAQGQLDTDGEVLFAAFSAWQASSGKLSEESALCAYPMDEVDRLTNWTR 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 347 DVCYMRDGKSEEGTEVAYIEYDVSSNCVQLPADTLYAYPCGSDHTPSPMASRVPLEAAPLLEKTEARLTAVAVNVEDGHT 426
Cdd:cd11275 319 DVCYTRDGKAEDGTEVAYIEYDVSSNCVQLPADTLDAYPCGSDHTPSPMASRVPLEATPLLEWTEIRLTAVAVNVEDGHT 398
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2043825702 427 IAFLGDSRGRLHKVYLGAQGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPIM 489
Cdd:cd11275 399 IAFLGDSRGRLHKVYLGAGGDAHTYSSQSIQQNSAVSGDLLFDQLQEHLYVMTQSTVLKVPIA 461
|
|
| Plexin_cytopl |
pfam08337 |
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ... |
1632-2168 |
0e+00 |
|
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.
Pssm-ID: 462434 [Multi-domain] Cd Length: 500 Bit Score: 894.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1632 GIPFLDYKSYAERIFFPGHRESPLQRDLDIP---ECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVA 1708
Cdd:pfam08337 1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPvtnDGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1709 SLLTVSLHGKLEYFTDILKTLLNDLVEQYV-AKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQ 1787
Cdd:pfam08337 81 SLLMVALHGKLEYATEILKTLLRDLIDKSVeSKNPKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1788 VDKGPVDWVTGKAKYTLNDNRLLREDLEYRTLTLNALTQAGvgaggaEDSQGISAKVLDCDTITQVKEKILDQIYKGTPY 1867
Cdd:pfam08337 161 VEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEG------ENSESVPVKVLDCDTITQVKEKILDAIYKNTPY 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1868 CHRPDPDTLDLEWRSGLAGHLILSDEDVTSVVQGTWKRLNTLQHYKVPDGATVALVPrltkhihrenqdyipgektpmle 1947
Cdd:pfam08337 235 SQRPSIDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP----------------------- 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1948 dadeggiKLWHLVKPTEEPELPKHrrgslrDRERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST-NRPVPLAVKYFF 2026
Cdd:pfam08337 292 -------KYWHLVKPSDEGDQRKK------SERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVpNSALPLAVKYLF 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 2027 DLLDEQAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINK 2106
Cdd:pfam08337 359 DFLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEHRLGKDSPSNK 438
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2043825702 2107 LLYARDIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKYINK 2168
Cdd:pfam08337 439 LLYAKDIPRYKQMVERYYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
|
|
| RasGAP_plexin_B1 |
cd12793 |
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane ... |
1632-2205 |
0e+00 |
|
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D and plexin-B1 signaling complex regulates dendritic and axonal complexity. The activation of Plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin-B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin-B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin-B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213353 [Multi-domain] Cd Length: 394 Bit Score: 797.70 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1632 GIPFLDYKSYAERIFFPGHRESPLQRDLDIPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVASLL 1711
Cdd:cd12793 1 GIPFLDYRMYAERIFFPGHRESPLRRDLDVPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLESQRTFSPRDRAYVASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1712 TVSLHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQVDKG 1791
Cdd:cd12793 81 TVALHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFLRDSAGESLYMLFRAIKHQVDKG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1792 PVDWVTGKakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtitqvkekildqiykgtpychrp 1871
Cdd:cd12793 161 PVDAVTGK------------------------------------------------------------------------ 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1872 dpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpmledade 1951
Cdd:cd12793 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1952 ggiklwhlvkpteepelpkhrrgslrdrERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTNRPVPLAVKYFFDLLDE 2031
Cdd:cd12793 169 ----------------------------ERAKAIPEIYLTRLLSMKGTLQKFVDDLFTVILSTSRPVPLAVKYFFDLLDE 220
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 2032 QAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINKLLYAR 2111
Cdd:cd12793 221 QALQHGISDPETIHIWKTNSLPLRFWINIIKNPQFIFDVQTSDNVDAVLSVIAQTFMDSCTIADHKLGRDSPINKLLYAR 300
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 2112 DIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKYINKYYDQIITALEEDPTAQKMQLGYR 2191
Cdd:cd12793 301 DIPRYKQMVERYYADIRQTVSASDQEMNSALAELSRNYSGELNYLVALHELYKYINKYYDQIITALEEDSTAQKMQLGYR 380
|
570
....*....|....
gi 2043825702 2192 LQQIAAAVENKVTD 2205
Cdd:cd12793 381 LQQIAAAVENKVTD 394
|
|
| Sema |
smart00630 |
semaphorin domain; |
34-456 |
9.26e-69 |
|
semaphorin domain;
Pssm-ID: 214747 [Multi-domain] Cd Length: 390 Bit Score: 237.65 E-value: 9.26e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 34 FLHLSMDLESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKlecPQAHHTDNHNKL-LLVNPVQKELIVC 112
Cdd:smart00630 1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECVSK---GKDPPTDCVNYIrLLLDYNEDRLLVC 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 113 GS-VHQGICEKRSLasidhvlfrpespgdtqyvaandpnittvgliayskdevPLLFVGRGYTSRGVGGGIPP-ITTRNL 190
Cdd:smart00630 78 GTnAFQPVCRLRNL---------------------------------------GELYVGTVADFSGSDPAIPRsLSVRRL 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 191 RAHGGDVQATDSHSIFSYeetaklavgrlseYNHHFIKSFTYHSSVYFLFYRR--DLKSQSREYKTYISRICLDD----- 263
Cdd:smart00630 119 KGTSGVSLRTVLYDSKWL-------------NEPNFVYAFESGDFVYFFFRETavEDDNCGKAVHSRVARVCKNDvggpr 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 264 ---SHYYSYVELPLLCQSKANT---YSLLQAAYVTRPGKElaqgqldtEGEVLFAAFSAWQASSGKlseeSALCVYTMEE 337
Cdd:smart00630 186 sldKKWTSFLKARLECSVPGEDpfyFNELQAAFLLPPGSE--------SDDVLYGVFSTSSNPIPG----SAVCAFSLSD 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 338 VDRLTNWTRDVCYMRDGKSEEGTEvAYIEYDVSSNCVQLPADTLyAYPC----GSDHTPSPMASRVPLEAAPLLEKT--E 411
Cdd:smart00630 254 INAVFNGPFKECETSTSQWLPYSR-GKVPYPRPGTCPNKPPSSK-DLPDetlnFIKSHPLMDEVVQPLTGRPLFVKTdsN 331
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 2043825702 412 ARLTAVAVNVED---GHTIAFLGDSRGRLHKVYL---GAQGEAHTYASVSI 456
Cdd:smart00630 332 YLLTSIAVDRVAtdgNYTVLFLGTSDGRILKVVLsesSSSSESVVLEEISV 382
|
|
| IPT_plexin_repeat1 |
cd01180 |
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ... |
1141-1232 |
5.76e-28 |
|
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238585 Cd Length: 94 Bit Score: 109.33 E-value: 5.76e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1141 PLIHSVYPLSGPVEGGTRITITGSNLGQKHQDIAETVTVAGIPCAVDAQEYEISSSIVCITGGSWTERFGHiVVEVPGGG 1220
Cdd:cd01180 1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPVFNG-PVEVTVGH 79
|
90
....*....|....*
gi 2043825702 1221 ---RGVSGHVFTYQN 1232
Cdd:cd01180 80 gsfRTESSEGFSFVD 94
|
|
| TIG_plexin |
pfam17960 |
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ... |
549-636 |
7.55e-27 |
|
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.
Pssm-ID: 465588 Cd Length: 89 Bit Score: 105.81 E-value: 7.55e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 549 TPANISREEKRNIFLAISDLPSLreEEFYSCYFEDY-ESPAVLTESGIMCPSPDPSQAPALPTGTDHVTIKLVVRF--HD 625
Cdd:pfam17960 1 TPDNISRTTATQLTLTVPNLPAL--SEGYSCVFGDLtESPATVHDNGVKCATPPPSQLPPIPTGQDHVTVKLSLRSseTG 78
|
90
....*....|.
gi 2043825702 626 IFIASVDFSFY 636
Cdd:pfam17960 79 VDFASTNFTFY 89
|
|
| Sema |
pfam01403 |
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ... |
286-469 |
1.25e-25 |
|
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805
Pssm-ID: 460197 [Multi-domain] Cd Length: 180 Bit Score: 105.82 E-value: 1.25e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 286 LQAAYVTRPGKELAQGqldtegEVLFAAFSAWQASSgklSEESALCVYTMEEVDRLTNwTRDVCYMRDGkSEEGTEVAYI 365
Cdd:pfam01403 1 LQDVFVLKPGAGDALD------TVLYGVFTTQWSNS---IGGSAVCAFSLSDINAVFE-GPFKEQEKSD-SKWLPYTGKV 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 366 EYDVSSNCV------QLPADTLyaypCGSDHTPSPMASRVPLEAAPLLEKTEARLTAVAVN---VEDG-HTIAFLGDSRG 435
Cdd:pfam01403 70 PYPRPGTCIndplrlDLPDSVL----NFVKDHPLMDEAVQPVGGRPLLVRTGVRLTSIAVDrvqALDGnYTVLFLGTDDG 145
|
170 180 190
....*....|....*....|....*....|....*
gi 2043825702 436 RLHKVYLGAQGEAHTYASVSI-QVNSMVSGDLLFD 469
Cdd:pfam01403 146 RLHKVVLVGSEESHIIEEIQVfPEPQPVLNLLLSS 180
|
|
| TIG_2 |
pfam18020 |
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ... |
994-1093 |
3.04e-23 |
|
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.
Pssm-ID: 465619 Cd Length: 94 Bit Score: 95.81 E-value: 3.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 994 GSSLFPVNVARKITLLGKNFHLYQDQQWDYECVLNLEGRTVVMEAYVEGEETnkslcyITCQMNQYSYTAPQLEFSAMVF 1073
Cdd:pfam18020 1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDS------ITCQEHQFSYSGSSGELPATFY 74
|
90 100
....*....|....*....|
gi 2043825702 1074 VQRRRHLRVDSAADLHVTFY 1093
Cdd:pfam18020 75 VTWNGGHRLDNPANLQVVLY 94
|
|
| IPT_plexin_repeat3 |
cd01181 |
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ... |
1323-1445 |
3.99e-20 |
|
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238586 Cd Length: 99 Bit Score: 87.09 E-value: 3.99e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1323 PNITFAEPPKSFLSGGRVLRVHGYNLDVVQKPKIRVTVspserrrrgvgrwrriipdsecpedslcsIQQFEEPCLVNSS 1402
Cdd:cd01181 1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKY-----------------------------GGVEKTSCKVRNS 51
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 2043825702 1403 YLILCKTPAINLLLRS---VRIKLEFILDNLSF-DFNSLHPMPFSYE 1445
Cdd:cd01181 52 TLMTCPAPSLALLNRSpepGERPVEFGLDGDNVqSLLILNRTSFSYY 98
|
|
| IPT_plexin_repeat2 |
cd01179 |
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ... |
1233-1320 |
1.01e-16 |
|
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238584 Cd Length: 85 Bit Score: 76.88 E-value: 1.01e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1233 PELKSIVPTQGPKAGGTCLTLLGSKLLTGhpNEISVLLGDLPCQILSEmTEDQLACQTSPSNVSTELPVIIKYGeQERRL 1312
Cdd:cd01179 1 PSITSLSPSYGPQSGGTRLTITGKHLNAG--SSVRVTVGGQPCKILSV-SSSQIVCLTPPSASPGEAPVKVLID-GARRL 76
|
....*...
gi 2043825702 1313 EGSLFRYT 1320
Cdd:cd01179 77 APLVFTYT 84
|
|
| PSI |
pfam01437 |
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ... |
491-540 |
4.96e-14 |
|
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).
Pssm-ID: 396154 [Multi-domain] Cd Length: 52 Bit Score: 68.12 E-value: 4.96e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 2043825702 491 CSLYLDCESCLALKDPYCGWCVLQGRCSRRSECLRSRlSEQWLWSFNSTQ 540
Cdd:pfam01437 2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPE-GNCEEWEQASSK 50
|
|
| TIG |
pfam01833 |
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ... |
1141-1230 |
5.35e-14 |
|
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.
Pssm-ID: 460355 [Multi-domain] Cd Length: 84 Bit Score: 69.01 E-value: 5.35e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1141 PLIHSVYPLSGPVEGGTRITITGSNLGQKHQDIaeTVTVAGIPCAVDAQeyeISSSIVCITGGSWTERFGhIVVEVPGGG 1220
Cdd:pfam01833 1 PVITSISPSSGPASGGTTITITGSNFGTDSSDL--KVTIGGTPCTVISV---SSTTIVCTTPPGTSGLVN-VSVTVGGGG 74
|
90
....*....|
gi 2043825702 1221 RGVSGHVFTY 1230
Cdd:pfam01833 75 ISSSPLTFTY 84
|
|
| IPT |
smart00429 |
ig-like, plexins, transcription factors; |
1141-1230 |
9.23e-13 |
|
ig-like, plexins, transcription factors;
Pssm-ID: 214657 [Multi-domain] Cd Length: 90 Bit Score: 65.90 E-value: 9.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1141 PLIHSVYPLSGPVEGGTRITITGSNLGqKHQDIAETVTVAGIPCAVDAQEyeiSSSIVCITGGSWTERFGHIVVEVPGGG 1220
Cdd:smart00429 2 PVITRISPTSGPVSGGTEITLCGKNLK-SISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHNIPGSVPVRTVGLRN 77
|
90
....*....|..
gi 2043825702 1221 RGVSG--HVFTY 1230
Cdd:smart00429 78 GGVPSspQPFTY 89
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
686-1007 |
1.23e-12 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 72.69 E-value: 1.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 686 AQIPTSivyPSSAAPLTKSSTTaPTTAPKPVTTPVLVGPSTVPHTEAiHVTPSAASEPTTTTEPTQSPGYTPLTLSTEAA 765
Cdd:pfam17823 112 SRALAA---AASSSPSSAAQSL-PAAIAALPSEAFSAPRAAACRANA-SAAPRAAIAAASAPHAASPAPRTAASSTTAAS 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 766 SLQAATESPLPLPADKPAVTVP-QTTSPAASVLSNPSKNMDHIALPTEGPA--TAQDAWHTDPPTTLGGSPLHTSPVAAV 842
Cdd:pfam17823 187 STTAASSAPTTAASSAPATLTPaRGISTAATATGHPAAGTALAAVGNSSPAagTVTAAVGTVTPAALATLAAAAGTVASA 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 843 -----TPSPQVTSfkwpPSPFPTTEALTSAiSSPQTPS--QVPGSPV-VSDDAPGLPGTelpvsGLPTSAPPQWLLEEGT 914
Cdd:pfam17823 267 agtinMGDPHARR----LSPAKHMPSDTMA-RNPAAPMgaQAQGPIIqVSTDQPVHNTA-----GEPTPSPSNTTLEPNT 336
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 915 ElqdtedwmdllQAENDTSLFSASTLLSGDGDSSERDVPDFPRILHPDLdyqydapefweESEEPSWGPNACPCVQGIQG 994
Cdd:pfam17823 337 P-----------KSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEV-----------EATSPTTQPSPLLPTQGAAG 394
|
330
....*....|....*
gi 2043825702 995 SS--LFPVNVARKIT 1007
Cdd:pfam17823 395 PGilLAPEQVATEAT 409
|
|
| PSI |
smart00423 |
domain found in Plexins, Semaphorins and Integrins; |
490-527 |
4.69e-12 |
|
domain found in Plexins, Semaphorins and Integrins;
Pssm-ID: 214655 [Multi-domain] Cd Length: 47 Bit Score: 62.56 E-value: 4.69e-12
10 20 30
....*....|....*....|....*....|....*...
gi 2043825702 490 ECSLYLDCESCLALKDPYCGWCVLQGRCSRRSECLRSR 527
Cdd:smart00423 1 RCSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRR 38
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
685-907 |
1.58e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 67.27 E-value: 1.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 685 RAQIPTSIVYPSSAA--PLTKSSTTAPTTAPKPVTTPVLVGPSTVPHTEAIHVTPSAASEPTTTTEPTQSP--GYTPLTL 760
Cdd:PHA03247 2609 RGPAPPSPLPPDTHApdPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPpqRPRRRAA 2688
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 761 STEAASLQAATESPLPLPADKPAVT-----VPQTTSPAASVLSNPSKNMDHIALPT-EGPAT-AQDAWHTDPPTTlGGSP 833
Cdd:PHA03247 2689 RPTVGSLTSLADPPPPPPTPEPAPHalvsaTPLPPGPAAARQASPALPAAPAPPAVpAGPATpGGPARPARPPTT-AGPP 2767
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2043825702 834 LHTSPVAAVTPSPQVTsfkwPPSPFPTTEALTSAISSPQTPSQVPGspVVSDDAPGLPGTELPVSGLPTSAPPQ 907
Cdd:PHA03247 2768 APAPPAAPAAGPPRRL----TRPAVASLSESRESLPSPWDPADPPA--AVLAPAAALPPAASPAGPLPPPTSAQ 2835
|
|
| TIG |
pfam01833 |
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ... |
1233-1319 |
3.22e-08 |
|
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.
Pssm-ID: 460355 [Multi-domain] Cd Length: 84 Bit Score: 52.83 E-value: 3.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1233 PELKSIVPTQGPKAGGTCLTLLGSKLLTGHPNeISVLLGDLPCQILSeMTEDQLACQTsPSNVSTELPVIIKYGEQERRL 1312
Cdd:pfam01833 1 PVITSISPSSGPASGGTTITITGSNFGTDSSD-LKVTIGGTPCTVIS-VSSTTIVCTT-PPGTSGLVNVSVTVGGGGISS 77
|
....*..
gi 2043825702 1313 EGSLFRY 1319
Cdd:pfam01833 78 SPLTFTY 84
|
|
| IPT |
smart00429 |
ig-like, plexins, transcription factors; |
1322-1444 |
7.00e-08 |
|
ig-like, plexins, transcription factors;
Pssm-ID: 214657 [Multi-domain] Cd Length: 90 Bit Score: 52.04 E-value: 7.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1322 DPNITFAEPPKSFLSGGRVLRVHGYNLDVVQKPKIRVTVSPSErrrrgvgrwrriipdsecpedslCSIQQfeepclvNS 1401
Cdd:smart00429 1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAP-----------------------CTFSP-------SS 50
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2043825702 1402 SYLILCKTPAINLLLRSVRI-KLEFILDNLSFDfnslhPMPFSY 1444
Cdd:smart00429 51 STAIVCKTPPYHNIPGSVPVrTVGLRNGGVPSS-----PQPFTY 89
|
|
| Chi1 |
COG3469 |
Chitinase [Carbohydrate transport and metabolism]; |
693-896 |
2.63e-07 |
|
Chitinase [Carbohydrate transport and metabolism];
Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 55.91 E-value: 2.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 693 VYPSSAAPLTKSSTTAPTTAPKPVTTPVLVGPSTVPHTEAIHVTPSAASEPTTTTEPTQSPGYTPLTLSTEAASLQAATE 772
Cdd:COG3469 12 AGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATS 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 773 SPLPLPADKPAVTVPQTTSPAASVLSNPSKNMDhIALPTEGPATAQDAWHTDPPTTLGGSPLHTSPVAAVTPSPQVTSFK 852
Cdd:COG3469 92 TSATLVATSTASGANTGTSTVTTTSTGAGSVTS-TTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTT 170
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 2043825702 853 WPPSPFPTTEALTSAISSPQTPSQVPGSPVVSDDAPGlPGTELP 896
Cdd:COG3469 171 TTTSASTTPSATTTATATTASGATTPSATTTATTTGP-PTPGLP 213
|
|
| IPT |
smart00429 |
ig-like, plexins, transcription factors; |
1232-1320 |
8.03e-07 |
|
ig-like, plexins, transcription factors;
Pssm-ID: 214657 [Multi-domain] Cd Length: 90 Bit Score: 48.96 E-value: 8.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1232 NPELKSIVPTQGPKAGGTCLTLLGSKLLTGHPNEISVLLGDLPCQILSEmTEDQLACQTSPSNVST-ELPVI-IKYGEQE 1309
Cdd:smart00429 1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAPCTFSPS-SSTAIVCKTPPYHNIPgSVPVRtVGLRNGG 79
|
90
....*....|.
gi 2043825702 1310 RRLEGSLFRYT 1320
Cdd:smart00429 80 VPSSPQPFTYV 90
|
|
| PSI |
pfam01437 |
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ... |
1094-1133 |
9.20e-05 |
|
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).
Pssm-ID: 396154 [Multi-domain] Cd Length: 52 Bit Score: 41.92 E-value: 9.20e-05
10 20 30 40
....*....|....*....|....*....|....*....|
gi 2043825702 1094 NCSvGHTDCSRCQTADSkYNCVWCGGDNpSCIFRGSCKEE 1133
Cdd:pfam01437 1 RCS-QYTSCSSCLAARD-PYCGWCSSEG-RCVRRSACGAP 37
|
|
| PSI |
smart00423 |
domain found in Plexins, Semaphorins and Integrins; |
1094-1139 |
9.45e-05 |
|
domain found in Plexins, Semaphorins and Integrins;
Pssm-ID: 214655 [Multi-domain] Cd Length: 47 Bit Score: 41.76 E-value: 9.45e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1094 NCSVgHTDCSRCQTADSKYnCVWCGGDNpSCIFRGSCKEEVEDL----CP 1139
Cdd:smart00423 1 RCSK-YTSCSECLLARDPY-CAWCSSQG-RCTSGERCDSRRQNWlsggCP 47
|
|
| PSI |
smart00423 |
domain found in Plexins, Semaphorins and Integrins; |
650-677 |
4.94e-03 |
|
domain found in Plexins, Semaphorins and Integrins;
Pssm-ID: 214655 [Multi-domain] Cd Length: 47 Bit Score: 36.75 E-value: 4.94e-03
10 20
....*....|....*....|....*....
gi 2043825702 650 CQKCVSSLWG-CNWCIQQHLCTHKAACEE 677
Cdd:smart00423 8 CSECLLARDPyCAWCSSQGRCTSGERCDS 36
|
|
| PSI |
pfam01437 |
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ... |
650-675 |
8.28e-03 |
|
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).
Pssm-ID: 396154 [Multi-domain] Cd Length: 52 Bit Score: 36.53 E-value: 8.28e-03
10 20
....*....|....*....|....*..
gi 2043825702 650 CQKCVSSL-WGCNWCIQQHLCTHKAAC 675
Cdd:pfam01437 8 CSSCLAARdPYCGWCSSEGRCVRRSAC 34
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Sema_plexin_B1 |
cd11275 |
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ... |
27-489 |
0e+00 |
|
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200536 [Multi-domain] Cd Length: 461 Bit Score: 942.85 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 27 FSHNATKFLHLSMDLESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHHTDNHNKLLLVNPVQ 106
Cdd:cd11275 1 FSPNGTKFLHLSMDPESGTLYLGATNFLFQLTPDLLLENMVQTGPVLDSKDCLPPVSKLECPQAQHTNNHNKLLLVNPVQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 107 KELIVCGSVHQGICEKRSLASIDHVLFRPESPGDTQYVAANDPNITTVGLIAYSKDEVPLLFVGRGYTSRGVGGGIPPIT 186
Cdd:cd11275 81 KELIVCGSVHQGICEKRRLGSIDHVLFRPERPGDTQYVAANDPNVTTVGLVAYSKDGVPLLFVGRGYTSRGVGGGIPPIT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 187 TRNLRAHGGDvqATDSHSIFSYEETAKLAVGRLSEYNHHFIKSFTYHSSVYFLFYRRDLKSQSREYKTYISRICLDDSHY 266
Cdd:cd11275 161 TRNLRAHGDD--ATDSHSIFSYEETAKLAVGRLSEYNHHFIKAFTYGSSVYFLFYRRDLKSQSREYKTYISRICLDDSHY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 267 YSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQGQLDTEGEVLFAAFSAWQASSGKLSEESALCVYTMEEVDRLTNWTR 346
Cdd:cd11275 239 YSYVELPLLCQSKANTYSLLQAAYVTQPGERLAQGQLDTDGEVLFAAFSAWQASSGKLSEESALCAYPMDEVDRLTNWTR 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 347 DVCYMRDGKSEEGTEVAYIEYDVSSNCVQLPADTLYAYPCGSDHTPSPMASRVPLEAAPLLEKTEARLTAVAVNVEDGHT 426
Cdd:cd11275 319 DVCYTRDGKAEDGTEVAYIEYDVSSNCVQLPADTLDAYPCGSDHTPSPMASRVPLEATPLLEWTEIRLTAVAVNVEDGHT 398
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2043825702 427 IAFLGDSRGRLHKVYLGAQGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPIM 489
Cdd:cd11275 399 IAFLGDSRGRLHKVYLGAGGDAHTYSSQSIQQNSAVSGDLLFDQLQEHLYVMTQSTVLKVPIA 461
|
|
| Plexin_cytopl |
pfam08337 |
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ... |
1632-2168 |
0e+00 |
|
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.
Pssm-ID: 462434 [Multi-domain] Cd Length: 500 Bit Score: 894.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1632 GIPFLDYKSYAERIFFPGHRESPLQRDLDIP---ECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVA 1708
Cdd:pfam08337 1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPvtnDGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1709 SLLTVSLHGKLEYFTDILKTLLNDLVEQYV-AKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQ 1787
Cdd:pfam08337 81 SLLMVALHGKLEYATEILKTLLRDLIDKSVeSKNPKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1788 VDKGPVDWVTGKAKYTLNDNRLLREDLEYRTLTLNALTQAGvgaggaEDSQGISAKVLDCDTITQVKEKILDQIYKGTPY 1867
Cdd:pfam08337 161 VEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEG------ENSESVPVKVLDCDTITQVKEKILDAIYKNTPY 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1868 CHRPDPDTLDLEWRSGLAGHLILSDEDVTSVVQGTWKRLNTLQHYKVPDGATVALVPrltkhihrenqdyipgektpmle 1947
Cdd:pfam08337 235 SQRPSIDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP----------------------- 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1948 dadeggiKLWHLVKPTEEPELPKHrrgslrDRERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST-NRPVPLAVKYFF 2026
Cdd:pfam08337 292 -------KYWHLVKPSDEGDQRKK------SERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVpNSALPLAVKYLF 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 2027 DLLDEQAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINK 2106
Cdd:pfam08337 359 DFLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEHRLGKDSPSNK 438
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2043825702 2107 LLYARDIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKYINK 2168
Cdd:pfam08337 439 LLYAKDIPRYKQMVERYYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
|
|
| RasGAP_plexin_B1 |
cd12793 |
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane ... |
1632-2205 |
0e+00 |
|
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D and plexin-B1 signaling complex regulates dendritic and axonal complexity. The activation of Plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin-B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin-B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin-B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213353 [Multi-domain] Cd Length: 394 Bit Score: 797.70 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1632 GIPFLDYKSYAERIFFPGHRESPLQRDLDIPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVASLL 1711
Cdd:cd12793 1 GIPFLDYRMYAERIFFPGHRESPLRRDLDVPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLESQRTFSPRDRAYVASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1712 TVSLHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQVDKG 1791
Cdd:cd12793 81 TVALHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFLRDSAGESLYMLFRAIKHQVDKG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1792 PVDWVTGKakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtitqvkekildqiykgtpychrp 1871
Cdd:cd12793 161 PVDAVTGK------------------------------------------------------------------------ 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1872 dpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpmledade 1951
Cdd:cd12793 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1952 ggiklwhlvkpteepelpkhrrgslrdrERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTNRPVPLAVKYFFDLLDE 2031
Cdd:cd12793 169 ----------------------------ERAKAIPEIYLTRLLSMKGTLQKFVDDLFTVILSTSRPVPLAVKYFFDLLDE 220
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 2032 QAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINKLLYAR 2111
Cdd:cd12793 221 QALQHGISDPETIHIWKTNSLPLRFWINIIKNPQFIFDVQTSDNVDAVLSVIAQTFMDSCTIADHKLGRDSPINKLLYAR 300
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 2112 DIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKYINKYYDQIITALEEDPTAQKMQLGYR 2191
Cdd:cd12793 301 DIPRYKQMVERYYADIRQTVSASDQEMNSALAELSRNYSGELNYLVALHELYKYINKYYDQIITALEEDSTAQKMQLGYR 380
|
570
....*....|....
gi 2043825702 2192 LQQIAAAVENKVTD 2205
Cdd:cd12793 381 LQQIAAAVENKVTD 394
|
|
| RasGAP_plexin_B |
cd12787 |
Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of ... |
1632-2201 |
0e+00 |
|
Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity.There are three members of the Plexin-B subfamily, namely B1, B2 and B3. Plexins-B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin-B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin-B signaling. Plexin-B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin-B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213347 [Multi-domain] Cd Length: 391 Bit Score: 720.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1632 GIPFLDYKSYAERIFFPGHRESPLQRD--LDIPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVAS 1709
Cdd:cd12787 1 GIPFLDYKTYAERVFFPGHKDGPLDVMikLDIPEPRRPTVEQGLYQLSNLLNSKLFLINFIHTLENQREFSARDRVYVAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1710 LLTVSLHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQVD 1789
Cdd:cd12787 81 LLTVALHGKLEYYTDIMRTLLLDLLAQYVVKNPKLMLRRTETVVEKLLTNWMSICLYQFLRDSAGEPLYMLFRAIKHQVD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1790 KGPVDWVTGKakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtitqvkekildqiykgtpych 1869
Cdd:cd12787 161 KGPVDAVTGK---------------------------------------------------------------------- 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1870 rpdpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpmleda 1949
Cdd:cd12787 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1950 deggiklwhlvkpteepelpkhrrgslrdreRAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTNRPVPLAVKYFFDLL 2029
Cdd:cd12787 171 -------------------------------RAKAIPEIYLTRLLSMKGTLQKFVDDFFQSILSPGRPVPPAVKYFFDLL 219
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 2030 DEQAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINKLLY 2109
Cdd:cd12787 220 DEQAEKHGIQDEDTIHIWKTNSLPLRFWVNILKNPQFIFDVHVSDNVDASLSVIAQTFMDACTRTEHKLGRDSPSNKLLY 299
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 2110 ARDIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKYINKYYDQIITALEEDPTAQKMQLG 2189
Cdd:cd12787 300 AREIPRYKKMVERYYADIRQMVPASDQEMNSHLAELSRNYTDSLNTLVALHELYQYIQKYYDQIINALEEDPAAQKMQLA 379
|
570
....*....|..
gi 2043825702 2190 YRLQQIAAAVEN 2201
Cdd:cd12787 380 FRLQQIAAAVEN 391
|
|
| RasGAP_plexin_B3 |
cd12791 |
Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane ... |
1632-2205 |
0e+00 |
|
Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin-B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The protein and mRNA expression of Sema5A and its receptor plexin-B3 increased gradually in non-neoplastic mucosa, primary gastric carcinoma, and lymph node metastasis, and their expression is correlated. The stimulation of plexin-B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213351 [Multi-domain] Cd Length: 397 Bit Score: 688.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1632 GIPFLDYKSYAERIFFPGHRESPLQR--DLDIPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVAS 1709
Cdd:cd12791 1 GIPFLDYRTYAERVFFPGHGGCPLQPslEGDGEEGRRATVEQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1710 LLTVSLHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQVD 1789
Cdd:cd12791 81 LLSLALHGKLEYLTDIMKTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWMSICLYAFLREVAGEPLYMLFRAIKYQVD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1790 KGPVDWVTGKakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtitqvkekildqiykgtpych 1869
Cdd:cd12791 161 KGPVDAVTGK---------------------------------------------------------------------- 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1870 rpdpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpmleda 1949
Cdd:cd12791 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1950 deggiklwhlvkpteepelpkhrrgslrdRERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTNRPVPLAVKYFFDLL 2029
Cdd:cd12791 171 -----------------------------RERAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSVNRPVPIAVKYLFDFL 221
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 2030 DEQAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINKLLY 2109
Cdd:cd12791 222 DELAEKHGIEDPETLHIWKTNSLLLRFWVNTLKNPQFIFDVRVSDNVDAILAVIAQTFIDSCTISEHKVGRDSPVNKLLY 301
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 2110 ARDIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKYINKYYDQIITALEEDPTAQKMQLG 2189
Cdd:cd12791 302 AREIPRYKQMVEKYYADIRQSSPASYQEMNSALTELSGNYTSAPHCLVALQELYNHIHRYYDQIISALEEDPVGQKMQLA 381
|
570
....*....|....*.
gi 2043825702 2190 YRLQQIAAAVENKVTD 2205
Cdd:cd12791 382 CRLQQIAALVENKVTD 397
|
|
| Sema_plexin_B |
cd11245 |
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin ... |
34-488 |
0e+00 |
|
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin domains, function as receptors of semaphorins and may be the ancestors of semaphorins. There are three members of the Plexin B subfamily, namely B1, B2 and B3. Plexins B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin B signaling. Plexin B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200506 [Multi-domain] Cd Length: 440 Bit Score: 584.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 34 FLHLSMDLESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHHTDNHNKLLLVNPVQKELIVCG 113
Cdd:cd11245 2 INHLAQDPQTGRLYLGAVNGLFQLSPNLQLESRADTGPKKDSPQCLPPITAAECPQAKETDNFNKLLLVNSANGTLVVCG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 114 SVHQGICEKRSLASIDHVLFRPESPGDTQYVAANDPNITTVGLIAYSKDEVPLLFVGRGYTSRGvGGGIPPITTRNLRAH 193
Cdd:cd11245 82 SLFQGVCELRNLNSVNKPLYRPETPGDKQYVAANEPSVSTVGLISYFKDGLSLLFVGRGYTSSL-SGGIPPITTRLLQEH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 194 ggdvqatDSHSIFSYEETAKLAVGRLSEYNHHFIKSFTYHSSVYFLFYRRDLKSQsREYKTYISRICLDDSHYYSYVELP 273
Cdd:cd11245 161 -------GEMDAFSNEVEAKLVVGSASRYHHDFVYAFADNGYIYFLFSRRPGTAD-STKRTYISRLCENDHHYYSYVELP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 274 LLCQ-SKANTYSLLQAAYVTRPGKELaqgqldtEGEVLFAAFSAWQASSGKLSEESALCVYTMEEVDRLTNWTRDVCYMR 352
Cdd:cd11245 233 LNCTvNQENTYNLVQAAYLAKPGKVL-------NGKVLFGVFSADEASTAAPDGRSALCMYPLSSVDARFERTRESCYTG 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 353 DGKSEEGTEVAYIEYDVSSNCVQLPADTLYAYPCGSDHTPSPMASRVPLEAAPLLEkTEARLTAVAVNVEDGHTIAFLGD 432
Cdd:cd11245 306 EGLEDDKPETAYIEYNVKSICKTLPDKNVKAYPCGAEHTPSPLASRYPLAAKPILT-RNDMLTAVAVAVENGHTIAFLGD 384
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 2043825702 433 SRGRLHKVYLGAqGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPI 488
Cdd:cd11245 385 SGGQLHKVYLDP-NHTDFYSTIPGDQDSAVNKDLLFDSTLNHLYVMTGKKISKVPV 439
|
|
| RasGAP_plexin_B2 |
cd12792 |
Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane ... |
1632-2205 |
0e+00 |
|
Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Mice lacking Plexin-B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C and Plexin-B2 signaling modulates ureteric branching. Plexin-B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin-B2 results in renal hypoplasia and occasional double ureters. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213352 [Multi-domain] Cd Length: 400 Bit Score: 559.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1632 GIPFLDYKSYAERIFF----PGHRESPLQRDLDIPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYV 1707
Cdd:cd12792 1 RIPFLDYKTYTDRVFFlpskDGANDVMITGKLDIPEARRATVEQALNQFSNLLNSKTFLINFIHTLENQRDFNARAKVYF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1708 ASLLTVSLHGKLEYFTDILKTLLNDLVEQYV-AKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKH 1786
Cdd:cd12792 81 ASLLTVALHGKLEYYTDIMRTLLLELMEQYVhSKNPKLMLRRSETVVERMLSNWMSICLYQYLKDTAGEPLYKLFKAIKH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1787 QVDKGPVDwvtgkakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtiTQVKEKildqiykgtp 1866
Cdd:cd12792 161 QVEKGPVD--------------------------------------------------------AVQKKK---------- 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1867 ychrpdpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpml 1946
Cdd:cd12792 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1947 edadeggiklwhlvkpteepelpkhrrgslrdrERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTNRPVPLAVKYFF 2026
Cdd:cd12792 175 ---------------------------------ERTKAITEIYLTRLLSVKGTLQQFVDNFFRSVLCSGAVVPPAVKYFF 221
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 2027 DLLDEQAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINK 2106
Cdd:cd12792 222 DFLDEQAEKHDIVDEETIHIWKTNSLPLRFWVNILKNPHFIFDVHVTEVVDASLSVIAQTFMDACTKTEHKLSRDSPSNK 301
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 2107 LLYARDIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKYINKYYDQIITALEEDPTAQKM 2186
Cdd:cd12792 302 LLYAKEISTYKKMVDDYYKGIRQMVPVSDQDMNTHLAEISRAHTDKLNTQVALHQLYQYASKYYDEIINSLEEDPAAQSK 381
|
570
....*....|....*....
gi 2043825702 2187 QLGYRLQQIAAAVENKVTD 2205
Cdd:cd12792 382 QLTLRLQQIAAALENKVTD 400
|
|
| RasGAP_plexin |
cd12205 |
Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane ... |
1632-2197 |
0e+00 |
|
Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes, including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Other proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213344 [Multi-domain] Cd Length: 382 Bit Score: 557.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1632 GIPFLDYKSYAERIFFPGHRESPLQRDLDIPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVASLL 1711
Cdd:cd12205 1 GIPFLDFREYIIRVLFPGVNDHPVLLSKFVHGSRRPDLEDALSQFEQLLCNKQFLLTFIRTLESQPKFSSRDKCNVASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1712 TVSLHGKLEYFTDILKTLLNDLVEQYVAK-NPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQVDK 1790
Cdd:cd12205 81 MVALQGKMEYATEILFDLLTDLIEKSVSKkHPKLMLRRTESVVEKLLTNWLSLCLYDYLKETAGEPLFLLYKALKQQIEK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1791 GPVDWVtgkakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtitqvkekildqiykgtpychr 1870
Cdd:cd12205 161 GPVDAI-------------------------------------------------------------------------- 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1871 pdpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpmledad 1950
Cdd:cd12205 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1951 eggiklwhlvkpteepelpkhrrgslrdreraKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTN-RPVPLAVKYFFDLL 2029
Cdd:cd12205 167 --------------------------------KLIPEIFLTRLLSTKGTLQKFVDDLFESILSVPqRSLPPAIKYLFDFL 214
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 2030 DEQAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINKLLY 2109
Cdd:cd12205 215 DEQARKHGISDPDVLHAWKTNSLPLRFWVNIIKNPDFVFDVNKTPTVDSCLSVIAQTFMDACSTSEHKLGKDSPSNKLLF 294
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 2110 ARDIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKYINKYYDQIITALEEDPTAQKMQLG 2189
Cdd:cd12205 295 AKDIPRYREMVANFYRDISNLPPVSDEEMNSYLAELSESHSGEFNTNVALSELYIYAVKYGDQLLEALEDDREARVQQLA 374
|
....*...
gi 2043825702 2190 YRLQQIAA 2197
Cdd:cd12205 375 DKLSQVAR 382
|
|
| Sema_plexin_B3 |
cd11277 |
The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of ... |
27-488 |
1.71e-165 |
|
The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The stimulation of plexin B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200538 [Multi-domain] Cd Length: 434 Bit Score: 515.51 E-value: 1.71e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 27 FSHNATKFLHLSMDLESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHHTDNHNKLLLVNPVQ 106
Cdd:cd11277 1 FSAPNATFNHLALDPGSGTLYVGAVNRLYQLSPDLQLLGEAVTGPVLDSPDCLPFRDPADCPQARLTDNANKLLLVSERA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 107 KELIVCGSVHQGICEKRSLASIDHVLFRPESPGDTQYVAANDPNITTVGLIAYSKDeVPLLFVGRGYTSRGvGGGIPPIT 186
Cdd:cd11277 81 GELVACGQVRQGVCEKRRLGNVAQVLYQAEDPGDGQFVAANDPGVATVGLVVEAPG-RDLLLVGRGLTGKL-SAGIPPLT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 187 TRNLRAhggdVQAtdshsiFSYEETAKLAVGRLSEYNHHFIKSFTYHSSVYFLFYRRDLKSQsREYKTYISRICLDDSHY 266
Cdd:cd11277 159 IRQLAG----AQA------FSSEGLGKLVVGDFSDYNNSYVGAFAHNGYVYFLFRRRGARAQ-AEYRTYVARVCLGDTNL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 267 YSYVELPLLCQskaNTYSLLQAAYVTRPGKElaqgqldtegevLFAAFSAWQASSGKLSEESALCVYTMEEVDRLTNWTR 346
Cdd:cd11277 228 YSYVEVPLVCQ---GGYNLAQAAYLAPGQGT------------LFVVFAAGQGSTPTPTDQTALCAYPLVELDSAMERAR 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 347 DVCYMRDGKSEEGTEVAYIEYDVSSNCVQLPADTLYAYPCGSDHTPSPMASRVPLEAAPLLeKTEARLTAVAVNVEDGHT 426
Cdd:cd11277 293 RLCYTAGGGGPNGKEEATIEYGVTSRCVNLPKDSPESYPCGDEHTPSPIASRQPLEAEPLL-TLTPPLTAVAALQEDGHT 371
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2043825702 427 IAFLGDSRGRLHKVYLGAQGeAHTYASVSI-QVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPI 488
Cdd:cd11277 372 IAFLGDTQGQLHKVFLNGSA-GQVYSSQPVgPPGSAVNPDLLLDATGSHLYVLTARQVTKVPV 433
|
|
| RasGAP_plexin_A |
cd12790 |
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of ... |
1632-2195 |
1.92e-161 |
|
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. They are divided into four types (A-D) according to sequence similarity. In vertebrates, there are four type A plexins (A1-A4) that serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin-D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 1 and class 6 semaphorins signal through type A plexins, which mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a and Plexin-A mediated axon repulsion. In their complex with Sema6s, type A plexins serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin-A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213350 [Multi-domain] Cd Length: 385 Bit Score: 501.95 E-value: 1.92e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1632 GIPFLDYKSYAERIFFPGHRESPLQRDLDIPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVASLL 1711
Cdd:cd12790 1 GIPFLDYRTYAMRVLFPGIEDHPVLRELEVERDRQENVEKGLRLFGQLLMNKTFLLTFIRTLESQRSFSMRDRGNVASLI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1712 TVSLHGKLEYFTDILKTLLNDLVEQYVAK--NPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQVD 1789
Cdd:cd12790 81 MVVLQSKMEYATDILKQLLADLIEKNLESknHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFMLFCAIKQQME 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1790 KGPVDWVtgkakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtitqvkekildqiykgtpych 1869
Cdd:cd12790 161 KGPIDAI------------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1870 rpdpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpmleda 1949
Cdd:cd12790 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1950 deggiklwhlvkpteepelpkhrrgslrdreraKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTNR---PVPLAVKYFF 2026
Cdd:cd12790 168 ---------------------------------KMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHrgsALPLAIKYMF 214
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 2027 DLLDEQAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINK 2106
Cdd:cd12790 215 DFLDEQADQHGITDPEVVHTWKSNCLPLRFWVNLIKNPQFVFDIHKSSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNK 294
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 2107 LLYARDIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKYINKYYDQIITALEEDPTAQKM 2186
Cdd:cd12790 295 LLYAKDIPNYKSWVERYYADIAKMPAISDQDMNAYLAEQSRLHLNEFNTLSALNELYSYVTKYKEEILTALEEDEFARKQ 374
|
....*....
gi 2043825702 2187 QLGYRLQQI 2195
Cdd:cd12790 375 RLAYKLEQV 383
|
|
| RasGAP_plexin_D1 |
cd12788 |
Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane ... |
1632-2203 |
9.72e-142 |
|
Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. The Plexin-D1 and Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213348 [Multi-domain] Cd Length: 419 Bit Score: 448.67 E-value: 9.72e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1632 GIPFLDYKSYAERIFFP-----------------------GHRES-PLQRDLDIPECRRQTVEQGLVQLSNLLNSKLFLT 1687
Cdd:cd12788 2 GIPFLEYKHFVTRTFFPkcsslyeeryvlpsqennsqgprQVPEThPLLQEWKIPESCRPNMEEGITLFSTLLNNKHFLV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1688 KFIHTLEIQRTFSPRDRAYVASLLTVSLHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYA 1767
Cdd:cd12788 82 TFVHALEQQKDFAVRDRCNLASLLTIALHGKLEYYTSIMKDLLVDLIDASASKNPKLMLRRTESVVEKMLTNWMSICMYS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1768 FVRDSVGEPLYMLFRGIKHQVDKGPVDwvtgkakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldc 1847
Cdd:cd12788 162 YLRETVGEPFFLLLCAIKQQINKGSID----------------------------------------------------- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1848 dtitqvkekildqiykgtpychrpdpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprlt 1927
Cdd:cd12788 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1928 khihrenqdyipgektpmledadegGIKlwhlvkpteepelpkhrrgslrdreraKAIPEIYLTRLLSMKGTLQKFVDDL 2007
Cdd:cd12788 189 -------------------------AIK---------------------------KVLPEIYLTRLLSTKGTLQKFLDDL 216
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 2008 FQVILST--NRPvPLAVKYFFDLLDEQAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQ 2085
Cdd:cd12788 217 FQAILSIpeDRP-PLAVKYFFDFLEEQAEKRGITDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKTDHMDACLSVIAQ 295
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 2086 TFMDSCTIADHKLGRDSPINKLLYARDIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKY 2165
Cdd:cd12788 296 AFIDACSISDLQLGKDSPTNKLLYAKEIPEYRKIVQRYYQQIQEMPPLSEQEMNAHLAEESRKYRNEFNTNVAMAEIYKY 375
|
570 580 590
....*....|....*....|....*....|....*...
gi 2043825702 2166 INKYYDQIITALEEDPTAQKMQLGYRLQQIAAAVENKV 2203
Cdd:cd12788 376 AKRYRAQIVSALESNPTARRTQLQHKFEQVIALMEDNI 413
|
|
| Sema_plexin_B2 |
cd11276 |
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ... |
31-488 |
2.96e-122 |
|
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200537 [Multi-domain] Cd Length: 449 Bit Score: 394.14 E-value: 2.96e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 31 ATKFLHLSMDLESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHHTDNHNKLLLVNPVQKELI 110
Cdd:cd11276 5 ATELNHLVVDPQTGRVYLGAVNALYQLDADLQLESRVETGPKKDNKKCTPPIEENQCTEAKMTDNYNKLLLLDSANKTLV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 111 VCGSVHQGICEKRSLASIDHVLFRPESPGDTQYVAANDPNITTVGLIAYSKDE-VPLLFVGRGYTSRGVGggiPPITTRN 189
Cdd:cd11276 85 VCGSLFKGICSLRNLSNISEVIYYSDTSGEKSFVASNDEGVSTVGLISSLKPGnDRVFFVGKGNGSNDNG---KIISTRL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 190 LrahggdvQATDSHSIF-SYEETAKLAVGRLSEYNHHFIKSFTYHSSVYFLFyRRDLKSQSREYkTYISRICLDDSHYYS 268
Cdd:cd11276 162 L-------QNYDDREVFeNYIDAATVKSAYVSRYTQQFRYAFEDNNYVYFLF-NQQLGHPDKNR-TLIARLCENDHHYYS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 269 YVELPLLCQSKANTYSLLQAAYVTRPGKELAQ--GQLDTEGEVLFAAFSAWQASSGklseESALCVYTMEEVDRLTNWTR 346
Cdd:cd11276 233 YTEMDLNCRDGANAYNKCQAAYVSTPGKELAQnyGNSILSDKVLFAVFSRDEKDSG----ESALCMFPLKSINAKMEANR 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 347 DVCYMrdgKSEEGTEVAYIEYDVSSN--CVQLPADTLYAYPCGSDHTPSPMASRVPL-EAAPLLEKTEARLTAVAVNVED 423
Cdd:cd11276 309 EACYT---GTIDDRDVFYKPFHSQKDiiCGSHQQKNSKSFPCGSEHLPYPLGSRDELaLTAPVLQRGGLNLTAVTVAVEN 385
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2043825702 424 GHTIAFLGDSRGRLHKVYLGAQGEAhtYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPI 488
Cdd:cd11276 386 GHTVAFLGTSDGRILKVHLSPDPEE--YNSILIEKNKPVNKDLVLDKTLEHLYIMTEDKVFRLPV 448
|
|
| RasGAP_plexin_C1 |
cd12789 |
Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane ... |
1629-2202 |
1.95e-115 |
|
Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-C1 has been identified as the receptor of semaphorin 7A, which plays regulatory roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin-C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin-C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A and Plexin-C1 signaling. Melanoma invasion and metastasis may be promoted through the loss of Plexin-C1 inhibitory signaling on cofilin activation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213349 [Multi-domain] Cd Length: 393 Bit Score: 372.27 E-value: 1.95e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1629 VGTgIPFLDYKSYAERIFFPGHRESPLQRDLDIPECRRQT-VEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYV 1707
Cdd:cd12789 1 FGT-VPFLDYKHFALRTFFPESGGFTHIFTRDDPHDRDQTdKDESLTALDKLICNKSFLVTLIHTLEKQKNFSVKDRCLF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1708 ASLLTVSLHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQ 1787
Cdd:cd12789 80 ASFLTIALQTKLVYLTEILEVLTKDLMDQSSNAQPKLLLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1788 VDKGPVDWVTGKAKytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtitqvkekildqiykgtpy 1867
Cdd:cd12789 160 INKGPVDVIKFKVK------------------------------------------------------------------ 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1868 chrpdpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpmle 1947
Cdd:cd12789 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1948 dadeggiklwhlvkpteepelpkhrrgslrdrerakaipEIYLTRLLSMKGTLQKFVDDLFQVI--LSTNRPvPLAVKYF 2025
Cdd:cd12789 174 ---------------------------------------EMYLTKLLSTKVAIHSVVEKLFRSIwsLPNNKA-PVAIKYF 213
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 2026 FDLLDEQAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPIN 2105
Cdd:cd12789 214 FDFLDAQAENKKITDPDVLHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHLDGCLSVIAQAFMDSFSLSEQHLGKEAPTN 293
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 2106 KLLYARDIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKYINKYYDQIITALEEDPTAQK 2185
Cdd:cd12789 294 KLLYAKDIPQYKEEVKSYYKAIRDLPPLSSSELEEFLTQESKKHENEFNEEVALMEIYKYIVKYFDEILNKLERERGLEE 373
|
570
....*....|....*..
gi 2043825702 2186 MQlgYRLQQIAAAVENK 2202
Cdd:cd12789 374 VQ--KQLLHVKALFDEK 388
|
|
| Sema_plexin_like |
cd11236 |
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine ... |
34-488 |
2.12e-115 |
|
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestor of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signalling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. This family also includes the Met and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200497 [Multi-domain] Cd Length: 401 Bit Score: 372.43 E-value: 2.12e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 34 FLHLSMDLESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHHTDNHNKLLLVNPVQKELIVCG 113
Cdd:cd11236 2 FNHLAVDNSTGRVYVGAVNRLYQLDSSLLLEAEVSTGPVLDSPLCLPPGCCSCDHPRSPTDNYNKILLIDYSSGRLITCG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 114 SVHQGICEKRSLASIDHVLFRpespgDTQYVAANDPNITTVGLIAYSKD-EVPLLFVGRGYTSRGVGGGIPPITTRNLRa 192
Cdd:cd11236 82 SLYQGVCQLRNLSNISVVVER-----SSTPVAANDPNASTVGFVGPGPYnNENVLYVGATYTNNGYRDYRPAVSSRSLP- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 193 hggdvqATDSHSIFSYEETAKLAVGRLS--EYNHHFIKSFTYHSSVYFLFYRRDLKSQSREYKTYISRICLDDSHYYSYV 270
Cdd:cd11236 156 ------PDDDFNAGSLTGGSAISIDDEYrdRYSIKYVYGFSSGGFSYFVTVQRKSVDDESPYISRLVRVCQSDSNYYSYT 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 271 ELPLLCQSKANT-YSLLQAAYVTRPGKELAQG-QLDTEGEVLFAAFSAWQASSGKLSEESALCVYTMEEVDRltnwtrdv 348
Cdd:cd11236 230 EVPLQCTGGDGTnYNLLQAAYVGKAGSDLARSlGISTDDDVLFGVFSKSKGPSAEPSSKSALCVFSMKDIEA-------- 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 349 cymrdgkseegtevAYIEYdvssncvqlpadtlyaypcgsdhtpSPMASRVPLEAAPLLEktEARLTAVAVNVEDGHTIA 428
Cdd:cd11236 302 --------------AFNDN-------------------------CPLGGGVPITTSAVLS--DSLLTSVAVTTTRNHTVA 340
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 429 FLGDSRGRLHKVYLGAQGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPI 488
Cdd:cd11236 341 FLGTSDGQLKKVVLESSSSATQYETLLVDSGSPILPDMVFDPDGEHLYVMTPKKVTKVPV 400
|
|
| Sema |
smart00630 |
semaphorin domain; |
34-456 |
9.26e-69 |
|
semaphorin domain;
Pssm-ID: 214747 [Multi-domain] Cd Length: 390 Bit Score: 237.65 E-value: 9.26e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 34 FLHLSMDLESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKlecPQAHHTDNHNKL-LLVNPVQKELIVC 112
Cdd:smart00630 1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECVSK---GKDPPTDCVNYIrLLLDYNEDRLLVC 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 113 GS-VHQGICEKRSLasidhvlfrpespgdtqyvaandpnittvgliayskdevPLLFVGRGYTSRGVGGGIPP-ITTRNL 190
Cdd:smart00630 78 GTnAFQPVCRLRNL---------------------------------------GELYVGTVADFSGSDPAIPRsLSVRRL 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 191 RAHGGDVQATDSHSIFSYeetaklavgrlseYNHHFIKSFTYHSSVYFLFYRR--DLKSQSREYKTYISRICLDD----- 263
Cdd:smart00630 119 KGTSGVSLRTVLYDSKWL-------------NEPNFVYAFESGDFVYFFFRETavEDDNCGKAVHSRVARVCKNDvggpr 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 264 ---SHYYSYVELPLLCQSKANT---YSLLQAAYVTRPGKElaqgqldtEGEVLFAAFSAWQASSGKlseeSALCVYTMEE 337
Cdd:smart00630 186 sldKKWTSFLKARLECSVPGEDpfyFNELQAAFLLPPGSE--------SDDVLYGVFSTSSNPIPG----SAVCAFSLSD 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 338 VDRLTNWTRDVCYMRDGKSEEGTEvAYIEYDVSSNCVQLPADTLyAYPC----GSDHTPSPMASRVPLEAAPLLEKT--E 411
Cdd:smart00630 254 INAVFNGPFKECETSTSQWLPYSR-GKVPYPRPGTCPNKPPSSK-DLPDetlnFIKSHPLMDEVVQPLTGRPLFVKTdsN 331
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 2043825702 412 ARLTAVAVNVED---GHTIAFLGDSRGRLHKVYL---GAQGEAHTYASVSI 456
Cdd:smart00630 332 YLLTSIAVDRVAtdgNYTVLFLGTSDGRILKVVLsesSSSSESVVLEEISV 382
|
|
| Sema_plexin_A2 |
cd11272 |
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor ... |
24-526 |
1.88e-67 |
|
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200533 [Multi-domain] Cd Length: 515 Bit Score: 238.29 E-value: 1.88e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 24 YVTF--SHNATKFLHLSMDLESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHH-TDNHNKLL 100
Cdd:cd11272 1 FNTFhsENRDWTFNHLTVHQSTGAVYVGAINRVYKLSGNLTILVAHKTGPEEDNKSCYPPLIVQPCSEVLTlTNNVNKLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 101 LVNPVQKELIVCGSVHQGICEKRSLASIdHVLFRPeSPGDTQYVAANDPNITTVGLIAYSKDEVPLLFVGRGytsrgVGG 180
Cdd:cd11272 81 IIDYSENRLLACGSLYQGVCKLLRLDDL-FILVEP-SHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTA-----VDG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 181 G---IPPITTRNLRahggdvQATDSHSIFSYEETAKL----------AVGRLSEYNHHFIKSFTYHSSVYFLFYRRDL-- 245
Cdd:cd11272 154 KqdyFPTLSSRKLP------RDPESSAMLDYELHSDFvsslikipsdTLALVSHFDIFYIYGFASGNFVYFLTVQPETpe 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 246 -----KSQSREYKTYISRICLDDSHYYSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQG-QLDTEGEVLFAAFSAWQA 319
Cdd:cd11272 228 gvsinSAGDLFYTSRIVRLCKDDPKFHSYVSLPFGCVRGGVEYRLLQAAYLSKPGEVLARSlNITAQEDVLFAIFSKGQK 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 320 SSGKLSEESALCVYTMEEVDRLTNWTRDVCYMRDGKSEEGTevaYIEYDVSSNCVQLPADTLYaypCGSDhTPSPMASRV 399
Cdd:cd11272 308 QYHHPPDDSALCAFPIRAINAQIKERLQSCYQGEGNLELNW---LLGKDVQCTKAPVPIDDNF---CGLD-INQPLGGST 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 400 PLEAAPLLEKTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYlgAQGEAH---TYASVSI-QVNSMVSGDLLFDQLQEHL 475
Cdd:cd11272 381 PVEGVTLYTSSRDRLTSVASYVYNGYSVVFVGTKSGKLKKIR--ADGPPHggvQYEMVSVfKDGSPILRDMAFSIDHKYL 458
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 2043825702 476 FVMTQSMVVKVPIMECSLYLDCESCLALKDPYCGWCVLQGRCSRRSECLRS 526
Cdd:cd11272 459 YVMSERQVSRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQRA 509
|
|
| Sema_plexin_A |
cd11244 |
The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of ... |
24-488 |
1.07e-60 |
|
The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of semaphorins and may be the ancestor of semaphorins. Members of the Plexin A subfamily are receptors for Sema1s, Sema3s, and Sema6s, and they mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a-Plexin A mediated axon repulsion. Sema3s do not interact directly with plexin A receptors, but instead bind Neuropilin-1 or Neuropilin-2 toactivate neuropilin-plexin A holoreceptor complexes. In contrast to Sema3s, Sema6s do not require neuropilins for plexin A binding. In the complex, plexin As serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200505 [Multi-domain] Cd Length: 470 Bit Score: 217.00 E-value: 1.07e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 24 YVTFS--HNATKFLHLSMDLESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQA-HHTDNHNKLL 100
Cdd:cd11244 1 FVTFRgePRDWSFNHLTVHRRTGEVYVGAINRVYKLSSNLTVLVTHETGPVEDNPKCYPPPIVQTCNEPlTTTNNVNKLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 101 LVNPVQKELIVCGSVHQGICEKRSLASidhvLFRPESPGDTQ--YVAANDPNITTVGLIAYSKDEVPLLFVGRGYTsrGV 178
Cdd:cd11244 81 LIDYSENRLIACGSLYQGVCKLLRLED----LFKLGEPHHKKehYLSGVNESGTMFGVIVSYSNGDDKLFIGTAVD--GK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 179 GGGIPPITTRNLRAHggdvqaTDSHSIFSYE-------ETAKLAVGRLSEYNH---HFIKSFTYHSSVYFLFYRRDLKSQ 248
Cdd:cd11244 155 SEYFPTLSSRKLTAD------EESDGMFAYVyhdefvsSQIKIPSDTLSIIPDfdiYYVYGFSSGNFVYFLTLQPETQLT 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 249 SRE------YKTYISRICLDDSHYYSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQG-QLDTEGEVLFAAFSAWQASS 321
Cdd:cd11244 229 PGDstgeqfYTSKIVRLCKDDTKFYSYVEFPIGCTRDGVEYRLLQAAYLSKPGKALAQAlGISEDEDVLFTIFSKGQKNR 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 322 GKLSEESALCVYTMEEVDRLTNWTRDVCYMRDGKseegTEVAYI-EYDVSSNCVQLPADTLYaypCGSDHTpSPMASRVP 400
Cdd:cd11244 309 MKPPDESALCLFTLKQINLRIKERLQSCYRGEGK----LSLPWLlNKDLPCINAPLQIDDNF---CGLDMN-QPLGGSDM 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 401 LEAAPLLEKTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYL-GAQGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMT 479
Cdd:cd11244 381 VEGIPLFTDDRDRMTSVAAYVYKGHSVVFVGTKSGKLKKIRVdGPPHNALQYETVQVVEGSPILRDMAFSPDHQYLYIMS 460
|
....*....
gi 2043825702 480 QSMVVKVPI 488
Cdd:cd11244 461 ERQVTRVPV 469
|
|
| Plexin_RBD |
pfam20170 |
Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding ... |
1804-1922 |
5.04e-57 |
|
Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding domain found in the cytoplasmic domain of plexins.
Pssm-ID: 466321 Cd Length: 113 Bit Score: 193.18 E-value: 5.04e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1804 LNDNRLLREDLEYRTLTLNALTQAGvgaggaEDSQGISAKVLDCDTITQVKEKILDQIYKGTPYCHRPDPDTLDLEWRSG 1883
Cdd:pfam20170 1 LSEDKLLREQIDYKTLTLNVIFEEG------EVSESVPVKVLDCDTISQVKEKILDAVYKNTPYSQRPSIDDVDLEWRHG 74
|
90 100 110
....*....|....*....|....*....|....*....
gi 2043825702 1884 LAGHLILSDEDVTSVVQGTWKRLNTLQHYKVPDGATVAL 1922
Cdd:pfam20170 75 RGGRLILQDEDSTSKVEGGWKKLNTLAHYKVPDGATLAL 113
|
|
| Sema_plexin_A1 |
cd11271 |
The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the ... |
26-488 |
3.82e-55 |
|
The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the nervous and immune systems. Its external Sema domain is also shared by semaphorin proteins. In the nervous system, Plexin A1 mediates Sema3A axon guidance function by interacting with the Sema3A coreceptor neuropilin, resulting in actin depolarization and cell repulsion. In the immune system, Plexin A1 mediates Sema6D signaling by binding to the Sema6D-Trem2-DAP12 complex on immune cells and osteoclasts to promote Rac activation and DAP12 phosphorylation. In gene profiling experiments, Plexin A1 was identified as a CIITA (class II transactivator) regulated gene in primary dendritic cells (DCs). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200532 [Multi-domain] Cd Length: 474 Bit Score: 200.96 E-value: 3.82e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 26 TFSHNATKFLHLSMDLESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQA-HHTDNHNKLLLVNP 104
Cdd:cd11271 6 TFTASDWSLTHLVVHNKTGEVYVGAVNRIYKLSNNLTLLRTHVTGPVEDNEKCYPPPSVQSCPHGlGTTNNVNKLLLVDY 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 105 VQKELIVCGSVHQGICEKRSLASidhvLFRPESPGDTQ--YVAANDPNITTVGLIAYSKDEVPLLFVGRGYTsrGVGGGI 182
Cdd:cd11271 86 AANRLIACGSASQGICQFLRLDD----LFKLGEPHHRKehYLSSVNESGTMSGVIIEVGNGQNKLFVGTPID--GKSEYF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 183 PPITTRNLRAHGGDVQATDshsiFSYEE---TAKLAV-----GRLSEYNHHFIKSFTYHSSVYFLFYRRDLKSQSRE--- 251
Cdd:cd11271 160 PTLSSRKLMANEENAEMFG----FVYQDefvSSQLKIpsdtlSKFPTFDIYYVYSFSSEQFVYYLTLQLDTQLTSPDstg 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 252 ---YKTYISRICLDDSHYYSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQGQLDTEGE-VLFAAFSAWQASSGKLSEE 327
Cdd:cd11271 236 eqfFTSKIVRLCVDDPKFYSYVEFPIGCEQDGVEYRLIQDAYLSKPGKALAKQLGISEREdILFTVFSQGQKNRVKPPKE 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 328 SALCVYTMEEVDRLTNWTRDVCYMRDGKseegTEVAYIeYDVSSNCVQLPADTLYAYpCGSDHTpSPMASRVPLEAAPLL 407
Cdd:cd11271 316 SVLCLFTLKKIKDKIKERIQSCYRGEGK----LSLPWL-LNKELGCINSPLQIDDNF-CGQDFN-QPLGGTVTIEGTPLF 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 408 EKTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYLGAQGE----AHTYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMV 483
Cdd:cd11271 389 VDKEDGMTSVAAYDYRGRTVVFAGTRSGRIKKILVDLSAPssrpALQYENVVAHEGSPILRDLVLSPDRQYIYAMTEKQV 468
|
....*
gi 2043825702 484 VKVPI 488
Cdd:cd11271 469 TRVPV 473
|
|
| Sema_plexin_A4 |
cd11274 |
The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor ... |
24-492 |
1.52e-54 |
|
The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor complex with neuropilins (NRPs) and transduces signals for class 3 semaphorins in the nervous system. It regulates facial nerve development by functioning as a receptor for Sema3A/NRP1. Both plexins A3 and A4 are essential for normal sympathetic development. They function both cooperatively, to regulate the migration of sympathetic neurons, and differentially, to guide sympathetic axons. Plexin A4 is also expressed in lymphoid tissues and functions in the immune system. It negatively regulates T lymphocyte responses. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200535 [Multi-domain] Cd Length: 473 Bit Score: 199.02 E-value: 1.52e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 24 YVTF--SHNATKFLHLSMDLESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLEC-PQAHHTDNHNKLL 100
Cdd:cd11274 1 FITFtgDQTEWTFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQTCnEPLTLTNNINKML 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 101 LVNPVQKELIVCGSVHQGICEkrsLASIDHvLFRPESPGDTQ--YVAANDPNITTVGLIAYSKDEVPLLFVGRGYTsrGV 178
Cdd:cd11274 81 LIDYKENRLIACGSLYQGICK---LLRLDD-LFKLGEPFHKKehYLSGVNESGSVFGVIVSYSNLDDKLFIATAVD--GK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 179 GGGIPPITTRNLrahggdVQATDSHSIFSY----EETAKL------AVGRLSEYNHHFIKSFTYHSSVYFLFYRRDL--- 245
Cdd:cd11274 155 PEYFPTISSRKL------TKNSEADGMFAYvfhdEFVASMikipsdTFTIIPDFDIYYIYGFSSGNFVYFLTLQPEMisp 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 246 -KSQSRE--YKTYISRICLDDSHYYSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQG-QLDTEGEVLFAAFSAWQASS 321
Cdd:cd11274 229 pGSTTKEqvYTSKLVRLCKEDTAFNSYVEVPIGCEKNGVEYRLLQAAYLSKAGAILARSlGVGPDDDILFTVFSKGQKRK 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 322 GKLSEESALCVYTMEEVDRLTNWTRDVCYmrdgKSEEGTEVAYIEY-DVSSNCVQLPADTLYaypCGSDHTpSPMASRVP 400
Cdd:cd11274 309 MKSLDESALCIFVLKEINDRIKDRLQSCY----RGEGTLDLAWLKVkDIPCSSALLTIDDNF---CGLDMN-APLGVSEM 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 401 LEAAPLLEKTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYL-GAQGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMT 479
Cdd:cd11274 381 VRGLPVFTEDRDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVdGTTKNALQYETVQVVDTGPILRDMAFSKDHEQLYIMS 460
|
490
....*....|...
gi 2043825702 480 QSMVVKVPIMECS 492
Cdd:cd11274 461 EKQLTRVPVESCG 473
|
|
| Sema_plexin_A3 |
cd11273 |
The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor ... |
26-488 |
5.52e-54 |
|
The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor complex with neuropilin-2 and transduces signals for class 3 semaphorins in the nervous system. Both plexins A3 and A4 are essential for normal sympathetic neuron development. They function cooperatively to regulate the migration of sympathetic neurons, and differentially to guide sympathetic axons. Both plexins A3 and A4 are not required for guiding neural crest precursors prior to reaching the sympathetic anlagen. Plexin A3 is a major driving force for intraspinal motor growth cone guidance. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200534 [Multi-domain] Cd Length: 469 Bit Score: 197.46 E-value: 5.52e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 26 TFSHNATKFLHLSMDLESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQA-HHTDNHNKLLLVNP 104
Cdd:cd11273 5 AFVVTDTTLTHLAVHRVTGEVFVGAVNRVYKLSANLTELRAHVTGPVEDNARCYPPPSVRVCAHRlAPVDNVNKLLLVDY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 105 VQKELIVCGSVHQGICEKRSLASIDHvLFRPESPGDTQYVAANDPNiTTVGLIAYSKDEVPLLFVGRGytsrgVGGG--- 181
Cdd:cd11273 85 AGNRLVACGSIWQGVCQFLRLEDLFK-LGEPHHRKEHYLSGAQEPD-SMAGVIVEQGKGPSKLFVGTA-----IDGKsey 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 182 IPPITTRNLRAhggDVQATDSHSIFSYEE----TAKLAVGRLSEY---NHHFIKSFTYHSSVYFLFYRRDLK------SQ 248
Cdd:cd11273 158 FPTLSSRKLIS---DEDSADMFSLVYQDEfvssQIKIPSDTLSLYpafDIYYVYGFVSASFVYFLTLQLDTQqtlldtAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 249 SREYKTYISRICLDDSHYYSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQGQLDTEGE-VLFAAFSAWQASSGKLSEE 327
Cdd:cd11273 235 EKFFTSKIVRMCANDTEFYSYVEFPLGCSKDGVEYRLVQAAHLAKPGLLLAQALGVPEDEdVLFTIFSQGQKNRASPPRE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 328 SALCVYTMEEVDRLTNWTRDVCYMRDGKseegtevayieydvssncVQLPADTLYAYPCgsDHTP-------------SP 394
Cdd:cd11273 315 TILCLFTLSNINAHIRERIQSCYRGEGT------------------LSLPWLLNKELPC--INTPmqingnfcglvlnQP 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 395 MASRVPLEAAPLLEKTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYLGAQGEAHTYASVSIQVNSMVSGDLLFDQLQEH 474
Cdd:cd11273 375 LGGLHVIEGLPLLADSTDGMASVAAYTYRQHSVVFIGTRSGSLKKVRVDGFQDAHLYETVPVVDGSPILRDMVFSPDHRY 454
|
490
....*....|....
gi 2043825702 475 LFVMTQSMVVKVPI 488
Cdd:cd11273 455 IYLLSEKQVSQLPV 468
|
|
| Sema_plexin_D1 |
cd11247 |
The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin ... |
38-486 |
3.17e-41 |
|
The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin receptors and Plexin D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and post-ischemic angiogenesis. Plexin D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. Plexin D1-Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Pssm-ID: 200508 [Multi-domain] Cd Length: 483 Bit Score: 160.01 E-value: 3.17e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 38 SMDLESGTIYLGATNFLFQLT-SDLLLENMVQTGPVLDSKDCLPPvsklECPQA--HH----TDNHNKLLLVNPVQKELI 110
Cdd:cd11247 15 ALDGGRGRLYLAAVNRLYQLSgLVLALEAEAAVGPVLDSPLCHAP----QLPQAtcEHprtlTDNYNKILQPDPEQGVLV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 111 VCGSVHQGICEKRSLASIDHVLFRPESPGDTQY-----VAANDPNITTVGLIAYSKDEV--PLLFVGRGYTSRGVGG--- 180
Cdd:cd11247 91 VCGSIYQGLCQLRRLYNISAVAVRFPVDGDTVFpsmlnVAANHPNASTVGLVLWPRGGGggLRLLVGATYTGYGSGFfpr 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 181 ----------GIPPITTRNLRAHGG-------DVQATDShSIFSYEETAKlAVGRLS---EYNHHFIKSFTYhssvyfLF 240
Cdd:cd11247 171 nrsledhrfeNTPEIAIRALNTRGDlaklftfDINPSDD-NIFKIKQGAK-ARHKLSfvrAFLQHFLQPYAY------LA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 241 YRRDLKSQSREYK--TYISRICLDDSH----------YYSYVELPLLCqskANTYSLLQAAYVTRPGKELaqgqldtege 308
Cdd:cd11247 243 MNGEANAAGKESQppSLLARICLPGRAppppgeakklTESYIQLGLRC---EGAYTRLVSVFPARVEEEQ---------- 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 309 vLFAAFSAWQASsgklseESALCVYTMEEVDRLTNWTRDVCYMrdgkSEEGTEVAYIEYDVSS--------NCVQLPADT 380
Cdd:cd11247 310 -LFAVFERAGGA------PAALCAFRFAEVEEPIRAARTACFV----SPAAGVVTVLDSVVQGtgpacerkLNIQLQPEQ 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 381 LyayPCGSDHTPSPMASRVPLEAAPLLekTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYLGAQGEAHTYASVSIQVNS 460
Cdd:cd11247 379 L---DCGAAHLQHPLAILQPLKATPVF--RAPGLTSVAVASVNNYTVVFLGTVSGRLLKINLDESMQVVSRRSVTVAYGE 453
|
490 500
....*....|....*....|....*....
gi 2043825702 461 MVSGDLLFDQLQE-HLFVMT--QSMVVKV 486
Cdd:cd11247 454 PVHHVMQFDPSDStYLYLMTshQMTRVKV 482
|
|
| Sema_MET_like |
cd11248 |
The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This ... |
43-488 |
1.50e-31 |
|
The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This family includes MET and RON receptor tyrosine kinases. MET is encoded by the c-met protooncogene. MET is the receptor for hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET regulates multiple cellular events and are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a variety of effects including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. MET and RON receptors have been implicated in cancer development and migration. They are composed of alpha-beta heterodimers. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain is necessary for receptor dimerization and activation.
Pssm-ID: 200509 [Multi-domain] Cd Length: 467 Bit Score: 131.00 E-value: 1.50e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 43 SGTIYLGATNFLFQLTSDLLLENMVQTGPVLdSKDCLPPVSKleCPQAHH---TDNHNKLLLVNPVQ-KELIVCGSVHQG 118
Cdd:cd11248 19 STEVYVAAQNVIYALNPDLQKVWEYKTGPVG-SPDCQTCQDC--SSGADPgvpKDTDNMVLVLETYYdDYLYSCGSTQNG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 119 IC-----EKR-SLASIDHVLFRPE---SPGDTQYVAAndPNITTVGLIaySKDEVPLLFVGRGYTSRgVGGGIPP--ITT 187
Cdd:cd11248 96 VCyrhvlEDGaDIQSEVHCLFSKKnnsPSYCPDCVAS--PLGTKVTNV--ESGRTIYFFVANSVNSS-LAGSFPPhsISV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 188 RNLRAHGGDVqatdsHSIFSYeetAKLAVGRLSEYNHHFIKSFTYHSSVYFLFYRRDLKSQ-SREYKTYISRICLDDSHY 266
Cdd:cd11248 171 RRLKEDGFGF-----LSDQSY---LDVLPSLRDSYPIKYVYSFHSGPFVYFLTVQRESLTKpSSAFHTRLVRLCSSDSEI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 267 YSYVELPLLC--------QSKANT--YSLLQAAYVTRPGKELA-QGQLDTEGEVLFAAFSAWQASSGKLSEESALCVYTM 335
Cdd:cd11248 243 WRYREMPLECiftpkrrrRSTEEDvvYNVLQAAHVSKVGADLAdELGASEGDDILFGVFARSKPDSGEPMPNSALCAFPI 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 336 EEVDRLTNWTRDVCYMRDGKSEEGtevayieydvsSNCVQLPADTL--YAYPCGS--DHTPSPMAS---RVPLEAAPLle 408
Cdd:cd11248 323 KYVNDAIEKGVEKCCTSGLEHFSG-----------SLCHFQPCPTCpgESSSCEAtcKEYRTEVTKpyqRVDLFNGQM-- 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 409 kTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYLGAQG-EAHT-YASVSIQVNSMVS-----GDLLFdqlqehlfvMTQS 481
Cdd:cd11248 390 -SNVLLTSILVTTIGNHTVAHLGTSDGRVLQVVLSRSGpIPHVnFSLDSQPVSREVAvlssnGSLLF---------VTGD 459
|
....*..
gi 2043825702 482 MVVKVPI 488
Cdd:cd11248 460 KITKVPL 466
|
|
| IPT_plexin_repeat1 |
cd01180 |
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ... |
1141-1232 |
5.76e-28 |
|
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238585 Cd Length: 94 Bit Score: 109.33 E-value: 5.76e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1141 PLIHSVYPLSGPVEGGTRITITGSNLGQKHQDIAETVTVAGIPCAVDAQEYEISSSIVCITGGSWTERFGHiVVEVPGGG 1220
Cdd:cd01180 1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPVFNG-PVEVTVGH 79
|
90
....*....|....*
gi 2043825702 1221 ---RGVSGHVFTYQN 1232
Cdd:cd01180 80 gsfRTESSEGFSFVD 94
|
|
| Sema_MET |
cd11278 |
The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor ... |
41-488 |
3.08e-27 |
|
The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR); MET is encoded by the c-met protooncogene. MET is a receptor tyrosine kinase that binds its ligand, hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. It also plays a major role in the abnormal migration of cancer cells as a result of overexpression or MET mutations. MET is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The cytoplasmic C-terminal region acts as a docking site for multiple protein substrates, including Grb2, Gab1, STAT3, Shc, SHIP-1 and Src. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. The Sema domain of Met is necessary for receptor dimerization and activation.
Pssm-ID: 200539 [Multi-domain] Cd Length: 492 Bit Score: 118.43 E-value: 3.08e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 41 LESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPP---VSKLECPQAHHTDNHNKLLLVNPV-QKELIVCGSVH 116
Cdd:cd11278 33 LHKHHIYVGAVNKIYVLNEDLQKVSEYKTGPVLEHPDCFPCqdcSDKANLSNGVWKDNVNMALFVETYyDDQLISCGSVN 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 117 QGICEKRSL--------ASIDHVLFRPESPGDtqyvAANDPN--ITTVG--LIAYSKDEVPLLFVGRGYTsrgvGGGIPP 184
Cdd:cd11278 113 RGTCQRHVFphdhpadiQSEVHCIYSPQIEEE----PDQCPDcvVSTLGskVLVTVKDRFVNFFVGNTIN----SSYFPD 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 185 -----ITTRNLR-AHGGDVQATDShsifSYEETakLAVGRLSeYNHHFIKSFTYHSSVYFLFYRRD-LKSQSreYKTYIS 257
Cdd:cd11278 185 hplhsISVRRLKeTQDGFEFLTDQ----SYIDV--LPEFRDS-YPIKYVHAFESNNFVYFLTVQREsLDSQT--FHTRII 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 258 RICLDDSHYYSYVELPLLC---------QSKANTYSLLQAAYVTRPGKELAQGQ-LDTEGEVLFAAFSAWQASSGKLSEE 327
Cdd:cd11278 256 RFCSIDSELRSYMEMPLECiftekrrkrSTKKEVFNILQAAYVSKPGAQLAREMgASLNDDILFGVFAQSKPDSAEPMNR 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 328 SALCVYTMEEVDRLTNWTRDVCYMRDGKSEEGTEVAY-IEYDVSSNcvqlpadtlyAYPCGSDHTPSPMASRVPLEAAPL 406
Cdd:cd11278 336 SAVCAVSIKTINEFFNKIVDKQNVKCLQHFYGKNHEHcFNRTFLRN----------ASYCEARRDEYRVEVTTALQRVDL 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 407 L--EKTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYLGAQGEahTYASVSIQVNSM-VSGDLLFDQLQE---HLFVMTQ 480
Cdd:cd11278 406 FmgQFSNVLLTSISVFTKGDLTIANLGTSEGRFMQVVVSRSGP--STPHVNFLLDSHpVSPEVIVEHTLNqngYTLVITG 483
|
....*...
gi 2043825702 481 SMVVKVPI 488
Cdd:cd11278 484 KKITKIPL 491
|
|
| TIG_plexin |
pfam17960 |
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ... |
549-636 |
7.55e-27 |
|
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.
Pssm-ID: 465588 Cd Length: 89 Bit Score: 105.81 E-value: 7.55e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 549 TPANISREEKRNIFLAISDLPSLreEEFYSCYFEDY-ESPAVLTESGIMCPSPDPSQAPALPTGTDHVTIKLVVRF--HD 625
Cdd:pfam17960 1 TPDNISRTTATQLTLTVPNLPAL--SEGYSCVFGDLtESPATVHDNGVKCATPPPSQLPPIPTGQDHVTVKLSLRSseTG 78
|
90
....*....|.
gi 2043825702 626 IFIASVDFSFY 636
Cdd:pfam17960 79 VDFASTNFTFY 89
|
|
| Sema |
pfam01403 |
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ... |
286-469 |
1.25e-25 |
|
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805
Pssm-ID: 460197 [Multi-domain] Cd Length: 180 Bit Score: 105.82 E-value: 1.25e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 286 LQAAYVTRPGKELAQGqldtegEVLFAAFSAWQASSgklSEESALCVYTMEEVDRLTNwTRDVCYMRDGkSEEGTEVAYI 365
Cdd:pfam01403 1 LQDVFVLKPGAGDALD------TVLYGVFTTQWSNS---IGGSAVCAFSLSDINAVFE-GPFKEQEKSD-SKWLPYTGKV 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 366 EYDVSSNCV------QLPADTLyaypCGSDHTPSPMASRVPLEAAPLLEKTEARLTAVAVN---VEDG-HTIAFLGDSRG 435
Cdd:pfam01403 70 PYPRPGTCIndplrlDLPDSVL----NFVKDHPLMDEAVQPVGGRPLLVRTGVRLTSIAVDrvqALDGnYTVLFLGTDDG 145
|
170 180 190
....*....|....*....|....*....|....*
gi 2043825702 436 RLHKVYLGAQGEAHTYASVSI-QVNSMVSGDLLFD 469
Cdd:pfam01403 146 RLHKVVLVGSEESHIIEEIQVfPEPQPVLNLLLSS 180
|
|
| TIG_2 |
pfam18020 |
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ... |
994-1093 |
3.04e-23 |
|
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.
Pssm-ID: 465619 Cd Length: 94 Bit Score: 95.81 E-value: 3.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 994 GSSLFPVNVARKITLLGKNFHLYQDQQWDYECVLNLEGRTVVMEAYVEGEETnkslcyITCQMNQYSYTAPQLEFSAMVF 1073
Cdd:pfam18020 1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDS------ITCQEHQFSYSGSSGELPATFY 74
|
90 100
....*....|....*....|
gi 2043825702 1074 VQRRRHLRVDSAADLHVTFY 1093
Cdd:pfam18020 75 VTWNGGHRLDNPANLQVVLY 94
|
|
| IPT_plexin_repeat3 |
cd01181 |
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ... |
1323-1445 |
3.99e-20 |
|
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238586 Cd Length: 99 Bit Score: 87.09 E-value: 3.99e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1323 PNITFAEPPKSFLSGGRVLRVHGYNLDVVQKPKIRVTVspserrrrgvgrwrriipdsecpedslcsIQQFEEPCLVNSS 1402
Cdd:cd01181 1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKY-----------------------------GGVEKTSCKVRNS 51
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 2043825702 1403 YLILCKTPAINLLLRS---VRIKLEFILDNLSF-DFNSLHPMPFSYE 1445
Cdd:cd01181 52 TLMTCPAPSLALLNRSpepGERPVEFGLDGDNVqSLLILNRTSFSYY 98
|
|
| IPT_plexin_repeat2 |
cd01179 |
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ... |
1233-1320 |
1.01e-16 |
|
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238584 Cd Length: 85 Bit Score: 76.88 E-value: 1.01e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1233 PELKSIVPTQGPKAGGTCLTLLGSKLLTGhpNEISVLLGDLPCQILSEmTEDQLACQTSPSNVSTELPVIIKYGeQERRL 1312
Cdd:cd01179 1 PSITSLSPSYGPQSGGTRLTITGKHLNAG--SSVRVTVGGQPCKILSV-SSSQIVCLTPPSASPGEAPVKVLID-GARRL 76
|
....*...
gi 2043825702 1313 EGSLFRYT 1320
Cdd:cd01179 77 APLVFTYT 84
|
|
| Sema_RON |
cd11279 |
The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor ... |
42-488 |
3.84e-16 |
|
The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a wide range of effects, including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. RON has been implicated in cancers of the breast, colon, pancreas and ovaries because both splice variants and receptor overexpression have been identified in these tumors. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as ligand recognition and binding model. RON is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain of RON may be necessary for receptor dimerization and activation.
Pssm-ID: 200540 [Multi-domain] Cd Length: 493 Bit Score: 84.06 E-value: 3.84e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 42 ESGTIYLGATNFLFQLTSDL-LLENMVqTGPVlDSKDClppVSKLECPQAHH----TDNHNKLLLVNPVQKELIVCGSVH 116
Cdd:cd11279 37 DASAVFVATRNHLHVLNPELkLLQNLV-TGPT-GSPGC---QICALCPPGPPgpspEDTDNKVLVLDPEEPWLYSCGSSL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 117 QGICEKRSLA---SIDHV-----LFRPE--SPGD-TQYVAAndPNITTVGLIAYSKdeVPLLFVGRGYTSRgVGGGIPP- 184
Cdd:cd11279 112 HGRCFLHELEsrgSAVHIastacLFSANanKPSDcPDCVAS--PLGTRVTVVEQSH--TSYFYVASTLNSS-VAASYSPr 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 185 -ITTRNLRahgGDVQATDS--HSIFSYEEtaklavgRLSEYNHHFIKSFTYHSSVYFLFYRRDlKSQSREYKTYISRICL 261
Cdd:cd11279 187 sVSIRRLK---SDQDGFAPgfHSLTVLPK-------YLDSYPIHYVHSFTSGDFVYFLTVQPE-SPDSSAYHTRLVRLSA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 262 DDSHYYSYVELPLLCQ------------SKANTYSLLQAAYVTRPGKELAqGQLDTEG--EVLFAAFSAWQASSGKLSEE 327
Cdd:cd11279 256 KEPELRDYRELVLDCRfepkrrrrrrpaEREVPYNVLQAAHAAPVGSKLA-VELGISEgqEVLFGVFAESQPGSPVPQKN 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 328 SALCVYTMEEVDRLTNWTRDVCYmrDGKSEEGTEVAYIEYDVSSNCVQLPAdtlyaypcGSDHTPSPMASRVPLEAAPLL 407
Cdd:cd11279 335 SAVCAFPISLLNEAIDEGMEKCC--SSSNSDRLFRGLDFFQPQSYCPHPPN--------LSAAVSNTSCWNFPTLVSTSS 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 408 EKTE--------ARLTAVAVNVEDGHTIAFLGDSRGRLHKVYLGAQGEAHTYAS-VSIQVNSMVSGDllFDQLQEHLFVM 478
Cdd:cd11279 405 FRVDlfnghlsgVLLTSIYVTVLDNVTVAHLGTSDGRILQVVLQRSLNYLLYVSnFSLGDGQPVQRD--VSRLGDSLLFA 482
|
490
....*....|
gi 2043825702 479 TQSMVVKVPI 488
Cdd:cd11279 483 SGNQVFKVNI 492
|
|
| IPT_PCSR |
cd00603 |
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ... |
1141-1231 |
1.67e-15 |
|
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238337 [Multi-domain] Cd Length: 90 Bit Score: 73.64 E-value: 1.67e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1141 PLIHSVYPLSGPVEGGTRITITGSNLGQkhQDIAETVTVAGIPCAVdaqEYEISSSIVCITGGSWTERFGHIVVEV---P 1217
Cdd:cd00603 1 PVITSISPSSGPLSGGTRLTITGSNLGS--GSPRVRVTVGGVPCKV---LNVSSTEIVCRTPAAATPGEGPVEVTVdgaN 75
|
90
....*....|....
gi 2043825702 1218 GGGRGVSGHVFTYQ 1231
Cdd:cd00603 76 VSARVLSNTTFTYV 89
|
|
| PSI |
pfam01437 |
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ... |
491-540 |
4.96e-14 |
|
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).
Pssm-ID: 396154 [Multi-domain] Cd Length: 52 Bit Score: 68.12 E-value: 4.96e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 2043825702 491 CSLYLDCESCLALKDPYCGWCVLQGRCSRRSECLRSRlSEQWLWSFNSTQ 540
Cdd:pfam01437 2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPE-GNCEEWEQASSK 50
|
|
| TIG |
pfam01833 |
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ... |
1141-1230 |
5.35e-14 |
|
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.
Pssm-ID: 460355 [Multi-domain] Cd Length: 84 Bit Score: 69.01 E-value: 5.35e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1141 PLIHSVYPLSGPVEGGTRITITGSNLGQKHQDIaeTVTVAGIPCAVDAQeyeISSSIVCITGGSWTERFGhIVVEVPGGG 1220
Cdd:pfam01833 1 PVITSISPSSGPASGGTTITITGSNFGTDSSDL--KVTIGGTPCTVISV---SSTTIVCTTPPGTSGLVN-VSVTVGGGG 74
|
90
....*....|
gi 2043825702 1221 RGVSGHVFTY 1230
Cdd:pfam01833 75 ISSSPLTFTY 84
|
|
| IPT |
cd00102 |
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ... |
1141-1230 |
3.33e-13 |
|
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.
Pssm-ID: 238050 [Multi-domain] Cd Length: 89 Bit Score: 67.10 E-value: 3.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1141 PLIHSVYPLSGPVEGGTRITITGSNLGqKHQDIaeTVTV-AGIPCAVdaqEYEISSSIVCITGGSWTERFG--HIVVEVP 1217
Cdd:cd00102 1 PVITSISPSSGPVSGGTEVTITGSNFG-SGSNL--RVTFgGGVPCSV---LSVSSTAIVCTTPPYANPGPGpvEVTVDRG 74
|
90
....*....|...
gi 2043825702 1218 GGGRGVSGHVFTY 1230
Cdd:cd00102 75 NGGITSSPLTFTY 87
|
|
| IPT |
smart00429 |
ig-like, plexins, transcription factors; |
1141-1230 |
9.23e-13 |
|
ig-like, plexins, transcription factors;
Pssm-ID: 214657 [Multi-domain] Cd Length: 90 Bit Score: 65.90 E-value: 9.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1141 PLIHSVYPLSGPVEGGTRITITGSNLGqKHQDIAETVTVAGIPCAVDAQEyeiSSSIVCITGGSWTERFGHIVVEVPGGG 1220
Cdd:smart00429 2 PVITRISPTSGPVSGGTEITLCGKNLK-SISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHNIPGSVPVRTVGLRN 77
|
90
....*....|..
gi 2043825702 1221 RGVSG--HVFTY 1230
Cdd:smart00429 78 GGVPSspQPFTY 89
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
686-1007 |
1.23e-12 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 72.69 E-value: 1.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 686 AQIPTSivyPSSAAPLTKSSTTaPTTAPKPVTTPVLVGPSTVPHTEAiHVTPSAASEPTTTTEPTQSPGYTPLTLSTEAA 765
Cdd:pfam17823 112 SRALAA---AASSSPSSAAQSL-PAAIAALPSEAFSAPRAAACRANA-SAAPRAAIAAASAPHAASPAPRTAASSTTAAS 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 766 SLQAATESPLPLPADKPAVTVP-QTTSPAASVLSNPSKNMDHIALPTEGPA--TAQDAWHTDPPTTLGGSPLHTSPVAAV 842
Cdd:pfam17823 187 STTAASSAPTTAASSAPATLTPaRGISTAATATGHPAAGTALAAVGNSSPAagTVTAAVGTVTPAALATLAAAAGTVASA 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 843 -----TPSPQVTSfkwpPSPFPTTEALTSAiSSPQTPS--QVPGSPV-VSDDAPGLPGTelpvsGLPTSAPPQWLLEEGT 914
Cdd:pfam17823 267 agtinMGDPHARR----LSPAKHMPSDTMA-RNPAAPMgaQAQGPIIqVSTDQPVHNTA-----GEPTPSPSNTTLEPNT 336
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 915 ElqdtedwmdllQAENDTSLFSASTLLSGDGDSSERDVPDFPRILHPDLdyqydapefweESEEPSWGPNACPCVQGIQG 994
Cdd:pfam17823 337 P-----------KSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEV-----------EATSPTTQPSPLLPTQGAAG 394
|
330
....*....|....*
gi 2043825702 995 SS--LFPVNVARKIT 1007
Cdd:pfam17823 395 PGilLAPEQVATEAT 409
|
|
| PSI |
smart00423 |
domain found in Plexins, Semaphorins and Integrins; |
490-527 |
4.69e-12 |
|
domain found in Plexins, Semaphorins and Integrins;
Pssm-ID: 214655 [Multi-domain] Cd Length: 47 Bit Score: 62.56 E-value: 4.69e-12
10 20 30
....*....|....*....|....*....|....*...
gi 2043825702 490 ECSLYLDCESCLALKDPYCGWCVLQGRCSRRSECLRSR 527
Cdd:smart00423 1 RCSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRR 38
|
|
| Sema_semaphorin |
cd11235 |
The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator ... |
32-487 |
2.53e-11 |
|
The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. They can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted proteins; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. The semaphorins exert their function through their receptors, the neuropilin and plexin families. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.
Pssm-ID: 200496 [Multi-domain] Cd Length: 437 Bit Score: 68.20 E-value: 2.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 32 TKFLHLSMDLESGTIYLGATN--FLFQLTSDL-LLENMVQTGPvlDSKD-C-LPPVSKLECpqahhtDNHNKLLLVNPvQ 106
Cdd:cd11235 1 LKYHTKLLHEDRSTLYVGARDrvYLVDLDSLYtEQKVAWPSSP--DDVDtCyLKGKSKDDC------RNFIKVLEKNS-D 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 107 KELIVCGS-VHQGICEKRSLASIDHVlfrpESPGDTQYVAANDPNITTVGLiaYSKDEvplLFVGrgyTSRGVGGGIPPI 185
Cdd:cd11235 72 DSLLVCGTnAFNPSCRNYNVETFELV----GKEESGRGKCPYDPDHNSTAL--FADGE---LYSG---TSADFLGTDPVI 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 186 TtRNLRAHGGdvQATDSHSIFSYEETaklavgrlseynhHFIKSFTYHSSVYFlFYRRDlksqSREYKTY-------ISR 258
Cdd:cd11235 140 Y-RTLGHNPP--LRTEYHDSKWLNEP-------------QFVGAFDIGDYVYF-FFREI----AVEYINCgkavysrVAR 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 259 ICLDD--------SHYYSYVELPLLCQSKANT---YSLLQAAYVTrPGKELAQGqldtegeVLFAAFS-AWQASSGklse 326
Cdd:cd11235 199 VCKNDqggsrsleKKWTTFLKARLNCSVPGEFpfyFNELQDVFDL-PSPSNKEK-------IFYAVFTtPYNSIPG---- 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 327 eSALCVYTMEEVDR------------LTNWTRDVCYMRDGKSEEGTevayieYDVSSNcvqLPADTLyayPCGSDHTpsP 394
Cdd:cd11235 267 -SAVCAYSLSDIEAvfngpfkeqhssNSAWLPVPDERVPEPRPGTC------VDDSSP---LPDDTL---NFIKSHP--L 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 395 MASRV-PLEAAPLLEKTEA--RLTAVAVNVEDG-----HTIAFLGDSRGRLHKVYlgAQGEAHTYASVSIQV------NS 460
Cdd:cd11235 332 MDEAVtPILNRPLFIKTDVnyRFTKIAVDRVQAklgqtYDVLFVGTDRGIILKVV--SLPEQGLQASNILEEmpvgppPE 409
|
490 500
....*....|....*....|....*..
gi 2043825702 461 MVSGdLLFDQLQEHLFVMTQSMVVKVP 487
Cdd:cd11235 410 PIQT-MQLSRKRRSLYVGSETGVLQVP 435
|
|
| IPT_PCSR |
cd00603 |
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ... |
1233-1320 |
5.91e-11 |
|
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238337 [Multi-domain] Cd Length: 90 Bit Score: 60.55 E-value: 5.91e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1233 PELKSIVPTQGPKAGGTCLTLLGSKLLTGHPNeISVLLGDLPCQILSEmTEDQLACQTSPSNVSTELPVIIKYGE---QE 1309
Cdd:cd00603 1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPR-VRVTVGGVPCKVLNV-SSTEIVCRTPAAATPGEGPVEVTVDGanvSA 78
|
90
....*....|.
gi 2043825702 1310 RRLEGSLFRYT 1320
Cdd:cd00603 79 RVLSNTTFTYV 89
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
685-907 |
1.58e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 67.27 E-value: 1.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 685 RAQIPTSIVYPSSAA--PLTKSSTTAPTTAPKPVTTPVLVGPSTVPHTEAIHVTPSAASEPTTTTEPTQSP--GYTPLTL 760
Cdd:PHA03247 2609 RGPAPPSPLPPDTHApdPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPpqRPRRRAA 2688
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 761 STEAASLQAATESPLPLPADKPAVT-----VPQTTSPAASVLSNPSKNMDHIALPT-EGPAT-AQDAWHTDPPTTlGGSP 833
Cdd:PHA03247 2689 RPTVGSLTSLADPPPPPPTPEPAPHalvsaTPLPPGPAAARQASPALPAAPAPPAVpAGPATpGGPARPARPPTT-AGPP 2767
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2043825702 834 LHTSPVAAVTPSPQVTsfkwPPSPFPTTEALTSAISSPQTPSQVPGspVVSDDAPGLPGTELPVSGLPTSAPPQ 907
Cdd:PHA03247 2768 APAPPAAPAAGPPRRL----TRPAVASLSESRESLPSPWDPADPPA--AVLAPAAALPPAASPAGPLPPPTSAQ 2835
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
696-907 |
3.26e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 66.12 E-value: 3.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 696 SSAAPLTKSSTTAPTTAP----KPVTTPVLVGPSTvPHTEAIHVTPSAASEPTTTTEPTQSPGYTPLTLSTEA-ASLQAA 770
Cdd:PHA03247 2716 VSATPLPPGPAAARQASPalpaAPAPPAVPAGPAT-PGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAvASLSES 2794
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 771 TES-PLPL-PADKPAV------TVPQTTSPAASVLSNPSknmdhiALPTEGPATAQDawhTDPPTTLGGS---------- 832
Cdd:PHA03247 2795 RESlPSPWdPADPPAAvlapaaALPPAASPAGPLPPPTS------AQPTAPPPPPGP---PPPSLPLGGSvapggdvrrr 2865
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2043825702 833 --PLHTSPVAAVTPSPQVTSFKWPPSPfPTTEALTSAISSPQTPSQvPGSPvvsddAPGLPGTELPVSGLPTSAPPQ 907
Cdd:PHA03247 2866 ppSRSPAAKPAAPARPPVRRLARPAVS-RSTESFALPPDQPERPPQ-PQAP-----PPPQPQPQPPPPPQPQPPPPP 2935
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
689-909 |
3.46e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 66.12 E-value: 3.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 689 PTSIVYPSSAAPLTKSSTTAPTTAPKPVTTPVLVGPSTVPHTEAIHVTPSAASEPTTTTEPTQSPGYTP----LTLSTEA 764
Cdd:PHA03247 2745 PAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLApaaaLPPAASP 2824
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 765 ASLQAATESPLPLPADKPAVTVPQTTSPAASVlsnpSKNMDHIALPTEGPATAQDAWHTDPPT-TLGGSPLHTSPVAAVT 843
Cdd:PHA03247 2825 AGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSV----APGGDVRRRPPSRSPAAKPAAPARPPVrRLARPAVSRSTESFAL 2900
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2043825702 844 PSPQVTSFKWPPSPF-PTTEALTSAISSPQTPSQVPGSPvvsdDAPGLPGTELPVSGLPT-SAPPQWL 909
Cdd:PHA03247 2901 PPDQPERPPQPQAPPpPQPQPQPPPPPQPQPPPPPPPRP----QPPLAPTTDPAGAGEPSgAVPQPWL 2964
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
685-907 |
4.09e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 65.73 E-value: 4.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 685 RAQIPTSIVYPSS--------AAPLTKSSTTAPTTAPKPVTTPVLVGPSTVPHTEAIHVTPSA--ASEPTTTTEPTQSPG 754
Cdd:PHA03247 2666 RARRLGRAAQASSppqrprrrAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAArqASPALPAAPAPPAVP 2745
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 755 YTPLTLSTEAA----SLQAATESPLPlPADKPAVTVPQTTSPAASVLSNPSKNMDHIALPTEGPATAQDAWHTDPPTTLG 830
Cdd:PHA03247 2746 AGPATPGGPARparpPTTAGPPAPAP-PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASP 2824
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 831 GSPLHTSPVAAVTPSPQvtsfkwPPSPFPTTEALTSAIsspqtpsqVPGSPV----VSDDAPGLPGT--ELPVSGLPTSA 904
Cdd:PHA03247 2825 AGPLPPPTSAQPTAPPP------PPGPPPPSLPLGGSV--------APGGDVrrrpPSRSPAAKPAApaRPPVRRLARPA 2890
|
...
gi 2043825702 905 PPQ 907
Cdd:PHA03247 2891 VSR 2893
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
695-906 |
3.47e-09 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 62.48 E-value: 3.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 695 PSSAAPLTKSSTTAP--TTAPKPVTTPVL------------VGPSTVPH---TEAIHVTPSAASEPTTTTEPTQSPGYTP 757
Cdd:pfam03154 243 PSPHPPLQPMTQPPPpsQVSPQPLPQPSLhgqmppmphslqTGPSHMQHpvpPQPFPLTPQSSQSQVPPGPSPAAPGQSQ 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 758 LTLST-----EAASLQAATESPLP-----LPADKPAVTVPQTTSPAASVLSNPSknmdHIAlpteGPATAQDAWHTDPPT 827
Cdd:pfam03154 323 QRIHTppsqsQLQSQQPPREQPLPpaplsMPHIKPPPTTPIPQLPNPQSHKHPP----HLS----GPSPFQMNSNLPPPP 394
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 828 T---LGGSPLHTSPVAAVTP---SPQVTSFKWPPSPFPT---TEALTSAISSPQTPS---QVPGSPVVSDDA--PGLPGT 893
Cdd:pfam03154 395 AlkpLSSLSTHHPPSAHPPPlqlMPQSQQLPPPPAQPPVltqSQSLPPPAASHPPTSglhQVPSQSPFPQHPfvPGGPPP 474
|
250
....*....|...
gi 2043825702 894 ELPVSGLPTSAPP 906
Cdd:pfam03154 475 ITPPSGPPTSTSS 487
|
|
| IPT_plexin_repeat2 |
cd01179 |
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ... |
1141-1230 |
6.86e-09 |
|
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238584 Cd Length: 85 Bit Score: 54.54 E-value: 6.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1141 PLIHSVYPLSGPVEGGTRITITGSNLgqkhqDIAET--VTVAGIPCAVDAQEyeiSSSIVCITGGSWTERFGHIVVEVpG 1218
Cdd:cd01179 1 PSITSLSPSYGPQSGGTRLTITGKHL-----NAGSSvrVTVGGQPCKILSVS---SSQIVCLTPPSASPGEAPVKVLI-D 71
|
90
....*....|..
gi 2043825702 1219 GGRGVSGHVFTY 1230
Cdd:cd01179 72 GARRLAPLVFTY 83
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
685-990 |
6.93e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 61.49 E-value: 6.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 685 RAQIPTSIVYPSSAAPLTKSSTTAPT-TAPKPVTTPVLVGPSTVPhTEAIHVTPSAASEPTTTTEPTQSPGYTPLTLSTE 763
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRESLPSpWDPADPPAAVLAPAAALP-PAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG 2853
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 764 AASLQAATESPLPlPADKPAVTVPQTTSPAASVLSNP--SKNMDHIALPTEGPATAQDAWHTDPPTTLGGSPLHTSPVAA 841
Cdd:PHA03247 2854 GSVAPGGDVRRRP-PSRSPAAKPAAPARPPVRRLARPavSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPP 2932
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 842 VTPSPQVTSfkwPPSPFPTTEAL---TSAISSPQTPSQVPGS-PVVSDDAPG-LPGTELPVS------GLPTSAPPQWLL 910
Cdd:PHA03247 2933 PPPPPRPQP---PLAPTTDPAGAgepSGAVPQPWLGALVPGRvAVPRFRVPQpAPSREAPASstppltGHSLSRVSSWAS 3009
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 911 EEGTELQDTEDWMDLLQA---ENDTSLFSASTLLSGDGDSSERDVPDfprilhPDLDYQYDAPEFWEESEEPSWGPNACP 987
Cdd:PHA03247 3010 SLALHEETDPPPVSLKQTlwpPDDTEDSDADSLFDSDSERSDLEALD------PLPPEPHDPFAHEPDPATPEAGARESP 3083
|
...
gi 2043825702 988 CVQ 990
Cdd:PHA03247 3084 SSQ 3086
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
688-906 |
7.47e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 61.49 E-value: 7.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 688 IPTSIVYPSSAAPLTKSSTTAPTTAPKPVTTPVLVGPSTVPHteaihvTPSAASEPTTTTEPTQSPGYTPLTLSTEAASL 767
Cdd:PHA03247 2568 VPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPR------GPAPPSPLPPDTHAPDPPPPSPSPAANEPDPH 2641
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 768 QAATESPLPLPADKPA---VTVPQTTSP---AASVLSNPSKNMDHIALPTEGPATAQdAWHTDPPTTLGGSPLHTSPVAA 841
Cdd:PHA03247 2642 PPPTVPPPERPRDDPApgrVSRPRRARRlgrAAQASSPPQRPRRRAARPTVGSLTSL-ADPPPPPPTPEPAPHALVSATP 2720
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2043825702 842 VTPSPQVTSFKWPPSPF-PTTEALTSAISSPQTPSQvPGSPVVSDDAPGLPGTELPVSGLPTSAPP 906
Cdd:PHA03247 2721 LPPGPAAARQASPALPAaPAPPAVPAGPATPGGPAR-PARPPTTAGPPAPAPPAAPAAGPPRRLTR 2785
|
|
| RasGAP |
cd04519 |
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ... |
1987-2129 |
9.83e-09 |
|
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213328 Cd Length: 256 Bit Score: 58.66 E-value: 9.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1987 EIYLTRLLSMKGTLQKFVDDLFQVILSTNRPVPLAVKYFFDLLDEQAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQ- 2065
Cdd:cd04519 115 LPVGEDLEENLENLLELVNKLVDRILSSLDRLPPELRYVFKILREFLAERFPEEPDEAYQAVSGFLFLRFICPAIVSPEl 194
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2043825702 2066 -FVFDVQTSDNVDAVLLVIAQTFMDSCTiadhklgRDSPINKLLYARD----IPRYKQMVERYYADIRQ 2129
Cdd:cd04519 195 fGLVPDEPSEQARRNLTLISKVLQSLAN-------GVEFGDKEPFMKPlndfIKSNKPKLKQFLDELSS 256
|
|
| Sema_4 |
cd11240 |
The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 ... |
236-488 |
2.39e-08 |
|
The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 semaphorins (Sema4s) are transmembrane regulator molecules involved in the development of the nervous system, immune response, cytoskeletal organization, angiogenesis, and cell-cell interactions. There are 7 distinct subfamilies in class 4 semaphorins, named 4A to 4G. Several class 4 subfamilies play important roles in the immune system and are called "immune semaphorins". Sema4A plays critical roles in T cell-DC interactions in the immune response. Sema4D/CD100, expressed by lymphocytes, promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. It is required for normal activation of B and T lymphocytes. Sema4B negatively regulates basophil functions through T cell-basophil contacts and significantly inhibits IL-4 and IL-6 production from basophils in response to various stimuli, including IL-3 and papain. Sema4s not only influence the activation state of cells but also modulate their migration and survival. The effects of Sema4s on nonlymphoid cells are mediated by plexin D1 and plexin Bs. The Sema4G and Sema4C genes are expressed in the developing cerebellar cortex and are involved in neural tube closure and development of cerebellar granules cells through receptor plexin B2. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.
Pssm-ID: 200501 [Multi-domain] Cd Length: 456 Bit Score: 58.96 E-value: 2.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 236 VYFLFYRRdlksqSREYKTY-------ISRICLDD--------SHYYSYVELPLLCQSKANT--YSLLQAAYVTRPGkel 298
Cdd:cd11240 193 IYFFFTET-----AVEYDFYekvtvsrVARVCKGDlggqrtlqKKWTTFLKAQLVCSQPDSGlpFNVLRDVFVLSPD--- 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 299 aqgqlDTEGEVLFAAFSA-WQASSGklseeSALCVYTMEEVDRL------------TNWTR---DVCYMRDGKSeeGTEV 362
Cdd:cd11240 265 -----SWDATIFYGVFTSqWNVSGL-----SAVCAYSLEDIKKVfsgkykefnretSKWSRytgPVPDPRPGAC--ITNS 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 363 AYIEYDVSSncVQLPADTLYAYpcgSDHtpsP-MASRVPLEAAPLLEKTEARLTAVAVNVEDG-----HTIAFLGDSRGR 436
Cdd:cd11240 333 ARSQGITSS--LNLPDNVLTFV---KDH---PlMDEQVHPINRPLLVKSGVNYTRIAVHRVQAldgqtYTVLFLGTEDGF 404
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 2043825702 437 LHKVYLGAqGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPI 488
Cdd:cd11240 405 LHKAVSLD-GGMHIIEEIQLFDQPQPVKNLLLSSSKGVLYVGSSSGVVQVPL 455
|
|
| IPT |
cd00102 |
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ... |
1233-1320 |
2.81e-08 |
|
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.
Pssm-ID: 238050 [Multi-domain] Cd Length: 89 Bit Score: 53.23 E-value: 2.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1233 PELKSIVPTQGPKAGGTCLTLLGSKLLTGhpNEISVLL-GDLPCQILSEmTEDQLACQTSPSNVSTELPVII--KYGEQE 1309
Cdd:cd00102 1 PVITSISPSSGPVSGGTEVTITGSNFGSG--SNLRVTFgGGVPCSVLSV-SSTAIVCTTPPYANPGPGPVEVtvDRGNGG 77
|
90
....*....|.
gi 2043825702 1310 RRLEGSLFRYT 1320
Cdd:cd00102 78 ITSSPLTFTYV 88
|
|
| TIG |
pfam01833 |
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ... |
1233-1319 |
3.22e-08 |
|
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.
Pssm-ID: 460355 [Multi-domain] Cd Length: 84 Bit Score: 52.83 E-value: 3.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1233 PELKSIVPTQGPKAGGTCLTLLGSKLLTGHPNeISVLLGDLPCQILSeMTEDQLACQTsPSNVSTELPVIIKYGEQERRL 1312
Cdd:pfam01833 1 PVITSISPSSGPASGGTTITITGSNFGTDSSD-LKVTIGGTPCTVIS-VSSTTIVCTT-PPGTSGLVNVSVTVGGGGISS 77
|
....*..
gi 2043825702 1313 EGSLFRY 1319
Cdd:pfam01833 78 SPLTFTY 84
|
|
| IPT |
smart00429 |
ig-like, plexins, transcription factors; |
1322-1444 |
7.00e-08 |
|
ig-like, plexins, transcription factors;
Pssm-ID: 214657 [Multi-domain] Cd Length: 90 Bit Score: 52.04 E-value: 7.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1322 DPNITFAEPPKSFLSGGRVLRVHGYNLDVVQKPKIRVTVSPSErrrrgvgrwrriipdsecpedslCSIQQfeepclvNS 1401
Cdd:smart00429 1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAP-----------------------CTFSP-------SS 50
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2043825702 1402 SYLILCKTPAINLLLRSVRI-KLEFILDNLSFDfnslhPMPFSY 1444
Cdd:smart00429 51 STAIVCKTPPYHNIPGSVPVrTVGLRNGGVPSS-----PQPFTY 89
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
695-908 |
7.48e-08 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 57.96 E-value: 7.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 695 PSSAAPLTKSSTTAPTTAPKPVTTPvlvgPSTVPHTEAIHVTPSAASEPTTTTEPTQSPGYTPLTLSTEA-----ASLQA 769
Cdd:PRK12323 374 PATAAAAPVAQPAPAAAAPAAAAPA----PAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQAsargpGGAPA 449
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 770 ATESPLPLPADKPAVTVPQTTSPAASVLSNPSKnmdhiALPTEGPATAQDA---WHTDPPTTLGGSPlhtSPVAAVTPSP 846
Cdd:PRK12323 450 PAPAPAAAPAAAARPAAAGPRPVAAAAAAAPAR-----AAPAAAPAPADDDpppWEELPPEFASPAP---AQPDAAPAGW 521
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2043825702 847 QVTSFKWPPSPFPTTEALTSAISSPQTPSQVPGSPVVSDDAPGLPgtELPVSGLPTSAPPQW 908
Cdd:PRK12323 522 VAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPP--RASASGLPDMFDGDW 581
|
|
| Chi1 |
COG3469 |
Chitinase [Carbohydrate transport and metabolism]; |
693-896 |
2.63e-07 |
|
Chitinase [Carbohydrate transport and metabolism];
Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 55.91 E-value: 2.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 693 VYPSSAAPLTKSSTTAPTTAPKPVTTPVLVGPSTVPHTEAIHVTPSAASEPTTTTEPTQSPGYTPLTLSTEAASLQAATE 772
Cdd:COG3469 12 AGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATS 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 773 SPLPLPADKPAVTVPQTTSPAASVLSNPSKNMDhIALPTEGPATAQDAWHTDPPTTLGGSPLHTSPVAAVTPSPQVTSFK 852
Cdd:COG3469 92 TSATLVATSTASGANTGTSTVTTTSTGAGSVTS-TTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTT 170
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 2043825702 853 WPPSPFPTTEALTSAISSPQTPSQVPGSPVVSDDAPGlPGTELP 896
Cdd:COG3469 171 TTTSASTTPSATTTATATTASGATTPSATTTATTTGP-PTPGLP 213
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
700-907 |
2.84e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 55.93 E-value: 2.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 700 PLTKSSTTAPTTAPKPVTTPVLVGPSTVPHTEAIHVTPSAASEPTTTTEPTQSPGyTPLTLSTEAASLQA----ATESPL 775
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTA-APHTLIQQTPTLHPqrlpSPHPPL 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 776 -PLPADKPAVTVPQTTSPAASvLSNPSKNMDHiALPTeGPATAQdawHTDPPTTLGGSPLHTSPVAAVTPSPQVTSfkwP 854
Cdd:pfam03154 250 qPMTQPPPPSQVSPQPLPQPS-LHGQMPPMPH-SLQT-GPSHMQ---HPVPPQPFPLTPQSSQSQVPPGPSPAAPG---Q 320
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 2043825702 855 PSPFPTTEALTSAISSPQTPSQVPGSPvvsddAP-GLPGTELPvsglPTSAPPQ 907
Cdd:pfam03154 321 SQQRIHTPPSQSQLQSQQPPREQPLPP-----APlSMPHIKPP----PTTPIPQ 365
|
|
| MISS |
pfam15822 |
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ... |
697-892 |
3.80e-07 |
|
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.
Pssm-ID: 318115 [Multi-domain] Cd Length: 238 Bit Score: 53.45 E-value: 3.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 697 SAAPLTKSSTTAPTTAPK-------------PVTTPVLVGPSTVPHTeaIHVTPSAASEPTTTTEPTQSPGYTPLTLSTE 763
Cdd:pfam15822 11 SPAKTSAVSNPKPGQPPQgwpgsnpwnnpsaPPAVPSGLPPSTAPST--VPFGPAPTGMYPSIPLTGPSPGPPAPFPPSG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 764 AASLQAATESPLPL--------PADKPAVTVPQ-------TTSPAASVLSNPSKNMD---------------HIALPTEG 813
Cdd:pfam15822 89 PSCPPPGGPYPAPTvpgpgpigPYPTPNMPFPElprpygaPTDPAAAAPSGPWGSMSsgpwapgmggqypapNMPYPSPG 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 814 PATAqdawhTDPPTTLGGSPlhTSPVAAVTPSPqvtsfkW-PPSPFPTTEALTSA---ISSPQTPSQVPGSPvvsDDAPG 889
Cdd:pfam15822 169 PYPA-----VPPPQSPGAAP--PVPWGTVPPGP------WgPPAPYPDPTGSYPMpglYPTPNNPFQVPSGP---SGAPP 232
|
...
gi 2043825702 890 LPG 892
Cdd:pfam15822 233 MPG 235
|
|
| IPT |
smart00429 |
ig-like, plexins, transcription factors; |
1232-1320 |
8.03e-07 |
|
ig-like, plexins, transcription factors;
Pssm-ID: 214657 [Multi-domain] Cd Length: 90 Bit Score: 48.96 E-value: 8.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1232 NPELKSIVPTQGPKAGGTCLTLLGSKLLTGHPNEISVLLGDLPCQILSEmTEDQLACQTSPSNVST-ELPVI-IKYGEQE 1309
Cdd:smart00429 1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAPCTFSPS-SSTAIVCKTPPYHNIPgSVPVRtVGLRNGG 79
|
90
....*....|.
gi 2043825702 1310 RRLEGSLFRYT 1320
Cdd:smart00429 80 VPSSPQPFTYV 90
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
687-906 |
1.24e-06 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 53.77 E-value: 1.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 687 QIPTSIVYPSSAAPltkSSTTAPTTAPKPVTT-----PVLVGPS-------------TVPHTEAIHVTPSAASepTTTTE 748
Cdd:pfam05109 453 HVPTNLTAPASTGP---TVSTADVTSPTPAGTtsgasPVTPSPSprdngteskapdmTSPTSAVTTPTPNATS--PTPAV 527
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 749 PTQSPGYTPLTLSTEAASLQAATESP---LPLPA---DKPAVTVPQ--TTSPAASVlSNPSKNMDHialPTEGPATAQdA 820
Cdd:pfam05109 528 TTPTPNATSPTLGKTSPTSAVTTPTPnatSPTPAvttPTPNATIPTlgKTSPTSAV-TTPTPNATS---PTVGETSPQ-A 602
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 821 WHTDppTTLGGsplhTSPVAAVTPSPQVTSFKWPPSPFPTTEALTSAIS-SPQTPSQVPgSPVVSDDAPglpgTELPvsg 899
Cdd:pfam05109 603 NTTN--HTLGG----TSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSlRPSSISETL-SPSTSDNST----SHMP--- 668
|
....*..
gi 2043825702 900 LPTSAPP 906
Cdd:pfam05109 669 LLTSAHP 675
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
689-908 |
2.20e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 52.93 E-value: 2.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 689 PTSIVYPSSAAPLTKSSTTAPTTAPKPVT-----TPVLVGPSTVPHTEAIHVTPSAASeptttteptQSPGYTPLTLSTE 763
Cdd:PRK07003 406 AGAALAPKAAAAAAATRAEAPPAAPAPPAtadrgDDAADGDAPVPAKANARASADSRC---------DERDAQPPADSGS 476
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 764 AASLQAATESPLPLPADKPAVTVPQTTSPAASVLSNPSKnmdhIALPTEGPATAQDAWHTDPPTTLGGSPLHTSPVAAV- 842
Cdd:PRK07003 477 ASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAA----ASREDAPAAAAPPAPEARPPTPAAAAPAARAGGAAAa 552
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2043825702 843 -----TPSPQVTSFKW--------PPSPFPTTEalTSAISSPQTPSQVPGSPVVSDDAPGLPGTELPVSGLPTSAPPQW 908
Cdd:PRK07003 553 ldvlrNAGMRVSSDRGaraaaaakPAAAPAAAP--KPAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAESRGAPPPW 629
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
695-905 |
2.37e-06 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 53.23 E-value: 2.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 695 PSSAAPLTKSSTTAPTTAPKPvTTPVLVGPSTVPHTEAIHVtpSAASEPTTTTEPTQSPGYTPLT-LSTE------AASL 767
Cdd:pfam03154 339 PPREQPLPPAPLSMPHIKPPP-TTPIPQLPNPQSHKHPPHL--SGPSPFQMNSNLPPPPALKPLSsLSTHhppsahPPPL 415
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 768 QAATES-PLPL-PADKPAVTVPQTTSPAASvlSNPSKNMDHialptEGPATAQDAWHTDPPttlGGSPLHTSPVAAVTPS 845
Cdd:pfam03154 416 QLMPQSqQLPPpPAQPPVLTQSQSLPPPAA--SHPPTSGLH-----QVPSQSPFPQHPFVP---GGPPPITPPSGPPTST 485
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2043825702 846 PQVTSFKWPPSPFPTTEALT--SAISSPQTPSQVPGSPVvsdDAPGLPGTELPVSGLPTSAP 905
Cdd:pfam03154 486 SSAMPGIQPPSSASVSSSGPvpAAVSCPLPPVQIKEEAL---DEAEEPESPPPPPRSPSPEP 544
|
|
| PRK08691 |
PRK08691 |
DNA polymerase III subunits gamma and tau; Validated |
736-995 |
2.70e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236333 [Multi-domain] Cd Length: 709 Bit Score: 52.79 E-value: 2.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 736 TPSAASEPTTTTEPTQSPGYTPltlSTEAASLQAATESPLPLPADKPAVTVPQTTSPAasvlsnpsknmdhiALPTEGpA 815
Cdd:PRK08691 359 APLAAASCDANAVIENTELQSP---SAQTAEKETAAKKPQPRPEAETAQTPVQTASAA--------------AMPSEG-K 420
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 816 TAQdawhtdpPTTLG----GSPLHTSPVAAVTPSPqvtsfkwppsPFPTTEALTSAISSPQTPsqvPGSPVVSDDAPGlP 891
Cdd:PRK08691 421 TAG-------PVSNQenndVPPWEDAPDEAQTAAG----------TAQTSAKSIQTASEAETP---PENQVSKNKAAD-N 479
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 892 GTELPVSGLPTSAPPQwlleegtelqdtedwmdllQAENDTSLFSASTllsgdgdSSERDVPDFPRILHPDLDYQydaPE 971
Cdd:PRK08691 480 ETDAPLSEVPSENPIQ-------------------ATPNDEAVETETF-------AHEAPAEPFYGYGFPDNDCP---PE 530
|
250 260
....*....|....*....|....
gi 2043825702 972 FWEESEEPSWgPNACPCVQGIQGS 995
Cdd:PRK08691 531 DGAEIPPPDW-EHAAPADTAGGGA 553
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
685-921 |
2.75e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 52.57 E-value: 2.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 685 RAQIPTSIVYPSSAAPLTKSSTTAPTTAPKPVTTPVLVGPSTVPHTEAIHVTPSAASEPTTTTEPTQSPGYTPltLSTEA 764
Cdd:PRK12323 382 VAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAP--AAAPA 459
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 765 ASLQAATESPLPLPAdkPAVTVPQTTSPAASVLSNPSKNMDHIALPTEGPATAQDAwhTDPPTTLGGSPLHTSPVAAVTP 844
Cdd:PRK12323 460 AAARPAAAGPRPVAA--AAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQ--PDAAPAGWVAESIPDPATADPD 535
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 845 SPQVTSFKWPP-SPFPTTEALTSAISSPQTPSQ-VPGSPVVSD-DAPGLPGTeLPVSGLPTSAPPQwlleegTELQDTED 921
Cdd:PRK12323 536 DAFETLAPAPAaAPAPRAAAATEPVVAPRPPRAsASGLPDMFDgDWPALAAR-LPVRGLAQQLARQ------SELAGVEG 608
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
701-907 |
8.78e-06 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 51.07 E-value: 8.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 701 LTKSSTTAPTTAPKPVTTPVLVGPSTVPHTEaihvTPSAASEPTTTTEPTQSPGYTPLTLSTEAASLQAATESPLPLPAD 780
Cdd:pfam05109 405 ITRTATNATTTTHKVIFSKAPESTTTSPTLN----TTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAG 480
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 781 KPAVTVPQTTSPAASVLSNPSKNMDH------IALPTEGPATAQDAWHTDPPTTLGGSPLHTSPVAAVT--------PSP 846
Cdd:pfam05109 481 TTSGASPVTPSPSPRDNGTESKAPDMtsptsaVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTtptpnatsPTP 560
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2043825702 847 QVTSfkwpPSPFPTTEAL--TSAISSPQTPSQVPGSPVVSDDAPGLPGTELPVSGLPT----SAPPQ 907
Cdd:pfam05109 561 AVTT----PTPNATIPTLgkTSPTSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSStpvvTSPPK 623
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
684-881 |
1.51e-05 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 50.31 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 684 ERAQIPTSIVYPSSAAP----------LTKSSTTAPTTA---PKPVTTPVLVGPSTVPHTeaihVTPSAASEPTTTTEPT 750
Cdd:PLN03209 338 GPKPVPTKPVTPEAPSPpieeeppqpkAVVPRPLSPYTAyedLKPPTSPIPTPPSSSPAS----SKSVDAVAKPAEPDVV 413
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 751 QSPGYTPLTLSTEAASLQAATESPLPLPADKPAVTVPQTTSPAASVLSNPSKNMDHIALPTEGPATAQDAWHTDPPTTLG 830
Cdd:PLN03209 414 PSPGSASNVPEVEPAQVEAKKTRPLSPYARYEDLKPPTSPSPTAPTGVSPSVSSTSSVPAVPDTAPATAATDAAAPPPAN 493
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2043825702 831 GSPLHTSPVAA-----VTPSPQVTSFKWPPSPFPttEALTSAISSPQT----------PSQVPGSP 881
Cdd:PLN03209 494 MRPLSPYAVYDdlkppTSPSPAAPVGKVAPSSTN--EVVKVGNSAPPTaladeqhhaqPKPRPLSP 557
|
|
| Sema_6 |
cd11242 |
The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 ... |
225-488 |
4.28e-05 |
|
The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 semaphorins (Sema6s) are membrane associated semaphorins. There are 6 subfamilies named 6A to 6D. Sema6s bind to plexin As in a neuropilin independent fashion. Sema6-plexin A signaling plays important roles in lamina-specific axon projections. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. Interactions between Sema6C, Sema6D and plexin A1 shape the stereotypic trajectories of sensory axons in the spinal cord. In addition to axon targeting, Sema6D-plexin A1 interactions influence a wide range of other biological processes. During cardiac development, Sema6D attracts or repels endothelial cells in the cardiac tube depending on the expression patterns of specific coreceptors in addition to plexin A1. Furthermore, Sema6D binds a receptor complex comprising of plexin A1, Trem2 (triggering receptor expressed on myeloid cells 2), and DAP12 on dendritic cells and osteoclasts to mediate T-cell-DC interactions and to control bone development, respectively. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.
Pssm-ID: 200503 [Multi-domain] Cd Length: 465 Bit Score: 48.67 E-value: 4.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 225 HFIKSFTYHSSVYFLFyrRDLksqSREYKTY-------ISRICLDD---------SHYYSYVELPLLCQSKANT---YSL 285
Cdd:cd11242 174 HFVHAVEYGDYVYFFF--REI---AVEYNTLgkvvfsrVARVCKNDmggsprvleKQWTSFLKARLNCSVPGDShfyFDV 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 286 LQAayVTRPgkelaqgqLDTEG-EVLFAAFSAwQASSgklSEESALCVYTMEEVDRLTN------------WT------- 345
Cdd:cd11242 249 LQA--VTDV--------IRINGrPVVLGVFTT-QYNS---IPGSAVCAFDMDDIEKVFEgrfkeqkspdsaWTpvpedrv 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 346 ---RDVCYMRDGKSEegtevayiEYDVSSNcvqLPADTL---YAYPCgsdhtpspMASRVP-LEAAPLLEKT--EARLTA 416
Cdd:cd11242 315 pkpRPGCCAGSGSAE--------KYKTSND---FPDDTLnfiKTHPL--------MDEAVPsIINRPWFTRTmvRYRLTQ 375
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 417 VAVNVEDG----HTIAFLGDSRGRLHKVyLGAQGEAHTYASVSIQVNSMVSGD--------------LLFDQLQEHLFVM 478
Cdd:cd11242 376 IAVDNAAGpyqnYTVVFLGSEAGTVLKF-LARIGPSGSNGSVFLEEIDVYNPAkcsydgeedrriigLELDRASHALFVA 454
|
330
....*....|
gi 2043825702 479 TQSMVVKVPI 488
Cdd:cd11242 455 FSGCVIRVPL 464
|
|
| PRK12727 |
PRK12727 |
flagellar biosynthesis protein FlhF; |
689-877 |
5.65e-05 |
|
flagellar biosynthesis protein FlhF;
Pssm-ID: 237182 [Multi-domain] Cd Length: 559 Bit Score: 48.06 E-value: 5.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 689 PTSIVYPSSAAPLTKSST--TAPTTAPKPVTTPVLVGPSTVPHTEAIHVTpSAASEPTTTTEPTQSPGYTPLTLSTE--- 763
Cdd:PRK12727 60 SDTPATAAAPAPAPQAPTkpAAPVHAPLKLSANANMSQRQRVASAAEDMI-AAMALRQPVSVPRQAPAAAPVRAASIpsp 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 764 --AASLQAATESPLPLP------------ADKPA-VTVPQTTSPAASVLSNPsknmDHIALPTEGPATAQDAWHTDPPTT 828
Cdd:PRK12727 139 aaQALAHAAAVRTAPRQehalsavpeqlfADFLTtAPVPRAPVQAPVVAAPA----PVPAIAAALAAHAAYAQDDDEQLD 214
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 2043825702 829 LGGSPLHTSPVAAVTPSPQVTSFKWPPSPfPTTEALTSAISSPQTPSQV 877
Cdd:PRK12727 215 DDGFDLDDALPQILPPAALPPIVVAPAAP-AALAAVAAAAPAPQNDEEL 262
|
|
| PSI |
pfam01437 |
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ... |
1094-1133 |
9.20e-05 |
|
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).
Pssm-ID: 396154 [Multi-domain] Cd Length: 52 Bit Score: 41.92 E-value: 9.20e-05
10 20 30 40
....*....|....*....|....*....|....*....|
gi 2043825702 1094 NCSvGHTDCSRCQTADSkYNCVWCGGDNpSCIFRGSCKEE 1133
Cdd:pfam01437 1 RCS-QYTSCSSCLAARD-PYCGWCSSEG-RCVRRSACGAP 37
|
|
| PSI |
smart00423 |
domain found in Plexins, Semaphorins and Integrins; |
1094-1139 |
9.45e-05 |
|
domain found in Plexins, Semaphorins and Integrins;
Pssm-ID: 214655 [Multi-domain] Cd Length: 47 Bit Score: 41.76 E-value: 9.45e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1094 NCSVgHTDCSRCQTADSKYnCVWCGGDNpSCIFRGSCKEEVEDL----CP 1139
Cdd:smart00423 1 RCSK-YTSCSECLLARDPY-CAWCSSQG-RCTSGERCDSRRQNWlsggCP 47
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
696-907 |
1.67e-04 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 46.98 E-value: 1.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 696 SSAAPltkSSTTAPTTAPKPVTTPVlvGPST---VPHTEAIHVTPSAASEPTTTTEPTQSPGYTPLTLSTEAASLQAATE 772
Cdd:PHA03378 586 ASSAP---SYAQTPWPVPHPSQTPE--PPTTqshIPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEIT 660
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 773 SPLPLPADKPAVTV-PQTTSPAASVLsnpsknmdhialPTEGPATAQdawhtdPPTTLGG--SPLHTSPVAAVTPSPQVT 849
Cdd:PHA03378 661 PYKPTWTQIGHIPYqPSPTGANTMLP------------IQWAPGTMQ------PPPRAPTpmRPPAAPPGRAQRPAAATG 722
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 2043825702 850 SFKwPPSPFPTTEALTSAISSPQTPSQvpGSPVVSDDAPGLPGTELPVSGLPTSAPPQ 907
Cdd:PHA03378 723 RAR-PPAAAPGRARPPAAAPGRARPPA--AAPGRARPPAAAPGRARPPAAAPGAPTPQ 777
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
693-906 |
1.78e-04 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 46.46 E-value: 1.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 693 VYPSSAAPLT---KSSTTAPTTAPKPVTTPVLVGPSTVPHTEAIHVTPSAASEPTTTTEPTQSPgyTPLTLSTEAASLQA 769
Cdd:PLN03209 305 VIAETTAPLTpmeELLAKIPSQRVPPKESDAADGPKPVPTKPVTPEAPSPPIEEEPPQPKAVVP--RPLSPYTAYEDLKP 382
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 770 ATeSPLPLPadkpavtvpqTTSPAASvlsnpSKNMDHIALPTEgpataqdawhTDPPTtlggSPLHTSPVAAVTPSPQVT 849
Cdd:PLN03209 383 PT-SPIPTP----------PSSSPAS-----SKSVDAVAKPAE----------PDVVP----SPGSASNVPEVEPAQVEA 432
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 2043825702 850 SFKWPPSPFPTTEALTSAIS-SPQTPSQVPGSPVVSDDAPGLPGTELPVSGLPTSAPP 906
Cdd:PLN03209 433 KKTRPLSPYARYEDLKPPTSpSPTAPTGVSPSVSSTSSVPAVPDTAPATAATDAAAPP 490
|
|
| IPT_plexin_repeat1 |
cd01180 |
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ... |
1233-1311 |
2.13e-04 |
|
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238585 Cd Length: 94 Bit Score: 42.30 E-value: 2.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1233 PELKSIVPTQGPKAGGTCLTLLGSKLltG-HPNEI--SVLLGDLPCQIL--SEMTEDQLACQTSPS-NVSTELPVIIKYG 1306
Cdd:cd01180 1 PVITEFFPLSGPLEGGTRLTICGSNL--GlRKNDVrhGVRVGGVPCNPEppEYSSSEKIVCTTGPAgNPVFNGPVEVTVG 78
|
....*
gi 2043825702 1307 EQERR 1311
Cdd:cd01180 79 HGSFR 83
|
|
| RasGAP |
cd04519 |
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ... |
1684-1794 |
3.69e-04 |
|
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.
Pssm-ID: 213328 Cd Length: 256 Bit Score: 44.40 E-value: 3.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1684 LFLTKFIHTL--EIQRTFSPRDRAYVASLLTVSLHGKlEYFTDILKTLLNDLVEQyvAKNPKLMLRRTeTVVEKLLTNWM 1761
Cdd:cd04519 8 LLLTESPLALlrELSQVLPVKDKEEVATALLRIFESR-GLALEFLRYLVRSEVKN--TKNPNTLFRGN-SLATKLLDQYM 83
|
90 100 110
....*....|....*....|....*....|...
gi 2043825702 1762 SICLYAFVRDSVGEPLYMLFRGIKHQVDKGPVD 1794
Cdd:cd04519 84 KLVGQEYLKETLSPLIREILESKESCEIDTKLP 116
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
686-896 |
5.69e-04 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 45.06 E-value: 5.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 686 AQIPTSIVYPS--SAAPLTKS---STTAPTTAP-------------KPVTTPVLVGPST--VPHTEAIHVTPSAASEPTT 745
Cdd:PHA03378 593 AQTPWPVPHPSqtPEPPTTQShipETSAPRQWPmplrpipmrplrmQPITFNVLVFPTPhqPPQVEITPYKPTWTQIGHI 672
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 746 TTEPTQSPGYTPLTLSTEAASLQAATESPLPLPADKPAVTVPQ----TTSPAASVLSNPSKNMDHIALPTEGPATAQDAW 821
Cdd:PHA03378 673 PYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQrpaaATGRARPPAAAPGRARPPAAAPGRARPPAAAPG 752
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2043825702 822 HTDPPTtlgGSPLHTSPVAAV--TPSPQVtsfkwPPSPFPTTEALTSAISSPQTPSQVPGSPVVSdDAPGLPGTELP 896
Cdd:PHA03378 753 RARPPA---AAPGRARPPAAApgAPTPQP-----PPQAPPAPQQRPRGAPTPQPPPQAGPTSMQL-MPRAAPGQQGP 820
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
689-913 |
7.27e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 45.08 E-value: 7.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 689 PTSIVYPSSAAPLTKSSTTAPTTAPKPVTTPVLVGPSTVPHTEAIHVTPSAASEPTTTTEPTQSP--GYTPLTLSTEAAS 766
Cdd:PRK10263 336 PVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPvqPQQPYYAPAAEQP 415
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 767 LQAATESPLPLPADKPAVTVPQTTSPAASVLSNPSKNMDHIA-LPTEGPAT------AQDAWHTDPPTTLGGSPLHTSPV 839
Cdd:PRK10263 416 AQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFApQSTYQTEQtyqqpaAQEPLYQQPQPVEQQPVVEPEPV 495
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 840 AAVT-PS------------------PQVTSFKWP-PSPFPTTEALTSAISSPQTPSQVP--GSPVVSDDAPGLPGTELPV 897
Cdd:PRK10263 496 VEETkPArpplyyfeeveekrarerEQLAAWYQPiPEPVKEPEPIKSSLKAPSVAAVPPveAAAAVSPLASGVKKATLAT 575
|
250
....*....|....*.
gi 2043825702 898 SGLPTSAPPQWLLEEG 913
Cdd:PRK10263 576 GAAATVAAPVFSLANS 591
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
695-906 |
7.88e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 44.78 E-value: 7.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 695 PSSAAPLTKSSTTAPTTAPKPVTTPVLVGPSTVPhteaihvTPSAASEPTTTTeptQSPGYTPLTLSTEAASLQAATESP 774
Cdd:PHA03307 151 SPPAAGASPAAVASDAASSRQAALPLSSPEETAR-------APSSPPAEPPPS---TPPAAASPRPPRRSSPISASASSP 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 775 LPLPADKPAVTVPQTTSPAASVLSNPSKNMDHIALPTEGPATAQDA---WHTDPPTTLGGSPLHTSPVAAVTPSPQVTSF 851
Cdd:PHA03307 221 APAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPtriWEASGWNGPSSRPGPASSSSSPRERSPSPSP 300
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 2043825702 852 KWPPSPFPTTEALTSAISSPQTPSQVPG---SPVVSDDAPGLPGTELPVSGLPTSAPP 906
Cdd:PHA03307 301 SSPGSGPAPSSPRASSSSSSSRESSSSStssSSESSRGAAVSPGPSPSRSPSPSRPPP 358
|
|
| IPT_PCSR |
cd00603 |
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ... |
1323-1445 |
8.31e-04 |
|
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
Pssm-ID: 238337 [Multi-domain] Cd Length: 90 Bit Score: 40.52 E-value: 8.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 1323 PNITFAEPPKSFLSGGRVLRVHGYNLDVVQKPkIRVTVspserrrrgvgrwrriipdsecpEDSLCSIQQfeepclVNSS 1402
Cdd:cd00603 1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPR-VRVTV-----------------------GGVPCKVLN------VSST 50
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 2043825702 1403 YlILCKTPAINlLLRSVRIKLEFILDNLSFDFNSlhPMPFSYE 1445
Cdd:cd00603 51 E-IVCRTPAAA-TPGEGPVEVTVDGANVSARVLS--NTTFTYV 89
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
693-906 |
1.74e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.62 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 693 VYPSSAAPLTkSSTTAPTTAPKPVTtpvlvGPSTVPHTEAIHVTPSAASEPTttteptqspgyTPLTLSTEAASLQAATE 772
Cdd:PHA03307 42 QLVSDSAELA-AVTVVAGAAACDRF-----EPPTGPPPGPGTEAPANESRST-----------PTWSLSTLAPASPAREG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 773 SPLPlPADKPAVTVPQTTSPAASvlsNPSKNMDHIALPTEGPATAQDAWHTDPPTTLGG--------SPLHTSPVAAVTP 844
Cdd:PHA03307 105 SPTP-PGPSSPDPPPPTPPPASP---PPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPaavasdaaSSRQAALPLSSPE 180
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2043825702 845 SPqVTSFKWPPSPFPTTEALTSAISSPQTPSQVPGSPVVSDDAPGLPGTELPVSGLPTSAPP 906
Cdd:PHA03307 181 ET-ARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSS 241
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
764-902 |
2.94e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 42.67 E-value: 2.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 764 AASLQAATESPLPLPADkPAVTVPQTTSPAASvlsnpsknmdhiALPTEGPATAQDawhtdPPTTLGGSPLHTSPVAAVT 843
Cdd:PRK07764 398 APSAAAAAPAAAPAPAA-AAPAAAAAPAPAAA------------PQPAPAPAPAPA-----PPSPAGNAPAGGAPSPPPA 459
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2043825702 844 PSPqvtsfkwPPSPFPTTEALTSAISSPQTPSQVPGSPVVSDDAPGLPGTELPVSGLPT 902
Cdd:PRK07764 460 AAP-------SAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAAT 511
|
|
| PRK10856 |
PRK10856 |
cytoskeleton protein RodZ; |
698-787 |
3.08e-03 |
|
cytoskeleton protein RodZ;
Pssm-ID: 236776 [Multi-domain] Cd Length: 331 Bit Score: 42.32 E-value: 3.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 698 AAPLTKSSTTAPTTAPKPVTTPvlvgPSTVPHTEAIHVTPSAASEPTTTTEPTQSPGYTPL-TLSTEAASLQAATESPLP 776
Cdd:PRK10856 161 SVPLDTSTTTDPATTPAPAAPV----DTTPTNSQTPAVATAPAPAVDPQQNAVVAPSQANVdTAATPAPAAPATPDGAAP 236
|
90
....*....|.
gi 2043825702 777 LPADKPAVTVP 787
Cdd:PRK10856 237 LPTDQAGVSTP 247
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
695-822 |
3.56e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 42.39 E-value: 3.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 695 PSSAAPLTKSSTTAPTTAPkPVTTPVLVGPSTVPHTEAIHVTPSAASEPTTTTEPTQSPGYTPLTLSTEAASLQAATESP 774
Cdd:PRK14951 366 PAAAAEAAAPAEKKTPARP-EAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAA 444
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 2043825702 775 LPLPADKPAVTVPQTTSPAASVLSNPSKNMDHIALPTEGPATAQ------DAWH 822
Cdd:PRK14951 445 VALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLtpteegDVWH 498
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
698-889 |
4.87e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 42.14 E-value: 4.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 698 AAPLTKSSTTAPTTAPKP-VTTPVLVGPSTVPHTEAIHVTPSAASEPTTTTEPTQSPGYTPLTLSTEAASLQAATEsplp 776
Cdd:PRK07003 366 GAPGGGVPARVAGAVPAPgARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDD---- 441
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 777 lPADKPAvTVPQTTSPAASVLSNPSknmDHIALPTEGPATAQDAWHTDPPttlggsplhTSPVAAVTPSPQVTSFKWPPS 856
Cdd:PRK07003 442 -AADGDA-PVPAKANARASADSRCD---ERDAQPPADSGSASAPASDAPP---------DAAFEPAPRAAAPSAATPAAV 507
|
170 180 190
....*....|....*....|....*....|...
gi 2043825702 857 PFPTTEALTSAISSPQTPSqvPGSPVVSDDAPG 889
Cdd:PRK07003 508 PDARAPAAASREDAPAAAA--PPAPEARPPTPA 538
|
|
| PSI |
smart00423 |
domain found in Plexins, Semaphorins and Integrins; |
650-677 |
4.94e-03 |
|
domain found in Plexins, Semaphorins and Integrins;
Pssm-ID: 214655 [Multi-domain] Cd Length: 47 Bit Score: 36.75 E-value: 4.94e-03
10 20
....*....|....*....|....*....
gi 2043825702 650 CQKCVSSLWG-CNWCIQQHLCTHKAACEE 677
Cdd:smart00423 8 CSECLLARDPyCAWCSSQGRCTSGERCDS 36
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
722-906 |
6.24e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 41.90 E-value: 6.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 722 VGPSTVPHTEAIHVTPSAASEPTTTTEPTQSPGYTPltlsTEAASLQAATESPLPLPADKPAVTVPQTTSPAASVLSNPS 801
Cdd:PRK07764 588 VGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAA----PAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDAS 663
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 802 KNMDHIALPTEGPATAQDAWHTDPPTTLGGsplhtSPVAAVTPSPQVTsfkWPPSPFPTTEALTSAISSPQTPSQVPGSP 881
Cdd:PRK07764 664 DGGDGWPAKAGGAAPAAPPPAPAPAAPAAP-----AGAAPAQPAPAPA---ATPPAGQADDPAAQPPQAAQGASAPSPAA 735
|
170 180
....*....|....*....|....*
gi 2043825702 882 VVSDDAPGLPGTELPVSGLPTSAPP 906
Cdd:PRK07764 736 DDPVPLPPEPDDPPDPAGAPAQPPP 760
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
694-906 |
6.52e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 41.70 E-value: 6.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 694 YPSSAAPLTKSSTTAPTTAPKPVTTPVLVGPSTVPHTEAIHVTPSAASEPTTTTEPTQSPGYTPLTLSTEAASLQAA--- 770
Cdd:PHA03307 169 SRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSgcg 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 771 ----TESPLPLPAdkpavTVPQTTSPAASVLSNPSknmdhialptegPATAQDAWHTDPPTTLGGSPLHTSPVAAVTPSP 846
Cdd:PHA03307 249 wgpeNECPLPRPA-----PITLPTRIWEASGWNGP------------SSRPGPASSSSSPRERSPSPSPSSPGSGPAPSS 311
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2043825702 847 QVTSFKWPPSPFPTTEALTSAISSPQTPSQVPGSPVVSDDAPGLPGTELPVSGLPTSAPP 906
Cdd:PHA03307 312 PRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRP 371
|
|
| PSI |
pfam01437 |
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ... |
650-675 |
8.28e-03 |
|
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).
Pssm-ID: 396154 [Multi-domain] Cd Length: 52 Bit Score: 36.53 E-value: 8.28e-03
10 20
....*....|....*....|....*..
gi 2043825702 650 CQKCVSSL-WGCNWCIQQHLCTHKAAC 675
Cdd:pfam01437 8 CSSCLAARdPYCGWCSSEGRCVRRSAC 34
|
|
| |
