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Conserved domains on  [gi|1958787714|ref|XP_038934337|]
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phospholipid phosphatase 2 isoform X2 [Rattus norvegicus]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 256)

type 2 phosphatidic acid phosphatase (PAP2) family protein may be a histidine phosphatase or a vanadium haloperoxidase, and is predicted to be a transmembrane protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_like super family cl00474
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 94-172 5.85e-21

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


The actual alignment was detected with superfamily member cd03384:

Pssm-ID: 469784  Cd Length: 150  Bit Score: 83.83  E-value: 5.85e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958787714  94 AIYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPSFLAVCDPDWSRVNCSGYVQVEV----CRGSPANVTEASStcrpgSAG 169
Cdd:cd03384     1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIAdctcCTGDPDLIREARL-----SFP 75


                  ...
gi 1958787714 170 SGH 172
Cdd:cd03384    76 SGH 78
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 94-172 5.85e-21

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 83.83  E-value: 5.85e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958787714  94 AIYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPSFLAVCDPDWSRVNCSGYVQVEV----CRGSPANVTEASStcrpgSAG 169
Cdd:cd03384     1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIAdctcCTGDPDLIREARL-----SFP 75


                  ...
gi 1958787714 170 SGH 172
Cdd:cd03384    76 SGH 78
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 94-172 5.85e-21

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 83.83  E-value: 5.85e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958787714  94 AIYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPSFLAVCDPDWSRVNCSGYVQVEV----CRGSPANVTEASStcrpgSAG 169
Cdd:cd03384     1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIAdctcCTGDPDLIREARL-----SFP 75


                  ...
gi 1958787714 170 SGH 172
Cdd:cd03384    76 SGH 78
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 42-134 1.32e-06

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 46.44  E-value: 1.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958787714  42 SIRYPYRPDTITHGLMAGVIITATVVLVSSGEAYLVYTDRLysrsDFNNYVAAiykvlgtFLFGAAVSQSLTDLAKYMIG 121
Cdd:cd03390     2 SISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLW----DLHTSLLG-------LLLSVSLNGVITNVLKNYAG 70

                          90
                  ....*....|...
gi 1958787714 122 RLRPSFLAVCDPD 134
Cdd:cd03390    71 RPRPDFLARCFPD 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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