CDK5 and ABL1 enzyme substrate 2 [Melopsittacus undulatus]
List of domain hits
Name | Accession | Description | Interval | E-value | |||
CYCLIN_CABLES2 | cd20603 | cyclin box found in CDK5 and ABL1 enzyme substrate 2 (CABLES2); CABLES2, also called ... |
376-496 | 2.80e-84 | |||
cyclin box found in CDK5 and ABL1 enzyme substrate 2 (CABLES2); CABLES2, also called interactor with CDK3 2 (Ik3-2), acts as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. CABLES2 contains one cyclin box. The cyclin box is a protein binding domain. : Pssm-ID: 410306 Cd Length: 121 Bit Score: 255.58 E-value: 2.80e-84
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Name | Accession | Description | Interval | E-value | |||
CYCLIN_CABLES2 | cd20603 | cyclin box found in CDK5 and ABL1 enzyme substrate 2 (CABLES2); CABLES2, also called ... |
376-496 | 2.80e-84 | |||
cyclin box found in CDK5 and ABL1 enzyme substrate 2 (CABLES2); CABLES2, also called interactor with CDK3 2 (Ik3-2), acts as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. CABLES2 contains one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410306 Cd Length: 121 Bit Score: 255.58 E-value: 2.80e-84
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CYCLIN | smart00385 | domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ... |
388-472 | 8.58e-05 | |||
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control. Pssm-ID: 214641 [Multi-domain] Cd Length: 83 Bit Score: 41.04 E-value: 8.58e-05
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Cyclin_N | pfam00134 | Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ... |
342-476 | 1.12e-03 | |||
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain. Pssm-ID: 459686 [Multi-domain] Cd Length: 127 Bit Score: 39.04 E-value: 1.12e-03
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Name | Accession | Description | Interval | E-value | |||
CYCLIN_CABLES2 | cd20603 | cyclin box found in CDK5 and ABL1 enzyme substrate 2 (CABLES2); CABLES2, also called ... |
376-496 | 2.80e-84 | |||
cyclin box found in CDK5 and ABL1 enzyme substrate 2 (CABLES2); CABLES2, also called interactor with CDK3 2 (Ik3-2), acts as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. CABLES2 contains one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410306 Cd Length: 121 Bit Score: 255.58 E-value: 2.80e-84
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CYCLIN_CABLES1 | cd20602 | cyclin box found in CDK5 and ABL1 enzyme substrate 1 (CABLES1); CABLES1, also called ... |
367-497 | 1.71e-74 | |||
cyclin box found in CDK5 and ABL1 enzyme substrate 1 (CABLES1); CABLES1, also called interactor with CDK3 1 (Ik3-1), is a cyclin-dependent kinase binding protein that enhances cyclin-dependent kinase tyrosine phosphorylation by non-receptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. CABLES1 contains one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410305 Cd Length: 132 Bit Score: 231.09 E-value: 1.71e-74
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CYCLIN_CABLES | cd20556 | cyclin box found in CDK5 and ABL1 enzyme substrate (CABLES) family; The CABLES family includes ... |
376-493 | 1.13e-60 | |||
cyclin box found in CDK5 and ABL1 enzyme substrate (CABLES) family; The CABLES family includes CABLES1 and CABLES2. CABLES1, also called interactor with CDK3 1 (Ik3-1), is a cyclin-dependent kinase binding protein that enhances cyclin-dependent kinase tyrosine phosphorylation by non-receptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. CABLES2, also called interactor with CDK3 2 (Ik3-2), acts as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. Both, CABLES1 and CABLES2, contain one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410259 Cd Length: 119 Bit Score: 194.71 E-value: 1.13e-60
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CYCLIN_SF | cd00043 | Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ... |
383-468 | 4.55e-08 | |||
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box. Pssm-ID: 410207 [Multi-domain] Cd Length: 82 Bit Score: 50.49 E-value: 4.55e-08
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CYCLIN | smart00385 | domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ... |
388-472 | 8.58e-05 | |||
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control. Pssm-ID: 214641 [Multi-domain] Cd Length: 83 Bit Score: 41.04 E-value: 8.58e-05
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Cyclin_N | pfam00134 | Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ... |
342-476 | 1.12e-03 | |||
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain. Pssm-ID: 459686 [Multi-domain] Cd Length: 127 Bit Score: 39.04 E-value: 1.12e-03
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CYCLIN_CCNM_CCNQ_rpt1 | cd20534 | first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ... |
388-443 | 3.63e-03 | |||
first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410237 [Multi-domain] Cd Length: 110 Bit Score: 37.15 E-value: 3.63e-03
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Blast search parameters | ||||
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