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Conserved domains on  [gi|1958748177|ref|XP_038954138|]
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kelch domain-containing protein 4 isoform X3 [Rattus norvegicus]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 11459646)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
3-253 7.27e-25

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 103.70  E-value: 7.27e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177   3 NELYIYSIRKGTWTKV-DIPGPPprrcAHQAVVVPQGGgQLWIFGGEFASPDGEQFYhyKDLWVLHLATKTWEQIRSTgg 81
Cdd:COG3055    38 NSFEVYDPATNTWSELaPLPGPP----RHHAAAVAQDG-KLYVFGGFTGANPSSTPL--NDVYVYDPATNTWTKLAPM-- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177  82 PSGRSGHRMVAWKRQLILFGGFHESTrdYIYYSDVYTFSLDTflWSKLSPSgpgPTPRSGCLMAVTPQGSIAIYGGYskq 161
Cdd:COG3055   109 PTPRGGATALLLDGKIYVVGGWDDGG--NVAWVEVYDPATGT--WTQLAPL---PTPRDHLAAAVLPDGKILVIGGR--- 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177 162 rvkkdvdkgtqhsdmfllkpeDGGEDKWTWTRVNPSgvkPTVRSGFSvAVAPNHQILVFGGvcdeeeeehlEGSFFNDLY 241
Cdd:COG3055   179 ---------------------NGSGFSNTWTTLAPL---PTARAGHA-AAVLGGKILVFGG----------ESGFSDEVE 223

                         250
                  ....*....|..
gi 1958748177 242 IYDAAKSRWFAA 253
Cdd:COG3055   224 AYDPATNTWTAL 235
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
3-253 7.27e-25

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 103.70  E-value: 7.27e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177   3 NELYIYSIRKGTWTKV-DIPGPPprrcAHQAVVVPQGGgQLWIFGGEFASPDGEQFYhyKDLWVLHLATKTWEQIRSTgg 81
Cdd:COG3055    38 NSFEVYDPATNTWSELaPLPGPP----RHHAAAVAQDG-KLYVFGGFTGANPSSTPL--NDVYVYDPATNTWTKLAPM-- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177  82 PSGRSGHRMVAWKRQLILFGGFHESTrdYIYYSDVYTFSLDTflWSKLSPSgpgPTPRSGCLMAVTPQGSIAIYGGYskq 161
Cdd:COG3055   109 PTPRGGATALLLDGKIYVVGGWDDGG--NVAWVEVYDPATGT--WTQLAPL---PTPRDHLAAAVLPDGKILVIGGR--- 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177 162 rvkkdvdkgtqhsdmfllkpeDGGEDKWTWTRVNPSgvkPTVRSGFSvAVAPNHQILVFGGvcdeeeeehlEGSFFNDLY 241
Cdd:COG3055   179 ---------------------NGSGFSNTWTTLAPL---PTARAGHA-AAVLGGKILVFGG----------ESGFSDEVE 223

                         250
                  ....*....|..
gi 1958748177 242 IYDAAKSRWFAA 253
Cdd:COG3055   224 AYDPATNTWTAL 235
PLN02193 PLN02193
nitrile-specifier protein
 13-222 5.38e-19

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 89.63  E-value: 5.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177  13 GTWTKVDIPGPPP-RRCAHQavvVPQGGGQLWIFGGEFaSPDGEQFYHykdLWVLHLATKTWEQIRSTGGPSGRS--GHR 89
Cdd:PLN02193  151 GKWIKVEQKGEGPgLRCSHG---IAQVGNKIYSFGGEF-TPNQPIDKH---LYVFDLETRTWSISPATGDVPHLSclGVR 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177  90 MVAWKRQLILFGGFHESTRdyiyYSDVYTFSLDTFLWSKLSPSGPGPTPRSGCLMAV----------------------- 146
Cdd:PLN02193  224 MVSIGSTLYVFGGRDASRQ----YNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAAdeenvyvfggvsatarlktldsy 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177 147 -----------TPQGSIAIYGGYSKQRVKKDV-----DKGTQHSDMFLLKPedgGEDKwtWTRVNPSGVKPTVRSGFSVA 210
Cdd:PLN02193  300 nivdkkwfhcsTPGDSFSIRGGAGLEVVQGKVwvvygFNGCEVDDVHYYDP---VQDK--WTQVETFGVRPSERSVFASA 374

                         250
                  ....*....|..
gi 1958748177 211 VAPNHqILVFGG 222
Cdd:PLN02193  375 AVGKH-IVIFGG 385
Kelch_3 pfam13415
Galactose oxidase, central domain;
39-92 1.14e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 45.36  E-value: 1.14e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958748177  39 GGQLWIFGGEFasPDGEQFYHykDLWVLHLATKTWEQIRSTggPSGRSGHRMVA 92
Cdd:pfam13415   1 GDKLYIFGGLG--FDGQTRLN--DLYVYDLDTNTWTQIGDL--PPPRSGHSATY 48
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
3-253 7.27e-25

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 103.70  E-value: 7.27e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177   3 NELYIYSIRKGTWTKV-DIPGPPprrcAHQAVVVPQGGgQLWIFGGEFASPDGEQFYhyKDLWVLHLATKTWEQIRSTgg 81
Cdd:COG3055    38 NSFEVYDPATNTWSELaPLPGPP----RHHAAAVAQDG-KLYVFGGFTGANPSSTPL--NDVYVYDPATNTWTKLAPM-- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177  82 PSGRSGHRMVAWKRQLILFGGFHESTrdYIYYSDVYTFSLDTflWSKLSPSgpgPTPRSGCLMAVTPQGSIAIYGGYskq 161
Cdd:COG3055   109 PTPRGGATALLLDGKIYVVGGWDDGG--NVAWVEVYDPATGT--WTQLAPL---PTPRDHLAAAVLPDGKILVIGGR--- 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177 162 rvkkdvdkgtqhsdmfllkpeDGGEDKWTWTRVNPSgvkPTVRSGFSvAVAPNHQILVFGGvcdeeeeehlEGSFFNDLY 241
Cdd:COG3055   179 ---------------------NGSGFSNTWTTLAPL---PTARAGHA-AAVLGGKILVFGG----------ESGFSDEVE 223

                         250
                  ....*....|..
gi 1958748177 242 IYDAAKSRWFAA 253
Cdd:COG3055   224 AYDPATNTWTAL 235
PLN02193 PLN02193
nitrile-specifier protein
 13-222 5.38e-19

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 89.63  E-value: 5.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177  13 GTWTKVDIPGPPP-RRCAHQavvVPQGGGQLWIFGGEFaSPDGEQFYHykdLWVLHLATKTWEQIRSTGGPSGRS--GHR 89
Cdd:PLN02193  151 GKWIKVEQKGEGPgLRCSHG---IAQVGNKIYSFGGEF-TPNQPIDKH---LYVFDLETRTWSISPATGDVPHLSclGVR 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177  90 MVAWKRQLILFGGFHESTRdyiyYSDVYTFSLDTFLWSKLSPSGPGPTPRSGCLMAV----------------------- 146
Cdd:PLN02193  224 MVSIGSTLYVFGGRDASRQ----YNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAAdeenvyvfggvsatarlktldsy 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177 147 -----------TPQGSIAIYGGYSKQRVKKDV-----DKGTQHSDMFLLKPedgGEDKwtWTRVNPSGVKPTVRSGFSVA 210
Cdd:PLN02193  300 nivdkkwfhcsTPGDSFSIRGGAGLEVVQGKVwvvygFNGCEVDDVHYYDP---VQDK--WTQVETFGVRPSERSVFASA 374

                         250
                  ....*....|..
gi 1958748177 211 VAPNHqILVFGG 222
Cdd:PLN02193  375 AVGKH-IVIFGG 385
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
2-222 2.89e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 72.88  E-value: 2.89e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177   2 YNELYIYSIRKGTWTKvdIPGPPPRRCAHQAVVVpqgGGQLWIFGGEFASPdgeqfyHYKDLWVLHLATKTWEQIRSTgg 81
Cdd:COG3055    89 LNDVYVYDPATNTWTK--LAPMPTPRGGATALLL---DGKIYVVGGWDDGG------NVAWVEVYDPATGTWTQLAPL-- 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177  82 PSGRSGHR-MVAWKRQLILFGGFHestrdyiyysdvytFSLDTFLWSKLspsGPGPTPRSGcLMAVTPQGSIAIYGGYSk 160
Cdd:COG3055   156 PTPRDHLAaAVLPDGKILVIGGRN--------------GSGFSNTWTTL---APLPTARAG-HAAAVLGGKILVFGGES- 216

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958748177 161 qrvkkdvdkgTQHSDMFLLKPEDGgedkwTWTRVNPSgvkPTVRSGFsVAVAPNHQILVFGG 222
Cdd:COG3055   217 ----------GFSDEVEAYDPATN-----TWTALGEL---PTPRHGH-AAVLTDGKVYVIGG 259
PLN02153 PLN02153
epithiospecifier protein
 4-250 1.12e-12

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 69.24  E-value: 1.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177   4 ELYIYSIRKGTWTKVDIPGPPPRrCAHQAVVVPQGGGQLWIFGGEFASPDGEQFYHYKDLwvlhlaTKTWE---QIRSTG 80
Cdd:PLN02153   51 DLYVFDFNTHTWSIAPANGDVPR-ISCLGVRMVAVGTKLYIFGGRDEKREFSDFYSYDTV------KNEWTfltKLDEEG 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177  81 GPSGRSGHRMVAWKRQLILFGGFHES--TRDYIYYSDVYTFSLDTFLWSKLSPSGPGPTPRSGCLMAVTpQGSIAIYGGY 158
Cdd:PLN02153  124 GPEARTFHSMASDENHVYVFGGVSKGglMKTPERFRTIEAYNIADGKWVQLPDPGENFEKRGGAGFAVV-QGKIWVVYGF 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177 159 SKQRVKKDVDKGTQHSDMFLlKPEDGgedkwTWTRVNPSGVKPTVRSGFSVAVAPNHqILVFGGVCDEEEEEHL-EGSFF 237
Cdd:PLN02153  203 ATSILPGGKSDYESNAVQFF-DPASG-----KWTEVETTGAKPSARSVFAHAVVGKY-IIIFGGEVWPDLKGHLgPGTLS 275

                         250
                  ....*....|...
gi 1958748177 238 NDLYIYDAAKSRW 250
Cdd:PLN02153  276 NEGYALDTETLVW 288
Kelch_3 pfam13415
Galactose oxidase, central domain;
39-92 1.14e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 45.36  E-value: 1.14e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958748177  39 GGQLWIFGGEFasPDGEQFYHykDLWVLHLATKTWEQIRSTggPSGRSGHRMVA 92
Cdd:pfam13415   1 GDKLYIFGGLG--FDGQTRLN--DLYVYDLDTNTWTQIGDL--PPPRSGHSATY 48
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 82-124 7.76e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 42.94  E-value: 7.76e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1958748177  82 PSGRSGHRMVAWKRQLILFGGFheSTRDYIYYSDVYTFSLDTF 124
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGY--TGGEGQPSDDVYVLSLPTF 41
PLN02153 PLN02153
epithiospecifier protein
 8-139 8.23e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 44.59  E-value: 8.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177   8 YSIRKGTWTKVDIPGPPPRRCAHQAVVVPQGggQLWIFGGeFAS---PDGEQFYHYKDLWVLHLATKTWEQIRSTGG-PS 83
Cdd:PLN02153  164 YNIADGKWVQLPDPGENFEKRGGAGFAVVQG--KIWVVYG-FATsilPGGKSDYESNAVQFFDPASGKWTEVETTGAkPS 240

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958748177  84 GRSGHRMVAWKRQLILFGGfhESTRDY-------IYYSDVYTFSLDTFLWSKLSPSGPGPTPR 139
Cdd:PLN02153  241 ARSVFAHAVVGKYIIIFGG--EVWPDLkghlgpgTLSNEGYALDTETLVWEKLGECGEPAMPR 301
Kelch_3 pfam13415
Galactose oxidase, central domain;
94-146 1.01e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 39.97  E-value: 1.01e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958748177  94 KRQLILFGGFHESTRDYiyYSDVYTFSLDTFLWSKLspsGPGPTPRSGCLMAV 146
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTR--LNDLYVYDLDTNTWTQI---GDLPPPRSGHSATY 48
Kelch_4 pfam13418
Galactose oxidase, central domain;
25-78 1.59e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 39.13  E-value: 1.59e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958748177  25 PRRCaHQAVVVPqgGGQLWIFGGEfaSPDGEQfyhYKDLWVLHLATKTWEQIRS 78
Cdd:pfam13418   1 PRAY-HTSTSIP--DDTIYLFGGE--GEDGTL---LSDLWVFDLSTNEWTRLGS 46
Kelch_6 pfam13964
Kelch motif;
27-76 4.92e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.09  E-value: 4.92e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958748177  27 RCAHQAVVVpqgGGQLWIFGGefaspDGEQFYHYKDLWVLHLATKTWEQI 76
Cdd:pfam13964   2 RTFHSVVSV---GGYIYVFGG-----YTNASPALNKLEVYNPLTKSWEEL 43
PRK14131 PRK14131
N-acetylneuraminate epimerase;
15-116 7.39e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.92  E-value: 7.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958748177  15 WTKV-DIPGPPpRRCAHQAVVvpqgGGQLWIFGGEFASPDGEQFYHYKDLWVLHLATKTWEQIrSTGGPSGRSGHRMVAW 93
Cdd:PRK14131   64 WTKIaAFPGGP-REQAVAAFI----DGKLYVFGGIGKTNSEGSPQVFDDVYKYDPKTNSWQKL-DTRSPVGLAGHVAVSL 137

                          90       100
                  ....*....|....*....|....
gi 1958748177  94 -KRQLILFGGFHESTRDYiYYSDV 116
Cdd:PRK14131  138 hNGKAYITGGVNKNIFDG-YFEDL 160
Kelch_4 pfam13418
Galactose oxidase, central domain;
84-134 1.67e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.44  E-value: 1.67e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958748177  84 GRSGHRMVAW-KRQLILFGGFhesTRDYIYYSDVYTFSLDTFLWSKLSPSGP 134
Cdd:pfam13418   1 PRAYHTSTSIpDDTIYLFGGE---GEDGTLLSDLWVFDLSTNEWTRLGSLPS 49
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 201-244 3.77e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 35.23  E-value: 3.77e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958748177 201 PTVRSGFSVAVApNHQILVFGGVcdeeeeEHLEGSFFNDLYIYD 244
Cdd:pfam13854   1 PVPRYGHCAVTV-GDYIYLYGGY------TGGEGQPSDDVYVLS 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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