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Conserved domains on  [gi|1753122716|ref|XP_030887228|]
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MAPK-interacting and spindle-stabilizing protein-like [Leptonychotes weddellii]

Protein Classification

MISS domain-containing protein( domain architecture ID 12175024)

MISS domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
5-241 1.62e-58

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


:

Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 185.57  E-value: 1.62e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753122716   5 FSLADALPEHSPAKTSAVSNTKPGQPPQGWPSSNPWNNPSAPPSVPSGLPPSATPSTVPFGPAPTGMYPSVPPTGPPPGP 84
Cdd:pfam15822   1 FSLADALPEQSPAKTSAVSNPKPGQPPQGWPGSNPWNNPSAPPAVPSGLPPSTAPSTVPFGPAPTGMYPSIPLTGPSPGP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753122716  85 PAPFPPSGPSCPPPGGPYPAPTVPGPGPTGPYPTPNMPFPELPRPYGAPTDPAAAGPLGPWGSMSSGPWAPGMGGQYPTP 164
Cdd:pfam15822  81 PAPFPPSGPSCPPPGGPYPAPTVPGPGPIGPYPTPNMPFPELPRPYGAPTDPAAAAPSGPWGSMSSGPWAPGMGGQYPAP 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1753122716 165 NMPYPSPGPYPAPPPQAPGAAPPV-PWGTVPPGAWGPPAPYPAPAGSYPTPGLYPTPNNPFQVPSGPSGAPPMPGGPH 241
Cdd:pfam15822 161 NMPYPSPGPYPAVPPPQSPGAAPPvPWGTVPPGPWGPPAPYPDPTGSYPMPGLYPTPNNPFQVPSGPSGAPPMPGGPH 238
 
Name Accession Description Interval E-value
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
5-241 1.62e-58

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 185.57  E-value: 1.62e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753122716   5 FSLADALPEHSPAKTSAVSNTKPGQPPQGWPSSNPWNNPSAPPSVPSGLPPSATPSTVPFGPAPTGMYPSVPPTGPPPGP 84
Cdd:pfam15822   1 FSLADALPEQSPAKTSAVSNPKPGQPPQGWPGSNPWNNPSAPPAVPSGLPPSTAPSTVPFGPAPTGMYPSIPLTGPSPGP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753122716  85 PAPFPPSGPSCPPPGGPYPAPTVPGPGPTGPYPTPNMPFPELPRPYGAPTDPAAAGPLGPWGSMSSGPWAPGMGGQYPTP 164
Cdd:pfam15822  81 PAPFPPSGPSCPPPGGPYPAPTVPGPGPIGPYPTPNMPFPELPRPYGAPTDPAAAAPSGPWGSMSSGPWAPGMGGQYPAP 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1753122716 165 NMPYPSPGPYPAPPPQAPGAAPPV-PWGTVPPGAWGPPAPYPAPAGSYPTPGLYPTPNNPFQVPSGPSGAPPMPGGPH 241
Cdd:pfam15822 161 NMPYPSPGPYPAVPPPQSPGAAPPvPWGTVPPGPWGPPAPYPDPTGSYPMPGLYPTPNNPFQVPSGPSGAPPMPGGPH 238
 
Name Accession Description Interval E-value
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
5-241 1.62e-58

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 185.57  E-value: 1.62e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753122716   5 FSLADALPEHSPAKTSAVSNTKPGQPPQGWPSSNPWNNPSAPPSVPSGLPPSATPSTVPFGPAPTGMYPSVPPTGPPPGP 84
Cdd:pfam15822   1 FSLADALPEQSPAKTSAVSNPKPGQPPQGWPGSNPWNNPSAPPAVPSGLPPSTAPSTVPFGPAPTGMYPSIPLTGPSPGP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753122716  85 PAPFPPSGPSCPPPGGPYPAPTVPGPGPTGPYPTPNMPFPELPRPYGAPTDPAAAGPLGPWGSMSSGPWAPGMGGQYPTP 164
Cdd:pfam15822  81 PAPFPPSGPSCPPPGGPYPAPTVPGPGPIGPYPTPNMPFPELPRPYGAPTDPAAAAPSGPWGSMSSGPWAPGMGGQYPAP 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1753122716 165 NMPYPSPGPYPAPPPQAPGAAPPV-PWGTVPPGAWGPPAPYPAPAGSYPTPGLYPTPNNPFQVPSGPSGAPPMPGGPH 241
Cdd:pfam15822 161 NMPYPSPGPYPAVPPPQSPGAAPPvPWGTVPPGPWGPPAPYPDPTGSYPMPGLYPTPNNPFQVPSGPSGAPPMPGGPH 238
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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