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Conserved domains on  [gi|1985313549|ref|XP_039374278|]
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zinc finger protein 34-like [Mauremys reevesii]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 18089471)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB super family cl42959
krueppel associated box;
1-32 5.13e-13

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 63.38  E-value: 5.13e-13
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1985313549    1 MQENYKTVTSLGFPLPKPDLITRLEQGKEPWV 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
239-389 4.70e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 4.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985313549 239 PHKCLDCGKSFIQRSNLVTHQ--AIHTRE--RPHKC--LDCGKSFTWRSALVKHMAVHTGERPYKC--LDCGKSFT---- 306
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSplln 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985313549 307 -CRSALVRHLAIHTGERPHRCLD--CGKSFIQRSALVKHLAIHTSERPH--KCLDCGKSFIERSALVTHQAVHTRERPHK 381
Cdd:COG5048   369 nEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448


                  ....*...
gi 1985313549 382 CLDCGKSF 389
Cdd:COG5048   449 CSILKSFR 456
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
1-32 5.13e-13

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 63.38  E-value: 5.13e-13
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1985313549    1 MQENYKTVTSLGFPLPKPDLITRLEQGKEPWV 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
239-389 4.70e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 4.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985313549 239 PHKCLDCGKSFIQRSNLVTHQ--AIHTRE--RPHKC--LDCGKSFTWRSALVKHMAVHTGERPYKC--LDCGKSFT---- 306
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSplln 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985313549 307 -CRSALVRHLAIHTGERPHRCLD--CGKSFIQRSALVKHLAIHTSERPH--KCLDCGKSFIERSALVTHQAVHTRERPHK 381
Cdd:COG5048   369 nEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448


                  ....*...
gi 1985313549 382 CLDCGKSF 389
Cdd:COG5048   449 CSILKSFR 456
zf-H2C2_2 pfam13465
Zinc-finger double domain;
282-307 1.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.98e-04
                          10        20
                  ....*....|....*....|....*.
gi 1985313549 282 ALVKHMAVHTGERPYKCLDCGKSFTC 307
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
226-251 3.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 1985313549 226 ALVRHQAIHTGERPHKCLDCGKSFIQ 251
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
1-32 5.13e-13

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 63.38  E-value: 5.13e-13
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1985313549    1 MQENYKTVTSLGFPLPKPDLITRLEQGKEPWV 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
239-389 4.70e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 4.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985313549 239 PHKCLDCGKSFIQRSNLVTHQ--AIHTRE--RPHKC--LDCGKSFTWRSALVKHMAVHTGERPYKC--LDCGKSFT---- 306
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSplln 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985313549 307 -CRSALVRHLAIHTGERPHRCLD--CGKSFIQRSALVKHLAIHTSERPH--KCLDCGKSFIERSALVTHQAVHTRERPHK 381
Cdd:COG5048   369 nEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448


                  ....*...
gi 1985313549 382 CLDCGKSF 389
Cdd:COG5048   449 CSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
183-337 1.12e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985313549 183 PSQCLEGRNCLNWKSAPITHQKT--HTG--DRPYKC--LDCVKRFTCRSALVRHQAIHTGERPHKC--LDCGKSFIQRSN 254
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLN 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985313549 255 LVTHQAIHTRERPHK-----CLD--CGKSFTWRSALVKHMAVHTGERP--YKCLDCGKSFTCRSALVRHLAIHTGERPHR 325
Cdd:COG5048   369 NEPPQSLQQYKDLKNdkkseTLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                         170
                  ....*....|..
gi 1985313549 326 CLDCGKSFIQRS 337
Cdd:COG5048   449 CSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
282-307 1.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.98e-04
                          10        20
                  ....*....|....*....|....*.
gi 1985313549 282 ALVKHMAVHTGERPYKCLDCGKSFTC 307
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
226-251 3.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 1985313549 226 ALVRHQAIHTGERPHKCLDCGKSFIQ 251
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
310-335 4.01e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.01e-04
                          10        20
                  ....*....|....*....|....*.
gi 1985313549 310 ALVRHLAIHTGERPHRCLDCGKSFIQ 335
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
254-278 3.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.91e-03
                          10        20
                  ....*....|....*....|....*
gi 1985313549 254 NLVTHQAIHTRERPHKCLDCGKSFT 278
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
338-361 4.40e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.40e-03
                          10        20
                  ....*....|....*....|....
gi 1985313549 338 ALVKHLAIHTSERPHKCLDCGKSF 361
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-276 5.28e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 5.28e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985313549 209 DRPYKCLDCVKRFTCRSALVRHQAIHTGERPHKCLD--CGKSFIQRSNLVTHQAIHTRERPHKCLDCGKS 276
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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