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Conserved domains on  [gi|2019517303|ref|XP_040282695|]
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ribosomal RNA-processing protein 8 [Bufo bufo]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 279-491 1.64e-98

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam05148:

Pssm-ID: 473071  Cd Length: 214  Bit Score: 295.57  E-value: 1.64e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303 279 MEQRLKSARFRYINQQLYTSDSQEALNLFQQDPDAFSCYHTGFSQQVQRWPVNPITEIIKYIKNRPSSLVVADFGCGDAL 358
Cdd:pfam05148   1 MKKRLDGGRFRMLNEKLYTGKGSRAGDLFKEDPDAFDLYHEGFNLQVKKWPVNPLDVIIRKLKRRPGNGVIADLGCGEAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303 359 LARSVRN--KVHSFDLVALNDHVTVCDMAKVPLAGSSVDVAVFCLSLMGKNLSDFLQEANRILKPGGVLLVAEVSSRFDD 436
Cdd:pfam05148  81 IAFRKREfeNVHSFDLVAVNKRVIPCDMARVPLEDESVDVAVFCLSLMGTNIADFLKEANRILKNGGLLKIAEVRSRFPS 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2019517303 437 IRPFLNAMSQLGFKSINKNTENSYFFLFEFSKTGgaRDASKH-PGLQLKPCLYKKR 491
Cdd:pfam05148 161 VGLFERAFTKLGFEVEHVDLSNAQFVLFEFQKTS--RVGPKRlLGLKLVPCLYKKR 214
PTZ00121 super family cl31754
MAEBL; Provisional
 19-286 1.03e-03

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.05  E-value: 1.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303   19 AENEEKSSAQEKGTSSRKK--------RLKRNRQLQQVLRSLNTPSTLYPDLPPAPDTTSVKRRKKPAPGKTGIEGHLPE 90
Cdd:PTZ00121  1220 AEDAKKAEAVKKAEEAKKDaeeakkaeEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAE 1299

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303   91 VDPRAEEPPQSAEKLSRRQwrnKLKnKKKSRNKFKVDSGTSGQRTAENRDTARDPGAGATAAPGEAPPKQGdRKTKSQKS 170
Cdd:PTZ00121  1300 EKKKADEAKKKAEEAKKAD---EAK-KKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKA-EAAEKKKE 1374

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303  171 QGKQNGNVLVDRAEQTQPP---PGSSAWKRPKAEHLR-AAEPRTSASGARVTPQERARLKKLKKVMQ-----CQAGSKAP 241
Cdd:PTZ00121  1375 EAKKKADAAKKKAEEKKKAdeaKKKAEEDKKKADELKkAAAAKKKADEAKKKAEEKKKADEAKKKAEeakkaDEAKKKAE 1454

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 2019517303  242 EIASEEDPQKAFKEAEQPPEADNSDARQDRSAELRARMEQRLKSA 286
Cdd:PTZ00121  1455 EAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKA 1499
 
Name Accession Description Interval E-value
Methyltransf_8 pfam05148
Hypothetical methyltransferase; This family consists of several uncharacterized eukaryotic ...
 279-491 1.64e-98

Hypothetical methyltransferase; This family consists of several uncharacterized eukaryotic proteins which are related to methyltransferases pfam01209.


Pssm-ID: 398698  Cd Length: 214  Bit Score: 295.57  E-value: 1.64e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303 279 MEQRLKSARFRYINQQLYTSDSQEALNLFQQDPDAFSCYHTGFSQQVQRWPVNPITEIIKYIKNRPSSLVVADFGCGDAL 358
Cdd:pfam05148   1 MKKRLDGGRFRMLNEKLYTGKGSRAGDLFKEDPDAFDLYHEGFNLQVKKWPVNPLDVIIRKLKRRPGNGVIADLGCGEAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303 359 LARSVRN--KVHSFDLVALNDHVTVCDMAKVPLAGSSVDVAVFCLSLMGKNLSDFLQEANRILKPGGVLLVAEVSSRFDD 436
Cdd:pfam05148  81 IAFRKREfeNVHSFDLVAVNKRVIPCDMARVPLEDESVDVAVFCLSLMGTNIADFLKEANRILKNGGLLKIAEVRSRFPS 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2019517303 437 IRPFLNAMSQLGFKSINKNTENSYFFLFEFSKTGgaRDASKH-PGLQLKPCLYKKR 491
Cdd:pfam05148 161 VGLFERAFTKLGFEVEHVDLSNAQFVLFEFQKTS--RVGPKRlLGLKLVPCLYKKR 214
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 335-450 7.97e-14

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 68.48  E-value: 7.97e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303 335 EIIKYIKNRPSSlVVADFGCGDALLARSVRN---KVHSFDLVA--------------LNDHVTVCDMAKVPLAGSSVDVA 397
Cdd:COG2226    13 ALLAALGLRPGA-RVLDLGCGTGRLALALAErgaRVTGVDISPemlelareraaeagLNVEFVVGDAEDLPFPDGSFDLV 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2019517303 398 VFCLSLMgkNLSD---FLQEANRILKPGGVLLVAEVSSrfDDIRPFLNAMSQLGFK 450
Cdd:COG2226    92 ISSFVLH--HLPDperALAEIARVLKPGGRLVVVDFSP--PDLAELEELLAEAGFE 143
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 349-427 1.77e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 43.57  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303 349 VADFGCGD----ALLARSVRNKVHSFDL---------------VALNDHVTVCDMAKVPL-AGSSVDVAVFCLSLMG--K 406
Cdd:cd02440     2 VLDLGCGTgalaLALASGPGARVTGVDIspvalelarkaaaalLADNVEVLKGDAEELPPeADESFDVIISDPPLHHlvE 81

                          90       100
                  ....*....|....*....|.
gi 2019517303 407 NLSDFLQEANRILKPGGVLLV 427
Cdd:cd02440    82 DLARFLEEARRLLKPGGVLVL 102
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 336-460 6.02e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 41.29  E-value: 6.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303 336 IIKYIK--NRPSSLVVADFGCGdaLLArsV-RNKVHSFDLVAlNDHVTVCDMAKVPLAGSSVDVAV--FCLslmgKNLSD 410
Cdd:PRK00216   66 AIALAKavGKTGEVVGLDFSEG--MLA--VgREKLRDLGLSG-NVEFVQGDAEALPFPDNSFDAVTiaFGL----RNVPD 136

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2019517303 411 F---LQEANRILKPGGVLLVAEVSSR----FDDIRPF--LNAMSQLGfKSINKNTEnSY 460
Cdd:PRK00216  137 IdkaLREMYRVLKPGGRLVILEFSKPtnppLKKAYDFylFKVLPLIG-KLISKNAE-AY 193
PTZ00121 PTZ00121
MAEBL; Provisional
 19-286 1.03e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.05  E-value: 1.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303   19 AENEEKSSAQEKGTSSRKK--------RLKRNRQLQQVLRSLNTPSTLYPDLPPAPDTTSVKRRKKPAPGKTGIEGHLPE 90
Cdd:PTZ00121  1220 AEDAKKAEAVKKAEEAKKDaeeakkaeEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAE 1299

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303   91 VDPRAEEPPQSAEKLSRRQwrnKLKnKKKSRNKFKVDSGTSGQRTAENRDTARDPGAGATAAPGEAPPKQGdRKTKSQKS 170
Cdd:PTZ00121  1300 EKKKADEAKKKAEEAKKAD---EAK-KKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKA-EAAEKKKE 1374

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303  171 QGKQNGNVLVDRAEQTQPP---PGSSAWKRPKAEHLR-AAEPRTSASGARVTPQERARLKKLKKVMQ-----CQAGSKAP 241
Cdd:PTZ00121  1375 EAKKKADAAKKKAEEKKKAdeaKKKAEEDKKKADELKkAAAAKKKADEAKKKAEEKKKADEAKKKAEeakkaDEAKKKAE 1454

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 2019517303  242 EIASEEDPQKAFKEAEQPPEADNSDARQDRSAELRARMEQRLKSA 286
Cdd:PTZ00121  1455 EAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKA 1499
 
Name Accession Description Interval E-value
Methyltransf_8 pfam05148
Hypothetical methyltransferase; This family consists of several uncharacterized eukaryotic ...
 279-491 1.64e-98

Hypothetical methyltransferase; This family consists of several uncharacterized eukaryotic proteins which are related to methyltransferases pfam01209.


Pssm-ID: 398698  Cd Length: 214  Bit Score: 295.57  E-value: 1.64e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303 279 MEQRLKSARFRYINQQLYTSDSQEALNLFQQDPDAFSCYHTGFSQQVQRWPVNPITEIIKYIKNRPSSLVVADFGCGDAL 358
Cdd:pfam05148   1 MKKRLDGGRFRMLNEKLYTGKGSRAGDLFKEDPDAFDLYHEGFNLQVKKWPVNPLDVIIRKLKRRPGNGVIADLGCGEAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303 359 LARSVRN--KVHSFDLVALNDHVTVCDMAKVPLAGSSVDVAVFCLSLMGKNLSDFLQEANRILKPGGVLLVAEVSSRFDD 436
Cdd:pfam05148  81 IAFRKREfeNVHSFDLVAVNKRVIPCDMARVPLEDESVDVAVFCLSLMGTNIADFLKEANRILKNGGLLKIAEVRSRFPS 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2019517303 437 IRPFLNAMSQLGFKSINKNTENSYFFLFEFSKTGgaRDASKH-PGLQLKPCLYKKR 491
Cdd:pfam05148 161 VGLFERAFTKLGFEVEHVDLSNAQFVLFEFQKTS--RVGPKRlLGLKLVPCLYKKR 214
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 335-450 7.97e-14

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 68.48  E-value: 7.97e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303 335 EIIKYIKNRPSSlVVADFGCGDALLARSVRN---KVHSFDLVA--------------LNDHVTVCDMAKVPLAGSSVDVA 397
Cdd:COG2226    13 ALLAALGLRPGA-RVLDLGCGTGRLALALAErgaRVTGVDISPemlelareraaeagLNVEFVVGDAEDLPFPDGSFDLV 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2019517303 398 VFCLSLMgkNLSD---FLQEANRILKPGGVLLVAEVSSrfDDIRPFLNAMSQLGFK 450
Cdd:COG2226    92 ISSFVLH--HLPDperALAEIARVLKPGGRLVVVDFSP--PDLAELEELLAEAGFE 143
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 349-423 1.23e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 55.26  E-value: 1.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303 349 VADFGCGD----ALLARSVRNKVHSFDLVA--------------LNDHVTVCDMAKVPLAGSSVDVAVFCLSLM---GKN 407
Cdd:pfam13649   1 VLDLGCGTgrltLALARRGGARVTGVDLSPemlerareraaeagLNVEFVQGDAEDLPFPDGSFDLVVSSGVLHhlpDPD 80

                          90
                  ....*....|....*.
gi 2019517303 408 LSDFLQEANRILKPGG 423
Cdd:pfam13649  81 LEAALREIARVLKPGG 96
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 351-427 6.91e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 53.05  E-value: 6.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303 351 DFGCGDALLARSVRN---KVHSFDL------------VALNDHVTVCDMAKVPLAGSSVDVAVFCLSLMG-KNLSDFLQE 414
Cdd:pfam08241   2 DVGCGTGLLTELLARlgaRVTGVDIspemlelarekaPREGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHvEDPERALRE 81

                          90
                  ....*....|...
gi 2019517303 415 ANRILKPGGVLLV 427
Cdd:pfam08241  82 IARVLKPGGILII 94
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
327-426 2.69e-08

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 53.46  E-value: 2.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303 327 RWPVNPITEIIKYIKNRPSSLVVaDFGCGDALLARSVRNK---VHSFDL------VA----LNDHVTVCDMAKVPLAGSS 393
Cdd:COG4976    29 EAPALLAEELLARLPPGPFGRVL-DLGCGTGLLGEALRPRgyrLTGVDLseemlaKArekgVYDRLLVADLADLAEPDGR 107

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2019517303 394 VDVAVFCLSLM-GKNLSDFLQEANRILKPGGVLL 426
Cdd:COG4976   108 FDLIVAADVLTyLGDLAAVFAGVARALKPGGLFI 141
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 334-428 1.42e-07

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 50.02  E-value: 1.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303 334 TEIIKYIKNR-PSSLVVADFGCGDALLARSVRN---KVHSFDL------------VALNDHVTVCDMAKVPLAGSSVDVa 397
Cdd:COG2227    12 RRLAALLARLlPAGGRVLDVGCGTGRLALALARrgaDVTGVDIspealeiareraAELNVDFVQGDLEDLPLEDGSFDL- 90

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2019517303 398 VFCLSLMG--KNLSDFLQEANRILKPGGVLLVA 428
Cdd:COG2227    91 VICSEVLEhlPDPAALLRELARLLKPGGLLLLS 123
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 337-427 5.48e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 47.22  E-value: 5.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303 337 IKYIKNRPSSLVVADFGCGDALLARSVRNKVHS------FDLVALN-----------DHVT--VCDMAK-VPLAGSSVDV 396
Cdd:COG0500    18 LALLERLPKGGRVLDLGCGTGRNLLALAARFGGrvigidLSPEAIAlararaakaglGNVEflVADLAElDPLPAESFDL 97

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2019517303 397 AVF--CLSLMGK-NLSDFLQEANRILKPGGVLLV 427
Cdd:COG0500    98 VVAfgVLHHLPPeEREALLRELARALKPGGVLLL 131
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
343-465 1.28e-05

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 45.24  E-value: 1.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303 343 RPSSLVVaDFGCGDALLARSVRnkvhsFDLVALNDHVTVCDMAK-VPLAGSSVDvAVFC------LSLMgkNLSDFLQEA 415
Cdd:COG4627     1 SLSPLKL-NIGCGPKRLPGWLN-----VDIVPAPGVDIVGDLTDpLPFPDNSVD-AIYSshvlehLDYE--EAPLALKEC 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2019517303 416 NRILKPGGVLLVAeVSSRFDDIRPFLNAMSQLGFKSINKNTENSYFFLFE 465
Cdd:COG4627    72 YRVLKPGGILRIV-VPDLEHVARLYLAEYDAALDVAELRLAGPIDPLGII 120
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 349-427 1.77e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 43.57  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303 349 VADFGCGD----ALLARSVRNKVHSFDL---------------VALNDHVTVCDMAKVPL-AGSSVDVAVFCLSLMG--K 406
Cdd:cd02440     2 VLDLGCGTgalaLALASGPGARVTGVDIspvalelarkaaaalLADNVEVLKGDAEELPPeADESFDVIISDPPLHHlvE 81

                          90       100
                  ....*....|....*....|.
gi 2019517303 407 NLSDFLQEANRILKPGGVLLV 427
Cdd:cd02440    82 DLARFLEEARRLLKPGGVLVL 102
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 349-427 3.86e-05

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 43.76  E-value: 3.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303 349 VADFGCG---DAL-LARSVRNKVHSFDLVA--------------LNDHVTV--CDMAKVPLAGSsVD--VAVFCLSLMG- 405
Cdd:COG2230    55 VLDIGCGwggLALyLARRYGVRVTGVTLSPeqleyareraaeagLADRVEVrlADYRDLPADGQ-FDaiVSIGMFEHVGp 133

                          90       100
                  ....*....|....*....|..
gi 2019517303 406 KNLSDFLQEANRILKPGGVLLV 427
Cdd:COG2230   134 ENYPAYFAKVARLLKPGGRLLL 155
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 336-460 6.02e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 41.29  E-value: 6.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303 336 IIKYIK--NRPSSLVVADFGCGdaLLArsV-RNKVHSFDLVAlNDHVTVCDMAKVPLAGSSVDVAV--FCLslmgKNLSD 410
Cdd:PRK00216   66 AIALAKavGKTGEVVGLDFSEG--MLA--VgREKLRDLGLSG-NVEFVQGDAEALPFPDNSFDAVTiaFGL----RNVPD 136

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2019517303 411 F---LQEANRILKPGGVLLVAEVSSR----FDDIRPF--LNAMSQLGfKSINKNTEnSY 460
Cdd:PRK00216  137 IdkaLREMYRVLKPGGRLVILEFSKPtnppLKKAYDFylFKVLPLIG-KLISKNAE-AY 193
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 342-442 6.56e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 40.49  E-value: 6.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303 342 NRPSSLVVADFGCGDALLARSVRN---KVHSFD---------LVALNDHVTVCDMAKVPLAGSSVDVAVFCL-SLmgKNL 408
Cdd:pfam13489  19 KLPSPGRVLDFGCGTGIFLRLLRAqgfSVTGVDpspiaieraLLNVRFDQFDEQEAAVPAGKFDVIVAREVLeHV--PDP 96

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2019517303 409 SDFLQEANRILKPGGVLLVAEVSSRFDDIRPFLN 442
Cdd:pfam13489  97 PALLRQIAALLKPGGLLLLSTPLASDEADRLLLE 130
PTZ00121 PTZ00121
MAEBL; Provisional
 19-286 1.03e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.05  E-value: 1.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303   19 AENEEKSSAQEKGTSSRKK--------RLKRNRQLQQVLRSLNTPSTLYPDLPPAPDTTSVKRRKKPAPGKTGIEGHLPE 90
Cdd:PTZ00121  1220 AEDAKKAEAVKKAEEAKKDaeeakkaeEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAE 1299

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303   91 VDPRAEEPPQSAEKLSRRQwrnKLKnKKKSRNKFKVDSGTSGQRTAENRDTARDPGAGATAAPGEAPPKQGdRKTKSQKS 170
Cdd:PTZ00121  1300 EKKKADEAKKKAEEAKKAD---EAK-KKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKA-EAAEKKKE 1374

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303  171 QGKQNGNVLVDRAEQTQPP---PGSSAWKRPKAEHLR-AAEPRTSASGARVTPQERARLKKLKKVMQ-----CQAGSKAP 241
Cdd:PTZ00121  1375 EAKKKADAAKKKAEEKKKAdeaKKKAEEDKKKADELKkAAAAKKKADEAKKKAEEKKKADEAKKKAEeakkaDEAKKKAE 1454

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 2019517303  242 EIASEEDPQKAFKEAEQPPEADNSDARQDRSAELRARMEQRLKSA 286
Cdd:PTZ00121  1455 EAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKA 1499
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
349-429 2.08e-03

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 37.50  E-value: 2.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303 349 VADFGCGDALLARSVRNKVHSFDLVAL---------------NDHVTVCDMAKVPLAGSsVDVAVFCLSLM-GKNLSDFL 412
Cdd:COG4106     5 VLDLGCGTGRLTALLAERFPGARVTGVdlspemlarararlpNVRFVVADLRDLDPPEP-FDLVVSNAALHwLPDHAALL 83

                          90
                  ....*....|....*..
gi 2019517303 413 QEANRILKPGGVLLVAE 429
Cdd:COG4106    84 ARLAAALAPGGVLAVQV 100
PTZ00121 PTZ00121
MAEBL; Provisional
 19-284 4.55e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 4.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303   19 AENEEKSSAQEKGTSSRKKRLKRNRQLQQVLRSLNTPSTLYPDLPPAPDTTSVKRRKKPAPGKTGIEghlpEVDPRAEEP 98
Cdd:PTZ00121  1420 ADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKAD----EAKKKAEEA 1495

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303   99 PQSAEKLSRR-QWRNKLKNKKKSRNKFKVDSGTSGQ--RTAENRDTARDPGAGATAAPGEAPPKQGDRKTKSQKSQGKQN 175
Cdd:PTZ00121  1496 KKKADEAKKAaEAKKKADEAKKAEEAKKADEAKKAEeaKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEED 1575

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019517303  176 GNVLVDRAEQ---------TQPPPGSSAWKRPKAEHLRAAE-PRTSASGARVTPQERARL--------------KKLKKV 231
Cdd:PTZ00121  1576 KNMALRKAEEakkaeeariEEVMKLYEEEKKMKAEEAKKAEeAKIKAEELKKAEEEKKKVeqlkkkeaeekkkaEELKKA 1655

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2019517303  232 MQCQAGSKAPEIASEEDPQKAFKEAEQPPEADNSDARQDRSAELRARMEQRLK 284
Cdd:PTZ00121  1656 EEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELK 1708
PRK14968 PRK14968
putative methyltransferase; Provisional
 408-462 7.61e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 37.57  E-value: 7.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2019517303 408 LSDFLQEANRILKPGGVLLVaeVSSRFDDIRPFLNAMSQLGFKsINKNTENSYFF 462
Cdd:PRK14968  127 IDRFLDEVGRYLKPGGRILL--LQSSLTGEDEVLEYLEKLGFE-AEVVAEEKFPF 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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