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Conserved domains on  [gi|1907083298|ref|XP_036012912|]
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tetratricopeptide repeat protein 19, mitochondrial isoform X2 [Mus musculus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 12138572)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR_12 pfam13424
Tetratricopeptide repeat;
205-288 7.84e-08

Tetratricopeptide repeat;


:

Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 48.92  E-value: 7.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083298 205 ETANTYLLLGMCLdscarylLFSKQLSQAQRMYEKALQICQEIQGERHPQTIVLMSDLATTLDAQGHFDDAYIYMQRASD 284
Cdd:pfam13424   1 DVATALNNLAAVL-------RRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALA 73


                  ....
gi 1907083298 285 LARE 288
Cdd:pfam13424  74 LAEK 77
 
Name Accession Description Interval E-value
TPR_12 pfam13424
Tetratricopeptide repeat;
205-288 7.84e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 48.92  E-value: 7.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083298 205 ETANTYLLLGMCLdscarylLFSKQLSQAQRMYEKALQICQEIQGERHPQTIVLMSDLATTLDAQGHFDDAYIYMQRASD 284
Cdd:pfam13424   1 DVATALNNLAAVL-------RRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALA 73


                  ....
gi 1907083298 285 LARE 288
Cdd:pfam13424  74 LAEK 77
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 220-305 2.36e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 39.90  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083298 220 CARYLLFSKQLSQAQRMYEKALQICQEIQGERHPQTIVLMSDLATTLDAQGHFDDAY------IYMQRASDLAREiNHPE 293
Cdd:NF040586  398 QVRYLYLRGDYESARDLAERALERWRERLGPDDRQTLRLRFHLANALRSLGRYEEAReldedtLERQRRVLGLGE-DHPH 476

                          90
                  ....*....|..
gi 1907083298 294 LHMVLSNLAAIL 305
Cdd:NF040586  477 TLMTAGGLGADL 488
 
Name Accession Description Interval E-value
TPR_12 pfam13424
Tetratricopeptide repeat;
205-288 7.84e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 48.92  E-value: 7.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083298 205 ETANTYLLLGMCLdscarylLFSKQLSQAQRMYEKALQICQEIQGERHPQTIVLMSDLATTLDAQGHFDDAYIYMQRASD 284
Cdd:pfam13424   1 DVATALNNLAAVL-------RRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALA 73


                  ....
gi 1907083298 285 LARE 288
Cdd:pfam13424  74 LAEK 77
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 220-305 2.36e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 39.90  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083298 220 CARYLLFSKQLSQAQRMYEKALQICQEIQGERHPQTIVLMSDLATTLDAQGHFDDAY------IYMQRASDLAREiNHPE 293
Cdd:NF040586  398 QVRYLYLRGDYESARDLAERALERWRERLGPDDRQTLRLRFHLANALRSLGRYEEAReldedtLERQRRVLGLGE-DHPH 476

                          90
                  ....*....|..
gi 1907083298 294 LHMVLSNLAAIL 305
Cdd:NF040586  477 TLMTAGGLGADL 488
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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