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Conserved domains on  [gi|1907079533|ref|XP_036012105|]
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monocarboxylate transporter 7 isoform X4 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 108-465 7.18e-145

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17422:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 363  Bit Score: 420.31  E-value: 7.18e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTA--ITALKEHIGWRYSLLFVGLLQLN 185
Cdd:cd17422     1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAplSTVLSNRFGHRPVVMVGGLLISL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 186 IMVCGALLRPI--------IIQGPGQSpkaVTLEPRREV--QYMlenEKTRTSIDSIDSGVELTTSPKNVPSEAKMEQET 255
Cdd:cd17422    81 GMITASFASSIvemyltigIISGLGYC---FTFLPTVTIlsQYF---KKRRSLVTAIASTGECFAVFAFAPAFTALKESI 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 256 RAEQQQTLVTAPKHSQMKAPLLdFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVF 335
Cdd:cd17422   155 GWRYCLLVVGALQLNIVVCGAL-LRVLKEPGFICYALFGLFATLGFFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELF 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 336 GRIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEDDVVGIEKMSSAA 415
Cdd:cd17422   234 GRISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVAGTHIPLLAEDDVVGIEKMSSAL 313

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907079533 416 GVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 465
Cdd:cd17422   314 GVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLALVR 363
 
Name Accession Description Interval E-value
MFS_MCT7 cd17422
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ...
 108-465 7.18e-145

Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340980 [Multi-domain]  Cd Length: 363  Bit Score: 420.31  E-value: 7.18e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTA--ITALKEHIGWRYSLLFVGLLQLN 185
Cdd:cd17422     1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAplSTVLSNRFGHRPVVMVGGLLISL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 186 IMVCGALLRPI--------IIQGPGQSpkaVTLEPRREV--QYMlenEKTRTSIDSIDSGVELTTSPKNVPSEAKMEQET 255
Cdd:cd17422    81 GMITASFASSIvemyltigIISGLGYC---FTFLPTVTIlsQYF---KKRRSLVTAIASTGECFAVFAFAPAFTALKESI 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 256 RAEQQQTLVTAPKHSQMKAPLLdFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVF 335
Cdd:cd17422   155 GWRYCLLVVGALQLNIVVCGAL-LRVLKEPGFICYALFGLFATLGFFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELF 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 336 GRIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEDDVVGIEKMSSAA 415
Cdd:cd17422   234 GRISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVAGTHIPLLAEDDVVGIEKMSSAL 313

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907079533 416 GVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 465
Cdd:cd17422   314 GVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLALVR 363
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
 101-501 1.18e-41

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 154.90  E-value: 1.18e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 101 QVPDGGWGWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTA--ITALKEHIGWRYSLLF 178
Cdd:TIGR00892  10 PPPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGpiSSILVNRFGCRPVVIA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 179 VGLLQLNIMVCGALLRPII--------IQGPGQspkAVTLEP----------RREV---------------------QYM 219
Cdd:TIGR00892  90 GGLLASLGMILASFSSNVIelyltagfITGLGL---AFNFQPsltmlgkyfyRRRPlanglamagspvflstlaplnQYL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 220 LENEKTRTS--------IDSIDSGV---ELTTSPKNVPSEAK--MEQETRAEQQQTLVTAPKHSQmkapLLDFSVLKEKS 286
Cdd:TIGR00892 167 FESFGWRGSflilggllLHCCVCGAlmrPVGPSQRVSKSKSKegLPPDGSTKKLSKKSTAEKINR----FLDFSLFTHRG 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 287 FICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIELICVILLTASL 366
Cdd:TIGR00892 243 FLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPHVQYLFSFALLFNGL 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 367 --FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYS 444
Cdd:TIGR00892 323 thLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLM--DLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYK 400

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907079533 445 RAFYSCAAGMCLAAVCLALVRPCkkglCQNSHSGENQTDRQRGKAL--QDIPEDFLEMD 501
Cdd:TIGR00892 401 YIFYASGSIVVSAGLFLAIGNYI----NYRLLAKEQKAALEREGARdkKDAEGDSRESE 455
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
286-466 2.18e-17

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 83.77  E-value: 2.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 286 SFICYALFGLFATLGFFAPSLYIIP-LGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIELICVILLTA 364
Cdd:COG2271   181 RFWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAAL 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 365 SLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKiYS 444
Cdd:COG2271   261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAE--LFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQ 337

                         170       180
                  ....*....|....*....|..
gi 1907079533 445 RAFYSCAAGMCLAAVCLALVRP 466
Cdd:COG2271   338 AAFLLLAALALLAALLALLLLR 359
MFS_1 pfam07690
Major Facilitator Superfamily;
287-466 1.05e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 69.37  E-value: 1.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 287 FICYALFGLFATLgffAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTASL 366
Cdd:pfam07690   2 FLAAFLAALGRSL---LGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLL--IGLLLFALGL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 367 FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSrA 446
Cdd:pfam07690  77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIA--DWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRA-A 153

                         170       180
                  ....*....|....*....|
gi 1907079533 447 FYSCAAGMCLAAVCLALVRP 466
Cdd:pfam07690 154 FLILAILSLLAAVLLLLPRP 173
 
Name Accession Description Interval E-value
MFS_MCT7 cd17422
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ...
 108-465 7.18e-145

Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340980 [Multi-domain]  Cd Length: 363  Bit Score: 420.31  E-value: 7.18e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTA--ITALKEHIGWRYSLLFVGLLQLN 185
Cdd:cd17422     1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAplSTVLSNRFGHRPVVMVGGLLISL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 186 IMVCGALLRPI--------IIQGPGQSpkaVTLEPRREV--QYMlenEKTRTSIDSIDSGVELTTSPKNVPSEAKMEQET 255
Cdd:cd17422    81 GMITASFASSIvemyltigIISGLGYC---FTFLPTVTIlsQYF---KKRRSLVTAIASTGECFAVFAFAPAFTALKESI 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 256 RAEQQQTLVTAPKHSQMKAPLLdFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVF 335
Cdd:cd17422   155 GWRYCLLVVGALQLNIVVCGAL-LRVLKEPGFICYALFGLFATLGFFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELF 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 336 GRIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEDDVVGIEKMSSAA 415
Cdd:cd17422   234 GRISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVAGTHIPLLAEDDVVGIEKMSSAL 313

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907079533 416 GVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 465
Cdd:cd17422   314 GVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLALVR 363
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 108-465 2.71e-64

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 213.18  E-value: 2.71e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTA--ITALKEHIGWRYSLLFVGLLQLN 185
Cdd:cd17352     1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGplSSALVNRFGCRPVAIAGGLLAAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 186 IMV----CGALLRPIIIQGPGQ--------SPKAVTLEprrevQYMLENEKTRTSIDSIDSGVELTTspknVPSEAKMEQ 253
Cdd:cd17352    81 GLLlssfATSLWQLYLTYGVLGglglgliySPAIVIVG-----QYFEKKRGLATGIAVAGSGVGTFV----FPPLLRYLL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 254 ETRAEQQQTLVTApkhsQMKAPLLDFS----VLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTM 329
Cdd:cd17352   152 DNYGWRGALLILG----GLCLNLCVCGlllrLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSII 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 330 AIAEVFGRIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIE 409
Cdd:cd17352   228 GISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILA--DLVGLE 305

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907079533 410 KMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 465
Cdd:cd17352   306 KLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
 101-501 1.18e-41

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 154.90  E-value: 1.18e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 101 QVPDGGWGWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTA--ITALKEHIGWRYSLLF 178
Cdd:TIGR00892  10 PPPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGpiSSILVNRFGCRPVVIA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 179 VGLLQLNIMVCGALLRPII--------IQGPGQspkAVTLEP----------RREV---------------------QYM 219
Cdd:TIGR00892  90 GGLLASLGMILASFSSNVIelyltagfITGLGL---AFNFQPsltmlgkyfyRRRPlanglamagspvflstlaplnQYL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 220 LENEKTRTS--------IDSIDSGV---ELTTSPKNVPSEAK--MEQETRAEQQQTLVTAPKHSQmkapLLDFSVLKEKS 286
Cdd:TIGR00892 167 FESFGWRGSflilggllLHCCVCGAlmrPVGPSQRVSKSKSKegLPPDGSTKKLSKKSTAEKINR----FLDFSLFTHRG 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 287 FICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIELICVILLTASL 366
Cdd:TIGR00892 243 FLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPHVQYLFSFALLFNGL 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 367 --FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYS 444
Cdd:TIGR00892 323 thLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLM--DLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYK 400

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907079533 445 RAFYSCAAGMCLAAVCLALVRPCkkglCQNSHSGENQTDRQRGKAL--QDIPEDFLEMD 501
Cdd:TIGR00892 401 YIFYASGSIVVSAGLFLAIGNYI----NYRLLAKEQKAALEREGARdkKDAEGDSRESE 455
MFS_MCT11_13 cd17423
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ...
 108-461 2.07e-31

Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340981 [Multi-domain]  Cd Length: 383  Bit Score: 124.81  E-value: 2.07e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFV------------------------------ 157
Cdd:cd17423     1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVqqlaspvgsalstrygarpvvmlggllssl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 158 ---------------------------LTFTAITA----------------------------------LKEHIGWRYSL 176
Cdd:cd17423    81 gfllasfatsllhlylcigllsglgwaLVFAPTMAtvsryfsrrrslatglaltgvglssfalsplfqlLLDTYAWRGAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 177 LFVGLLQLNIMVCGALLRPIIIQGpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 256
Cdd:cd17423   161 LLLSALSLHLVPCGALLRPLALPG-------------------------------------------------------- 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 257 aeqqqtlvTAPKHSQMKAPLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 336
Cdd:cd17423   185 --------DPPAPPRSLSAAFGLSLLTHRAFLRYALATTLINTGYFIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVG 256

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 337 RIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAG 416
Cdd:cd17423   257 RLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAGALAPLVFSVLPE--LVGVERVLNATG 334

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1907079533 417 VYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCL 461
Cdd:cd17423   335 LLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSLIL 379
MFS_MCT3_4 cd17430
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ...
 108-463 3.36e-26

Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340988 [Multi-domain]  Cd Length: 368  Bit Score: 109.82  E-value: 3.36e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTA--ITALKEHIGWRYSLLFVGLLQLN 185
Cdd:cd17430     1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGplCSILVNRFGCRPVMLVGGLLASL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 186 IMVCGALLRPII--------IQGPGQspkAVTLEPRrevQYMLEN--EKTRtsidSIDSGVELTTSPKNVPSEAKMEQET 255
Cdd:cd17430    81 GMILASFCTSIIqlyltagvITGLGL---ALNFQPS---LIMLGRyfDKRR----PLANGLAAAGSPVFLSALSPLGQIL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 256 RAE---------QQQTLVTAPKHSQMKAPLlDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLL 326
Cdd:cd17430   151 LEEygwrggfliLGGLLLNCCTCGAVMRPL-DFSVFRDRGFVIYTIAKFIMVLGLFVPPIFVVNYAKDIGVPDTEAAFLL 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 327 STMAIAEVFGRIGAGFVLNREPIRKIYIELICVILLTASL--FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEdd 404
Cdd:cd17430   230 SILGFIDIFARPACGVVAGLKWVRPRVVYLFSFAMLFNGLtdLCSATAADYGGLVVFCVFFGISYGMVGALQFEVLMA-- 307

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907079533 405 VVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLAL 463
Cdd:cd17430   308 IVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALFLAL 366
MFS_MCT6 cd17425
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ...
 108-463 4.63e-24

Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340983 [Multi-domain]  Cd Length: 364  Bit Score: 103.70  E-value: 4.63e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTA--ITALKEHIGWRYSLLFVGLLQLN 185
Cdd:cd17425     1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGplCSILVERFGCRVTVMLGGLLSGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 186 IMVCGALLRPI--------IIQGPG-----QSpkAVTLEPrrevQYMLENEKTRTSIDSIDSGVELTTspknVPSEAKME 252
Cdd:cd17425    81 GMVASSFSHSIvqlyftagFITGLGfcfsfQS--SVTVLG----FYFVRRRALANALASTGTSIGLTL----WPLLSQYL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 253 QETRAEQQQTLVtapkhsqMKAPLLDFSV--------LKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAF 324
Cdd:cd17425   151 LEEMGWRGSFLV-------FGGVLLNCCVcgavmrpfCSNTRYQIYTLGVTWMVLGFVLPLIYLVPYATSNGMDESKAAL 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 325 LLSTMAIAEVFGRIGAGfVLNREPI---RKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLA 401
Cdd:cd17425   224 LLSILGFINIFMRPLAG-LLSGLPVfkgRRIYLFSLALLLNGLSNLICAISASFPVLLVYCLLYSISMSGIGSLIFQVLM 302

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907079533 402 edDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLAL 463
Cdd:cd17425   303 --DTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALFMGL 362
MFS_MCT5 cd17421
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ...
 108-464 1.12e-22

Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340979 [Multi-domain]  Cd Length: 369  Bit Score: 99.51  E-value: 1.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISIcVFVLTFTA---ITALKEHIGWRYSLLFVGLLql 184
Cdd:cd17421     1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSI-MSSLRLSAgplASVACGRLGERWTSILGAFL-- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 185 nimVCGALLRPI-------------IIQGPG-----QSPKAVTleprreVQYMLENEKTRTSIDSIDSGVELTTSPKNvp 246
Cdd:cd17421    78 ---VSAGFLISIfatsvpflyvsmgLLVGLGfaflyQAAAVMT------AKYFKKRLATAYAIARSGMGLTFALAPFT-- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 247 seaKMEQETRAEQQQTLVTAP-----KHSQMKAPLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDR 321
Cdd:cd17421   147 ---QLLLDEYDWQGALLIFGGimlnlVASGMLLRPIDFSLLKDPFFCIYTWSFVFSQLAYFIPYFHLVARARTLGIDPMD 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 322 AAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLA 401
Cdd:cd17421   224 ASFIISVAGITETVAQLASGWIADQNWIKKYHYHKAYLILCGVTNLLAPLATTYPLLMTYAVFFAIFCGGYLALLLPVLV 303

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907079533 402 edDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALV 464
Cdd:cd17421   304 --DLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSSVSFFLE 364
MFS_MCT2 cd17427
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ...
 108-461 1.37e-22

Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340985 [Multi-domain]  Cd Length: 367  Bit Score: 99.12  E-value: 1.37e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTA--ITALKEHIGWRYSLLFVGLLQLN 185
Cdd:cd17427     1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGpiSSILVNKYGSRPVVIAGGLLCSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 186 IMVCGALLRPI--------IIQGPGQspkAVTLEPRREV--QYMLENEktrtsidSIDSGVELTTSPKNVPSEAKMEQET 255
Cdd:cd17427    81 GMISASFCNSVmqlylcigVIGGLGL---AFNLQPALTIigKYFYKKR-------PIANGLAMAGSPVFLSTLAPLNQFL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 256 RAE---------QQQTLVTAPKHSQMKAPLLdfSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLL 326
Cdd:cd17427   151 FNQfgwrgsfliLGGLLLNCCVAGSLMRPLG--PLFKHRGFLIYLSGNVIMFLGFFAPIVFLAPYAKHMGIDEYSAAFLL 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 327 STMAIAEVFGRIGAGFVLNREPIR---------KIYIELICVILLtaslfafTFATEFWGLMLCSVFFGSMVGTIGGTHI 397
Cdd:cd17427   229 SILAFVDMFARPSMGLVANSKWIRpriqyffsfAVMYNGVCHLLC-------PLAEDYTGLVIYAVFFGFAFGMVSSVLF 301

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907079533 398 PMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCL 461
Cdd:cd17427   302 ETLM--DLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIWL 363
MFS_MCT1 cd17426
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ...
 108-461 2.10e-20

Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340984 [Multi-domain]  Cd Length: 374  Bit Score: 93.02  E-value: 2.10e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTA--ITALKEHIGWRYSLLFVGLLQLN 185
Cdd:cd17426     1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGpiSSILVNKYGSRPIMIAGGCLSGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 186 IMVCGALLRPI--------IIQGPGQspkAVTLEPRREV--QYMLENEktrtsidSIDSGVELTTSPKNVPSEAKMEQ-- 253
Cdd:cd17426    81 GLIAASFCNTVeglyfcvgVVGGLGL---AFNLNPALTMigKYFYKKR-------PLANGLAMAGSPVFLSTLAPLNQwf 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 254 -ETRAEQQQTLVTAP-------KHSQMK----APLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDR 321
Cdd:cd17426   151 fDIFGWRGSFLILGGlllnccvAGSLMRpigpKPFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSNYAKSKQISNES 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 322 AAFLLSTMAIAEVFGRIGAGFVLNREPIR-KI-YIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPM 399
Cdd:cd17426   231 AAFLLSILAFVDMVARPSMGIVANTKWVRpRIqYFFAASVLYNGVCHLLAPLSTSYVGFCIYAIFFGFAFGWLSSVLFET 310

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907079533 400 LAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCL 461
Cdd:cd17426   311 LM--DLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIYL 370
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
286-466 2.18e-17

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 83.77  E-value: 2.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 286 SFICYALFGLFATLGFFAPSLYIIP-LGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIELICVILLTA 364
Cdd:COG2271   181 RFWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAAL 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 365 SLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKiYS 444
Cdd:COG2271   261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAE--LFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQ 337

                         170       180
                  ....*....|....*....|..
gi 1907079533 445 RAFYSCAAGMCLAAVCLALVRP 466
Cdd:COG2271   338 AAFLLLAALALLAALLALLLLR 359
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
273-465 2.47e-17

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 83.78  E-value: 2.47e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 273 KAPLLDF-SVLKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIR 350
Cdd:COG2223   192 KASLRDQlEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDqFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGR 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 351 KIYieLICVILLTASLFAFTFATE-FWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAG 429
Cdd:COG2223   272 RVL--LIVFALMALGLLLLALALGsLWLFLVLFLLLGLALGGGNGAVFALVP--DIFPTKNAGAVYGLVGAAGGLGGFLG 347

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1907079533 430 PPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 465
Cdd:COG2223   348 PLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLY 383
MFS_MCT12 cd17424
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ...
 287-465 2.27e-15

Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340982 [Multi-domain]  Cd Length: 363  Bit Score: 77.54  E-value: 2.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 287 FICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIyielicvilltaSL 366
Cdd:cd17424   185 FLVLAVSVLFLAYGCSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKY------------RY 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 367 FAFTFATEFWGLmlCSVF------------FGSMVGTIGGTHIPML--AEDDVVGIEKMSSAAGVYVFIQSISGLAGPPL 432
Cdd:cd17424   253 FCYLFAVGMDGL--CCLFlpilktfpllvpFSFTFGYFDGAYVALIpvVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPI 330

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1907079533 433 AGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 465
Cdd:cd17424   331 AGWLVDTTGTYTAAFLLSGFSMIFSSLLLGSAR 363
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
285-466 6.90e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 73.08  E-value: 6.90e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 285 KSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYieLICVILLTA 364
Cdd:COG2814    10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL--LLGLLLFAL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 365 SLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYS 444
Cdd:COG2814    88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIA--DLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165

                         170       180
                  ....*....|....*....|..
gi 1907079533 445 rAFYSCAAGMCLAAVCLALVRP 466
Cdd:COG2814   166 -VFLVNAVLALLALLLLLRLLP 186
MFS_1 pfam07690
Major Facilitator Superfamily;
287-466 1.05e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 69.37  E-value: 1.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 287 FICYALFGLFATLgffAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTASL 366
Cdd:pfam07690   2 FLAAFLAALGRSL---LGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLL--IGLLLFALGL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 367 FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSrA 446
Cdd:pfam07690  77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIA--DWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRA-A 153

                         170       180
                  ....*....|....*....|
gi 1907079533 447 FYSCAAGMCLAAVCLALVRP 466
Cdd:pfam07690 154 FLILAILSLLAAVLLLLPRP 173
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 279-461 1.10e-12

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 69.38  E-value: 1.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 279 FSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRK--IYIE 355
Cdd:cd06174   197 KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDlGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKplLLIG 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 356 LICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIggthiPMLAEDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGL 435
Cdd:cd06174   277 LLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPL-----SFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGF 351

                         170       180
                  ....*....|....*....|....*.
gi 1907079533 436 LVDQSKIYSRAFYSCAAGMCLAAVCL 461
Cdd:cd06174   352 LLAATFGLTGAFLVLAVLLLLAAILL 377
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 265-465 1.18e-12

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 69.53  E-value: 1.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 265 TAPKHSQMKAPLLDFSVLKEKSFICYALFGLFATLGFFAP--SLYIIPLGislGIDPDRAAFLLSTMAIAEVFGRIGAGF 342
Cdd:cd17325   181 RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPflPLYAAELG---GLSPAQIGLLFGAQGLASALSQPPAGK 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 343 VLNRePIRKIYIeLICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQ 422
Cdd:cd17325   258 LSDR-IGRKPLI-LIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLA--DIVPPEGRGTAMGLFNTAF 333

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1907079533 423 SISGLAGPPLAGLLVDQSKIYSrAFYSCAAGMCLAAVCLALVR 465
Cdd:cd17325   334 SLGMVLGPLLGGFLYDAFGFAT-PFLAAAALLLLAAVLFLLLR 375
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
280-466 4.70e-12

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 67.59  E-value: 4.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 280 SVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIeLICV 359
Cdd:COG2807   210 SLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLL-LLLG 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 360 ILLTASLFAFTFATEFWgLMLCSVFFGSMVG---TIGGTHIPMLAEDDvvgiekmSSAAGVYVFIQSISGL---AGPPLA 433
Cdd:COG2807   289 LLGLAGLLGLLLAPGSL-PWLWAVLLGLGQGglfPLALTLIGLRARTP-------AEAAALSGMAQSVGYLlaaLGPLLV 360

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1907079533 434 GLLVDQSKIYSRAFYSCAAGMCLAAVC-LALVRP 466
Cdd:COG2807   361 GALHDATGSWTAALLLLAALAVLMLVAgLLAGRP 394
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
279-426 8.60e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 66.54  E-value: 8.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 279 FSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelI 357
Cdd:COG2814   201 RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLL--I 278

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907079533 358 CVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISG 426
Cdd:COG2814   279 GLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAE--LAPPEARGRASGLYNSAFFLGG 345
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 282-465 5.31e-11

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 64.21  E-value: 5.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 282 LKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNRepIRKIYIELICVIL 361
Cdd:cd17355   207 LRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDR--YSPRRLLAASYAL 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 362 LTASLFAFTFATE-FWGLMLCSVFFGSMVGTIGGThIPMLAEdDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQS 440
Cdd:cd17355   285 RALGLALLLLLPFpPLALLLFAALFGLGWGATVPL-TAALAA-RYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRT 362

                         170       180
                  ....*....|....*....|....*
gi 1907079533 441 KIYSRAFYSCAAgMCLAAVCLALVR 465
Cdd:cd17355   363 GSYTAAWALAVA-LGLIAALLVLPI 386
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 288-466 6.85e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 63.75  E-value: 6.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 288 ICYALFGLFATLGFFAPslyIIPLGI-SLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTASL 366
Cdd:cd17325     1 LSLALFLDMLGYGIIIP---ILPLYAeSLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLL--LGLLLLAVST 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 367 FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKiYSRA 446
Cdd:cd17325    76 LLFAFATSYWQLLLARFLQGLASAAVWPAAMALIA--DIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAP 152

                         170       180
                  ....*....|....*....|
gi 1907079533 447 FYSCAAGMCLAAVCLALVRP 466
Cdd:cd17325   153 FLVCAALALLALVLALLLLP 172
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
267-465 6.99e-11

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 64.15  E-value: 6.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 267 PKHSQMKAPLLDF--SVLKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDPDRAAFLLSTMAIAEVFGRIGAGFV 343
Cdd:COG2211   208 PVPEEEKVSLKESlkALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRL 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 344 LNREPIRKIYIelICVILLTASLFAFTFA--TEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVV-------GIEKMSSA 414
Cdd:COG2211   288 AKRFGKKKAFI--IGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLA--DVVdydewktGRRREGLY 363

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907079533 415 AGVYVFIQSISGLAGPPLAGLLVD---------QSKIYSRAFYSC-----AAGMCLAAVCLALVR 465
Cdd:COG2211   364 FGIFTFAIKLGQALAGALAGLLLAlfgyvagaaQSPSALTGIRLLffllpAVLLLLAALLLLFYP 428
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 253-462 1.14e-10

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 63.41  E-value: 1.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 253 QETRAEQQQTLVTAPKHSQMKAPLLDFSVLKeksfICYALFGL----FATLGFFapslyIIPLGISLGIDPDRAAFLLST 328
Cdd:cd17475   172 REPPAASAATESASTLLRSLKEVLRNRDVWL----IAIAGALLvapqFALLTFL-----LLFLHDHLGLSVVAAGALLAV 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 329 MAIAEVFGRIGAGFVLNR--EPIRKIYIELI-CVILLTASLFAF-TFATEFWGLMLCSVFFGsmVGTIG--GTHIPMLAE 402
Cdd:cd17475   243 AQLGGALGRIGLGRVSDRvfGGRRRPVLVITaAIAAAALLVLSLlSPGTPLWLLVLLLILLG--LFAIGwnGLYLTLVAE 320

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 403 ddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLA 462
Cdd:cd17475   321 --SAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
MFS_MCT9 cd17428
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ...
 108-463 1.42e-10

Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340986 [Multi-domain]  Cd Length: 361  Bit Score: 62.91  E-value: 1.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISIC--VFVLTFTAITALKEHIGWRYSLLFVGllqln 185
Cdd:cd17428     1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLAsgVGLIASPVCSACVSSFGARPVTIFSG----- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 186 IMVCGALLRPI-------------IIQGPGQS---PKAVTLEprreVQYMLENEKTRTSIDSIDSGVELTTspknVPSEA 249
Cdd:cd17428    76 FMVAGGLMLSAfapniyflifsygIVVGLGCGlvyAATVTIT----CQYFDKRRGLALGLISTGSSVGLFI----YAALQ 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 250 KMEQETRAEQQQTLVTAPKHSQMKAPLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAF-LLST 328
Cdd:cd17428   148 RELIELYGLDGCLLIVGALALNLLACGSLMRLFKNRVFSALFIAILLFDIGAFPPSLLMEDVARSENIIEEIALIpLVSI 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 329 MAIAEVFGRIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGgthIPMLAEDDVVGI 408
Cdd:cd17428   228 IGITTAIGKLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLSGNWS---IFPYVTTKTVGI 304

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907079533 409 EKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLAL 463
Cdd:cd17428   305 EKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLLLL 359
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
291-464 3.05e-10

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 61.82  E-value: 3.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 291 ALFGLFATLG-FFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYieLICVILLTASLFAF 369
Cdd:COG2223    10 ATLAFFLAFGvWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVL--LIGLLLLGIGLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 370 TFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKiYSRAFYS 449
Cdd:COG2223    88 ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSK--WFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG-WRNAFLI 164

                         170
                  ....*....|....*
gi 1907079533 450 CAAGMCLAAVCLALV 464
Cdd:COG2223   165 LGILLLVVAVLAWLF 179
MFS_MCT14 cd17429
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ...
 285-466 4.80e-10

Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340987 [Multi-domain]  Cd Length: 361  Bit Score: 61.39  E-value: 4.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 285 KSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAF-LLSTMAIAEVFGRIGAGFVLNREPIRKIYIELICVILLT 363
Cdd:cd17429   183 KVFVAFIFWALFAYCSFVIPFIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIFGKVILGIICDLPCISVWNVFILANFTLG 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 364 ASLFAFTFATEFWGLMLCSVFFGSMVGTIggTHIPMLAEDdVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIY 443
Cdd:cd17429   263 VCILILPLMHTYTGLAIVCALIGFSSGYF--SLMPVVTED-LVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKY 339

                         170       180
                  ....*....|....*....|...
gi 1907079533 444 SRAFYSCAAGMCLAAVCLaLVRP 466
Cdd:cd17429   340 DFSFYVCGLLYMVGIICL-LLKP 361
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 290-466 5.54e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 61.29  E-value: 5.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 290 YALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIELICVILLTASLFAf 369
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 370 tFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSR-AFY 448
Cdd:cd06174    80 -FAPSFWLLLLGRFLLGLGSGLIDPAVLALIA--DLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRaVFL 156

                         170
                  ....*....|....*...
gi 1907079533 449 SCAAGMCLAAVCLALVRP 466
Cdd:cd06174   157 IAAALALLAAILLLLVVP 174
MFS_1 pfam07690
Major Facilitator Superfamily;
279-430 6.42e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 60.89  E-value: 6.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 279 FSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNR-EPIRKIYIELI 357
Cdd:pfam07690 194 WKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRlGRRRRLLLALL 273

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907079533 358 CVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGThiPMLAEDDVVGIEKMSSAAGVYVFIQSISGLAGP 430
Cdd:pfam07690 274 LLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPA--LNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
287-439 6.85e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 60.65  E-value: 6.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 287 FICYALFGL-FATLGFFAPslyiiPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTAS 365
Cdd:COG2271    16 FLAYFLNYLdRSNLSVAAP-----PLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLA--IGLLLWGLA 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907079533 366 LFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQ 439
Cdd:COG2271    89 TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAE--WFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 291-462 1.11e-09

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 60.26  E-value: 1.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 291 ALFGLFATlGFFAPSLY-IIPL-GISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPiRKIYIELICVILLTASLFA 368
Cdd:cd17477   193 ALLGAFVA-GFLEGAFYsLLPLyGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFD-RRRVLLGCALLGALAALLL 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 369 FTFATEFWGLMLCSVFFGSMVG---TIGGTHIpmlaeDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKiySR 445
Cdd:cd17477   271 PLVPGLPLALLVLLFLWGGAAGplyTLALALA-----GDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFG--PH 343

                         170
                  ....*....|....*..
gi 1907079533 446 AFYSCAAGMCLAAVCLA 462
Cdd:cd17477   344 GLFLFLAAVALLFLLFL 360
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
279-464 1.50e-09

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 59.87  E-value: 1.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 279 FSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYI--E 355
Cdd:COG0738   204 KSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDvLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRlsA 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 356 LICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTI---GGTHIPMLAeddvvgiekmSSAAGVYVFIQSISGLAGPPL 432
Cdd:COG0738   284 LLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIfslALDGLGKRT----------AAAVSAVLIMGIVGGAIGPPL 353

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1907079533 433 AGLLVDQskiysrafYSCAAGMCLAAVCLALV 464
Cdd:COG0738   354 IGFLADA--------FGLRAAFLVPLVCYLLI 377
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 252-464 5.69e-09

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 57.97  E-value: 5.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 252 EQETRAEQQQTLVTAPKHSQMKAPLLDFSVLkekSFICYalFGLFATLGFFApslyiIPLGISLGIDPDRAAFLLSTMAI 331
Cdd:cd17474   176 PKEKAKSSSATKLRDLKKALRGRGLLTFLVS---AFLYF--FLYFAFLTYLP-----FLLELLYGISPIIIGLLFAGWSV 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 332 AEVFGRIGAGFVLNREpIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKM 411
Cdd:cd17474   246 LLALGSLFVGRLLKKR-FGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTE--LAPEEER 322

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907079533 412 SSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSrAFYSCAAGMCLAAVCLALV 464
Cdd:cd17474   323 GTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSA-PFLVGAAIALAAAVLLALL 374
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 264-464 4.36e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 55.29  E-value: 4.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 264 VTAPKHSQMKAPLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDpdRAAFLLSTMAIAEVFGRIGAGFV 343
Cdd:cd17489   173 PPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKL 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 344 LNRepIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIggthIPMLAED--DVVGIEKMSSAAGVYVFI 421
Cdd:cd17489   251 SDR--KGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLL----FPALQALavDLVPPHRRGAANGTFFIF 324

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1907079533 422 QSISGLAGPPLAGLLVDQSKiYSRAFYSCAagmCLAAVCLALV 464
Cdd:cd17489   325 FDLGIGLGGLLLGLVAELFG-YRAMFLLAA---VVVLLALVLY 363
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
290-466 4.87e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 55.25  E-value: 4.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 290 YALFGLFATLGFFAPSL--YIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTASLF 367
Cdd:COG0738    11 IAIYLLFFLWGFATALWgpLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLL--LGLLLMALGLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 368 AFTFATEFWGLMLCSVFFGSMVG---TIGGTHIPMLAEDDvvGIEKMSSAAGVYvfiqSISGLAGPPLAGLLVDQSKIYS 444
Cdd:COG0738    89 LFALAPSYPLLLLALFLLGLGLGlldVAANPYVAALGPET--AASRLNLLHAFF----SLGALLGPLLGGLLILLGLSLS 162

                         170       180
                  ....*....|....*....|...
gi 1907079533 445 -RAFYSCAAGMCLAAVCLALVRP 466
Cdd:COG0738   163 wHLPYLILAVLLLLLALLFLRSK 185
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 260-464 9.39e-08

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 54.34  E-value: 9.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 260 QQTLVTAPKHSQMKAPLLDFSVLKEKSF-ICYALFGLFATlGFFAPSLYIIPLGISLGID-PDRAAFLLSTMAIAEVFGR 337
Cdd:cd17314   181 EPPDNQARLHVQKKKTQTMGEIFRDKVFwILFIAIFLVLI-GGFLFIANMASLVRSLQLDaPSFVTKLMSIYGLFNAFGR 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 338 IGAGFVLNREpIRKIYIELICVILLTASLFAFTFATEF--WGLMLCSVFFGSMVGtiGGTHIPMLAEDDVVGIEKMSSAA 415
Cdd:cd17314   260 LLWGIVADFF-GGRLSTLSILLTILGLGLCAFLFLLKMtpVGLVLTGSLLGFSYG--GLFTVYPATVSTVFGTESFATLY 336

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1907079533 416 GVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALV 464
Cdd:cd17314   337 GILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILLAV 385
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 293-464 1.06e-07

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 53.73  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 293 FGLFATLGFFapsLYIIPLGI--SLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNR-EPIRKIYIELICVILLTASLFAF 369
Cdd:cd17319   189 FGINYALYGL---LTWLPTYLkqARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRlLRGARRLVIIIGLLLAAVGLLLA 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 370 TFATEFWG--LMLCSVFFGSMVGTIGGTHIPMlaedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAF 447
Cdd:cd17319   266 YLTTSPVVavILLSLAGFGIGAASPVFWSLPA----DLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAF 341

                         170
                  ....*....|....*..
gi 1907079533 448 YSCAAGMCLAAVCLALV 464
Cdd:cd17319   342 LFLAAVALLAALLVLLL 358
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 274-439 1.33e-07

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 53.73  E-value: 1.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 274 APLLDFSVLKEKSFICYALFGLFATLGFFApSLYIIP--LGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRK 351
Cdd:cd17503   167 APLLDLRLFKDRNFTLGLLLSFLLGLGLFG-AMFLLPlyLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRL 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 352 IYIelICVILLTASLFAFTFATE---FWGLMLCSVFFGSMVG-------TIGGTHIPMlaeddvvgiEKMSSAAGVYVFI 421
Cdd:cd17503   246 LLL--AGLLLLALGTLLLAFLTPdtsLWLIILPLFIRGLGMGlvfmplnTLALNSLPP---------EQIGDATALFNTI 314

                         170
                  ....*....|....*...
gi 1907079533 422 QSISGLAGPPLAGLLVDQ 439
Cdd:cd17503   315 RQLGGSIGTALLATLLTN 332
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 280-465 2.34e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 53.00  E-value: 2.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 280 SVLKEKSFICYALFGLFATLGFFAPSLYI-IPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelIC 358
Cdd:cd17329   195 IVLRDRAFLLFLLASFLISLIYFQLESTLpVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILM--IG 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 359 VILLTASLFAFTFATEFWGLMLCSVFF--GSMvgtIGGTHIPMLAeDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLL 436
Cdd:cd17329   273 ILLFAIGFAVLAFANTLAVLILAMIVLtlGEM---LVFPAVQTLV-AALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLL 348

                         170       180
                  ....*....|....*....|....*....
gi 1907079533 437 VDQSkIYSRAFYSCAAGMCLAAVCLALVR 465
Cdd:cd17329   349 LDLL-GPGLPWLILAALGLIAAALLLGLQ 376
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 292-466 2.92e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 52.55  E-value: 2.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 292 LFGLFATLGFFAPSLYII-----PLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYieLICVILLTASL 366
Cdd:cd17324     1 LLALALAAFAIGTTEYVIqgllpDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLL--LVLLLLFILGN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 367 FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKiYSRA 446
Cdd:cd17324    79 LLAALAPSFALLLLARALAGLAHGGFWAIAAAYAA--DLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAA 155

                         170       180
                  ....*....|....*....|
gi 1907079533 447 FYSCAAGMCLAAVCLALVRP 466
Cdd:cd17324   156 FLAIAVLALLAALLLWRLLP 175
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 267-464 3.40e-07

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 52.32  E-value: 3.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 267 PKHSQMKAPLLDFSVLKEKSFICYALF-----GLFATLGFFAPSLYIIPLGISLGIdpdrAAFLLSTMAIAEVFGRIGAG 341
Cdd:cd17333   181 PQQSVGAFSASASRLLRNPSIILGALAlflyvGAETAFSSWVPSYLVEKKHVSDGL----AGYLLSGFWVGITIGRLLGG 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 342 FVLNREPIRKiYIELICV---ILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEDDVVGIekmssaaGVY 418
Cdd:cd17333   257 PISRRIKPHT-LLVLSGSgalLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGT-------SVL 328

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1907079533 419 VFIQSISGLAGPPLAGLLVDQSKIYsRAFYsCAAGMCLAAVCLALV 464
Cdd:cd17333   329 LAAGSIGGAIIPFIMGFIAEAVGIQ-TAML-LITILYAIIFVLALL 372
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 292-461 4.68e-07

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 51.78  E-value: 4.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 292 LFGLFATLGFFAPSLYII--PLGIS--LGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKiyieLICVILLTASLF 367
Cdd:cd17471   203 LLFAAFTLLFAANSMYIIamPLYVTneLGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRR----LLLAGFLAGVLF 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 368 --AFTFATEFWGLMLCSVFFGSMVGTIGGthIPMLAEDDVVGiEKMSSAAGVYVFIQSISGLAGPPLAGLLVdQSKIYSR 445
Cdd:cd17471   279 ylGLALATSLWQLIALQLLNAIFIGITAG--LGISYFQDLMP-GQPGLATTLYSNASRIGSLLGGLLAGVIA-QYFGYRA 354

                         170
                  ....*....|....*.
gi 1907079533 446 AFYSCAAGMCLAAVCL 461
Cdd:cd17471   355 VFLVCAVLALLALVLL 370
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 288-468 5.49e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 51.83  E-value: 5.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 288 ICYALFGLFATLGFFAP--SLYIIPLGISLGIdpdrAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYieLICVILLTAS 365
Cdd:cd17489     1 ILLANFFFFLSFYLLLPvlPLYAHDLGGSEAV----AGLVVGLFTLAALLARPFAGRLLDRFGRKRLL--LIGLLIFALA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 366 LFAFTFATEFWGLMLCSVFFG---SMVGTIGGTHIpmlaeDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSkI 442
Cdd:cd17489    75 TLLYLLATSVALLLVLRLIHGigwGAFTTAAATLV-----ADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL-G 148

                         170       180
                  ....*....|....*....|....*.
gi 1907079533 443 YSRAFYSCAAgmcLAAVCLALVRPCK 468
Cdd:cd17489   149 FAVLFIVAAV---LALLALLLVFLVK 171
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 279-440 1.28e-06

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 50.65  E-value: 1.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 279 FSVLKEKSFICYALFGLFATLGFF-----APSLYIIPLGISlgidPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIY 353
Cdd:cd17320   195 KRVLKNRRFLGYALALGLSFAGLFaylaaAPFIYIEQLGLS----PAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLL 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 354 IE---LICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGG--THIPMLAEDDVVGiekmsSAAGVYVFIQSISGLA 428
Cdd:cd17320   271 RLgllLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPnaTSLALEPFPHVAG-----TASALLGFLQFLIGAL 345

                         170
                  ....*....|..
gi 1907079533 429 GPPLAGLLVDQS 440
Cdd:cd17320   346 AGALVGLLPNGT 357
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 294-459 1.47e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 50.31  E-value: 1.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 294 GLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTASLFAFTFAT 373
Cdd:cd06173   218 ALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLL--IGALLLGLALLVLGLSP 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 374 EFWGLMLCSVFFGSMVGTIG---GTHIPMLAEDDVVGiekmsSAAGVYVFIQSISGLAGPPLAGLLVDQSKIySRAFYSC 450
Cdd:cd06173   296 SLWLLLAALFLLGLAGGLFNvplNTLLQLRVPDELRG-----RVFSVYNALNSGAMPLGALLAGLLADALGL-SAVFLLA 369


                  ....*....
gi 1907079533 451 AAGMCLAAV 459
Cdd:cd06173   370 GALLLLAAL 378
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 286-467 1.80e-06

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 49.92  E-value: 1.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 286 SFICYALFGLFATLGFFAPSLYIIPLGISL---------------------GIDPDRAAFLLSTMAIAEVFGRIGAGFVL 344
Cdd:cd17390   153 ALLCSAIFILNAGLVWFLLSKLWDLLLVRFlmgfsvllfrsnfslyleerfDLSPKTIGYLISYSGVLGALSGFLVGRIL 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 345 NREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFgSMVGTIGGTHIPMLaEDDVVGIEKMSSAAGVYVFIQSI 424
Cdd:cd17390   233 KLYKNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPL-SISSAVLRTCSTSL-LLSRGKSKERGTLLGVGQSVTSL 310

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1907079533 425 SGLAGPPLAGLLVDQSKIYSRAFyscAAGMCLAAVCLALVRPC 467
Cdd:cd17390   311 ARILAPLLSGLLQEFSVSGPGLL---GAVLALAAILLMLARQR 350
MFS_MCT8_10 cd17420
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ...
 108-464 1.84e-06

Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340978 [Multi-domain]  Cd Length: 400  Bit Score: 50.22  E-value: 1.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 108 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSF-----DESNSKISWIISICVFVLTF--TAITALKEHIGWRYS----- 175
Cdd:cd17420     1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLtklgdPEASFKAAWVGALAMGMIFFcsPIVSCFTDKIGCRLTafaga 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 176 -LLFVGLLQLN--------------IMVCGALLR---PIIIQG---------------PGQSPKAVTLEPRREV---QYM 219
Cdd:cd17420    81 aVSFGGLLLSSfcssigalyftygiMFGCGCSFAyqpSLVILGhyfkrrlglvngfvtAGSSVFTVILPPLLRKlldSYG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 220 LENEKTRTSIDS-IDSGVELTTSPKNVPSEAKMEQETRAEQQQTLVTAPKHsqmkapLLDFSVLKEKSFICYALFGLFAT 298
Cdd:cd17420   161 LEGTLRVLSLFMfVLILCSFTYRPLHPSPEDPKSKPGRRTLHSRINLFLRK------IFNVEIFKRKRYVIWALGIPLAL 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 299 LGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREP-IRKIYIELICVILLTASLFAFTFATEFWG 377
Cdd:cd17420   235 FGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPPgVKKMYLQVLSFVSIGLMSMMIPLCNSFGI 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 378 LMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLA 457
Cdd:cd17420   315 LISVCLVMGLFDGCFISIMAPIAFE--LVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIG 392


                  ....*..
gi 1907079533 458 AVCLALV 464
Cdd:cd17420   393 SSLLFFI 399
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 265-464 3.30e-06

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 49.53  E-value: 3.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 265 TAPKHSQMKAPLLDFSV---LKEKSFIC-YALFGLFATLGFFAPSlYIIPLGISL-GIDPDRAAFLLSTMAIAEVFGRIG 339
Cdd:cd17353   190 VDPLANNAENSPRDYTPremLRTPTFWLlWLMFFLNATAGLMLIG-QAKPIGQEFaGLDAGIAALAVSILSIFNGGGRPF 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 340 AGFVLNREPIRKIYIeLICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGiEKMSSAAGVYV 419
Cdd:cd17353   269 WGWLSDKIGRKNTLS-IAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTA--DFFG-TKNAGTNYGLL 344

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1907079533 420 FI-QSISGLAGPPLAGlLVDQSKIYSRAFYSCAAGMCLAAVCLALV 464
Cdd:cd17353   345 YTaKGVGGLIGPIIAA-YVLYTGGYNAAFIIAAALSLVALALALLL 389
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 285-463 3.32e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 49.14  E-value: 3.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 285 KSFICYALFGLFATLGFFAPSLYIiP--LGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIELICVILL 362
Cdd:cd17316   177 RRTLLLILLWFFISFGYYGLTTFL-PtyLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 363 TASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEDDVVGIEkmSSAAGVYVFIQSISGLAGPPLAGLLVDQSKI 442
Cdd:cd17316   256 LALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVR--ATGVGLSYNLGRLGGGGAPPLIALLLASTGG 333

                         170       180
                  ....*....|....*....|.
gi 1907079533 443 YSRAFYScAAGMCLAAVCLAL 463
Cdd:cd17316   334 TGVPALI-LALLAIVALIVAL 353
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 274-466 3.78e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 49.11  E-value: 3.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 274 APLLDFSVLKEKSFICYALFGLFATLGFFA-----PSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREP 348
Cdd:cd17504   166 VPLIDLRLLRRRNVLLANITALLAGFGMFMvfqllPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVG 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 349 IRKIYIeLICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLA 428
Cdd:cd17504   246 PRRVLL-IGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVE--SVPPDRTGIATGMNTVLRTIGSAI 322

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907079533 429 GPPLAGLLVDQSKI------------YSRAFYSCAAgMCLAAVCLALVRP 466
Cdd:cd17504   323 GPAIAGAILTTYTVsitsggvptegaYVLAFLIGAA-LALAALLLSLLIP 371
MFS_MCT8 cd17465
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ...
 277-448 7.02e-06

Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341023 [Multi-domain]  Cd Length: 367  Bit Score: 48.25  E-value: 7.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 277 LDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREP-IRKIYIE 355
Cdd:cd17465   180 LTYKVFRRKTYRIWAFGIATAVLGYFVPYVHLMKYVEEEFKENKREWVLLVCIGASSGIGRLMSGKIGDLIPgLKKIYLQ 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 356 LICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGL 435
Cdd:cd17465   260 VASFLLLGIMSMMIPLCQVFEGVIVVCLFLGLCDGCFITIMAPIAFE--LVGPMQASQAIGYLLGLMAIPMTAGPPIAGL 337

                         170
                  ....*....|...
gi 1907079533 436 LVDQSKIYSRAFY 448
Cdd:cd17465   338 LHDYFGSYHVAFY 350
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 286-465 1.63e-05

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 46.79  E-value: 1.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 286 SFICYALFGLFATLGFFAPSLYIiPL---GIsLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRK--IYIELICVI 360
Cdd:cd17502   168 TILLSSIFGFLFGGALFGLIYYL-PLyfqLV-LGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKplIVIGTILMS 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 361 LLTASLFAFTFATEFWGLMLCSVFFGSMVGTigGTHIPMLAEDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAgllvdqs 440
Cdd:cd17502   246 VGAGLLTTLTLDTSKWLLIGYLILLGLGLGI--GFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAIT------- 316

                         170       180
                  ....*....|....*....|....*
gi 1907079533 441 kiysRAFYSCAAGMCLAAVCLALVR 465
Cdd:cd17502   317 ----DVFLVALALAALAFLLSLFLP 337
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 264-465 1.88e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 46.80  E-value: 1.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 264 VTAPKHSQMKAPLLDFSVLkeksFICYALFglfatLGFFApsLYIIPLGISL------GIDPDRAAFLLSTMAIAEVFGR 337
Cdd:cd17473   182 SAASPGAATAAALPWKRVL----PIYFLAF-----LAMLL--FYVIPIQLPFllqergGGSAALIGLALAIASLAGAIGA 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 338 IGAGFVLNRepIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGV 417
Cdd:cd17473   251 LLFGRLKRR--LGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMS--LVPPELRGRAMGI 326

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1907079533 418 YVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 465
Cdd:cd17473   327 VTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 287-490 2.07e-05

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 46.77  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 287 FICYALFGLfaTLGFFAP--SLYIIPlgiSLGIDPDRAAFLLSTMAIAEV-----FGRIGagfvlNREPIRKIYIeLICV 359
Cdd:cd17471     2 LLATLLTGL--AGAFVLPylSLFLTE---ELGASPLQIGIFMTLSALSGIvvsqwLGRLS-----DRGGDRKPLI-LLAL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 360 ILLTASLFAFTFATEFWGLMLCSVFFGSmvgtIGGTHIPML------------AEDDVVGIEKMSSAAgvyvfiqSISGL 427
Cdd:cd17471    71 LAGALGYLLFAFLRNYWVLLLVGVVLLS----LGAAAFPQLfalareyadrssGRDATLFNSVLRAAF-------SLAWV 139

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907079533 428 AGPPLAGLLVDQSKiYSRAFYSCAAGMCLAAVCLALVRPCKKGLCQNSHSGENQTDRQRGKAL 490
Cdd:cd17471   140 IGPPLAFLLLDVLG-FTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRL 201
MFS_MCT10 cd17464
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ...
 276-448 3.58e-05

Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341022 [Multi-domain]  Cd Length: 395  Bit Score: 45.94  E-value: 3.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 276 LLDFSVLKEKSFICYAlFGLFATL-GFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREP-IRKIY 353
Cdd:cd17464   207 IFNFNIWKSTGYRIWA-FGIPAALfGYFVPYVHLMNHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVADYIPgVKKVY 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 354 IELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLAGPPLA 433
Cdd:cd17464   286 LQVSSFFFIGLMSMMIPLCHVFGGLIAVCLFMGLFDGCFISIMAPIAFE--LVGAQNVSQAIGFLLGLMSIPMTVGPPIA 363

                         170
                  ....*....|....*
gi 1907079533 434 GLLVDQSKIYSRAFY 448
Cdd:cd17464   364 GFLRDRLGSYDVAFY 378
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 287-464 4.16e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 45.65  E-value: 4.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 287 FICYALFGLFATLGFFAPSlyiiplgiSLGIDPDRAAFLLSTMAIAEVFGRIG-AGFVLNREPIRKIYIelICVILLTAS 365
Cdd:cd17330   185 LIALAFAGLESVFSLFLKD--------RFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLR--LGLLLAIIG 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 366 LFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLvdQSKIYSR 445
Cdd:cd17330   255 LLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSK--SVPSKEQGKAQGIIQSLQSLARIIGPLLAGPL--YSFLGPG 330

                         170
                  ....*....|....*....
gi 1907079533 446 AFYSCAAGMCLAAVCLALV 464
Cdd:cd17330   331 VPFLLAAGLLLIALFLLSL 349
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 291-466 4.22e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 45.63  E-value: 4.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 291 ALFGLFATLGFFAPSLYIIPLGIS--LGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTASLFA 368
Cdd:cd17321   173 AVLAAFLLGAALGGLLFLLPLYLQgvLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV--AGLLLTAVGLLL 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 369 FTFATE-------FWGLMLCSVFFGSMVGTIGGThipMLAeddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLV---- 437
Cdd:cd17321   251 LALLGAdssvwllLPGLVLLGLGLGLFATPLTNA---ALS---SVPKEKAGAASGILNTARQLGGALGVALLGALLtagl 324

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1907079533 438 --------------DQSKIYSRAF---YSCAAGMCLAAVCLALVRP 466
Cdd:cd17321   325 sanlgdsgvaallsAAAAAFAAGFhlaFLVAAALALLAALLALLLP 370
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 290-466 6.70e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 45.30  E-value: 6.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 290 YALFGLFATLGFFAPSLYIIPLGISLgIDPDRAAFLLSTMAIAEVFGRIG----AGFVLNREPIRKIYI---ELICVILL 362
Cdd:cd06173     1 FRLLWLAQLLSALGDWIFTVALPWLV-LQLTGSALLVGLVLAAFFLPFLLfspfAGVLADRFDRRRLLIladLLRALLAA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 363 TASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKI 442
Cdd:cd06173    80 VLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPE--LVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGP 157

                         170       180
                  ....*....|....*....|....
gi 1907079533 443 YSrAFYSCAAGMCLAAVCLALVRP 466
Cdd:cd06173   158 GG-AFAINALSFLLSALLLLFIRR 180
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 293-466 7.09e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 44.91  E-value: 7.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 293 FGLFATLGFFApsLYII-PLGISLGIdpdrAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYieLICVILLTASLFAFTF 371
Cdd:cd17329    13 LGFFMVWPFMA--IYLHqQLGLSASI----VGLVLALSAVAGIVASLIGGRLADRFGRKPVM--LAGLLLRALGFALLGF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 372 ATEFWGLMLCSV---FFGSMVGTIGGThipMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSkiYSRAFY 448
Cdd:cd17329    85 AHSPWLFAIALVltgFGGGLFEPASEA---MIA--DVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS--FRLLFL 157

                         170
                  ....*....|....*...
gi 1907079533 449 SCAAGMCLAAVCLALVRP 466
Cdd:cd17329   158 AAAVLFLLAALVLLFLLP 175
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 293-474 7.68e-05

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 44.88  E-value: 7.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 293 FGLFATLGFFAP--SLYiiplGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIyIELICVILLTASLFAFT 370
Cdd:cd17335     7 FFFFAALGSLLPflSVY----LKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKA-LLLLSLLAAVLFFLSLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 371 F-ATEFWGLML----CSVFFGSMVGTIGGTHIPMLAED-DVVGIEKMSSAAGvyvFIqsisglAGPPLAGLLVDQSKI-- 442
Cdd:cd17335    82 FvAQIFWLLLLlvilGAFFSAPVVPLVDSITLQYLGEErERYGKQRLWGSIG---FG------IAALLVGILIDRSSTyk 152

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1907079533 443 -YSRAFYSCAAGMCLAAVCLALVRPCKKGLCQN 474
Cdd:cd17335   153 nYTIAFYVFAVLMLLALLLALKFPFRPKHPEPN 185
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 285-459 1.12e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 44.46  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 285 KSFICYALFGLFATLGFFAPSLYIIPLGiSLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTA 364
Cdd:cd17370   200 KAFWLYLLAVALFALGNFSFAFLILRAQ-ELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLI--LGYLSLAL 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 365 SLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKiYS 444
Cdd:cd17370   277 AYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVA--DLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLIS-PS 353

                         170
                  ....*....|....*
gi 1907079533 445 RAFYSCAAGMCLAAV 459
Cdd:cd17370   354 AAFLFSAVLALIALL 368
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 264-436 2.03e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 43.75  E-value: 2.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 264 VTAPKHSQMKAPLLD--FSVLKEKSFICYALFGLFATLGFFAP-SLYIIPLGISLGIDPDrAAFLLSTMAIAEVFGRIGA 340
Cdd:cd17332   198 VVPPEEEKSKLPLLKslKALLKNRPFLILLLAYLLYFLAFNIVnTVLVYYFKYVLGGRAE-LVLLLLLILSGALLALLPW 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 341 GFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSS------- 413
Cdd:cd17332   277 PPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLA--DVIDYGELKTgkrregi 354

                         170       180
                  ....*....|....*....|...
gi 1907079533 414 AAGVYVFIQSISGLAGPPLAGLL 436
Cdd:cd17332   355 FYSVMTFFRKLGLALAGALVGLI 377
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 281-463 2.04e-04

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 43.76  E-value: 2.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 281 VLKEKSFICYAL---FGLFAT--LGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNRepIRKIYIE 355
Cdd:cd17328   203 LAKNPSFILSTLgftAVSFVTgaLAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADR--LRRKTPR 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 356 ---LICVILLTASLFAFTFATEF--------WGLMLCSVFFGSMvgtiggTHIPMLAEDDVVGIEKM-SSAAGVYVFIQS 423
Cdd:cd17328   281 adpLVCAVGLLAAAPFLFLALVLalsnlllaWVLLFLGEFLLSL------NWAPVFAILLYVVIPTRrSTASAIQILLSH 354

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1907079533 424 ISGLAGPPLAG-----LLVDQSKIYSRAFYSCAAGMCLAAVCLAL 463
Cdd:cd17328   355 LLGDAGSPYLIglisdLLRQNKDSPLAEAASLQYALLLCSFVLVL 399
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 314-464 1.52e-03

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 40.72  E-value: 1.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 314 SLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNRE-PIRKIYIELICVILLTASLFAFTFateFWGLMLCSVFFGSMVG-T 391
Cdd:cd17312   213 VKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfGGRRAPIAVIYMLLMTLSLALFWF---FPHNKLLSIVLLFLIGfF 289

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907079533 392 IGGTH--IPMLAEDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKiYSRAFYSCaAGMCLAAVCLALV 464
Cdd:cd17312   290 VGGPInlIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYG-WSTVFYFL-ISAALLSVLLLLS 362
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 287-464 5.26e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 39.23  E-value: 5.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 287 FICYALFGLfaTLGFFAPSLYIIPLGISLGIDpdRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIELICVILLTASL 366
Cdd:cd17333     2 YISFFSNGL--TDALLGILGPSLEEAFNLNVA--DVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 367 FAFTfaTEFWGLMLCSVFFG-------SMVGTIGGTHIPmlaeddvvgiEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQ 439
Cdd:cd17333    78 IFAT--PSIYLFVVLMFLAGlgagildTGANTFVGALFE----------ESSATRLNVLHGFFGLGALIGPLIATSLLTS 145

                         170       180
                  ....*....|....*....|....*
gi 1907079533 440 SKIYSRAFyscaagMCLAAVCLALV 464
Cdd:cd17333   146 ELSWSWAY------LIIGLIYLLLA 164
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 246-436 7.36e-03

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 38.78  E-value: 7.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 246 PSEAKMEQETRAEQQQTLVTapkhsqMKAPLLDFSVLKEKSFICYALFGLfATLGFFAPSLYIIPLGISLGIDPDRAAFL 325
Cdd:cd17357   226 QELEEIKKESEQMGDQKQVS------LMQLLRDPSLRLPLLLVLVVSASQ-QFSGINAIFFYSTFIFENAGFSPQLAEWA 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 326 LSTMAIAEVFGRIGAGFVLNREPIRKIYIE-----LICVILLTASLFAFTFATEF-WGLMLCSVFFGsMVGTIGGTHIPM 399
Cdd:cd17357   299 NLGIGIVNVLSTIVGPFLIEKVGRRPLLLIslsvcAVALLLMSVFLFLSEQNSWMsYGCIVAIFLFI-FFFAIGLGPIPW 377

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1907079533 400 LAEDDVVGIEKMSSAAGVYVFIQS----ISGLAGPPLAGLL 436
Cdd:cd17357   378 FIGAELFPQAPRSAAQSLGSSVNWtsnfIVGMAFPPLQSIG 418
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 272-463 7.39e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 38.76  E-value: 7.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 272 MKAPLLDFSVLKEKSFICYALFGLFATLGFFAPSLY-------IIPLGISL-GIDPDRA----AFLLSTMAIAEVFGRIG 339
Cdd:cd17313   221 VLKSLLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFftdymgeEVYHGTSAaSSHYGAGvrmgAWGLLIFSLAFLIFSLP 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 340 AGFVLNREPIRKIYieLICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEDDVVGIEKMSSAAGVYV 419
Cdd:cd17313   301 IGKLGKKIGRKKVY--LIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRGQGTDTGLLN 378

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1907079533 420 FIQSISGLAGPPLAGLLVDqSKIYSRAFYSCAAGMCLAAVCLAL 463
Cdd:cd17313   379 LAISLAQILVSLLAGPIID-VKGYGTVFPVAAVASFLSLVGALF 421
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 279-464 7.77e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 38.74  E-value: 7.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 279 FSVLKEKSFICYALFGLFATLGFFAPSLYIIPLgISLGIDPDRAAFLLST---MAIAEVFGRIGAGFVLNRepIRKIYIE 355
Cdd:cd17490   188 LSVLKDKKLLFFSLLAILQQMITFSTTFGFTPL-IAKQLGASSFQLGLLSiiyLLPNALASLLSGTLFYKK--LGERNTI 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079533 356 LICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIggthIPMLAEDDVVGI--EKMSSAAGVYVFIQSISGLAGPPLA 433
Cdd:cd17490   265 IIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGIL----FPLLMSLSIEGVpaEQRSTAMGFFQAIYALGMFLGPVLV 340

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1907079533 434 GLLVDqskIYSRAF-YSCAAGMCLAAVCLALV 464
Cdd:cd17490   341 GIISE---AFGLQTgFFVIGVIALLAAILSLA 369
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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