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Conserved domains on  [gi|1988908324|ref|XP_039500825|]
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uncharacterized protein LOC120457362 isoform X2 [Drosophila santomea]

Protein Classification

F-box/LRR-repeat protein( domain architecture ID 1915047)

F-box protein functions as the substrate-recognition component of an SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation

CATH:  1.20.1280.50|3.80.10.10
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515|GO:0016567
PubMed:  31898225|11178263|11751054|14747988|10581972|7583641
SCOP:  4001927|4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_SF super family cl45894
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 791-826 1.52e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


The actual alignment was detected with superfamily member cd22149:

Pssm-ID: 459239  Cd Length: 43  Bit Score: 40.43  E-value: 1.52e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1988908324  791 QVLMGIMKTLNLKERAKMARVCKTWAMVSRDKSVWH 826
Cdd:cd22149      7 EIILSIFKWLPKKTLARCARVCRRWKRLCFDESLWR 42
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
874-984 1.53e-03

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 1.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988908324  874 LKALRVLTTGKVGAEFLTLVFRHLPQLLELRTICNsptlNLSTLghqSDELRVL----HIYLSDrrNKFESIHSLGNLKN 949
Cdd:COG4886    181 LTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN----QLTDL---PEPLANLtnleTLDLSN--NQLTDLPELGNLTN 251

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1988908324  950 LTELVIRGVHFlgaEDFQFLTKLSCLRLLVLSSCQ 984
Cdd:COG4886    252 LEELDLSNNQL---TDLPPLANLTNLKTLDLSNNQ 283
 
Name Accession Description Interval E-value
F-box_DmSKP2-like cd22149
F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and ...
 791-826 1.52e-04

F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438920  Cd Length: 43  Bit Score: 40.43  E-value: 1.52e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1988908324  791 QVLMGIMKTLNLKERAKMARVCKTWAMVSRDKSVWH 826
Cdd:cd22149      7 EIILSIFKWLPKKTLARCARVCRRWKRLCFDESLWR 42
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
874-984 1.53e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 1.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988908324  874 LKALRVLTTGKVGAEFLTLVFRHLPQLLELRTICNsptlNLSTLghqSDELRVL----HIYLSDrrNKFESIHSLGNLKN 949
Cdd:COG4886    181 LTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN----QLTDL---PEPLANLtnleTLDLSN--NQLTDLPELGNLTN 251

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1988908324  950 LTELVIRGVHFlgaEDFQFLTKLSCLRLLVLSSCQ 984
Cdd:COG4886    252 LEELDLSNNQL---TDLPPLANLTNLKTLDLSNNQ 283
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 792-829 2.55e-03

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 36.69  E-value: 2.55e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1988908324  792 VLMGIMKTLNLKERAKMARVCKTWAMVSRDKSVWHTVS 829
Cdd:pfam12937    8 ILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
FBOX smart00256
A Receptor for Ubiquitination Targets;
792-826 3.06e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 36.65  E-value: 3.06e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1988908324   792 VLMGIMKTLNLKERAKMARVCKTWAMVSRDKSVWH 826
Cdd:smart00256    5 ILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWF 39
 
Name Accession Description Interval E-value
F-box_DmSKP2-like cd22149
F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and ...
 791-826 1.52e-04

F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438920  Cd Length: 43  Bit Score: 40.43  E-value: 1.52e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1988908324  791 QVLMGIMKTLNLKERAKMARVCKTWAMVSRDKSVWH 826
Cdd:cd22149      7 EIILSIFKWLPKKTLARCARVCRRWKRLCFDESLWR 42
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
 792-825 8.71e-04

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 38.10  E-value: 8.71e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1988908324  792 VLMGIMKTLNLKERAKMARVCKTWAMVSRDKSVW 825
Cdd:cd22123      8 VLLEILSYLPVRDLLRISRVCKRWRRLVYDKTLW 41
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
874-984 1.53e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 1.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988908324  874 LKALRVLTTGKVGAEFLTLVFRHLPQLLELRTICNsptlNLSTLghqSDELRVL----HIYLSDrrNKFESIHSLGNLKN 949
Cdd:COG4886    181 LTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN----QLTDL---PEPLANLtnleTLDLSN--NQLTDLPELGNLTN 251

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1988908324  950 LTELVIRGVHFlgaEDFQFLTKLSCLRLLVLSSCQ 984
Cdd:COG4886    252 LEELDLSNNQL---TDLPPLANLTNLKTLDLSNNQ 283
F-box_JHDM cd22122
F-box domain found in the JmjC domain-containing histone demethylation protein (JHDM) family; ...
 791-827 1.82e-03

F-box domain found in the JmjC domain-containing histone demethylation protein (JHDM) family; The JHDM family includes F-box/LRR-repeat proteins FBXL10, FBXL11 and FBXL19. FBXL10 is also called lysine-specific demethylase 2B (KDM2B), CXXC-type zinc finger protein 2 (CXXC2), F-box and leucine-rich repeat protein 10 (FBL10), JmjC domain-containing histone demethylation protein 1B (JHDM1B), Jumonji domain-containing EMSY-interactor methyltransferase motif protein, protein JEMMA, protein-containing CXXC domain 2, [Histone-H3]-lysine-36 demethylase 1B, or NDY1. It is a histone demethylase that catalyzes the demethylation of H3K4me3 and H3K36me2, thereby playing a central role in the histone code. It preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. FBXL10 may also serve as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. FBXL11, also called KDM2A, CXXC8, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, JmjC domain-containing histone demethylation protein 1A (JHDM1A), or [Histone-H3]-lysine-36 demethylase 1A, is a histone H3 lysine 36 (H3K36) demethylase that regulates epithelial mesenchymal transition (EMT) and the metastasis of ovarian cancer. It plays an essential role in embryonic development and homeostasis by regulating cell proliferation and survival. FBXL11 may also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. It associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. It is required to sustain centromeric integrity and genomic stability, particularly during mitosis. FBXL19, also called F-box and leucine-rich repeat protein 19, is the substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It acts as a CpG island-binding protein in mouse embryonic stem (ES) cells and has been shown to associate with the CDK-Mediator complex. It promotes H2Bub1 at the promoters of CpG island-containing genes by interacting with RNF20. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438894  Cd Length: 43  Bit Score: 37.25  E-value: 1.82e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1988908324  791 QVLMGIMKTLNLKERAKMARVCKTWAMVSRDKSVWHT 827
Cdd:cd22122      7 EVWLPVFQYLSPKDLCVCMRVCKTWNRWCCDPSLWKR 43
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 792-829 2.55e-03

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 36.69  E-value: 2.55e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1988908324  792 VLMGIMKTLNLKERAKMARVCKTWAMVSRDKSVWHTVS 829
Cdd:pfam12937    8 ILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
FBOX smart00256
A Receptor for Ubiquitination Targets;
792-826 3.06e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 36.65  E-value: 3.06e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1988908324   792 VLMGIMKTLNLKERAKMARVCKTWAMVSRDKSVWH 826
Cdd:smart00256    5 ILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWF 39
F-box_AtADLO1-like cd22155
F-box domain found in Arabidopsis thaliana protein ARABIDILLO 1 (AtADLO1) and similar proteins; ...
 792-825 8.90e-03

F-box domain found in Arabidopsis thaliana protein ARABIDILLO 1 (AtADLO1) and similar proteins; AtADLO1, also called F-box only protein 5 (FBX5), promotes lateral root initiation and development, independently of auxin (IAA) and abscisic acid (ABA). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438926  Cd Length: 42  Bit Score: 35.23  E-value: 8.90e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1988908324  792 VLMGIMKTLNLKERAKMARVCKTWAMVSRDKSVW 825
Cdd:cd22155      9 TVLGLFGLLNYRDRASLASVCRAWRALGSSHSLW 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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