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Conserved domains on  [gi|1958789217|ref|XP_038934967|]
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host cell factor 2 isoform X2 [Rattus norvegicus]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 15620386)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-332 1.28e-18

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 85.21  E-value: 1.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217  14 SFTGPVPRARHGHRAVAIRELMIIFGGGNEG-IADELHVYNTVTNQWflpaVRGDIPPGCAAHGFVC--DGTRILVFGGM 90
Cdd:COG3055     4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGsASNSFEVYDPATNTW----SELAPLPGPPRHHAAAvaQDGKLYVFGGF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217  91 VEY---GRYSNELYELQASRWLWKKVkpqpppsGLPPCPRLGHSFSLYGNKCYLFAGlanesedsnNNVPRYLNDFYELE 167
Cdd:COG3055    80 TGAnpsSTPLNDVYVYDPATNTWTKL-------APMPTPRGGATALLLDGKIYVVGG---------WDDGGNVAWVEVYD 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217 168 LQHGSgvvgWSvpaTKGTVPSPRESHTAVIyckrdSGSPKMYVFGGMCGARLDDLWqldletmswskpETKGTVPLPRSL 247
Cdd:COG3055   144 PATGT----WT---QLAPLPTPRDHLAAAV-----LPDGKILVIGGRNGSGFSNTW------------TTLAPLPTARAG 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217 248 HTASVIGNKMYIFGGwvphkgentENSPHDCEWRctssfsyLNLDTAEWTTLvsdsqedkkNSRPRPRAGHCAVAIGTRL 327
Cdd:COG3055   200 HAAAVLGGKILVFGG---------ESGFSDEVEA-------YDPATNTWTAL---------GELPTPRHGHAAVLTDGKV 254


                  ....*
gi 1958789217 328 YFWSG 332
Cdd:COG3055   255 YVIGG 259
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 312-355 1.11e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


:

Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 36.39  E-value: 1.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958789217 312 PRPRAGHCAVAIGTRLYFWSGRDGYkkalNSQVcCKDLWYLDTE 355
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGG----EGQP-SDDVYVLSLP 39
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-332 1.28e-18

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 85.21  E-value: 1.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217  14 SFTGPVPRARHGHRAVAIRELMIIFGGGNEG-IADELHVYNTVTNQWflpaVRGDIPPGCAAHGFVC--DGTRILVFGGM 90
Cdd:COG3055     4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGsASNSFEVYDPATNTW----SELAPLPGPPRHHAAAvaQDGKLYVFGGF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217  91 VEY---GRYSNELYELQASRWLWKKVkpqpppsGLPPCPRLGHSFSLYGNKCYLFAGlanesedsnNNVPRYLNDFYELE 167
Cdd:COG3055    80 TGAnpsSTPLNDVYVYDPATNTWTKL-------APMPTPRGGATALLLDGKIYVVGG---------WDDGGNVAWVEVYD 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217 168 LQHGSgvvgWSvpaTKGTVPSPRESHTAVIyckrdSGSPKMYVFGGMCGARLDDLWqldletmswskpETKGTVPLPRSL 247
Cdd:COG3055   144 PATGT----WT---QLAPLPTPRDHLAAAV-----LPDGKILVIGGRNGSGFSNTW------------TTLAPLPTARAG 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217 248 HTASVIGNKMYIFGGwvphkgentENSPHDCEWRctssfsyLNLDTAEWTTLvsdsqedkkNSRPRPRAGHCAVAIGTRL 327
Cdd:COG3055   200 HAAAVLGGKILVFGG---------ESGFSDEVEA-------YDPATNTWTAL---------GELPTPRHGHAAVLTDGKV 254


                  ....*
gi 1958789217 328 YFWSG 332
Cdd:COG3055   255 YVIGG 259
PLN02193 PLN02193
nitrile-specifier protein
 2-262 3.00e-11

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 64.98  E-value: 3.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217   2 AAPSLL-NWRRV-SSFTGPVPRARHGHRAVAIRelMIIFGGG---NEGIADELHVYNTVTNQWFLPAVRGDIPP-GCAAH 75
Cdd:PLN02193  145 STPKLLgKWIKVeQKGEGPGLRCSHGIAQVGNK--IYSFGGEftpNQPIDKHLYVFDLETRTWSISPATGDVPHlSCLGV 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217  76 GFVCDGTRILVFGGMvEYGRYSNELYELQASRWLWKKVkpqpPPSGLPPCPRLGHSFSLYGNKCYLFAGLANESE----D 151
Cdd:PLN02193  223 RMVSIGSTLYVFGGR-DASRQYNGFYSFDTTTNEWKLL----TPVEEGPTPRSFHSMAADEENVYVFGGVSATARlktlD 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217 152 SNNNVPRylndfyelelqhgsgvvGWSVPATkgtvpsPRESHTAVIYCKRDSGSPKMYVFGGMCGARLDDLWQLDLETMS 231
Cdd:PLN02193  298 SYNIVDK-----------------KWFHCST------PGDSFSIRGGAGLEVVQGKVWVVYGFNGCEVDDVHYYDPVQDK 354

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1958789217 232 WSKPETKGTVPLPRSLHTASVIGNKMYIFGG 262
Cdd:PLN02193  355 WTQVETFGVRPSERSVFASAAVGKHIVIFGG 385
Kelch_3 pfam13415
Galactose oxidase, central domain;
207-253 1.93e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 44.59  E-value: 1.93e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958789217 207 KMYVFGGMC---GARLDDLWQLDLETMSWSKPetkGTVPLPRSLHTASVI 253
Cdd:pfam13415   3 KLYIFGGLGfdgQTRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 312-355 1.11e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 36.39  E-value: 1.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958789217 312 PRPRAGHCAVAIGTRLYFWSGRDGYkkalNSQVcCKDLWYLDTE 355
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGG----EGQP-SDDVYVLSLP 39
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-332 1.28e-18

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 85.21  E-value: 1.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217  14 SFTGPVPRARHGHRAVAIRELMIIFGGGNEG-IADELHVYNTVTNQWflpaVRGDIPPGCAAHGFVC--DGTRILVFGGM 90
Cdd:COG3055     4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGsASNSFEVYDPATNTW----SELAPLPGPPRHHAAAvaQDGKLYVFGGF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217  91 VEY---GRYSNELYELQASRWLWKKVkpqpppsGLPPCPRLGHSFSLYGNKCYLFAGlanesedsnNNVPRYLNDFYELE 167
Cdd:COG3055    80 TGAnpsSTPLNDVYVYDPATNTWTKL-------APMPTPRGGATALLLDGKIYVVGG---------WDDGGNVAWVEVYD 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217 168 LQHGSgvvgWSvpaTKGTVPSPRESHTAVIyckrdSGSPKMYVFGGMCGARLDDLWqldletmswskpETKGTVPLPRSL 247
Cdd:COG3055   144 PATGT----WT---QLAPLPTPRDHLAAAV-----LPDGKILVIGGRNGSGFSNTW------------TTLAPLPTARAG 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217 248 HTASVIGNKMYIFGGwvphkgentENSPHDCEWRctssfsyLNLDTAEWTTLvsdsqedkkNSRPRPRAGHCAVAIGTRL 327
Cdd:COG3055   200 HAAAVLGGKILVFGG---------ESGFSDEVEA-------YDPATNTWTAL---------GELPTPRHGHAAVLTDGKV 254


                  ....*
gi 1958789217 328 YFWSG 332
Cdd:COG3055   255 YVIGG 259
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
9-264 7.52e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 80.20  E-value: 7.52e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217   9 WRRVSSFTGPvprARHGHRAVAIRELMIIFGG-----GNEGIADELHVYNTVTNQWFlpaVRGDIPPGCAAHGFVCDGTR 83
Cdd:COG3055    50 WSELAPLPGP---PRHHAAAVAQDGKLYVFGGftganPSSTPLNDVYVYDPATNTWT---KLAPMPTPRGGATALLLDGK 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217  84 ILVFGGMVEYGRYSN-ELYELQASRWlwKKVKPQPPPsglppcpRLGHS-FSLYGNKCYLFAGlANESEDSNNnvpryln 161
Cdd:COG3055   124 IYVVGGWDDGGNVAWvEVYDPATGTW--TQLAPLPTP-------RDHLAaAVLPDGKILVIGG-RNGSGFSNT------- 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217 162 dfyelelqhgsgvvgWSvpaTKGTVPSPRESHTAVIYckrdsgSPKMYVFGGMCGArLDDLWQLDLETMSWSkpeTKGTV 241
Cdd:COG3055   187 ---------------WT---TLAPLPTARAGHAAAVL------GGKILVFGGESGF-SDEVEAYDPATNTWT---ALGEL 238

                         250       260
                  ....*....|....*....|...
gi 1958789217 242 PLPRSLHTASVIGNKMYIFGGWV 264
Cdd:COG3055   239 PTPRHGHAAVLTDGKVYVIGGET 261
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
134-335 2.35e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 75.58  E-value: 2.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217 134 LYGNKCYLFAGLANESedsnnnvprYLNDFYELELQHGSgvvgWSvpaTKGTVPSPRESHTAVIYCKRdsgspKMYVFGG 213
Cdd:COG3055    20 LLDGKVYVAGGLSGGS---------ASNSFEVYDPATNT----WS---ELAPLPGPPRHHAAAVAQDG-----KLYVFGG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217 214 MCGAR-----LDDLWQLDLETMSWSKpetKGTVPLPRSLHTASVIGNKMYIFGGWVPHKGentensphdcewrcTSSFSY 288
Cdd:COG3055    79 FTGANpsstpLNDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGGN--------------VAWVEV 141

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1958789217 289 LNLDTAEWTTLVSDsqedkknsrPRPRAGHCA-VAIGTRLYFWSGRDG 335
Cdd:COG3055   142 YDPATGTWTQLAPL---------PTPRDHLAAaVLPDGKILVIGGRNG 180
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
66-336 5.66e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 74.81  E-value: 5.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217  66 GDIP-PGCAAHGFVCDGtRILVFGGMvEYGRYSNELYELQASRWLWKKVKPQPPPsglppcpRLGHSFS-LYGNKCYLFA 143
Cdd:COG3055     7 PDLPtPRSEAAAALLDG-KVYVAGGL-SGGSASNSFEVYDPATNTWSELAPLPGP-------PRHHAAAvAQDGKLYVFG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217 144 GLaneseDSNNNVPRYLNDFYELELQHGSgvvgWSvpaTKGTVPSPRESHTAVIYckrdsgSPKMYVFGGMCGA-RLDDL 222
Cdd:COG3055    78 GF-----TGANPSSTPLNDVYVYDPATNT----WT---KLAPMPTPRGGATALLL------DGKIYVVGGWDDGgNVAWV 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217 223 WQLDLETMSWSkpeTKGTVPLPRSLHTASVIGN-KMYIFGGwvphkgentensphdcewrcTSSFSYLNldtaEWTTLvs 301
Cdd:COG3055   140 EVYDPATGTWT---QLAPLPTPRDHLAAAVLPDgKILVIGG--------------------RNGSGFSN----TWTTL-- 190

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1958789217 302 dsqedkkNSRPRPRAGHCAVAIGTRLYFWSGRDGY 336
Cdd:COG3055   191 -------APLPTARAGHAAAVLGGKILVFGGESGF 218
PLN02193 PLN02193
nitrile-specifier protein
 2-262 3.00e-11

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 64.98  E-value: 3.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217   2 AAPSLL-NWRRV-SSFTGPVPRARHGHRAVAIRelMIIFGGG---NEGIADELHVYNTVTNQWFLPAVRGDIPP-GCAAH 75
Cdd:PLN02193  145 STPKLLgKWIKVeQKGEGPGLRCSHGIAQVGNK--IYSFGGEftpNQPIDKHLYVFDLETRTWSISPATGDVPHlSCLGV 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217  76 GFVCDGTRILVFGGMvEYGRYSNELYELQASRWLWKKVkpqpPPSGLPPCPRLGHSFSLYGNKCYLFAGLANESE----D 151
Cdd:PLN02193  223 RMVSIGSTLYVFGGR-DASRQYNGFYSFDTTTNEWKLL----TPVEEGPTPRSFHSMAADEENVYVFGGVSATARlktlD 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217 152 SNNNVPRylndfyelelqhgsgvvGWSVPATkgtvpsPRESHTAVIYCKRDSGSPKMYVFGGMCGARLDDLWQLDLETMS 231
Cdd:PLN02193  298 SYNIVDK-----------------KWFHCST------PGDSFSIRGGAGLEVVQGKVWVVYGFNGCEVDDVHYYDPVQDK 354

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1958789217 232 WSKPETKGTVPLPRSLHTASVIGNKMYIFGG 262
Cdd:PLN02193  355 WTQVETFGVRPSERSVFASAAVGKHIVIFGG 385
PLN02153 PLN02153
epithiospecifier protein
 16-264 2.95e-09

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 58.07  E-value: 2.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217  16 TGPVPRARHGHRAVAirELMIIFGGG---NEGIADELHVYNTVTNQWFLPAVRGDIPP-GCAAHGFVCDGTRILVFGGMV 91
Cdd:PLN02153   18 KGPGPRCSHGIAVVG--DKLYSFGGElkpNEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGRD 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217  92 EYGRYSN-ELYELQASRWLWkkvkPQPPPSGLPPCPRLGHSFSLYGNKCYLFAGLaneSEDSNNNVPRYLNDFYELELQH 170
Cdd:PLN02153   96 EKREFSDfYSYDTVKNEWTF----LTKLDEEGGPEARTFHSMASDENHVYVFGGV---SKGGLMKTPERFRTIEAYNIAD 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217 171 GsgvvGWSvpatkgTVPSPRESHTA--------------VIYCKRDSGSPkmyvfGGMCGARLDDLWQLDLETMSWSKPE 236
Cdd:PLN02153  169 G----KWV------QLPDPGENFEKrggagfavvqgkiwVVYGFATSILP-----GGKSDYESNAVQFFDPASGKWTEVE 233

                         250       260
                  ....*....|....*....|....*...
gi 1958789217 237 TKGTVPLPRSLHTASVIGNKMYIFGGWV 264
Cdd:PLN02153  234 TTGAKPSARSVFAHAVVGKYIIIFGGEV 261
PLN02153 PLN02153
epithiospecifier protein
 17-268 7.14e-08

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 53.84  E-value: 7.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217  17 GPVPR-ARHGHRAVAIRELMIIFGGGNEGIA-DELHVYNTVTNQW-FLPAVrgDIPPGCAA---HGFVCDGTRILVFGGM 90
Cdd:PLN02153   69 GDVPRiSCLGVRMVAVGTKLYIFGGRDEKREfSDFYSYDTVKNEWtFLTKL--DEEGGPEArtfHSMASDENHVYVFGGV 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217  91 VEYG------RYSN-ELYELQASRWLwkkvkpQPPPSGLPPCPRLGHSFSLYGNKCYLFAGLANESedsnnnVPRYLNDF 163
Cdd:PLN02153  147 SKGGlmktpeRFRTiEAYNIADGKWV------QLPDPGENFEKRGGAGFAVVQGKIWVVYGFATSI------LPGGKSDY 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217 164 YELELQHGSGVVG-WSVPATKGTVPSPRE--SHTAViyckrdsgSPKMYVFGGMC----------GARLDDLWQLDLETM 230
Cdd:PLN02153  215 ESNAVQFFDPASGkWTEVETTGAKPSARSvfAHAVV--------GKYIIIFGGEVwpdlkghlgpGTLSNEGYALDTETL 286

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1958789217 231 SWSKPETKGTVPLPR---SLHTASVIG-NKMYIFGGWVPHKG 268
Cdd:PLN02153  287 VWEKLGECGEPAMPRgwtAYTTATVYGkNGLLMHGGKLPTNE 328
PLN02193 PLN02193
nitrile-specifier protein
 232-375 3.21e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 52.27  E-value: 3.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217 232 WSKPETKGTVPLPRSLHTASVIGNKMYIFGgwvphkGENTENSPHDcewrctSSFSYLNLDTAEWTtlVSDSQEDKKNSR 311
Cdd:PLN02193  153 WIKVEQKGEGPGLRCSHGIAQVGNKIYSFG------GEFTPNQPID------KHLYVFDLETRTWS--ISPATGDVPHLS 218

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958789217 312 PrprAGHCAVAIGTRLYFWSGRDGYKK--ALNSQVCCKDLWYLDT--EKPPAPSQVQLIKATTNSFHV 375
Cdd:PLN02193  219 C---LGVRMVSIGSTLYVFGGRDASRQynGFYSFDTTTNEWKLLTpvEEGPTPRSFHSMAADEENVYV 283
PLN02193 PLN02193
nitrile-specifier protein
 77-262 1.36e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 50.34  E-value: 1.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217  77 FVCDGTRILVFggmveYGRYSNELYELQASRWL---------WKKVKPQPPPSGLppcpRLGHSFSLYGNKCYLFAGlan 147
Cdd:PLN02193  116 FVLQGGKIVGF-----HGRSTDVLHSLGAYISLpstpkllgkWIKVEQKGEGPGL----RCSHGIAQVGNKIYSFGG--- 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217 148 eSEDSNNNVPRYLNDFyELELQhgsgvvGWSVPATKGTVPspresHTAVIYCKRDSGSPKMYVFGGMCGAR-LDDLWQLD 226
Cdd:PLN02193  184 -EFTPNQPIDKHLYVF-DLETR------TWSISPATGDVP-----HLSCLGVRMVSIGSTLYVFGGRDASRqYNGFYSFD 250

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1958789217 227 LETMSWS--KPETKGtvPLPRSLHTASVIGNKMYIFGG 262
Cdd:PLN02193  251 TTTNEWKllTPVEEG--PTPRSFHSMAADEENVYVFGG 286
Kelch_3 pfam13415
Galactose oxidase, central domain;
207-253 1.93e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 44.59  E-value: 1.93e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958789217 207 KMYVFGGMC---GARLDDLWQLDLETMSWSKPetkGTVPLPRSLHTASVI 253
Cdd:pfam13415   3 KLYIFGGLGfdgQTRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
PRK14131 PRK14131
N-acetylneuraminate epimerase;
9-89 8.52e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 47.70  E-value: 8.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217   9 WRRVSSFTGPvprARHGHRAVAIRELMIIFGG----GNEG---IADELHVYNTVTNQWFLPAVRGdiPPGCAAH-GFVCD 80
Cdd:PRK14131   64 WTKIAAFPGG---PREQAVAAFIDGKLYVFGGigktNSEGspqVFDDVYKYDPKTNSWQKLDTRS--PVGLAGHvAVSLH 138


                  ....*....
gi 1958789217  81 GTRILVFGG 89
Cdd:PRK14131  139 NGKAYITGG 147
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
17-104 1.07e-05

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 46.69  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217  17 GPVPRARHGHRAVAIRELMIIFGGGNeGIADELHVYNTVTNQWFlpaVRGDIPPGCAAHGFVCDGTRILVFGGMVEYGRY 96
Cdd:COG3055   191 APLPTARAGHAAAVLGGKILVFGGES-GFSDEVEAYDPATNTWT---ALGELPTPRHGHAAVLTDGKVYVIGGETKPGVR 266


                  ....*...
gi 1958789217  97 SNELYELQ 104
Cdd:COG3055   267 TPLVTSAE 274
PLN02153 PLN02153
epithiospecifier protein
 232-334 4.73e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 41.90  E-value: 4.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217 232 WSKPETKG-TVPLPRSLHTASVIGNKMYIFGGwvphkgENTENSPHDcewrctSSFSYLNLDTAEWttlvsdSQEDKKNS 310
Cdd:PLN02153    9 WIKVEQKGgKGPGPRCSHGIAVVGDKLYSFGG------ELKPNEHID------KDLYVFDFNTHTW------SIAPANGD 70

                          90       100
                  ....*....|....*....|....*
gi 1958789217 311 RPRPRA-GHCAVAIGTRLYFWSGRD 334
Cdd:PLN02153   71 VPRISClGVRMVAVGTKLYIFGGRD 95
Kelch_3 pfam13415
Galactose oxidase, central domain;
254-323 5.03e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 37.65  E-value: 5.03e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217 254 GNKMYIFGGWVPHKGEntensphdcewrCTSSFSYLNLDTAEWTTLvsdsqedkkNSRPRPRAGHCAVAI 323
Cdd:pfam13415   1 GDKLYIFGGLGFDGQT------------RLNDLYVYDLDTNTWTQI---------GDLPPPRSGHSATYI 49
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 244-301 8.42e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.82  E-value: 8.42e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958789217 244 PRSLHTASVIGNKMYIFGGWvphkgentensphdCEWRCTSSFSYLNLDTAEWTTLVS 301
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGF--------------DGNQSLNSVEVYDPETNTWSKLPS 44
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 312-355 1.11e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 36.39  E-value: 1.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958789217 312 PRPRAGHCAVAIGTRLYFWSGRDGYkkalNSQVcCKDLWYLDTE 355
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGG----EGQP-SDDVYVLSLP 39
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
231-337 1.22e-03

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 40.52  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789217 231 SWSkpeTKGTVPLPRSLHTASVIGNKMYIFGGWVphkgentensphdcEWRCTSSFSYLNLDTAEWTTLVSDSQEdkkns 310
Cdd:COG3055     2 TWS---SLPDLPTPRSEAAAALLDGKVYVAGGLS--------------GGSASNSFEVYDPATNTWSELAPLPGP----- 59

                          90       100
                  ....*....|....*....|....*..
gi 1958789217 311 rprPRAGHCAVAIGTRLYFWSGRDGYK 337
Cdd:COG3055    60 ---PRHHAAAVAQDGKLYVFGGFTGAN 83
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 187-229 1.55e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 36.00  E-value: 1.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958789217 187 PSPRESHTAVIYckrdsgSPKMYVFGGMCGAR---LDDLWQLDLET 229
Cdd:pfam13854   1 PVPRYGHCAVTV------GDYIYLYGGYTGGEgqpSDDVYVLSLPT 40
Kelch_4 pfam13418
Galactose oxidase, central domain;
189-234 2.92e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.67  E-value: 2.92e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1958789217 189 PRESHTAViYCKRDSGspkmYVFGGMC--GARLDDLWQLDLETMSWSK 234
Cdd:pfam13418   1 PRAYHTST-SIPDDTI----YLFGGEGedGTLLSDLWVFDLSTNEWTR 43
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 22-59 4.82e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 34.90  E-value: 4.82e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958789217  22 ARHGHRAVAIRELMIIFGGGNEGIA-DELHVYNTVTNQW 59
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSlNSVEVYDPETNTW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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