|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
4-1039 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 1463.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 4 DFPAEEEITLKRWREINAFGRQVELSRGRKPYTFYDGPPFATGLPHYGHLLASTIKDIIPRYWSMKGHYVERRFGWDTHG 83
Cdd:PLN02882 9 SFPKQEEKILSLWSEIDAFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 84 VPIEYEIDKKLGMSGLEAVEKLGIEKYNEECRAIVMRFASEWRETIERLGRWIDFDNDYKTMNSSFMESVWWVFKQLFDK 163
Cdd:PLN02882 89 LPVEYEIDKKLGIKRRDDVLKMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEK 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 164 GLVYRGYRVMPYSTALNTPLSNFEAQQNYKDVQDPAVVVSFPLVDDPE-TCLLAWTTTPWTLPSNVALAVNPGFEYIKIF 242
Cdd:PLN02882 169 GLVYKGFKVMPYSTACKTPLSNFEAGLNYKDVSDPAVMVSFPIVGDPDnASFVAWTTTPWTLPSNLALCVNPNFTYVKVR 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 243 DEASKKHYILLESLLRTLYKDPKKAK-----------FKIVDRFKGVDMKDWKYQPLFDYFyEEFKDYGFRVINGDYVSA 311
Cdd:PLN02882 249 NKYTGKVYIVAESRLSALPTAKPKSKkgskpenaaegYEVLAKVPGSSLVGKKYEPLFDYF-SEFSDTAFRVVADDYVTD 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 312 EDGTGIVHQSPAFGEEDYNVAMASGVISETRLPPNPVDEKGCFTAEVRDFVGQHVKAADKAIIKHLKGIGRLIVDSQITH 391
Cdd:PLN02882 328 DSGTGVVHCAPAFGEDDYRVCLANGIIEKGGNLPVPVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGRLVKSGSITH 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 392 SYPFCWRSDTPLIYRAVPSWFVKIGPIIPQMLQGIEESHWVPSFVKERRFASWIQNARDWNISRNRFWGTPLPLWVSDDF 471
Cdd:PLN02882 408 SYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYVKEKRFHNWLENARDWAVSRSRFWGTPLPIWISDDG 487
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 472 KEVVAVGSVEELKQLSGYegEITDLHRDKVDKITIPSKQGK--GVLRRVSEVFDCWFESGSMPYASQHYPFENKEQFEKS 549
Cdd:PLN02882 488 EEVVVIGSIAELEKLSGV--KVTDLHRHFIDHITIPSSRGPefGVLRRVDDVFDCWFESGSMPYAYIHYPFENKELFEKN 565
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 550 FPGDFIAEGLDQTRGWFYTLTVLGTHLFGTLPFKNCVVNGIVLAEDGKKMSKRLKNYPDPTLIMQRYGSDALRLYLINSP 629
Cdd:PLN02882 566 FPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALRLYLINSP 645
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 630 VVRAEPLRFKESGVKEIVAKVLLPLWNSYKFFEGQAALFKKNNSIDFV-FDPKAEATNTNVMDRWILASCQSLLKFVNEE 708
Cdd:PLN02882 646 VVRAEPLRFKEEGVFGVVKDVFLPWYNAYRFLVQNAKRLEVEGGAPFVpLDLAKLQNSANVLDRWINSATQSLVKFVREE 725
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 709 MAGYRLYTVVPRLLELIDNTTNWYIRFNRKRLKGENGIDDTLHALNTLFEVLYTLVRGLAPFTPFITDTIYQKLLAHIPq 788
Cdd:PLN02882 726 MGAYRLYTVVPYLVKFIDNLTNIYVRFNRKRLKGRTGEEDCRTALSTLYNVLLTSCKVMAPFTPFFTEVLYQNLRKVLP- 804
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 789 alrgEDSRSVHFLPFPEVREELFDEVVERRVARMQKVIEMARVSRERRSIGLKSPLKTLVVIHQDQQYLDDVK-SLEGYI 867
Cdd:PLN02882 805 ----GSEESIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRERHNKPLKTPLKEMVVVHPDAEFLDDITgKLKEYV 880
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 868 LEELNVLELVLSSDEAKYnVQYSVSADWPTLGKKLKKDAQKVKKALPSLTSDDVKKFVAEKKMLVDGIELVEGDLVVKRG 947
Cdd:PLN02882 881 LEELNVRSLVPCNDPLKY-ASLRAEPNFSVLGKRLGKSMGLVAKEVKAMSQDDILEFEKAGEVTIAGHTLKAGDIKVVRD 959
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 948 LK--EDVASEGMEPNADADVLTILDANLYPELAQQGLGREIINRLQRLRKKAGLVPTDDVRMEYAVLSDPDSVGINEAFE 1025
Cdd:PLN02882 960 FKrpEGVSKEDIDAAGDGDVLVILDLRVDESLLEAGVAREVVNRIQKLRKKAGLEPTDKVEVFFESLDEVDESALSQVLK 1039
|
1050
....*....|....
gi 1832834855 1026 TQAKAIEKAVRRPL 1039
Cdd:PLN02882 1040 SQAQYIRESLGSPL 1053
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
8-1063 |
0e+00 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 1066.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 8 EEEITLKRWREINAFGRQVELSRGRKPYTFYDGPPFATGLPHYGHLLASTIKDIIPRYWSMKGHYVERRFGWDTHGVPIE 87
Cdd:PTZ00427 77 EEEKVLKYWKSIDAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIE 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 88 YEIDKKLGMSGLEAVEKLGIEKYNEECRAIVMRFASEWRETIERLGRWIDFDNDYKTMNSSFMESVWWVFKQLFDKGLVY 167
Cdd:PTZ00427 157 YEIEKENNINKKEDILKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVY 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 168 RGYRVMPYSTALNTPLSNFEAQQNYKDVQDPAVVVSFPLVDD----PETC------------------------------ 213
Cdd:PTZ00427 237 KSFKVMPYSCKCNTPISNFELNLNYKDTPDPSIIISFVLCSDfpkvEEECnieedkqllgekysvlynnkrensnngnnn 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 214 ------------LLAWTTTPWTLPSNVALAVNPGFEYIKIFDEASKKHYILLESLLRTLYKDPK--KAKFKIVDRFKGVD 279
Cdd:PTZ00427 317 stnnvcyaqhseILAWTTTPWTLPSNLALCVNEHFTYLRIHHVKSNRVVIVGECRLEWIMKELKwnVEDLKIVNRFKGKE 396
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 280 MKDWKYQPLFDYFYEE--FKDYGFRVINGDYVSAEDGTGIVHQSPAFGEEDYNVAMASGVIS-ETRLPPNPVDEKGCFTA 356
Cdd:PTZ00427 397 LKGLRYKPLFTNFYEKynFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVIDpEKNIFIDPLDANGYFTN 476
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 357 EVRDFVGQHVKAADKAIIKHLKGIGRLIVDSQITHSYPFCWRSDTPLIYRAVPSWFVKIGPIIPQMLQGIEESHWVPSFV 436
Cdd:PTZ00427 477 EVEEVQNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELVKNNETTYWIPAHI 556
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 437 KERRFASWIQNARDWNISRNRFWGTPLPLWVSDDFKEVVAVGSVEELKQLSGYEgEITDLHRDKVDKITIPSKQGKGV-- 514
Cdd:PTZ00427 557 KEKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMETVICVESIKHLEELSGVK-NINDLHRHFIDHIEIKNPKGKTYpk 635
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 515 LRRVSEVFDCWFESGSMPYASQHYPFEN-KEQFEKSFPGDFIAEGLDQTRGWFYTLTVLGTHLFGTLPFKNCVVNGIVLA 593
Cdd:PTZ00427 636 LKRIPEVFDCWFESGSMPYAKVHYPFSTeKEDFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKNLICNGLVLA 715
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 594 EDGKKMSKRLKNYPDPTLIMQRYGSDALRLYLINSPVVRAEPLRFKESGVKEIVAKVLLPLWNSYKFFEGQAALFKKNNS 673
Cdd:PTZ00427 716 SDGKKMSKRLKNYPDPLYILDKYGADSLRLYLINSVAVRAENLKFQEKGVNEVVKSFILPFYHSFRFFSQEVTRYECLNK 795
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 674 IDFVFDPKAEATNTNVMDRWILASCQSLLKFVNEEMAGYRLYTVVPRLLELIDNTTNWYIRFNRKRLKGENGIDDTLHAL 753
Cdd:PTZ00427 796 KQFLFNTDYIYKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFIENLTNWYIRLNRDRMRGSLGEENCLQSL 875
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 754 NTLFEVLYTLVRGLAPFTPFITDTIYQKL--LAHIPQALRGEDS--------------RSVHFLPFPEVREE--LFDEVV 815
Cdd:PTZ00427 876 CTTYRTLHLFTVLMAPFTPFITEYIYQQLrrVKSTNEHNENNETgntkegdlnrgvihKSVHFIMLPQVDEKyiIDYEII 955
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 816 ErRVARMQKVIEMARVSRERRSIGLKSPLKTLVVIHQDQQYLDDVKSLEGYILEELNVLELVLSSDEAkyNVQYSVSADW 895
Cdd:PTZ00427 956 E-LIEKMKDVILLGRVLRERRKVASKKPLKSITILHPNESYFKNFDQISNYIKEELNVLNVECSNDTS--CLDFSAIPNY 1032
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 896 PTLGKKLKKDAQKVKKALPSLTSDDVKKFVAEKKMLVDGIELVEGDLVVKrgLKEDVASEGMEPNADADVLTILDANLYP 975
Cdd:PTZ00427 1033 KTLGVKLGYNLKKVQNKIKNMDSESIKLYQQEGKITLDNVTLEGDDIIIQ--MKPNFQNDNTDIISNNYVTILMDFTTDQ 1110
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 976 ELAQQGLGREIINRLQRLRKKAGLVPTDDVRMEYAVLSDpdsvGINEAFETQAKAIEKAVRRPLEqvaVVDgkvSSGDKE 1055
Cdd:PTZ00427 1111 QLENMASARELCNHIQKMRKNLSLNQNSPVKMHVYIADD----TLRNNMVSEMEYIKKCLRRELN---VIP---SQEDYQ 1180
|
1130
....*....|
gi 1832834855 1056 GLI--MEEEQ 1063
Cdd:PTZ00427 1181 NLAdkMHDEE 1190
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
1-898 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1031.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 1 MSIDFPAEEEITLKRWREINAFGRQVELSRGRKPYTFYDGPPFATGLPHYGHLLASTIKDIIPRYWSMKGHYVERRFGWD 80
Cdd:COG0060 14 MRANLPKREPEILKFWEENDIYEKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWD 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 81 THGVPIEYEIDKKLGMSGLEaVEKLGIEKYNEECRAIVMRFASEWRETIERLGRWIDFDNDYKTMNSSFMESVWWVFKQL 160
Cdd:COG0060 94 CHGLPIELKVEKELGIKKKD-IEKVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPEYEESIWWALKKL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 161 FDKGLVYRGYRVMPYSTALNTPLSNFEAqqNYKDVQDPAVVVSFPLVDDPE------TCLLAWTTTPWTLPSNVALAVNP 234
Cdd:COG0060 173 YEKGLLYKGLKPVPWCPRCGTALAEAEV--EYKDVTSPSIYVKFPVKDEKAlllledAYLVIWTTTPWTLPANLAVAVHP 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 235 GFEYIKIFDEASKKhYILLESLLRTLYKDPKKAKFKIVDRFKGVDMKDWKYQPLFDYFyeEFKDYGFRVINGDYVSAEDG 314
Cdd:COG0060 251 DIDYVLVEVTGGER-LILAEALVEAVLKELGIEDYEVLATFKGAELEGLRYEHPFYYV--VGYDRAHPVILGDYVTTEDG 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 315 TGIVHQSPAFGEEDYNVAMASGvisetrLPP-NPVDEKGCFTAEVRDFVGQHVKAADKAIIKHLKGIGRLIVDSQITHSY 393
Cdd:COG0060 328 TGIVHTAPGHGEDDFEVGKKYG------LPVlNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKITHSY 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 394 PFCWRSDTPLIYRAVPSWFVKIGPIIPQMLQGIEESHWVPSFvKERRFASWIQNARDWNISRNRFWGTPLPLWVSDDFKE 473
Cdd:COG0060 402 PHCWRCKTPLIYRATPQWFISMDKLRDRALEAIEKVNWIPEW-GEGRFGNMLENRPDWCISRQRYWGVPIPIWVCEDCGE 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 474 VVA----VGSVEE-LKQlsgyEGE----ITDLHRDKVDKiTIPSKQGKGVLRRVSEVFDCWFESGSMPYASqhypFENKE 544
Cdd:COG0060 481 LHRteevIGSVAElLEE----EGAdawfELDLHRPFLDE-TLKCPKCGGTMRRVPDVLDVWFDSGSMHFAV----LENRE 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 545 qfEKSFPGDFIAEGLDQTRGWFYTLTVLGTHLFGTLPFKNCVVNGIVLAEDGKKMSKRLKNYPDPTLIMQRYGSDALRLY 624
Cdd:COG0060 552 --ELHFPADFYLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGADILRLW 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 625 LINSPvvRAEPLRFKESGVKEiVAKVLLPLWNSYKFFegQAALFKknnsidfvFDPKAEA---TNTNVMDRWILASCQSL 701
Cdd:COG0060 630 VASSD--YWGDLRFSDEILKE-VRDVYRRLRNTYRFL--LANLDD--------FDPAEDAvpyEDLPELDRWILSRLNEL 696
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 702 LKFVNEEMAGYRLYTVVPRLLELIDNT-TNWYIRFNRKRL-KGENGIDDTLHALNTLFEVLYTLVRGLAPFTPFITDTIY 779
Cdd:COG0060 697 IKEVTEAYDNYDFHRAYRALHNFCVEDlSNWYLDISKDRLyTEAADSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEIW 776
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 780 qkllahipQALRGEDSRSVHFLPFPEVREELFDEVVERRVARMQKVIEMARVSRE--RRSIGLKSPLKTLVVIHQDQQYL 857
Cdd:COG0060 777 --------QNLPGEAEESVHLADWPEVDEELIDEELEAKWDLVREVRSAVLKALEaaRKEKLIRQPLEAAVVLYADEELA 848
|
890 900 910 920
....*....|....*....|....*....|....*....|.
gi 1832834855 858 DDVKSLEGYILEELNVLELVLSSDEAKYNVQYSVSADWPTL 898
Cdd:COG0060 849 AALESLGDLLAEELNVSEVELVDDAEDLGKDALKALDVEGI 889
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
1-861 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 986.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 1 MSIDFPAEEEITLKRWREINAFGRQVELSRGRKPYTFYDGPPFATGLPHYGHLLASTIKDIIPRYWSMKGHYVERRFGWD 80
Cdd:TIGR00392 4 MRGNLSKREEKILAFWQENDIFEKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPGWD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 81 THGVPIEYEIDKKLGMSGLEAVEKLGIEKYNEECRAIVMRFASEWRETIERLGRWIDFDNDYKTMNSSFMESVWWVFKQL 160
Cdd:TIGR00392 84 THGLPIEHKVEKKLGISGKKEISSLEIEEFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFKEA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 161 FDKGLVYRGYRVMPYSTALNTPLSNFEAQQ--NYKDVQDPAVVVSFPLVDDPET-------CLLAWTTTPWTLPSNVALA 231
Cdd:TIGR00392 164 HEKGLLYRGLKPVYWSPRCRTALAEAEVEYkeNYKDVKDPSIYVKFPVKKDKKTylkvklsSLLIWTTTPWTLPSNLAIA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 232 VNPGFEYIKIFDEASKKHYILLESLLRTLYKDPKKaKFKIVDRFKGVDMKDWKYQPLFDYFYEEFKDYGFRVINGDYVSA 311
Cdd:TIGR00392 244 VHPDFEYALVQDNTKVEYFILAKKLVEKLYNKAGS-DYEIIKTFKGSDLEGLEYEHPLYDFVSQLKEGAPVVIGGDHVTT 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 312 EDGTGIVHQSPAFGEEDYNVAMASGVISetrlpPNPVDEKGCFTAEVRDFVGQHVK-------AADKAIIKHLKGIGRLI 384
Cdd:TIGR00392 323 EDGTGIVHTAPGHGEEDYEIGKKYGLEV-----LSPVDEKGVYTEGVNDFQGRFVKdadkdiiKANKIIIEQLKDKGLLL 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 385 VDSQITHSYPFCWRSDTPLIYRAVPSWFVKIGPIIPQMLQGIEESHWVPSFVKErRFASWIQNARDWNISRNRFWGTPLP 464
Cdd:TIGR00392 398 KAEKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWGEG-RFGNWLENRPDWCISRQRYWGIPIP 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 465 LWVSDDFKEVVAVGSVEELKQ---LSGYEGEITDLHRDKVDKITIPSKQGkGVLRRVSEVFDCWFESGSMPYASQHYPFE 541
Cdd:TIGR00392 477 IWYCEDTGEPIVVGSIEELIElieLKGIDAWFEDLHRDFLDKITLKSGDG-GEYRRVPDVLDVWFDSGSMPYASIHYPFE 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 542 NkEQFEKSFPGDFIAEGLDQTRGWFYTLTVLGTHLFGTLPFKNCVVNGIVLAEDGKKMSKRLKNYPDPTLIMQRYGSDAL 621
Cdd:TIGR00392 556 N-EKFKEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVINKYGADIL 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 622 RLYLINSpvVRAEPLRFKESGVKEIVAKVLLPLWNSYKFFEGQAALFkknnsiDFVFDPKAEA-TNTNVMDRWILASCQS 700
Cdd:TIGR00392 635 RLYVASS--DPWEDLRFSDEILKQVVEKYRKIRWNTYRFLLTYANLD------KFDPLFNSVAvEKFPEEDRWILSRLNS 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 701 LLKFVNEEMAGYRLYTVVPRLLELIDNT-TNWYIRFNRKRLKGENGIDDTLHALNTLFEVLYTLVRGLAPFTPFITDTIY 779
Cdd:TIGR00392 707 LVEEVNEALEKYNFHKVLRALQDFIVEElSNWYIRIIRDRLYCEAKDNDKRAAQTTLYYALLTLVRLLAPFLPHTAEEIY 786
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 780 QKLlahipqaLRGEDSRSVHFLPFPEVREELFDEVVERRVARMQKVIEMARVSRERRSIGLKSPLKTLVVIHQDQQYLDD 859
Cdd:TIGR00392 787 QNL-------PGGEEEESVHLNLWPEVDEEFIDEALEANMAIVREIVEAFLALRDAANKKLRQPLKELVIGKSLEAVLKA 859
|
..
gi 1832834855 860 VK 861
Cdd:TIGR00392 860 VE 861
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
13-637 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 817.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 13 LKRWREINAFGRQVELSRGRKPYTFYDGPPFATGLPHYGHLLASTIKDIIPRYWSMKGHYVERRFGWDTHGVPIEYEIDK 92
Cdd:pfam00133 3 YEFWDEQGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVVEK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 93 KLGMSGLEAVEKLGIEKYNEECRAIVMRFASEWRETIERLGRWIDFDNDYKTMNSSFMESVWWVFKQLFDKGLVYRGYRV 172
Cdd:pfam00133 83 KLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGKKL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 173 MPYSTALNTPLSNFEAqqNYKDVQDPAVVVSFPLVDDPETCLLAWTTTPWTLPSNVALAVNPGFEYIKifdeaSKKHYIL 252
Cdd:pfam00133 163 VNWSPALNTALSNLEV--EYKDVKGPSIHVAFPLADDEGASLVIWTTTPWTLPGNTAVAVNPEFDYVI-----TGEGYIL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 253 LESLLRTLYKdpKKAKFKIVDRFKGVDMKDWKYQPLfdyfyeeFKDYGFRVINGDYVSAEDGTGIVHQSPAFGEEDYNVA 332
Cdd:pfam00133 236 AEALLKSLYK--KGTDKKILEDFRGKELEGKEAIHP-------FVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVG 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 333 MASGVisetrLPPNPVDEKGCFTAEVRDFVGQHVKAADKAIIKHLKGIGRLIVDSQITHSYPFCWRSDTPLIYRAVPSWF 412
Cdd:pfam00133 307 QRHNL-----EVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWF 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 413 VKIGPIIPQMLQGIEESHWVPSFvKERRFASWIQNARDWNISRNRFWGTPLPLWVSDDFKEVVAVGSVEEL-KQLSGYEG 491
Cdd:pfam00133 382 VRMDELADQALEAVEKVQFVPKS-GEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELvAGRFEEEG 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 492 EITDLHRDKVDKItipsKQGKGVLRRVSEVFDCWFESGSMPYASQHYPFENKEQFEKSFPGDFIAEGLDQTRGWFYTLTV 571
Cdd:pfam00133 461 SIKWLHREAKDKL----GYGKGTLEQDEDVLDTWFSSGSWPFSTLGWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIM 536
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1832834855 572 LGTHLFGTLPFKNCVVNGIVLAEDGKKMSKRLKNYPDPTLIMQRYGSDALRLYLINSPVVRAEPLR 637
Cdd:pfam00133 537 LSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANSDYGRDINLS 602
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
4-955 |
6.25e-122 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 394.81 E-value: 6.25e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 4 DFPAEEEITLKRWREINAFgrQVELSRGRKPYTFYDGPPFATGLPHYGHLLASTIKDIIPRYWSMKGHYVERRFGWDTHG 83
Cdd:TIGR00422 6 DPHEVEKKWYKKWEKSGFF--KPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 84 VPIEYEIDKKLGMSGLEAvEKLGIEKYNEECRAIVMRFASEWRETIERLGRWIDFDNDYKTMNSSFMESVWWVFKQLFDK 163
Cdd:TIGR00422 84 IATQVKVEKKLGAEGKTK-HDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLYEK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 164 GLVYRGYRVMPYSTALNTPLSNFEAQqnYKDVQDPAVVVSFPLVDDPETCLLAWTTTPWTLPSNVALAVNPgfeyikifD 243
Cdd:TIGR00422 163 GLIYRGEYLVNWDPKLNTAISDIEVE--YKEVKGKLYYIRYPLANGSKDYLVVATTRPETMFGDTAVAVHP--------E 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 244 EASKKHYIllesllrtlykdpkkAKFKIVdrfkgvdmkdwkyqPLFDYFYEEFKDygfrvingDYVSAEDGTGIVHQSPA 323
Cdd:TIGR00422 233 DERYKHLI---------------GKKVIL--------------PLTGRKIPIIAD--------EYVDMEFGTGAVKVTPA 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 324 FGEEDYNVAmasgviSETRLP-PNPVDEKGCFTAEVRDFVGQHVKAADKAIIKHLKGIGRLIVDSQITHSYPFCWRSDTP 402
Cdd:TIGR00422 276 HDFNDYEWG------KRHNLEfINILDEDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTV 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 403 LIYRAVPSWFVKIGPIIPQMLQGIEESH--WVPSFVKERRFaSWIQNARDWNISRNRFWGTPLPLWVSDDFKEVVaVGSV 480
Cdd:TIGR00422 350 VEPLLSKQWFVKVEKLADKALEAAEEGEikFVPKRMEKRYL-NWLRNIKDWCISRQLIWGHRIPVWYCKECGEVY-VAKE 427
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 481 EELKQLSGYEGEITDLHRDKvdkitipskqgkgvlrrvsEVFDCWFESGSMPYASQHYPfENKEQFEKSFPGDFIAEGLD 560
Cdd:TIGR00422 428 EPLPDDKTNTGPSVELEQDT-------------------DVLDTWFSSSLWPFSTLGWP-DETKDLKKFYPTDLLVTGYD 487
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 561 QTRGWFYTLTVLGTHLFGTLPFKNCVVNGIVLAEDGKKMSKRLKNYPDPTLIMQRYGSDALRLYLINSpVVRAEPLRFKE 640
Cdd:TIGR00422 488 IIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASL-VTPGDDINFDW 566
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 641 SGVkEIVAKVLLPLWNSYKFfegqaALFKKNNSIDFVFDPKaeatNTNVMDRWILASCQSLLKFVNEEMAGYRLYTVVPR 720
Cdd:TIGR00422 567 KRV-ESARNFLNKLWNASRF-----VLMNLSDDLELSGGEE----KLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKA 636
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 721 LLELI-DNTTNWYIRFNRKRLKGENgIDDTLHALNTLFEVLYTLVRGLAPFTPFITDTIYQKLlahipqalrGEDSRSVH 799
Cdd:TIGR00422 637 LYEFIwNDFCDWYIELVKYRLYNGN-EAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHF---------KEGADSIM 706
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 800 FLPFPEVREELFDEVVERRVARMQKVIEMARVSRERRSIGLKSPLKtLVVIHQDQQYLDDVKSLEGYI--LEELNVLELV 877
Cdd:TIGR00422 707 LQSYPVVDAEFVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPLK-VLLIYTEAETAERLKLNAVDIkgAINFSEVEVV 785
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1832834855 878 LSSDEAKYNVQYSVSadwptlGKKLKKDAQKVKKALPSLTSddVKKFVAEKKMLVDGIEL-VEGDLVVKRGLKEDVASE 955
Cdd:TIGR00422 786 IEKPEVTEAVVELVP------GFEIIIPVKGLINKAKELAR--LQKQLDKEKKEVIRIEGkLENEGFVKKAPKEVIEKE 856
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
8-851 |
1.66e-110 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 367.17 E-value: 1.66e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 8 EEEITlKRWREINAFGRQVELSRGrKPYTFYDGPPFATGLPHYGHLLASTIKDIIPRYWSMKGHYVERRFGWDTHGVPIE 87
Cdd:PLN02843 9 EPEIQ-KLWEENQVYKRVSDRNNG-ESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 88 YEIDKKLGMsglEAVEKLGIEKYNEECRAIVMRFASEWRETIERLGRWIDFDNDYKTMNSSFMESVWWVFKQLFDKGLVY 167
Cdd:PLN02843 87 LKVLQSLDQ---EARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIY 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 168 RGYRVMPYSTALNTPLSnfEAQQNYKDVQ-DPAVVVSFPLVDDPET------------CLLAWTTTPWTLPSNVALAVNP 234
Cdd:PLN02843 164 RGRKPVHWSPSSRTALA--EAELEYPEGHvSKSIYVAFPVVSPSETspeeleeflpglSLAIWTTTPWTMPANAAVAVND 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 235 GFEY----IKIFDEASKKHYILLESLLRTLYKDPKK------------------AKFKIVDRFKGVDMKDWKYQ-PLFDy 291
Cdd:PLN02843 242 KLQYsvveVQSFSEDESTSGGNKKKRPGNVLKEQQKlflivatdlvpaleakwgVKLVVLKTFPGSDLEGCRYIhPLYN- 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 292 fyeefkdygfR----VINGDYVSAEDGTGIVHQSPAFGEEDYNVAMASGvisetrLP-PNPVDEKGCFTAEVRDFVGQHV 366
Cdd:PLN02843 321 ----------RespvVIGGDYITTESGTGLVHTAPGHGQEDYITGLKYG------LPlLSPVDDAGKFTEEAGQFSGLSV 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 367 -KAADKAIIKHLKGIGRLIVDSQITHSYPFCWRSDTPLIYRAVPSWFVKIGPIIPQMLQGIEESHWVPSfVKERRFASWI 445
Cdd:PLN02843 385 lGEGNAAVVEALDEAGSLLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIPA-QGENRIRAMV 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 446 QNARDWNISRNRFWGTPLPLWVSDDFKEVV----AVGSVEELKQLSG----YEGEITDL----HRDKVDKitipskqgkg 513
Cdd:PLN02843 464 SGRSDWCISRQRTWGVPIPVFYHVETKEPLmneeTIAHVKSIVAQKGsdawWYMDVEDLlpekYRDKASD---------- 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 514 vLRRVSEVFDCWFESGSmpyaSQHYPFENKEqfEKSFPGDFIAEGLDQTRGWFYT--LTVLGTHlfGTLPFKNCVVNGIV 591
Cdd:PLN02843 534 -YEKGTDTMDVWFDSGS----SWAGVLGSRE--GLSYPADLYLEGSDQHRGWFQSslLTSVATK--GKAPYKSVLTHGFV 604
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 592 LAEDGKKMSKRLKNYPDPTLIMQ---------RYGSDALRLY----------LINSPVVRAeplrfkesgVKEIVAKvll 652
Cdd:PLN02843 605 LDEKGFKMSKSLGNVVDPRLVIEggknqkqepAYGADVLRLWvasvdytgdvLIGPQILKQ---------MSDIYRK--- 672
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 653 pLWNSYKFFEGQAALFKKNNSIDFVFDPKaeatntnvMDRWILASCQSLLKFVNEEMAGYRLYTVVPRLLEL-IDNTTNW 731
Cdd:PLN02843 673 -LRGTLRYLLGNLHDWKPDNAVPYEDLPS--------IDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFtIVDLSNF 743
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 732 YIRFNRKRLKGENGIDDTLHALNT-LFEVLYTLVRGLAPFTPFITDTIYQkllaHIPQALRGEDSRSVHFLPFPEVREE- 809
Cdd:PLN02843 744 YLDVAKDRLYVGGTTSFTRRSCQTvLAAHLLSLLRAIAPILPHLAEDAWQ----NLPFQEDGSAAESVFEAGWPTPNEEw 819
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|.
gi 1832834855 810 ---------LFDEVVERRVArMQKVIEMARVSrerRSIGlkSPLKTLVVIH 851
Cdd:PLN02843 820 lsfpaedvdFWSLLLEVRDE-VNKVLESARNG---KLIG--ASLEAKVYLH 864
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
402-638 |
8.86e-102 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 323.80 E-value: 8.86e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 402 PLIYRAVPSWFVKIGPIIPQMLQGIEESHWVPSFVKERrFASWIQNARDWNISRNRFWGTPLPLWVSDDFKEVVavgsve 481
Cdd:cd00818 144 PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPEWVKNR-FGNWLENRRDWCISRQRYWGTPIPVWYCEDCGEVL------ 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 482 elkqlsgyegeitdlhrdkvdkitipskqgkgvLRRVSEVFDCWFESGSMPYASQHYPFENKEqFEKSFPGDFIAEGLDQ 561
Cdd:cd00818 217 ---------------------------------VRRVPDVLDVWFDSGSMPYAQLHYPFENED-FEELFPADFILEGSDQ 262
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1832834855 562 TRGWFYTLTVLGTHLFGTLPFKNCVVNGIVLAEDGKKMSKRLKNYPDPTLIMQRYGSDALRLYLINSPvVRAEPLRF 638
Cdd:cd00818 263 TRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVVDKYGADALRLWVASSD-VYAEDLRF 338
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
4-888 |
2.14e-100 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 335.24 E-value: 2.14e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 4 DFPAEEEITLKRWRE--INAFgrqvELSRGRKPYTFYDGPPFATGLPHYGHLLASTIKDIIPRYWSMKGHYVERRFGWDT 81
Cdd:PRK13208 11 DPEELEEKWQKIWEEegTYKF----DPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWDD 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 82 HGVPIEYEIDKKLGMSgleaVEKLGIEKYNEECRAIVMRFASEWRETIERLGRWIDFDNDYKTMNSSFMESVWWVFKQLF 161
Cdd:PRK13208 87 NGLPTERKVEKYYGIR----KDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 162 DKGLVYRGYRVMPYSTALNTPLSnfEAQQNYKDVQDPAVVVSFPLVDDpETCLLAwTTTPWTLPSNVALAVNPgfeyiki 241
Cdd:PRK13208 163 KKGLIYRAEAPVLWCPRCETAIA--QAEVEYREREGKLNYIKFPVEDG-EEIEIA-TTRPELLPACVAVVVHP------- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 242 fDEASKKHYIllesllrtlykdpkkAKFKIVdrfkgvdmkdwkyqPLFDYfyeEFKdygfrVINGDYVSAEDGTGIVHQS 321
Cdd:PRK13208 232 -DDERYKHLV---------------GKTAIV--------------PLFGV---EVP-----ILADPLVDPDFGTGAVMIC 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 322 pAFGEE-------DYNvamasgvisetrLPPNPV-DEKGCFTAEVRDFVGQHVKAADKAIIKHLKGIGRLIVDSQITHSY 393
Cdd:PRK13208 274 -TFGDKtdvtwwrELN------------LPTRIIiDEDGRMTEAAGKLAGLTIEEARKKIVEDLKSGGLLGKQEPIKHNV 340
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 394 PFCWRSDTPLIYRAVPSWFVKIGPIIPQMLQGIEESHWVPSFVKeRRFASWIQN-ARDWNISRNRFWGTPLPLWVSDDFK 472
Cdd:PRK13208 341 KFCERCDTPLEILVTRQWFIKVLDLKEELLERGKEINWYPEHMR-VRLENWIEGlNWDWCISRQRYFGTPIPVWYCKDCG 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 473 EVVaVGSVEELkqlsgyegeitdlhrdKVDkitiPSKQ----------GKGVLRRVSEVFDCWFESGSMPYASQHYPfEN 542
Cdd:PRK13208 420 HPI-LPDEEDL----------------PVD----PTKDeppgykcpqcGSPGFEGETDVMDTWATSSITPLIVTGWE-RD 477
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 543 KEQFEKSFPGDFIAEGLDQTRGW-FYtlTVLGTH-LFGTLPFKNCVVNGIVLAEDGKKMSKRLKNYPDPTLIMQRYGSDA 620
Cdd:PRK13208 478 EDLFEKVFPMDLRPQGHDIIRTWlFY--TILRAYlLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEKYGADA 555
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 621 LRLYLINSPVvrAEPLRFKESGVKeiVAKVLL-PLWNSYKFfegqAALFKKNNSIDfvfdpKAEATNTnvMDRWILASCQ 699
Cdd:PRK13208 556 VRYWAASARL--GSDTPFDEKQVK--IGRRLLtKLWNASRF----VLHFSADPEPD-----KAEVLEP--LDRWILAKLA 620
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 700 SLLKFVNEEMAGYRLYtvvpRLLELIDNTTnW------YIRFNRKRLKGENGIDDTLHALNTLFEVLYTLVRGLAPFTPF 773
Cdd:PRK13208 621 KVVEKATEALENYDFA----KALEEIESFF-WhvfcddYLELVKSRAYGEDEEEEQKSARYTLYTVLDTLLRLLAPFLPF 695
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 774 ITDTIYQKLlahipqalrgeDSRSVHFLPFPEVREELFDEVVERRVARMQKVIEMARVSRERRSIGLKSPLKTLVVIHQD 853
Cdd:PRK13208 696 ITEEVWSWL-----------YGGSVHRASWPEPDEELIDEEDEELGELAKEILSAVRKYKSEAGLSLNAPLKKVEVYGPA 764
|
890 900 910
....*....|....*....|....*....|....*
gi 1832834855 854 qqYLDDVKSLEGYILEELNVLELVLSSDEAKYNVQ 888
Cdd:PRK13208 765 --DLELLEAAEEDLKAAGNIEELELVEGDPELEVE 797
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
638-830 |
6.44e-84 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 269.42 E-value: 6.44e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 638 FKESGVKEIVAKVLLPLWNSYKFFEGQAALFKKNNSIDFVFDPKaeatnTNVMDRWILASCQSLLKFVNEEMAGYRLYTV 717
Cdd:cd07961 1 FSEKGVREVVRKVLLPLWNAYRFFVTYANLDGFDPGKDDDAVAS-----LNVLDRWILSRLNSLIKEVTEEMEAYDLYTA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 718 VPRLLELIDNTTNWYIRFNRKRLKGENGIDDTLHALNTLFEVLYTLVRGLAPFTPFITDTIYQKLLAHIPqalrgEDSRS 797
Cdd:cd07961 76 VRALLEFIDELTNWYIRRNRKRFWGEEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRRELG-----DAPES 150
|
170 180 190
....*....|....*....|....*....|...
gi 1832834855 798 VHFLPFPEVREELFDEVVERRVARMQKVIEMAR 830
Cdd:cd07961 151 VHLLDWPEVDESLIDEELEEAMELVREIVELGR 183
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
35-175 |
6.93e-83 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 272.95 E-value: 6.93e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 35 YTFYDGPPFATGLPHYGHLLASTIKDIIPRYWSMKGHYVERRFGWDTHGVPIEYEIDKKLGMSGLEAVEKLGIEKYNEEC 114
Cdd:cd00818 3 FVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFNAKC 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1832834855 115 RAIVMRFASEWRETIERLGRWIDFDNDYKTMNSSFMESVWWVFKQLFDKGLVYRGYRVMPY 175
Cdd:cd00818 83 REFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW 143
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
14-911 |
1.06e-63 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 233.07 E-value: 1.06e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 14 KRWREINAFGRQvelSRGRKPYTFYDGPPFATGLPHYGHLLASTIKDIIPRYWSMKGH---YVerrFGWD-----THGVp 85
Cdd:PRK05729 20 QKWEEKGYFKPD---DNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYntlWL---PGTDhagiaTQMV- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 86 ieyeIDKKLGMSGLEAvEKLGIEKYNEEcraiVMrfasEWRE----TI----ERLGRWIDFDNDYKTMNSSFMESVWWVF 157
Cdd:PRK05729 93 ----VERQLAAEGKSR-HDLGREKFLEK----VW----EWKEesggTItnqlRRLGASCDWSRERFTMDEGLSKAVREVF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 158 KQLFDKGLVYRGYRVMPYSTALNTPLSNFEAqqNYKDVQDPAVVVSFPLVDDPETCLLAwTTTPWTLPSNVALAVNPGfe 237
Cdd:PRK05729 160 VRLYEKGLIYRGKRLVNWDPKLQTALSDLEV--EYKEVKGKLWHIRYPLADGSDYLVVA-TTRPETMLGDTAVAVNPE-- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 238 yikifDEaskkhyillesllRtlYKD--PKKAKFKIVDRfkgvdmkdwkyqplfdyfyeEFKdygfrVINGDYVSAEDGT 315
Cdd:PRK05729 235 -----DE-------------R--YKHliGKTVILPLVGR--------------------EIP-----IIADEYVDPEFGT 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 316 GIVHQSPAFGEEDYNVAMasgvisetR--LP-PNPVDEKGCFTAEVRDFVGQHVKAADKAIIKHLKGIGRLIVDSQITHS 392
Cdd:PRK05729 270 GAVKITPAHDPNDFEVGK--------RhnLPmINIMDEDGTINENPGEYQGLDRFEARKAIVADLEELGLLVKIEPHTHS 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 393 YPFCWRSDTPLIYRAVPSWFVKIGPIIPQMLQGIEESHwvPSFVKER---RFASWIQNARDWNISRNRFWGTPLPLWVSD 469
Cdd:PRK05729 342 VGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVENGE--IKFVPERwekTYFHWMENIQDWCISRQLWWGHRIPAWYDE 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 470 DFKEVVAVgsveelkqlsgyegeitdlhrdkvdkiTIPSKQGKGVLRRVSEVFDCWFESGSMPYASQHYPfENKEQFEKS 549
Cdd:PRK05729 420 DGEVYVGR---------------------------EEPEAREKALLTQDEDVLDTWFSSALWPFSTLGWP-EKTEDLKRF 471
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 550 FPGD----------FiaegldqtrgWFYTLTVLGTHLFGTLPFKNCVVNGIVLAEDGKKMSKRLKNYPDPTLIMQRYGSD 619
Cdd:PRK05729 472 YPTSvlvtgfdiifF----------WVARMIMMGLHFTGQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGAD 541
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 620 ALRLYLINSpvvrAEP---LRFKES---GVKEIVAKvllpLWNsykffegqAALFKKNNSIDFVFDPKAEATNTNVMDRW 693
Cdd:PRK05729 542 ALRFTLAAL----ASPgrdIRFDEErveGYRNFANK----LWN--------ASRFVLMNLEGADVGELPDPEELSLADRW 605
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 694 ILASCQSLLKFVNEEMAGYRLYTVVPRLLELIDNT-TNWYIRFNRKRLKGEngidDTLHALNTLFEVLYTLVRGLAPFTP 772
Cdd:PRK05729 606 ILSRLNRTVAEVTEALDKYRFDEAARALYEFIWNEfCDWYLELAKPVLQEA----AKRATRATLAYVLEQILRLLHPFMP 681
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 773 FITDTIYQKLlahipQALRGEDSRSVHflPFPEVREELfDEVVERRVARMQKVIEMARVSRERRSIGLKSPLKtLVVIHQ 852
Cdd:PRK05729 682 FITEELWQKL-----APLGIEESIMLA--PWPEADEAI-DEAAEAEFEWLKELITAIRNIRAEMNIPPSKKLP-LLLKGA 752
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1832834855 853 DQQYLDDVKSLEGYI--LEELNVLELVLSSDEAKYNVQYSVSADW----PTLG--------KKLKKDAQKVKK 911
Cdd:PRK05729 753 DAEDRARLEANEAYIkrLARLESLEILADDEEAPEGAASAVVGGAelflPLEGlidveaelARLEKELAKLEK 825
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
14-926 |
1.39e-63 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 232.63 E-value: 1.39e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 14 KRWREINAFgrQVELSRGRKPYTFYDGPPFATGLPHYGHLLASTIKDIIPRYWSMKGHyverrfgwDTHGVP------IE 87
Cdd:COG0525 18 QYWEENGYF--KADPDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGY--------NTLWQPgtdhagIA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 88 YEI--DKKLGMSGLEAvEKLGIEKYNEECRaivmrfasEWRE----TI----ERLGRWIDFDNDYKTMNSSFMESVWWVF 157
Cdd:COG0525 88 TQAvvERQLAEEGKSR-HDLGREKFLERVW--------EWKEesggTItnqlRRLGASCDWSRERFTMDEGLSKAVREVF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 158 KQLFDKGLVYRGYRVMPYSTALNTPLSNFEAqqNYKDVQDPAVVVSFPLVDDPETCLLAwTTTPWTLPSNVALAVNPGfe 237
Cdd:COG0525 159 VRLYEKGLIYRGKRLVNWDPKLKTALSDLEV--EHEEVKGHLWHIRYPLADGSGYIVVA-TTRPETMLGDTAVAVHPE-- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 238 yikifDEAsKKHYIllesllrtlykdPKKAKFKIVDRfkgvdmkdwkyqplfdyfyeEFKdygfrVINGDYVSAEDGTGI 317
Cdd:COG0525 234 -----DER-YKHLI------------GKTVILPLVGR--------------------EIP-----IIADEYVDPEFGTGA 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 318 VHQSPAFGEEDYNVAMASGvisetrLP-PNPVDEKGCFTAEVRDFVGQHVKAADKAIIKHLKGIGRLI-VDSqITHSYPF 395
Cdd:COG0525 271 VKITPAHDPNDFEVGKRHN------LPmINILDEDGTINENAGKYRGLDRFEARKAIVADLEELGLLVkVEP-HKHSVGH 343
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 396 CWRSDT---PLIyravpS--WFVKIGPIIPQMLQGIEESHwvPSFVKER---RFASWIQNARDWNISRNRFWGTPLPLWV 467
Cdd:COG0525 344 SDRSGTviePYL-----SdqWFVKMKPLAKPAIEAVEDGE--IKFVPERwekTYFHWMENIRDWCISRQLWWGHRIPAWY 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 468 SDDFKEVVAVGSVEELKQLSGyegeiTDLHRDKvDkitipskqgkgvlrrvseVFDCWFESGSMPYASQHYPFENKEqFE 547
Cdd:COG0525 417 CPDGEVYVARTEPEACAKAGS-----VNLTQDE-D------------------VLDTWFSSALWPFSTLGWPEKTED-LK 471
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 548 KsfpgdfiaegldqtrgwFYTLTVL-----------------GTHLFGTLPFKNCVVNGIVLAEDGKKMSKRLKNYPDPT 610
Cdd:COG0525 472 Y-----------------FYPTSVLvtgfdiiffwvarmimmGLHFTGEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPL 534
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 611 LIMQRYGSDALRLYLINSpvvrAEP---LRFKESGV--------KeivakvllpLWNsykffegqAALFKKNNSIDFVFD 679
Cdd:COG0525 535 DLIDKYGADALRFTLAAL----ASPgrdIKFDEERVegyrnfanK---------LWN--------ASRFVLMNLEGFDPG 593
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 680 PKAEATNTNVMDRWILASCQSLLKFVNEEMAGYRLYTVVPRLLELIDNT-TNWYIRFNRKRLKGENGIDDtLHALNTLFE 758
Cdd:COG0525 594 LDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVWNEfCDWYLELAKPRLYGGDEAAK-RETRATLVY 672
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 759 VLYTLVRGLAPFTPFITDTIYQkllaHIPQALRGEdsrSVHFLPFPEVREELFDEVVERRVARMQKVIEMARVSRERRSI 838
Cdd:COG0525 673 VLEQILRLLHPFMPFITEEIWQ----KLPPRKEGE---SIMLAPWPEADEELIDEEAEAEFEWLKEVISAIRNIRAEMNI 745
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 839 GLKSPLKtLVVIHQDQQYLDDVKSLEGYI-----LEELNVLE-------LVLSSDEAKYNVQYSVSADWPTLGKKLKKDA 906
Cdd:COG0525 746 PPSKKLP-LLLKGADEADRARLEENAAYIkrlarLEEITILVdekpegaASAVVGGAEVFLPLEGLIDVEAERARLEKEL 824
|
970 980
....*....|....*....|...
gi 1832834855 907 QKVKKALPSLT---SDdvKKFVA 926
Cdd:COG0525 825 AKLEKEIARVEkklSN--EGFVA 845
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
16-844 |
2.31e-63 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 234.12 E-value: 2.31e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 16 WREINAFgRQVELSRGRKPYTFYDGPPFATGLPHYGHLLASTIKDIIPRYWSMKGHYVERRFGWDTHGVPIEYEIDKKLG 95
Cdd:PRK14900 32 WQERGYF-HGDEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIATQMIVEKELK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 96 MSGLEAVEKLGIEKYNEECRAIVMRFASEWRETIERLGRWIDFDNDYKTMNSSFMESVWWVFKQLFDKGLVYRGYRVMPY 175
Cdd:PRK14900 111 KTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHEEGLIYREKKLINW 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 176 STALNTPLSNFEAQQNyKDVQDPAVVVSFPLVDDPETCLLAwTTTPWTLPSNVALAVNPgfeyikiFDEaskkHYILLES 255
Cdd:PRK14900 191 CPDCRTALSDLEVEHE-EAHQGELWSFAYPLADGSGEIVVA-TTRPETMLGDTAVAVHP-------LDP----RYMALHG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 256 llrtlykdpKKAKFKIVDRfkgvdmkdwkyqplfdyfyeEFKdygfRVINGDYVSAEDGTGIVHQSPAFGEEDYNVAMAS 335
Cdd:PRK14900 258 ---------KKVRHPITGR--------------------TFP----IVADAILVDPKFGTGAVKVTPAHDFNDFEVGKRH 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 336 GVISETRLppnpvDEKGCFTAEVRDFVGQHVKAADKAIIKHLKGIGrlIVDSQITHSYPF--CWRSDTPLIYRAVPSWFV 413
Cdd:PRK14900 305 GLEMITVI-----GPDGRMTAEAGPLAGLDRFEARKEVKRLLAEQG--LDRGAKPHVLPLgrCQRSATILEPLLSDQWYV 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 414 KIGPIIPQMLQGIEESHwvPSFVKER---RFASWIQNARDWNISRNRFWGTPLPLWVSDDFKEVVAVGSVEELkqlsgye 490
Cdd:PRK14900 378 RIEPLARPAIEAVEQGR--TRFIPEQwtnTYMAWMRNIHDWCISRQLWWGHQIPAWYCPDGHVTVARETPEAC------- 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 491 geitdlhrdkvdkitipSKQGKGVLRRVSEVFDCWFESGSMPYASQHYPfENKEQFEKSFPGDFIAEGLDQTRGWFYTLT 570
Cdd:PRK14900 449 -----------------STCGKAELRQDEDVLDTWFSSGLWPFSTMGWP-EQTDTLRTFYPTSVMETGHDIIFFWVARMM 510
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 571 VLGTHLFGTLPFKNCVVNGIVLAEDGKKMSKRLKNYPDPTLIMQRYGSDALRLYLInSPVVRAEPLRFKE---SGVKEIV 647
Cdd:PRK14900 511 MMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLA-ALTAQGRDIKLAKeriEGYRAFA 589
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 648 AKvllpLWNSYKFfegqaALFkknNSIDFVFD--PKAEATNTnVMDRWILASCQSLLKFVNEEMAGYRLYTVVPRLLELI 725
Cdd:PRK14900 590 NK----LWNASRF-----ALM---NLSGYQERgeDPARLART-PADRWILARLQRAVNETVEALEAFRFNDAANAVYAFV 656
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 726 -DNTTNWYIRFNRKRLKGEN-GIDDTLHAlnTLFEVLYTLVRGLAPFTPFITDTIYQKLLAHIpQALRGEDsrSVHFLPF 803
Cdd:PRK14900 657 wHELCDWYIELAKEALASEDpEARRSVQA--VLVHCLQTSYRLLHPFMPFITEELWHVLRAQV-GASAWAD--SVLAAEY 731
|
810 820 830 840
....*....|....*....|....*....|....*....|.
gi 1832834855 804 PEVREelFDEVVERRVARMQKVIEMARVSRERRSIGLKSPL 844
Cdd:PRK14900 732 PRKGE--ADEAAEAAFRPVLGIIDAVRNIRGEMGIPWKVKL 770
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
15-939 |
1.95e-57 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 215.64 E-value: 1.95e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 15 RWREINAFGRQVELS---RGRKPYTFYDGPPFATGLPHYGHLLASTIKDIIPRYWSMKGHYVERRFGWDTHGVPIEYEID 91
Cdd:PTZ00419 39 EWWEKSGFFKPAEDAkslNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGIATQVVVE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 92 KKLGMSGLEAVEKLGIEKYNEECRAIVMRFASEWRETIERLGRWIDFDNDYKTMNSSFMESVWWVFKQLFDKGLVYRGYR 171
Cdd:PTZ00419 119 KKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVKEAFVRLYEDGLIYRDTR 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 172 VMPYSTALNTPLSNFEAqqNYKDVQDPAVV----------------VSFPLVDDPETCLLAWTTTPWTLPSNVALAVNPg 235
Cdd:PTZ00419 199 LVNWCCYLKTAISDIEV--EFEEIEKPTKItipgydkkvevgvlwhFAYPLEDSGQEEIVVATTRIETMLGDVAVAVHP- 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 236 feyikifDEASKKHYIllesllrtlykdpkkAKFKIvdrfkgvdmkdwkyQPLfdyfyeeFKDYGFRVINGD-YVSAEDG 314
Cdd:PTZ00419 276 -------KDERYKKLH---------------GKELI--------------HPF-------IPDRKIPIIADDeLVDMEFG 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 315 TGIVHQSPAFGEEDYNVAMASGvisetrLPP-NPVDEKGCFTAEVRDFVGQHVKAADKAIIKHLKGIGrLIVDsQITHSY 393
Cdd:PTZ00419 313 TGAVKITPAHDPNDYEIAKRHN------LPFiNIFTLDGKINENGGEFAGMHRFDCRRKIEEELKEMG-LLRD-KVPNPM 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 394 --PFCWRSDTPLIYRAVPSWFVKIGPIIPQMLQGIE--ESHWVPSFvKERRFASWIQNARDWNISRNRFWGTPLP----- 464
Cdd:PTZ00419 385 rlPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAVRngELKIIPSS-HENVWYHWLENIQDWCISRQLWWGHRIPayrvi 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 465 ------------LWV-SDDFKEvvavgSVEELKQLSGYEGEITDLHRDkvdkitipskqgkgvlrrvSEVFDCWFESGSM 531
Cdd:PTZ00419 464 skgpetdpsdeePWVvARSEEE-----ALEKAKKKFGLSEEDFELEQD-------------------EDVLDTWFSSGLF 519
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 532 PYASQHYPfENKEQFEKSFPGDFIAEGLDQTRGWFYTLTVLGTHLFGTLPFKNCVVNGIVLAEDGKKMSKRLKNYPDP-- 609
Cdd:PTZ00419 520 PFSTLGWP-DQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPle 598
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 610 --------TLIMQRY---------------------------GSDALRL----YLINSPVVRAEplrfkesgVKEIVAKV 650
Cdd:PTZ00419 599 viegislqDLNQKLYegnlpekeikraielqkkefpngipecGTDALRFgllaYTQQGRNINLD--------INRVVGYR 670
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 651 LL--PLWNSYKFFEGQaALFKKNNSIDFVFDPkAEATNTNVMDRWILASCQSLLKFVNEEMAGYRLYTVVPR-----LLE 723
Cdd:PTZ00419 671 HFcnKLWNAVKFALMK-LLKDFNLPNSTLFKP-NNVESLPWEDKWILHRLNVAIKEVTEGFKEYDFSEATQAtynfwLYE 748
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 724 LIDnttnWYIRFNRKRLKGENGIDDTLHALNTLFEVLYTLVRGLAPFTPFITDTIYQKLlahiPQALRGEDSRSVHflPF 803
Cdd:PTZ00419 749 LCD----VYLELIKPRLSKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRL----PNYLRKSESISIA--KY 818
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 804 PEVREELFDEVVERRVARMQKVIEMARVSRERRSIGLKSPLKTLVVIHqDQQYLDDVKSLEGYI--LEELNVLELVLSSD 881
Cdd:PTZ00419 819 PQPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAK-DAELIELIESAENLIstLAKIGSVSVIPPIE 897
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 882 EAK----------------YNVQYSVSADWPTLGKKLKKDAQKVKKALPSL---TSD---------DVKK--------FV 925
Cdd:PTZ00419 898 EEAevpkgcgfdvvdnkviIYLNLDEFIDLKKELAKLEKKLAKLQKSLESYlkkISIpnyedkvpeDVRKlndekideLN 977
|
1050
....*....|....
gi 1832834855 926 AEKKMLVDGIELVE 939
Cdd:PTZ00419 978 EEIKQLEQAIEELK 991
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
2-782 |
7.37e-56 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 210.57 E-value: 7.37e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 2 SIDFPAEEEITlkRWREINAFGRQvELSRGRKPYTFYDGPPFATGLPHYGHLLASTIKDIIPRYWSMKGHYVERRFGWDT 81
Cdd:PLN02943 60 SFDFTSEERIY--NWWESQGYFKP-NFDRGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDH 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 82 HGVPIEYEIDKKLGMSGLEAVEkLGIEKYNEEcraivmrfASEWRET--------IERLGRWIDFDNDYKTMNSSFMESV 153
Cdd:PLN02943 137 AGIATQLVVEKMLASEGIKRTD-LGRDEFTKR--------VWEWKEKyggtitnqIKRLGASCDWSRERFTLDEQLSRAV 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 154 WWVFKQLFDKGLVYRGYRVMPYSTALNTPLSNFEAQqnYKDVQDPAVVVSFPLVDDPETCLLAWTTTPWTLPSNVALAVN 233
Cdd:PLN02943 208 VEAFVRLHEKGLIYQGSYMVNWSPNLQTAVSDLEVE--YSEEPGTLYYIKYRVAGGSEDFLTIATTRPETLFGDVAIAVN 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 234 PgfeyikifdeaskkhyillesllrtlyKDPKKAKFkiVDRFKGVDMKDWKYQPlfdyfyeefkdygfrVINGDYVSAED 313
Cdd:PLN02943 286 P---------------------------EDDRYSKY--IGKMAIVPMTYGRHVP---------------IIADRYVDKDF 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 314 GTGIVHQSPAFGEEDYNVAMASGvisetrLPPNPVDEKgcfTAEVRDFVGQHVKAADKAIIKHLKGIGRLIVDSQITHSY 393
Cdd:PLN02943 322 GTGVLKISPGHDHNDYLLARKLG------LPILNVMNK---DGTLNEVAGLYWFEAREKLWSDLEETGLAVKKEPHTLRV 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 394 PFCWRSDT---PLIYRavpSWFVKIGPIIPQMLQGIE--ESHWVPSFVkERRFASWIQNARDWNISRNRFWGTPLPLW-- 466
Cdd:PLN02943 393 PRSQRGGEviePLVSK---QWFVTMEPLAEKALKAVEngELTIIPERF-EKIYNHWLSNIKDWCISRQLWWGHRIPVWyi 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 467 VSDDFKE--VVAVGSVEELKQLSGYEGEITDLHRDkvdkitipskqgkgvlrrvSEVFDCWFESGSMPYASQHYPFENKE 544
Cdd:PLN02943 469 VGKDCEEdyIVARSAEEALEKAREKYGKDVEIYQD-------------------PDVLDTWFSSALWPFSTLGWPDVSAE 529
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 545 QFEKSFPGDFIAEGLDQTRGWFYTLTVLGTHLFGTLPFKNCVVNGIVLAEDGKKMSKRLKNYPDPTLIMQRYGSDALRLY 624
Cdd:PLN02943 530 DFKKFYPTTVLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFT 609
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 625 LINSPVVRAEPLRFKE-SGVKEIVAKvllpLWNSYKF----FEGQAALFKKNNSIDFVFDPKAEATNTNVMDRWILASCQ 699
Cdd:PLN02943 610 LALGTAGQDLNLSTERlTSNKAFTNK----LWNAGKFvlqnLPSQSDTSAWEHILACKFDKEESLLSLPLPECWVVSKLH 685
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 700 SLLKFVNEEMAGYrLYTVVPRllELID----NTTNWYIRFNRKRLKGENGIDDTLHALNTLFEVLYTLVRGLAPFTPFIT 775
Cdd:PLN02943 686 ELIDSVTTSYDKY-FFGDVGR--EIYDffwsDFADWYIEASKTRLYHSGDNSALSRAQAVLLYVFENILKLLHPFMPFVT 762
|
....*..
gi 1832834855 776 DTIYQKL 782
Cdd:PLN02943 763 EELWQAL 769
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
41-628 |
2.95e-47 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 173.97 E-value: 2.95e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 41 PPFATGLPHYGHLLASTIKDIIPRYWSMKGHYVERRFGWDTHGVPIEYEIDKKLGMSGLEAvEKLGIEKYNEECRAIVMR 120
Cdd:cd00817 9 PPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTR-HDLGREEFLEKCWEWKEE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 121 FASEWRETIERLGRWIDFDNDYKTMNSSFMESVWWVFKQLFDKGLVYRGYRVMPYSTALNTPLSNFEAQQNYKDVQDPAV 200
Cdd:cd00817 88 SGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEVCSRSGDVIEPLL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 201 vvsfplvddpetcllawtTTPWtlpsnvalavnpgfeYIKIFDEASKkhyillesllrtlykdpkkakfkivdrfkgvdm 280
Cdd:cd00817 168 ------------------KPQW---------------FVKVKDLAKK--------------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 281 kdwkyqplfdyfyeefkdygfrvingdyvsaedgtgivhqspafgeedynvamasgvisetrlppnpvdekgcftaevrd 360
Cdd:cd00817 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 361 fvgqHVKAADKAIIKhlkgigrlivdsqithsypfcwrsdtpliyravpswfvkigpIIPqmlqgieeSHWvpsfvkERR 440
Cdd:cd00817 182 ----ALEAVKEGDIK------------------------------------------FVP--------ERM------EKR 201
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 441 FASWIQNARDWNISRNRFWGTPLPLWVSDDFKEVVAVGSVEELKQLSGYEGEItdlhrdkvdkitipsKQGKGVLRRVSE 520
Cdd:cd00817 202 YENWLENIRDWCISRQLWWGHRIPAWYCKDGGHWVVAREEDEAIDKAAPEACV---------------PCGGEELKQDED 266
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 521 VFDCWFESGSMPYASQHYPfENKEQFEKSFPGDFIAEGLDQTRGWFYTLTVLGTHLFGTLPFKNCVVNGIVLAEDGKKMS 600
Cdd:cd00817 267 VLDTWFSSSLWPFSTLGWP-EETKDLKKFYPTSLLVTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMS 345
|
570 580
....*....|....*....|....*...
gi 1832834855 601 KRLKNYPDPTLIMQRYGSDALRLYLINS 628
Cdd:cd00817 346 KSLGNVIDPLDVIDGYGADALRFTLASA 373
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
403-626 |
2.87e-45 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 166.05 E-value: 2.87e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 403 LIY------RAVPSWFVKIGPIIPQMLQGIEESHWVPSFVKERrFASWIQNARDWNISRNRFWGTPLPLWVsddfkevva 476
Cdd:cd00668 128 LIYrgthpvRITEQWFFDMPKFKEKLLKALRRGKIVPEHVKNR-MEAWLESLLDWAISRQRYWGTPLPEDV--------- 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 477 vgsveelkqlsgyegeitdlhrdkvdkitipskqgkgvlrrvsevFDCWFESGSMPYASQHYPFENKEqFEKSFPGDFIA 556
Cdd:cd00668 198 ---------------------------------------------FDVWFDSGIGPLGSLGYPEEKEW-FKDSYPADWHL 231
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 557 EGLDQTRGWFYTLTVLGTHLFGTLPFKNCVVNGIVLAEDGKKMSKRLKNYPDPTLIMQRYGSDALRLYLI 626
Cdd:cd00668 232 IGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKYGADALRYYLT 301
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
34-172 |
8.23e-38 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 144.48 E-value: 8.23e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 34 PYTFYDGPPFATGLPHYGHLLASTIKDIIPRYWSMKGHYVERRFGWDTHGVPIEYEIDKKLGMSGleavEKLGIEKYNEE 113
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKK----KTIWIEEFRED 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1832834855 114 CRAIVMRFASEWRETIERLGRWIDFDNDYKTMNSSFMESVWWVFKQLFDKGLVYRGYRV 172
Cdd:cd00668 77 PKEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHP 135
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
32-883 |
4.72e-28 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 122.70 E-value: 4.72e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 32 RKPYTFYDGPPFATGLPHYGHLLASTIKDIIPRYWSMKGHYVERRFGWDTHGVPIEYEIDKKLGMSGLEAVEKLGIEKYN 111
Cdd:PLN02381 127 KPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIATQVVVEKKLMRERHLTRHDIGREEFV 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 112 EEcraiVMRFASEWRETI----ERLGRWIDFDNDYKTMNSSFMESVWWVFKQLFDKGLVYRGYRVMPYSTALNTPLSNFE 187
Cdd:PLN02381 207 SE----VWKWKDEYGGTIlnqlRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVE 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 188 AqqNYKDVQDP--------------AVVVSF--PLVDDPETCLLAwTTTPWTLPSNVALAVNPgfeyikifDEASKKHYi 251
Cdd:PLN02381 283 V--DYIDIKERtllkvpgydkpvefGVLTSFayPLEGGLGEIVVA-TTRIETMLGDTAIAIHP--------DDERYKHL- 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 252 llesllrtlykdpkKAKFKIvDRFKGVDMKdwkyqplfdyfyeefkdygfRVINGDYVSAEDGTGIVHQSPAFGEEDYNV 331
Cdd:PLN02381 351 --------------HGKFAV-HPFNGRKLP--------------------IICDAILVDPNFGTGAVKITPAHDPNDFEV 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 332 amasGVISETRLPPNPVDEKGCFTAEVRDFVGQHVKAADKAIIKHLKGIGRLIVDSQITHSYPFCWRSD---TPLIYrav 408
Cdd:PLN02381 396 ----GKRHNLEFINIFTDDGKINSNGGSEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNdvvEPMIK--- 468
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 409 PSWFVKIGPIIPQMLQGI--EESHWVPSFVK--ERRFASWIQNARDWNISRNRFWGTPLPLW---VSDDfkevvavgsve 481
Cdd:PLN02381 469 PQWFVNCSSMAKQALDAAidGENKKLEFIPKqyLAEWKRWLENIRDWCISRQLWWGHRIPAWyvtLEDD----------- 537
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 482 ELKQLSGYEGEITdLHRDKVDKITIPSKQGKGV---LRRVSEVFDCWFESGSMPYASQHYPfENKEQFEKSFPGDFIAEG 558
Cdd:PLN02381 538 QLKELGSYNDHWV-VARNESDALLEASQKFPGKkfeLSQDPDVLDTWFSSGLFPLSVLGWP-DDTDDLKAFYPTSVLETG 615
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 559 LDQTRGWFYTLTVLGTHLFGTLPFKNCVVNGIVLAEDGKKMSKRLKNYPDPTLIMQ------------------------ 614
Cdd:PLN02381 616 HDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINgisleglhkrleegnldpkelvva 695
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 615 -------------RYGSDALRLYLIN----SPVVRAEPLRFkeSGVKEIVAKvllpLWNSYKFfegqaALFKknnsIDFV 677
Cdd:PLN02381 696 kegqkkdfpngiaECGTDALRFALVSytaqSDKINLDILRV--VGYRQWCNK----LWNAVRF-----AMSK----LGDD 760
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 678 FDPKAeATNTNVMDrwilASCQSLLKFVNEEMAGyrlyTVVP-RLLELIDNTT---NW--------YIRFNRKRLKGENG 745
Cdd:PLN02381 761 YTPPA-TLSVETMP----FSCKWILSVLNKAISK----TVSSlDAYEFSDAAStvySWwqyqfcdvFIEAIKPYFAGDNP 831
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 746 --IDDTLHALNTLFEVLYTLVRGLAPFTPFITDTIYQKLlahiPQALRGEDSRSVHFLPFPEVREELFDEVVERRVARMQ 823
Cdd:PLN02381 832 efASERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQRL----PQPKDHTRKDSIMISEYPSAVEAWTNEKVEYEMDLVL 907
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1832834855 824 KVIEMARVSRERRSIGLKSPLKTLVVIHQDQQYLDDVKSLEGYI--LEELNVLELVLSSDEA 883
Cdd:PLN02381 908 STVKCLRSLRAEVLEKQKNERLPAFALCRNQEIAAIIKSHQLEIltLANLSSLKVLLSENDA 969
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
691-848 |
7.12e-28 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 109.80 E-value: 7.12e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 691 DRWILASCQSLLKFVNEEMAGYRLYTVVPRLLELIDNT-TNWYIRFNRKRLKGENGIDdtlHALNTLFEVLYTLVRGLAP 769
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDlSDWYLELIKDRLYGEEPDS---RAQTTLYEVLETLLRLLAP 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1832834855 770 FTPFITDTIYQKLlahipqalrgedsrSVHFLPFPEvREELFDEVVERRVARMQKVIEMARVSRERRSIGLKSPLKTLV 848
Cdd:pfam08264 78 FMPFITEELWQKE--------------SIHLAPWPE-DAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
48-945 |
2.82e-24 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 109.96 E-value: 2.82e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 48 PHYGHLLASTIKDIIPRYWSMKGHYVERRFGWDTHGVPIeyeidkkLGMSglEAV---EKLGIEKYNEECR--------- 115
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPI-------LGIA--ERIargDPETIELYKSLYGipeeelekf 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 116 ----AIVMRFASEWRETIERLGRWIDFDNDYKTMNSSFMESVWWVFKQLFDKGLVYRGYRVMPYSTALNTPLSNfeaqQN 191
Cdd:PRK12300 72 kdpeYIVEYFSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGD----HD 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 192 YKDVQDPA----VVVSFPlvDDPETCLLAWTTTPWTLPSNVALAVNPGFEYIKIfdEASKKHYILLESLLRTLyKDPKKa 267
Cdd:PRK12300 148 LLDGEEPEiveyTLIKFE--ESEDLILPAATLRPETIFGVTNLWVNPDATYVKA--EVDGEKWIVSKEAAEKL-SFQDR- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 268 KFKIVDRFKGVDMKDWKYQ-PLFDyfyEEFKdygfrVINGDYVSAEDGTGIVHQSPAFGEEDYnVAM--------ASGVI 338
Cdd:PRK12300 222 DVEIIEEIKGSELIGKKVKnPVTG---KEVP-----ILPADFVDPDNGTGVVMSVPAHAPYDY-VALrdlkknkeLLDVI 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 339 S-------------------ETRLPPNPVDE---------------KGCFTAEVRDFVGQHVKAADKAIIKHLKGIGRLI 384
Cdd:PRK12300 293 EpiplievegygefpakevvEKLGIKSQEDPeleeatkevyraefhKGVLKENTGEYAGKPVREAREKITKDLIEKGIAD 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 385 VDSQITHSYPFCwRSDTPLIYRAVP-SWFVKIGPiiP----QMLQGIEESHWVPSFVKeRRFASWIQNARDWNISRNRFW 459
Cdd:PRK12300 373 IMYEFSNRPVYC-RCGTECVVKVVKdQWFIDYSD--PewkeLAHKALDNMEIIPEEYR-KEFENTIDWLKDRACARRRGL 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 460 GTPLPL---WVsddfkevvavgsVEEL-------------KQLSGYEGEITDLHRDKVDKItipsKQGKGVLRRVSEvfd 523
Cdd:PRK12300 449 GTRLPWdeeWI------------IESLsdstiymayytiaHKIREYGIKPEQLTPEFFDYV----FLGKGDPEEVSK--- 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 524 cwfESGSMPYASQhypfENKEQFEKSFPGDFIAEGLDqtrgwfytltVLGTHLfgtlPF---------------KNCVVN 588
Cdd:PRK12300 510 ---KTGIPKEILE----EMREEFLYWYPVDWRHSGKD----------LIPNHL----TFfifnhvaifpeekwpRGIVVN 568
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 589 GIVLAEdGKKMSKRLKN-YPdptL--IMQRYGSDALRLYLINSpvvrAEPLR---FKESGVKEIvAKVLlplwnsYKFFE 662
Cdd:PRK12300 569 GFVLLE-GKKMSKSKGNvIP---LrkAIEEYGADVVRLYLTSS----AELLQdadWREKEVESV-RRQL------ERFYE 633
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 663 gqaaLFKKnnsidfvFDPKAEATNTNVMDRWILASCQSLLKFVNEEMAGYRLYTVVPRLLELIDNTTNWYIRfnrkRLKG 742
Cdd:PRK12300 634 ----LAKE-------LIEIGGEEELRFIDKWLLSRLNRIIKETTEAMESFQTRDAVQEAFYELLNDLRWYLR----RVGE 698
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 743 ENGiddtlhalNTLFEVLYTLVRGLAPFTPFITDTIYQKllahipqaLRGEDsrSVHFLPFPEVREELFDEVVERRVARM 822
Cdd:PRK12300 699 ANN--------KVLREVLEIWIRLLAPFTPHLAEELWHK--------LGGEG--FVSLEKWPEPDESKIDEEAELAEEYV 760
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 823 QKVIEMArvsRERRSIGLKSPLKTLVVIHQDQQYLDDVKSLEGYILEElnVLELVLSSDEAKYnvqysvsadwptLGKKL 902
Cdd:PRK12300 761 KRLIEDI---REILKVAKIKPKKVYIYVAPDWKYEVLEIAAENGDVKE--AIKELMKDEELRK------------HGKEV 823
|
970 980 990 1000
....*....|....*....|....*....|....*....|....*.
gi 1832834855 903 KKDAQKVKKALPSLTSDDVKKF---VAEKKMLVDGIELVEGDLVVK 945
Cdd:PRK12300 824 AKLAQKIVKEVLKLDKEVRKLIlknIDEEEVLEEAKDFLEKELGVE 869
|
|
| DUF5915 |
pfam19302 |
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of ... |
867-1010 |
3.60e-24 |
|
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of isoleucyl tRNA ligase enzymes.
Pssm-ID: 437134 [Multi-domain] Cd Length: 195 Bit Score: 101.01 E-value: 3.60e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 867 ILEELNVLELVLSSDEAKYnVQYSVSADWPTLGKKLKKDAQKVKKALPSLTSDDVKKfVAEKKML---VDG--IELVEGD 941
Cdd:pfam19302 4 IKEELNVKEVEFGADESEL-VEYSAKPNFPVLGKELGKLMKAAAKEIASLNQMEIQK-ILDGGTLtidVDGeeIELTSED 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1832834855 942 LVVKRGLKED--VASEGMepnadadvLTI-LDANLYPELAQQGLGREIINRLQRLRKKAGLVPTDDVRMEYA 1010
Cdd:pfam19302 82 LLVTRQGKEGlaVANEGT--------LTVaLDTTITEELREEGLVREIVSKIQNLRKESGFEVTDRINLYVS 145
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
654-782 |
2.63e-19 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 85.30 E-value: 2.63e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 654 LWNSYKFFEGQaalfkknnsIDFVFDPKAEATNTNVMDRWILASCQSLLKFVNEEMAGYRLYTVVPRLLELI-DNTTNWY 732
Cdd:cd07962 16 LWNAARFVLMN---------LEDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFwNDFCDWY 86
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1832834855 733 IRFNRKRLKGENGIDDtLHALNTLFEVLYTLVRGLAPFTPFITDTIYQKL 782
Cdd:cd07962 87 LELVKPRLYGEDEEEK-KAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
16-813 |
9.57e-17 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 85.65 E-value: 9.57e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 16 WREINAFG--RQVELSRGRK------PYtfydgpPFATGLpHYGHLLASTIKDIIPRYWSMKGHYVERRFGWDTHGVPIE 87
Cdd:PLN02563 93 WEENRTFRtpDDVDTSKPKFyvldmfPY------PSGAGL-HVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLPAE 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 88 -YEIDKklGMSGLEAVEKlgiekyNeecraiVMRFasewRETIERLGRWIDFDNDYKTMNSSFMESVWWVFKQLFDKGLV 166
Cdd:PLN02563 166 qYAIET--GTHPKITTLK------N------IARF----RSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLA 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 167 YRGYRVMPYSTALNTPLSNFEA-------------------------------QQNYKDVQDPAVV-------------- 201
Cdd:PLN02563 228 YQAEVPVNWCPALGTVLANEEVvdglsergghpvirkpmrqwmlkitayadrlLEDLDDLDWPESIkemqrnwigrsega 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 202 -VSFPLVD----DPETCLLAWTTTPWTLPSNVALAVNPGFEYIKIFDEASKKH----YILLES----LLRTlykDPKKAK 268
Cdd:PLN02563 308 eLDFSVLDgegkERDEKITVYTTRPDTLFGATYLVVAPEHPLLSSLTTAEQKEaveeYVDAASrksdLERT---ELQKEK 384
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 269 fkivdrfKGVDMKDWKYQPLfdyfyeefKDYGFRVINGDYVSAEDGTGIVHQSPAFGEEDYNVAMASGV-ISETRLPP-- 345
Cdd:PLN02563 385 -------TGVFTGSYAINPA--------TGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLpIKWVVKPAdg 449
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 346 NPVDEKGCFTAEVR---------DFVGQHVKAADKAIIKHLKGIGrlivdsqithsypfcwrsdtpliyravpswfvKIG 416
Cdd:PLN02563 450 NEDDAEKAYTGEGVivnssssglDINGLSSKEAAKKVIEWLEETG--------------------------------NGK 497
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 417 PIIPQMLqgieeshwvpsfvkerrfaswiqnaRDWNISRNRFWGTPLPLWVSDDFKEVVAVGSVE---ELKQLSGYE--- 490
Cdd:PLN02563 498 KKVNYKL-------------------------RDWLFARQRYWGEPIPVVFLEDSGEPVPVPESDlplTLPELDDFTptg 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 491 -GEiTDLHRDKVDKITIPSKQGKGVLRRVSEV----FDCWFesgsmpYASQHYPFENKEQFEKS-----FPGDFIAEG-- 558
Cdd:PLN02563 553 tGE-PPLAKAVSWVNTVDPSSGKPARRETNTMpqwaGSCWY------YLRFMDPKNSNALVDKEkekywMPVDLYVGGae 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 559 -----LDQTRGW---FYTLTVLGThlfgTLPFKnCVVN-GIVLAE---------DGK----------------------- 597
Cdd:PLN02563 626 havlhLLYARFWhkvLYDIGVVST----KEPFQ-CLVNqGMILGEveytafkdsDGEyvsadtadrlgelqqekipeekv 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 598 ----------------------KMSKRLKNYPDPTLIMQRYGSDALRLY-LINSPVVRAEPlrFKESGVkEIVAKVLLPL 654
Cdd:PLN02563 701 iksgdsfvlkddpsirliarahKMSKSRGNVVNPDDVVSEYGADSLRLYeMFMGPLRDSKT--WSTSGV-EGVHRFLGRT 777
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 655 WNsykFFEGQAALFKKNNSIDFVFDPKaeatntnvMDRWILASCQSLLKFVNEEMAGYRLYTVVPRLLELIDNTTNWYir 734
Cdd:PLN02563 778 WR---LVVGAPLPDGSFRDGTVVTDEE--------PSLEQLRLLHKCIAKVTEEIESTRFNTAISAMMEFTNAAYKWD-- 844
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1832834855 735 fNRKRlkgengiddtlhalntlfEVLYTLVRGLAPFTPFITDTIYQKlLAHipqalrgedSRSVHFLPFPEVREELFDE 813
Cdd:PLN02563 845 -KVPR------------------EAIEPFVLLLSPYAPHLAEELWFR-LGH---------SNSLAYEPWPEANPSYLVD 894
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
449-814 |
1.55e-15 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 81.64 E-value: 1.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 449 RDWNISRNRFWGTPLPLwVSDDFKEVVAVgSVEEL-------KQLSGYEGEITDLHRDKVdKITIPSKQGKGvlRRVSEV 521
Cdd:COG0495 420 RDWLISRQRYWGEPIPI-IHCEDCGVVPV-PEDQLpvelpedVDFDPTGGSPLARAPEWV-NVTCPKCGGPA--RRETDT 494
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 522 FDCWFESgS---MPYASQHY---PFeNKEQFEKSFPgdfiaegLDQ--------------TRgwFYT--LTVLGtHLFGT 579
Cdd:COG0495 495 MDTFVDS-SwyyLRYTDPHNdeaPF-DPEAANYWLP-------VDQyiggiehailhllyAR--FFTkvLRDLG-LVSFD 562
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 580 LPFKNCVVNGIV--LAEDGK------KMSKRLKNYPDPTLIMQRYGSDALRLYLI-NSPVVRAepLRFKESGVkEIVAKV 650
Cdd:COG0495 563 EPFKRLLTQGMVleVGKDGVviggieKMSKSKGNVVDPDEIIEKYGADTLRLFEMfAGPPERD--LEWSDSGV-EGAYRF 639
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 651 LLPLWnsykffegqaalfkkNNSIDFVFDPKAEATNTNVMDRWILASCQSLLKFVNEEMAGYRLYTVVPRLLELIdNTTN 730
Cdd:COG0495 640 LNRVW---------------RLVVDEAEALKLDVADLSEADKELRRALHKTIKKVTEDIERLRFNTAIAALMELV-NALY 703
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 731 wyirfnrkRLKGENGIDDTLhalntLFEVLYTLVRGLAPFTPFITDTIYQKLlahipqalrGEDSrSVHFLPFPEVREEL 810
Cdd:COG0495 704 --------KAKDSGEADRAV-----LREALETLVLLLAPFAPHIAEELWERL---------GHEG-SVADAPWPEADEAA 760
|
....*.
gi 1832834855 811 F--DEV 814
Cdd:COG0495 761 LveDEV 766
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
42-169 |
4.29e-13 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 71.51 E-value: 4.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 42 PFATGLPHYGHLLASTIKDIIPRYWSMKGHYVERRFGWDTHGVPIEyeidkklgmsglEAVEKLGIEKYNeecraIVMRF 121
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAE------------NAAIKIGRDPED-----WTEYN 71
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1832834855 122 ASEWRETIERLGRWIDFDNDYKTMNSSFMESVWWVFKQLFDKGLVYRG 169
Cdd:cd00812 72 IKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKK 119
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
42-184 |
2.99e-11 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 66.54 E-value: 2.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 42 PFATGLPHYGHLLASTIKDIIPRYWSMKGHYVerRF--GWDTHGVPIEyeidkklgmsgLEAvEKLGIEKyneecRAIVM 119
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDV--LFvcGTDEHGTPIE-----------LKA-EKEGITP-----EELVD 68
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1832834855 120 RFASEWRETIERLGrwIDFDNDYKTMNSSFMESVWWVFKQLFDKGLVYRGYRVMPYSTALNTPLS 184
Cdd:pfam09334 69 RYHEIHREDFKKFN--ISFDDYGRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLP 131
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
678-827 |
8.84e-11 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 61.77 E-value: 8.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 678 FDPKAEAT---NTNVMDRWILASCQSLLKFVNEEMAGYRLYTVVPRLLELIDNT-TNWYIRFNRKRLKGEnGIDDT--LH 751
Cdd:cd07960 30 FDPAKDAVpyeELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCTVDlSAFYLDIIKDRLYCD-AKDSLerRS 108
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1832834855 752 ALNTLFEVLYTLVRGLAPFTPFITDTIYQkllaHIPQALRGEdsrSVHFLPFPEVREELFDEVVErrvARMQKVIE 827
Cdd:cd07960 109 AQTVLYHILDALLKLLAPILPFTAEEVWE----HLPGEKKEE---SVFLEDWPELPEEWKDEELE---EKWEKLLA 174
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
42-192 |
1.06e-10 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 64.09 E-value: 1.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 42 PFATGLPHYGHLLASTIKDIIPRYWSMKGHYVerRF--GWDTHGVPIEyeidkklgmsgLEAvEKLGIEKyneecRAIVM 119
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDV--LFvtGTDEHGTKIE-----------QKA-EEEGVTP-----QELCD 69
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1832834855 120 RFASEWRETIERLGrwIDFDNDYKTMNSSFMESVWWVFKQLFDKGLVYRGYRVMPYSTALNTPLSNFEAQQNY 192
Cdd:cd00814 70 KYHEIFKDLFKWLN--ISFDYFIRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLPEWREEEHY 140
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
411-626 |
4.24e-10 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 62.27 E-value: 4.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 411 WFVKIGP--IIPQMLQGIEESHWVPSFVKeRRFASWIqnardwNISRNRFWGTPLPL-WVSDDFkevvaVGSveelkqlS 487
Cdd:cd00812 132 WFLKYSEteWKEKLLKDLEKLDGWPEEVR-AMQENWI------GCSRQRYWGTPIPWtDTMESL-----SDS-------T 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 488 GYEGEITDLHRDKVDKITIPSkqgkgvlrrvsevfdcwfesgsmpyasqhypfENKEQFEKSFPGDFIAEGLDQ-----T 562
Cdd:cd00812 193 WYYARYTDAHNLEQPYEGDLE--------------------------------FDREEFEYWYPVDIYIGGKEHapnhlL 240
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1832834855 563 RGWFYTLTVLGTHLFGTLPFKNCVVNGIVLAEdGKKMSKRLKNYPDPTLIMQRYGSDALRLYLI 626
Cdd:cd00812 241 YSRFNHKALFDEGLVTDEPPKGLIVQGMVLLE-GEKMSKSKGNVVTPDEAIKKYGADAARLYIL 303
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
42-169 |
5.97e-10 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 63.21 E-value: 5.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 42 PFATGLPHYGHLLASTIKDIIPRYWSMKGHYVerRF--GWDTHGVPIEyeidkklgmsgLEAvEKLGIekyneECRAIVM 119
Cdd:COG0143 10 PYANGPPHIGHLYTYIPADILARYQRLRGHDV--LFvtGTDEHGTKIE-----------LAA-EKEGI-----TPQELVD 70
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1832834855 120 RFASEWRETIERLGrwIDFDNDYKTMNSSFMESVWWVFKQLFDKGLVYRG 169
Cdd:COG0143 71 RIHAEFKELFEKLG--ISFDNFIRTTSPEHKELVQEIFQRLYDNGDIYKG 118
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
691-782 |
2.14e-07 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 50.67 E-value: 2.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 691 DRWILASCQSLLKFVNEEMAGYRLYTVVPRLLELIDNTTNWYirfnRKRLKGENGIDdtlhalnTLFEVLYTLVRGLAPF 770
Cdd:cd07959 37 DRWLLSRLNRLIKETTEAYENMQFREALKEGLYELQNDLDWY----RERGGAGMNKD-------LLRRFIEVWTRLLAPF 105
|
90
....*....|..
gi 1832834855 771 TPFITDTIYQKL 782
Cdd:cd07959 106 APHLAEEIWHEL 117
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
394-782 |
3.45e-07 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 54.35 E-value: 3.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 394 PFCWRSDTPLIYRAVPSWFVKIGPIIPQMLQGIEE-SHWVPSFVKERRfaSWIQNA-RDWNISRNRFWGTPLPlwvsddf 471
Cdd:COG0143 169 PRSAISGAPPELREEEHYFFRLSKYQDRLLEWIEEnPDIQPEVRNEVL--SWLKEGlQDLSISRDFDWGIPVP------- 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 472 kevvavgsveelkqlsGYEGeitdlHrdkvdkitipskqgkgvlrrvseVFDCWFE------SGSMPYASQHypfENKEQ 545
Cdd:COG0143 240 ----------------GDPG-----K-----------------------VFYVWFDaligyiSATKGYADDR---GLPED 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 546 FEKSFPGD------FIaeGLDQTRgwFYTL----TVLGTHLfgTLPfKNCVVNGIVLAEdGKKMSKRLKNYPDPTLIMQR 615
Cdd:COG0143 273 FEKYWPAPdtelvhFI--GKDIIR--FHAIiwpaMLMAAGL--PLP-KKVFAHGFLTVE-GEKMSKSRGNVIDPDDLLDR 344
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 616 YGSDALRLYLI-NSPvvRAEPLRFKEsgvKEIVAKVllplwNS-----------------YKFFEGQAalfkknnsidfv 677
Cdd:COG0143 345 YGPDALRYYLLrEVP--FGQDGDFSW---EDFVARV-----NSdlandlgnlasrtlsmiHKYFDGKV------------ 402
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 678 fdpkAEATNTNVMDRWILASCQSLLKFVNEEMAGYRLYTVVPRLLELIDnTTNWYIRFNR--KRLKGENgiDDTLHA-LN 754
Cdd:COG0143 403 ----PEPGELTEADEELLAEAEAALEEVAEAMEAFEFRKALEEIMALAR-AANKYIDETApwKLAKDED--PERLATvLY 475
|
410 420
....*....|....*....|....*...
gi 1832834855 755 TLFEVLYTLVRGLAPFTPFITDTIYQKL 782
Cdd:COG0143 476 TLLEALRILAILLKPFLPETAEKILEQL 503
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
394-782 |
5.70e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 53.35 E-value: 5.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 394 PFCWRSDTPLIYRAVPSWFVKIGPIIPQMLQGIEEShwvPSFV--KERR--FASWIQN-ARDWNISRNRF-WGTPLPlwv 467
Cdd:PRK11893 142 YRCPPTGAPVEWVEEESYFFRLSKYQDKLLELYEAN---PDFIqpASRRneVISFVKSgLKDLSISRTNFdWGIPVP--- 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 468 sDDFKEVVAVGsveeLKQLSGYegeitdlhrdkvdkITipskqgkGVLRrvsevfdcwfesgsmPYASQhypfENKEQFE 547
Cdd:PRK11893 216 -GDPKHVIYVW----FDALTNY--------------LT-------ALGY---------------PDDEE----LLAELFN 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 548 KSFPGD--FIaeGLDQTR----GWFYTLTVLGTHLFgtlpfKNCVVNG-IVLaeDGKKMSKRLKNYPDPTLIMQRYGSDA 620
Cdd:PRK11893 251 KYWPADvhLI--GKDILRfhavYWPAFLMAAGLPLP-----KRVFAHGfLTL--DGEKMSKSLGNVIDPFDLVDEYGVDA 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 621 LRLYLInSPVVRAEPLRFKESGVKEIVAKVL---LPLWNS------YKFFEGQAalfkknnsidfvfdPKAEATNTNvmD 691
Cdd:PRK11893 322 VRYFLL-REIPFGQDGDFSREAFINRINADLandLGNLAQrtlsmiAKNFDGKV--------------PEPGALTEA--D 384
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 692 RWILASCQSLLKFVNEEMAGYRLYTVVPRLLELIDNtTNWYIRFNR--KRLKGENGIDDTLhaLNTLFEVLYTLVRGLAP 769
Cdd:PRK11893 385 EALLEAAAALLERVRAAMDNLAFDKALEAILALVRA-ANKYIDEQApwSLAKTDPERLATV--LYTLLEVLRGIAVLLQP 461
|
410
....*....|...
gi 1832834855 770 FTPFITDTIYQKL 782
Cdd:PRK11893 462 VMPELAAKILDQL 474
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
678-771 |
8.29e-07 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 49.04 E-value: 8.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 678 FDPKAEATNTNVMDRWILASCQSLLKFVNEEMAGYRLYTVVPRLLELIdNTTNWYIRFNRKRLKGENGIDDTLHALNTLF 757
Cdd:cd07375 28 TQPKWDNELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFT-NELNWYLDELKPALQTEELREAVLAVLRAAL 106
|
90
....*....|....
gi 1832834855 758 EVLYTLvrgLAPFT 771
Cdd:cd07375 107 VVLTKL---LAPFT 117
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
404-626 |
1.06e-06 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 51.76 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 404 IYRAVPSWFVKIGPIIPQMLQGIEES---HWVPSFVKERRfaSWIQNA-RDWNISRNRF-WGTPLPLwvsddfkevvavg 478
Cdd:cd00814 133 EWREEEHYFFRLSKFQDRLLEWLEKNpdfIWPENARNEVL--SWLKEGlKDLSITRDLFdWGIPVPL------------- 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 479 sveelkqlsgyegeitdlHRDKVdkitipskqgkgvlrrvsevFDCWFE------SGSMpyasqhYPFENKEQFEKSFPG 552
Cdd:cd00814 198 ------------------DPGKV--------------------IYVWFDaligyiSATG------YYNEEWGNSWWWKDG 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 553 D-----FIaeGLDQTRgwFYTL----TVLGTHLfgTLPfKNCVVNGIVLAEdGKKMSKRLKNYPDPTLIMQRYGSDALRL 623
Cdd:cd00814 234 WpelvhFI--GKDIIR--FHAIywpaMLLGAGL--PLP-TRIVAHGYLTVE-GKKMSKSRGNVVDPDDLLERYGADALRY 305
|
...
gi 1832834855 624 YLI 626
Cdd:cd00814 306 YLL 308
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
42-168 |
1.31e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 52.46 E-value: 1.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 42 PFATGLPHYGHLLASTIKDIIPRYWSMKGH---YVerrFGWDTHGVPIEyeidkklgmsgLEAvEKLGIEKyneecRAIV 118
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHevlFV---CADDAHGTPIM-----------LKA-EKEGITP-----EELI 70
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1832834855 119 MRFASEWRETIERLGrwIDFDNDYKT---MNSSFMESvwwVFKQLFDKGLVYR 168
Cdd:PRK00133 71 ARYHAEHKRDFAGFG--ISFDNYGSThseENRELAQE---IYLKLKENGYIYE 118
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
394-629 |
4.56e-06 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 50.37 E-value: 4.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 394 PFCWRSDTPLIYRAVPSWFVKIGPIIPQMLQGIEESH--WVPSFVKERRfaSWIQNA-RDWNISRNRFWGTPLPlwvsdd 470
Cdd:pfam09334 167 PKCVICGTTPEVKETEHYFFDLSKFQDKLREWIEENNpeWPENVKNMVL--EWLKEGlKDRAISRDLDWGIPVP------ 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 471 fkevvavgsveelkqlsGYEGEitdlhrdkvdkitipskqgkgvlrrvseVFDCWFESgSMPY-ASQHYPFENKEQFEKS 549
Cdd:pfam09334 239 -----------------GAEGK----------------------------VFYVWLDA-PIGYiSATKELSGNEEKWKEW 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 550 FPGD-------FIaeGLDQTRgwFYTL----TVLGTHLfgTLPfKNCVVNGIVLAEdGKKMSKRLKNYPDPTLIMQRYGS 618
Cdd:pfam09334 273 WPNDpdtelvhFI--GKDIIY--FHTIfwpaMLLGAGY--RLP-TTVFAHGYLTYE-GGKMSKSRGNVVWPSEALDRFPP 344
|
250
....*....|..
gi 1832834855 619 DALRLYLI-NSP 629
Cdd:pfam09334 345 DALRYYLArNRP 356
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
538-626 |
8.36e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 46.72 E-value: 8.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 538 YPFENKEQFEKSFPGDFIAEGLDQTRgwFYT------LTVLGthlfgtLP-FKNCVVNGIVLAEDGKkMSKRLKNYPDPT 610
Cdd:PRK12267 241 YGSDDDELFKKFWPADVHLVGKDILR--FHAiywpimLMALG------LPlPKKVFAHGWWLMKDGK-MSKSKGNVVDPE 311
|
90
....*....|....*.
gi 1832834855 611 LIMQRYGSDALRLYLI 626
Cdd:PRK12267 312 ELVDRYGLDALRYYLL 327
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
433-782 |
4.86e-04 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 44.32 E-value: 4.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 433 PSFVKE----RRFASWIQNA-RDWNISRNRF-WGTPLPlwvsDDFKEVVAVGsveeLKQLSGYEGEITDLHRDKVDKITI 506
Cdd:PLN02224 245 PRFVQPsyrlNEVQSWIKSGlRDFSISRALVdWGIPVP----DDDKQTIYVW----FDALLGYISALTEDNKQQNLETAV 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 507 pskqgkgvlrrvsevfdcwfeSGSMPyASQHYPFENKEQFEKSF-PGDFIAEGLDQTRGWFytltvlgTHLFgtlpfknc 585
Cdd:PLN02224 317 ---------------------SFGWP-ASLHLIGKDILRFHAVYwPAMLMSAGLELPKMVF-------GHGF-------- 359
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 586 vvngivLAEDGKKMSKRLKNYPDPTLIMQRYGSDALRLYLINSPVVRAEPLRFKESGVKEIVAKVLLPLWNsykFFEGQA 665
Cdd:PLN02224 360 ------LTKDGMKMGKSLGNTLEPFELVQKFGPDAVRYFFLREVEFGNDGDYSEDRFIKIVNAHLANTIGN---LLNRTL 430
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832834855 666 ALFKKNNSIDFVFDPKAEATNTNVMDrwilaSCQSLLKFVNEEMAGYRLYTVVPRLLEL-------IDNTTNWYIrFNRK 738
Cdd:PLN02224 431 GLLKKNCESTLVEDSTVAAEGVPLKD-----TVEKLVEKAQTNYENLSLSSACEAVLEIgnagntyMDQRAPWFL-FKQG 504
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1832834855 739 RLKGENGIDDtlhaLNTLFEVLYTLVRGLAPFTPFITDTIYQKL 782
Cdd:PLN02224 505 GVSAEEAAKD----LVIILEVMRVIAVALSPIAPCLSLRIYSQL 544
|
|
| |
