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Conserved domains on  [gi|1776127484|ref|XP_031457472|]
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adenylate kinase isoenzyme 1 isoform X1 [Phasianus colchicus]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11492279)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 75-262 2.46e-137

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


:

Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 384.17  E-value: 2.46e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  75 KHHKIIFVVGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMLAKAD 154
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 155 TSKGFLIDGYPREVKQGEEFEKKIGPPTLLLYVDAGKETMVKRLLKRGETSGRVDDNEETIKKRLETYYKATEPVITFYK 234
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 1776127484 235 GRGIVRQLNAEGTVDEVFQQVCSYLDKL 262
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
TFP super family cl45932
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 34-65 8.61e-03

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


The actual alignment was detected with superfamily member cd23563:

Pssm-ID: 480272  Cd Length: 88  Bit Score: 34.74  E-value: 8.61e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1776127484  34 QPHSCQGTVGSQCLSmSSFNVLDCPGDRDGCF 65
Cdd:cd23563     5 ECYSCVGNSRGACSP-SNAPVVRCYGAYSGCF 35
 
Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 75-262 2.46e-137

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 384.17  E-value: 2.46e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  75 KHHKIIFVVGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMLAKAD 154
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 155 TSKGFLIDGYPREVKQGEEFEKKIGPPTLLLYVDAGKETMVKRLLKRGETSGRVDDNEETIKKRLETYYKATEPVITFYK 234
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 1776127484 235 GRGIVRQLNAEGTVDEVFQQVCSYLDKL 262
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 79-251 1.64e-78

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 235.21  E-value: 1.64e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  79 IIFVVGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAmLAKADTSKG 158
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 159 FLIDGYPREVKQGEEFEKKI---GPPTLLLYVDAGKETMVKRLLKRGET-------------------SGRVDDNEETIK 216
Cdd:cd01428    80 FILDGFPRTVDQAEALDELLdegIKPDKVIELDVPDEVLIERILGRRICpvsgrvyhlgkddvtgeplSQRSDDNEETIK 159

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1776127484 217 KRLETYYKATEPVITFYKGRGIVRQLNAEGTVDEV 251
Cdd:cd01428   160 KRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
ADK pfam00406
Adenylate kinase;
82-234 5.74e-72

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 218.33  E-value: 5.74e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  82 VVGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMlAKADTSKGFLI 161
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERL-EQNDCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 162 DGYPREVKQGEEFE---KKIGPPTLLLYVDAGKETMVKRLLKRGET---------------------------SGRVDDN 211
Cdd:pfam00406  80 DGFPRTVPQAEALEellERGIKLDYVIEFDVPDEVLVERLTGRRIHpnsgrsyhlefnppkvpgkddvtgeplVQRSDDN 159

                         170       180
                  ....*....|....*....|...
gi 1776127484 212 EETIKKRLETYYKATEPVITFYK 234
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYK 182
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 78-259 7.53e-71

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 216.53  E-value: 7.53e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  78 KIIFVvGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAmLAKADTSK 157
Cdd:COG0563     2 RIILL-GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKER-LAQPDCAN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 158 GFLIDGYPREVKQGEEFEK---KIG-PPTLLLYVDAGKETMVKRLLKR---------------------------GETSG 206
Cdd:COG0563    80 GFILDGFPRTVAQAEALDEllaELGiKLDAVIELDVDDEELVERLSGRrvcpncgatyhvkfnppkvegvcdkcgGELVQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1776127484 207 RVDDNEETIKKRLETYYKATEPVITFYKGRGIVRQLNAEGTVDEVFQQVCSYL 259
Cdd:COG0563   160 RADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
adk PRK00279
adenylate kinase; Reviewed
 78-262 5.74e-70

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 214.24  E-value: 5.74e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  78 KIIFVvGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAmLAKADTSK 157
Cdd:PRK00279    2 RLILL-GPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKER-LAQPDCKN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 158 GFLIDGYPREVKQGEEFE---KKIGPP-TLLLYVDAGKETMVKRLLKR---------------------------GETSG 206
Cdd:PRK00279   80 GFLLDGFPRTIPQAEALDemlKELGIKlDAVIEIDVPDEELVERLSGRricpacgrtyhvkfnppkvegkcdvcgEELIQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1776127484 207 RVDDNEETIKKRLETYYKATEPVITFYKGRGIVRQLNAEGTVDEVFQQVCSYLDKL 262
Cdd:PRK00279  160 RADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGKL 215
TFP_LU_ECD_LYPD3_rpt2 cd23563
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ...
 34-65 8.61e-03

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467093  Cd Length: 88  Bit Score: 34.74  E-value: 8.61e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1776127484  34 QPHSCQGTVGSQCLSmSSFNVLDCPGDRDGCF 65
Cdd:cd23563     5 ECYSCVGNSRGACSP-SNAPVVRCYGAYSGCF 35
 
Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 75-262 2.46e-137

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 384.17  E-value: 2.46e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  75 KHHKIIFVVGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMLAKAD 154
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 155 TSKGFLIDGYPREVKQGEEFEKKIGPPTLLLYVDAGKETMVKRLLKRGETSGRVDDNEETIKKRLETYYKATEPVITFYK 234
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 1776127484 235 GRGIVRQLNAEGTVDEVFQQVCSYLDKL 262
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 79-251 1.64e-78

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 235.21  E-value: 1.64e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  79 IIFVVGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAmLAKADTSKG 158
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 159 FLIDGYPREVKQGEEFEKKI---GPPTLLLYVDAGKETMVKRLLKRGET-------------------SGRVDDNEETIK 216
Cdd:cd01428    80 FILDGFPRTVDQAEALDELLdegIKPDKVIELDVPDEVLIERILGRRICpvsgrvyhlgkddvtgeplSQRSDDNEETIK 159

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1776127484 217 KRLETYYKATEPVITFYKGRGIVRQLNAEGTVDEV 251
Cdd:cd01428   160 KRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
ADK pfam00406
Adenylate kinase;
82-234 5.74e-72

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 218.33  E-value: 5.74e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  82 VVGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMlAKADTSKGFLI 161
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERL-EQNDCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 162 DGYPREVKQGEEFE---KKIGPPTLLLYVDAGKETMVKRLLKRGET---------------------------SGRVDDN 211
Cdd:pfam00406  80 DGFPRTVPQAEALEellERGIKLDYVIEFDVPDEVLVERLTGRRIHpnsgrsyhlefnppkvpgkddvtgeplVQRSDDN 159

                         170       180
                  ....*....|....*....|...
gi 1776127484 212 EETIKKRLETYYKATEPVITFYK 234
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYK 182
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 78-259 7.53e-71

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 216.53  E-value: 7.53e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  78 KIIFVvGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAmLAKADTSK 157
Cdd:COG0563     2 RIILL-GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKER-LAQPDCAN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 158 GFLIDGYPREVKQGEEFEK---KIG-PPTLLLYVDAGKETMVKRLLKR---------------------------GETSG 206
Cdd:COG0563    80 GFILDGFPRTVAQAEALDEllaELGiKLDAVIELDVDDEELVERLSGRrvcpncgatyhvkfnppkvegvcdkcgGELVQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1776127484 207 RVDDNEETIKKRLETYYKATEPVITFYKGRGIVRQLNAEGTVDEVFQQVCSYL 259
Cdd:COG0563   160 RADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 79-255 9.78e-71

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 215.31  E-value: 9.78e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  79 IIFVVGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVS-SGSERGKKLQAIMEKGELVPLDTVLDMLRDAMLAkADTSK 157
Cdd:TIGR01359   1 VVFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKrEGSENGSLIESYIKEGKIVPSEVTVELLKKAIQE-DGSSK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 158 GFLIDGYPREVKQGEEFEKKIGP---PTLLLYVDAGKETMVKRLLKRGETSGRVDDNEETIKKRLETYYKATEPVITFYK 234
Cdd:TIGR01359  80 KFLIDGFPRNEENLEAWEKLMDNkvnFKFVLFFDCPEETMIKRLLKRGQTSGRVDDNIETLKKRFRTYNEETLPIIEHFE 159

                         170       180
                  ....*....|....*....|.
gi 1776127484 235 GRGIVRQLNAEGTVDEVFQQV 255
Cdd:TIGR01359 160 NKGKVKEINAEGSVEEVFEDV 180
adk PRK00279
adenylate kinase; Reviewed
 78-262 5.74e-70

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 214.24  E-value: 5.74e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  78 KIIFVvGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAmLAKADTSK 157
Cdd:PRK00279    2 RLILL-GPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKER-LAQPDCKN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 158 GFLIDGYPREVKQGEEFE---KKIGPP-TLLLYVDAGKETMVKRLLKR---------------------------GETSG 206
Cdd:PRK00279   80 GFLLDGFPRTIPQAEALDemlKELGIKlDAVIEIDVPDEELVERLSGRricpacgrtyhvkfnppkvegkcdvcgEELIQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1776127484 207 RVDDNEETIKKRLETYYKATEPVITFYKGRGIVRQLNAEGTVDEVFQQVCSYLDKL 262
Cdd:PRK00279  160 RADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGKL 215
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 78-260 3.62e-60

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 189.37  E-value: 3.62e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  78 KIIFVvGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMLAKADTSK 157
Cdd:TIGR01351   1 RLVLL-GPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNEN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 158 GFLIDGYPREVKQGEEFEKKI-GPPTLLLYVDAGKETMVKRLLKRG--ETSGRV-------------------------D 209
Cdd:TIGR01351  80 GFILDGFPRTLSQAEALDALLeEPIDAVIELDVPDEELVERLSGRRicPSCGRVyhlkfnppkvpgcddctgellvqreD 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1776127484 210 DNEETIKKRLETYYKATEPVITFYKGRGIVRQLNAEGTVDEVFQQVCSYLD 260
Cdd:TIGR01351 160 DTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRILEALK 210
PLN02200 PLN02200
adenylate kinase family protein
 79-255 4.42e-55

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 177.01  E-value: 4.42e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  79 IIFVVGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMlAKADTSKg 158
Cdd:PLN02200   45 ITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEM-ESSDNNK- 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 159 FLIDGYPREVKQGEEFEKKIG-PPTLLLYVDAGKETMVKRLLKRGEtsGRVDDNEETIKKRLETYYKATEPVITFYKGRG 237
Cdd:PLN02200  123 FLIDGFPRTEENRIAFERIIGaEPNVVLFFDCPEEEMVKRVLNRNQ--GRVDDNIDTIKKRLKVFNALNLPVIDYYSKKG 200

                         170
                  ....*....|....*...
gi 1776127484 238 IVRQLNAEGTVDEVFQQV 255
Cdd:PLN02200  201 KLYTINAVGTVDEIFEQV 218
PRK14531 PRK14531
adenylate kinase; Provisional
 77-260 1.79e-50

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 163.44  E-value: 1.79e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  77 HKIIFVvGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMlaKADTS 156
Cdd:PRK14531    3 QRLLFL-GPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQL--KALNS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 157 KGFLIDGYPREVKQGEEFEKKIG----PPTLLLYVDAGKETMVKRLLKRgetsGRVDDNEETIKKRLETYYKATEPVITF 232
Cdd:PRK14531   80 GGWLLDGFPRTVAQAEALEPLLEelkqPIEAVVLLELDDAVLIERLLAR----GRADDNEAVIRNRLEVYREKTAPLIDH 155

                         170       180
                  ....*....|....*....|....*...
gi 1776127484 233 YKGRGIVRQLNAEGTVDEVFQQVCSYLD 260
Cdd:PRK14531  156 YRQRGLLQSVEAQGSIEAITERIEKVLA 183
PRK14527 PRK14527
adenylate kinase; Provisional
 78-259 4.73e-50

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 162.65  E-value: 4.73e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  78 KIIFVVGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAmLAKADTSK 157
Cdd:PRK14527    7 KVVIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDE-LAGMEPVR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 158 gFLIDGYPREVKQGEEFEK---KIGPPTL-LLYVDAGKETMVKRLLKRGETSGRVDDNEETIKKRLETYYKATEPVITFY 233
Cdd:PRK14527   86 -VIFDGFPRTLAQAEALDRlleELGARLLaVVLLEVPDEELIRRIVERARQEGRSDDNEETVRRRQQVYREQTQPLVDYY 164

                         170       180
                  ....*....|....*....|....*.
gi 1776127484 234 KGRGIVRQLNAEGTVDEVFQQVCSYL 259
Cdd:PRK14527  165 EARGHLKRVDGLGTPDEVYARILKAL 190
PRK14532 PRK14532
adenylate kinase; Provisional
 79-251 2.85e-46

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 153.05  E-value: 2.85e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  79 IIFvvGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDaMLAKADTSKG 158
Cdd:PRK14532    4 ILF--GPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEE-RLPEAEAAGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 159 FLIDGYPREVKQGEEFEK-------KIGpPTLLLYVDagKETMVKRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIT 231
Cdd:PRK14532   81 AIFDGFPRTVAQAEALDKmlasrgqKID-VVIRLKVD--DEALIERIVKRFEEQGRPDDNPEVFVTRLDAYNAQTAPLLP 157

                         170       180
                  ....*....|....*....|
gi 1776127484 232 FYKGRGIVRQLNAEGTVDEV 251
Cdd:PRK14532  158 YYAGQGKLTEVDGMGSIEAV 177
PRK14528 PRK14528
adenylate kinase; Provisional
 78-251 3.18e-46

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 152.86  E-value: 3.18e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  78 KIIFVvGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDaMLAKADTSK 157
Cdd:PRK14528    3 NIIFM-GPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKD-RIREADCKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 158 GFLIDGYPREVKQGE---EFEKKIGPPT-LLLYVDAGKETMVKRLLKRGETSGRVDDNEETIKKRLETYYKATEPVITFY 233
Cdd:PRK14528   81 GFLLDGFPRTVEQADaldALLKNEGKSIdKAINLEVPDGELLKRLLGRAEIEGRADDNEATIKNRLDNYNKKTLPLLDFY 160

                         170
                  ....*....|....*...
gi 1776127484 234 KGRGIVRQLNAEGTVDEV 251
Cdd:PRK14528  161 AAQKKLSQVNGVGSLEEV 178
AAA_17 pfam13207
AAA domain;
83-216 1.30e-44

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 147.00  E-value: 1.30e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  83 VGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSerGKKLQAIMEKGELVPLDTVLDMLRDAmLAKADTSKGFLID 162
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAER-IAEEAGEGGVIVD 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 163 GYPREVKQGEEFEK------KIGPPTLLLYVDAGKETMVKRLLKRgETSGRVDDNEETIK 216
Cdd:pfam13207  78 GHPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKD-RTRGRDDDSEEEIR 136
adk PRK02496
adenylate kinase; Provisional
 78-251 3.78e-44

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 147.59  E-value: 3.78e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  78 KIIFVvGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDaMLAKADTSK 157
Cdd:PRK02496    3 RLIFL-GPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQE-RLQQPDAAN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 158 GFLIDGYPREVKQGEEFEK---KIGPPT-LLLYVDAGKETMVKRLLKRgetsGRVDDNEETIKKRLETYYKATEPVITFY 233
Cdd:PRK02496   81 GWILDGFPRKVTQAAFLDEllqEIGQSGeRVVNLDVPDDVVVERLLAR----GRKDDTEEVIRRRLEVYREQTAPLIDYY 156

                         170
                  ....*....|....*...
gi 1776127484 234 KGRGIVRQLNAEGTVDEV 251
Cdd:PRK02496  157 RDRQKLLTIDGNQSVEAV 174
PRK14530 PRK14530
adenylate kinase; Provisional
 77-260 1.71e-39

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 136.46  E-value: 1.71e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  77 HKIIFVVGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRA---------EVSSGSERgkklqAIMEKGELVPlDTVLDMLRD 147
Cdd:PRK14530    3 QPRILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRAnkqmdisdmDTEYDTPG-----EYMDAGELVP-DAVVNEIVE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 148 AMLAKADtskGFLIDGYPREVKQGEEFEKkIGPPTLLLYVDAGKETMVKRLLKR-------------------------- 201
Cdd:PRK14530   77 EALSDAD---GFVLDGYPRNLEQAEYLES-ITDLDVVLYLDVSEEELVDRLTGRrvcpdcganyhvefnqpeeegvcdec 152

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 202 -GETSGRVDDNEETIKKRLETYYKATEPVITFYKGRGIVRQLNAEGTVDEVFQQVCSYLD 260
Cdd:PRK14530  153 gGELIQRDDDTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTPDEVWADIQDAID 212
PLN02842 PLN02842
nucleotide kinase
 82-262 3.33e-38

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 139.61  E-value: 3.33e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  82 VVGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMLAKADTSKGFLI 161
Cdd:PLN02842    2 ISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 162 DGYPREVKQGEEFEKKIGPPTLLLYVDAGKETMVKRLLKR-------------------GETSGRV----DDNEETIKKR 218
Cdd:PLN02842   82 DGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRrldpvtgkiyhiknfppesEEIKARLitrpDDTEEKVKAR 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1776127484 219 LETYYKATEPVITFYKgrGIVRQLNAEGTVDEVFQQVCSYLDKL 262
Cdd:PLN02842  162 LQIYKKNAEAILSTYS--DIMVKIDGNRPKEVVFEEISSLLSQI 203
PLN02674 PLN02674
adenylate kinase
 75-255 9.57e-33

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 119.60  E-value: 9.57e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  75 KHHKIIFVVGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMlAKAD 154
Cdd:PLN02674   29 KPDKRLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAM-KKPS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 155 TSKGFLIDGYPREV-----------KQGEEFEK------------------------------KIGPPTLLLYVDAGKET 193
Cdd:PLN02674  108 CQKGFILDGFPRTVvqaqkldemlaKQGAKIDKvlnfaiddaileeritgrwihpssgrtyhtKFAPPKVPGVDDVTGEP 187

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1776127484 194 MVKrllkrgetsgRVDDNEETIKKRLETYYKATEPVITFYKGRGIVRQLNAEGTVDEVFQQV 255
Cdd:PLN02674  188 LIQ----------RKDDTAAVLKSRLEAFHKQTEPVIDYYAKKGVVANLHAEKPPKEVTAEV 239
PRK13808 PRK13808
adenylate kinase; Provisional
 80-262 1.04e-32

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 121.92  E-value: 1.04e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  80 IFVVGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDaMLAKADTSKGF 159
Cdd:PRK13808    3 LILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISD-RIEQPDAANGF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 160 LIDGYPREVKQGEEF-----EKKIGPPTLL-LYVDAGK-----ETMVKRLLKRGETSgRVDDNEETIKKRLETYYKATEP 228
Cdd:PRK13808   82 ILDGFPRTVPQAEALdallkDKQLKLDAVVeLRVNEGAllarvETRVAEMRARGEEV-RADDTPEVLAKRLASYRAQTEP 160

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1776127484 229 VITFYKGRGIVRQLNAEGTVDEVFQQVCSYLDKL 262
Cdd:PRK13808  161 LVHYYSEKRKLLTVDGMMTIDEVTREIGRVLAAV 194
PLN02459 PLN02459
probable adenylate kinase
 84-250 8.06e-28

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 107.24  E-value: 8.06e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  84 GGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMLA-KADTSKGFLID 162
Cdd:PLN02459   36 GCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAgEEEGESGFILD 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 163 GYPREVKQGEEFEkKIGPPTLLLYVDAGKETMVKRLLKR---GETSG--------------------------------- 206
Cdd:PLN02459  116 GFPRTVRQAEILE-GVTDIDLVVNLKLREEVLVEKCLGRricSECGKnfnvadidlkgedgrpgivmppllpppecaskl 194

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1776127484 207 --RVDDNEETIKKRLETYYKATEPVITFYKGRGIVRQLNAEGTVDE 250
Cdd:PLN02459  195 itRADDTEEVVKARLRVYKEESQPVEDFYRKRGKLLEFELPGGIPE 240
PRK14526 PRK14526
adenylate kinase; Provisional
 78-261 1.65e-27

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 105.32  E-value: 1.65e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  78 KIIFVvGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMLAkADTSK 157
Cdd:PRK14526    2 KLVFL-GPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINT-IKNND 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 158 GFLIDGYPREVKQGEEFEKKIgPPTLLLYVDAGKETMVKRLLKR---------------------------GETSGRVDD 210
Cdd:PRK14526   80 NFILDGFPRNINQAKALDKFL-PNIKIINFLIDEELLIKRLSGRrickscnnifniytlptkekgicdvckGDLYQRKDD 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1776127484 211 NEETIKKRLETYYKATEPVITFYKGRGIVRQLNAEGTVDEVFQQVCSYLDK 261
Cdd:PRK14526  159 KEESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKDIDEVKKKLIEIISK 209
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 78-238 8.72e-25

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 98.33  E-value: 8.72e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  78 KIIFVvGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMlAKA--DT 155
Cdd:PTZ00088    8 KIVLF-GAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEI-AKVtdDC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 156 SKGFLIDGYPREVKQGEEFeKKIGPPTLLLYVDAGKETMVKRLLKR----------------------------GETSG- 206
Cdd:PTZ00088   86 FKGFILDGFPRNLKQCKEL-GKITNIDLFVNIYLPRNILIKKLLGRricntcnrnfniahirsdpydmppilppADCEGc 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1776127484 207 --------RVDDNEETIKKRLETYYKATEPVITFYKGRGI 238
Cdd:PTZ00088  165 kgnpklqkRSDDTEEIVAHRLNTYESTNSPIIQFFKNENC 204
PRK14529 PRK14529
adenylate kinase; Provisional
 80-260 5.72e-21

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 88.24  E-value: 5.72e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  80 IFVVGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMlaKADTSKGF 159
Cdd:PRK14529    3 ILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETL--KQDGKNGW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 160 LIDGYPREVKQGEEFEKKIGPPTLLL-YV--------DAGKETMVKRLLKR------------------------GETSG 206
Cdd:PRK14529   81 LLDGFPRNKVQAEKLWEALQKEGMKLdYVieillpreVAKNRIMGRRLCKNdnnhpnnifidaikpdgdvcrvcgGELST 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1776127484 207 RVDD-NEETIKKRLETYYKA---TEPVITFYK-----GRGIVRQLNAEGTVDEVFQQVCSYLD 260
Cdd:PRK14529  161 RADDqDEEAINKRHDIYYDTetgTLAAAYFFKdlaakGSTKYIELDGEGSIDEIKETLLKQLS 223
PRK01184 PRK01184
flagellar hook-basal body complex protein FliE;
78-218 6.96e-08

flagellar hook-basal body complex protein FliE;


Pssm-ID: 234914 [Multi-domain]  Cd Length: 184  Bit Score: 51.10  E-value: 6.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  78 KIIFVVGGPGSGKGtQCEKIVHKYGYTHLSTGDLLRAEVssgSERGkklqaimekgeLVPLDTVLDM----LRD------ 147
Cdd:PRK01184    2 KIIGVVGMPGSGKG-EFSKIAREMGIPVVVMGDVIREEV---KKRG-----------LEPTDENIGKvaidLRKelgmda 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1776127484 148 -AMLA----KADTSKGFLIDGYpREVKQGEEFEKKIGPPTLLLYVDAGKETMVKRLLKRgetsGRVDDNE--ETIKKR 218
Cdd:PRK01184   67 vAKRTvpkiREKGDEVVVIDGV-RGDAEVEYFRKEFPEDFILIAIHAPPEVRFERLKKR----GRSDDPKswEELEER 139
TMPK cd01672
Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the ...
 78-261 1.89e-07

Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step in either de novo or salvage biosynthesis of thymidine triphosphate (TTP).


Pssm-ID: 238835  Cd Length: 200  Bit Score: 50.34  E-value: 1.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  78 KIIFVVGGPGSGKGTQCEKIVH---KYGYTHLSTGDLlraevsSGSERGKKLQAIMEKGELVPLDTVLDML-----RDAM 149
Cdd:cd01672     1 MFIVFEGIDGAGKTTLIELLAErleARGYEVVLTREP------GGTPIGEAIRELLLDPEDEKMDPRAELLlfaadRAQH 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 150 LA---KADTSKGFLI--D----------GYPR-----EVKQGEEFEKKIGPPTLLLYVDAGKETMVKRLLKRGETSGRVD 209
Cdd:cd01672    75 VEeviKPALARGKIVlsDrfvdsslayqGAGRglgeaLIEALNDLATGGLKPDLTILLDIDPEVGLARIEARGRDDRDEQ 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1776127484 210 DNEETIKKRLETYYKatepVITFYKGRGIVrqLNAEGTVDEVFQQVCSYLDK 261
Cdd:cd01672   155 EGLEFHERVREGYLE----LAAQEPERIIV--IDASQPLEEVLAEILKAILE 200
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 80-222 2.26e-07

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 48.85  E-value: 2.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  80 IFVVGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLQAImekGELVPlDTVLDMLRDAMLAKADTskgf 159
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRLLEELGAVRLSSDDERKRLFGEGRPSISYYTDA---TDRTY-ERLHELARIALRAGRPV---- 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1776127484 160 LIDG---YPREVKQGEEFEKKIGPPTLLLYVDAGKETMVKRLLKRGETSG-RVDDNEETIKKRLETY 222
Cdd:pfam13671  74 ILDAtnlRRDERARLLALAREYGVPVRIVVFEAPEEVLRERLAARARAGGdPSDVPEEVLDRQKARF 140
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
79-251 1.74e-06

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 46.83  E-value: 1.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  79 IIFVVGGPGSGKGTQCEKIVHKYGYTHLSTgDLLRAEVssgseRGKKLQAIMEKGELVpldtvlDMLRDAMLAKADT--S 156
Cdd:COG0645     1 LILVCGLPGSGKSTLARALAERLGAVRLRS-DVVRKRL-----FGAGLAPLERSPEAT------ARTYARLLALAREllA 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484 157 KGF--LIDG---YPREVKQGEEFEKKIGPPTLLLYVDAGKETMVKRLLKRGETSGRVDDNEETIKKRLETYykatEPVIT 231
Cdd:COG0645    69 AGRsvILDAtflRRAQREAFRALAEEAGAPFVLIWLDAPEEVLRERLEARNAEGGDSDATWEVLERQLAFE----EPLTE 144

                         170       180
                  ....*....|....*....|
gi 1776127484 232 FYKGRGIVRQLNAEGTVDEV 251
Cdd:COG0645   145 DEGFLLVVDTSGLEEALAAL 164
PRK04182 PRK04182
cytidylate kinase; Provisional
 79-218 6.16e-06

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 45.57  E-value: 6.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  79 IIFVVGGPGSGKGTQCEKIVHKYGYTHLSTGDLLR--AEvssgsERGKKLQAIMEKGELVP-LDTVLD-MLRDAMLAKAD 154
Cdd:PRK04182    2 IITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRelAK-----ERGMSLEEFNKYAEEDPeIDKEIDrRQLEIAEKEDN 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1776127484 155 T---SK--GFLIDGYprevkqgeefekkigpPTLLLYVDAGKETMVKRLLKRGETSgrVDDNEETIKKR 218
Cdd:PRK04182   77 VvleGRlaGWMAKDY----------------ADLKIWLKAPLEVRAERIAEREGIS--VEEALEETIER 127
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 79-122 7.52e-05

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 41.70  E-value: 7.52e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1776127484  79 IIFVVGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSER 122
Cdd:cd02020     1 IIAIDGPAGSGKSTVAKLLAKKLGLPYLDTGGIRTEEVGKLASE 44
pseT PHA02530
polynucleotide kinase; Provisional
 78-225 5.21e-04

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 40.78  E-value: 5.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  78 KIIFVVGGPGSGKGTQCEKIVHK-YGYTHLSTGDL---LRAEVSSGSERGKKlqaimEKGELVpldTVldMLRDAMLAKA 153
Cdd:PHA02530    3 KIILTVGVPGSGKSTWAREFAAKnPKAVNVNRDDLrqsLFGHGEWGEYKFTK-----EKEDLV---TK--AQEAAALAAL 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1776127484 154 DTSKGFLIDG---YPREVKQGEEFEKKIGPPTLLLYVDAGKETMVKRLLKRGETSGRVDdneetIKKRLETYYKA 225
Cdd:PHA02530   73 KSGKSVIISDtnlNPERRRKWKELAKELGAEFEEKVFDVPVEELVKRNRKRGERAVPED-----VLRSMFKQMKE 142
AAA_18 pfam13238
AAA domain;
80-213 7.06e-03

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 35.87  E-value: 7.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776127484  80 IFVVGGPGSGKGTQCEKIVHKYGY----THLSTGDLLRAEVSSGSERGKKLQAIMekgelvpLDTVLDMLRDAmlAKADT 155
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGFgdnvRDLALENGLVLGDDPETRESKRLDEDK-------LDRLLDLLEEN--AALEE 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1776127484 156 SKGFLIDGYPreVKQGEEFEKKIGPptllLYVDAGKETMVKRLLKRGETSGRVDDNEE 213
Cdd:pfam13238  72 GGNLIIDGHL--AELEPERAKDLVG----IVLRASPEELLERLEKRGYEEAKIKENEE 123
NK cd02019
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 79-105 7.11e-03

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


Pssm-ID: 238977 [Multi-domain]  Cd Length: 69  Bit Score: 34.23  E-value: 7.11e-03
                          10        20
                  ....*....|....*....|....*..
gi 1776127484  79 IIFVVGGPGSGKGTQCEKIVHKYGYTH 105
Cdd:cd02019     1 IIAITGGSGSGKSTVAKKLAEQLGGRS 27
TFP_LU_ECD_LYPD3_rpt2 cd23563
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ...
 34-65 8.61e-03

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467093  Cd Length: 88  Bit Score: 34.74  E-value: 8.61e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1776127484  34 QPHSCQGTVGSQCLSmSSFNVLDCPGDRDGCF 65
Cdd:cd23563     5 ECYSCVGNSRGACSP-SNAPVVRCYGAYSGCF 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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