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Conserved domains on  [gi|1958661125|ref|XP_038942857|]
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pyruvate dehydrogenase kinase, isozyme 2 isoform X2 [Rattus norvegicus]

Protein Classification

PDK/BCKDK family protein kinase( domain architecture ID 13768654)

PDK/BCKDK family protein kinase contains a histidine kinase-like ATPase domain and catalyzes the phosphorylation of protein substrates, such as branched-chain alpha-ketoacid dehydrogenase (BCKD) kinase that catalyzes the phosphorylation and inactivation of the BCKD complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways

CATH:  3.30.565.10|1.20.140.20
EC:  2.7.11.-
Gene Ontology:  GO:0004672|GO:0005524|GO:0006468
PubMed:  10339418|10637609

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 175-340 1.34e-86

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


:

Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 259.58  E-value: 1.34e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 175 SVSDVVKDAYDMAKLLCDKYYMASPDLEIQEVNatnatqPIHMVYVPSHLYHMLFELFKNAMRATVESHE-SSLTLPPIK 253
Cdd:cd16929     1 SPKKVVEDASEEARVLCDDYYLSSPELEIEGDP------SIRFPYVPSHLYYILFELLKNAMRATVESHGdDSDDLPPIK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 254 IMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQ--------PGTGGTPLAGFGYGLPISRLYAKYFQGDLQL 325
Cdd:cd16929    75 VTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSlddfsdliSGTQPSPLAGFGYGLPMSRLYAEYFGGDLDL 154

                         170
                  ....*....|....*
gi 1958661125 326 FSMEGFGTDAVIYLK 340
Cdd:cd16929   155 QSMEGYGTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 27-171 6.93e-64

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


:

Pssm-ID: 463093  Cd Length: 158  Bit Score: 201.19  E-value: 6.93e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125  27 TSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHrtlSQFTDALVTIRNRHNDVV 106
Cdd:pfam10436  21 KSANFLREELPVRLAHRIRELQNLPYILVSNPSISKVYEWYLQSFEELLSFPPPILEDN---EKFTELLEEILDRHNDVV 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958661125 107 PTMAQGVLEYKDTYgddpvSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKH-IGSID 171
Cdd:pfam10436  98 PTLAQGVLELKKYL-----SPEEIQSFLDRFLRSRIGIRLLAEQHIALTEQSNNPSHPPDyVGIID 158
 
Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 175-340 1.34e-86

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 259.58  E-value: 1.34e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 175 SVSDVVKDAYDMAKLLCDKYYMASPDLEIQEVNatnatqPIHMVYVPSHLYHMLFELFKNAMRATVESHE-SSLTLPPIK 253
Cdd:cd16929     1 SPKKVVEDASEEARVLCDDYYLSSPELEIEGDP------SIRFPYVPSHLYYILFELLKNAMRATVESHGdDSDDLPPIK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 254 IMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQ--------PGTGGTPLAGFGYGLPISRLYAKYFQGDLQL 325
Cdd:cd16929    75 VTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSlddfsdliSGTQPSPLAGFGYGLPMSRLYAEYFGGDLDL 154

                         170
                  ....*....|....*
gi 1958661125 326 FSMEGFGTDAVIYLK 340
Cdd:cd16929   155 QSMEGYGTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 27-171 6.93e-64

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


Pssm-ID: 463093  Cd Length: 158  Bit Score: 201.19  E-value: 6.93e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125  27 TSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHrtlSQFTDALVTIRNRHNDVV 106
Cdd:pfam10436  21 KSANFLREELPVRLAHRIRELQNLPYILVSNPSISKVYEWYLQSFEELLSFPPPILEDN---EKFTELLEEILDRHNDVV 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958661125 107 PTMAQGVLEYKDTYgddpvSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKH-IGSID 171
Cdd:pfam10436  98 PTLAQGVLELKKYL-----SPEEIQSFLDRFLRSRIGIRLLAEQHIALTEQSNNPSHPPDyVGIID 158
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 221-340 1.00e-19

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 83.47  E-value: 1.00e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125  221 PSHLYHMLFELFKNAMRATVEShessltlPPIKIMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGtggt 300
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEG-------GRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKI---- 71

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1958661125  301 plAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLK 340
Cdd:smart00387  72 --GGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITLP 109
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 220-340 3.10e-15

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 71.25  E-value: 3.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 220 VPSHLYHMLFELFKNAMRATVESHESSLTLppikimvaLGEEDLSIKMSDRGGGVPLRKIERLFSyMYSTAPTPQPGtgg 299
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGEITVTL--------SEGGELTLTVEDNGIGIPPEDLPRIFE-PFSTADKRGGG--- 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1958661125 300 tplaGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLK 340
Cdd:pfam02518  70 ----GTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTLP 106
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
174-339 1.74e-10

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 60.69  E-value: 1.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 174 CSVSDVVKDAYDMAKLLCDKYYmaspdleiQEVNATNATQPIHMVYVPSHLYHMLFELFKNAMRATVEShessltlPPIK 253
Cdd:COG2205    91 VDLAELLEEAVEELRPLAEEKG--------IRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPG-------GTIT 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 254 IMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGtggtplaGFGYGLPISRLYAKYFQGDLQLFSMEGFGT 333
Cdd:COG2205   156 ISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEG-------GTGLGLAIVKRIVEAHGGTIWVESEPGGGT 228


                  ....*.
gi 1958661125 334 DAVIYL 339
Cdd:COG2205   229 TFTVTL 234
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 214-333 3.49e-06

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 49.17  E-value: 3.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 214 PIHMVYVPSHLYHMLFELFKNAMRATvesHESSLTLPpikiMVALGEEDLSIKMSDRGGGVPLRKIERLFSyMYSTAPTp 293
Cdd:PRK11091  389 PHKVITDGTRLRQILWNLISNAVKFT---QQGGVTVR----VRYEEGDMLTFEVEDSGIGIPEDELDKIFA-MYYQVKD- 459

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1958661125 294 qpGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGT 333
Cdd:PRK11091  460 --SHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGS 497
 
Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 175-340 1.34e-86

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 259.58  E-value: 1.34e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 175 SVSDVVKDAYDMAKLLCDKYYMASPDLEIQEVNatnatqPIHMVYVPSHLYHMLFELFKNAMRATVESHE-SSLTLPPIK 253
Cdd:cd16929     1 SPKKVVEDASEEARVLCDDYYLSSPELEIEGDP------SIRFPYVPSHLYYILFELLKNAMRATVESHGdDSDDLPPIK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 254 IMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQ--------PGTGGTPLAGFGYGLPISRLYAKYFQGDLQL 325
Cdd:cd16929    75 VTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSlddfsdliSGTQPSPLAGFGYGLPMSRLYAEYFGGDLDL 154

                         170
                  ....*....|....*
gi 1958661125 326 FSMEGFGTDAVIYLK 340
Cdd:cd16929   155 QSMEGYGTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 27-171 6.93e-64

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


Pssm-ID: 463093  Cd Length: 158  Bit Score: 201.19  E-value: 6.93e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125  27 TSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHrtlSQFTDALVTIRNRHNDVV 106
Cdd:pfam10436  21 KSANFLREELPVRLAHRIRELQNLPYILVSNPSISKVYEWYLQSFEELLSFPPPILEDN---EKFTELLEEILDRHNDVV 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958661125 107 PTMAQGVLEYKDTYgddpvSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKH-IGSID 171
Cdd:pfam10436  98 PTLAQGVLELKKYL-----SPEEIQSFLDRFLRSRIGIRLLAEQHIALTEQSNNPSHPPDyVGIID 158
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 221-340 1.00e-19

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 83.47  E-value: 1.00e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125  221 PSHLYHMLFELFKNAMRATVEShessltlPPIKIMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGtggt 300
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEG-------GRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKI---- 71

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1958661125  301 plAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLK 340
Cdd:smart00387  72 --GGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITLP 109
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 220-340 3.10e-15

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 71.25  E-value: 3.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 220 VPSHLYHMLFELFKNAMRATVESHESSLTLppikimvaLGEEDLSIKMSDRGGGVPLRKIERLFSyMYSTAPTPQPGtgg 299
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGEITVTL--------SEGGELTLTVEDNGIGIPPEDLPRIFE-PFSTADKRGGG--- 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1958661125 300 tplaGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLK 340
Cdd:pfam02518  70 ----GTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTLP 106
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
174-339 1.74e-10

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 60.69  E-value: 1.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 174 CSVSDVVKDAYDMAKLLCDKYYmaspdleiQEVNATNATQPIHMVYVPSHLYHMLFELFKNAMRATVEShessltlPPIK 253
Cdd:COG2205    91 VDLAELLEEAVEELRPLAEEKG--------IRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPG-------GTIT 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 254 IMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGtggtplaGFGYGLPISRLYAKYFQGDLQLFSMEGFGT 333
Cdd:COG2205   156 ISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEG-------GTGLGLAIVKRIVEAHGGTIWVESEPGGGT 228


                  ....*.
gi 1958661125 334 DAVIYL 339
Cdd:COG2205   229 TFTVTL 234
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
175-339 2.93e-10

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 61.08  E-value: 2.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 175 SVSDVVKDAYDMAKLLCdkyymASPDLEIQevnaTNATQPIHMVYV-PSHLYHMLFELFKNAMRATVESHessltlpPIK 253
Cdd:COG0642   183 DLAELLEEVVELFRPLA-----EEKGIELE----LDLPDDLPTVRGdPDRLRQVLLNLLSNAIKYTPEGG-------TVT 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 254 IMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGtggtplaGFGYGLPISRLYAKYFQGDLQLFSMEGFGT 333
Cdd:COG0642   247 VSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG-------GTGLGLAIVKRIVELHGGTIEVESEPGKGT 319


                  ....*.
gi 1958661125 334 DAVIYL 339
Cdd:COG0642   320 TFTVTL 325
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 174-339 1.11e-06

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 50.18  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 174 CSVSDVVKDAYDMAKllcdkyymasPDLEIQEVN-ATNATQPIHMVYV-PSHLYHMLFELFKNAMRATVESHEssltlPP 251
Cdd:COG4191   215 VDLNELIDEALELLR----------PRLKARGIEvELDLPPDLPPVLGdPGQLEQVLLNLLINAIDAMEEGEG-----GR 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 252 IKIMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQpGTGgtpLagfgyGLPISRLYAKYFQGDLQLFSMEGF 331
Cdd:COG4191   280 ITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPVGK-GTG---L-----GLSISYGIVEKHGGRIEVESEPGG 350


                  ....*...
gi 1958661125 332 GTDAVIYL 339
Cdd:COG4191   351 GTTFTITL 358
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 231-339 1.70e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 46.13  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 231 LFKNAMRATVESHEssltlPPIKIMVALGEE--DLSIKMSDRGGGVPLRKIERLFSYMYSTAPTpqpgtggtplAGFGYG 308
Cdd:cd16915     8 LIDNALDALAATGA-----PNKQVEVFLRDEgdDLVIEVRDTGPGIAPELRDKVFERGVSTKGQ----------GERGIG 72

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958661125 309 LPISRLYAKYFQGDLQLFSMEGFGTDAVIYL 339
Cdd:cd16915    73 LALVRQSVERLGGSITVESEPGGGTTFSIRI 103
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 214-333 3.49e-06

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 49.17  E-value: 3.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 214 PIHMVYVPSHLYHMLFELFKNAMRATvesHESSLTLPpikiMVALGEEDLSIKMSDRGGGVPLRKIERLFSyMYSTAPTp 293
Cdd:PRK11091  389 PHKVITDGTRLRQILWNLISNAVKFT---QQGGVTVR----VRYEEGDMLTFEVEDSGIGIPEDELDKIFA-MYYQVKD- 459

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1958661125 294 qpGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGT 333
Cdd:PRK11091  460 --SHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGS 497
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 224-339 4.53e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 45.09  E-value: 4.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 224 LYHMLFELFKNAMRATVESHessltlppiKIMVALGEEDLS-IKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTggtpl 302
Cdd:cd16940    14 LFLLLRNLVDNAVRYSPQGS---------RVEIKLSADDGAvIRVEDNGPGIDEEELEALFERFYRSDGQNYGGS----- 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1958661125 303 agfGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL 339
Cdd:cd16940    80 ---GLGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 231-339 7.24e-06

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 47.65  E-value: 7.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 231 LFKNAMRATVEShessltlPPIKIMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTpqpGTggtplagfGYGLP 310
Cdd:COG5000   325 LLKNAIEAIEEG-------GEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPK---GT--------GLGLA 386

                          90       100
                  ....*....|....*....|....*....
gi 1958661125 311 ISRLYAKYFQGDLQLFSMEGFGTDAVIYL 339
Cdd:COG5000   387 IVKKIVEEHGGTIELESRPGGGTTFTIRL 415
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 252-325 1.24e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 43.60  E-value: 1.24e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958661125 252 IKIMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTaPTPQPGTGGTplagfGYGLPISRLYAKYFQGDLQL 325
Cdd:cd16945    26 IALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSL-PRPHSGQKST-----GLGLAFVQEVAQLHGGRITL 93
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 189-339 1.65e-05

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 46.38  E-value: 1.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 189 LLCDKYYMAS---PDLEIqEVNATNATQPIhmvyVPSHLYHMLFELFKNAMRATVESHESSltlPPIKIMVALGEEDLSI 265
Cdd:COG3290   249 LLLGKAARARergIDLTI-DIDSDLPDLPL----SDTDLVTILGNLLDNAIEAVEKLPEEE---RRVELSIRDDGDELVI 320

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958661125 266 KMSDRGGGVPLRKIERLFSYMYSTaptpqPGTGGTplagfGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL 339
Cdd:COG3290   321 EVEDSGPGIPEELLEKIFERGFST-----KLGEGR-----GLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
174-341 5.50e-05

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 44.93  E-value: 5.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 174 CSVSDVVKDAYDMAKLLCDKYymaspDLEIQevnaTNATQPIHMVYV-PSHLYHMLFELFKNAMRATVESHEssltlppI 252
Cdd:COG5002   240 VDLAELLEEVVEELRPLAEEK-----GIELE----LDLPEDPLLVLGdPDRLEQVLTNLLDNAIKYTPEGGT-------I 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 253 KIMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTplagfGYGLPISRLYAKYFQGDLQLFSMEGFG 332
Cdd:COG5002   304 TVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGT-----GLGLAIVKHIVEAHGGRIWVESEPGKG 378


                  ....*....
gi 1958661125 333 TDAVIYLKA 341
Cdd:COG5002   379 TTFTITLPL 387
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 263-339 3.55e-04

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 40.06  E-value: 3.55e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958661125 263 LSIKMSDRGGGVPLRKIERLFSYMYSTAPTpqpgtggtplaGFGYGLPISRLY--AKYFQGDLQLFSMEGFGTDAVIYL 339
Cdd:cd16919    48 VCLEVSDTGSGMPAEVLRRAFEPFFTTKEV-----------GKGTGLGLSMVYgfVKQSGGHLRIYSEPGVGTTVRIYL 115
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 231-339 5.01e-04

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 41.88  E-value: 5.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 231 LFKNAMRATVEshessltlpPIKIMVALGEED---LSIKMSDRGGGVPLRKIERLFSYMYSTAPTpqpgtgGTplagfGY 307
Cdd:COG5809   387 LLKNAIEAMPE---------GGNITIETKAEDddkVVISVTDEGCGIPEERLKKLGEPFYTTKEK------GT-----GL 446

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958661125 308 GLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL 339
Cdd:COG5809   447 GLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 223-327 1.11e-03

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 41.21  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 223 HLYHMLFELFKNAMRAtveshesSLTLPPIKIMVALGEEDLSIKMSDRGGGVPLrkIERLFSYMYSTAPTpqpgtggtpl 302
Cdd:COG4192   543 LLEQVLVNLLVNALDA-------VATQPQISVDLLSNAENLRVAISDNGNGWPL--VDKLFTPFTTTKEV---------- 603

                          90       100
                  ....*....|....*....|....*
gi 1958661125 303 aGFGYGLPISRLYAKYFQGDLQLFS 327
Cdd:COG4192   604 -GLGLGLSICRSIMQQFGGDLYLAS 627
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 228-333 1.17e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 38.15  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 228 LFELFKNAMRATVESHESSLTLPpIKIMVAlGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTpqpgtggtplaGFGY 307
Cdd:cd16920     5 LINLVRNGIEAMSEGGCERRELT-IRTSPA-DDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE-----------GLGM 71

                          90       100
                  ....*....|....*....|....*.
gi 1958661125 308 GLPISRLYAKYFQGDLQLFSMEGFGT 333
Cdd:cd16920    72 GLSICRSIIEAHGGRLSVESPAGGGA 97
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
228-346 1.69e-03

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 40.34  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 228 LFELFKNAMRATVEShessltlppIKIMVA---LGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTpqpGTggtplag 304
Cdd:PRK11360  505 LLNILINAVQAISAR---------GKIRIRtwqYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAK---GT------- 565

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1958661125 305 fGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDS 346
Cdd:PRK11360  566 -GLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQGN 606
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 227-333 3.10e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 37.09  E-value: 3.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 227 MLFELFKNAMRATVESHessltlppIKIMVALGEED-----LSIKMSDRGGGVPLRKIERLFSyMYSTAPTP-QPGTGGT 300
Cdd:cd16922     4 ILLNLLGNAIKFTEEGE--------VTLRVSLEEEEedgvqLRFSVEDTGIGIPEEQQARLFE-PFSQADSStTRKYGGT 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958661125 301 plagfGYGLPISRLYAKYFQGDLQLFSMEGFGT 333
Cdd:cd16922    75 -----GLGLAISKKLVELMGGDISVESEPGQGS 102
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 228-332 4.76e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 36.28  E-value: 4.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 228 LFELFKNAMRAtVESHESsltlPPIKIMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQpgtggtplaGFGY 307
Cdd:cd16976     5 LMNLLQNALDA-MGKVEN----PRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGK---------GTGL 70

                          90       100
                  ....*....|....*....|....*
gi 1958661125 308 GLPISRLYAKYFQGDLQLFSMEGFG 332
Cdd:cd16976    71 GLSISYGIVEEHGGRLSVANEEGAG 95
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 252-343 4.82e-03

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 39.06  E-value: 4.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 252 IKIMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYStapTPQPGTG--GTplagfGYGLPISRLYAKYFQGDLQLFSME 329
Cdd:PRK11100  390 ITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYS---LPRPANGrkST-----GLGLAFVREVARLHGGEVTLRNRP 461

                          90
                  ....*....|....
gi 1958661125 330 GFGTDAVIYLKALS 343
Cdd:PRK11100  462 EGGVLATLTLPRHF 475
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
221-346 7.03e-03

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 38.29  E-value: 7.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661125 221 PSHLYHMLFELFKNAMRATVESHEssLTL-----PPIKIMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTpqp 295
Cdd:COG3852   242 PDQLIQVLLNLVRNAAEAMPEGGT--ITIrtrveRQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEK--- 316

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958661125 296 GTGgtpLagfgyGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDS 346
Cdd:COG3852   317 GTG---L-----GLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEE 359
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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