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Conserved domains on  [gi|1907156467|ref|XP_036020103|]
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zinc finger protein 69 isoform X2 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
12-73 1.58e-29

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 109.60  E-value: 1.58e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907156467   12 LTFKDIAVDLSQEEWGQLAPAYQDLYREVMLENYRNLVSVaGYQLSKPTVISQLEKGEGPCM 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL-GFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
160-391 1.63e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156467 160 NKLENPESSNVILEQKHRKHKPARKRNKYKLDSIDHPVSCmrARRYPCNVCEKMFKQPIHLVEHMRTHTG-EKPFRCKEC 238
Cdd:COG5048   218 QNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA--SESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQC 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156467 239 GRAFSQSASLNTHQR--IHTGE--KPFACEE--CGKAFRHRSSLNQHHRTHTGEKPFTC--DKCQKAFSQNI-----SLV 305
Cdd:COG5048   296 NISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSL 375

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156467 306 QHLRTHSGEKPFSC--SECGKPFRQIRHLSEHVRIHTGEKP--YKCTSCCKTFSHRAYLTHHQRIHTGERPYKCkECGKA 381
Cdd:COG5048   376 QQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKS 454

                         250
                  ....*....|
gi 1907156467 382 FRQRIHLSNH 391
Cdd:COG5048   455 FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
415-440 3.21e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.21e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907156467 415 SFKKHQRHHTGEKPYECTECGKSFSY 440
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
12-73 1.58e-29

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 109.60  E-value: 1.58e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907156467   12 LTFKDIAVDLSQEEWGQLAPAYQDLYREVMLENYRNLVSVaGYQLSKPTVISQLEKGEGPCM 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL-GFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 11-51 5.59e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.82  E-value: 5.59e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907156467  11 SLTFKDIAVDLSQEEWGQLAPAYQDLYREVMLENYRNLVSV 51
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 12-50 4.42e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.20  E-value: 4.42e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907156467  12 LTFKDIAVDLSQEEWGQLAPAYQDLYREVMLENYRNLVS 50
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
160-391 1.63e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156467 160 NKLENPESSNVILEQKHRKHKPARKRNKYKLDSIDHPVSCmrARRYPCNVCEKMFKQPIHLVEHMRTHTG-EKPFRCKEC 238
Cdd:COG5048   218 QNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA--SESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQC 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156467 239 GRAFSQSASLNTHQR--IHTGE--KPFACEE--CGKAFRHRSSLNQHHRTHTGEKPFTC--DKCQKAFSQNI-----SLV 305
Cdd:COG5048   296 NISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSL 375

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156467 306 QHLRTHSGEKPFSC--SECGKPFRQIRHLSEHVRIHTGEKP--YKCTSCCKTFSHRAYLTHHQRIHTGERPYKCkECGKA 381
Cdd:COG5048   376 QQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKS 454

                         250
                  ....*....|
gi 1907156467 382 FRQRIHLSNH 391
Cdd:COG5048   455 FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
219-244 6.11e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.11e-05
                          10        20
                  ....*....|....*....|....*.
gi 1907156467 219 HLVEHMRTHTGEKPFRCKECGRAFSQ 244
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
415-440 3.21e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.21e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907156467 415 SFKKHQRHHTGEKPYECTECGKSFSY 440
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 369-449 6.35e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 6.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156467 369 GERPYKCK--ECGKAFRQRIHLSNHRtVHtgvkayecNRCGKAYRHDSSFKKHQRHHTGEKPYECTECGKSFSYNSSLSR 446
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1907156467 447 HQK 449
Cdd:COG5189   417 HRK 419
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
12-73 1.58e-29

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 109.60  E-value: 1.58e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907156467   12 LTFKDIAVDLSQEEWGQLAPAYQDLYREVMLENYRNLVSVaGYQLSKPTVISQLEKGEGPCM 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL-GFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 11-51 5.59e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.82  E-value: 5.59e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907156467  11 SLTFKDIAVDLSQEEWGQLAPAYQDLYREVMLENYRNLVSV 51
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 12-50 4.42e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.20  E-value: 4.42e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907156467  12 LTFKDIAVDLSQEEWGQLAPAYQDLYREVMLENYRNLVS 50
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
160-391 1.63e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156467 160 NKLENPESSNVILEQKHRKHKPARKRNKYKLDSIDHPVSCmrARRYPCNVCEKMFKQPIHLVEHMRTHTG-EKPFRCKEC 238
Cdd:COG5048   218 QNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA--SESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQC 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156467 239 GRAFSQSASLNTHQR--IHTGE--KPFACEE--CGKAFRHRSSLNQHHRTHTGEKPFTC--DKCQKAFSQNI-----SLV 305
Cdd:COG5048   296 NISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSL 375

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156467 306 QHLRTHSGEKPFSC--SECGKPFRQIRHLSEHVRIHTGEKP--YKCTSCCKTFSHRAYLTHHQRIHTGERPYKCkECGKA 381
Cdd:COG5048   376 QQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKS 454

                         250
                  ....*....|
gi 1907156467 382 FRQRIHLSNH 391
Cdd:COG5048   455 FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
287-447 8.87e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 8.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156467 287 KPFTCDKCQKAFSQNISLVQHLRT--HSGE--KPFSCSE--CGKPFRQIRHLSEHVRIHTGEKPYKC--TSCCKTFS--- 355
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpll 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156467 356 ---HRAYLTHHQRIHTgERPYKC--KECGKAFRQRIHLSNHRTVHTGVKAYECN--RCGKAYRHDSSFKKHQRHHTgEKP 428
Cdd:COG5048   368 nnePPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT-NHA 445

                         170
                  ....*....|....*....
gi 1907156467 429 YECTECGKSFSYNSSLSRH 447
Cdd:COG5048   446 PLLCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
219-244 6.11e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.11e-05
                          10        20
                  ....*....|....*....|....*.
gi 1907156467 219 HLVEHMRTHTGEKPFRCKECGRAFSQ 244
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
331-356 2.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.19e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907156467 331 HLSEHVRIHTGEKPYKCTSCCKTFSH 356
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
231-294 2.31e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 2.31e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907156467 231 KPFRCKECGRAFSQSASLNTHQRIHTGEKPFAC--EECGKAFRHRSSLNQHHRTHTGEKPFTCDKC 294
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKS 97
zf-H2C2_2 pfam13465
Zinc-finger double domain;
415-440 3.21e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.21e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907156467 415 SFKKHQRHHTGEKPYECTECGKSFSY 440
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
247-272 4.48e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.48e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907156467 247 SLNTHQRIHTGEKPFACEECGKAFRH 272
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
275-300 1.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.04e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907156467 275 SLNQHHRTHTGEKPFTCDKCQKAFSQ 300
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
363-384 1.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.08e-03
                          10        20
                  ....*....|....*....|..
gi 1907156467 363 HQRIHTGERPYKCKECGKAFRQ 384
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
116-423 2.12e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 2.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156467 116 EDDIVCSPLKKASSYSDTLESHRatcgkgtrraiwtHKKKRQEgNKLENPESSNVILEQKHRKHKPARKRNKYKLDSIDH 195
Cdd:COG5048    59 EKPSQCSYSGCDKSFSRPLELSR-------------HLRTHHN-NPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLS 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156467 196 PVSCMRARRYP--CNVCEKMFKQPIHLVEHMRTHTGEK-------PFRCKECGRAFSQSASLNTHQRIHTGEKPFACEEC 266
Cdd:COG5048   125 SHSLPPSSRDPqlPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSP 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156467 267 GKAFRHRSSLNQHHRTHTGEKPFTCDKCQKAFSQNISLVQHLRTHSGEKPFSCSECGKPFRQIRHLSEHVRIHTGE---- 342
Cdd:COG5048   205 LSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssek 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156467 343 ---KPYKCTSCCKTFSHRAYLTHHQR--IHTGE--RPYKCKE--CGKAFRQRIHLSNHRTVHTGVKAYEC--NRCGKAYR 411
Cdd:COG5048   285 gfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFS 364

                         330
                  ....*....|..
gi 1907156467 412 HDSSFKKHQRHH 423
Cdd:COG5048   365 PLLNNEPPQSLQ 376
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 429-451 3.75e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 3.75e-03
                          10        20
                  ....*....|....*....|...
gi 1907156467 429 YECTECGKSFSYNSSLSRHQKIH 451
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 369-449 6.35e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 6.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156467 369 GERPYKCK--ECGKAFRQRIHLSNHRtVHtgvkayecNRCGKAYRHDSSFKKHQRHHTGEKPYECTECGKSFSYNSSLSR 446
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1907156467 447 HQK 449
Cdd:COG5189   417 HRK 419
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 261-283 6.97e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 6.97e-03
                          10        20
                  ....*....|....*....|...
gi 1907156467 261 FACEECGKAFRHRSSLNQHHRTH 283
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
205-451 7.81e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 7.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156467 205 YPCNVCEKMFKQPIHLVEHMRTHTGEKPFRCKECGRAFSQSASLN--THQRIHTGEKPFACE----------------EC 266
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPSDLNSkslplsnskasssslsSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156467 267 GKAFRHRSSLNQHHRTHTGEKPFTCD--------------------KCQKAFSQNISLVQ---------------HLRTH 311
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDllsisnlrnnplpgnnsssvNTPQSNSLHPPLPAnslskdpssnlslliSSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156467 312 SGEKPFSCSECGKPFRQIRHLSEHVRIHTGEKPYKCTSCCKTFSHRAYLTHHQRIHTGERPYKCKECGKAFRQRIHLSNH 391
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSS 273

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907156467 392 RTVHTGV-------KAYECNRCGKAYRHDSSFKKHQR--HHTGE--KPYECTE--CGKSFSYNSSLSRHQKIH 451
Cdd:COG5048   274 SPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 233-255 9.35e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.35e-03
                          10        20
                  ....*....|....*....|...
gi 1907156467 233 FRCKECGRAFSQSASLNTHQRIH 255
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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