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Conserved domains on  [gi|1998646234|ref|XP_039770195|]
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uncharacterized protein LOC103168766 [Ornithorhynchus anatinus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12822048)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 384-466 2.27e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 65.43  E-value: 2.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1998646234 384 KKGVRCFDYCKPLSLLATGGSDCTVRLWNrYVPGWPTAILRGHSGAVLGVAILQIRDQLLSFSKDGVLKVWALGSSACLQ 463
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87


                  ...
gi 1998646234 464 TVR 466
Cdd:cd00200    88 TLT 90
WD40 COG2319
WD40 repeat [General function prediction only];
143-473 4.14e-09

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.54  E-value: 4.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1998646234 143 ADRPLQDPLLRRPPLIRRCPQNRQEPTTRVLALPHPPPLQFVSVSRGGVLSVWDSRFRLQKTYKIAAVVNDLTTERSQmk 222
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHT-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1998646234 223 AWITDAAYLPNVHKVAVATTGRKIHFLEMSPTSffEEFHLFGLNGIPTCLCYchkSEDGCSLLLWGDDhGGVnVLWflhp 302
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGL--LLRTLTGHTGAVRSVAF---SPDGKTLASGSAD-GTV-RLW---- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1998646234 303 lsglinksllerSGLSGIFMQDISEHSHflsyyYLSAVhpeAISqiqhlPEDQCITSSGSSETsVVIMDLWKKRTAYTWK 382
Cdd:COG2319   148 ------------DLATGKLLRTLTGHSG-----AVTSV---AFS-----PDGKLLASGSDDGT-VRLWDLATGKLLRTLT 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1998646234 383 I-KKGVRCFDYCKPLSLLATGGSDCTVRLWNRyVPGWPTAILRGHSGAVLGVAILQIRDQLLSFSKDGVLKVWALGSSAC 461
Cdd:COG2319   202 GhTGAVRSVAFSPDGKLLASGSADGTVRLWDL-ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL 280

                         330
                  ....*....|..
gi 1998646234 462 LQTVRLPLDRAR 473
Cdd:COG2319   281 LRTLTGHSGGVN 292
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 384-466 2.27e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.43  E-value: 2.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1998646234 384 KKGVRCFDYCKPLSLLATGGSDCTVRLWNrYVPGWPTAILRGHSGAVLGVAILQIRDQLLSFSKDGVLKVWALGSSACLQ 463
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87


                  ...
gi 1998646234 464 TVR 466
Cdd:cd00200    88 TLT 90
WD40 COG2319
WD40 repeat [General function prediction only];
398-466 1.75e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.70  E-value: 1.75e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1998646234 398 LLATGGSDCTVRLWNRyVPGWPTAILRGHSGAVLGVAILQIRDQLLSFSKDGVLKVWALGSSACLQTVR 466
Cdd:COG2319   260 LLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 327
WD40 COG2319
WD40 repeat [General function prediction only];
143-473 4.14e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.54  E-value: 4.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1998646234 143 ADRPLQDPLLRRPPLIRRCPQNRQEPTTRVLALPHPPPLQFVSVSRGGVLSVWDSRFRLQKTYKIAAVVNDLTTERSQmk 222
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHT-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1998646234 223 AWITDAAYLPNVHKVAVATTGRKIHFLEMSPTSffEEFHLFGLNGIPTCLCYchkSEDGCSLLLWGDDhGGVnVLWflhp 302
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGL--LLRTLTGHTGAVRSVAF---SPDGKTLASGSAD-GTV-RLW---- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1998646234 303 lsglinksllerSGLSGIFMQDISEHSHflsyyYLSAVhpeAISqiqhlPEDQCITSSGSSETsVVIMDLWKKRTAYTWK 382
Cdd:COG2319   148 ------------DLATGKLLRTLTGHSG-----AVTSV---AFS-----PDGKLLASGSDDGT-VRLWDLATGKLLRTLT 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1998646234 383 I-KKGVRCFDYCKPLSLLATGGSDCTVRLWNRyVPGWPTAILRGHSGAVLGVAILQIRDQLLSFSKDGVLKVWALGSSAC 461
Cdd:COG2319   202 GhTGAVRSVAFSPDGKLLASGSADGTVRLWDL-ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL 280

                         330
                  ....*....|..
gi 1998646234 462 LQTVRLPLDRAR 473
Cdd:COG2319   281 LRTLTGHSGGVN 292
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 416-454 5.06e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 5.06e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1998646234  416 PGWPTAILRGHSGAVLGVAILQIRDQLLSFSKDGVLKVW 454
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
417-454 7.25e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 7.25e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1998646234 417 GWPTAILRGHSGAVLGVAILQIRDQLLSFSKDGVLKVW 454
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 384-466 2.27e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.43  E-value: 2.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1998646234 384 KKGVRCFDYCKPLSLLATGGSDCTVRLWNrYVPGWPTAILRGHSGAVLGVAILQIRDQLLSFSKDGVLKVWALGSSACLQ 463
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87


                  ...
gi 1998646234 464 TVR 466
Cdd:cd00200    88 TLT 90
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 340-464 8.43e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.81  E-value: 8.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1998646234 340 VHPEAISQIQHLPEDQCITSSGSSETsVVIMDLWKKRTAYTWK-IKKGVRCFDYCKPLSLLATGGSDCTVRLWNRyVPGW 418
Cdd:cd00200    49 GHTGPVRDVAASADGTYLASGSSDKT-IRLWDLETGECVRTLTgHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGK 126

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1998646234 419 PTAILRGHSGAVLGVAILQIRDQLLSFSKDGVLKVWALGSSACLQT 464
Cdd:cd00200   127 CLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT 172
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 341-466 1.34e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.04  E-value: 1.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1998646234 341 HPEAISQIQHLPEDQcITSSGSSETSVVIMDLWKKRTAYTWKI-KKGVRCFDYCKPLSLLATGGSDCTVRLWNRYVpGWP 419
Cdd:cd00200   134 HTDWVNSVAFSPDGT-FVASSSQDGTIKLWDLRTGKCVATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST-GKC 211

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1998646234 420 TAILRGHSGAVLGVAILQIRDQLLSFSKDGVLKVWALGSSACLQTVR 466
Cdd:cd00200   212 LGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS 258
WD40 COG2319
WD40 repeat [General function prediction only];
398-466 1.75e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.70  E-value: 1.75e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1998646234 398 LLATGGSDCTVRLWNRyVPGWPTAILRGHSGAVLGVAILQIRDQLLSFSKDGVLKVWALGSSACLQTVR 466
Cdd:COG2319   260 LLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 327
WD40 COG2319
WD40 repeat [General function prediction only];
398-466 3.18e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.92  E-value: 3.18e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1998646234 398 LLATGGSDCTVRLWNRyVPGWPTAILRGHSGAVLGVAILQIRDQLLSFSKDGVLKVWALGSSACLQTVR 466
Cdd:COG2319   302 LLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369
WD40 COG2319
WD40 repeat [General function prediction only];
360-458 3.73e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.92  E-value: 3.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1998646234 360 SGSSETSVVIMDLWKKRTAYTWKIKKG-VRCFDYCKPLSLLATGGSDCTVRLWNRyVPGWPTAILRGHSGAVLGVAILQI 438
Cdd:COG2319   305 SGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSPDGKTLASGSDDGTVRLWDL-ATGELLRTLTGHTGAVTSVAFSPD 383

                          90       100
                  ....*....|....*....|
gi 1998646234 439 RDQLLSFSKDGVLKVWALGS 458
Cdd:COG2319   384 GRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
143-473 4.14e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.54  E-value: 4.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1998646234 143 ADRPLQDPLLRRPPLIRRCPQNRQEPTTRVLALPHPPPLQFVSVSRGGVLSVWDSRFRLQKTYKIAAVVNDLTTERSQmk 222
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHT-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1998646234 223 AWITDAAYLPNVHKVAVATTGRKIHFLEMSPTSffEEFHLFGLNGIPTCLCYchkSEDGCSLLLWGDDhGGVnVLWflhp 302
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGL--LLRTLTGHTGAVRSVAF---SPDGKTLASGSAD-GTV-RLW---- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1998646234 303 lsglinksllerSGLSGIFMQDISEHSHflsyyYLSAVhpeAISqiqhlPEDQCITSSGSSETsVVIMDLWKKRTAYTWK 382
Cdd:COG2319   148 ------------DLATGKLLRTLTGHSG-----AVTSV---AFS-----PDGKLLASGSDDGT-VRLWDLATGKLLRTLT 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1998646234 383 I-KKGVRCFDYCKPLSLLATGGSDCTVRLWNRyVPGWPTAILRGHSGAVLGVAILQIRDQLLSFSKDGVLKVWALGSSAC 461
Cdd:COG2319   202 GhTGAVRSVAFSPDGKLLASGSADGTVRLWDL-ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL 280

                         330
                  ....*....|..
gi 1998646234 462 LQTVRLPLDRAR 473
Cdd:COG2319   281 LRTLTGHSGGVN 292
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 341-466 9.56e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.73  E-value: 9.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1998646234 341 HPEAISQIQHLPEDQCITSsGSSETSVVIMDLWKKRTAYTWKI-KKGVRCFDYCKPLSLLATGGSDCTVRLWNrYVPGWP 419
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLAT-GSGDGTIKVWDLETGELLRTLKGhTGPVRDVAASADGTYLASGSSDKTIRLWD-LETGEC 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1998646234 420 TAILRGHSGAVLGVAILQIRDQLLSFSKDGVLKVWALGSSACLQTVR 466
Cdd:cd00200    86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR 132
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 360-455 1.25e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1998646234 360 SGSSETSVVIMDLWKKRTAYTWKIK-KGVRCFDYCKPLSLLATGGSDCTVRLWNrYVPGWPTAILRGHSGAVLGVAILQI 438
Cdd:cd00200   194 SSSSDGTIKLWDLSTGKCLGTLRGHeNGVNSVAFSPDGYLLASGSEDGTIRVWD-LRTGECVQTLSGHTNSVTSLAWSPD 272

                          90
                  ....*....|....*..
gi 1998646234 439 RDQLLSFSKDGVLKVWA 455
Cdd:cd00200   273 GKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 416-454 5.06e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 5.06e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1998646234  416 PGWPTAILRGHSGAVLGVAILQIRDQLLSFSKDGVLKVW 454
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 384-412 4.00e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 4.00e-03
                           10        20
                   ....*....|....*....|....*....
gi 1998646234  384 KKGVRCFDYCKPLSLLATGGSDCTVRLWN 412
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
417-454 7.25e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 7.25e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1998646234 417 GWPTAILRGHSGAVLGVAILQIRDQLLSFSKDGVLKVW 454
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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