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Conserved domains on  [gi|1907118825|ref|XP_036015920|]
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type 2 lactosamine alpha-2,3-sialyltransferase isoform X3 [Mus musculus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 174-363 5.75e-128

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23984:

Pssm-ID: 480271  Cd Length: 206  Bit Score: 365.61  E-value: 5.75e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 174 PCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSDSSHYDPNTTAVLVVFKPQD 253
Cdd:cd23984     1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 254 LRWLVEILLGKKINTQGFWKTPALKLIYKQYQIRILDPYITSEAAFQMLRFPRVFPKDQKPKHPTTGIIAITMAFHICSE 333
Cdd:cd23984    81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                         170       180       190
                  ....*....|....*....|....*....|
gi 1907118825 334 VHLAGFKYNFYSPNSPLHYYGNATMSLMKQ 363
Cdd:cd23984   161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTK 190
 
Name Accession Description Interval E-value
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 174-363 5.75e-128

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 365.61  E-value: 5.75e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 174 PCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSDSSHYDPNTTAVLVVFKPQD 253
Cdd:cd23984     1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 254 LRWLVEILLGKKINTQGFWKTPALKLIYKQYQIRILDPYITSEAAFQMLRFPRVFPKDQKPKHPTTGIIAITMAFHICSE 333
Cdd:cd23984    81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                         170       180       190
                  ....*....|....*....|....*....|
gi 1907118825 334 VHLAGFKYNFYSPNSPLHYYGNATMSLMKQ 363
Cdd:cd23984   161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTK 190
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 169-365 1.55e-66

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 210.93  E-value: 1.55e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 169 EFDRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSD-------SSHYDPN 241
Cdd:pfam00777  37 PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPF 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 242 TTAVLVVFKPQDLRWLVEILLGKKINT----QGFWKTPALKLiyKQYQIRILDPYITSEAAFQMLRFPRVfpkdqKPKHP 317
Cdd:pfam00777 117 VEFVLVPFKGRDLLWLPAFLTKGNVSRslrvLYTLKEVKIPV--DPDKVLFLHPDFLRYVANFWLRSHGL-----KGRRP 189

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1907118825 318 TTGIIAITMAFHICSEVHLAGFKYNFYSPNSPLHYYGNATMSLMKQAG 365
Cdd:pfam00777 190 STGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYG 237
 
Name Accession Description Interval E-value
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 174-363 5.75e-128

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 365.61  E-value: 5.75e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 174 PCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSDSSHYDPNTTAVLVVFKPQD 253
Cdd:cd23984     1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 254 LRWLVEILLGKKINTQGFWKTPALKLIYKQYQIRILDPYITSEAAFQMLRFPRVFPKDQKPKHPTTGIIAITMAFHICSE 333
Cdd:cd23984    81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                         170       180       190
                  ....*....|....*....|....*....|
gi 1907118825 334 VHLAGFKYNFYSPNSPLHYYGNATMSLMKQ 363
Cdd:cd23984   161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTK 190
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 174-362 2.08e-103

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 303.06  E-value: 2.08e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 174 PCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSDSSHYDPNTTAVLVVFKPQD 253
Cdd:cd23967     1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 254 LRWLVEILLGKKINTQ-GFWKTPALKLIYKQYQIRILDPYITSEAAFQMLRFPrvFPKDQKPKHPTTGIIAITMAFHICS 332
Cdd:cd23967    81 LLWLQAVIKGKKPNGKgGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLP--MNGKQGKNVPTTGIIAIVMALHYCD 158

                         170       180       190
                  ....*....|....*....|....*....|
gi 1907118825 333 EVHLAGFKYNFYSPNSPLHYYGNATMSLMK 362
Cdd:cd23967   159 EVDIAGFGYDPSDPNAPLHYYDSLTMKAIK 188
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 174-365 9.13e-77

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 235.33  E-value: 9.13e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 174 PCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSDSS-HYDPNTTAVLVVFKPQ 252
Cdd:cd23982     1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGiENDPDTLLVLVPFKPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 253 DLRWLVEILLGKKINTQGFWKTPALKLIYKQYQIRILDPYITSEAAFQMLRFPRvfpKDQKPKHPTTGIIAITMAFHICS 332
Cdd:cd23982    81 DFYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPG---QRKKKQKPTTGLLAITLALHLCD 157

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1907118825 333 EVHLAGFKY-NFYSPNSPLHYYGNATMSLMKQAG 365
Cdd:cd23982   158 EVHIAGFGYpDNGNSNQPIHYYNQITLKSMANSG 191
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 169-365 1.55e-66

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 210.93  E-value: 1.55e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 169 EFDRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSD-------SSHYDPN 241
Cdd:pfam00777  37 PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPF 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 242 TTAVLVVFKPQDLRWLVEILLGKKINT----QGFWKTPALKLiyKQYQIRILDPYITSEAAFQMLRFPRVfpkdqKPKHP 317
Cdd:pfam00777 117 VEFVLVPFKGRDLLWLPAFLTKGNVSRslrvLYTLKEVKIPV--DPDKVLFLHPDFLRYVANFWLRSHGL-----KGRRP 189

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1907118825 318 TTGIIAITMAFHICSEVHLAGFKYNFYSPNSPLHYYGNATMSLMKQAG 365
Cdd:pfam00777 190 STGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYG 237
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 175-364 8.10e-64

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 202.46  E-value: 8.10e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 175 CKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSDSSHYDPNTTAVLVVFKPQDL 254
Cdd:cd23981     2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQDF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 255 RWLVEILLGKKIN-TQGFWKTPALKLIYKQYQIRILDPYITSEAAFQMLRFPRVFPKDQKPKHPTTGIIAITMAFHICSE 333
Cdd:cd23981    82 KWLKYIVYKEKVSaSDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCDE 161

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1907118825 334 VHLAGFKYNFYSPNSPLHYYGNATMSLMKQA 364
Cdd:cd23981   162 VAVAGFGYDMNTPNAPLHYYETIKMSAIKES 192
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 174-362 2.98e-63

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 201.12  E-value: 2.98e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 174 PCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSDSSHYDPNTTAVLVVFKPQD 253
Cdd:cd23983     1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 254 LRWLVEILLGKKI---NTQGFWKTPALKLIYKQYQIRILDPYITSEAAFQMLRFP----RVFPKDQkpKHPTTGIIAITM 326
Cdd:cd23983    81 FAWLKAMVKKEPLsfwSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPepqsRLWGWDK--NVPTLGVTAVVL 158

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1907118825 327 AFHICSEVHLAGFKYNFYSPNSPLHYYGNATMSLMK 362
Cdd:cd23983   159 ATHLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMN 194
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 141-356 1.38e-35

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 131.61  E-value: 1.38e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 141 FPLPYGIKTFE-TYFSSALSKLQSCDLFDEF----DRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEE 215
Cdd:cd23964    43 YKLPFGWGGLNrEVVERLLRNLNLTSSRYMFvlrgGRPRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEK 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 216 EVGTRTTFRLFYPESVF-SDSSHY--DPNTTAVLVVFKPQDLRWLVEILLGKKINTQ---GFWKTPALKLIYKQYQIRIL 289
Cdd:cd23964   123 DVGTKTSFYTFFPESLHnSLLKHVpqDKDTKYLFIPFKIRDYDYLDAVLSGKPVPDGcdkGKRPPPLFGPKLNATNVRLL 202

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907118825 290 DPYITSEAAFQMLRFPRVFpkdqkpkHPTTGIIAITMAFHICSEVHLAGFKYNfysPNSPLHYYGNA 356
Cdd:cd23964   203 HPDFIRYLFNRWLNSSTSY-------RPTTGALMLLTALHTCDQVSVYGFGYD---PRFSLHYYDKT 259
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 165-353 1.78e-35

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 130.86  E-value: 1.78e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 165 DLFDEFDRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVfsdsSHYDPNTTA 244
Cdd:cd23966    67 NPYRTRDPNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESA----VDLDPGVHL 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 245 VLVVFKPQDLRWLVEILLGKKInTQGFWKTPAlKLIYKQYQIRILDPyitseaAFqmlrFPRVFPK--DQKPKHPTTGII 322
Cdd:cd23966   143 VLVPFKVLDLQWLISALTTGEI-TRTYTPVKR-FIKADKDKVLVINP------AF----IKYVHDNwtEHHGRYPSTGFL 210

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1907118825 323 AITMAFHICSEVHLAGF---KYNFYSpnsplHYY 353
Cdd:cd23966   211 ALIFALHICDEVSVFGFgadSKGNWH-----HYW 239
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 178-361 2.03e-35

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 128.25  E-value: 2.03e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 178 CVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRL-------FYPESVFSDSSHYDPNTTAVLVVF- 249
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVlnskwagFYLRGPRCGCHPLPLEEEVVLILSr 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 250 -KPQDLRWLVEILLGKKiNTQGFWKTPALKLIykQYQIRILDpyitseaafqmlrFPRVFPkDQKPKHPTTGIIAITMAF 328
Cdd:cd19952    81 aAAADFKRLKRRKKRHD-NAVLLLTDPAPDLL--SYVRKRLE-------------KLGLKS-FFGGNAPSSGLLAVLLAL 143

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1907118825 329 HICSEVHLAGF-KYNFYSPNSPLHYYGNATMSLM 361
Cdd:cd19952   144 QLCDSVDLYGFgVDSGHAPKVPYHYYDLVEAEEG 177
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 165-366 5.71e-28

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 110.74  E-value: 5.71e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 165 DLFDEFDRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVfsdsSHYDPNTTA 244
Cdd:cd23980    71 DPLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESF----RELAQNVSM 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 245 VLVVFKPQDLRWLVEILLGKKINtQGFWKTPAlKLIYKQYQIRILDPyitseaAFQMLRFPRVFpkDQKPKHPTTGIIAI 324
Cdd:cd23980   147 ILVPFKTLDLEWVISATTTGTIS-HTYVPVPR-KIKVKKEKILIYHP------AFIKYVFDRWL--QGHGRYPSTGILSV 216

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1907118825 325 TMAFHICSEVHLAGFKYNfySPNSPLHYY-GNATMSLMKQAGL 366
Cdd:cd23980   217 IFSLHVCDEVDLYGFGAD--SKGNWHHYWeNNPSAGAFRKTGV 257
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 175-354 1.43e-26

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 105.40  E-value: 1.43e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 175 CKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLF-YP--ESVFSDSSHYDPNTTA-VLVVFk 250
Cdd:cd23965     1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVsHSslPRLLRNAILLLAGTRApTVVVF- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 251 pqdlrWLVEIllgkKINTQGFWKTPALKLIYKQYqiRILDPYITSEAafQMLRFPRVFPKDQ-KPKHPT-----TGIIAI 324
Cdd:cd23965    80 -----WGPET----KMNKDGAGKYNLLRSLSKKY--PDVEFYSLTPE--KMDYADELFEKETgKSRIKSgtwlsTGWFTM 146

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1907118825 325 TMAFHICSEVHLAGFKYNFY---SPNS--PLHYYG 354
Cdd:cd23965   147 LLALDVCDEIKVYGMVPENYcreHPNSkvPYHYYE 181
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 159-362 2.26e-23

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 98.10  E-value: 2.26e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 159 SKLQSCDLFDEFDRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESV--FSDSS 236
Cdd:cd23963    47 SLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSILkrRYNSL 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 237 HYDPNTTAVLvvfkpQDLRWLVE-ILLGKKINTQgfWKTPALKLIYKQYQIRILDPYItseaAFQMLRFPRVFPK----D 311
Cdd:cd23963   127 KKNRDRDKFL-----NRLKEYNGsILWYPKFSFK--SSTNLLLKAARALKKNGLNLTV----VYSNPEHFLAVQKfwkrR 195

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907118825 312 QKPKHPTTGIIAITMAFHICSEVHLAGF-KYNFYSPNSPL--HYYGNATMSLMK 362
Cdd:cd23963   196 GLEKRPSTGLYLVSLALTFCDEIHLYGFwPFPTDPNGRPVpyHYYDDLSPSTKN 249
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 167-339 4.90e-23

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 97.25  E-value: 4.90e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 167 FDEFDRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESvfsdSSHYDPNTTAVL 246
Cdd:cd23979    72 YRSWDPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPES----AKNLPANVSFVL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 247 VVFKPQDLRWLVEILLGKKINtqgFWKTPALKLI-YKQYQIRILDPyitseaAFqmlrFPRVFPK--DQKPKHPTTGIIA 323
Cdd:cd23979   148 VPFKTLDLLWITSALSTGQIR---FTYAPVKQFLrVDKDKVQIYNP------AF----FKYIHDRwtEHHGRYPSTGMLV 214

                         170
                  ....*....|....*.
gi 1907118825 324 ITMAFHICSEVHLAGF 339
Cdd:cd23979   215 LFFALHVCDEVNVYGF 230
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 175-353 1.11e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 88.27  E-value: 1.11e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 175 CKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSDSSHY----------DPNTTA 244
Cdd:cd23973    83 CIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILqkrgfknipqDKDIKY 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 245 VLVVFKPQDLRWLVEILLGKKINTQGFWKTPALKLIYKQYQiriLDPYITSEAAFqmLRFPR---VFPKDQKPKH----- 316
Cdd:cd23973   163 ILFPEGPRDYQWLEALLKNKTIPSGAYYGRRPRSYFSGDFT---EDKYLVLHPDF--LRYVKnrfLRSKTLKGKYwaiyr 237

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1907118825 317 PTTGIIAITMAFHICSEVHLAGFKYNFYSpNSPLHYY 353
Cdd:cd23973   238 PTTGAFLLLTALHLCDTVSAYGFITEDYR-KYPDHYY 273
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 176-357 2.53e-18

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 83.47  E-value: 2.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 176 KRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSDSSHYDPNttavlvvfkpqDLR 255
Cdd:cd23968    46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLINSQILSKPEFNFLTD-----------PLY 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 256 WLVEILLGKKINTQG----FWKTPALKLI--YKQYQIR-------ILDPyitseaafqmlRFP--------RVFPKDQKP 314
Cdd:cd23968   115 RNVTLLVWDPSSYNVnlekWYKKPDFDFFpnYIKYRRRhpeepfyLIDP-----------RFLwrlwdilqEYTPEKIKP 183

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1907118825 315 KHPTTGIIAITMAFHICSEVHLagfkYNFYSPN--SPL-HYYGNAT 357
Cdd:cd23968   184 NPPSSGFIGIVLMLHLCDWVDV----YEYVPSVrqTDRcHYYDVEK 225
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 174-339 7.19e-16

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 76.67  E-value: 7.19e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 174 PCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLF------YPESVFSDSSHYdpnTTAVLV 247
Cdd:cd23985    44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLInsqlvtTEKHKFLKDSLY---NEGILI 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 248 VFKPQDLrwlveillgkKINTQGFWKTPALKLI--YKQYqiRILDPyitsEAAFQMLRfPRV-----------FPKDQKP 314
Cdd:cd23985   121 VWDPAPY----------HSDIPEWYKNPDYNFFenYKTY--RRLNP----NQPFYILH-PQMqwelwdiiqenSPEEIQP 183

                         170       180
                  ....*....|....*....|....*
gi 1907118825 315 KHPTTGIIAITMAFHICSEVHLAGF 339
Cdd:cd23985   184 NPPSSGMLGIILMMTLCDQVDVYEF 208
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 156-366 1.77e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 76.33  E-value: 1.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 156 SALSKLQSCD---LFDEFDR----VPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYP 228
Cdd:cd23974    58 DALNLLNSSAngqMFDWWDRpngrSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFST 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 229 ESVFSDSSHYD-------PNTTAVLVVFKPQDLR--WLVEILLGKKINTQGFWKTPALKLIY----KQYQIRILDPYITS 295
Cdd:cd23974   138 NTLMNSLRAYAgvgfngpPQSKETRYIFLPDHDRdyLLVKAALTHTPIDRGRDKSKRPSKYFgkdvTAEKFKIYHPDFIR 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 296 EAAFQMLRFPRVFPKDQKPKHPTTGIIAITMAFHICSEVHLAGF---KYNFYSPN------SPLHYYGNATMSL-MK--- 362
Cdd:cd23974   218 YLRNRFLWSPILNTKQRDIYRPSTGAVMLLAALHTCDQVSAYGFmtpDYGKYSDHyydktyHKVVFYANHDLRLeMQlwq 297


                  ....*..
gi 1907118825 363 ---QAGL 366
Cdd:cd23974   298 klhKAGL 304
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 176-359 2.10e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 75.53  E-value: 2.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 176 KRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPeSVFSDSSHYDPNTTavlvvfkpqDLR 255
Cdd:cd23969    65 RTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNP-SVIPHAYGDLVNAT---------DKE 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 256 WLVEILlgKKINTQGFWkTPALKLIYKQYQIRILDPYI--------TSEAAFQMLRFPRVFPKDQK--PKHPTTGIIAIT 325
Cdd:cd23969   135 KFVERL--RQLGDSILW-IPAFVSKGGEEHVQWTNEIIlkhklnvkTAYPPLRLNHAIRGYWLTTKfrIKRPSTGLLMYT 211

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1907118825 326 MAFHICSEVHLAGFkYNF----YSPNSPLHYYGNATMS 359
Cdd:cd23969   212 LATRFCDEIHLYGF-YPFsedgNGRAVKYHYYDNRKYL 248
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 109-360 7.49e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 74.47  E-value: 7.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 109 PAFANLLRFPqlYPFLCRADFIKVAAMSGTNNFPLPYGIKTF-ETYFSSALSKL---QSCDLFDEFDRVP-CKRCVVVGN 183
Cdd:cd23972    13 PHFRGLFNFD--IPVLLWGQHFTPALWDRLSQRKVPYGWKGLsHQVVASTLSLLndsANAKLFFPRDTPGkCIRCAVVGN 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 184 GGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLF----YPESVFSDSSH---YDPNTTAVLVVFKPQDLRW 256
Cdd:cd23972    91 GGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYGFtvntMKNSLISYWNLgftRTPQGQDLQYIFIPSDIRD 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 257 LVEI---LLGKKIN---------TQGFWKTPA---LKLIYKQYQIRILDPYITSEaaFQMLRFPRVFpkdqkpkHPTTGI 321
Cdd:cd23972   171 YVMLrsaILGVPVPegldkgdrpHKYFGPEASakkFKLLHPDFISYLTDRFLKSK--LLNTHYGHLY-------MPSTGA 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1907118825 322 IAITMAFHICSEVHLAGF---KYNFYSPN------SPLHYYGNATMSL 360
Cdd:cd23972   242 LMLLTALHTCDQVSAYGFitsNYWKFSDHyyerkkKPLVFYANHDMLL 289
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 176-353 1.05e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 73.58  E-value: 1.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 176 KRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPesvfSDSSHYDPNttavlvVFKPQDLR 255
Cdd:cd23970    69 NTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNP----SILEKYYNN------LLTIQDRN 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 256 WLVEIL--LGKKIntqgFWkTPALKLIYKQYQIRILDPYItseaaFQMLRFPRV---FP-------------KDQKPKHP 317
Cdd:cd23970   139 NFFLSLkkLDGAI----LW-IPAFFFHTSATVTRTLVDFF-----VEHRGQLKVqlaWPgnimqhvnrywktKHLSPKRL 208

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1907118825 318 TTGIIAITMAFHICSEVHLAGF-KYNFYSPNSPL--HYY 353
Cdd:cd23970   209 STGILMYTLASAICEEIHLYGFwPFGFDPTGTPLpyHYY 247
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 176-356 1.26e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 73.45  E-value: 1.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 176 KRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPE----------------------SVFS 233
Cdd:cd23988    65 KTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSvvqrafggfrnesdrekfvhrlSMLN 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 234 DSSHYDPnttAVLVVFKPQDLRWLVEILLGKKINTQGFWktPALKLIYKqyqirILDPYITSEAAFqmlrfprvfpkdqk 313
Cdd:cd23988   145 DSVLWIP---AFMVKGGEKHVEWVNALILKNKLKVRTAY--PSLRLIHA-----VRGYWLTNKVNI-------------- 200

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907118825 314 pKHPTTGIIAITMAFHICSEVHLAGF------------KYNFYSpNSPLHYYGNA 356
Cdd:cd23988   201 -KRPSTGLLMYTLATRFCDEIHLYGFwpfpkdangnpvKYHYYD-DLKYRYFSNA 253
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 175-353 7.52e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 69.96  E-value: 7.52e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 175 CKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESV---FSDSSHY--DPNTTaVLVVF 249
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVpllLKNPDYFfkETNET-IYVIW 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 250 KP-----QDLRWLVEILLGKKINtqgfwktpalklIYKQYQIrildpYITSEAafQMLRFPRVFPKD------QKPKHPT 318
Cdd:cd23975    80 GPfrnmrKDGKGIVYNMLKKAVE------------SYPQAKI-----YVTTEK--RMSYCDTVFKKEtgkdrvQSGSYLS 140

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1907118825 319 TGIIAITMAFHICSEVHLAGFKYNFYSPNS-----PLHYY 353
Cdd:cd23975   141 TGWFTLILAMDACYGIHVYGMINDTYCKTEgyrkvPYHYY 180
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 175-353 8.32e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 69.88  E-value: 8.32e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 175 CKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSdsshydpnttavlVVFKPQDL 254
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYR-------------VLRRPQEF 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 255 RWL----VEILLGKKINTQGFWKTPALKLIYKQYQI-RILDPYITSEAafQMLRFPRVFP----KDQKPKHP--TTGIIA 323
Cdd:cd23978    68 LNRtpetTLIFWGPPNKMQKDGKSNLFRIIQRASMTfPNMSAFVVSPR--RMRQFDDLFRgetgRDRKKSHSwlSTGWFT 145

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1907118825 324 ITMAFHICSEVHLAGF-KYNFYSPNS-----PLHYY 353
Cdd:cd23978   146 MVIAVELCDNVHVYGMvPPNYCSKRPtpkkmPYHYY 181
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 176-336 2.56e-13

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 69.48  E-value: 2.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 176 KRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFR------LFYPESVFSDSSHYdpnTTAVLVVF 249
Cdd:cd23986    50 RSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRiinsqiLTNPNHHFIDSSLY---KDVILVAW 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 250 KPQDLrwlveillgkKINTQGFWKTPALKLI--YKQYQIR-------ILDPYITseaaFQMLRFPRVFPKDQ-KPKHPTT 319
Cdd:cd23986   127 DPAPY----------SANLHKWYKKPDYNLFtpYVQYRKRnpnqpfyILHPKFI----WQLWDIIQENTQEKiQPNPPSS 192

                         170
                  ....*....|....*..
gi 1907118825 320 GIIAITMAFHICSEVHL 336
Cdd:cd23986   193 GFIGILIMMSMCREVHV 209
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 176-365 2.61e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 69.58  E-value: 2.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 176 KRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESV---FSD------------------ 234
Cdd:cd23987    65 KTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVqraFEDlvnetwkekflqrlqsln 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 235 -SSHYDPnttAVLVVFKPQDLRWLVEILLGKKINTQGFWktPALKLIYKqyqirILDPYITSEAAFqmlrfprvfpkdqk 313
Cdd:cd23987   145 gSILWIP---AFMAKGGEERVEWVNDLILKHHINVRTAY--PSLRLLHA-----VRGYWLTNKVHI-------------- 200

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907118825 314 pKHPTTGIIAITMAFHICSEVHLAGFKYNFYSPN-SPL--HYYGNATMSLMKQAG 365
Cdd:cd23987   201 -KRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNqNPVkyHYYDSLKYGYTSQAS 254
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 175-353 1.14e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 63.73  E-value: 1.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 175 CKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESV---FSDSSHY-DPNTTAVLVVFK 250
Cdd:cd23977     1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVpllLRNQGYFfQQSRDTKYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 251 PqdLRWLVEILLGKKINTqgfwkTPALKLIYKQYQIRILdpyiTSEaafQMLRFPRVFpKDQKPKHP-------TTGIIA 323
Cdd:cd23977    81 P--ERNMDRDGGGKTYRA-----LLTLAKMYPHLQVYTL----TEE---KMAYCDGVF-QNETGKNRmksgsflSTGWFT 145

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1907118825 324 ITMAFHICSEVHLAGFKYNFY-----SPNSPLHYY 353
Cdd:cd23977   146 MILALELCEEILVYGMVSDSYcrnknHSSVPYHYY 180
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 170-355 9.88e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 58.81  E-value: 9.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 170 FDRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPvLGHEEEVGTRTTF-------------------RLF---- 226
Cdd:cd23971    59 FSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPP-LNDSKDVGSKTNLvtanpsilrekfhnlkkrrRPFverm 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 227 --YPESV-----FSDSSHYDPNTTAVLVV-----------FKPQDLRWLVEillgkkintqgFWKTpalkliykqyqiri 288
Cdd:cd23971   138 kvYGNALlllpaFSYTSNTEPSLRALYTLedfgspqkvlfFNPEYLRNLSR-----------YWKS-------------- 192

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 289 ldpyitseaafQMLRFPRvfpkdqkpkhPTTGIIAITMAFHICSEVHLAGF-KYNFYSPNSPL--HYYGN 355
Cdd:cd23971   193 -----------KGLKARR----------LSTGLMLVSAALELCENVHLYGFwPFSTDLDGNPIshHYYDN 241
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 170-355 2.15e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 54.84  E-value: 2.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 170 FDRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLG-HEEEVGTRTTFRLFYPeSVFSDSSH---------YD 239
Cdd:cd23990    59 YSRSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPISEkYVRDVGVKTDVVTINP-SIITERFHklekwrrpfYE 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 240 -----PNTTAVLVVF---KPQDLRWLVEILLgkkintQGFWKTPALKLIYKQYQIRIldpyitseAAFQMLRFPRVfpkd 311
Cdd:cd23990   138 vlqvyENASVVLPAFyntRNTDVSIRVKYVL------DDFESQQAVYYFHPQYLLNV--------SRFWLRQGVRA---- 199

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907118825 312 qkpKHPTTGIIAITMAFHICSEVHLAGFkYNFysPNSPL------HYYGN 355
Cdd:cd23990   200 ---KRISSGLMLVTAALELCEEVHLYGF-WAF--PMNPSgifithHYYDN 243
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 170-221 5.80e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 53.22  E-value: 5.80e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907118825 170 FDRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHE-EEVGTRT 221
Cdd:cd23991    59 FRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGNIsKDVGSKT 111
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 172-353 3.05e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 51.02  E-value: 3.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 172 RVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVfsdsshydpnttavlvvfkP 251
Cdd:cd23976    12 KMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSI-------------------Q 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118825 252 QDLRWLVEILLGKKINTQGFW------KTPALKLIYKQYQI--RI---LDPYITSEAafQMLRFPRVFP----KDQKPKH 316
Cdd:cd23976    73 RILRNRNELLNVSQGTVFIFWgpsnymRRDGKGLVYNNLQLmnQIlpkLKVYTITRH--KMLQFDELFKretgKDRKISN 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1907118825 317 P--TTGIIAITMAFHICSEVHLAG-----FKYNFYSPNSPLHYY 353
Cdd:cd23976   151 TwlSTGWFTMIIALELCDRINVYGmvppdFCRDPNHPSVPYHYY 194
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 172-221 5.88e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 50.21  E-value: 5.88e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907118825 172 RVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVL-GHEEEVGTRT 221
Cdd:cd23989    60 QLPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLSrEYTDDVGTKT 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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