Ca_chan_IQ domain-containing protein; Ca_chan_IQ domain-containing protein; voltage-dependent L-type (Long-lasting) calcium channel subunit alpha-1 is part of a multisubunit voltage-dependent calcium channel that mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death; voltage-dependent L-type (Long-lasting) calcium channel subunit alpha-1 is part of a multisubunit voltage-dependent calcium channel that mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
120-412
1.38e-68
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 231.39 E-value: 1.38e-68
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1202-1496
5.23e-61
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 209.43 E-value: 5.23e-61
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1907-2181
7.87e-59
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.
The actual alignment was detected with superfamily member pfam16885:
Pssm-ID: 465298 [Multi-domain] Cd Length: 355 Bit Score: 207.94 E-value: 7.87e-59
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
880-1157
2.18e-53
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 187.47 E-value: 2.18e-53
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
520-755
3.70e-51
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 181.31 E-value: 3.70e-51
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1568-1642
2.64e-37
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).
:
Pssm-ID: 462591 Cd Length: 77 Bit Score: 135.41 E-value: 2.64e-37
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1505-1558
7.01e-31
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.
:
Pssm-ID: 465306 Cd Length: 54 Bit Score: 116.21 E-value: 7.01e-31
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
120-412
1.38e-68
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 231.39 E-value: 1.38e-68
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1202-1496
5.23e-61
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 209.43 E-value: 5.23e-61
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1907-2181
7.87e-59
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.
Pssm-ID: 465298 [Multi-domain] Cd Length: 355 Bit Score: 207.94 E-value: 7.87e-59
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
880-1157
2.18e-53
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 187.47 E-value: 2.18e-53
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
520-755
3.70e-51
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 181.31 E-value: 3.70e-51
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1568-1642
2.64e-37
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).
Pssm-ID: 462591 Cd Length: 77 Bit Score: 135.41 E-value: 2.64e-37
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1505-1558
7.01e-31
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.
Pssm-ID: 465306 Cd Length: 54 Bit Score: 116.21 E-value: 7.01e-31
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1620-1650
1.64e-13
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).
Pssm-ID: 198130 Cd Length: 31 Bit Score: 66.09 E-value: 1.64e-13
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
120-412
1.38e-68
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 231.39 E-value: 1.38e-68
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1202-1496
5.23e-61
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 209.43 E-value: 5.23e-61
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1907-2181
7.87e-59
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.
Pssm-ID: 465298 [Multi-domain] Cd Length: 355 Bit Score: 207.94 E-value: 7.87e-59
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
880-1157
2.18e-53
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 187.47 E-value: 2.18e-53
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
520-755
3.70e-51
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 181.31 E-value: 3.70e-51
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1568-1642
2.64e-37
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).
Pssm-ID: 462591 Cd Length: 77 Bit Score: 135.41 E-value: 2.64e-37
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1505-1558
7.01e-31
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.
Pssm-ID: 465306 Cd Length: 54 Bit Score: 116.21 E-value: 7.01e-31
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1620-1650
1.64e-13
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).
Pssm-ID: 198130 Cd Length: 31 Bit Score: 66.09 E-value: 1.64e-13
Polycystin cation channel; This family contains the cation channel region from group II of ...
1238-1489
6.02e-08
Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.
Pssm-ID: 462341 [Multi-domain] Cd Length: 225 Bit Score: 55.75 E-value: 6.02e-08
Polycystin cation channel; This family contains the cation channel region from group II of ...
163-400
5.15e-03
Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.
Pssm-ID: 462341 [Multi-domain] Cd Length: 225 Bit Score: 40.72 E-value: 5.15e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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