|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
378-554 |
3.56e-117 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 361.08 E-value: 3.56e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 378 LPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLQGSPNAVANIICTQPRRISAISVAERVAKERTERVGV 457
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPVANIICTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 458 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRPDLRIILMSATL 537
Cdd:cd17985 81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSATL 160
|
170
....*....|....*..
gi 2024491165 538 NAELFSQYFHSCPIINI 554
Cdd:cd17985 161 NAELFSDYFNSCPVIHI 177
|
|
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
378-1003 |
2.04e-115 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 379.81 E-value: 2.04e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 378 LPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASL--QGSpnavanIICTQPRRISAISVAERVAKERTERV 455
Cdd:COG1643 10 LPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWgaGGR------IGMLEPRRLAARAAAERMAEELGEPV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 456 GVTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIM-VQRPDLRIILMS 534
Cdd:COG1643 84 GETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALRPDLKLLVMS 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 535 ATLNAELFSQYFHSCPIINIPGRTFPVDqffledviamTRYvLEDSSPYRRktkqenkvtarhkrtafeeveedlrhagl 614
Cdd:COG1643 164 ATLDAERFARLLGDAPVIESSGRTYPVE----------VRY-RPLPADERD----------------------------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 615 LEDtdtavkdsdpdqkltlkqllkrykGVNKTVLktmsvmdldkvnleliEALLEwivdgkhsyPPGAVLIFLPGLAEIK 694
Cdd:COG1643 204 LED------------------------AVADAVR----------------EALAE---------EPGDILVFLPGEREIR 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 695 MLYEQLQsnalfnNRHSKRCVVYPLHSSLSSEEQQSVFLRPPAGVIKIIISTNIAETSVTIDDVVYVIDSGKMKEKRYDP 774
Cdd:COG1643 235 RTAEALR------GRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDP 308
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 775 SKGMESLEDTFVSRANALQRKGRAGRVASGVCFHLFSSHHYNhQLIKQQLPEIQRVPLEQLCLRIKILEMFSAQSLhsvl 854
Cdd:COG1643 309 RSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFA-RRPAFTDPEILRADLASLILELAAWGLGDPEDL---- 383
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 855 sRLIEPPRTESLRASKLRLQDLGALTADEKLTPLGYHLASLPVDVRIGKLMLFGTIFRCLDPALTIAASLAFKSPFvspw 934
Cdd:COG1643 384 -PFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR---- 458
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024491165 935 dkREEAnkkkldfavgNSDYLALLQAykgWRlstkegsqaSYNYCRENFLSGRVLQEIASLKRQFTELL 1003
Cdd:COG1643 459 --RGAA----------GSDLLARLNL---WR---------RLREQQREFLSYLRLREWRDLARQLRRLL 503
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
376-1132 |
6.41e-89 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 314.40 E-value: 6.41e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 376 QKLPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLqGSPNAVANiicTQPRRISAISVAERVAKERTERV 455
Cdd:TIGR01967 64 DNLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGR-GSHGLIGH---TQPRRLAARTVAQRIAEELGTPL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 456 GVTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRPDLRIILMSA 535
Cdd:TIGR01967 140 GEKVGYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKIIITSA 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 536 TLNAELFSQYFHSCPIINIPGRTFPVDqffledviamTRYvledsspyrrktkqenkvtarhkRTAFEEVEEDlrhagll 615
Cdd:TIGR01967 220 TIDPERFSRHFNNAPIIEVSGRTYPVE----------VRY-----------------------RPLVEEQEDD------- 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 616 edtdtavkDSDPDQKLtlkqllkrykgvnktvlktmsvmdLDKVNlELIEALlewivdgkhsypPGAVLIFLPGLAEIKM 695
Cdd:TIGR01967 260 --------DLDQLEAI------------------------LDAVD-ELFAEG------------PGDILIFLPGEREIRD 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 696 LYEQLqsnalfNNRHSKRCVVYPLHSSLSSEEQQSVFlRPPAGViKIIISTNIAETSVTIDDVVYVIDSGKMKEKRYDPS 775
Cdd:TIGR01967 295 AAEIL------RKRNLRHTEILPLYARLSNKEQQRVF-QPHSGR-RIVLATNVAETSLTVPGIHYVIDTGTARISRYSYR 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 776 KGMESLEDTFVSRANALQRKGRAGRVASGVCFHLFSSHHYNHQLIKQQlPEIQRVPLEQLCLRIKILEMFSAQSLhsvls 855
Cdd:TIGR01967 367 TKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPEFTD-PEILRTNLASVILQMLALRLGDIAAF----- 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 856 RLIEPPRTESLRASKLRLQDLGALTADE---KLTPLGYHLASLPVDVRIGKLMLFGTIFRCLDPALTIAASLAFKSPFVS 932
Cdd:TIGR01967 441 PFIEAPDPRAIRDGFRLLEELGALDDDEaepQLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRER 520
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 933 PWDKREEANKKKLDFAVGNSDYLALLQAYKGWRLSTKEGSQASY-NYCRENFLSGRVLQEIASLKRQFTELLSDIGfvke 1011
Cdd:TIGR01967 521 PMEKQQAADQAHARFKDPRSDFLSRVNLWRHIEEQRQALSANQFrNACRKQYLNYLRVREWQDIYRQLTQVVKELG---- 596
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 1012 glrardierkWSqggdgvldatgeeANSNAENFKLISAMLCAALYPNVVQvKKPEGKYQktstgavkmqpKAEELKFvtk 1091
Cdd:TIGR01967 597 ----------LK-------------LNEEPADYDAIHKALLSGLLSQIGM-KDEKHEYD-----------GARGRKF--- 638
|
730 740 750 760
....*....|....*....|....*....|....*....|.
gi 2024491165 1092 ndgyvHIHPSSVNYQTRhfeSPYLVYHEKIKTSRVFIRDCS 1132
Cdd:TIGR01967 639 -----HIFPGSPLFKKP---PKWVMAAELVETSKLYARLVA 671
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
378-985 |
5.19e-76 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 275.79 E-value: 5.19e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 378 LPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLqgspnAVANIIC-TQPRRISAISVAERVAKERTERVG 456
Cdd:PRK11131 73 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGR-----GVKGLIGhTQPRRLAARTVANRIAEELETELG 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 457 VTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRPDLRIILMSAT 536
Cdd:PRK11131 148 GCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSAT 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 537 LNAELFSQYFHSCPIINIPGRTFPVDqffledviamTRYvledsSPyrrktkqenkvtarhkrtafeeveedlrhagLLE 616
Cdd:PRK11131 228 IDPERFSRHFNNAPIIEVSGRTYPVE----------VRY-----RP-------------------------------IVE 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 617 DTDtavkDSDPDQkltlkqllkrykgvnktvlktmsvmdldkvnlelIEALLEwIVDGKHSYPPGAVLIFLPGLAEIKML 696
Cdd:PRK11131 262 EAD----DTERDQ----------------------------------LQAIFD-AVDELGREGPGDILIFMSGEREIRDT 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 697 YEQLQSNALfnnRHSKrcvVYPLHSSLSSEEQQSVFlrPPAGVIKIIISTNIAETSVTIDDVVYVIDSGKMKEKRYDPSK 776
Cdd:PRK11131 303 ADALNKLNL---RHTE---ILPLYARLSNSEQNRVF--QSHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRT 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 777 GMESLEDTFVSRANALQRKGRAGRVASGVCFHLFSSHHYNHqliKQQL--PEIQRVPLEQLclrikILEMfSAQSLHSVL 854
Cdd:PRK11131 375 KVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLS---RPEFtdPEILRTNLASV-----ILQM-TALGLGDIA 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 855 S-RLIEPPRTESLRASKLRLQDLGALTADE-----KLTPLGYHLASLPVDVRIGKLMLFGTIFRCLDPALTIAASLAFKS 928
Cdd:PRK11131 446 AfPFVEAPDKRNIQDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQD 525
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*...
gi 2024491165 929 PFVSPWDKREEANKKKLDFAVGNSDYLALLQAYKGWRLSTKEGSQASY-NYCRENFLS 985
Cdd:PRK11131 526 PRERPMDKQQASDEKHRRFADKESDFLAFVNLWNYLQEQQKALSSNQFrRLCRTDYLN 583
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
651-810 |
2.51e-66 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 221.25 E-value: 2.51e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 651 MSVMDLDKVNLELIEALLEWIVdgkHSYPPGAVLIFLPGLAEIKMLYEQLQSNALFNNRHskRCVVYPLHSSLSSEEQQS 730
Cdd:cd18791 17 ISSEKEDPDYVDAAVRLILQIH---RTEEPGDILVFLPGQEEIERLCELLREELLSPDLG--KLLVLPLHSSLPPEEQQR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 731 VFLRPPAGVIKIIISTNIAETSVTIDDVVYVIDSGKMKEKRYDPSKGMESLEDTFVSRANALQRKGRAGRVASGVCFHLF 810
Cdd:cd18791 92 VFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
|
|
| RWD_DHX57 |
cd23825 |
RWD domain of DEAH box protein 57 (DHX57) and related proteins; DHX57 (EC 3.6.4.13) is a ... |
80-264 |
1.07e-47 |
|
RWD domain of DEAH box protein 57 (DHX57) and related proteins; DHX57 (EC 3.6.4.13) is a putative ATP-dependent RNA helicase. A genome-wide association study (GWAS) of cerebellar epigenetic age acceleration identified significant SNPs (single nucleotide polymorphisms) in a loci 2p22.1 inside the DHX57 gene, suggesting that variants in DHX57 are associated with epigenetic age in the cerebellum.
Pssm-ID: 467661 Cd Length: 115 Bit Score: 165.83 E-value: 1.07e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 80 EECLEQRQEEAFALRSIYGEKFVERIQNRVWTFSLELEYLtnrlskskqkggcardtatqnskeickfylqggckfgskc 159
Cdd:cd23825 1 DELLEQRQEEAMALESIYGEAFSERIPNKVWTIKLDLPYL---------------------------------------- 40
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 160 rfrhefppnhplrsaknsvddshlrsnrdgPIYELEVRFPEENKYPLQAPLVAFYTTDENLPLACRLHIAEFLFGKALIA 239
Cdd:cd23825 41 ------------------------------PWFELEIRFPKGNKYPYEPPIVAFSSTNENFPKAVCLNITERLMEEALEL 90
|
170 180
....*....|....*....|....*
gi 2024491165 240 AESNEPVVYALVTSLEDESEIGELL 264
Cdd:cd23825 91 AEDGEPVVFSLVSLLEDEEEILELL 115
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
384-564 |
4.65e-24 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 101.03 E-value: 4.65e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 384 RETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDAslqGSPNAVANIICTQPRRISAISVAERVAKERTERVGVTVGY-- 461
Cdd:smart00487 14 KEAIEALLSGLRDVILAAPTGSGKTLAALLPALEA---LKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLyg 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 462 ----QIRLESVKSSATRLLYCTTGVLLRRLE-GDLTLQGITHVIVDEVHeRTEESDFLLLVLKDIMVQRPDLRIILMSAT 536
Cdd:smart00487 91 gdskREQLRKLESGKTDILVTTPGRLLDLLEnDKLSLSNVDLVILDEAH-RLLDGGFGDQLEKLLKLLPKNVQLLLLSAT 169
|
170 180 190
....*....|....*....|....*....|..
gi 2024491165 537 L--NAELFSQYFHSCPIINIPGRT--FPVDQF 564
Cdd:smart00487 170 PpeEIENLLELFLNDPVFIDVGFTplEPIEQF 201
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
876-958 |
1.71e-23 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 95.41 E-value: 1.71e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 876 LGALTADEKLTPLGYHLASLPVDVRIGKLMLFGTIFRCLDPALTIAASLAFKSPFvsPWDKREEANKKKLDFAVGNSDYL 955
Cdd:smart00847 2 LGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADPESDHL 79
|
...
gi 2024491165 956 ALL 958
Cdd:smart00847 80 TLL 82
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
1047-1144 |
1.77e-22 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 92.32 E-value: 1.77e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 1047 ISAMLCAALYPNVVQvKKPEGKYQKTstgavkmqpkaeelkfvTKNDGYVHIHPSSVNYQTRHFESPYLVYHEKIKTSRV 1126
Cdd:pfam07717 1 LRAALAAGLYPNVAR-RDPKGKGYTT-----------------LSDNQRVFIHPSSVLFNEKTFPPEWVVYQELVETTKV 62
|
90
....*....|....*...
gi 2024491165 1127 FIRDCSMVSVYPLVLLGG 1144
Cdd:pfam07717 63 YIRTVTAISPEWLLLFAP 80
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
873-957 |
3.65e-22 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 92.30 E-value: 3.65e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 873 LQDLGALTADEKLTPLGYHLASLPVDVRIGKLMLFGTIFRCLDPALTIAASLAFKSPFVSP-------------WDKREE 939
Cdd:pfam04408 5 LYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPnfldprsaakaarRRRRAA 84
|
90 100
....*....|....*....|
gi 2024491165 940 ANKKKLDFAV--GNSDYLAL 957
Cdd:pfam04408 85 DEKARAKFARldLEGDHLTL 104
|
|
| UBA_DHX57 |
cd14317 |
UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins; DHX57, ... |
19-56 |
6.45e-18 |
|
UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins; DHX57, also called DEAH box protein 57, is a multi-domain protein with an N-terminal ubiquitin-association (UBA) domain, a Zinc finger domain, a RWD domain, a DEAD-like helicase domain and two C-terminal helicase associated domains. Although the precise biological function of DHX57 remains unclear, it may function as a putative ATP-dependent RNA helicase.
Pssm-ID: 270502 Cd Length: 38 Bit Score: 78.12 E-value: 6.45e-18
10 20 30
....*....|....*....|....*....|....*...
gi 2024491165 19 VSPFAVHKLSRYGFDSERCRTVLRSCNGNIGASLEHLL 56
Cdd:cd14317 1 VSPFAVGKLSRYGFDKERCIQALRSNDGDIGAALEHLL 38
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
384-541 |
1.17e-11 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 64.19 E-value: 1.17e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 384 RETILDLLTSHQVLVVSGmTGCGKTT--QIPqfILDASLQGSPNAVANIICtqPRRISAISVAERvAKERTERVGVTV-- 459
Cdd:pfam00270 5 AEAIPAILEGRDVLVQAP-TGSGKTLafLLP--ALEALDKLDNGPQALVLA--PTRELAEQIYEE-LKKLGKGLGLKVas 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 460 ---GYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHeRTEESDF---LLLVLKDImvqRPDLRIILM 533
Cdd:pfam00270 79 llgGDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAH-RLLDMGFgpdLEEILRRL---PKKRQILLL 154
|
....*...
gi 2024491165 534 SATLNAEL 541
Cdd:pfam00270 155 SATLPRNL 162
|
|
| zf_CCCH_4 |
pfam18345 |
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ... |
145-163 |
1.91e-06 |
|
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.
Pssm-ID: 465719 [Multi-domain] Cd Length: 19 Bit Score: 45.10 E-value: 1.91e-06
|
| ZnF_C3H1 |
smart00356 |
zinc finger; |
143-163 |
1.30e-05 |
|
zinc finger;
Pssm-ID: 214632 [Multi-domain] Cd Length: 27 Bit Score: 43.00 E-value: 1.30e-05
|
| UBA |
smart00165 |
Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 ... |
23-56 |
2.21e-03 |
|
Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 is known to bind ubiquitin.
Pssm-ID: 197551 [Multi-domain] Cd Length: 37 Bit Score: 36.70 E-value: 2.21e-03
10 20 30
....*....|....*....|....*....|....
gi 2024491165 23 AVHKLSRYGFDSERCRTVLRSCNGNIGASLEHLL 56
Cdd:smart00165 4 KIDQLLEMGFSREEALKALRAANGNVERAAEYLL 37
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
378-554 |
3.56e-117 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 361.08 E-value: 3.56e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 378 LPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLQGSPNAVANIICTQPRRISAISVAERVAKERTERVGV 457
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPVANIICTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 458 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRPDLRIILMSATL 537
Cdd:cd17985 81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSATL 160
|
170
....*....|....*..
gi 2024491165 538 NAELFSQYFHSCPIINI 554
Cdd:cd17985 161 NAELFSDYFNSCPVIHI 177
|
|
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
378-1003 |
2.04e-115 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 379.81 E-value: 2.04e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 378 LPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASL--QGSpnavanIICTQPRRISAISVAERVAKERTERV 455
Cdd:COG1643 10 LPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWgaGGR------IGMLEPRRLAARAAAERMAEELGEPV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 456 GVTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIM-VQRPDLRIILMS 534
Cdd:COG1643 84 GETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALRPDLKLLVMS 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 535 ATLNAELFSQYFHSCPIINIPGRTFPVDqffledviamTRYvLEDSSPYRRktkqenkvtarhkrtafeeveedlrhagl 614
Cdd:COG1643 164 ATLDAERFARLLGDAPVIESSGRTYPVE----------VRY-RPLPADERD----------------------------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 615 LEDtdtavkdsdpdqkltlkqllkrykGVNKTVLktmsvmdldkvnleliEALLEwivdgkhsyPPGAVLIFLPGLAEIK 694
Cdd:COG1643 204 LED------------------------AVADAVR----------------EALAE---------EPGDILVFLPGEREIR 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 695 MLYEQLQsnalfnNRHSKRCVVYPLHSSLSSEEQQSVFLRPPAGVIKIIISTNIAETSVTIDDVVYVIDSGKMKEKRYDP 774
Cdd:COG1643 235 RTAEALR------GRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDP 308
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 775 SKGMESLEDTFVSRANALQRKGRAGRVASGVCFHLFSSHHYNhQLIKQQLPEIQRVPLEQLCLRIKILEMFSAQSLhsvl 854
Cdd:COG1643 309 RSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFA-RRPAFTDPEILRADLASLILELAAWGLGDPEDL---- 383
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 855 sRLIEPPRTESLRASKLRLQDLGALTADEKLTPLGYHLASLPVDVRIGKLMLFGTIFRCLDPALTIAASLAFKSPFvspw 934
Cdd:COG1643 384 -PFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR---- 458
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024491165 935 dkREEAnkkkldfavgNSDYLALLQAykgWRlstkegsqaSYNYCRENFLSGRVLQEIASLKRQFTELL 1003
Cdd:COG1643 459 --RGAA----------GSDLLARLNL---WR---------RLREQQREFLSYLRLREWRDLARQLRRLL 503
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
376-1132 |
6.41e-89 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 314.40 E-value: 6.41e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 376 QKLPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLqGSPNAVANiicTQPRRISAISVAERVAKERTERV 455
Cdd:TIGR01967 64 DNLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGR-GSHGLIGH---TQPRRLAARTVAQRIAEELGTPL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 456 GVTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRPDLRIILMSA 535
Cdd:TIGR01967 140 GEKVGYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKIIITSA 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 536 TLNAELFSQYFHSCPIINIPGRTFPVDqffledviamTRYvledsspyrrktkqenkvtarhkRTAFEEVEEDlrhagll 615
Cdd:TIGR01967 220 TIDPERFSRHFNNAPIIEVSGRTYPVE----------VRY-----------------------RPLVEEQEDD------- 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 616 edtdtavkDSDPDQKLtlkqllkrykgvnktvlktmsvmdLDKVNlELIEALlewivdgkhsypPGAVLIFLPGLAEIKM 695
Cdd:TIGR01967 260 --------DLDQLEAI------------------------LDAVD-ELFAEG------------PGDILIFLPGEREIRD 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 696 LYEQLqsnalfNNRHSKRCVVYPLHSSLSSEEQQSVFlRPPAGViKIIISTNIAETSVTIDDVVYVIDSGKMKEKRYDPS 775
Cdd:TIGR01967 295 AAEIL------RKRNLRHTEILPLYARLSNKEQQRVF-QPHSGR-RIVLATNVAETSLTVPGIHYVIDTGTARISRYSYR 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 776 KGMESLEDTFVSRANALQRKGRAGRVASGVCFHLFSSHHYNHQLIKQQlPEIQRVPLEQLCLRIKILEMFSAQSLhsvls 855
Cdd:TIGR01967 367 TKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPEFTD-PEILRTNLASVILQMLALRLGDIAAF----- 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 856 RLIEPPRTESLRASKLRLQDLGALTADE---KLTPLGYHLASLPVDVRIGKLMLFGTIFRCLDPALTIAASLAFKSPFVS 932
Cdd:TIGR01967 441 PFIEAPDPRAIRDGFRLLEELGALDDDEaepQLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRER 520
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 933 PWDKREEANKKKLDFAVGNSDYLALLQAYKGWRLSTKEGSQASY-NYCRENFLSGRVLQEIASLKRQFTELLSDIGfvke 1011
Cdd:TIGR01967 521 PMEKQQAADQAHARFKDPRSDFLSRVNLWRHIEEQRQALSANQFrNACRKQYLNYLRVREWQDIYRQLTQVVKELG---- 596
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 1012 glrardierkWSqggdgvldatgeeANSNAENFKLISAMLCAALYPNVVQvKKPEGKYQktstgavkmqpKAEELKFvtk 1091
Cdd:TIGR01967 597 ----------LK-------------LNEEPADYDAIHKALLSGLLSQIGM-KDEKHEYD-----------GARGRKF--- 638
|
730 740 750 760
....*....|....*....|....*....|....*....|.
gi 2024491165 1092 ndgyvHIHPSSVNYQTRhfeSPYLVYHEKIKTSRVFIRDCS 1132
Cdd:TIGR01967 639 -----HIFPGSPLFKKP---PKWVMAAELVETSKLYARLVA 671
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
394-554 |
9.09e-89 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 283.20 E-value: 9.09e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 394 HQVLVVSGMTGCGKTTQIPQFILDASLQGSPNAvaNIICTQPRRISAISVAERVAKERTERVGVTVGYQIRLESVKSSAT 473
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKGGKG--RIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 474 RLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRPDLRIILMSATLNAELFSQYFHSCPIIN 553
Cdd:cd17917 79 RIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVIH 158
|
.
gi 2024491165 554 I 554
Cdd:cd17917 159 I 159
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
387-952 |
3.34e-76 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 270.10 E-value: 3.34e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 387 ILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLQGSpnavaNIICTQPRRISAISVAERVAKERTERVGVTVGYQIRLE 466
Cdd:TIGR01970 10 LRDALAAHPQVVLEAPPGAGKSTAVPLALLDAPGIGG-----KIIMLEPRRLAARSAAQRLASQLGEAVGQTVGYRVRGE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 467 SVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQ-RPDLRIILMSATLNAELFSQY 545
Cdd:TIGR01970 85 NKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSSlREDLKILAMSATLDGERLSSL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 546 FHSCPIINIPGRTFPVDqffledviamTRYVledssPYRRKTKQENKVtarhKRTafeeVEEDLRHAglledtdtavkds 625
Cdd:TIGR01970 165 LPDAPVVESEGRSFPVE----------IRYL-----PLRGDQRLEDAV----SRA----VEHALASE------------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 626 dpdqkltlkqllkrykgvnktvlktmsvmdldkvnlelieallewivdgkhsypPGAVLIFLPGLAEIKMLYEQLQSnal 705
Cdd:TIGR01970 209 ------------------------------------------------------TGSILVFLPGQAEIRRVQEQLAE--- 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 706 fnnRHSKRCVVYPLHSSLSSEEQQSVFLRPPAGVIKIIISTNIAETSVTIDDVVYVIDSGKMKEKRYDPSKGMESLEDTF 785
Cdd:TIGR01970 232 ---RLDSDVLICPLYGELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITRLETVR 308
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 786 VSRANALQRKGRAGRVASGVCFHLFSSHHYNhQLIKQQLPEIQRVPLEQLCLRikiLEMFSAQSLhSVLSRLIEPPRTES 865
Cdd:TIGR01970 309 ISQASATQRAGRAGRLEPGVCYRLWSEEQHQ-RLPAQDEPEILQADLSGLALE---LAQWGAKDP-SDLRWLDAPPSVAL 383
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 866 LRASKLrLQDLGALTADEKLTPLGYHLASLPVDVRIGKLMLFGTIFRCLDPALTIAA-----------------SLAFKS 928
Cdd:TIGR01970 384 AAARQL-LQRLGALDAQGRLTAHGKAMAALGCHPRLAAMLLSAHSTGLAALACDLAAlleerglprqggadlmnRLHRLQ 462
|
570 580
....*....|....*....|....
gi 2024491165 929 PFVSPWDKREEANKKKLDFAVGNS 952
Cdd:TIGR01970 463 QGRQGRGQRAQQLAKKLRRRLRFS 486
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
378-985 |
5.19e-76 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 275.79 E-value: 5.19e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 378 LPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLqgspnAVANIIC-TQPRRISAISVAERVAKERTERVG 456
Cdd:PRK11131 73 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGR-----GVKGLIGhTQPRRLAARTVANRIAEELETELG 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 457 VTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRPDLRIILMSAT 536
Cdd:PRK11131 148 GCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSAT 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 537 LNAELFSQYFHSCPIINIPGRTFPVDqffledviamTRYvledsSPyrrktkqenkvtarhkrtafeeveedlrhagLLE 616
Cdd:PRK11131 228 IDPERFSRHFNNAPIIEVSGRTYPVE----------VRY-----RP-------------------------------IVE 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 617 DTDtavkDSDPDQkltlkqllkrykgvnktvlktmsvmdldkvnlelIEALLEwIVDGKHSYPPGAVLIFLPGLAEIKML 696
Cdd:PRK11131 262 EAD----DTERDQ----------------------------------LQAIFD-AVDELGREGPGDILIFMSGEREIRDT 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 697 YEQLQSNALfnnRHSKrcvVYPLHSSLSSEEQQSVFlrPPAGVIKIIISTNIAETSVTIDDVVYVIDSGKMKEKRYDPSK 776
Cdd:PRK11131 303 ADALNKLNL---RHTE---ILPLYARLSNSEQNRVF--QSHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRT 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 777 GMESLEDTFVSRANALQRKGRAGRVASGVCFHLFSSHHYNHqliKQQL--PEIQRVPLEQLclrikILEMfSAQSLHSVL 854
Cdd:PRK11131 375 KVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLS---RPEFtdPEILRTNLASV-----ILQM-TALGLGDIA 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 855 S-RLIEPPRTESLRASKLRLQDLGALTADE-----KLTPLGYHLASLPVDVRIGKLMLFGTIFRCLDPALTIAASLAFKS 928
Cdd:PRK11131 446 AfPFVEAPDKRNIQDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQD 525
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*...
gi 2024491165 929 PFVSPWDKREEANKKKLDFAVGNSDYLALLQAYKGWRLSTKEGSQASY-NYCRENFLS 985
Cdd:PRK11131 526 PRERPMDKQQASDEKHRRFADKESDFLAFVNLWNYLQEQQKALSSNQFrRLCRTDYLN 583
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
368-554 |
2.53e-68 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 229.34 E-value: 2.53e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 368 FQSMLHERQKLPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLQGSPNAVANIICTQPRRISAISVAERV 447
Cdd:cd17972 49 LQQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFIQNDRAAECNIVVTQPRRISAVSVAERV 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 448 AKERTERVGVTVGYQIRLESV-KSSATRLLYCTTGVLLRRLEGDltLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRP 526
Cdd:cd17972 129 AFERGEEVGKSCGYSVRFESVlPRPHASILFCTVGVLLRKLEAG--IRGISHVIVDEIHERDINTDFLLVVLRDVVQAYP 206
|
170 180
....*....|....*....|....*...
gi 2024491165 527 DLRIILMSATLNAELFSQYFHSCPIINI 554
Cdd:cd17972 207 DLRVILMSATIDTSMFCEYFFNCPVIEV 234
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
378-554 |
4.03e-68 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 226.65 E-value: 4.03e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 378 LPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLQGSPNAVANIICTQPRRISAISVAERVAKERTERVGV 457
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGSSCRIVCTQPRRISAISVAERVAAERAESCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 458 --TVGYQIRLESVKS-SATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRPDLRIILMS 534
Cdd:cd17981 81 gnSTGYQIRLESRKPrKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160
|
170 180
....*....|....*....|
gi 2024491165 535 ATLNAELFSQYFHSCPIINI 554
Cdd:cd17981 161 ATLNAEKFSDYFNNCPMIHI 180
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
651-810 |
2.51e-66 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 221.25 E-value: 2.51e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 651 MSVMDLDKVNLELIEALLEWIVdgkHSYPPGAVLIFLPGLAEIKMLYEQLQSNALFNNRHskRCVVYPLHSSLSSEEQQS 730
Cdd:cd18791 17 ISSEKEDPDYVDAAVRLILQIH---RTEEPGDILVFLPGQEEIERLCELLREELLSPDLG--KLLVLPLHSSLPPEEQQR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 731 VFLRPPAGVIKIIISTNIAETSVTIDDVVYVIDSGKMKEKRYDPSKGMESLEDTFVSRANALQRKGRAGRVASGVCFHLF 810
Cdd:cd18791 92 VFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
378-554 |
1.91e-65 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 219.02 E-value: 1.91e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 378 LPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFIL-DASLQGSPNAVANIICTQPRRISAISVAERVAKERTERVG 456
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLeDLLLNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 457 -----VTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRPDLRII 531
Cdd:cd17975 81 pggknSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLI 160
|
170 180
....*....|....*....|...
gi 2024491165 532 LMSATLNAELFSQYFHSCPIINI 554
Cdd:cd17975 161 LMSATVDCEKFSSYFTHCPILRI 183
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
378-554 |
6.74e-65 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 217.39 E-value: 6.74e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 378 LPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLQ-GSPnavANIICTQPRRISAISVAERVAKERTERVG 456
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYAnGIP---CRIFCTQPRRLAAIAVAERVAAERGEKIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 457 VTVGYQIRLESVKSSATRLLYCTTGVLLRRL-EGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRPDLRIILMSA 535
Cdd:cd17987 78 QTVGYQIRLESRVSPKTLLTFCTNGVLLRTLmAGDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSA 157
|
170
....*....|....*....
gi 2024491165 536 TLNAELFSQYFHSCPIINI 554
Cdd:cd17987 158 ALDVNLFIRYFGSCPVIYI 176
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
378-554 |
8.85e-64 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 214.27 E-value: 8.85e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 378 LPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLQGSPNAVANIICTQPRRISAISVAERVAKERTERVGV 457
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 458 TVGYQIRLES-VKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRPDLRIILMSAT 536
Cdd:cd17976 81 NVGYQVRLESrPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160
|
170
....*....|....*...
gi 2024491165 537 LNAELFSQYFHSCPIINI 554
Cdd:cd17976 161 GDNQRLSRYFGGCPVVRV 178
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
390-925 |
3.62e-61 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 225.57 E-value: 3.62e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 390 LLTSHQVLVvSGMTGCGKTTQIP-QFILDASLQGspnavaNIICTQPRRISAISVAERVAKERTERVGVTVGYQIRLESV 468
Cdd:PRK11664 17 LKTAPQVLL-KAPTGAGKSTWLPlQLLQHGGING------KIIMLEPRRLAARNVAQRLAEQLGEKPGETVGYRMRAESK 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 469 KSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDimVQ---RPDLRIILMSATLNAELFSQY 545
Cdd:PRK11664 90 VGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLD--VQqglRDDLKLLIMSATLDNDRLQQL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 546 FHSCPIINIPGRTFPVDqffledviamTRYvledsspyrrktkqenKVTARHKRtaFEEveedlrhaglledtdtavkds 625
Cdd:PRK11664 168 LPDAPVIVSEGRSFPVE----------RRY----------------QPLPAHQR--FDE--------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 626 dpdqkltlkqllkrykGVNKTVLKTMsvmdldkvNLElieallewivdgkhsypPGAVLIFLPGLAEIKMLYEQLQsnal 705
Cdd:PRK11664 199 ----------------AVARATAELL--------RQE-----------------SGSLLLFLPGVGEIQRVQEQLA---- 233
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 706 fnNRHSKRCVVYPLHSSLSSEEQQSVFLRPPAGVIKIIISTNIAETSVTIDDVVYVIDSGKMKEKRYDPSKGMESLEDTF 785
Cdd:PRK11664 234 --SRVASDVLLCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQR 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 786 VSRANALQRKGRAGRVASGVCFHLFSSHHYNhQLIKQQLPEIQRVPLEQLCLRikiLEMFSAQSLHSvLSRLIEPPRTeS 865
Cdd:PRK11664 312 ISQASMTQRAGRAGRLEPGICLHLYSKEQAE-RAAAQSEPEILHSDLSGLLLE---LLQWGCHDPAQ-LSWLDQPPAA-A 385
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 866 LRASKLRLQDLGALTADEKLTPLGYHLASLPVDVRIGKLMLFGTIFRclDPALTIAASLA 925
Cdd:PRK11664 386 LAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLAAMLVAAKEDD--EAALATAAKLA 443
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
367-554 |
4.33e-60 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 204.19 E-value: 4.33e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 367 RFQSMLHERQKLPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLQGSPNAVanIICTQPRRISAISVAER 446
Cdd:cd17973 2 RYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPKKL--VACTQPRRVAAMSVAQR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 447 VAKERTERVGVTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRP 526
Cdd:cd17973 80 VAEEMDVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRP 159
|
170 180
....*....|....*....|....*...
gi 2024491165 527 DLRIILMSATLNAELFSQYFHSCPIINI 554
Cdd:cd17973 160 DLKLIVMSATLDAGKFQKYFDNAPLLKV 187
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
378-554 |
2.10e-58 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 198.44 E-value: 2.10e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 378 LPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLQgspnavaNIICTQPRRISAISVAERVAKERTERVGV 457
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFR-------HIACTQPRRIACISLAKRVAFESLNQYGS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 458 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRPDLRIILMSATL 537
Cdd:cd17979 74 KVAYQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATI 153
|
170
....*....|....*..
gi 2024491165 538 NAELFSQYFHSCPIINI 554
Cdd:cd17979 154 NIELFSGYFEGAPVVQV 170
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
378-561 |
2.20e-53 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 184.63 E-value: 2.20e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 378 LPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLQGSPNAvaNIICTQPRRISAISVAERVAKERTERVGV 457
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYKRGKYC--NIVVTQPRRIAAISIARRVSQEREWTLGS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 458 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIM-VQRPDLRIILMSAT 536
Cdd:cd17988 79 LVGYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLrTNSRHVKIILMSAT 158
|
170 180
....*....|....*....|....*
gi 2024491165 537 LNAELFSQYFHScpiINIPGRTFPV 561
Cdd:cd17988 159 ISCKEFADYFTT---PNNPAYVFEV 180
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
378-554 |
6.56e-53 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 183.32 E-value: 6.56e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 378 LPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLQGSpnavANIICTQPRRISAISVAERVAKERTERVGV 457
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARG----GMIGITQPRRVAAVSVAKRVAEEMGVELGQ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 458 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQR-----PDLRIIL 532
Cdd:cd17978 77 LVGYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLKVII 156
|
170 180
....*....|....*....|..
gi 2024491165 533 MSATLNAELFSQYFHSCPIINI 554
Cdd:cd17978 157 MSATLDADLFSEYFNGAPVLYI 178
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
374-555 |
2.48e-51 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 178.83 E-value: 2.48e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 374 ERQKLPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLQGSpnavANIICTQPRRISAISVAERVAKERTE 453
Cdd:cd17971 2 QRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSR----GKIGCTQPRRVAAMSVAKRVAEEFGC 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 454 RVGVTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRPDLRIILM 533
Cdd:cd17971 78 CLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVT 157
|
170 180
....*....|....*....|..
gi 2024491165 534 SATLNAELFSQYFHSCPIINIP 555
Cdd:cd17971 158 SATLDAVKFSQYFYEAPIFTIP 179
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
378-554 |
2.57e-51 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 178.47 E-value: 2.57e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 378 LPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDAslqGSPNAVANIICTQPRRISAISVAERVAKERTERVGV 457
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEA---GYTKGGGKIGCTQPRRVAAMSVAARVAEEMGVKLGN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 458 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRPDLRIILMSATL 537
Cdd:cd17974 78 EVGYSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATM 157
|
170
....*....|....*..
gi 2024491165 538 NAELFSQYFHSCPIINI 554
Cdd:cd17974 158 DAEKFSAFFDDAPIFRI 174
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
378-548 |
2.33e-49 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 173.42 E-value: 2.33e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 378 LPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLQGSPNAVAniiCTQPRRISAISVAERVAKERTERVGV 457
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTAGGRVVG---CTQPRRVAAVTVAGRVAEEMGAVLGH 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 458 TVGYQIRLESVKSS-ATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRPDLRIILMSAT 536
Cdd:cd17980 78 EVGYCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASAT 157
|
170
....*....|..
gi 2024491165 537 LNAELFSQYFHS 548
Cdd:cd17980 158 LDAEKFRDFFNQ 169
|
|
| RWD_DHX57 |
cd23825 |
RWD domain of DEAH box protein 57 (DHX57) and related proteins; DHX57 (EC 3.6.4.13) is a ... |
80-264 |
1.07e-47 |
|
RWD domain of DEAH box protein 57 (DHX57) and related proteins; DHX57 (EC 3.6.4.13) is a putative ATP-dependent RNA helicase. A genome-wide association study (GWAS) of cerebellar epigenetic age acceleration identified significant SNPs (single nucleotide polymorphisms) in a loci 2p22.1 inside the DHX57 gene, suggesting that variants in DHX57 are associated with epigenetic age in the cerebellum.
Pssm-ID: 467661 Cd Length: 115 Bit Score: 165.83 E-value: 1.07e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 80 EECLEQRQEEAFALRSIYGEKFVERIQNRVWTFSLELEYLtnrlskskqkggcardtatqnskeickfylqggckfgskc 159
Cdd:cd23825 1 DELLEQRQEEAMALESIYGEAFSERIPNKVWTIKLDLPYL---------------------------------------- 40
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 160 rfrhefppnhplrsaknsvddshlrsnrdgPIYELEVRFPEENKYPLQAPLVAFYTTDENLPLACRLHIAEFLFGKALIA 239
Cdd:cd23825 41 ------------------------------PWFELEIRFPKGNKYPYEPPIVAFSSTNENFPKAVCLNITERLMEEALEL 90
|
170 180
....*....|....*....|....*
gi 2024491165 240 AESNEPVVYALVTSLEDESEIGELL 264
Cdd:cd23825 91 AEDGEPVVFSLVSLLEDEEEILELL 115
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
378-554 |
2.66e-44 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 158.39 E-value: 2.66e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 378 LPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLqGSPNAVANiicTQPRRISAISVAERVAKERTERVGV 457
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGR-GIRGLIGH---TQPRRLAARSVAERIAEELKTELGG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 458 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRPDLRIILMSATL 537
Cdd:cd17989 77 AVGYKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATI 156
|
170
....*....|....*..
gi 2024491165 538 NAELFSQYFHSCPIINI 554
Cdd:cd17989 157 DAERFSRHFNNAPIIEV 173
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
378-554 |
1.21e-43 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 156.47 E-value: 1.21e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 378 LPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLQGSpnavANIICTQPRRISAISVAERVAKERTERVGV 457
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTDY----GMIGCTQPRRVAAMSVAKRVSEEMGVELGE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 458 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRPDLRIILMSATL 537
Cdd:cd17983 77 EVGYAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSATM 156
|
170
....*....|....*..
gi 2024491165 538 NAELFSQYFHSCPIINI 554
Cdd:cd17983 157 DADKFADFFGNVPIFTI 173
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
387-552 |
3.74e-43 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 155.18 E-value: 3.74e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 387 ILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLqgspNAVANIICTQPRRISAISVAERVAKERTERVGVTVGYQIRLE 466
Cdd:cd17990 10 LRAALDAGGQVVLEAPPGAGKTTRVPLALLAELW----IAGGKIIVLEPRRVAARAAARRLATLLGEAPGETVGYRVRGE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 467 SVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIM-VQRPDLRIILMSATLNAELFSQY 545
Cdd:cd17990 86 SRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQqLLRDDLRLLAMSATLDGDGLAAL 165
|
....*..
gi 2024491165 546 FHSCPII 552
Cdd:cd17990 166 LPEAPVV 172
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
378-544 |
4.66e-40 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 146.73 E-value: 4.66e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 378 LPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLqGSPNAVAN--IICTQPRRISAISVAERVAKErTERV 455
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGF-GSPESDNPgmIGITQPRRVAAVSMAKRVAEE-LNVF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 456 GVTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRPD-------- 527
Cdd:cd17982 79 GKEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqtv 158
|
170
....*....|....*....
gi 2024491165 528 --LRIILMSATLNAELFSQ 544
Cdd:cd17982 159 kpLKLVIMSATLRVEDFTE 177
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
378-554 |
3.91e-37 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 138.06 E-value: 3.91e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 378 LPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLqgSPNAVanIICTQPRRISAISVAERVAKERTERVGV 457
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGF--SQHGM--IGVTQPRRVAAISVAQRVAEEMKCTLGS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 458 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRP-----DLRIIL 532
Cdd:cd17984 77 KVGYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSpnrkeHLKVVV 156
|
170 180
....*....|....*....|..
gi 2024491165 533 MSATLNAELFSQYFHSCPIINI 554
Cdd:cd17984 157 MSATLELAKLSAFFGNCPVFDI 178
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
378-554 |
2.85e-34 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 129.56 E-value: 2.85e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 378 LPAWQERETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLQGSPNAVAnIICTQPRRISAISVAERVAKERTERVGV 457
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAHYQHGV-VVCTQVHKQTAVWLALRVADEMDVNIGH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 458 TVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRPDLRIILMSATL 537
Cdd:cd17977 80 EVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITCPH 159
|
170
....*....|....*..
gi 2024491165 538 NAELFSQYFHSCPIINI 554
Cdd:cd17977 160 LSSKLLSYYGNVPLIEV 176
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
378-554 |
8.21e-27 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 108.45 E-value: 8.21e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 378 LPAWQERETILDLLTSHQ-VLVVSGMTGCGKTTQIPQFILDASLqGSPNAVANIICTQPRRISAISVAERVAKERTERVG 456
Cdd:cd17986 1 LPIWAAKFTFLEQLESPSgIVLVSGEPGSGKSTQVPQWCAEFAL-SRGFQKGQVTVTQPHPLAARSLALRVADEMDLNLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 457 VTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHERTEESDFLLLVLKDIMVQRPDLRIILMSAT 536
Cdd:cd17986 80 HEVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVTSP 159
|
170
....*....|....*...
gi 2024491165 537 LNAELFSQYFHSCPIINI 554
Cdd:cd17986 160 ALEPKLRAFWGNPPVVHV 177
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
384-564 |
4.65e-24 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 101.03 E-value: 4.65e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 384 RETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDAslqGSPNAVANIICTQPRRISAISVAERVAKERTERVGVTVGY-- 461
Cdd:smart00487 14 KEAIEALLSGLRDVILAAPTGSGKTLAALLPALEA---LKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLyg 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 462 ----QIRLESVKSSATRLLYCTTGVLLRRLE-GDLTLQGITHVIVDEVHeRTEESDFLLLVLKDIMVQRPDLRIILMSAT 536
Cdd:smart00487 91 gdskREQLRKLESGKTDILVTTPGRLLDLLEnDKLSLSNVDLVILDEAH-RLLDGGFGDQLEKLLKLLPKNVQLLLLSAT 169
|
170 180 190
....*....|....*....|....*....|..
gi 2024491165 537 L--NAELFSQYFHSCPIINIPGRT--FPVDQF 564
Cdd:smart00487 170 PpeEIENLLELFLNDPVFIDVGFTplEPIEQF 201
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
876-958 |
1.71e-23 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 95.41 E-value: 1.71e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 876 LGALTADEKLTPLGYHLASLPVDVRIGKLMLFGTIFRCLDPALTIAASLAFKSPFvsPWDKREEANKKKLDFAVGNSDYL 955
Cdd:smart00847 2 LGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADPESDHL 79
|
...
gi 2024491165 956 ALL 958
Cdd:smart00847 80 TLL 82
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
1047-1144 |
1.77e-22 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 92.32 E-value: 1.77e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 1047 ISAMLCAALYPNVVQvKKPEGKYQKTstgavkmqpkaeelkfvTKNDGYVHIHPSSVNYQTRHFESPYLVYHEKIKTSRV 1126
Cdd:pfam07717 1 LRAALAAGLYPNVAR-RDPKGKGYTT-----------------LSDNQRVFIHPSSVLFNEKTFPPEWVVYQELVETTKV 62
|
90
....*....|....*...
gi 2024491165 1127 FIRDCSMVSVYPLVLLGG 1144
Cdd:pfam07717 63 YIRTVTAISPEWLLLFAP 80
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
873-957 |
3.65e-22 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 92.30 E-value: 3.65e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 873 LQDLGALTADEKLTPLGYHLASLPVDVRIGKLMLFGTIFRCLDPALTIAASLAFKSPFVSP-------------WDKREE 939
Cdd:pfam04408 5 LYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPnfldprsaakaarRRRRAA 84
|
90 100
....*....|....*....|
gi 2024491165 940 ANKKKLDFAV--GNSDYLAL 957
Cdd:pfam04408 85 DEKARAKFARldLEGDHLTL 104
|
|
| UBA_DHX57 |
cd14317 |
UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins; DHX57, ... |
19-56 |
6.45e-18 |
|
UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins; DHX57, also called DEAH box protein 57, is a multi-domain protein with an N-terminal ubiquitin-association (UBA) domain, a Zinc finger domain, a RWD domain, a DEAD-like helicase domain and two C-terminal helicase associated domains. Although the precise biological function of DHX57 remains unclear, it may function as a putative ATP-dependent RNA helicase.
Pssm-ID: 270502 Cd Length: 38 Bit Score: 78.12 E-value: 6.45e-18
10 20 30
....*....|....*....|....*....|....*...
gi 2024491165 19 VSPFAVHKLSRYGFDSERCRTVLRSCNGNIGASLEHLL 56
Cdd:cd14317 1 VSPFAVGKLSRYGFDKERCIQALRSNDGDIGAALEHLL 38
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
387-804 |
1.62e-13 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 75.01 E-value: 1.62e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 387 ILDLLTSHQVLVVSGMTGCGKTTQIPQFI------------LDASlqgSPNAVAN-IICTQPR----RISAISVAERVAK 449
Cdd:PHA02653 172 IFEAWISRKPVVLTGGTGVGKTSQVPKLLlwfnylfggfdnLDKI---DPNFIERpIVLSLPRvalvRLHSITLLKSLGF 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 450 ERTERVGVTVGY---QIRLESVKSSATRLLYCTTgvllrrlegDLTLQGITH---VIVDEVHERTEESDFLLLVL-KDIM 522
Cdd:PHA02653 249 DEIDGSPISLKYgsiPDELINTNPKPYGLVFSTH---------KLTLNKLFDygtVIIDEVHEHDQIGDIIIAVArKHID 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 523 VQRpdlRIILMSATL--NAELFSQYFHSCPIINIPGRT-FPVDQFfledviamtrYVLEDSSPYRRktkqenkvtarhkr 599
Cdd:PHA02653 320 KIR---SLFLMTATLedDRDRIKEFFPNPAFVHIPGGTlFPISEV----------YVKNKYNPKNK-------------- 372
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 600 taFEEVEEDLRhaglleDTDTAVKDSDPDQKltlkqllkrYKGVnkTVLKTMSVMDLDKVNLE-LIEALLEWIVDGKhsy 678
Cdd:PHA02653 373 --RAYIEEEKK------NIVTALKKYTPPKG---------SSGI--VFVASVSQCEEYKKYLEkRLPIYDFYIIHGK--- 430
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 679 ppgavlifLPGLAEIkmlyeqlqSNALFNNRHskrcvvyplhsslsseeqqsvflrppagvIKIIISTNIAETSVTIDDV 758
Cdd:PHA02653 431 --------VPNIDEI--------LEKVYSSKN-----------------------------PSIIISTPYLESSVTIRNA 465
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 2024491165 759 VYVIDSGKMKEKRydPSKGMEsledTFVSRANALQRKGRAGRVASG 804
Cdd:PHA02653 466 THVYDTGRVYVPE--PFGGKE----MFISKSMRTQRKGRVGRVSPG 505
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
403-536 |
2.35e-13 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 68.58 E-value: 2.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 403 TGCGKTTQIPQFILDASLQGSPNAVanIICtqPRRISAISVAERVAKERTE--RVGVTVGY---QIRLESVKSSAtRLLY 477
Cdd:cd00046 10 TGSGKTLAALLAALLLLLKKGKKVL--VLV--PTKALALQTAERLRELFGPgiRVAVLVGGssaEEREKNKLGDA-DIII 84
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024491165 478 CTTGVLLRRLEGD--LTLQGITHVIVDEVHERTEESDFLLLV-LKDIMVQRPDLRIILMSAT 536
Cdd:cd00046 85 ATPDMLLNLLLREdrLFLKDLKLIIVDEAHALLIDSRGALILdLAVRKAGLKNAQVILLSAT 146
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
384-541 |
1.17e-11 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 64.19 E-value: 1.17e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 384 RETILDLLTSHQVLVVSGmTGCGKTT--QIPqfILDASLQGSPNAVANIICtqPRRISAISVAERvAKERTERVGVTV-- 459
Cdd:pfam00270 5 AEAIPAILEGRDVLVQAP-TGSGKTLafLLP--ALEALDKLDNGPQALVLA--PTRELAEQIYEE-LKKLGKGLGLKVas 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 460 ---GYQIRLESVKSSATRLLYCTTGVLLRRLEGDLTLQGITHVIVDEVHeRTEESDF---LLLVLKDImvqRPDLRIILM 533
Cdd:pfam00270 79 llgGDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAH-RLLDMGFgpdLEEILRRL---PKKRQILLL 154
|
....*...
gi 2024491165 534 SATLNAEL 541
Cdd:pfam00270 155 SATLPRNL 162
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
662-801 |
3.88e-09 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 55.29 E-value: 3.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 662 ELIEALLEWIvdgkHSYPPGAVLIFLPGlaeikmlYEQLQSNALFNNRHSKrcvVYPLHSSLSSEEQQSVFLRPPAGVIK 741
Cdd:pfam00271 1 EKLEALLELL----KKERGGKVLIFSQT-------KKTLEAELLLEKEGIK---VARLHGDLSQEEREEILEDFRKGKID 66
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 742 IIISTNIAETSVTIDDVVYVIDsgkmkekrYDPSKGMESLedtfvsranaLQRKGRAGRV 801
Cdd:pfam00271 67 VLVATDVAERGLDLPDVDLVIN--------YDLPWNPASY----------IQRIGRAGRA 108
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
716-800 |
8.99e-09 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 53.37 E-value: 8.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 716 VYPLHSSLSSEEQQSVFLRPPAGVIKIIISTNIAETSVTIDDVVYVIDSgkmkekrydpskgmesleDTFVSRANALQRK 795
Cdd:smart00490 14 VARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIY------------------DLPWSPASYIQRI 75
|
....*
gi 2024491165 796 GRAGR 800
Cdd:smart00490 76 GRAGR 80
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
381-555 |
3.04e-08 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 54.96 E-value: 3.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 381 WQeRETILDLLTSHQVLVVSGMTGCGKTTQIPQFILDASLQGSPNAVAniicTQPRRisAIsVAERVA--KERTERVGVT 458
Cdd:cd17921 5 IQ-REALRALYLSGDSVLVSAPTSSGKTLIAELAILRALATSGGKAVY----IAPTR--AL-VNQKEAdlRERFGPLGKN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491165 459 VGYQIRLESV---KSSATRLLYCTT---GVLLRRLEGDLtLQGITHVIVDEVH--ERTEESDFLLLVLKDIMVQRPDLRI 530
Cdd:cd17921 77 VGLLTGDPSVnklLLAEADILVATPeklDLLLRNGGERL-IQDVRLVVVDEAHliGDGERGVVLELLLSRLLRINKNARF 155
|
170 180
....*....|....*....|....*.
gi 2024491165 531 ILMSATL-NAELFSQYFHSCPIINIP 555
Cdd:cd17921 156 VGLSATLpNAEDLAEWLGVEDLIRFD 181
|
|
| zf_CCCH_4 |
pfam18345 |
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ... |
145-163 |
1.91e-06 |
|
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.
Pssm-ID: 465719 [Multi-domain] Cd Length: 19 Bit Score: 45.10 E-value: 1.91e-06
|
| zf-CCCH_4 |
pfam18044 |
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ... |
144-163 |
2.28e-06 |
|
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.
Pssm-ID: 465626 Cd Length: 22 Bit Score: 44.89 E-value: 2.28e-06
|
| ZnF_C3H1 |
smart00356 |
zinc finger; |
143-163 |
1.30e-05 |
|
zinc finger;
Pssm-ID: 214632 [Multi-domain] Cd Length: 27 Bit Score: 43.00 E-value: 1.30e-05
|
| zf-CCCH |
pfam00642 |
Zinc finger C-x8-C-x5-C-x3-H type (and similar); |
142-163 |
1.69e-04 |
|
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
Pssm-ID: 459885 [Multi-domain] Cd Length: 27 Bit Score: 39.87 E-value: 1.69e-04
|
| UBA |
smart00165 |
Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 ... |
23-56 |
2.21e-03 |
|
Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 is known to bind ubiquitin.
Pssm-ID: 197551 [Multi-domain] Cd Length: 37 Bit Score: 36.70 E-value: 2.21e-03
10 20 30
....*....|....*....|....*....|....
gi 2024491165 23 AVHKLSRYGFDSERCRTVLRSCNGNIGASLEHLL 56
Cdd:smart00165 4 KIDQLLEMGFSREEALKALRAANGNVERAAEYLL 37
|
|
| zf-CCCH_2 |
pfam14608 |
RNA-binding, Nab2-type zinc finger; This is an unusual zinc-finger family, and is represented ... |
144-163 |
2.34e-03 |
|
RNA-binding, Nab2-type zinc finger; This is an unusual zinc-finger family, and is represented by fingers 5-7 of Nab2. Nab2 ZnF5-7 are zinc-fingers of the type C-x8-C-x5-C-x3-H. Nab2 ZnFs function in the generation of export-competent mRNPs. Mab2 is a conserved polyadenosine-RNA-binding Zn finger protein required for both mRNA export and polyadenylation regulation and becomes attached to the mRNP after splicing and during or immediately after polyadenylation. The three ZnFs, 5-7, have almost identical folds and, most unusually, associate with one another to form a single coherent structural unit. ZnF5-7 bind to eight consecutive adenines, and chemical shift perturbations identify residues on each finger that interact with RNA.
Pssm-ID: 464217 Cd Length: 19 Bit Score: 36.34 E-value: 2.34e-03
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
739-800 |
3.92e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 37.30 E-value: 3.92e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024491165 739 VIKIIISTNIAETSVTIDDVVYVIdsgkmkekRYDPSKgmesledtfvSRANALQRKGRAGR 800
Cdd:cd18785 22 SLEILVATNVLGEGIDVPSLDTVI--------FFDPPS----------SAASYIQRVGRAGR 65
|
|
| |
