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Conserved domains on  [gi|1907184352|ref|XP_036009356|]
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zinc finger protein 569 isoform X2 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
79-512 3.59e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.81  E-value: 3.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352  79 KLYECHQCGKGFSHKEKLINHHKLHSREQCYECS--ECGKTFIKMSNLIRHQRIHTGEKPYVC-QECGKSFGQKSNLIDH 155
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352 156 EKIHTGEKPYKCNECGKSFSQKQSLV--AHQKVHTGEKP-YACNECGKAFPRVASLALHMRGHtgekpykcdkcgkafsq 232
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPlPGNNSSSVNTPQSNSLHPPLPAN----------------- 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352 233 fsmliihvrvHTGEKPYECgecgkafsqsSALTVHIRSHTGEKPYECKECRKSFSHKKNFITHQKIHTREKPYGCNECGK 312
Cdd:COG5048   175 ----------SLSKDPSSN----------LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQ 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352 313 AFIQMSNLVRHQRIHTGEKPYLCKECGKAFSQKSNLIAHEKIHSGE-------KPYECNECGKAFSQKQNFITHQ--KVH 383
Cdd:COG5048   235 LSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNH 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352 384 TGE--KPYDC--NKCGKAFSQIASLTLHLRSHTGEKPYEC--EKCGKAFSQ----CSLLNLHMRSH-TGEKPYVC--NEC 450
Cdd:COG5048   315 SGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPllnnEPPQSLQQYKDlKNDKKSETlsNSC 394

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907184352 451 GKAFSQRTSLIVHMRGHTGEKPYECN--KCGKAFSQSSSLTIHIRGHTGEKPFDCSNCGKAFSQ 512
Cdd:COG5048   395 IRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
zf-H2C2_2 pfam13465
Zinc-finger double domain;
515-540 5.87e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.87e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907184352 515 SLTLHMRKHTGEKPYVCIECGKAFSQ 540
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
79-512 3.59e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.81  E-value: 3.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352  79 KLYECHQCGKGFSHKEKLINHHKLHSREQCYECS--ECGKTFIKMSNLIRHQRIHTGEKPYVC-QECGKSFGQKSNLIDH 155
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352 156 EKIHTGEKPYKCNECGKSFSQKQSLV--AHQKVHTGEKP-YACNECGKAFPRVASLALHMRGHtgekpykcdkcgkafsq 232
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPlPGNNSSSVNTPQSNSLHPPLPAN----------------- 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352 233 fsmliihvrvHTGEKPYECgecgkafsqsSALTVHIRSHTGEKPYECKECRKSFSHKKNFITHQKIHTREKPYGCNECGK 312
Cdd:COG5048   175 ----------SLSKDPSSN----------LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQ 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352 313 AFIQMSNLVRHQRIHTGEKPYLCKECGKAFSQKSNLIAHEKIHSGE-------KPYECNECGKAFSQKQNFITHQ--KVH 383
Cdd:COG5048   235 LSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNH 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352 384 TGE--KPYDC--NKCGKAFSQIASLTLHLRSHTGEKPYEC--EKCGKAFSQ----CSLLNLHMRSH-TGEKPYVC--NEC 450
Cdd:COG5048   315 SGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPllnnEPPQSLQQYKDlKNDKKSETlsNSC 394

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907184352 451 GKAFSQRTSLIVHMRGHTGEKPYECN--KCGKAFSQSSSLTIHIRGHTGEKPFDCSNCGKAFSQ 512
Cdd:COG5048   395 IRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
zf-H2C2_2 pfam13465
Zinc-finger double domain;
319-344 2.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.31e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907184352 319 NLVRHQRIHTGEKPYLCKECGKAFSQ 344
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
515-540 5.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.87e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907184352 515 SLTLHMRKHTGEKPYVCIECGKAFSQ 540
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 135-187 2.59e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 2.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907184352 135 KPYvCQECGKSFGQKSNLIDHEKIHTgekpYKCNECGKSFSQKQSLVAH-QKVH 187
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
79-512 3.59e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.81  E-value: 3.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352  79 KLYECHQCGKGFSHKEKLINHHKLHSREQCYECS--ECGKTFIKMSNLIRHQRIHTGEKPYVC-QECGKSFGQKSNLIDH 155
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352 156 EKIHTGEKPYKCNECGKSFSQKQSLV--AHQKVHTGEKP-YACNECGKAFPRVASLALHMRGHtgekpykcdkcgkafsq 232
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPlPGNNSSSVNTPQSNSLHPPLPAN----------------- 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352 233 fsmliihvrvHTGEKPYECgecgkafsqsSALTVHIRSHTGEKPYECKECRKSFSHKKNFITHQKIHTREKPYGCNECGK 312
Cdd:COG5048   175 ----------SLSKDPSSN----------LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQ 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352 313 AFIQMSNLVRHQRIHTGEKPYLCKECGKAFSQKSNLIAHEKIHSGE-------KPYECNECGKAFSQKQNFITHQ--KVH 383
Cdd:COG5048   235 LSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNH 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352 384 TGE--KPYDC--NKCGKAFSQIASLTLHLRSHTGEKPYEC--EKCGKAFSQ----CSLLNLHMRSH-TGEKPYVC--NEC 450
Cdd:COG5048   315 SGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPllnnEPPQSLQQYKDlKNDKKSETlsNSC 394

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907184352 451 GKAFSQRTSLIVHMRGHTGEKPYECN--KCGKAFSQSSSLTIHIRGHTGEKPFDCSNCGKAFSQ 512
Cdd:COG5048   395 IRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
163-547 5.25e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 5.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352 163 KPYKCNECGKSFSQKQSLVAHQKVHTGEKPYACN--ECGKAFPRVASLALHMRGHTGEKPYKCDK--------------- 225
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352 226 -CGKAFSQFSMLIIHVRVHTGEKPYECGECGKAFSQSSALTVHIRSHTGEK-------PYECKECRKSFSHKKNFITHQK 297
Cdd:COG5048   112 sSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352 298 IHTREKPYGCNECGKAFIQMSNLVRHQRIHTGEKPYLCKECGKAFSQKSNLIAHEKIHSGEKPYECNECGKAFSQKQNFI 377
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352 378 THQKVHTGE-------KPYDCNKCGKAFSQIASLTLHLRS--HTGE--KPYEC--EKCGKAFSQCSLLNLHMRSHTGEKP 444
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352 445 YVC--NECGKAFSQ-----RTSLIVHMRGHTGEKPYEC--NKCGKAFSQSSSLTIHIRGHTGEKP--FDCSNCGKAFSQI 513
Cdd:COG5048   352 AKEklLNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1907184352 514 SSLTLHMRKHTgEKPYVCIECGKAFSQKSHLVRH 547
Cdd:COG5048   432 YNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
303-553 3.60e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 3.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352 303 KPYGCNECGKAFIQMSNLVRHQRIHTGEKPYLC--KECGKAFSQKSNLIAHEKIHSGEKP-------------------- 360
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSdlnskslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352 361 -------YECNECGKAFSQKQNFITHQKVHT-----GEKPYDCNKCGKAFSQIASL-------------------TLHLR 409
Cdd:COG5048   112 ssssnsnDNNLLSSHSLPPSSRDPQLPDLLSisnlrNNPLPGNNSSSVNTPQSNSLhpplpanslskdpssnlslLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352 410 SHTGEKPYECEKCGKAFSQCSLLNLHMRSHTGEKPYVCNECGKAF------SQRTSLIVHMRGHTGEKPYECNKCGKAFS 483
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907184352 484 QSSSLTIHIRGHTG-EKPFDCSNCGKAFSQISSLTLHMRK--HTGE--KPYVC--IECGKAFSQKSHLVRHQRIHTH 553
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
319-344 2.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.31e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907184352 319 NLVRHQRIHTGEKPYLCKECGKAFSQ 344
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
515-540 5.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.87e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907184352 515 SLTLHMRKHTGEKPYVCIECGKAFSQ 540
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
151-176 6.04e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.04e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907184352 151 NLIDHEKIHTGEKPYKCNECGKSFSQ 176
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
123-146 6.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.35e-04
                          10        20
                  ....*....|....*....|....
gi 1907184352 123 NLIRHQRIHTGEKPYVCQECGKSF 146
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
432-456 7.21e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.21e-04
                          10        20
                  ....*....|....*....|....*
gi 1907184352 432 LNLHMRSHTGEKPYVCNECGKAFSQ 456
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
207-232 8.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.95e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907184352 207 SLALHMRGHTGEKPYKCDKCGKAFSQ 232
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
263-288 1.37e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.37e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907184352 263 ALTVHIRSHTGEKPYECKECRKSFSH 288
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
459-484 2.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.58e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907184352 459 SLIVHMRGHTGEKPYECNKCGKAFSQ 484
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 135-187 2.59e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 2.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907184352 135 KPYvCQECGKSFGQKSNLIDHEKIHTgekpYKCNECGKSFSQKQSLVAH-QKVH 187
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
403-428 2.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.61e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907184352 403 SLTLHLRSHTGEKPYECEKCGKAFSQ 428
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
39-211 2.84e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 2.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352  39 QPFHTSSPHFVLTPFKCNHCGKGFSQTLDLIRHLR--VHTGGKLYECHQ----CGKGFSHKEKLINHHKLH----SREQC 108
Cdd:COG5048   276 NESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHtsisPAKEK 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907184352 109 YEcsECGKTFIKMSN-----LIRHQRIHTGEKPYVC--QECGKSFGQKSNLIDHEKIHTGEKP--YKCNECGKSFSQKQS 179
Cdd:COG5048   356 LL--NSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1907184352 180 LVAHQKVHTgEKPYACNECGKAFPRVASLALH 211
Cdd:COG5048   434 LIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
347-372 4.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.48e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907184352 347 NLIAHEKIHSGEKPYECNECGKAFSQ 372
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
235-260 8.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.83e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907184352 235 MLIIHVRVHTGEKPYECGECGKAFSQ 260
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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