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Conserved domains on  [gi|1920277262|ref|XP_036696418|]
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interleukin-1 receptor accessory protein-like 1 [Balaenoptera musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig1_IL1RAPL-1_like cd05896
First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory ...
 196-300 3.20e-68

First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. IL1RAPL is encoded by a gene on the X-chromosome, this gene is wholly or partially deleted in multiple cases of non-syndromic intellectual disability. This group also contains IL1RAPL-2 which is also encoded by a gene on the X-chromosome and is a candidate for another non-syndromic intellectual disability loci.


:

Pssm-ID: 409477  Cd Length: 105  Bit Score: 221.36  E-value: 3.20e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 196 TDWSVDIKKYQVLVGEPVRIKCALFYGYIRANYSLAQSAGLSLMWYKSSGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQ 275
Cdd:cd05896     1 TDWSVDLKKYMVLAGEPVRIKCALFYGYIRTNYSMAQSAGLSLMWYKSSGPGDFEEPIIFDGVRMSKEEDSIWFRPAELQ 80

                          90       100
                  ....*....|....*....|....*
gi 1920277262 276 DSGLYACVIRNSTYCMKVSISLTVG 300
Cdd:cd05896    81 DSGLYTCVLRNSTYCMKVSMSLTVA 105
TIR super family cl23801
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 569-723 2.11e-20

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


The actual alignment was detected with superfamily member pfam01582:

Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 88.96  E-value: 2.11e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 569 YDAYLSYTkvdpdqwnqETGEEERFALEILPDMleKHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYvVR 648
Cdd:pfam01582   1 YDVFLSFR---------GSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNY-AS 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 649 RGWSIFELETRLRNMLvTGEIKVILIE-------CSELRGIMnyqeVEALKHTIKLLT---VIKWHG----------PKC 708
Cdd:pfam01582  69 SGWCLDELVKILECAL-DLGQKVIPIFyevdpsdVRKQTGSF----GKAFKKHKKVLTeekVLKWRGalnevaniwhSKS 143

                         170
                  ....*....|....*
gi 1920277262 709 NKLNSKFWKRLQYEM 723
Cdd:pfam01582 144 VSDESKFWKKIAYDI 158
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 312-398 9.25e-18

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05757:

Pssm-ID: 472250  Cd Length: 92  Bit Score: 78.91  E-value: 9.25e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 312 MKYFDKAELSKSKEISCRDIEDFLLPSREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGG----F 387
Cdd:cd05757     1 PRYKQKLPITKGGKITCPDLDDYKNENVLPPIQWYKDCKPLQGDKRFIPKGSKLLIQNVTEEDAGNYTCKFTYTHngkqY 80

                          90
                  ....*....|.
gi 1920277262 388 VVRRTTELTVT 398
Cdd:cd05757    81 NVTRTISLTVT 91
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 419-514 2.87e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 49.04  E-value: 2.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262  419 QETQLGDSANLTCRAffgySGDVSPLIYWMK-GEKFIedldenrVWESDIRILKEHLgeqevSISLIVDSVEEGDLGNYS 497
Cdd:smart00410   4 VTVKEGESVTLSCEA----SGSPPPEVTWYKqGGKLL-------AESGRFSVSRSGS-----TSTLTISNVTPEDSGTYT 67

                           90
                   ....*....|....*..
gi 1920277262  498 CYVENGNGRRHASVLLH 514
Cdd:smart00410  68 CAATNSSGSASSGTTLT 84
 
Name Accession Description Interval E-value
Ig1_IL1RAPL-1_like cd05896
First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory ...
 196-300 3.20e-68

First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. IL1RAPL is encoded by a gene on the X-chromosome, this gene is wholly or partially deleted in multiple cases of non-syndromic intellectual disability. This group also contains IL1RAPL-2 which is also encoded by a gene on the X-chromosome and is a candidate for another non-syndromic intellectual disability loci.


Pssm-ID: 409477  Cd Length: 105  Bit Score: 221.36  E-value: 3.20e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 196 TDWSVDIKKYQVLVGEPVRIKCALFYGYIRANYSLAQSAGLSLMWYKSSGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQ 275
Cdd:cd05896     1 TDWSVDLKKYMVLAGEPVRIKCALFYGYIRTNYSMAQSAGLSLMWYKSSGPGDFEEPIIFDGVRMSKEEDSIWFRPAELQ 80

                          90       100
                  ....*....|....*....|....*
gi 1920277262 276 DSGLYACVIRNSTYCMKVSISLTVG 300
Cdd:cd05896    81 DSGLYTCVLRNSTYCMKVSMSLTVA 105
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 569-723 2.11e-20

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 88.96  E-value: 2.11e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 569 YDAYLSYTkvdpdqwnqETGEEERFALEILPDMleKHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYvVR 648
Cdd:pfam01582   1 YDVFLSFR---------GSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNY-AS 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 649 RGWSIFELETRLRNMLvTGEIKVILIE-------CSELRGIMnyqeVEALKHTIKLLT---VIKWHG----------PKC 708
Cdd:pfam01582  69 SGWCLDELVKILECAL-DLGQKVIPIFyevdpsdVRKQTGSF----GKAFKKHKKVLTeekVLKWRGalnevaniwhSKS 143

                         170
                  ....*....|....*
gi 1920277262 709 NKLNSKFWKRLQYEM 723
Cdd:pfam01582 144 VSDESKFWKKIAYDI 158
TIR smart00255
Toll - interleukin 1 - resistance;
569-724 8.00e-19

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 83.53  E-value: 8.00e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262  569 YDAYLSYTKVDPdqwnqetgeeerFALEILPDMLEKHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYvVR 648
Cdd:smart00255   2 YDVFISYSGKED------------VRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNY-AE 68

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1920277262  649 RGWSIFELETRLRNMLVTGEIKVILIECSElrgimNYQEVEALKHTIKLL---TVIKWHGPKCNklnsKFWKRLQYEMP 724
Cdd:smart00255  69 SEWCLDELVAALENALEEGGLRVIPIFYEV-----IPSDVRKQPGKFRKVfkkNYLKWPEDEKE----QFWKKALYAVP 138
Ig2_IL1R-like cd05757
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 312-398 9.25e-18

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409415  Cd Length: 92  Bit Score: 78.91  E-value: 9.25e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 312 MKYFDKAELSKSKEISCRDIEDFLLPSREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGG----F 387
Cdd:cd05757     1 PRYKQKLPITKGGKITCPDLDDYKNENVLPPIQWYKDCKPLQGDKRFIPKGSKLLIQNVTEEDAGNYTCKFTYTHngkqY 80

                          90
                  ....*....|.
gi 1920277262 388 VVRRTTELTVT 398
Cdd:cd05757    81 NVTRTISLTVT 91
PHA02785 PHA02785
IL-beta-binding protein; Provisional
 173-498 1.18e-16

IL-beta-binding protein; Provisional


Pssm-ID: 165149 [Multi-domain]  Cd Length: 326  Bit Score: 81.99  E-value: 1.18e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 173 ILLYATFTQSLkvvtkrgSADGCTDWSVDIKKYQVLVGEPVRIKCALFyGYIRANYSLaqsagLSLMWYKSSGPGDFEEP 252
Cdd:PHA02785   11 IFFYSSFVQTF-------NAPECIDKGQYFASFMELENEPVILPCPQI-NTLSSGYNI-----LDILWEKRGADNDRIIP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 253 IAfDGSRMskeedsIWFRPTLlQDSGLYACVIRNSTYCMKVSISLT---VGENDTGLcynskMKYFDKAELSKSKEISCR 329
Cdd:PHA02785   78 ID-NGSNM------LILNPTQ-SDSGIYICITKNETYCDMMSLNLTivsVSESNIDL-----ISYPQIVNERSTGEMVCP 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 330 DIEDFLLPSREPEILW--YKECRTKTWR---PSIVfkrdtlLIREVREDDIGNYTCELK--YGG--FVVRRTTELTVTAP 400
Cdd:PHA02785  145 NINAFIASNVNADIIWsgHRRLRNKRLKqrtPGII------TIEDVRKNDAGYYTCVLKyiYGDktYNVTRIVKLEVRDR 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 401 LTdkPPKLLYPmesklTIQETQLGDSANLTCRAFFgYSGDVSPLIYWMKGEKFIEDLDE---------NRVWESDIRilk 471
Cdd:PHA02785  219 II--PPTMQLP-----EGVVTSIGSNLTIACRVSL-RPPTTDADVFWISNGMYYEEDDEdgdgrisvaNKIYTTDKR--- 287

                         330       340
                  ....*....|....*....|....*..
gi 1920277262 472 ehlgeQEVSISLIVDSVEEGDLGNYSC 498
Cdd:PHA02785  288 -----RVITSRLNINPVKEEDATTFTC 309
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 419-514 2.87e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 49.04  E-value: 2.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262  419 QETQLGDSANLTCRAffgySGDVSPLIYWMK-GEKFIedldenrVWESDIRILKEHLgeqevSISLIVDSVEEGDLGNYS 497
Cdd:smart00410   4 VTVKEGESVTLSCEA----SGSPPPEVTWYKqGGKLL-------AESGRFSVSRSGS-----TSTLTISNVTPEDSGTYT 67

                           90
                   ....*....|....*..
gi 1920277262  498 CYVENGNGRRHASVLLH 514
Cdd:smart00410  68 CAATNSSGSASSGTTLT 84
I-set pfam07679
Immunoglobulin I-set domain;
412-514 3.91e-07

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 48.79  E-value: 3.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 412 MESKLTIQETQLGDSANLTCRAffgySGDVSPLIYWMKGEKFIEDldenrvwESDIRILKEhlgeqEVSISLIVDSVEEG 491
Cdd:pfam07679   3 FTQKPKDVEVQEGESARFTCTV----TGTPDPEVSWFKDGQPLRS-------SDRFKVTYE-----GGTYTLTISNVQPD 66

                          90       100
                  ....*....|....*....|...
gi 1920277262 492 DLGNYSCYVENGNGRRHASVLLH 514
Cdd:pfam07679  67 DSGKYTCVATNSAGEAEASAELT 89
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 325-397 2.57e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 43.26  E-value: 2.57e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1920277262  325 EISCRdiedfLLPSREPEILWYKECRTK-TWRPSIVFKRD----TLLIREVREDDIGNYTCELKYGGFVVRRTTELTV 397
Cdd:smart00410  13 TLSCE-----ASGSPPPEVTWYKQGGKLlAESGRFSVSRSgstsTLTISNVTPEDSGTYTCAATNSSGSASSGTTLTV 85
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 427-510 3.98e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 42.32  E-value: 3.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 427 ANLTCRAffgySGDVSPLIYWMKGEKFIEDLDENRVwesdirilkehlGEQEVSISLIVDSVEEGDLGNYSCYVENGNGR 506
Cdd:cd00096     1 VTLTCSA----SGNPPPTITWYKNGKPLPPSSRDSR------------RSELGNGTLTISNVTLEDSGTYTCVASNSAGG 64


                  ....
gi 1920277262 507 RHAS 510
Cdd:cd00096    65 SASA 68
Ig_6 pfam18452
Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 ...
 240-285 9.44e-05

Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra). IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nine beta-strands and contains at least one intra-domain disulfide bond.


Pssm-ID: 465773  Cd Length: 128  Bit Score: 42.79  E-value: 9.44e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1920277262 240 WYKSSGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIR 285
Cdd:pfam18452  48 WYWQPKNGDPLEAITESSPHIIQEGNALWFLPVGVNDSGSYICRPR 93
PHA02826 PHA02826
IL-1 receptor-like protein; Provisional
 265-385 1.50e-04

IL-1 receptor-like protein; Provisional


Pssm-ID: 165173 [Multi-domain]  Cd Length: 227  Bit Score: 44.14  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 265 DSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSkmkyfdkaelSKSKEISCRDIEDFLLPSREPEIL 344
Cdd:PHA02826   98 ENLWIGNVINIDEGIYICTISSGNICEESTIRLTFDSGTINYQFNS----------GKDSKLHCYGTDGISSTFKDYTLT 167

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1920277262 345 WYKECRTKTWRPSIVFKRD--TLLIREVREDDIGNYTCELKYG 385
Cdd:PHA02826  168 WYKNGNIVLYTDRIQLRNNnsTLVIKSATHDDSGIYTCNLRFN 210
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 340-397 1.07e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 38.53  E-value: 1.07e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1920277262 340 EPEILWYKECrtktwrpSIVFKRDTLLIREVREDDIGNYTCELKYG-GFVVRRTTELTV 397
Cdd:pfam13895  28 PPSYTWYKDG-------SAISSSPNFFTLSVSAEDSGTYTCVARNGrGGKVSNPVELTV 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 203-299 1.40e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.64  E-value: 1.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262  203 KKYQVLVGEPVRIKCalfygyiranySLAQSAGLSLMWYKSSGpgdfeEPIAFDG---SRMSKEEDSIWFRPTLLQDSGL 279
Cdd:smart00410   2 PSVTVKEGESVTLSC-----------EASGSPPPEVTWYKQGG-----KLLAESGrfsVSRSGSTSTLTISNVTPEDSGT 65

                           90       100
                   ....*....|....*....|
gi 1920277262  280 YACVIRNSTYCMKVSISLTV 299
Cdd:smart00410  66 YTCAATNSSGSASSGTTLTV 85
 
Name Accession Description Interval E-value
Ig1_IL1RAPL-1_like cd05896
First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory ...
 196-300 3.20e-68

First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. IL1RAPL is encoded by a gene on the X-chromosome, this gene is wholly or partially deleted in multiple cases of non-syndromic intellectual disability. This group also contains IL1RAPL-2 which is also encoded by a gene on the X-chromosome and is a candidate for another non-syndromic intellectual disability loci.


Pssm-ID: 409477  Cd Length: 105  Bit Score: 221.36  E-value: 3.20e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 196 TDWSVDIKKYQVLVGEPVRIKCALFYGYIRANYSLAQSAGLSLMWYKSSGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQ 275
Cdd:cd05896     1 TDWSVDLKKYMVLAGEPVRIKCALFYGYIRTNYSMAQSAGLSLMWYKSSGPGDFEEPIIFDGVRMSKEEDSIWFRPAELQ 80

                          90       100
                  ....*....|....*....|....*
gi 1920277262 276 DSGLYACVIRNSTYCMKVSISLTVG 300
Cdd:cd05896    81 DSGLYTCVLRNSTYCMKVSMSLTVA 105
Ig1_IL1R_like cd05756
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 196-300 9.86e-42

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


Pssm-ID: 409414  Cd Length: 96  Bit Score: 147.57  E-value: 9.86e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 196 TDWSVDIKKYQVLVGEPVRIKCALFYGYiranysLAQSAGLSLMWYKSsgpgDFEEPIAFD-GSRMSKEEDSIWFRPTLL 274
Cdd:cd05756     1 DEWGEDIKILVVLEGEPDVIKCPLFPNF------LAQSAGLNLTWYKN----DSETPISFEpDSRIHQEKDKLWFVPALL 70

                          90       100
                  ....*....|....*....|....*.
gi 1920277262 275 QDSGLYACVIRNSTYCMKVSISLTVG 300
Cdd:cd05756    71 EDSGNYYCVVRNSTYCSKVSISLEVV 96
Ig1_IL1R_like cd20992
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 197-299 3.22e-32

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


Pssm-ID: 409584  Cd Length: 108  Bit Score: 120.80  E-value: 3.22e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 197 DWSVD-IKKYQVLVGEPVRIKCALFYGYIRANYSLAQSAGLSLMWYKSSGPGDFEEPIAFD--GSRMSKEEDSIWFRPTL 273
Cdd:cd20992     2 DWGLDtMRQIQVFEGEPARIKCPLFEHFLKYNYSTAHSAGLTLIWYWTRQDRDLEEPINFRlpDNRISKEKDVLWFRPTL 81

                          90       100
                  ....*....|....*....|....*.
gi 1920277262 274 LQDSGLYACVIRNSTYCMKVSISLTV 299
Cdd:cd20992    82 LNDTGNYTCMLRNTTYCSKVAFPLEV 107
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 569-723 2.11e-20

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 88.96  E-value: 2.11e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 569 YDAYLSYTkvdpdqwnqETGEEERFALEILPDMleKHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYvVR 648
Cdd:pfam01582   1 YDVFLSFR---------GSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNY-AS 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 649 RGWSIFELETRLRNMLvTGEIKVILIE-------CSELRGIMnyqeVEALKHTIKLLT---VIKWHG----------PKC 708
Cdd:pfam01582  69 SGWCLDELVKILECAL-DLGQKVIPIFyevdpsdVRKQTGSF----GKAFKKHKKVLTeekVLKWRGalnevaniwhSKS 143

                         170
                  ....*....|....*
gi 1920277262 709 NKLNSKFWKRLQYEM 723
Cdd:pfam01582 144 VSDESKFWKKIAYDI 158
TIR smart00255
Toll - interleukin 1 - resistance;
569-724 8.00e-19

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 83.53  E-value: 8.00e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262  569 YDAYLSYTKVDPdqwnqetgeeerFALEILPDMLEKHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYvVR 648
Cdd:smart00255   2 YDVFISYSGKED------------VRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNY-AE 68

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1920277262  649 RGWSIFELETRLRNMLVTGEIKVILIECSElrgimNYQEVEALKHTIKLL---TVIKWHGPKCNklnsKFWKRLQYEMP 724
Cdd:smart00255  69 SEWCLDELVAALENALEEGGLRVIPIFYEV-----IPSDVRKQPGKFRKVfkkNYLKWPEDEKE----QFWKKALYAVP 138
Ig2_IL1R-like cd05757
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 312-398 9.25e-18

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409415  Cd Length: 92  Bit Score: 78.91  E-value: 9.25e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 312 MKYFDKAELSKSKEISCRDIEDFLLPSREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGG----F 387
Cdd:cd05757     1 PRYKQKLPITKGGKITCPDLDDYKNENVLPPIQWYKDCKPLQGDKRFIPKGSKLLIQNVTEEDAGNYTCKFTYTHngkqY 80

                          90
                  ....*....|.
gi 1920277262 388 VVRRTTELTVT 398
Cdd:cd05757    81 NVTRTISLTVT 91
PHA02785 PHA02785
IL-beta-binding protein; Provisional
 173-498 1.18e-16

IL-beta-binding protein; Provisional


Pssm-ID: 165149 [Multi-domain]  Cd Length: 326  Bit Score: 81.99  E-value: 1.18e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 173 ILLYATFTQSLkvvtkrgSADGCTDWSVDIKKYQVLVGEPVRIKCALFyGYIRANYSLaqsagLSLMWYKSSGPGDFEEP 252
Cdd:PHA02785   11 IFFYSSFVQTF-------NAPECIDKGQYFASFMELENEPVILPCPQI-NTLSSGYNI-----LDILWEKRGADNDRIIP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 253 IAfDGSRMskeedsIWFRPTLlQDSGLYACVIRNSTYCMKVSISLT---VGENDTGLcynskMKYFDKAELSKSKEISCR 329
Cdd:PHA02785   78 ID-NGSNM------LILNPTQ-SDSGIYICITKNETYCDMMSLNLTivsVSESNIDL-----ISYPQIVNERSTGEMVCP 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 330 DIEDFLLPSREPEILW--YKECRTKTWR---PSIVfkrdtlLIREVREDDIGNYTCELK--YGG--FVVRRTTELTVTAP 400
Cdd:PHA02785  145 NINAFIASNVNADIIWsgHRRLRNKRLKqrtPGII------TIEDVRKNDAGYYTCVLKyiYGDktYNVTRIVKLEVRDR 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 401 LTdkPPKLLYPmesklTIQETQLGDSANLTCRAFFgYSGDVSPLIYWMKGEKFIEDLDE---------NRVWESDIRilk 471
Cdd:PHA02785  219 II--PPTMQLP-----EGVVTSIGSNLTIACRVSL-RPPTTDADVFWISNGMYYEEDDEdgdgrisvaNKIYTTDKR--- 287

                         330       340
                  ....*....|....*....|....*..
gi 1920277262 472 ehlgeQEVSISLIVDSVEEGDLGNYSC 498
Cdd:PHA02785  288 -----RVITSRLNINPVKEEDATTFTC 309
Ig1_IL1R_like cd20991
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 237-296 1.35e-11

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. IL-1 receptor antagonist (IL-1RA), a naturally occurring cytokine, is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


Pssm-ID: 409583  Cd Length: 91  Bit Score: 61.54  E-value: 1.35e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1920277262 237 SLMWYKSsgpgDFEEPIAFD-GSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSIS 296
Cdd:cd20991    31 TITWYKN----DSKTPISMEqDSRIHQYKEKLWFVPAKVEDSGHYYCVVRNSTYCLKIKIT 87
Ig2_IL-1RAP_like cd20993
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 324-399 6.81e-09

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409585  Cd Length: 93  Bit Score: 53.75  E-value: 6.81e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1920277262 324 KEISCRDIEDFLLPSREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKY--GGFVVRRTTELTVTA 399
Cdd:cd20993    14 RTITCPDLDGIKPPSVSPTVTWYHECNAFGNFNDRVPKGDKLVIHVMLEHYQGNYTCVVTYetKGRTIKLTRTVNVKV 91
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 419-514 2.87e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 49.04  E-value: 2.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262  419 QETQLGDSANLTCRAffgySGDVSPLIYWMK-GEKFIedldenrVWESDIRILKEHLgeqevSISLIVDSVEEGDLGNYS 497
Cdd:smart00410   4 VTVKEGESVTLSCEA----SGSPPPEVTWYKqGGKLL-------AESGRFSVSRSGS-----TSTLTISNVTPEDSGTYT 67

                           90
                   ....*....|....*..
gi 1920277262  498 CYVENGNGRRHASVLLH 514
Cdd:smart00410  68 CAATNSSGSASSGTTLT 84
I-set pfam07679
Immunoglobulin I-set domain;
412-514 3.91e-07

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 48.79  E-value: 3.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 412 MESKLTIQETQLGDSANLTCRAffgySGDVSPLIYWMKGEKFIEDldenrvwESDIRILKEhlgeqEVSISLIVDSVEEG 491
Cdd:pfam07679   3 FTQKPKDVEVQEGESARFTCTV----TGTPDPEVSWFKDGQPLRS-------SDRFKVTYE-----GGTYTLTISNVQPD 66

                          90       100
                  ....*....|....*....|...
gi 1920277262 492 DLGNYSCYVENGNGRRHASVLLH 514
Cdd:pfam07679  67 DSGKYTCVATNSAGEAEASAELT 89
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 587-676 5.12e-07

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 49.24  E-value: 5.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 587 TGEEERFALEILPDmLEKHyGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYvVRRGWSIFELETRLRnmLVT 666
Cdd:pfam13676   6 AGEDRAWAEWLADA-LEAA-GYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNY-LESPWCRAEWEAALA--DPE 80

                          90
                  ....*....|..
gi 1920277262 667 GEIKVI--LIEC 676
Cdd:pfam13676  81 GRKRLIpvRLEC 92
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 405-502 7.94e-07

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 47.56  E-value: 7.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 405 PPKLLYPMESkltiQETQLGDSANLTCRAffgySGDVSPLIYWMKGEKFIEDLDENRVWESDirilkehlgeqeVSISLI 484
Cdd:pfam13927   1 KPVITVSPSS----VTVREGETVTLTCEA----TGSPPPTITWYKNGEPISSGSTRSRSLSG------------SNSTLT 60

                          90
                  ....*....|....*...
gi 1920277262 485 VDSVEEGDLGNYSCYVEN 502
Cdd:pfam13927  61 ISNVTRSDAGTYTCVASN 78
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 420-505 7.03e-06

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 44.88  E-value: 7.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 420 ETQLGDSANLTCRAFFGYSGdvsPLIYWMKGEKFIEDLDENRVWESDIRIlkehlgeqevsISLIVDSVEEGDLGNYSCY 499
Cdd:pfam00047   7 TVLEGDSATLTCSASTGSPG---PDVTWSKEGGTLIESLKVKHDNGRTTQ-----------SSLLISNVTKEDAGTYTCV 72


                  ....*.
gi 1920277262 500 VENGNG 505
Cdd:pfam00047  73 VNNPGG 78
Ig2_IL1R_like cd20994
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 312-397 1.28e-05

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409586  Cd Length: 94  Bit Score: 44.38  E-value: 1.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 312 MKYFDKAELSKSKEISCRDIEDFLLPSRE-PEILWYKECRT---KTWRpsIVFKRDTLLIREVREDDIGNYTCELKY--- 384
Cdd:cd20994     1 DFYKQKVPFTSGGRIVCPHLDFFKDENNNlPKVQWYKDCKPlllDDKR--FAGLESDLLIFNVTVQDQGNYTCHTSYtym 78

                          90
                  ....*....|....
gi 1920277262 385 -GGFVVRRTTELTV 397
Cdd:cd20994    79 gKQYNISRTISLIV 92
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 325-397 2.57e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 43.26  E-value: 2.57e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1920277262  325 EISCRdiedfLLPSREPEILWYKECRTK-TWRPSIVFKRD----TLLIREVREDDIGNYTCELKYGGFVVRRTTELTV 397
Cdd:smart00410  13 TLSCE-----ASGSPPPEVTWYKQGGKLlAESGRFSVSRSgstsTLTISNVTPEDSGTYTCAATNSSGSASSGTTLTV 85
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 427-510 3.98e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 42.32  E-value: 3.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 427 ANLTCRAffgySGDVSPLIYWMKGEKFIEDLDENRVwesdirilkehlGEQEVSISLIVDSVEEGDLGNYSCYVENGNGR 506
Cdd:cd00096     1 VTLTCSA----SGNPPPTITWYKNGKPLPPSSRDSR------------RSELGNGTLTISNVTLEDSGTYTCVASNSAGG 64


                  ....
gi 1920277262 507 RHAS 510
Cdd:cd00096    65 SASA 68
Ig_6 pfam18452
Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 ...
 240-285 9.44e-05

Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra). IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nine beta-strands and contains at least one intra-domain disulfide bond.


Pssm-ID: 465773  Cd Length: 128  Bit Score: 42.79  E-value: 9.44e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1920277262 240 WYKSSGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIR 285
Cdd:pfam18452  48 WYWQPKNGDPLEAITESSPHIIQEGNALWFLPVGVNDSGSYICRPR 93
PHA02826 PHA02826
IL-1 receptor-like protein; Provisional
 265-385 1.50e-04

IL-1 receptor-like protein; Provisional


Pssm-ID: 165173 [Multi-domain]  Cd Length: 227  Bit Score: 44.14  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 265 DSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSkmkyfdkaelSKSKEISCRDIEDFLLPSREPEIL 344
Cdd:PHA02826   98 ENLWIGNVINIDEGIYICTISSGNICEESTIRLTFDSGTINYQFNS----------GKDSKLHCYGTDGISSTFKDYTLT 167

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1920277262 345 WYKECRTKTWRPSIVFKRD--TLLIREVREDDIGNYTCELKYG 385
Cdd:PHA02826  168 WYKNGNIVLYTDRIQLRNNnsTLVIKSATHDDSGIYTCNLRFN 210
IgI_3_Robo cd05725
Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...
 419-513 1.85e-04

Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, Robo3), and three mammalian Slit homologs (Slit-1,Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, and Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409390 [Multi-domain]  Cd Length: 83  Bit Score: 40.84  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 419 QETQLGDSANLTCRAffgySGDVSPLIYWMKgekfiedlDENRVWESDIRILKEHlgeqevsiSLIVDSVEEGDLGNYSC 498
Cdd:cd05725     7 QVVLVDDSAEFQCEV----GGDPVPTVRWRK--------EDGELPKGRYEILDDH--------SLKIRKVTAGDMGSYTC 66

                          90
                  ....*....|....*
gi 1920277262 499 YVENGNGRRHASVLL 513
Cdd:cd05725    67 VAENMVGKIEASATL 81
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 340-397 1.07e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 38.53  E-value: 1.07e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1920277262 340 EPEILWYKECrtktwrpSIVFKRDTLLIREVREDDIGNYTCELKYG-GFVVRRTTELTV 397
Cdd:pfam13895  28 PPSYTWYKDG-------SAISSSPNFFTLSVSAEDSGTYTCVARNGrGGKVSNPVELTV 79
Ig_C5_MyBP-C cd05894
C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C); The members here ...
 438-513 1.39e-03

C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C); The members here are composed of the C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C). MyBP-C consists of repeated domains, Ig and fibronectin type 3, and various linkers. Three isoforms of MYBP-C exist: slow-skeletal (ssMyBP-C), fast-skeletal (fsMyBP-C), and cardiac (cMyBP-C). cMYBP-C has insertions between and inside domains and an additional cardiac-specific Ig domain at the N-terminus. For cMYBP_C an interaction has been demonstrated between this C5 domain and the Ig C8 domain.


Pssm-ID: 409475  Cd Length: 86  Bit Score: 38.67  E-value: 1.39e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1920277262 438 SGDVSPLIYWMKGEKFIEDlDENRVwesdirilkeHLGEQEVSISLIVDSVEEGDLGNYSCYVENGNGRRHASVLL 513
Cdd:cd05894    20 SGEPAPTVTWSRGDKAFTA-TEGRV----------RVESYKDLSSFVIEGAEREDEGVYTITVTNPVGEDHASLFV 84
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 203-299 1.40e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.64  E-value: 1.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262  203 KKYQVLVGEPVRIKCalfygyiranySLAQSAGLSLMWYKSSGpgdfeEPIAFDG---SRMSKEEDSIWFRPTLLQDSGL 279
Cdd:smart00410   2 PSVTVKEGESVTLSC-----------EASGSPPPEVTWYKQGG-----KLLAESGrfsVSRSGSTSTLTISNVTPEDSGT 65

                           90       100
                   ....*....|....*....|
gi 1920277262  280 YACVIRNSTYCMKVSISLTV 299
Cdd:smart00410  66 YTCAATNSSGSASSGTTLTV 85
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 340-381 2.67e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 37.31  E-value: 2.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1920277262 340 EPEILWYKE----CRTKTWRPSIVFKRDTLLIREVREDDIGNYTCE 381
Cdd:cd00096    12 PPTITWYKNgkplPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCV 57
IgI_Myomesin_like_C cd05737
C-terminal immunoglobulin (Ig)-like domain of myomesin and M-protein; member of the I-set of ...
 417-505 2.81e-03

C-terminal immunoglobulin (Ig)-like domain of myomesin and M-protein; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the C-terminal immunoglobulin (Ig)-like domain of myomesin and M-protein (also known as myomesin-2). Myomesin and M-protein are both structural proteins localized to the M-band, a transverse structure in the center of the sarcomere, and are candidates for M-band bridges. Both proteins are modular, consisting mainly of repetitive Ig-like and fibronectin type III (FnIII) domains. Myomesin is expressed in all types of vertebrate striated muscle; M-protein has a muscle-type specific expression pattern. Myomesin is present in both slow and fast fibers; M-protein is present only in fast fibers. It has been suggested that myomesin acts as a molecular spring with alternative splicing as a means of modifying its elasticity.


Pssm-ID: 319300  Cd Length: 92  Bit Score: 37.96  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1920277262 417 TIQEtqlGDSANLTCRAFfgysGDVSPLIYWMKGEKFIEDLDENRVWEsdirilkehlgEQEVSISLIVDSVEEGDLGNY 496
Cdd:cd05737    12 TIME---GKTLNLTCNVW----GDPPPEVSWLKNDQALAFLDHCNLKV-----------EAGRTVYFTINGVSSEDSGKY 73


                  ....*....
gi 1920277262 497 SCYVENGNG 505
Cdd:cd05737    74 GLVVKNKYG 82
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 340-381 7.02e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.39  E-value: 7.02e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1920277262 340 EPEILWYKE----CRTKTWRPSIVFKRDTLLIREVREDDIGNYTCE 381
Cdd:pfam13927  30 PPTITWYKNgepiSSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCV 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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