NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1868518112|ref|XP_035325758|]
View 

methyltransferase domain-containing protein [Colletotrichum scovillei]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 195-343 8.22e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam13489:

Pssm-ID: 473071 [Multi-domain]  Cd Length: 162  Bit Score: 48.96  E-value: 8.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868518112 195 ILDYGMRTGIWSIETADCVRHlhgrVVGYDIidMHPPMDILPENLTLVTGDDGKVWRKDSPYDIIHVRFV-ESIVDWQNF 273
Cdd:pfam13489  26 VLDFGCGTGIFLRLLRAQGFS----VTGVDP--SPIAIERALLNVRFDQFDEQEAAVPAGKFDVIVAREVlEHVPDPPAL 99

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868518112 274 PKIAYNNLNTGGRLIIEMVDLMpcGDEQKSFPGNSALkAWAEKFRQYIkcqaDQQEIEALLRDQGFDVTC 343
Cdd:pfam13489 100 LRQIAALLKPGGLLLLSTPLAS--DEADRLLLEWPYL-RPRNGHISLF----SARSLKRLLEEAGFEVVS 162
 
Name Accession Description Interval E-value
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 195-343 8.22e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 48.96  E-value: 8.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868518112 195 ILDYGMRTGIWSIETADCVRHlhgrVVGYDIidMHPPMDILPENLTLVTGDDGKVWRKDSPYDIIHVRFV-ESIVDWQNF 273
Cdd:pfam13489  26 VLDFGCGTGIFLRLLRAQGFS----VTGVDP--SPIAIERALLNVRFDQFDEQEAAVPAGKFDVIVAREVlEHVPDPPAL 99

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868518112 274 PKIAYNNLNTGGRLIIEMVDLMpcGDEQKSFPGNSALkAWAEKFRQYIkcqaDQQEIEALLRDQGFDVTC 343
Cdd:pfam13489 100 LRQIAALLKPGGLLLLSTPLAS--DEADRLLLEWPYL-RPRNGHISLF----SARSLKRLLEEAGFEVVS 162
 
Name Accession Description Interval E-value
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 195-343 8.22e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 48.96  E-value: 8.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868518112 195 ILDYGMRTGIWSIETADCVRHlhgrVVGYDIidMHPPMDILPENLTLVTGDDGKVWRKDSPYDIIHVRFV-ESIVDWQNF 273
Cdd:pfam13489  26 VLDFGCGTGIFLRLLRAQGFS----VTGVDP--SPIAIERALLNVRFDQFDEQEAAVPAGKFDVIVAREVlEHVPDPPAL 99

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868518112 274 PKIAYNNLNTGGRLIIEMVDLMpcGDEQKSFPGNSALkAWAEKFRQYIkcqaDQQEIEALLRDQGFDVTC 343
Cdd:pfam13489 100 LRQIAALLKPGGLLLLSTPLAS--DEADRLLLEWPYL-RPRNGHISLF----SARSLKRLLEEAGFEVVS 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH