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Conserved domains on  [gi|1958757681|ref|XP_038954828|]
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peroxisomal leader peptide-processing protease isoform X1 [Rattus norvegicus]

Protein Classification

serine protease family protein( domain architecture ID 229414)

trypsin-like serine protease family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tryp_SPc super family cl21584
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 358-429 9.63e-05

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


The actual alignment was detected with superfamily member pfam13365:

Pssm-ID: 473915 [Multi-domain]  Cd Length: 142  Bit Score: 42.41  E-value: 9.63e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958757681 358 GSGVAVAPR-LVVTCRHVA--PRETARVLVHSATPRNVAIWGRVVFATQEtspYDIAVVSLEEELNGVPVPVPAE 429
Cdd:pfam13365   1 GTGFVVSSDgLVLTNAHVVddAEEAAVELVSVVLADGREYPATVVARDPD---LDLALLRVSGDGRGLPPLPLGD 72
Tryp_SPc super family cl21584
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 187-268 9.64e-03

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


The actual alignment was detected with superfamily member pfam13365:

Pssm-ID: 473915 [Multi-domain]  Cd Length: 142  Bit Score: 36.63  E-value: 9.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757681 187 FALLRVqrgaAAEERRGPAVTVAPLGAVAKGAPLLACGSPFG----AFCPDIfLNTLSRGVLSNAAGPLLLTDARCLPGT 262
Cdd:pfam13365  53 LALLRV----SGDGRGLPPLPLGDSEPLVGGERVYAVGYPLGgeklSLSEGI-VSGVDEGRDGGDDGRVIQTDAALSPGS 127


                  ....*.
gi 1958757681 263 EGGGVF 268
Cdd:pfam13365 128 SGGPVF 133
 
Name Accession Description Interval E-value
Trypsin_2 pfam13365
Trypsin-like peptidase domain; This family includes trypsin-like peptidase domains.
 358-429 9.63e-05

Trypsin-like peptidase domain; This family includes trypsin-like peptidase domains.


Pssm-ID: 433149 [Multi-domain]  Cd Length: 142  Bit Score: 42.41  E-value: 9.63e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958757681 358 GSGVAVAPR-LVVTCRHVA--PRETARVLVHSATPRNVAIWGRVVFATQEtspYDIAVVSLEEELNGVPVPVPAE 429
Cdd:pfam13365   1 GTGFVVSSDgLVLTNAHVVddAEEAAVELVSVVLADGREYPATVVARDPD---LDLALLRVSGDGRGLPPLPLGD 72
Trypsin_2 pfam13365
Trypsin-like peptidase domain; This family includes trypsin-like peptidase domains.
 187-268 9.64e-03

Trypsin-like peptidase domain; This family includes trypsin-like peptidase domains.


Pssm-ID: 433149 [Multi-domain]  Cd Length: 142  Bit Score: 36.63  E-value: 9.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757681 187 FALLRVqrgaAAEERRGPAVTVAPLGAVAKGAPLLACGSPFG----AFCPDIfLNTLSRGVLSNAAGPLLLTDARCLPGT 262
Cdd:pfam13365  53 LALLRV----SGDGRGLPPLPLGDSEPLVGGERVYAVGYPLGgeklSLSEGI-VSGVDEGRDGGDDGRVIQTDAALSPGS 127


                  ....*.
gi 1958757681 263 EGGGVF 268
Cdd:pfam13365 128 SGGPVF 133
 
Name Accession Description Interval E-value
Trypsin_2 pfam13365
Trypsin-like peptidase domain; This family includes trypsin-like peptidase domains.
 358-429 9.63e-05

Trypsin-like peptidase domain; This family includes trypsin-like peptidase domains.


Pssm-ID: 433149 [Multi-domain]  Cd Length: 142  Bit Score: 42.41  E-value: 9.63e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958757681 358 GSGVAVAPR-LVVTCRHVA--PRETARVLVHSATPRNVAIWGRVVFATQEtspYDIAVVSLEEELNGVPVPVPAE 429
Cdd:pfam13365   1 GTGFVVSSDgLVLTNAHVVddAEEAAVELVSVVLADGREYPATVVARDPD---LDLALLRVSGDGRGLPPLPLGD 72
Trypsin_2 pfam13365
Trypsin-like peptidase domain; This family includes trypsin-like peptidase domains.
 187-268 9.64e-03

Trypsin-like peptidase domain; This family includes trypsin-like peptidase domains.


Pssm-ID: 433149 [Multi-domain]  Cd Length: 142  Bit Score: 36.63  E-value: 9.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757681 187 FALLRVqrgaAAEERRGPAVTVAPLGAVAKGAPLLACGSPFG----AFCPDIfLNTLSRGVLSNAAGPLLLTDARCLPGT 262
Cdd:pfam13365  53 LALLRV----SGDGRGLPPLPLGDSEPLVGGERVYAVGYPLGgeklSLSEGI-VSGVDEGRDGGDDGRVIQTDAALSPGS 127


                  ....*.
gi 1958757681 263 EGGGVF 268
Cdd:pfam13365 128 SGGPVF 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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