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Conserved domains on  [gi|1868502967|ref|XP_035332960|]
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COPII coat assembly protein SEC16 [Colletotrichum scovillei]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sec16_C pfam12931
Sec23-binding domain of Sec16; Sec16 is a multi-domain vesicle coat protein. The C-terminal ...
 1151-1454 1.96e-142

Sec23-binding domain of Sec16; Sec16 is a multi-domain vesicle coat protein. The C-terminal region is the part that binds to Sec23, a COPII vesicle coat protein. This association is part of the transport vesicle coat structure.


:

Pssm-ID: 432884  Cd Length: 279  Bit Score: 442.77  E-value: 1.96e-142
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1151 IRKHLLVGDREKAVWEAADKRLWGHAMLISNTVSPDLYKQVAQEFVRKEVNYPG-HANESIAALYKVLSGNFDDCVDELV 1229
Cdd:pfam12931    1 IRALLLTGDREKALWLALDKKLWAHALLIASTLGKEKWKEVVQEFVRSEFKGSNnKSGESLAALYQVFAGNSEEAVDELV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1230 PAharagfqlvnttsasgsSKDATEGLDKWRETLGLVLSNRSTDDIRALNALGNLLSSYGRAEAAHICFLFARKatvfgg 1309
Cdd:pfam12931   81 PP-----------------SKNALWALDNWRETLALVLSNRSPGDVEALLALGDLLAQYGRTEAAHICFLLAGL------ 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1310 lddPASNFVLVGADHKTQGEQFAKETEALLLSEVYEYGLSLAGGPTLTVGVPHLAAYKLQHAMTLAEYGLRDKALQYCEA 1389
Cdd:pfam12931  138 ---PLSQTVLLGADHVRFPSTFGNDLESILLTEIYEYALSLSPPQPPFVGLPHLLPYKLQHAAVLAEYGLVSEAQKYCDA 214

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1868502967 1390 IASSINAQTKRSNYHHPILETAVENLRTRLRQAPKEESSSWISKPSMNKVSDTVWSRFNKFVAGD 1454
Cdd:pfam12931  215 ITASLKSLTKKSPYYHPTLLAQLEDLSNRLSQSPQGKSSSWISKPSLDKVWGQLDKSFNKFIAGD 279
Sec16 pfam12932
Vesicle coat trafficking protein Sec16 mid-region; Sec16 is a multi-domain vesicle coat ...
 972-1090 1.86e-57

Vesicle coat trafficking protein Sec16 mid-region; Sec16 is a multi-domain vesicle coat protein. This central region is the functional part of the molecules and thus is vital for the family's role in mediating the movement of protein-cargo between the organelles of the secretory pathway.


:

Pssm-ID: 432885  Cd Length: 119  Bit Score: 194.36  E-value: 1.86e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  972 APIISWGVGGTMVTSFPKNVPRYGMGQTAPMIIRSPGEVHVKHIKDTQPLEERLAKFPGPL-RGKSKKKETIAWLSSGID 1050
Cdd:pfam12932    1 HPIFSFGFGGKLVTMFPKRVPRYSTGQDVPMIKRSPGEVKIRNLKDVVPLSEDLAKFPGPLvKGKSKKKEVLKWLSERIE 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1868502967 1051 TLEKELPEvSFQPQLSHEHKRAIERLLLWKILRVFVEHDG 1090
Cdd:pfam12932   81 ELEQSLPY-SDGSLESDEKKRAEEKLLLWKLLKILVEHDG 119
Sec16_N super family cl28787
Vesicle coat trafficking protein Sec16 N-terminus; Sec16 is a multi-domain vesicle coat ...
 279-472 4.38e-13

Vesicle coat trafficking protein Sec16 N-terminus; Sec16 is a multi-domain vesicle coat protein. The overall function of Sec16 is in mediating the movement of protein-cargo between the organelles of the secretory pathway. Over-expression of truncated mutants of only the N-terminus are lethal, and this portion does not appear to be essential for function so may act as a stabilising region.


The actual alignment was detected with superfamily member pfam12935:

Pssm-ID: 315590 [Multi-domain]  Cd Length: 236  Bit Score: 70.95  E-value: 4.38e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  279 GSRYEEGVPLiphsESNGEVSQPEQKLAG-------F-GDEVAGEDDFFSQIQNsnNDDFPDFSGNHPLERKSTMQVMGD 350
Cdd:pfam12935   35 ESRFEEGVPL----LDNGDDTPVENRSKQesqidsvFaGDEEDDEADFFSSNQE--SESKKEGEPNDHLTRKSTSQVLDS 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  351 MNTN-------TLSRADTLGEMLE--EDEDVDEPTKSTEEPAEPIQSEDSSAKPA-----DDLAAKWeQAFADDDgEDFL 416
Cdd:pfam12935  109 LKDPpdspesdDSPAAEDFDEILAaaATEKQQEKSPSEEDLAARWQAELSDEVPEpmpmeDDLAERW-QAFLDDD-DDLL 186

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1868502967  417 LDeslDEAGESKPVDPSAFFGSDDEGFLDDDDDDLPTAAAPApvvQPAGQQNRYTP 472
Cdd:pfam12935  187 LD---DETLDANSAPEEEPNGPTNDSTANSLSSPFGTPQSRY---RPKPPPNPYTP 236
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 458-960 1.07e-11

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 70.74  E-value: 1.07e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  458 APVVQ-PAGQQNRYTPTVASHQASSSPYAPTAPAVPSPYQP-----QNAATSFAPAVAPYTAQRTQSAAPYNAQQTRPEP 531
Cdd:PHA03247  2477 APVYRrPAEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPailpdEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPLP 2556

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  532 VKAQSFAAQSKGGYTSPYDLPMEVVVPKKRASTNQLPQSPSTGPSSGPPPRSSSMQAPTPPPPPRAATSSASPPTSSHSG 611
Cdd:PHA03247  2557 PAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAAN 2636

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  612 QPPPAGKPVPVLRNKDSFFEELPMASKPRSASRQSYRVGSPA-LAGPPEPLQPQNQAQLAPSPLSPPMLSPPGMNrslsg 690
Cdd:PHA03247  2637 EPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSpPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA----- 2711

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  691 giPHLVPGERVNPYAPQTTQQQVPGIPGnarySPAPPSAPNTNGTNRPPSASRYSPAPTASRPPVPAFHAATTPPTVLPH 770
Cdd:PHA03247  2712 --PHALVSATPLPPGPAAARQASPALPA----APAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR 2785

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  771 LPrtssplahfeVSREAAATNGDHSQPDRRSSYSLEPRRVPSLPTTreveeeddsktsyaAQPANGVPaesryspaPPTV 850
Cdd:PHA03247  2786 PA----------VASLSESRESLPSPWDPADPPAAVLAPAAALPPA--------------ASPAGPLP--------PPTS 2833

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  851 ARQTPPPSSHGP-----PLHSTLSP----SKRSTSNYLP-QAALHDSPPDNRYAPPPRSQTQSPgssqGAHPPSQPvPRP 920
Cdd:PHA03247  2834 AQPTAPPPPPGPpppslPLGGSVAPggdvRRRPPSRSPAaKPAAPARPPVRRLARPAVSRSTES----FALPPDQP-ERP 2908

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 1868502967  921 TSVHSPTSPRATRSFQPINAPVSRPRGPSQTFNWVAPTDG 960
Cdd:PHA03247  2909 PQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948
PTZ00395 super family cl33180
Sec24-related protein; Provisional
 1516-1711 5.23e-04

Sec24-related protein; Provisional


The actual alignment was detected with superfamily member PTZ00395:

Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 45.45  E-value: 5.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1516 PATRAAsrYAPGPSQtplSSSYEPGAGYTPGPASVGRSSNEYSRSPYeprtsmdSQPGYSNGGYM-PQNATAPsqgYTPP 1594
Cdd:PTZ00395   373 PDARGA--WAGGPHS---NASYNCAAYSNAAQSNAAQSNAGFSNAGY-------SNPGNSNPGYNnAPNSNTP---YNNP 437

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1595 MYgggqdttasaqvlsgavQNSPMQSPTkpeyqgyepygsqdppvpsvevqsqeaagNSQQPNNNL--ANSGYQPPSYGY 1672
Cdd:PTZ00395   438 PN-----------------SNTPYSNPP-----------------------------NSNPPYSNLpySNTPYSNAPLSN 471

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1868502967 1673 EPPSMSNDEPQSQSAEPTEGGGYEPPTFQPYGYEPPSYN 1711
Cdd:PTZ00395   472 APPSSAKDHHSAYHAAYQHRAANQPAANLPTANQPAANN 510
YobN super family cl34196
Monoamine oxidase [Amino acid transport and metabolism];
1059-1145 1.84e-03

Monoamine oxidase [Amino acid transport and metabolism];


The actual alignment was detected with superfamily member COG1231:

Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 42.99  E-value: 1.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1059 VSFQPQLSHEHKRAIERLLLW---KIL----RVFVEHDGVLEGTTAVDKAVRDVLAPGVDADANEGTL-GYGAGLGADAL 1130
Cdd:COG1231    259 IEFDPPLPAAKRAAIQRLPYGaaiKVFlqfdRPFWEEDGLYGGISLTDLPIRQTWYPSNGPDGGAGVLlGYVGGDDARAL 338

                           90
                   ....*....|....*
gi 1868502967 1131 QESSSTQMKAEVVDS 1145
Cdd:COG1231    339 AALSPEERVAAALEQ 353
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 14-195 2.47e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 2.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967   14 MPNDASGHATTETQVSSSAETHDSPSAPplhSQLAEDVEPTTLPQATQLESKPEEQSTPWLAEDDSQdasddwpvferPV 93
Cdd:pfam05109  454 VPTNLTAPASTGPTVSTADVTSPTPAGT---TSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPT-----------PN 519

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967   94 SDAPAESDDSPKEASTSTTAAEPEPNSFTSTEPANDIAPQPQPVADEAKPSAPTLGHTSTNSFTRTVSHEV-------NW 166
Cdd:pfam05109  520 ATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNAtsptvgeTS 599

                          170       180
                   ....*....|....*....|....*....
gi 1868502967  167 DDDHDTEWTLPRTDTDPFKFMPPNERTNS 195
Cdd:pfam05109  600 PQANTTNHTLGGTSSTPVVTSPPKNATSA 628
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1487-1906 6.52e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 6.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1487 SPSVTNFEPMyGTGATSLPVGSPPAAVPIPATRAASRYAPGPSQTPLSSSYEPGAGYTPGPASVGrSSNEYSRSPYEPRT 1566
Cdd:PHA03247  2630 SPSPAANEPD-PHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVG-SLTSLADPPPPPPT 2707

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1567 SMDSQPGYSNGGYMPQNATAPSQGYTPPMYGGGQDTTASAQVLSGAVQNSPMQSPTKPEYQGYEPYGSQDPPVPSVEVqs 1646
Cdd:PHA03247  2708 PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR-- 2785

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1647 qeAAGNSQQPNNNLANSGYQPPSYGYEPPSMSNDEPQSQSAEPTEGggyEPPTFQPYGYEPPSYNPEPEQDDEG------ 1720
Cdd:PHA03247  2786 --PAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLP---PPTSAQPTAPPPPPGPPPPSLPLGGsvapgg 2860

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1721 --ESRPKPKSfmddddDDDIPALKALKPQEKGKSEKDKENEEMFKKAAEEDAKRAAAQQQSKKGWGFGSWFGGKKEASPD 1798
Cdd:PHA03247  2861 dvRRRPPSRS------PAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP 2934

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1799 PQQQGNKPVK-----ANLGESSSFVYDPDLKRWVnkKGGAEATQAKTATPPPPKGAPRSntgtpppprtmtppmgrASAP 1873
Cdd:PHA03247  2935 PPPRPQPPLApttdpAGAGEPSGAVPQPWLGALV--PGRVAVPRFRVPQPAPSREAPAS-----------------STPP 2995

                          410       420       430
                   ....*....|....*....|....*....|...
gi 1868502967 1874 PGGPPGPALAHAASNESLGVPPGPRPPSMMRSV 1906
Cdd:PHA03247  2996 LTGHSLSRVSSWASSLALHEETDPPPVSLKQTL 3028
 
Name Accession Description Interval E-value
Sec16_C pfam12931
Sec23-binding domain of Sec16; Sec16 is a multi-domain vesicle coat protein. The C-terminal ...
 1151-1454 1.96e-142

Sec23-binding domain of Sec16; Sec16 is a multi-domain vesicle coat protein. The C-terminal region is the part that binds to Sec23, a COPII vesicle coat protein. This association is part of the transport vesicle coat structure.


Pssm-ID: 432884  Cd Length: 279  Bit Score: 442.77  E-value: 1.96e-142
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1151 IRKHLLVGDREKAVWEAADKRLWGHAMLISNTVSPDLYKQVAQEFVRKEVNYPG-HANESIAALYKVLSGNFDDCVDELV 1229
Cdd:pfam12931    1 IRALLLTGDREKALWLALDKKLWAHALLIASTLGKEKWKEVVQEFVRSEFKGSNnKSGESLAALYQVFAGNSEEAVDELV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1230 PAharagfqlvnttsasgsSKDATEGLDKWRETLGLVLSNRSTDDIRALNALGNLLSSYGRAEAAHICFLFARKatvfgg 1309
Cdd:pfam12931   81 PP-----------------SKNALWALDNWRETLALVLSNRSPGDVEALLALGDLLAQYGRTEAAHICFLLAGL------ 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1310 lddPASNFVLVGADHKTQGEQFAKETEALLLSEVYEYGLSLAGGPTLTVGVPHLAAYKLQHAMTLAEYGLRDKALQYCEA 1389
Cdd:pfam12931  138 ---PLSQTVLLGADHVRFPSTFGNDLESILLTEIYEYALSLSPPQPPFVGLPHLLPYKLQHAAVLAEYGLVSEAQKYCDA 214

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1868502967 1390 IASSINAQTKRSNYHHPILETAVENLRTRLRQAPKEESSSWISKPSMNKVSDTVWSRFNKFVAGD 1454
Cdd:pfam12931  215 ITASLKSLTKKSPYYHPTLLAQLEDLSNRLSQSPQGKSSSWISKPSLDKVWGQLDKSFNKFIAGD 279
ACE1-Sec16-like cd09233
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat ...
 1028-1423 7.10e-92

Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat complex plays an important role in vesicular traffic of newly synthezised proteins from the endoplasmatic reticulum (ER) to the Golgi apparatus by mediating the formation of transport vesicles. COPII consists of an outer coat, made up of the scaffold proteins Sec31 and Sec13, and the cargo adaptor complex, Sec23 and Sec24, which are recruited by the small GTPase Sar1. Sec16 is involved in the early steps of the assembly process. Sec16 forms elongated heterotetramers with Sec13, Sec13-(Sec16)2-Sec13. It interacts with Sec13 by insertion of a single beta-blade to close the six-bladded beta propeller of Sec13. In the same way Sec13 interacts with Sec31 and Nup145C, a nuclear pore protein, all of these contain a structurally related ancestral coatomer element 1 (ACE1). Sec16 is believed to be a key component in maintaining the integrity of the ER exit site.


Pssm-ID: 187750 [Multi-domain]  Cd Length: 314  Bit Score: 301.10  E-value: 7.10e-92
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1028 FPGPL-RGKSKKKETIAWLSSGIDTLEKELPEVsfqpqlshehkRAIERLLLWKILRVFVEHDGVLEGTtavdkavrdvl 1106
Cdd:cd09233      1 FPGPLiKGKTKKKDVLKWLEEKIAELEENEGYL-----------DLEDKLLLWKLLKLLVRQNGKLVGT----------- 58

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1107 apgvdadanegtlgygaglgadalqessstqmkaEVVDSSTMDQIRKHLLVGDREKAVWEAADKRLWGHAMLISNTVSPD 1186
Cdd:cd09233     59 ----------------------------------DIAEQKALNRFRNLLLTGNRKEALELALDNGLWAHALLLASSLGKE 104

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1187 LYKQVAQEFVRKEvnypGHANESIAALYKVLSGNFDDCVDELVPAHARAGFQlvnttsasgsskdategLDKWRETLGLV 1266
Cdd:cd09233    105 TWAEVVSRFARSE----SKLNDPLQTLYQLFSGNSPEAITELADNPAEAEWA-----------------LGNWREHLAII 163

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1267 LSNRSTD-DIRALNALGNLLSSYGRAEAAHICFLFARKAtvFGGLDDPASNFVLVGADHKTQGEQFAkETEALLLSEVYE 1345
Cdd:cd09233    164 LSNRTSNlDLEALVELGDLLAQRGLVEAAHICYLLAGVP--LGPYPSSPSSCLLGGAVHNKSPRTFA-TPEAIQLTEIYE 240

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1868502967 1346 YGLSLAggpTLTVGVPHLAAYKLQHAMTLAEYGLRDKALQYCEAIASSINAQTKRSNYhHPILETAVENLRTRLRQAP 1423
Cdd:cd09233    241 YALSLG---NPQFGLPHLQPYKLIHAARLAELGLVSEALKYCEAIASSLKSLTKSPYY-DPNLLAQLQDLSERLSGTS 314
Sec16 pfam12932
Vesicle coat trafficking protein Sec16 mid-region; Sec16 is a multi-domain vesicle coat ...
 972-1090 1.86e-57

Vesicle coat trafficking protein Sec16 mid-region; Sec16 is a multi-domain vesicle coat protein. This central region is the functional part of the molecules and thus is vital for the family's role in mediating the movement of protein-cargo between the organelles of the secretory pathway.


Pssm-ID: 432885  Cd Length: 119  Bit Score: 194.36  E-value: 1.86e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  972 APIISWGVGGTMVTSFPKNVPRYGMGQTAPMIIRSPGEVHVKHIKDTQPLEERLAKFPGPL-RGKSKKKETIAWLSSGID 1050
Cdd:pfam12932    1 HPIFSFGFGGKLVTMFPKRVPRYSTGQDVPMIKRSPGEVKIRNLKDVVPLSEDLAKFPGPLvKGKSKKKEVLKWLSERIE 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1868502967 1051 TLEKELPEvSFQPQLSHEHKRAIERLLLWKILRVFVEHDG 1090
Cdd:pfam12932   81 ELEQSLPY-SDGSLESDEKKRAEEKLLLWKLLKILVEHDG 119
Sec16_N pfam12935
Vesicle coat trafficking protein Sec16 N-terminus; Sec16 is a multi-domain vesicle coat ...
 279-472 4.38e-13

Vesicle coat trafficking protein Sec16 N-terminus; Sec16 is a multi-domain vesicle coat protein. The overall function of Sec16 is in mediating the movement of protein-cargo between the organelles of the secretory pathway. Over-expression of truncated mutants of only the N-terminus are lethal, and this portion does not appear to be essential for function so may act as a stabilising region.


Pssm-ID: 315590 [Multi-domain]  Cd Length: 236  Bit Score: 70.95  E-value: 4.38e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  279 GSRYEEGVPLiphsESNGEVSQPEQKLAG-------F-GDEVAGEDDFFSQIQNsnNDDFPDFSGNHPLERKSTMQVMGD 350
Cdd:pfam12935   35 ESRFEEGVPL----LDNGDDTPVENRSKQesqidsvFaGDEEDDEADFFSSNQE--SESKKEGEPNDHLTRKSTSQVLDS 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  351 MNTN-------TLSRADTLGEMLE--EDEDVDEPTKSTEEPAEPIQSEDSSAKPA-----DDLAAKWeQAFADDDgEDFL 416
Cdd:pfam12935  109 LKDPpdspesdDSPAAEDFDEILAaaATEKQQEKSPSEEDLAARWQAELSDEVPEpmpmeDDLAERW-QAFLDDD-DDLL 186

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1868502967  417 LDeslDEAGESKPVDPSAFFGSDDEGFLDDDDDDLPTAAAPApvvQPAGQQNRYTP 472
Cdd:pfam12935  187 LD---DETLDANSAPEEEPNGPTNDSTANSLSSPFGTPQSRY---RPKPPPNPYTP 236
PHA03247 PHA03247
large tegument protein UL36; Provisional
 458-960 1.07e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 70.74  E-value: 1.07e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  458 APVVQ-PAGQQNRYTPTVASHQASSSPYAPTAPAVPSPYQP-----QNAATSFAPAVAPYTAQRTQSAAPYNAQQTRPEP 531
Cdd:PHA03247  2477 APVYRrPAEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPailpdEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPLP 2556

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  532 VKAQSFAAQSKGGYTSPYDLPMEVVVPKKRASTNQLPQSPSTGPSSGPPPRSSSMQAPTPPPPPRAATSSASPPTSSHSG 611
Cdd:PHA03247  2557 PAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAAN 2636

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  612 QPPPAGKPVPVLRNKDSFFEELPMASKPRSASRQSYRVGSPA-LAGPPEPLQPQNQAQLAPSPLSPPMLSPPGMNrslsg 690
Cdd:PHA03247  2637 EPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSpPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA----- 2711

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  691 giPHLVPGERVNPYAPQTTQQQVPGIPGnarySPAPPSAPNTNGTNRPPSASRYSPAPTASRPPVPAFHAATTPPTVLPH 770
Cdd:PHA03247  2712 --PHALVSATPLPPGPAAARQASPALPA----APAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR 2785

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  771 LPrtssplahfeVSREAAATNGDHSQPDRRSSYSLEPRRVPSLPTTreveeeddsktsyaAQPANGVPaesryspaPPTV 850
Cdd:PHA03247  2786 PA----------VASLSESRESLPSPWDPADPPAAVLAPAAALPPA--------------ASPAGPLP--------PPTS 2833

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  851 ARQTPPPSSHGP-----PLHSTLSP----SKRSTSNYLP-QAALHDSPPDNRYAPPPRSQTQSPgssqGAHPPSQPvPRP 920
Cdd:PHA03247  2834 AQPTAPPPPPGPpppslPLGGSVAPggdvRRRPPSRSPAaKPAAPARPPVRRLARPAVSRSTES----FALPPDQP-ERP 2908

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 1868502967  921 TSVHSPTSPRATRSFQPINAPVSRPRGPSQTFNWVAPTDG 960
Cdd:PHA03247  2909 PQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 610-950 3.25e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.91  E-value: 3.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  610 SGQPPPAGKPVPVLRNKD----SFFEELPMASKPRSASRQSYRVGSPALAGPPE-PLQPQNQAQLAPSPLSPPMLSPPGM 684
Cdd:pfam03154  207 PPQGSPATSQPPNQTQSTaaphTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQvSPQPLPQPSLHGQMPPMPHSLQTGP 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  685 NRslsggIPHLVPGERVnPYAPQTTQQQVPGIPGNARYSPAP--PSAPNTNGTNRPPSASRYSPAPTAsrpPVPAFHAAT 762
Cdd:pfam03154  287 SH-----MQHPVPPQPF-PLTPQSSQSQVPPGPSPAAPGQSQqrIHTPPSQSQLQSQQPPREQPLPPA---PLSMPHIKP 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  763 TPPTVLPHLPRTSSplahfevsreaaatngdHSQPDRRSSYSlePRRVPS-LPTTReveeeddsktsyAAQPANGVPAES 841
Cdd:pfam03154  358 PPTTPIPQLPNPQS-----------------HKHPPHLSGPS--PFQMNSnLPPPP------------ALKPLSSLSTHH 406

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  842 RYSPAPPTV-----ARQTPPPSSHGPPLHSTLSPSKrSTSNYLPQAALHDSPPDNRYAPPPRSQTQSPGSSQGAHPPSQP 916
Cdd:pfam03154  407 PPSAHPPPLqlmpqSQQLPPPPAQPPVLTQSQSLPP-PAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTST 485

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1868502967  917 VPRPTSVHSPTSPRATRSfQPINAPVSRPRGPSQ 950
Cdd:pfam03154  486 SSAMPGIQPPSSASVSSS-GPVPAAVSCPLPPVQ 518
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 1516-1711 5.23e-04

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 45.45  E-value: 5.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1516 PATRAAsrYAPGPSQtplSSSYEPGAGYTPGPASVGRSSNEYSRSPYeprtsmdSQPGYSNGGYM-PQNATAPsqgYTPP 1594
Cdd:PTZ00395   373 PDARGA--WAGGPHS---NASYNCAAYSNAAQSNAAQSNAGFSNAGY-------SNPGNSNPGYNnAPNSNTP---YNNP 437

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1595 MYgggqdttasaqvlsgavQNSPMQSPTkpeyqgyepygsqdppvpsvevqsqeaagNSQQPNNNL--ANSGYQPPSYGY 1672
Cdd:PTZ00395   438 PN-----------------SNTPYSNPP-----------------------------NSNPPYSNLpySNTPYSNAPLSN 471

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1868502967 1673 EPPSMSNDEPQSQSAEPTEGGGYEPPTFQPYGYEPPSYN 1711
Cdd:PTZ00395   472 APPSSAKDHHSAYHAAYQHRAANQPAANLPTANQPAANN 510
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
1059-1145 1.84e-03

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 42.99  E-value: 1.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1059 VSFQPQLSHEHKRAIERLLLW---KIL----RVFVEHDGVLEGTTAVDKAVRDVLAPGVDADANEGTL-GYGAGLGADAL 1130
Cdd:COG1231    259 IEFDPPLPAAKRAAIQRLPYGaaiKVFlqfdRPFWEEDGLYGGISLTDLPIRQTWYPSNGPDGGAGVLlGYVGGDDARAL 338

                           90
                   ....*....|....*
gi 1868502967 1131 QESSSTQMKAEVVDS 1145
Cdd:COG1231    339 AALSPEERVAAALEQ 353
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 14-195 2.47e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 2.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967   14 MPNDASGHATTETQVSSSAETHDSPSAPplhSQLAEDVEPTTLPQATQLESKPEEQSTPWLAEDDSQdasddwpvferPV 93
Cdd:pfam05109  454 VPTNLTAPASTGPTVSTADVTSPTPAGT---TSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPT-----------PN 519

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967   94 SDAPAESDDSPKEASTSTTAAEPEPNSFTSTEPANDIAPQPQPVADEAKPSAPTLGHTSTNSFTRTVSHEV-------NW 166
Cdd:pfam05109  520 ATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNAtsptvgeTS 599

                          170       180
                   ....*....|....*....|....*....
gi 1868502967  167 DDDHDTEWTLPRTDTDPFKFMPPNERTNS 195
Cdd:pfam05109  600 PQANTTNHTLGGTSSTPVVTSPPKNATSA 628
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1487-1906 6.52e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 6.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1487 SPSVTNFEPMyGTGATSLPVGSPPAAVPIPATRAASRYAPGPSQTPLSSSYEPGAGYTPGPASVGrSSNEYSRSPYEPRT 1566
Cdd:PHA03247  2630 SPSPAANEPD-PHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVG-SLTSLADPPPPPPT 2707

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1567 SMDSQPGYSNGGYMPQNATAPSQGYTPPMYGGGQDTTASAQVLSGAVQNSPMQSPTKPEYQGYEPYGSQDPPVPSVEVqs 1646
Cdd:PHA03247  2708 PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR-- 2785

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1647 qeAAGNSQQPNNNLANSGYQPPSYGYEPPSMSNDEPQSQSAEPTEGggyEPPTFQPYGYEPPSYNPEPEQDDEG------ 1720
Cdd:PHA03247  2786 --PAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLP---PPTSAQPTAPPPPPGPPPPSLPLGGsvapgg 2860

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1721 --ESRPKPKSfmddddDDDIPALKALKPQEKGKSEKDKENEEMFKKAAEEDAKRAAAQQQSKKGWGFGSWFGGKKEASPD 1798
Cdd:PHA03247  2861 dvRRRPPSRS------PAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP 2934

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1799 PQQQGNKPVK-----ANLGESSSFVYDPDLKRWVnkKGGAEATQAKTATPPPPKGAPRSntgtpppprtmtppmgrASAP 1873
Cdd:PHA03247  2935 PPPRPQPPLApttdpAGAGEPSGAVPQPWLGALV--PGRVAVPRFRVPQPAPSREAPAS-----------------STPP 2995

                          410       420       430
                   ....*....|....*....|....*....|...
gi 1868502967 1874 PGGPPGPALAHAASNESLGVPPGPRPPSMMRSV 1906
Cdd:PHA03247  2996 LTGHSLSRVSSWASSLALHEETDPPPVSLKQTL 3028
 
Name Accession Description Interval E-value
Sec16_C pfam12931
Sec23-binding domain of Sec16; Sec16 is a multi-domain vesicle coat protein. The C-terminal ...
 1151-1454 1.96e-142

Sec23-binding domain of Sec16; Sec16 is a multi-domain vesicle coat protein. The C-terminal region is the part that binds to Sec23, a COPII vesicle coat protein. This association is part of the transport vesicle coat structure.


Pssm-ID: 432884  Cd Length: 279  Bit Score: 442.77  E-value: 1.96e-142
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1151 IRKHLLVGDREKAVWEAADKRLWGHAMLISNTVSPDLYKQVAQEFVRKEVNYPG-HANESIAALYKVLSGNFDDCVDELV 1229
Cdd:pfam12931    1 IRALLLTGDREKALWLALDKKLWAHALLIASTLGKEKWKEVVQEFVRSEFKGSNnKSGESLAALYQVFAGNSEEAVDELV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1230 PAharagfqlvnttsasgsSKDATEGLDKWRETLGLVLSNRSTDDIRALNALGNLLSSYGRAEAAHICFLFARKatvfgg 1309
Cdd:pfam12931   81 PP-----------------SKNALWALDNWRETLALVLSNRSPGDVEALLALGDLLAQYGRTEAAHICFLLAGL------ 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1310 lddPASNFVLVGADHKTQGEQFAKETEALLLSEVYEYGLSLAGGPTLTVGVPHLAAYKLQHAMTLAEYGLRDKALQYCEA 1389
Cdd:pfam12931  138 ---PLSQTVLLGADHVRFPSTFGNDLESILLTEIYEYALSLSPPQPPFVGLPHLLPYKLQHAAVLAEYGLVSEAQKYCDA 214

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1868502967 1390 IASSINAQTKRSNYHHPILETAVENLRTRLRQAPKEESSSWISKPSMNKVSDTVWSRFNKFVAGD 1454
Cdd:pfam12931  215 ITASLKSLTKKSPYYHPTLLAQLEDLSNRLSQSPQGKSSSWISKPSLDKVWGQLDKSFNKFIAGD 279
ACE1-Sec16-like cd09233
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat ...
 1028-1423 7.10e-92

Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat complex plays an important role in vesicular traffic of newly synthezised proteins from the endoplasmatic reticulum (ER) to the Golgi apparatus by mediating the formation of transport vesicles. COPII consists of an outer coat, made up of the scaffold proteins Sec31 and Sec13, and the cargo adaptor complex, Sec23 and Sec24, which are recruited by the small GTPase Sar1. Sec16 is involved in the early steps of the assembly process. Sec16 forms elongated heterotetramers with Sec13, Sec13-(Sec16)2-Sec13. It interacts with Sec13 by insertion of a single beta-blade to close the six-bladded beta propeller of Sec13. In the same way Sec13 interacts with Sec31 and Nup145C, a nuclear pore protein, all of these contain a structurally related ancestral coatomer element 1 (ACE1). Sec16 is believed to be a key component in maintaining the integrity of the ER exit site.


Pssm-ID: 187750 [Multi-domain]  Cd Length: 314  Bit Score: 301.10  E-value: 7.10e-92
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1028 FPGPL-RGKSKKKETIAWLSSGIDTLEKELPEVsfqpqlshehkRAIERLLLWKILRVFVEHDGVLEGTtavdkavrdvl 1106
Cdd:cd09233      1 FPGPLiKGKTKKKDVLKWLEEKIAELEENEGYL-----------DLEDKLLLWKLLKLLVRQNGKLVGT----------- 58

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1107 apgvdadanegtlgygaglgadalqessstqmkaEVVDSSTMDQIRKHLLVGDREKAVWEAADKRLWGHAMLISNTVSPD 1186
Cdd:cd09233     59 ----------------------------------DIAEQKALNRFRNLLLTGNRKEALELALDNGLWAHALLLASSLGKE 104

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1187 LYKQVAQEFVRKEvnypGHANESIAALYKVLSGNFDDCVDELVPAHARAGFQlvnttsasgsskdategLDKWRETLGLV 1266
Cdd:cd09233    105 TWAEVVSRFARSE----SKLNDPLQTLYQLFSGNSPEAITELADNPAEAEWA-----------------LGNWREHLAII 163

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1267 LSNRSTD-DIRALNALGNLLSSYGRAEAAHICFLFARKAtvFGGLDDPASNFVLVGADHKTQGEQFAkETEALLLSEVYE 1345
Cdd:cd09233    164 LSNRTSNlDLEALVELGDLLAQRGLVEAAHICYLLAGVP--LGPYPSSPSSCLLGGAVHNKSPRTFA-TPEAIQLTEIYE 240

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1868502967 1346 YGLSLAggpTLTVGVPHLAAYKLQHAMTLAEYGLRDKALQYCEAIASSINAQTKRSNYhHPILETAVENLRTRLRQAP 1423
Cdd:cd09233    241 YALSLG---NPQFGLPHLQPYKLIHAARLAELGLVSEALKYCEAIASSLKSLTKSPYY-DPNLLAQLQDLSERLSGTS 314
Sec16 pfam12932
Vesicle coat trafficking protein Sec16 mid-region; Sec16 is a multi-domain vesicle coat ...
 972-1090 1.86e-57

Vesicle coat trafficking protein Sec16 mid-region; Sec16 is a multi-domain vesicle coat protein. This central region is the functional part of the molecules and thus is vital for the family's role in mediating the movement of protein-cargo between the organelles of the secretory pathway.


Pssm-ID: 432885  Cd Length: 119  Bit Score: 194.36  E-value: 1.86e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  972 APIISWGVGGTMVTSFPKNVPRYGMGQTAPMIIRSPGEVHVKHIKDTQPLEERLAKFPGPL-RGKSKKKETIAWLSSGID 1050
Cdd:pfam12932    1 HPIFSFGFGGKLVTMFPKRVPRYSTGQDVPMIKRSPGEVKIRNLKDVVPLSEDLAKFPGPLvKGKSKKKEVLKWLSERIE 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1868502967 1051 TLEKELPEvSFQPQLSHEHKRAIERLLLWKILRVFVEHDG 1090
Cdd:pfam12932   81 ELEQSLPY-SDGSLESDEKKRAEEKLLLWKLLKILVEHDG 119
Sec16_N pfam12935
Vesicle coat trafficking protein Sec16 N-terminus; Sec16 is a multi-domain vesicle coat ...
 279-472 4.38e-13

Vesicle coat trafficking protein Sec16 N-terminus; Sec16 is a multi-domain vesicle coat protein. The overall function of Sec16 is in mediating the movement of protein-cargo between the organelles of the secretory pathway. Over-expression of truncated mutants of only the N-terminus are lethal, and this portion does not appear to be essential for function so may act as a stabilising region.


Pssm-ID: 315590 [Multi-domain]  Cd Length: 236  Bit Score: 70.95  E-value: 4.38e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  279 GSRYEEGVPLiphsESNGEVSQPEQKLAG-------F-GDEVAGEDDFFSQIQNsnNDDFPDFSGNHPLERKSTMQVMGD 350
Cdd:pfam12935   35 ESRFEEGVPL----LDNGDDTPVENRSKQesqidsvFaGDEEDDEADFFSSNQE--SESKKEGEPNDHLTRKSTSQVLDS 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  351 MNTN-------TLSRADTLGEMLE--EDEDVDEPTKSTEEPAEPIQSEDSSAKPA-----DDLAAKWeQAFADDDgEDFL 416
Cdd:pfam12935  109 LKDPpdspesdDSPAAEDFDEILAaaATEKQQEKSPSEEDLAARWQAELSDEVPEpmpmeDDLAERW-QAFLDDD-DDLL 186

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1868502967  417 LDeslDEAGESKPVDPSAFFGSDDEGFLDDDDDDLPTAAAPApvvQPAGQQNRYTP 472
Cdd:pfam12935  187 LD---DETLDANSAPEEEPNGPTNDSTANSLSSPFGTPQSRY---RPKPPPNPYTP 236
PHA03247 PHA03247
large tegument protein UL36; Provisional
 458-960 1.07e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 70.74  E-value: 1.07e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  458 APVVQ-PAGQQNRYTPTVASHQASSSPYAPTAPAVPSPYQP-----QNAATSFAPAVAPYTAQRTQSAAPYNAQQTRPEP 531
Cdd:PHA03247  2477 APVYRrPAEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPailpdEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPLP 2556

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  532 VKAQSFAAQSKGGYTSPYDLPMEVVVPKKRASTNQLPQSPSTGPSSGPPPRSSSMQAPTPPPPPRAATSSASPPTSSHSG 611
Cdd:PHA03247  2557 PAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAAN 2636

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  612 QPPPAGKPVPVLRNKDSFFEELPMASKPRSASRQSYRVGSPA-LAGPPEPLQPQNQAQLAPSPLSPPMLSPPGMNrslsg 690
Cdd:PHA03247  2637 EPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSpPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA----- 2711

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  691 giPHLVPGERVNPYAPQTTQQQVPGIPGnarySPAPPSAPNTNGTNRPPSASRYSPAPTASRPPVPAFHAATTPPTVLPH 770
Cdd:PHA03247  2712 --PHALVSATPLPPGPAAARQASPALPA----APAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR 2785

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  771 LPrtssplahfeVSREAAATNGDHSQPDRRSSYSLEPRRVPSLPTTreveeeddsktsyaAQPANGVPaesryspaPPTV 850
Cdd:PHA03247  2786 PA----------VASLSESRESLPSPWDPADPPAAVLAPAAALPPA--------------ASPAGPLP--------PPTS 2833

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  851 ARQTPPPSSHGP-----PLHSTLSP----SKRSTSNYLP-QAALHDSPPDNRYAPPPRSQTQSPgssqGAHPPSQPvPRP 920
Cdd:PHA03247  2834 AQPTAPPPPPGPpppslPLGGSVAPggdvRRRPPSRSPAaKPAAPARPPVRRLARPAVSRSTES----FALPPDQP-ERP 2908

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 1868502967  921 TSVHSPTSPRATRSFQPINAPVSRPRGPSQTFNWVAPTDG 960
Cdd:PHA03247  2909 PQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 610-951 1.12e-09

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 64.04  E-value: 1.12e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  610 SGQPPPAGKPVPVLRNKDSFFEELPMaSKPRSASRQSYRVGSPALAGPPEPLQPQNQAQLAPSPLSPPMLSPPGMNRSLS 689
Cdd:PHA03307    67 PPTGPPPGPGTEAPANESRSTPTWSL-STLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPG 145

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  690 GGIPHLVPGERVNPYAPQTTQQQVPGIPGNARYSPAPPSAPNTNGTNRPPSASRYSPAPTASRPPVPAFHAATTPptvlp 769
Cdd:PHA03307   146 PPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSP----- 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  770 hlprTSSPLAHFEVSREAAATNGDHSQPDRRSSYSLEPRRVPS-----LPTTREVEEEDDSKTSYAAQPANGVPAESRYS 844
Cdd:PHA03307   221 ----APAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRpapitLPTRIWEASGWNGPSSRPGPASSSSSPRERSP 296

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  845 PAPPTVARQ-----TPPPSSHGPPLHSTLSPSKRSTSNYLPQAALHDSPPDNRYAPPPRSQTQSPGSSQGAHPPSQPVPR 919
Cdd:PHA03307   297 SPSPSSPGSgpapsSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPS 376

                          330       340       350
                   ....*....|....*....|....*....|..
gi 1868502967  920 PTSVHSPTSPRATRSFQPINAPVSRPRGPSQT 951
Cdd:PHA03307   377 SPAASAGRPTRRRARAAVAGRARRRDATGRFP 408
PHA03247 PHA03247
large tegument protein UL36; Provisional
 429-934 2.26e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.95  E-value: 2.26e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  429 PVDPSAFFGSDDEGFLDDDDDdLPTAAAPAPVVQPAGQQ----NRYTPTVASHQASSSPYAPTAPAVPSPYQPqnaATSF 504
Cdd:PHA03247  2623 APDPPPPSPSPAANEPDPHPP-PTVPPPERPRDDPAPGRvsrpRRARRLGRAAQASSPPQRPRRRAARPTVGS---LTSL 2698

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  505 APAVAPytaQRTQSAAPYNAQQTRPEPVKAQSFAAQSKGGYTSPydlpmevvVPKKRASTNQLPQSPSTGPSSGPPP--R 582
Cdd:PHA03247  2699 ADPPPP---PPTPEPAPHALVSATPLPPGPAAARQASPALPAAP--------APPAVPAGPATPGGPARPARPPTTAgpP 2767

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  583 SSSMQAPTPPPPPRAATSSASPPTSSHSGQPPPAGKPVPVLRNKDSFFEELPMASKPRSASRQSYRVGSPALAGPPEPLQ 662
Cdd:PHA03247  2768 APAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPP 2847

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  663 PqnqaqlaPSPLSPPMLSPPGMNRSLSGGIPHLVPGERVNPYAPQTTQQQVPGIPGNARYSPAPPSAPNTNGTNRPPSAS 742
Cdd:PHA03247  2848 P-------SLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQ 2920

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  743 RYSPAPTASRPPVPAFHAATTPPTVLPHLPRTSSPLAHFEVSREAAATNGDHSQPDRRSSYSLEPRRVPSLPTTREVEEE 822
Cdd:PHA03247  2921 PQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHS 3000

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  823 DDSKTSYAAQPANGVPAEsryspAPPTVARQTPPPSSHGPplHSTLSPSKRSTSNYLPQAALHDSPPDNRYAPPPRSQTQ 902
Cdd:PHA03247  3001 LSRVSSWASSLALHEETD-----PPPVSLKQTLWPPDDTE--DSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPA 3073

                          490       500       510
                   ....*....|....*....|....*....|..
gi 1868502967  903 SPGSSQGAHPPSQPVPRPTSVHSPTSPRATRS 934
Cdd:PHA03247  3074 TPEAGARESPSSQFGPPPLSANAALSRRYVRS 3105
PHA03247 PHA03247
large tegument protein UL36; Provisional
 452-966 4.18e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.80  E-value: 4.18e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  452 PTAAAPAPVvQPAGQQNRYTPTVASHQAS-----SSPYAPTAPAVPSPYQPQNAATSfAPAVAPYTAQRTQSAAPYNAQQ 526
Cdd:PHA03247  2570 PPRPAPRPS-EPAVTSRARRPDAPPQSARprapvDDRGDPRGPAPPSPLPPDTHAPD-PPPPSPSPAANEPDPHPPPTVP 2647

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  527 TRPEPVKAQSFAAQSKGGYTSPYDLPMEVVVPKKRASTNQLPQSPSTGPSSGPPPRSSSMQAPTPPPPPRAATSSASPPT 606
Cdd:PHA03247  2648 PPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAA 2727

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  607 SSHSGQPPPAGKPVPvlrnkdsffeelPMASKPRSASRQSYRVGSPALAGPPEPLQPQNQAqlapsplsppmlsppgmnr 686
Cdd:PHA03247  2728 ARQASPALPAAPAPP------------AVPAGPATPGGPARPARPPTTAGPPAPAPPAAPA------------------- 2776

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  687 slsGGIPHLVPGERVNPYAPQTTQQQVPGIPGNARYS-PAPPSAPNTNGTNRPPSASRYSPAPTASRPPvPAFHAATTPP 765
Cdd:PHA03247  2777 ---AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAvLAPAAALPPAASPAGPLPPPTSAQPTAPPPP-PGPPPPSLPL 2852

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  766 --TVLPhlprtSSPLAHFEVSREAAATNGDHSQPdrrssyslEPRRVPSLPTTREVEEEDDSKTSYAAQPANGVPAESRY 843
Cdd:PHA03247  2853 ggSVAP-----GGDVRRRPPSRSPAAKPAAPARP--------PVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQP 2919

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  844 SPAPPTVARQTPPPSSHG---PPLHSTLSPSKRSTSNYLPQAALHDSPPDNRYaPPPRSQTQSPGSSQGAHPPSQPVPRP 920
Cdd:PHA03247  2920 QPQPPPPPQPQPPPPPPPrpqPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRV-AVPRFRVPQPAPSREAPASSTPPLTG 2998

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*.
gi 1868502967  921 TSVHSPTSPRATRSFQPINAPvsRPRGPSQTFNWVAPTDGRENDSL 966
Cdd:PHA03247  2999 HSLSRVSSWASSLALHEETDP--PPVSLKQTLWPPDDTEDSDADSL 3042
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
737-958 1.36e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 53.34  E-value: 1.36e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  737 RPPSASRYSPAPTASRPPVPAFHAATTPPTVLPhlPRTSSPLAHFEVSREAAATNGDHSQPDRRSSYSLEPRRVPSLPTT 816
Cdd:PRK12323   364 RPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAA--PAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASA 441

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  817 REVEEEDDSKTSYAAQPANGVPAESrySPAPPTVARQTPPPSSHGPPLHSTLSPSKRSTSNYLPQAALHDSP--PDNRYA 894
Cdd:PRK12323   442 RGPGGAPAPAPAPAAAPAAAARPAA--AGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPaqPDAAPA 519

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1868502967  895 PPPRSQTQSPGSSQGAHPPSQPVPRPTSVHSPTSPRATRSFQPINAPVSRPRGPSQTFNWVAPT 958
Cdd:PRK12323   520 GWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPA 583
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
690-949 2.58e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 49.46  E-value: 2.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  690 GGIPHLVPGERVNPYAPQTTQQQVPGIPGNARYSPAPPSAPNTNGTnrPPSASRYSPAPTASRPPVPAFHAATTPPTVlp 769
Cdd:PRK07003   370 GGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAA--AAAAATRAEAPPAAPAPPATADRGDDAADG-- 445

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  770 hlPRTSSPLAHFEVSREAAATNGDhSQPDRRSSYSLEPRRVPSLPTTREVEEEDDSKTSYAAQPANgVPAESRYSPAPPT 849
Cdd:PRK07003   446 --DAPVPAKANARASADSRCDERD-AQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVP-DARAPAAASREDA 521

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  850 VARQTPPPSSHGPPLHSTLSPSKRSTS-----NYLPQAALHDSPPDNRYAPPPRSQTQSPGSSQGAHPPSQPVPRPTsvh 924
Cdd:PRK07003   522 PAAAAPPAPEARPPTPAAAAPAARAGGaaaalDVLRNAGMRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQVPT--- 598

                          250       260
                   ....*....|....*....|....*
gi 1868502967  925 sPTSPRATRSFQPINAPVSRPRGPS 949
Cdd:PRK07003   599 -PRARAATGDAPPNGAARAEQAAES 622
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 455-952 9.20e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.77  E-value: 9.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  455 AAPAPVVQPagqqnryTPTVAShqASSSPYAPTAPAVPSPyQPQNAATSFAPAVAPYT--AQRTQSAAPYNAQQTRPEPV 532
Cdd:PRK10263   334 AAPVEPVTQ-------TPPVAS--VDVPPAQPTVAWQPVP-GPQTGEPVIAPAPEGYPqqSQYAQPAVQYNEPLQQPVQP 403

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  533 KAQSFAAQSKGGYTSPYDLPmEVVVPKKRASTNQLPQSPSTGPSSGPPPRSSSMQAPTPPPPPRAATSSASPPTSSHSGQ 612
Cdd:PRK10263   404 QQPYYAPAAEQPAQQPYYAP-APEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQ 482

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  613 ---PPPAGKPVPVL------RNKDSFFEELPMASKPRSASRQSYRVGSPALAGPPEPLQPQNQAQLAPSplsppmlsppg 683
Cdd:PRK10263   483 pveQQPVVEPEPVVeetkpaRPPLYYFEEVEEKRAREREQLAAWYQPIPEPVKEPEPIKSSLKAPSVAA----------- 551

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  684 mnrslsggIPHLVPGERVNPYAPQTtqQQVPGIPGNARYSPAPPSAPNTNGTNRPPSASRYSPA-PTASRPPVPAFHAAT 762
Cdd:PRK10263   552 --------VPPVEAAAAVSPLASGV--KKATLATGAAATVAAPVFSLANSGGPRPQVKEGIGPQlPRPKRIRVPTRRELA 621

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  763 TPPTVLPhlprtsSPLAHFEVSREAaatngDHSQPDRRSSYSLE----------PRRVPSLPTTREVEEEDDSKTSYAAQ 832
Cdd:PRK10263   622 SYGIKLP------SQRAAEEKAREA-----QRNQYDSGDQYNDDeidamqqdelARQFAQTQQQRYGEQYQHDVPVNAED 690

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  833 PANGVPAE----------SRYSPAPPTVARQTPPPSSHGPPLHSTLSPSKrSTSNYLPQAALHDSPPDNRYAPPPRSQTQ 902
Cdd:PRK10263   691 ADAAAEAElarqfaqtqqQRYSGEQPAGANPFSLDDFEFSPMKALLDDGP-HEPLFTPIVEPVQQPQQPVAPQQQYQQPQ 769

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1868502967  903 SPGSSQGAHP-PSQPVPRPTSVHSPTSPRATrsfQPINAPVSRPRGPSQTF 952
Cdd:PRK10263   770 QPVAPQPQYQqPQQPVAPQPQYQQPQQPVAP---QPQYQQPQQPVAPQPQY 817
dnaA PRK14086
chromosomal replication initiator protein DnaA;
748-953 2.24e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 46.36  E-value: 2.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  748 PTASRPPvpafhaattPPTvlPHLPRTSSPLAHfEVSREAAATNGDHSQPDRRSSYSleprRVPSLPTTREVEEEDDSKT 827
Cdd:PRK14086    90 PSAGEPA---------PPP--PHARRTSEPELP-RPGRRPYEGYGGPRADDRPPGLP----RQDQLPTARPAYPAYQQRP 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  828 SYAAQPANGVPAESRYSPAPPTVARQTPPPSSHGPPLHSTLSPSKRSTSNYlPQAALHDSPPDNRYAPPPRSQTQSPGSS 907
Cdd:PRK14086   154 EPGAWPRAADDYGWQQQRLGFPPRAPYASPASYAPEQERDREPYDAGRPEY-DQRRRDYDHPRPDWDRPRRDRTDRPEPP 232

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1868502967  908 QGAHPPSQ----PVPRPTSVHSPTSPRATRSFQPINAPVSRPRGPSQTFN 953
Cdd:PRK14086   233 PGAGHVHRggpgPPERDDAPVVPIRPSAPGPLAAQPAPAPGPGEPTARLN 282
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 610-950 3.25e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.91  E-value: 3.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  610 SGQPPPAGKPVPVLRNKD----SFFEELPMASKPRSASRQSYRVGSPALAGPPE-PLQPQNQAQLAPSPLSPPMLSPPGM 684
Cdd:pfam03154  207 PPQGSPATSQPPNQTQSTaaphTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQvSPQPLPQPSLHGQMPPMPHSLQTGP 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  685 NRslsggIPHLVPGERVnPYAPQTTQQQVPGIPGNARYSPAP--PSAPNTNGTNRPPSASRYSPAPTAsrpPVPAFHAAT 762
Cdd:pfam03154  287 SH-----MQHPVPPQPF-PLTPQSSQSQVPPGPSPAAPGQSQqrIHTPPSQSQLQSQQPPREQPLPPA---PLSMPHIKP 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  763 TPPTVLPHLPRTSSplahfevsreaaatngdHSQPDRRSSYSlePRRVPS-LPTTReveeeddsktsyAAQPANGVPAES 841
Cdd:pfam03154  358 PPTTPIPQLPNPQS-----------------HKHPPHLSGPS--PFQMNSnLPPPP------------ALKPLSSLSTHH 406

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  842 RYSPAPPTV-----ARQTPPPSSHGPPLHSTLSPSKrSTSNYLPQAALHDSPPDNRYAPPPRSQTQSPGSSQGAHPPSQP 916
Cdd:pfam03154  407 PPSAHPPPLqlmpqSQQLPPPPAQPPVLTQSQSLPP-PAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTST 485

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1868502967  917 VPRPTSVHSPTSPRATRSfQPINAPVSRPRGPSQ 950
Cdd:pfam03154  486 SSAMPGIQPPSSASVSSS-GPVPAAVSCPLPPVQ 518
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 1516-1711 5.23e-04

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 45.45  E-value: 5.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1516 PATRAAsrYAPGPSQtplSSSYEPGAGYTPGPASVGRSSNEYSRSPYeprtsmdSQPGYSNGGYM-PQNATAPsqgYTPP 1594
Cdd:PTZ00395   373 PDARGA--WAGGPHS---NASYNCAAYSNAAQSNAAQSNAGFSNAGY-------SNPGNSNPGYNnAPNSNTP---YNNP 437

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1595 MYgggqdttasaqvlsgavQNSPMQSPTkpeyqgyepygsqdppvpsvevqsqeaagNSQQPNNNL--ANSGYQPPSYGY 1672
Cdd:PTZ00395   438 PN-----------------SNTPYSNPP-----------------------------NSNPPYSNLpySNTPYSNAPLSN 471

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1868502967 1673 EPPSMSNDEPQSQSAEPTEGGGYEPPTFQPYGYEPPSYN 1711
Cdd:PTZ00395   472 APPSSAKDHHSAYHAAYQHRAANQPAANLPTANQPAANN 510
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
634-861 7.25e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.48  E-value: 7.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  634 PMASKPRSASRQSYRVGSPALAGPPEPLQPQNQAQLAPSPLSPPMLsppgmnrslsggiphlVPGERVNPYAPQTTQQQV 713
Cdd:PRK12323   376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAA----------------APARRSPAPEALAAARQA 439

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  714 PGIPGNARYSPAPPSAPNTNGTNRPPSASRYSPAPTASRPPVPAFHAATTPPTVLPHLPRTSSP--LAHFEVSREAAATN 791
Cdd:PRK12323   440 SARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPpeFASPAPAQPDAAPA 519

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  792 GDHSQPDRRSSYSLEPRRVPSLPTTReveeeddsktSYAAQPANGVPAESRYSPAPPTVARQTPPPSSHG 861
Cdd:PRK12323   520 GWVAESIPDPATADPDDAFETLAPAP----------AAAPAPRAAAATEPVVAPRPPRASASGLPDMFDG 579
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1478-1692 8.09e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.46  E-value: 8.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1478 AGGTPTISRspsVTNFEPmyGTGATSLPVGSPPAAVP--IPATRAASRYAPGPSQTPLSSSYEPGAGYTPGPASVGRSSN 1555
Cdd:PRK07003   346 AGFTMTLLR---MLAFEP--AVTGGGAPGGGVPARVAgaVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAA 420

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1556 EYSRSPyePRTSMDSQPGYSNGGYMPQNATAPSQGYTPPMYGGGQDTTASAQVLSGAVQNSPmqSPTKPEYQGYEPYGSQ 1635
Cdd:PRK07003   421 TRAEAP--PAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAP--ASDAPPDAAFEPAPRA 496

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1868502967 1636 DPPVPSVEVQSQEAAGNSQQPNNNlansgyqppsygyEPPSMSNDEPQSQSAEPTEG 1692
Cdd:PRK07003   497 AAPSAATPAAVPDARAPAAASRED-------------APAAAAPPAPEARPPTPAAA 540
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 713-848 1.60e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.55  E-value: 1.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  713 VPGIPGNARYSPAPPSAPntngtnrPPSASRYSPA--PTASRPPVPAFHAATTPPTVLPHLPRTSSPLAhfeVSREAAAT 790
Cdd:PRK14951   370 AEAAAPAEKKTPARPEAA-------APAAAPVAQAaaAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAA---AAPAAAPA 439

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1868502967  791 NGDHSQPDRRSSYSLEPRRVPSLPTTREVEEEDDSktsyAAQPANGVPAESRYSPAPP 848
Cdd:PRK14951   440 AAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVAS----AAPAPAAAPAAARLTPTEE 493
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 825-920 1.83e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.16  E-value: 1.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  825 SKTSYAAQPANGVPAESRYSPAPPTVArqTPPPSSHGPPLHSTLSPSKRSTSNYLPQAALHDSPPDNRyAPPPRSQTQSP 904
Cdd:PRK14951   395 AQAAAAPAPAAAPAAAASAPAAPPAAA--PPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETV-AIPVRVAPEPA 471

                           90
                   ....*....|....*.
gi 1868502967  905 GSSQGAHPPSQPVPRP 920
Cdd:PRK14951   472 VASAAPAPAAAPAAAR 487
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
1059-1145 1.84e-03

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 42.99  E-value: 1.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1059 VSFQPQLSHEHKRAIERLLLW---KIL----RVFVEHDGVLEGTTAVDKAVRDVLAPGVDADANEGTL-GYGAGLGADAL 1130
Cdd:COG1231    259 IEFDPPLPAAKRAAIQRLPYGaaiKVFlqfdRPFWEEDGLYGGISLTDLPIRQTWYPSNGPDGGAGVLlGYVGGDDARAL 338

                           90
                   ....*....|....*
gi 1868502967 1131 QESSSTQMKAEVVDS 1145
Cdd:COG1231    339 AALSPEERVAAALEQ 353
flhF PRK06995
flagellar biosynthesis protein FlhF;
471-549 2.11e-03

flagellar biosynthesis protein FlhF;


Pssm-ID: 235904 [Multi-domain]  Cd Length: 484  Bit Score: 43.03  E-value: 2.11e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1868502967  471 TPTVASHQASSSPYAPTAPAVPSPyqPQNAATSFAPAVAPYTAQRTQSAAPYNAQQTRPEPVKAQSFAAQSKGGYTSPY 549
Cdd:PRK06995    52 APPAAAAPAAAQPPPAAAPAAVSR--PAAPAAEPAPWLVEHAKRLTAQREQLVARAAAPAAPEAQAPAAPAERAAAENA 128
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 481-920 2.24e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 2.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  481 SSPYAPTAPAVPSPYQPQNAATSFAPAVAPYTAQRtQSAAPYNAQQTRPEPVKAqsfaaqskggytspydlpmevvvPKK 560
Cdd:PRK07764   388 AGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAA-PAPAAAPQPAPAPAPAPA-----------------------PPS 443

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  561 RASTNQLPQSPSTGPSSGPPPRSSSMQAPTPPPppraATSSASPPTSSHSGQPPPAGKPVPVLRNKDSFFEELPMA-SKP 639
Cdd:PRK07764   444 PAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEP----TAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLRERwPEI 519

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  640 RSASRQSYRVGSPALAGPPEPLQPQ-NQAQLAPSPLSPPML-SPPGMNRSLSGGIpHLVPGERVnpyapqttqqQVPGIP 717
Cdd:PRK07764   520 LAAVPKRSRKTWAILLPEATVLGVRgDTLVLGFSTGGLARRfASPGNAEVLVTAL-AEELGGDW----------QVEAVV 588

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  718 GNARYSPAPPSAPNTNGTNRPPSASRYSPAPTASRPPVPAFHAATTPPTVLPHLPRTSSPLAHFEVSREAAATNGDHSQP 797
Cdd:PRK07764   589 GPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDG 668

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  798 DRRSSYSLEPRRVPSLPTTreveeeddsktsyAAQPANGVPAESRYSPAPPTVAR--QTPPPSSHGPPLHSTLSPSKRST 875
Cdd:PRK07764   669 WPAKAGGAAPAAPPPAPAP-------------AAPAAPAGAAPAQPAPAPAATPPagQADDPAAQPPQAAQGASAPSPAA 735

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*
gi 1868502967  876 SNYLPQAALHDSPPDNRYAPPPRSQTQSPGSSQGAHPPSQPVPRP 920
Cdd:PRK07764   736 DDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPS 780
PHA03378 PHA03378
EBNA-3B; Provisional
 738-947 2.35e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.13  E-value: 2.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  738 PPSASRYSPAPTASRPPVPAFHAATTP--PTVLPHLPRTSSPlahfevSREAAATNGDHSQPDRRSSYSLEP--RRVPSL 813
Cdd:PHA03378   580 PTTSQLASSAPSYAQTPWPVPHPSQTPepPTTQSHIPETSAP------RQWPMPLRPIPMRPLRMQPITFNVlvFPTPHQ 653

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  814 PTTREVEEEDDSKTSYA---AQPANGVPAESRYSPAPPTVARqtPPPSSHGPPLHSTLSPSKRSTSNYLPQAALHDSPPD 890
Cdd:PHA03378   654 PPQVEITPYKPTWTQIGhipYQPSPTGANTMLPIQWAPGTMQ--PPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAP 731

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1868502967  891 NRYAPPPRSQTQS--PGSSQGAHPPSQPVPRPTSVHSPTSPRATRSFQPINAPV--SRPRG 947
Cdd:PHA03378   732 GRARPPAAAPGRArpPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPApqQRPRG 792
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 14-195 2.47e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 2.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967   14 MPNDASGHATTETQVSSSAETHDSPSAPplhSQLAEDVEPTTLPQATQLESKPEEQSTPWLAEDDSQdasddwpvferPV 93
Cdd:pfam05109  454 VPTNLTAPASTGPTVSTADVTSPTPAGT---TSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPT-----------PN 519

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967   94 SDAPAESDDSPKEASTSTTAAEPEPNSFTSTEPANDIAPQPQPVADEAKPSAPTLGHTSTNSFTRTVSHEV-------NW 166
Cdd:pfam05109  520 ATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNAtsptvgeTS 599

                          170       180
                   ....*....|....*....|....*....
gi 1868502967  167 DDDHDTEWTLPRTDTDPFKFMPPNERTNS 195
Cdd:pfam05109  600 PQANTTNHTLGGTSSTPVVTSPPKNATSA 628
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 697-929 2.58e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.75  E-value: 2.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  697 PGERVNPYAPQTTQQqvPGIPGNARYSPAPPSAPNTNGTNRPPSASRYSPAPTASRPPVPAFHAATTPPTVlPHLPRTS- 775
Cdd:PTZ00449   582 PKDPKHPKDPEEPKK--PKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEG-PKIIKSPk 658

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  776 ---SPLAHFEVSREAAATNgdhsqpdrrsSYSLEPRRVPSLPTTREVEEEDDSKTSYAAQPANGVPAESRySPAPPTvaR 852
Cdd:PTZ00449   659 ppkSPKPPFDPKFKEKFYD----------DYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTP-RPLPPK--L 725

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  853 QTPPPSSHGPPLHSTL---SPSKRSTSNYLPQAALHDSPPDNRYAPPPRSQTQSPGSSQGAHPPSQPVPRPTS--VHSPT 927
Cdd:PTZ00449   726 PRDEEFPFEPIGDPDAeqpDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEAMKRPDSpsEHEDK 805


                   ..
gi 1868502967  928 SP 929
Cdd:PTZ00449   806 PP 807
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 881-972 2.94e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 42.62  E-value: 2.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  881 QAALHDSPPDNRYAPPPrsQTQSPGSSQGAHPPSQPVPRPTSVHSPTSPRATRSFQPINAPVSRPRGPSQTfNWVAPTDG 960
Cdd:PRK14954   381 APSPAGSPDVKKKAPEP--DLPQPDRHPGPAKPEAPGARPAELPSPASAPTPEQQPPVARSAPLPPSPQAS-APRNVASG 457

                           90
                   ....*....|..
gi 1868502967  961 RENDSLQRWKGA 972
Cdd:PRK14954   458 KPGVDLGSWQGK 469
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 720-976 3.62e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 42.33  E-value: 3.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  720 ARYSPAPPSAPNTNGTNRPPSASRYSPAPTASRPPVPAFHAAT-----TPPTVLPHL----------PRTSSPLAHFEvs 784
Cdd:pfam09770  100 VRFNRQQPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTgyekyKEPEPIPDLqvdaslwgvaPKKAAAPAPAP-- 177

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  785 rEAAATNGDHSQPDRRSsYSLEprrvpslpttrEVEEEDDSKTSYAAQPANGVPAESRYSPAPPTVARQTPPPSSHGPPL 864
Cdd:pfam09770  178 -QPAAQPASLPAPSRKM-MSLE-----------EVEAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQ 244

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  865 HstlspskrstsnylPQAALHDSPPDNRYAPPPrSQTQSPGSSQGAHPPSQPVPRPTSVH---SPTSPRATRSFQ-PINA 940
Cdd:pfam09770  245 Q--------------PQQQPQQPQQHPGQGHPV-TILQRPQSPQPDPAQPSIQPQAQQFHqqpPPVPVQPTQILQnPNRL 309

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1868502967  941 PVSRPRGPSQTFNWVAPTDGRENDSLQRWKG--APIIS 976
Cdd:pfam09770  310 SAARVGYPQNPQPGVQPAPAHQAHRQQGSFGrqAPIIT 347
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
703-883 3.73e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 3.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  703 PYAPQTTQQQVPGIPGNARYSPAPpsAPNTNGTNRPPSASRYSPAPTASRPPVPAFHAATTPPTVLPHLPRTSSPLAHFE 782
Cdd:PRK12323   407 AAAPAAAAAARAVAAAPARRSPAP--EALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAA 484

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  783 VSREAAATNGDHSQPDRRSSYSLEPRRVPSLPTTREVEEEDDSKTSYAAQPANGVPAESRYSPAP-PTVARQTPPPSSHG 861
Cdd:PRK12323   485 PAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPaPRAAAATEPVVAPR 564

                          170       180
                   ....*....|....*....|..
gi 1868502967  862 PPLHSTLSPSKRSTSNYLPQAA 883
Cdd:PRK12323   565 PPRASASGLPDMFDGDWPALAA 586
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 452-922 4.22e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 42.38  E-value: 4.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  452 PTAAAPAPVVQPAGQQNRYTPTVASHQAS-SSPYAPTAPAVPSPYQPQNAATSFAPAVAPYTAQRTQSAAPYNAQQTRPE 530
Cdd:PRK10263   364 PGPQTGEPVIAPAPEGYPQQSQYAQPAVQyNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVA 443

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  531 PVKAQSFAAQSKGGYTSPYDLPMEVVVPKKRASTNQLPQSPSTGPSSGPPPRSSSMQAPTP-----PPPPRAATSSASPP 605
Cdd:PRK10263   444 GNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEETKPARPplyyfEEVEEKRAREREQL 523

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  606 TSSHSGQPPPAGKPVPVLrnkdsffEELPMASKPRSASRQSYRVGSPALAGppeplqpQNQAQLAPSPLSPPMLSPPGMn 685
Cdd:PRK10263   524 AAWYQPIPEPVKEPEPIK-------SSLKAPSVAAVPPVEAAAAVSPLASG-------VKKATLATGAAATVAAPVFSL- 588

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  686 rsLSGGIPHLVPGERVNPYAPQTTQQQVPGIPGNARYSPAPPSAPNTNGTNRPPSASRYSPAPTASRPPVPAFH------ 759
Cdd:PRK10263   589 --ANSGGPRPQVKEGIGPQLPRPKRIRVPTRRELASYGIKLPSQRAAEEKAREAQRNQYDSGDQYNDDEIDAMQqdelar 666

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  760 --AATTPPTV-------LPHLPRTSSPLAHFEVSREAAAT-----NGDH---SQPDRRSSYSLEPRRV-----PSLPT-T 816
Cdd:PRK10263   667 qfAQTQQQRYgeqyqhdVPVNAEDADAAAEAELARQFAQTqqqrySGEQpagANPFSLDDFEFSPMKAllddgPHEPLfT 746

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  817 REVEEEDDSKTSYAAQPANGVPAEsrysPAPPTVARQTP----PPSSHGPPLHSTLSPSKRSTSNYLPQA--ALHDSPPD 890
Cdd:PRK10263   747 PIVEPVQQPQQPVAPQQQYQQPQQ----PVAPQPQYQQPqqpvAPQPQYQQPQQPVAPQPQYQQPQQPVApqPQYQQPQQ 822

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|..
gi 1868502967  891 NRYAPPPRSQTQSPGSSQGA----HP------PSQPVPRPTS 922
Cdd:PRK10263   823 PVAPQPQYQQPQQPVAPQPQdtllHPllmrngDSRPLHKPTT 864
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 705-789 5.00e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 41.72  E-value: 5.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  705 APQTTQQQVPgIPGNARYSPAPPSAPNTNGTNRPPSAS-RYSPAPTASRPPVPAFHAATTPPTVLPHLPRTSSPLahfEV 783
Cdd:PRK14950   365 APQPAKPTAA-APSPVRPTPAPSTRPKAAAAANIPPKEpVRETATPPPVPPRPVAPPVPHTPESAPKLTRAAIPV---DE 440


                   ....*.
gi 1868502967  784 SREAAA 789
Cdd:PRK14950   441 KPKYTP 446
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 650-973 5.09e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 5.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  650 GSPALAGPPEPLQPQNQAQLAPSPLSPPMLSPPGMNRSLSGGIPHLVPGERVNPYAPQTTQQQVPGIPGnARYSPAPPSA 729
Cdd:PRK07764   409 APAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPT-AAPAPAPPAA 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  730 PNTNGTNRPPSASRYSPAPTASRPP--------------VPAFHAATTP-PTVLP------HLPRTSSPLAHF------- 781
Cdd:PRK07764   488 PAPAAAPAAPAAPAAPAGADDAATLrerwpeilaavpkrSRKTWAILLPeATVLGvrgdtlVLGFSTGGLARRfaspgna 567

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  782 EVSREAAA--TNGDHsqpdrRSSYSLEPRRVPSLPTTREVEEEDDSkTSYAAQPANGVPAESRYSPAPPTVARQTPPPSS 859
Cdd:PRK07764   568 EVLVTALAeeLGGDW-----QVEAVVGPAPGAAGGEGPPAPASSGP-PEEAARPAAPAAPAAPAAPAPAGAAAAPAEASA 641

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  860 HGPPLHSTLSPSKRSTSNYLPQAALHDSPPDNRYAPP-PRSQTQSPGSSQGAHPPSQPVPRPTSVHSPTSPRATRSfQPI 938
Cdd:PRK07764   642 APAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPaAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDP-AAQ 720

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 1868502967  939 NAPVSRPRGPSQTFNWVAPTDGRENDSLQRWKGAP 973
Cdd:PRK07764   721 PPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAP 755
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 828-969 5.91e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.61  E-value: 5.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  828 SYAAQPANGVPAESRYS----PAPPTVARQTPPPSSHGPPLHSTLSPSKRSTSNYLPQAALHDSPPDNRYAPPPRSQTQS 903
Cdd:PRK10263   379 GYPQQSQYAQPAVQYNEplqqPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAP 458

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1868502967  904 PGSSQGAHPPSQPVPRPTSVHSPTS--PRATRSFQPINAPVSRPRGPSQTFNWVAPTDGRENDSLQRW 969
Cdd:PRK10263   459 QSTYQTEQTYQQPAAQEPLYQQPQPveQQPVVEPEPVVEETKPARPPLYYFEEVEEKRAREREQLAAW 526
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1487-1906 6.52e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 6.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1487 SPSVTNFEPMyGTGATSLPVGSPPAAVPIPATRAASRYAPGPSQTPLSSSYEPGAGYTPGPASVGrSSNEYSRSPYEPRT 1566
Cdd:PHA03247  2630 SPSPAANEPD-PHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVG-SLTSLADPPPPPPT 2707

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1567 SMDSQPGYSNGGYMPQNATAPSQGYTPPMYGGGQDTTASAQVLSGAVQNSPMQSPTKPEYQGYEPYGSQDPPVPSVEVqs 1646
Cdd:PHA03247  2708 PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR-- 2785

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1647 qeAAGNSQQPNNNLANSGYQPPSYGYEPPSMSNDEPQSQSAEPTEGggyEPPTFQPYGYEPPSYNPEPEQDDEG------ 1720
Cdd:PHA03247  2786 --PAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLP---PPTSAQPTAPPPPPGPPPPSLPLGGsvapgg 2860

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1721 --ESRPKPKSfmddddDDDIPALKALKPQEKGKSEKDKENEEMFKKAAEEDAKRAAAQQQSKKGWGFGSWFGGKKEASPD 1798
Cdd:PHA03247  2861 dvRRRPPSRS------PAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP 2934

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967 1799 PQQQGNKPVK-----ANLGESSSFVYDPDLKRWVnkKGGAEATQAKTATPPPPKGAPRSntgtpppprtmtppmgrASAP 1873
Cdd:PHA03247  2935 PPPRPQPPLApttdpAGAGEPSGAVPQPWLGALV--PGRVAVPRFRVPQPAPSREAPAS-----------------STPP 2995

                          410       420       430
                   ....*....|....*....|....*....|...
gi 1868502967 1874 PGGPPGPALAHAASNESLGVPPGPRPPSMMRSV 1906
Cdd:PHA03247  2996 LTGHSLSRVSSWASSLALHEETDPPPVSLKQTL 3028
PHA03247 PHA03247
large tegument protein UL36; Provisional
 692-929 8.18e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 8.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  692 IPHLVPGERVNPYAPQTTQQQVPGIPGNARYSPAPPSapntngtnrPPSASRysPAPTASRPP-VPAFHAATTPPTVLPH 770
Cdd:PHA03247   244 ISHPLRGDIAAPAPPPVVGEGADRAPETARGATGPPP---------PPEAAA--PNGAAAPPDgVWGAALAGAPLALPAP 312

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  771 LPRTSSPLAHfevsrEAAATNGDHS---------QPDRRSSYSLEPRRVPSLPTTREVEEeddsKTSYAAQPANGVPAES 841
Cdd:PHA03247   313 PDPPPPAPAG-----DAEEEDDEDGamevvsplpRPRQHYPLGFPKRRRPTWTPPSSLED----LSAGRHHPKRASLPTR 383

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  842 RYSPAPPTVARQTPPPSSHGPPLHSTLSPSKRSTSNYLPQAALHDSPPDNryaPPPRSQtqsPGSSQGAHPPSQPVPrPT 921
Cdd:PHA03247   384 KRRSARHAATPFARGPGGDDQTRPAAPVPASVPTPAPTPVPASAPPPPAT---PLPSAE---PGSDDGPAPPPERQP-PA 456


                   ....*...
gi 1868502967  922 SVHSPTSP 929
Cdd:PHA03247   457 PATEPAPD 464
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 693-768 9.78e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 40.87  E-value: 9.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868502967  693 PHLVP----GERVNPyAPQTTQQQV----PGIPGNARYSPAP-PSAPNTNGTNRPPsASRYSPAPTASRPPVPAFHAATT 763
Cdd:PHA03269    70 LAQAPtpaaSEKFDP-APAPHQAASrapdPAVAPQLAAAPKPdAAEAFTSAAQAHE-APADAGTSAASKKPDPAAHTQHS 147


                   ....*
gi 1868502967  764 PPTVL 768
Cdd:PHA03269   148 PPPFA 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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