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Conserved domains on  [gi|1810767034|ref|XP_032301200|]
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protocadherin-15 isoform X1 [Coturnix japonica]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ECD pfam18432
Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be ...
 36-145 7.29e-69

Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be found at the N-terminal region of Protocadherin 15 (Pcdh15). Pcdh15 features exceptionally long extracellular domains containing 11 ECs. These repeats are structurally similar, but not identical in sequence, often featuring linkers with conserved calcium-binding sites that confer mechanical strength to them.


:

Pssm-ID: 408229  Cd Length: 110  Bit Score: 226.90  E-value: 7.29e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034   36 DCKLARTGPPATIVPIDEESRNGTILVDNMLIKGTAAGPDPTIELTLKDNVDYWVILDPISQRLYLNSTGRVLDRDPPMS 115
Cdd:pfam18432    1 DCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMN 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 1810767034  116 IQSIVVQVQCVNKKVGTIINHEVRIVVRDR 145
Cdd:pfam18432   81 IHSIVVQVQCVNKKVGTVIYHEVRIVVRDR 110
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1050-1145 1.89e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.09  E-value: 1.89e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034 1050 VSESAPKGTVVTVVMA----AALNQTIVYSIVSGNEEDMFAINNKTGVISVKKPLDYEKVTSYELRVQAdslqvvrSNLR 1125
Cdd:cd11304      6 VPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTA-------TDGG 78

                           90       100
                   ....*....|....*....|
gi 1810767034 1126 VPSKSNTAKVFIEVKDENDH 1145
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 828-926 1.27e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.78  E-value: 1.27e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  828 SYAVVVPENLPPGTVFLQIEAKDVDLGSN--VTYRIRTQEALEYFALNKYTGELSLRKSLDYEsfsdTDATFTFLVEAFD 905
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|.
gi 1810767034  906 SKGTMPPGLATVTVTVKDMND 926
Cdd:cd11304     77 GGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 729-820 1.40e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 1.40e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  729 NLSVQEEEA-NAFVGQVRATDPDAGVNGQVHYSLA--NFKNLFRI-TSNGSIYTAVKLNREVRDYYELIVEATDGAVDPR 804
Cdd:cd11304      3 EVSVPENAPpGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1810767034  805 RSTLTLAIKVLDIDDN 820
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 626-718 6.19e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.77  E-value: 6.19e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  626 YSLEVSEAMRTGAILLNLQAFDR---EGDPIRYLIENGDPQQVFNLSQSSGLLALGKPLDRESTDRYILIVTASD-GRPD 701
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDgGGPP 81

                           90
                   ....*....|....*..
gi 1810767034  702 GTSTATVNIVVTDVNDN 718
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 518-614 1.13e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.05  E-value: 1.13e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  518 SYSVKIYTDMGPGDGVIKLTAVDADEGPNGQIVYEILAGDQGD-FIINDRTGLIAIAPGVVLSVGRSYALTVKASDSAPP 596
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1810767034  597 aqRRSSITTVYIEVLPPN 614
Cdd:cd11304     81 --PLSSTATVTITVLDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 157-265 1.83e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.58  E-value: 1.83e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  157 YYVAVNELTPVGTTIFTgFSgnngATDIDDGPNGQIEYVIQYNPNDKTsnrtFDI-PLTlsGAVVLRERLNYEEKTRYFV 235
Cdd:cd11304      2 YEVSVPENAPPGTVVLT-VS----ATDPDSGENGEVTYSIVSGNEDGL----FSIdPST--GEITTAKPLDREEQSSYTL 70

                           90       100       110
                   ....*....|....*....|....*....|
gi 1810767034  236 IVQANDRAQNlheRRTSTTTLTVDVLDGDD 265
Cdd:cd11304     71 TVTATDGGGP---PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 936-1032 2.29e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 2.29e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  936 YRGMVAPDAVKGTVITTVSAEDQDPPgtPASRVRYKVDVVQfpySASIFDVEETSGRVVTRVNLNEEPSTVFKLVVIAYD 1015
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                           90
                   ....*....|....*..
gi 1810767034 1016 DGDPVKFNTTTVEITVL 1032
Cdd:cd11304     77 GGGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 404-510 6.88e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.26  E-value: 6.88e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  404 TYEGFILESSPVGTTIsdsrnltspLQITVLDNDVEETKDPQLHLFLNDYNTFFTV-TQSGItryLTLLQPVDREAQQLY 482
Cdd:cd11304      1 SYEVSVPENAPPGTVV---------LTVSATDPDSGENGEVTYSIVSGNEDGLFSIdPSTGE---ITTAKPLDREEQSSY 68

                           90       100       110
                   ....*....|....*....|....*....|
gi 1810767034  483 TFSMIASDGVQE--STPVTVNIVVIDANDN 510
Cdd:cd11304     69 TLTVTATDGGGPplSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1154-1248 3.62e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.26  E-value: 3.62e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034 1154 YIGGVSEDAKMFSSVLKVKADDKDTGNYSAMQYRLIIPpikDGKEGFVIEAYTGLIKTAMLFKNMRRSYFKFQVIATDDY 1233
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90
                   ....*....|....*
gi 1810767034 1234 GKGLSSKADVLVSVV 1248
Cdd:cd11304     79 GPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 286-394 1.86e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.33  E-value: 1.86e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  286 TYQASLPELTDPAQVnpisVTPpIQAIDQDRNIQPPsdrpgILYSILvgtPEDYPQYFHMNLTTAELTLLKPINRDLHQK 365
Cdd:cd11304      1 SYEVSVPENAPPGTV----VLT-VSATDPDSGENGE-----VTYSIV---SGNEDGLFSIDPSTGEITTAKPLDREEQSS 67

                           90       100
                   ....*....|....*....|....*....
gi 1810767034  366 FDLVIKAEQDNGHPLPAFANLHIEVLDEN 394
Cdd:cd11304     68 YTLTVTATDGGGPPLSSTATVTITVLDVN 96
 
Name Accession Description Interval E-value
ECD pfam18432
Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be ...
 36-145 7.29e-69

Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be found at the N-terminal region of Protocadherin 15 (Pcdh15). Pcdh15 features exceptionally long extracellular domains containing 11 ECs. These repeats are structurally similar, but not identical in sequence, often featuring linkers with conserved calcium-binding sites that confer mechanical strength to them.


Pssm-ID: 408229  Cd Length: 110  Bit Score: 226.90  E-value: 7.29e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034   36 DCKLARTGPPATIVPIDEESRNGTILVDNMLIKGTAAGPDPTIELTLKDNVDYWVILDPISQRLYLNSTGRVLDRDPPMS 115
Cdd:pfam18432    1 DCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMN 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 1810767034  116 IQSIVVQVQCVNKKVGTIINHEVRIVVRDR 145
Cdd:pfam18432   81 IHSIVVQVQCVNKKVGTVIYHEVRIVVRDR 110
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1050-1145 1.89e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.09  E-value: 1.89e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034 1050 VSESAPKGTVVTVVMA----AALNQTIVYSIVSGNEEDMFAINNKTGVISVKKPLDYEKVTSYELRVQAdslqvvrSNLR 1125
Cdd:cd11304      6 VPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTA-------TDGG 78

                           90       100
                   ....*....|....*....|
gi 1810767034 1126 VPSKSNTAKVFIEVKDENDH 1145
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 828-926 1.27e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.78  E-value: 1.27e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  828 SYAVVVPENLPPGTVFLQIEAKDVDLGSN--VTYRIRTQEALEYFALNKYTGELSLRKSLDYEsfsdTDATFTFLVEAFD 905
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|.
gi 1810767034  906 SKGTMPPGLATVTVTVKDMND 926
Cdd:cd11304     77 GGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 729-820 1.40e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 1.40e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  729 NLSVQEEEA-NAFVGQVRATDPDAGVNGQVHYSLA--NFKNLFRI-TSNGSIYTAVKLNREVRDYYELIVEATDGAVDPR 804
Cdd:cd11304      3 EVSVPENAPpGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1810767034  805 RSTLTLAIKVLDIDDN 820
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 626-718 6.19e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.77  E-value: 6.19e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  626 YSLEVSEAMRTGAILLNLQAFDR---EGDPIRYLIENGDPQQVFNLSQSSGLLALGKPLDRESTDRYILIVTASD-GRPD 701
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDgGGPP 81

                           90
                   ....*....|....*..
gi 1810767034  702 GTSTATVNIVVTDVNDN 718
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 745-822 6.16e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.56  E-value: 6.16e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034   745 RATDPDAGVNGQVHYSLA--NFKNLFRITSN-GSIYTAVKLNREVRDYYELIVEATDGAVDPRRSTLTLAIKVLDIDDNS 821
Cdd:smart00112    1 SATDADSGENGKVTYSILsgNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1810767034   822 P 822
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1069-1147 2.73e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 2.73e-20
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1810767034  1069 NQTIVYSIVSGNEEDMFAINNKTGVISVKKPLDYEKVTSYELRVQAdslqvvrSNLRVPSKSNTAKVFIEVKDENDHAP 1147
Cdd:smart00112   10 NGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEA-------TDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
731-815 1.67e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.35  E-value: 1.67e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  731 SVQEEEA-NAFVGQVRATDPDAGVNGQVHYSLA--NFKNLFRI-TSNGSIYTAVKLNREVRDYYELIVEATDGAVDPRRS 806
Cdd:pfam00028    4 SVPENAPvGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIdPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                   ....*....
gi 1810767034  807 TLTLAIKVL 815
Cdd:pfam00028   84 TATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1050-1139 7.84e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.42  E-value: 7.84e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034 1050 VSESAPKGTVVTVVMA----AALNQTIVYSIVSGNEEDMFAINNKTGVISVKKPLDYEKVTSYELRVQAdslqvvrSNLR 1125
Cdd:pfam00028    5 VPENAPVGTEVLTVTAtdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA-------TDSG 77

                           90
                   ....*....|....
gi 1810767034 1126 VPSKSNTAKVFIEV 1139
Cdd:pfam00028   78 GPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 518-614 1.13e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.05  E-value: 1.13e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  518 SYSVKIYTDMGPGDGVIKLTAVDADEGPNGQIVYEILAGDQGD-FIINDRTGLIAIAPGVVLSVGRSYALTVKASDSAPP 596
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1810767034  597 aqRRSSITTVYIEVLPPN 614
Cdd:cd11304     81 --PLSSTATVTITVLDVN 96
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 653-720 4.14e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 4.14e-17
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1810767034   653 IRYLIENGDPQQVFNLSQSSGLLALGKPLDRESTDRYILIVTASD-GRPDGTSTATVNIVVTDVNDNGP 720
Cdd:smart00112   13 VTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDgGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 157-265 1.83e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.58  E-value: 1.83e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  157 YYVAVNELTPVGTTIFTgFSgnngATDIDDGPNGQIEYVIQYNPNDKTsnrtFDI-PLTlsGAVVLRERLNYEEKTRYFV 235
Cdd:cd11304      2 YEVSVPENAPPGTVVLT-VS----ATDPDSGENGEVTYSIVSGNEDGL----FSIdPST--GEITTAKPLDREEQSSYTL 70

                           90       100       110
                   ....*....|....*....|....*....|
gi 1810767034  236 IVQANDRAQNlheRRTSTTTLTVDVLDGDD 265
Cdd:cd11304     71 TVTATDGGGP---PLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
626-713 2.61e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.80  E-value: 2.61e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  626 YSLEVSEAMRTGAILLNLQAFDREGDP---IRYLIENGDPQQVFNLSQSSGLLALGKPLDRESTDRYILIVTASD-GRPD 701
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDsGGPP 80

                           90
                   ....*....|..
gi 1810767034  702 GTSTATVNIVVT 713
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
829-921 3.22e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.72  E-value: 3.22e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  829 YAVVVPENLPPGTVFLQIEAKDVDLGSN--VTYRIRTQEALEYFALNKYTGELSLRKSLDYESFSdtdaTFTFLVEAFDS 906
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNgrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIG----EYELTVEATDS 76

                           90
                   ....*....|....*
gi 1810767034  907 KGTMPPGLATVTVTV 921
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 936-1032 2.29e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 2.29e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  936 YRGMVAPDAVKGTVITTVSAEDQDPPgtPASRVRYKVDVVQfpySASIFDVEETSGRVVTRVNLNEEPSTVFKLVVIAYD 1015
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                           90
                   ....*....|....*..
gi 1810767034 1016 DGDPVKFNTTTVEITVL 1032
Cdd:cd11304     77 GGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 848-929 5.50e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 5.50e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034   848 AKDVDLGSN--VTYRIRTQEALEYFALNKYTGELSLRKSLDYESFSdtdaTFTFLVEAFDSKGTMPPGLATVTVTVKDMN 925
Cdd:smart00112    2 ATDADSGENgkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQP----EYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1810767034   926 DYSP 929
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 404-510 6.88e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.26  E-value: 6.88e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  404 TYEGFILESSPVGTTIsdsrnltspLQITVLDNDVEETKDPQLHLFLNDYNTFFTV-TQSGItryLTLLQPVDREAQQLY 482
Cdd:cd11304      1 SYEVSVPENAPPGTVV---------LTVSATDPDSGENGEVTYSIVSGNEDGLFSIdPSTGE---ITTAKPLDREEQSSY 68

                           90       100       110
                   ....*....|....*....|....*....|
gi 1810767034  483 TFSMIASDGVQE--STPVTVNIVVIDANDN 510
Cdd:cd11304     69 TLTVTATDGGGPplSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
533-611 4.27e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 4.27e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  533 VIKLTAVDADEGPNGQIVYEILAGDQGD-FIINDRTGLIAIApgVVLS--VGRSYALTVKASDSAPPAqrRSSITTVYIE 609
Cdd:pfam00028   15 VLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTT--KPLDreSIGEYELTVEATDSGGPP--LSSTATVTIT 90


                   ..
gi 1810767034  610 VL 611
Cdd:pfam00028   91 VL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1154-1248 3.62e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.26  E-value: 3.62e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034 1154 YIGGVSEDAKMFSSVLKVKADDKDTGNYSAMQYRLIIPpikDGKEGFVIEAYTGLIKTAMLFKNMRRSYFKFQVIATDDY 1233
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90
                   ....*....|....*
gi 1810767034 1234 GKGLSSKADVLVSVV 1248
Cdd:cd11304     79 GPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 181-268 4.02e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.52  E-value: 4.02e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034   181 ATDIDDGPNGQIEYVIQYNPNDktsnRTFDIpLTLSGAVVLRERLNYEEKTRYFVIVQANDRAQNlheRRTSTTTLTVDV 260
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDD----GLFSI-DPETGEITTTKPLDREEQPEYTLTVEATDGGGP---PLSSTATVTITV 73


                    ....*...
gi 1810767034   261 LDGDDLGP 268
Cdd:smart00112   74 LDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 537-618 8.94e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.75  E-value: 8.94e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034   537 TAVDADEGPNGQIVYEILAGDQGD-FIINDRTGLIAIAPGVVLSVGRSYALTVKASDSAPPaqRRSSITTVYIEVLPPNN 615
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVLDVND 78


                    ...
gi 1810767034   616 QSP 618
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 286-394 1.86e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.33  E-value: 1.86e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  286 TYQASLPELTDPAQVnpisVTPpIQAIDQDRNIQPPsdrpgILYSILvgtPEDYPQYFHMNLTTAELTLLKPINRDLHQK 365
Cdd:cd11304      1 SYEVSVPENAPPGTV----VLT-VSATDPDSGENGE-----VTYSIV---SGNEDGLFSIDPSTGEITTAKPLDREEQSS 67

                           90       100
                   ....*....|....*....|....*....
gi 1810767034  366 FDLVIKAEQDNGHPLPAFANLHIEVLDEN 394
Cdd:cd11304     68 YTLTVTATDGGGPPLSSTATVTITVLDVN 96
Cadherin pfam00028
Cadherin domain;
157-261 2.36e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.85  E-value: 2.36e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  157 YYVAVNELTPVGTTIftgfsGNNGATDIDDGPNGQIEYVIQYNPndktSNRTFDIPlTLSGAVVLRERLNYEEKTRYFVI 236
Cdd:pfam00028    1 YSASVPENAPVGTEV-----LTVTATDPDLGPNGRIFYSILGGG----PGGNFRID-PDTGDISTTKPLDRESIGEYELT 70

                           90       100
                   ....*....|....*....|....*
gi 1810767034  237 VQANDRAQnlhERRTSTTTLTVDVL 261
Cdd:pfam00028   71 VEATDSGG---PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
943-1032 2.23e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.15  E-value: 2.23e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  943 DAVKGTVITTVSAEDQDppGTPASRVRYKVdvvQFPYSASIFDVEETSGRVVTRVNLNEEPSTVFKLVVIAYDDGDPVKF 1022
Cdd:pfam00028    8 NAPVGTEVLTVTATDPD--LGPNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                           90
                   ....*....|
gi 1810767034 1023 NTTTVEITVL 1032
Cdd:pfam00028   83 STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 310-398 2.60e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.82  E-value: 2.60e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034   310 QAIDQDRNiqppsDRPGILYSILvgtPEDYPQYFHMNLTTAELTLLKPINRDLHQKFDLVIKAEQDNGHPLPAFANLHIE 389
Cdd:smart00112    1 SATDADSG-----ENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                    ....*....
gi 1810767034   390 VLDENNQKP 398
Cdd:smart00112   73 VLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 451-512 7.11e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.28  E-value: 7.11e-09
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1810767034   451 NDYNTFFTVTQSgiTRYLTLLQPVDREAQQLYTFSMIASDGVQE--STPVTVNIVVIDANDNSP 512
Cdd:smart00112   20 GNDDGLFSIDPE--TGEITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 954-1032 3.84e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.66  E-value: 3.84e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1810767034   954 SAEDQDPPgtPASRVRYKVDVvqfPYSASIFDVEETSGRVVTRVNLNEEPSTVFKLVVIAYDDGDPVKFNTTTVEITVL 1032
Cdd:smart00112    1 SATDADSG--ENGKVTYSILS---GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
405-505 3.46e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.30  E-value: 3.46e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  405 YEGFILESSPVGTTIsdsrnltspLQITVLDNDVEETKDPQLHLFLNDYNTFFTVTQsgITRYLTLLQPVDREAQQLYTF 484
Cdd:pfam00028    1 YSASVPENAPVGTEV---------LTVTATDPDLGPNGRIFYSILGGGPGGNFRIDP--DTGDISTTKPLDRESIGEYEL 69

                           90       100
                   ....*....|....*....|...
gi 1810767034  485 SMIASDGVQE--STPVTVNIVVI 505
Cdd:pfam00028   70 TVEATDSGGPplSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1158-1247 2.61e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 44.60  E-value: 2.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034 1158 VSEDAKMFSSVLKVKADDKDTGNYSAMQYRlIIPPIKDGKegFVIEAYTGLIKTAMLFKNMRRSYFKFQVIATDDYGKGL 1237
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYS-ILGGGPGGN--FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|
gi 1810767034 1238 SSKADVLVSV 1247
Cdd:pfam00028   82 SSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1172-1252 3.52e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 43.88  E-value: 3.52e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  1172 KADDKDTGNYSAMQYRLIIPpikDGKEGFVIEAYTGLIKTAMLFKNMRRSYFKFQVIATDDYGKGLSSKADVLVSVVNQL 1251
Cdd:smart00112    1 SATDADSGENGKVTYSILSG---NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    .
gi 1810767034  1252 D 1252
Cdd:smart00112   78 D 78
Cadherin pfam00028
Cadherin domain;
287-391 1.12e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.98  E-value: 1.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  287 YQASLPElTDPAQVNPISVTppiqAIDQDRNiqppsDRPGILYSILvgtPEDYPQYFHMNLTTAELTLLKPINRDLHQKF 366
Cdd:pfam00028    1 YSASVPE-NAPVGTEVLTVT----ATDPDLG-----PNGRIFYSIL---GGGPGGNFRIDPDTGDISTTKPLDRESIGEY 67

                           90       100
                   ....*....|....*....|....*
gi 1810767034  367 DLVIKAEQDNGHPLPAFANLHIEVL 391
Cdd:pfam00028   68 ELTVEATDSGGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
ECD pfam18432
Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be ...
 36-145 7.29e-69

Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be found at the N-terminal region of Protocadherin 15 (Pcdh15). Pcdh15 features exceptionally long extracellular domains containing 11 ECs. These repeats are structurally similar, but not identical in sequence, often featuring linkers with conserved calcium-binding sites that confer mechanical strength to them.


Pssm-ID: 408229  Cd Length: 110  Bit Score: 226.90  E-value: 7.29e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034   36 DCKLARTGPPATIVPIDEESRNGTILVDNMLIKGTAAGPDPTIELTLKDNVDYWVILDPISQRLYLNSTGRVLDRDPPMS 115
Cdd:pfam18432    1 DCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMN 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 1810767034  116 IQSIVVQVQCVNKKVGTIINHEVRIVVRDR 145
Cdd:pfam18432   81 IHSIVVQVQCVNKKVGTVIYHEVRIVVRDR 110
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1050-1145 1.89e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.09  E-value: 1.89e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034 1050 VSESAPKGTVVTVVMA----AALNQTIVYSIVSGNEEDMFAINNKTGVISVKKPLDYEKVTSYELRVQAdslqvvrSNLR 1125
Cdd:cd11304      6 VPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTA-------TDGG 78

                           90       100
                   ....*....|....*....|
gi 1810767034 1126 VPSKSNTAKVFIEVKDENDH 1145
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 828-926 1.27e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.78  E-value: 1.27e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  828 SYAVVVPENLPPGTVFLQIEAKDVDLGSN--VTYRIRTQEALEYFALNKYTGELSLRKSLDYEsfsdTDATFTFLVEAFD 905
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|.
gi 1810767034  906 SKGTMPPGLATVTVTVKDMND 926
Cdd:cd11304     77 GGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 729-820 1.40e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 1.40e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  729 NLSVQEEEA-NAFVGQVRATDPDAGVNGQVHYSLA--NFKNLFRI-TSNGSIYTAVKLNREVRDYYELIVEATDGAVDPR 804
Cdd:cd11304      3 EVSVPENAPpGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1810767034  805 RSTLTLAIKVLDIDDN 820
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 626-718 6.19e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.77  E-value: 6.19e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  626 YSLEVSEAMRTGAILLNLQAFDR---EGDPIRYLIENGDPQQVFNLSQSSGLLALGKPLDRESTDRYILIVTASD-GRPD 701
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDgGGPP 81

                           90
                   ....*....|....*..
gi 1810767034  702 GTSTATVNIVVTDVNDN 718
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 745-822 6.16e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.56  E-value: 6.16e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034   745 RATDPDAGVNGQVHYSLA--NFKNLFRITSN-GSIYTAVKLNREVRDYYELIVEATDGAVDPRRSTLTLAIKVLDIDDNS 821
Cdd:smart00112    1 SATDADSGENGKVTYSILsgNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1810767034   822 P 822
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1069-1147 2.73e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 2.73e-20
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1810767034  1069 NQTIVYSIVSGNEEDMFAINNKTGVISVKKPLDYEKVTSYELRVQAdslqvvrSNLRVPSKSNTAKVFIEVKDENDHAP 1147
Cdd:smart00112   10 NGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEA-------TDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
731-815 1.67e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.35  E-value: 1.67e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  731 SVQEEEA-NAFVGQVRATDPDAGVNGQVHYSLA--NFKNLFRI-TSNGSIYTAVKLNREVRDYYELIVEATDGAVDPRRS 806
Cdd:pfam00028    4 SVPENAPvGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIdPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                   ....*....
gi 1810767034  807 TLTLAIKVL 815
Cdd:pfam00028   84 TATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1050-1139 7.84e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.42  E-value: 7.84e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034 1050 VSESAPKGTVVTVVMA----AALNQTIVYSIVSGNEEDMFAINNKTGVISVKKPLDYEKVTSYELRVQAdslqvvrSNLR 1125
Cdd:pfam00028    5 VPENAPVGTEVLTVTAtdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA-------TDSG 77

                           90
                   ....*....|....
gi 1810767034 1126 VPSKSNTAKVFIEV 1139
Cdd:pfam00028   78 GPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 518-614 1.13e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.05  E-value: 1.13e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  518 SYSVKIYTDMGPGDGVIKLTAVDADEGPNGQIVYEILAGDQGD-FIINDRTGLIAIAPGVVLSVGRSYALTVKASDSAPP 596
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1810767034  597 aqRRSSITTVYIEVLPPN 614
Cdd:cd11304     81 --PLSSTATVTITVLDVN 96
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 653-720 4.14e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 4.14e-17
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1810767034   653 IRYLIENGDPQQVFNLSQSSGLLALGKPLDRESTDRYILIVTASD-GRPDGTSTATVNIVVTDVNDNGP 720
Cdd:smart00112   13 VTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDgGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 157-265 1.83e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.58  E-value: 1.83e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  157 YYVAVNELTPVGTTIFTgFSgnngATDIDDGPNGQIEYVIQYNPNDKTsnrtFDI-PLTlsGAVVLRERLNYEEKTRYFV 235
Cdd:cd11304      2 YEVSVPENAPPGTVVLT-VS----ATDPDSGENGEVTYSIVSGNEDGL----FSIdPST--GEITTAKPLDREEQSSYTL 70

                           90       100       110
                   ....*....|....*....|....*....|
gi 1810767034  236 IVQANDRAQNlheRRTSTTTLTVDVLDGDD 265
Cdd:cd11304     71 TVTATDGGGP---PLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
626-713 2.61e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.80  E-value: 2.61e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  626 YSLEVSEAMRTGAILLNLQAFDREGDP---IRYLIENGDPQQVFNLSQSSGLLALGKPLDRESTDRYILIVTASD-GRPD 701
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDsGGPP 80

                           90
                   ....*....|..
gi 1810767034  702 GTSTATVNIVVT 713
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
829-921 3.22e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.72  E-value: 3.22e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  829 YAVVVPENLPPGTVFLQIEAKDVDLGSN--VTYRIRTQEALEYFALNKYTGELSLRKSLDYESFSdtdaTFTFLVEAFDS 906
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNgrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIG----EYELTVEATDS 76

                           90
                   ....*....|....*
gi 1810767034  907 KGTMPPGLATVTVTV 921
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 936-1032 2.29e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 2.29e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  936 YRGMVAPDAVKGTVITTVSAEDQDPPgtPASRVRYKVDVVQfpySASIFDVEETSGRVVTRVNLNEEPSTVFKLVVIAYD 1015
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                           90
                   ....*....|....*..
gi 1810767034 1016 DGDPVKFNTTTVEITVL 1032
Cdd:cd11304     77 GGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 848-929 5.50e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 5.50e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034   848 AKDVDLGSN--VTYRIRTQEALEYFALNKYTGELSLRKSLDYESFSdtdaTFTFLVEAFDSKGTMPPGLATVTVTVKDMN 925
Cdd:smart00112    2 ATDADSGENgkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQP----EYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1810767034   926 DYSP 929
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 404-510 6.88e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.26  E-value: 6.88e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  404 TYEGFILESSPVGTTIsdsrnltspLQITVLDNDVEETKDPQLHLFLNDYNTFFTV-TQSGItryLTLLQPVDREAQQLY 482
Cdd:cd11304      1 SYEVSVPENAPPGTVV---------LTVSATDPDSGENGEVTYSIVSGNEDGLFSIdPSTGE---ITTAKPLDREEQSSY 68

                           90       100       110
                   ....*....|....*....|....*....|
gi 1810767034  483 TFSMIASDGVQE--STPVTVNIVVIDANDN 510
Cdd:cd11304     69 TLTVTATDGGGPplSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
533-611 4.27e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 4.27e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  533 VIKLTAVDADEGPNGQIVYEILAGDQGD-FIINDRTGLIAIApgVVLS--VGRSYALTVKASDSAPPAqrRSSITTVYIE 609
Cdd:pfam00028   15 VLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTT--KPLDreSIGEYELTVEATDSGGPP--LSSTATVTIT 90


                   ..
gi 1810767034  610 VL 611
Cdd:pfam00028   91 VL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1154-1248 3.62e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.26  E-value: 3.62e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034 1154 YIGGVSEDAKMFSSVLKVKADDKDTGNYSAMQYRLIIPpikDGKEGFVIEAYTGLIKTAMLFKNMRRSYFKFQVIATDDY 1233
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90
                   ....*....|....*
gi 1810767034 1234 GKGLSSKADVLVSVV 1248
Cdd:cd11304     79 GPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 181-268 4.02e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.52  E-value: 4.02e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034   181 ATDIDDGPNGQIEYVIQYNPNDktsnRTFDIpLTLSGAVVLRERLNYEEKTRYFVIVQANDRAQNlheRRTSTTTLTVDV 260
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDD----GLFSI-DPETGEITTTKPLDREEQPEYTLTVEATDGGGP---PLSSTATVTITV 73


                    ....*...
gi 1810767034   261 LDGDDLGP 268
Cdd:smart00112   74 LDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 537-618 8.94e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.75  E-value: 8.94e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034   537 TAVDADEGPNGQIVYEILAGDQGD-FIINDRTGLIAIAPGVVLSVGRSYALTVKASDSAPPaqRRSSITTVYIEVLPPNN 615
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVLDVND 78


                    ...
gi 1810767034   616 QSP 618
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 286-394 1.86e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.33  E-value: 1.86e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  286 TYQASLPELTDPAQVnpisVTPpIQAIDQDRNIQPPsdrpgILYSILvgtPEDYPQYFHMNLTTAELTLLKPINRDLHQK 365
Cdd:cd11304      1 SYEVSVPENAPPGTV----VLT-VSATDPDSGENGE-----VTYSIV---SGNEDGLFSIDPSTGEITTAKPLDREEQSS 67

                           90       100
                   ....*....|....*....|....*....
gi 1810767034  366 FDLVIKAEQDNGHPLPAFANLHIEVLDEN 394
Cdd:cd11304     68 YTLTVTATDGGGPPLSSTATVTITVLDVN 96
Cadherin pfam00028
Cadherin domain;
157-261 2.36e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.85  E-value: 2.36e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  157 YYVAVNELTPVGTTIftgfsGNNGATDIDDGPNGQIEYVIQYNPndktSNRTFDIPlTLSGAVVLRERLNYEEKTRYFVI 236
Cdd:pfam00028    1 YSASVPENAPVGTEV-----LTVTATDPDLGPNGRIFYSILGGG----PGGNFRID-PDTGDISTTKPLDRESIGEYELT 70

                           90       100
                   ....*....|....*....|....*
gi 1810767034  237 VQANDRAQnlhERRTSTTTLTVDVL 261
Cdd:pfam00028   71 VEATDSGG---PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
943-1032 2.23e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.15  E-value: 2.23e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  943 DAVKGTVITTVSAEDQDppGTPASRVRYKVdvvQFPYSASIFDVEETSGRVVTRVNLNEEPSTVFKLVVIAYDDGDPVKF 1022
Cdd:pfam00028    8 NAPVGTEVLTVTATDPD--LGPNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                           90
                   ....*....|
gi 1810767034 1023 NTTTVEITVL 1032
Cdd:pfam00028   83 STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 310-398 2.60e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.82  E-value: 2.60e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034   310 QAIDQDRNiqppsDRPGILYSILvgtPEDYPQYFHMNLTTAELTLLKPINRDLHQKFDLVIKAEQDNGHPLPAFANLHIE 389
Cdd:smart00112    1 SATDADSG-----ENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                    ....*....
gi 1810767034   390 VLDENNQKP 398
Cdd:smart00112   73 VLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 451-512 7.11e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.28  E-value: 7.11e-09
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1810767034   451 NDYNTFFTVTQSgiTRYLTLLQPVDREAQQLYTFSMIASDGVQE--STPVTVNIVVIDANDNSP 512
Cdd:smart00112   20 GNDDGLFSIDPE--TGEITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 954-1032 3.84e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.66  E-value: 3.84e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1810767034   954 SAEDQDPPgtPASRVRYKVDVvqfPYSASIFDVEETSGRVVTRVNLNEEPSTVFKLVVIAYDDGDPVKFNTTTVEITVL 1032
Cdd:smart00112    1 SATDADSG--ENGKVTYSILS---GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
405-505 3.46e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.30  E-value: 3.46e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  405 YEGFILESSPVGTTIsdsrnltspLQITVLDNDVEETKDPQLHLFLNDYNTFFTVTQsgITRYLTLLQPVDREAQQLYTF 484
Cdd:pfam00028    1 YSASVPENAPVGTEV---------LTVTATDPDLGPNGRIFYSILGGGPGGNFRIDP--DTGDISTTKPLDRESIGEYEL 69

                           90       100
                   ....*....|....*....|...
gi 1810767034  485 SMIASDGVQE--STPVTVNIVVI 505
Cdd:pfam00028   70 TVEATDSGGPplSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1158-1247 2.61e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 44.60  E-value: 2.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034 1158 VSEDAKMFSSVLKVKADDKDTGNYSAMQYRlIIPPIKDGKegFVIEAYTGLIKTAMLFKNMRRSYFKFQVIATDDYGKGL 1237
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYS-ILGGGPGGN--FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|
gi 1810767034 1238 SSKADVLVSV 1247
Cdd:pfam00028   82 SSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1172-1252 3.52e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 43.88  E-value: 3.52e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  1172 KADDKDTGNYSAMQYRLIIPpikDGKEGFVIEAYTGLIKTAMLFKNMRRSYFKFQVIATDDYGKGLSSKADVLVSVVNQL 1251
Cdd:smart00112    1 SATDADSGENGKVTYSILSG---NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    .
gi 1810767034  1252 D 1252
Cdd:smart00112   78 D 78
Cadherin pfam00028
Cadherin domain;
287-391 1.12e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.98  E-value: 1.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810767034  287 YQASLPElTDPAQVNPISVTppiqAIDQDRNiqppsDRPGILYSILvgtPEDYPQYFHMNLTTAELTLLKPINRDLHQKF 366
Cdd:pfam00028    1 YSASVPE-NAPVGTEVLTVT----ATDPDLG-----PNGRIFYSIL---GGGPGGNFRIDPDTGDISTTKPLDRESIGEY 67

                           90       100
                   ....*....|....*....|....*
gi 1810767034  367 DLVIKAEQDNGHPLPAFANLHIEVL 391
Cdd:pfam00028   68 ELTVEATDSGGPPLSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 659-718 6.40e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 38.09  E-value: 6.40e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1810767034  659 NGDPQQVFNLSQSSGLLALGKPLDRESTDRYILIVTASdgRPDGTSTAT---VNIVVTDVNDN 718
Cdd:cd00031     38 KEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAA--SLGANVPQTssvFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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