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Conserved domains on  [gi|2024506736|ref|XP_040529779|]
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MAX gene-associated protein isoform X6 [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
T-box_MGA-like cd20195
DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known ...
 75-260 3.87e-138

DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known as MGAP, MAX dimerization protein, MAD5, MXD5) is a dual-specificity transcription factor that regulates the expression of both, MAX-network and T-box family target genes. MGA functions as a repressor or an activator; it binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence. Its function is activated by heterodimerization with MAX. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


:

Pssm-ID: 410321  Cd Length: 186  Bit Score: 428.78  E-value: 3.87e-138
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLG 154
Cdd:cd20195      1 ITVTLENNSMWNEFYRCGTEMILTKQGRRMFPYCRFRISGLDPDRNYILVMDISPVDNFRYRWNGRWWEPSGKAEPHVLG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  155 RVFIHPESPSTGQYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPADKATEVIQLNGPDVHTFTFPQTEFF 234
Cdd:cd20195     81 RVFIHPESPATGRHWMDQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHVVPADKEVDVIQLNGPDVHTFTFPQTEFF 160

                          170       180
                   ....*....|....*....|....*.
gi 2024506736  235 AVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20195    161 AVTAYQNKQITQLKIDYNPFAKGFRE 186
bHLH_SF super family cl00081
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
 2534-2597 5.24e-22

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


The actual alignment was detected with superfamily member cd18911:

Pssm-ID: 469605  Cd Length: 65  Bit Score: 91.77  E-value: 5.24e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024506736 2534 RQTHTANERRRRNEMRDLFEKLKRALGLHSLPKVSKCYILKQALDEIQGLTDQADKLTGQKCIL 2597
Cdd:cd18911      1 RRTHTANERRRRNEMRDLFEKLKRTLGLHNLPKVSKYYILKQAFEEIQGLTDQADRLIGQKTLL 64
MGA_dom super family cl24582
MGA, conserved domain; This domain can be found in the MAX gene-associated protein (Mga), ...
 1028-1069 2.81e-14

MGA, conserved domain; This domain can be found in the MAX gene-associated protein (Mga), which is a dual-specificity transcription factor that contains both a bHLHZip domain and a T-box domain and is able to bind to and regulate transcriptional targets through both E-box sites as well as T-box-binding elements (TBEs).


The actual alignment was detected with superfamily member pfam16059:

Pssm-ID: 464998  Cd Length: 51  Bit Score: 69.44  E-value: 2.81e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2024506736 1028 RRRAPPCNNDFCRLGCICASLA-LEKRQPTHCRRPDCMFGCTC 1069
Cdd:pfam16059    2 KDAKKPCDKDYCQLGCVCDSLAgTRPPKREHCGRADCVLGCVC 44
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1526-1970 1.38e-10

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 1.38e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1526 SSASGTPSVQVPTTSAPKT-TSSISTTSNPSVTTLKALIPPLRQIAARPSPGGVFTKFVMNKVGALQQ-----KIPSVST 1599
Cdd:PHA03247  2608 PRGPAPPSPLPPDTHAPDPpPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQassppQRPRRRA 2687

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1600 CQPLSGPQKFSINPTPIMVVTPVVPSSLSPAhcTVSPGVTTATTTFPVTVESTSVAPSTVSAPSQTRANEPASSPPAiTV 1679
Cdd:PHA03247  2688 ARPTVGSLTSLADPPPPPPTPEPAPHALVSA--TPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT-TA 2764

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1680 TGASATPGINTSTTSSPATPTATVNVTKATVIAAPVPT--LSLPTVVTAPTITCPViTTSPSTVVLTTAVATSVVTTPAS 1757
Cdd:PHA03247  2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWdpADPPAAVLAPAAALPP-AASPAGPLPPPTSAQPTAPPPPP 2843

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1758 SVSSVPIILSGvKSAPSlAPKREDATPQaqalnktPPKISPGAEKRvgPRLLLIPVPQTSPALRPLnnvQLPQKQrmiLQ 1837
Cdd:PHA03247  2844 GPPPPSLPLGG-SVAPG-GDVRRRPPSR-------SPAAKPAAPAR--PPVRRLARPAVSRSTESF---ALPPDQ---PE 2906

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1838 PLRSPGgvnlfrhpngqiiqlVPLQHFRAPGAQPNAQPNVQQPVMFRNPGSVVGIRLPAPAKHPEPPVSSASSVSSSVSS 1917
Cdd:PHA03247  2907 RPPQPQ---------------APPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGR 2971

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024506736 1918 TPPVTNATVQTAGPKSSSVSTPATQASSVSPSVTSYVSQAGtLTLKISPPAAS 1970
Cdd:PHA03247  2972 VAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLA-LHEETDPPPVS 3023
PTZ00121 super family cl31754
MAEBL; Provisional
 2194-2646 7.55e-06

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.07  E-value: 7.55e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2194 KDQETAQL--KNHGKEGIHAEWEDKPAKEQEGEVQAHMKENNKVGSRQSQKQQDTQLENKKEQTGTELPQNKKEFQDGPV 2271
Cdd:PTZ00121  1237 KDAEEAKKaeEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKK 1316

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2272 QPEVEKKECKASAEAESLR---EKKTSKSEISSAEEQHNAlgDKQVVSTEEGKTNVAMQEDSKNKEQGAVDSQEEIKTVE 2348
Cdd:PTZ00121  1317 ADEAKKKAEEAKKKADAAKkkaEEAKKAAEAAKAEAEAAA--DEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKAD 1394

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2349 DTVIHANSSWSKISSIAPASENKsetdNKADRSDKSvfmVTEQKAQESRHHKKSSTPNTDTTDYMEEEEEEDDDEDEKTD 2428
Cdd:PTZ00121  1395 EAKKKAEEDKKKADELKKAAAAK----KKADEAKKK---AEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAE 1467

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2429 DS--ADEMLDGASDFSSEEEI-----DVEKVFQDACEYSEDDEQVD-IETVEEL--SEKINIARLKATAANIRPSKEKYH 2498
Cdd:PTZ00121  1468 EAkkADEAKKKAEEAKKADEAkkkaeEAKKKADEAKKAAEAKKKADeAKKAEEAkkADEAKKAEEAKKADEAKKAEEKKK 1547

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2499 A---RNSSDEKLSESPTKQnppvwSRRQKSEEEAFAHYRQTHTANERRRrnemrdlfEKLKRALGLHSLPKVSKCYILKQ 2575
Cdd:PTZ00121  1548 AdelKKAEELKKAEEKKKA-----EEAKKAEEDKNMALRKAEEAKKAEE--------ARIEEVMKLYEEEKKMKAEEAKK 1614

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024506736 2576 ALDEiqglTDQADKLtgqkcilaRKQDTLIRKVSILSGKTEEVV-----LKKLEYMYAKQKAVEAQKKKKNVQSTE 2646
Cdd:PTZ00121  1615 AEEA----KIKAEEL--------KKAEEEKKKVEQLKKKEAEEKkkaeeLKKAEEENKIKAAEEAKKAEEDKKKAE 1678
 
Name Accession Description Interval E-value
T-box_MGA-like cd20195
DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known ...
 75-260 3.87e-138

DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known as MGAP, MAX dimerization protein, MAD5, MXD5) is a dual-specificity transcription factor that regulates the expression of both, MAX-network and T-box family target genes. MGA functions as a repressor or an activator; it binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence. Its function is activated by heterodimerization with MAX. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410321  Cd Length: 186  Bit Score: 428.78  E-value: 3.87e-138
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLG 154
Cdd:cd20195      1 ITVTLENNSMWNEFYRCGTEMILTKQGRRMFPYCRFRISGLDPDRNYILVMDISPVDNFRYRWNGRWWEPSGKAEPHVLG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  155 RVFIHPESPSTGQYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPADKATEVIQLNGPDVHTFTFPQTEFF 234
Cdd:cd20195     81 RVFIHPESPATGRHWMDQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHVVPADKEVDVIQLNGPDVHTFTFPQTEFF 160

                          170       180
                   ....*....|....*....|....*.
gi 2024506736  235 AVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20195    161 AVTAYQNKQITQLKIDYNPFAKGFRE 186
T-box pfam00907
T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box ...
 77-260 1.45e-107

T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.


Pssm-ID: 459990  Cd Length: 182  Bit Score: 341.08  E-value: 1.45e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   77 VTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLGRV 156
Cdd:pfam00907    1 VSLENKELWKKFHELGTEMIITKSGRRMFPTLKVSVSGLDPNAKYSVLLDIVPVDDKRYKFHNGKWVVAGKAEPHSPPRV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  157 FIHPESPSTGQYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPAdkATEVIQLNGPDVHTFTFPQTEFFAV 236
Cdd:pfam00907   81 YIHPDSPATGSHWMKQPVSFDKLKLTNNKEDKNGHIILNSMHKYQPRLHIVRV--GGDEPSLPEENVKTFVFPETEFIAV 158

                          170       180
                   ....*....|....*....|....
gi 2024506736  237 TAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:pfam00907  159 TAYQNEEITQLKIDNNPFAKGFRD 182
TBOX smart00425
Domain first found in the mice T locus (Brachyury) protein;
75-264 1.93e-88

Domain first found in the mice T locus (Brachyury) protein;


Pssm-ID: 214656  Cd Length: 190  Bit Score: 286.86  E-value: 1.93e-88
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736    75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLG 154
Cdd:smart00425    1 IKVSLEDKELWRKFHELGTEMIVTKSGRRMFPTLKYKVSGLDPNALYSVLMDLVPVDDKRYKFNNGKWVVAGKAEPHMPS 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   155 RVFIHPESPSTGQYWMHQPVSFYKLKLTNNTLDQEGH--IILHSMHRYLPRLHLVPADKATEVIQlngPDVHTFTFPQTE 232
Cdd:smart00425   81 RVYVHPDSPATGAHWMKQPVSFDKVKLTNNQSDKNGHlqIILNSMHKYQPRLHIVEVDDISKEIL---SQFKTFVFPETQ 157

                           170       180       190
                    ....*....|....*....|....*....|..
gi 2024506736   233 FFAVTAYQNIQITQLKIDYNPFAKGFRDDGLN 264
Cdd:smart00425  158 FIAVTAYQNQKITKLKIDNNPFAKGFRDQGRR 189
bHLHzip_MGA cd18911
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and ...
 2534-2597 5.24e-22

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins; MGA, also termed MAX dimerization protein 5 (MAD5), is a dual specificity T-box/ bHLHzip transcription factor that regulates the expression of both Max-network and T-box family target genes. It contains a Myc-like bHLHZip motif and requires heterodimerization with Max for binding to the preferred Myc-Max-binding site CACGTG. In addition to the bHLHZip domain, MGA harbors a second DNA-binding domain, the T-box or T-domain. It thus binds the preferred Brachyury-binding sequence and represses transcription of reporter genes containing promoter-proximal Brachyury-binding sites.


Pssm-ID: 381481  Cd Length: 65  Bit Score: 91.77  E-value: 5.24e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024506736 2534 RQTHTANERRRRNEMRDLFEKLKRALGLHSLPKVSKCYILKQALDEIQGLTDQADKLTGQKCIL 2597
Cdd:cd18911      1 RRTHTANERRRRNEMRDLFEKLKRTLGLHNLPKVSKYYILKQAFEEIQGLTDQADRLIGQKTLL 64
MGA_dom pfam16059
MGA, conserved domain; This domain can be found in the MAX gene-associated protein (Mga), ...
 1028-1069 2.81e-14

MGA, conserved domain; This domain can be found in the MAX gene-associated protein (Mga), which is a dual-specificity transcription factor that contains both a bHLHZip domain and a T-box domain and is able to bind to and regulate transcriptional targets through both E-box sites as well as T-box-binding elements (TBEs).


Pssm-ID: 464998  Cd Length: 51  Bit Score: 69.44  E-value: 2.81e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2024506736 1028 RRRAPPCNNDFCRLGCICASLA-LEKRQPTHCRRPDCMFGCTC 1069
Cdd:pfam16059    2 KDAKKPCDKDYCQLGCVCDSLAgTRPPKREHCGRADCVLGCVC 44
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1526-1970 1.38e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 1.38e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1526 SSASGTPSVQVPTTSAPKT-TSSISTTSNPSVTTLKALIPPLRQIAARPSPGGVFTKFVMNKVGALQQ-----KIPSVST 1599
Cdd:PHA03247  2608 PRGPAPPSPLPPDTHAPDPpPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQassppQRPRRRA 2687

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1600 CQPLSGPQKFSINPTPIMVVTPVVPSSLSPAhcTVSPGVTTATTTFPVTVESTSVAPSTVSAPSQTRANEPASSPPAiTV 1679
Cdd:PHA03247  2688 ARPTVGSLTSLADPPPPPPTPEPAPHALVSA--TPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT-TA 2764

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1680 TGASATPGINTSTTSSPATPTATVNVTKATVIAAPVPT--LSLPTVVTAPTITCPViTTSPSTVVLTTAVATSVVTTPAS 1757
Cdd:PHA03247  2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWdpADPPAAVLAPAAALPP-AASPAGPLPPPTSAQPTAPPPPP 2843

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1758 SVSSVPIILSGvKSAPSlAPKREDATPQaqalnktPPKISPGAEKRvgPRLLLIPVPQTSPALRPLnnvQLPQKQrmiLQ 1837
Cdd:PHA03247  2844 GPPPPSLPLGG-SVAPG-GDVRRRPPSR-------SPAAKPAAPAR--PPVRRLARPAVSRSTESF---ALPPDQ---PE 2906

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1838 PLRSPGgvnlfrhpngqiiqlVPLQHFRAPGAQPNAQPNVQQPVMFRNPGSVVGIRLPAPAKHPEPPVSSASSVSSSVSS 1917
Cdd:PHA03247  2907 RPPQPQ---------------APPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGR 2971

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024506736 1918 TPPVTNATVQTAGPKSSSVSTPATQASSVSPSVTSYVSQAGtLTLKISPPAAS 1970
Cdd:PHA03247  2972 VAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLA-LHEETDPPPVS 3023
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1598-1787 2.01e-07

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 56.51  E-value: 2.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1598 STCQPLSGPQKFSIN-PTPIMVVTPVVPSSLSPAHCTVSPgvttatttfpvtvesTSVAPSTVSAPSQTRANEPASSPPA 1676
Cdd:pfam17823  129 SLPAAIAALPSEAFSaPRAAACRANASAAPRAAIAAASAP---------------HAASPAPRTAASSTTAASSTTAASS 193

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1677 ITVTGASATPgintsTTSSPATPTATVNVTKATVIAAPVpTLSLPTVVTAP-TITCPVITTSPSTVVLTTAVATSVVTTP 1755
Cdd:pfam17823  194 APTTAASSAP-----ATLTPARGISTAATATGHPAAGTA-LAAVGNSSPAAgTVTAAVGTVTPAALATLAAAAGTVASAA 267

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 2024506736 1756 ASSVSSVPI--ILSGVKSAPSLAPKREDAT---PQAQ 1787
Cdd:pfam17823  268 GTINMGDPHarRLSPAKHMPSDTMARNPAApmgAQAQ 304
PTZ00121 PTZ00121
MAEBL; Provisional
 2194-2646 7.55e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.07  E-value: 7.55e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2194 KDQETAQL--KNHGKEGIHAEWEDKPAKEQEGEVQAHMKENNKVGSRQSQKQQDTQLENKKEQTGTELPQNKKEFQDGPV 2271
Cdd:PTZ00121  1237 KDAEEAKKaeEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKK 1316

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2272 QPEVEKKECKASAEAESLR---EKKTSKSEISSAEEQHNAlgDKQVVSTEEGKTNVAMQEDSKNKEQGAVDSQEEIKTVE 2348
Cdd:PTZ00121  1317 ADEAKKKAEEAKKKADAAKkkaEEAKKAAEAAKAEAEAAA--DEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKAD 1394

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2349 DTVIHANSSWSKISSIAPASENKsetdNKADRSDKSvfmVTEQKAQESRHHKKSSTPNTDTTDYMEEEEEEDDDEDEKTD 2428
Cdd:PTZ00121  1395 EAKKKAEEDKKKADELKKAAAAK----KKADEAKKK---AEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAE 1467

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2429 DS--ADEMLDGASDFSSEEEI-----DVEKVFQDACEYSEDDEQVD-IETVEEL--SEKINIARLKATAANIRPSKEKYH 2498
Cdd:PTZ00121  1468 EAkkADEAKKKAEEAKKADEAkkkaeEAKKKADEAKKAAEAKKKADeAKKAEEAkkADEAKKAEEAKKADEAKKAEEKKK 1547

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2499 A---RNSSDEKLSESPTKQnppvwSRRQKSEEEAFAHYRQTHTANERRRrnemrdlfEKLKRALGLHSLPKVSKCYILKQ 2575
Cdd:PTZ00121  1548 AdelKKAEELKKAEEKKKA-----EEAKKAEEDKNMALRKAEEAKKAEE--------ARIEEVMKLYEEEKKMKAEEAKK 1614

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024506736 2576 ALDEiqglTDQADKLtgqkcilaRKQDTLIRKVSILSGKTEEVV-----LKKLEYMYAKQKAVEAQKKKKNVQSTE 2646
Cdd:PTZ00121  1615 AEEA----KIKAEEL--------KKAEEEKKKVEQLKKKEAEEKkkaeeLKKAEEENKIKAAEEAKKAEEDKKKAE 1678
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
1618-1760 2.31e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 50.14  E-value: 2.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1618 VVTPVVPSSLSPAHCTVSPGVTTATTTFPVTVESTSVA-PSTVSAPSQTRANEPASSPPAITVTGASATPGINTSTTSSP 1696
Cdd:COG3469     65 AASSTAATSSTTSTTATATAAAAAATSTSATLVATSTAsGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSA 144

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024506736 1697 ATPTATVNVTK---ATVIAAPVPTLSLPTVVTAPTITCPVITTSPSTVVLTTAVATSVVTTPASSVS 1760
Cdd:COG3469    145 GSTTTTTTVSGtetATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPG 211
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 2054-2477 2.99e-04

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 46.55  E-value: 2.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2054 HSEETEVAQSEASVSGGKQEEKEVSVNQPNNVEESVSGTVTPVKNSTALEALEQESKVLQGSGDDGPSLQNDVSTDVISS 2133
Cdd:COG5271    323 EIATADELAAADDEDDDDSAAEDAAEEAATAEDSAAEDTQDAEDEAAGEAADESEGADTDAAADEADAAADDSADDEEAS 402

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2134 DHSYISEKPSDEENEAVTEEKEDSVCSENVGAVSTNSETvcesldhslvAPLNDAHPQSLKDQE-TAQLKNHGKEGIHAE 2212
Cdd:COG5271    403 ADGGTSPTSDTDEEEEEADEDASAGETEDESTDVTSAED----------DIATDEEADSLADEEeEAEAELDTEEDTESA 472

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2213 WEDKPAKEQEGEVQAHMKENNKVGSRQSQKQQDTqlENKKEQTGTELPQNKKEFQDGPVQPEVEKKECKASAEAESLREK 2292
Cdd:COG5271    473 EEDADGDEATDEDDASDDGDEEEAEEDAEAEADS--DELTAEETSADDGADTDAAADPEDSDEDALEDETEGEENAPGSD 550

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2293 KTSKSEISSAEEQHNALGDKQVVSTEEGKTNvamqeDSKNKEQGAVDSQEEIKTVEDTVIHANSswskissiAPASENKS 2372
Cdd:COG5271    551 QDADETDEPEATAEEDEPDEAEAETEDATEN-----ADADETEESADESEEAEASEDEAAEEEE--------ADDDEADA 617

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2373 ETDNKADRSDKSVFMVTEQKAQESRHHKKSSTPNTDTTDYMEEE----EEEDDDEDEKTDDSADEMLDGASDFSSEEEID 2448
Cdd:COG5271    618 DADGAADEEETEEEAAEDEAAEPETDASEAADEDADAETEAEASadesEEEAEDESETSSEDAEEDADAAAAEASDDEEE 697

                          410       420
                   ....*....|....*....|....*....
gi 2024506736 2449 VEKVFQDACEYSEDDEQVDIETVEELSEK 2477
Cdd:COG5271    698 TEEADEDAETASEEADAEEADTEADGTAE 726
SP4_N cd22536
N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins ...
 1724-1895 6.76e-04

N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Human SP4 is a risk gene of multiple psychiatric disorders including schizophrenia, bipolar disorder, and major depression. SP4 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP4.


Pssm-ID: 411773 [Multi-domain]  Cd Length: 623  Bit Score: 45.29  E-value: 6.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1724 VTAPTITCPVITTSPSTVVLTTAVATSVVTTPASSVSSVPIILSGvkSAPSLAPKREDATPQAQALNKTPPKISPGAEKR 1803
Cdd:cd22536    276 LVSTPITTASVSTMPESPSSSTTCTTTASTSLTSSDTLVSSAETG--QYASTAASSERTEEEPQTSAAESEAQSSSQLQS 353

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1804 VGprllLIPVPQTSPALRPLNNVQLPQKQRMILQplrspggvnlfrHPNGQIIQLVPLQHFRAPGAQP------NAQPNV 1877
Cdd:cd22536    354 NG----LQNVQDQSNSLQQVQIVGQPILQQIQIQ------------QPQQQIIQAIQPQSFQLQSGQTiqtiqqQPLQNV 417

                          170
                   ....*....|....*...
gi 2024506736 1878 qQPVMFRNPGSVVgIRLP 1895
Cdd:cd22536    418 -QLQAVQSPTQVL-IRAP 433
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 2214-2475 4.78e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 42.68  E-value: 4.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2214 EDKPAKEQEGEvqahmkeNNKVGSRQSQKQQDTQLENKKEQTGtELPQNKKEFQDGPVQPEVEKKECKASAEAESLREKK 2293
Cdd:TIGR00927  648 EGERPTEAEGE-------NGEESGGEAEQEGETETKGENESEG-EIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEG 719

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2294 TSKSEISSAEEQHNALGDKQVVSTE-----EGKTNVAMQEDSKNKEQGAVDSQEEIKTVEDTVIHANSSWSKISSIAPAS 2368
Cdd:TIGR00927  720 ETEAEGTEDEGEIETGEEGEEVEDEgegeaEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDEGAEG 799

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2369 ENKSETDNKADRSDKSVFMVTEQKAQESRHHKKSSTP-NTDTTDymeeeeeedddeDEKTDDSADEMLDGASDFSSEEEI 2447
Cdd:TIGR00927  800 KVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQElNAENQG------------EAKQDEKGVDGGGGSDGGDSEEEE 867

                          250       260
                   ....*....|....*....|....*...
gi 2024506736 2448 DVEKVFQDACEYSEDDEQVDIETVEELS 2475
Cdd:TIGR00927  868 EEEEEEEEEEEEEEEEEEEEEENEEPLS 895
DUF612 pfam04747
Protein of unknown function, DUF612; This family includes several uncharacterized proteins ...
 2188-2413 5.48e-03

Protein of unknown function, DUF612; This family includes several uncharacterized proteins from Caenorhabditis elegans.


Pssm-ID: 282585 [Multi-domain]  Cd Length: 511  Bit Score: 42.36  E-value: 5.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2188 AHPQSLKDQETAQLKNHGK----EGIHAEWEDKPAKEQEGEVQAHMKENNKVGSRQSQKQQDT---QLENKKEQT----- 2255
Cdd:pfam04747   78 AQKQIAKDHEAEQKVNAKKaaekEARRAEAEAKKRAAQEEEHKQWKAEQERIQKEQEKKEADLkklQAEKKKEKAvkaek 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2256 GTELPQNKKEFQDGPVQPEVEKKEC-----------------KASAEAESLRE---------KKTSKSEISSAEEQHNAL 2309
Cdd:pfam04747  158 AEKAEKTKKASTPAPVEEEIVVKKVandrsaapapepktptnTPAEPAEQVQEitgkknkknKKKSESEATAAPASVEQV 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2310 GDKQVVSTEEGKTNVAMQEdSKNKEQGAVDSQEEIKTVEDTVIHAnsswsKISSIAPASENKSETDNKADRSDKSVFMVT 2389
Cdd:pfam04747  238 VEQPKVVTEEPHQQAAPQE-KKNKKNKRKSESENVPAASETPVEP-----VVETTPPASENQKKNKKDKKKSESEKVVEE 311

                          250       260
                   ....*....|....*....|....
gi 2024506736 2390 EQKAQESRHHKKSSTPNTDTTDYM 2413
Cdd:pfam04747  312 PVQAEAPKSKKPTADDNMDFLDFV 335
 
Name Accession Description Interval E-value
T-box_MGA-like cd20195
DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known ...
 75-260 3.87e-138

DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known as MGAP, MAX dimerization protein, MAD5, MXD5) is a dual-specificity transcription factor that regulates the expression of both, MAX-network and T-box family target genes. MGA functions as a repressor or an activator; it binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence. Its function is activated by heterodimerization with MAX. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410321  Cd Length: 186  Bit Score: 428.78  E-value: 3.87e-138
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLG 154
Cdd:cd20195      1 ITVTLENNSMWNEFYRCGTEMILTKQGRRMFPYCRFRISGLDPDRNYILVMDISPVDNFRYRWNGRWWEPSGKAEPHVLG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  155 RVFIHPESPSTGQYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPADKATEVIQLNGPDVHTFTFPQTEFF 234
Cdd:cd20195     81 RVFIHPESPATGRHWMDQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHVVPADKEVDVIQLNGPDVHTFTFPQTEFF 160

                          170       180
                   ....*....|....*....|....*.
gi 2024506736  235 AVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20195    161 AVTAYQNKQITQLKIDYNPFAKGFRE 186
T-box pfam00907
T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box ...
 77-260 1.45e-107

T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.


Pssm-ID: 459990  Cd Length: 182  Bit Score: 341.08  E-value: 1.45e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   77 VTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLGRV 156
Cdd:pfam00907    1 VSLENKELWKKFHELGTEMIITKSGRRMFPTLKVSVSGLDPNAKYSVLLDIVPVDDKRYKFHNGKWVVAGKAEPHSPPRV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  157 FIHPESPSTGQYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPAdkATEVIQLNGPDVHTFTFPQTEFFAV 236
Cdd:pfam00907   81 YIHPDSPATGSHWMKQPVSFDKLKLTNNKEDKNGHIILNSMHKYQPRLHIVRV--GGDEPSLPEENVKTFVFPETEFIAV 158

                          170       180
                   ....*....|....*....|....
gi 2024506736  237 TAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:pfam00907  159 TAYQNEEITQLKIDNNPFAKGFRD 182
T-box_TBX4_5-like cd20189
DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins; This ...
 75-260 1.99e-89

DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins; This subfamily includes the T-box transcription factors TBX4 and TBX5 which play important roles in vertebrate limb and heart development, and in lung and trachea development. TBX4 is needed for normal skeletal and muscular hindlimb development and is involved in super-enhancer-driven transcriptional programs underlying features specific to lung fibroblasts. TBX5 plays a role in regulating cardiac conduction system function, and in coordinating forelimb muscle pattern. Mutations in human TBX5 and TBX4 are associated with Holt-Oram syndrome and Small Patella syndrome, respectively. Both syndromes are characterized by limb defects in addition to other abnormalities. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410315  Cd Length: 185  Bit Score: 289.33  E-value: 1.99e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLG 154
Cdd:cd20189      1 IKVFLENRELWQKFHEVGTEMIITKAGRRMFPSIKVKVTGLNPKTKYILLMDIVPADDHRYKFHDSEWVVAGKAEPAMPG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  155 RVFIHPESPSTGQYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPADKaTEVIQLNGPDVHTFTFPQTEFF 234
Cdd:cd20189     81 RLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDQFGHIILNSMHKYQPRIHIVQADD-NNAFGSKNTAFSTHVFPETAFI 159

                          170       180
                   ....*....|....*....|....*.
gi 2024506736  235 AVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20189    160 AVTAYQNHQITQLKIENNPFAKGFRG 185
TBOX smart00425
Domain first found in the mice T locus (Brachyury) protein;
75-264 1.93e-88

Domain first found in the mice T locus (Brachyury) protein;


Pssm-ID: 214656  Cd Length: 190  Bit Score: 286.86  E-value: 1.93e-88
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736    75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLG 154
Cdd:smart00425    1 IKVSLEDKELWRKFHELGTEMIVTKSGRRMFPTLKYKVSGLDPNALYSVLMDLVPVDDKRYKFNNGKWVVAGKAEPHMPS 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   155 RVFIHPESPSTGQYWMHQPVSFYKLKLTNNTLDQEGH--IILHSMHRYLPRLHLVPADKATEVIQlngPDVHTFTFPQTE 232
Cdd:smart00425   81 RVYVHPDSPATGAHWMKQPVSFDKVKLTNNQSDKNGHlqIILNSMHKYQPRLHIVEVDDISKEIL---SQFKTFVFPETQ 157

                           170       180       190
                    ....*....|....*....|....*....|..
gi 2024506736   233 FFAVTAYQNIQITQLKIDYNPFAKGFRDDGLN 264
Cdd:smart00425  158 FIAVTAYQNQKITKLKIDNNPFAKGFRDQGRR 189
T-box_VegT-like cd20197
DNA-binding domain of Xenopus VegT and related T-box proteins; VegT, (also known as Antipodean, ...
 75-260 3.91e-88

DNA-binding domain of Xenopus VegT and related T-box proteins; VegT, (also known as Antipodean, Brat and Xombi), is a T-box transcription factor required in early Xenopus embryos for the formation of both, the mesoderm and endoderm germ layers. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410323  Cd Length: 183  Bit Score: 285.58  E-value: 3.91e-88
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLG 154
Cdd:cd20197      1 VRASLEDQDLWKKFHQIGTEMIITKSGRRMFPQCKIRVSGLLPYAKYVMLVDFVPVDNFRYKWNKDQWEVAGKAEPQPPC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  155 RVFIHPESPSTGQYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPADkatEVIQLNGPDVHTFTFPQTEFF 234
Cdd:cd20197     81 RTYVHPDSPAPGSHWMKQPISFQKLKLTNNTLDQHGHIILHSMHRYQPRFHIVQAD---DLFNVRWSLFQVFSFPETVFT 157

                          170       180
                   ....*....|....*....|....*.
gi 2024506736  235 AVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20197    158 AVTAYQNEKITKLKIDNNPFAKGFRE 183
T-box_TBX6_VegT-like cd20190
DNA-binding domain of T-box transcription factor 6, VegT and related T-box proteins; This ...
 75-260 3.19e-87

DNA-binding domain of T-box transcription factor 6, VegT and related T-box proteins; This subfamily includes the transcriptional regulators TBX6 and VegT. TBX6 plays an essential role in the fate determination of axial stem to become either neural or mesodermal. It also plays an essential role in the regulation of left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. VegT (also known as Antipodean, Brat and Xombi) is required in early Xenopus embryos for the formation of both the mesoderm and endoderm germ layers. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved 1DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410316  Cd Length: 183  Bit Score: 282.93  E-value: 3.19e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLG 154
Cdd:cd20190      1 VSLSLEDRELWKEFSSVGTEMIITKSGRRMFPACKVSVTGLDPEAKYLFLLDVVPVDNARYKWNKRRWEPSGKAEPHLPD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  155 RVFIHPESPSTGQYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPADkatEVIQLNGPDVHTFTFPQTEFF 234
Cdd:cd20190     81 RVYIHPDSPAPGAHWMRQPISFHKLKLTNNTLDPHGHLILHSMHKYQPRIHLVQSA---DLCSQHWGGMASFRFPETTFI 157

                          170       180
                   ....*....|....*....|....*.
gi 2024506736  235 AVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20190    158 AVTAYQNPQITKLKIAANPFAKGFRE 183
T-box_TBX6 cd20196
DNA-binding domain of T-box transcription factor 6, and related T-box proteins; TBX6 is a ...
 75-260 1.44e-81

DNA-binding domain of T-box transcription factor 6, and related T-box proteins; TBX6 is a T-box transcription factor which plays an essential role in the fate determination of axial stem to become either neural or mesodermal. It also plays an essential role in the regulation of left/right patterning in mouse embryos, through effects on nodal cilia and perinodal signaling. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410322  Cd Length: 182  Bit Score: 266.73  E-value: 1.44e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLG 154
Cdd:cd20196      1 VRMSLENAELWKQFSSVGTEMIITKAGRRMFPQLRVSVSGLDPEARYLLLLDVVPVDGSRYRWQGNSWEASGKAEPRLPD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  155 RVFIHPESPSTGQYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPADKatevIQLNGPDVHTFTFPQTEFF 234
Cdd:cd20196     81 RVYIHPDSPATGAHWMRQPISFHRAKLTNNTLDPHGHIILHSMHRYQPRVHVVRARD----VLSWGGGCASFTFPETQFI 156

                          170       180
                   ....*....|....*....|....*.
gi 2024506736  235 AVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20196    157 TVTAYQNPKITQLKINSNPFAKGFRE 182
T-box_TBX2_3-like cd20188
DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins; This ...
 75-260 2.98e-81

DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins; This subfamily includes the T-box transcription factors TBX2 and TBX3 and similar proteins. TBX2 is an oncogenic transcription factor implicated in developmental processes, including coordinating cell fate, patterning and morphogenesis of a wide range of tissues and organs. It is overexpressed in several cancers, including melanoma and breast, and plays a key role during cardiac development. TBX2 is a negative regulator of promyelocytic leukemia protein (PML) function in cellular senescence, and it interacts with HP1 to recruit a repression complex to EGR1-responsive promoters to drive the proliferation of breast cancer cells. TBX3 has also been implicated in oncogenesis in breast cancer and melanoma. The tbx3 gene is downregulated by PML. TBX3 directly represses TBX2 under the control of the PRC2 complex in skeletal muscle and rhabdomyosarcoma. Also included in this family is the Drosophila melanogaster optomotor-blind protein (Omb, also known as lethal(1)optomotor-blind, or L(1)omb, or protein bifid) which controls many developmental processes such as wing, eye, and abdominal tergites and optic lobes, and induces epithelial cell migration and extrusion in vivo. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410314  Cd Length: 185  Bit Score: 265.83  E-value: 2.98e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLG 154
Cdd:cd20188      3 PKVELEAKDLWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPK 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  155 RVFIHPESPSTGQYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVpadKATEVIQLNGPDVHTFTFPQTEFF 234
Cdd:cd20188     83 RMYIHPDSPSTGEQWMQKVVSFHKLKLTNNISDKHGFTILNSMHKYQPRFHIV---RANDILKLPYSTFRTYVFKETEFI 159

                          170       180
                   ....*....|....*....|....*.
gi 2024506736  235 AVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20188    160 AVTAYQNEKITQLKIDNNPFAKGFRD 185
T-box cd00182
DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient ...
 75-252 6.65e-81

DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the family is Brachyury (also known as TBXT, or T). Members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns. The T-box factors in Caenorhabditis elegans have evolved very differently than those in other organisms; its genome contains 22 T-box genes which encode factors which are diverse in DNA-binding specificity, function and sequence, and only 3 of these factors fall into the conserved T-box subfamilies.


Pssm-ID: 410312  Cd Length: 176  Bit Score: 264.46  E-value: 6.65e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHV-L 153
Cdd:cd00182      1 ITVSLRNEELWKKFHELGTEMIVTKSGRRMFPTLEYSVSGLDPNKLYSVSLHFERVDNKRYKFNNGKWVPSGKAEPPPeP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  154 GRVFIHPESPSTGQYWMHQPVSFYKLKLTNNTLD-QEGHIILHSMHRYLPRLHLVpadKATEVIQLNGPdVHTFTFPQTE 232
Cdd:cd00182     81 SRIYVHPDGPQTGSFWMKKGVSFDKVKITNNKEDkKEGHILLHSMHKYIPVLTIY---EVDDNGLLSKL-VKEFRFPETE 156

                          170       180
                   ....*....|....*....|
gi 2024506736  233 FFAVTAYQNIQITQLKIDYN 252
Cdd:cd00182    157 FIAVTAYQNDEITQLKIDNN 176
T-box_Drosocross-like cd20681
DNA-binding domain of Drosophila Dorsocross and related T-box proteins; Drosophila Dorsocross ...
 75-260 7.33e-79

DNA-binding domain of Drosophila Dorsocross and related T-box proteins; Drosophila Dorsocross (Doc) includes three Dorsocross paralogs, Doc1-3. These are key cardiogenic T-box transcription factors during specification and differentiation of heart cells. Drosophila Doc also functions in caudal visceral mesoderm development, and modulates Notch signaling in the developing Drosophila eye by regulating the expression of Delta in the eye imaginal discs. Doc also functions in the morphogenesis of epithelial tissues: in Drosophila, which possesses a single extraembryonic (EE) membrane, it is essential for EE epithelia tissue maintenance while in Tribolium castaneum, which has 2 EE membranes, Doc plays a major role in EE morphogenetic events throughout development without affecting EE tissue specificity or maintenance. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410332  Cd Length: 186  Bit Score: 259.19  E-value: 7.33e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKWNG-RWWEPSGKAEP--H 151
Cdd:cd20681      1 VKVTLKNRDLWQQFHREGTEMIITKSGRRMFPSLRLSVSGLEPDARYCVLLEMVLASDCRFKYSGnGGWVPAGGAEPqpP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  152 VLGRVFIHPESPSTGQYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPADKATEVIQlnGPDvHTFTFPQT 231
Cdd:cd20681     81 LPRRIYIHPDSPATGDHWMSQPISFSKVKLTNNTLDPQGNIVLTSMHKYQPRIHIVRCSDTLALPW--APT-ASFTFPET 157

                          170       180
                   ....*....|....*....|....*....
gi 2024506736  232 EFFAVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20681    158 EFIAVTAYQNERITKLKIDNNPFAKGFRE 186
T-box_TBXT_TBX19-like cd20192
DNA-binding domain of T-box transcription factor T, T-box transcription factor 19 and related ...
 75-260 5.10e-78

DNA-binding domain of T-box transcription factor T, T-box transcription factor 19 and related T-box proteins; Tbx19 (also known as Tpit) is a T-box factor restricted to two pituitary (pro-opiomelanocortin) POMC-expressing lineages, the corticotrophs and melanotrophs; it controls terminal differentiation of these lineages. TBX19 activates POMC gene transcription with the cooperation of another transcription factor Pitx1. TBXT, also known as Brachyury protein, or protein T, is a transcription factor needed for posterior mesoderm formation and differentiation as well as for the notochord development during embryogenesis. It binds to a 24 base-pair (bp) palindromic site (called the T site) and activates gene transcription when bound to such a site. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. TBXT is the founding member of the T-box family, members of which share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410318  Cd Length: 180  Bit Score: 256.42  E-value: 5.10e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKW-NGRWWePSGKAEPHVL 153
Cdd:cd20192      1 IRVTLEDRELWKKFHSLTNEMIVTKSGRRMFPVLKVSVSGLDPNAMYSVLLDFVQVDNHRWKYvNGEWV-PGGKAEPPPP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  154 GRVFIHPESPSTGQYWMHQPVSFYKLKLTNNtLDQEGHIILHSMHRYLPRLHLVPADKateviQLNGPDVHTFTFPQTEF 233
Cdd:cd20192     80 SSVYVHPDSPNFGAHWMKGPVSFSKVKLTNK-PNGEGQIMLNSLHKYEPRVHIVRVGS-----NNHERLVSTFSFPETQF 153

                          170       180
                   ....*....|....*....|....*..
gi 2024506736  234 FAVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20192    154 IAVTAYQNEEITALKIKYNPFAKAFLD 180
T-box_TBX1_10-like cd20187
DNA-binding domain of T-box transcription factor 1 and 10, and related T-box proteifactors; ...
 74-260 1.07e-77

DNA-binding domain of T-box transcription factor 1 and 10, and related T-box proteifactors; This subfamily includes TBX1 and TBX10. TBX1 is a T-box transcription factor which plays an important role in heart development and has been implicated in DiGeorge or 22q11.2 deletion syndrome. This syndrome is associated with various types of cardiac outflow tract (OFT) and vascular defects. Wnt5a is regulated by TBX1 in the second heart field (SHF). TBX1 is required to maintain the integrity of extracellular matrix-cell interactions in the SHF and this interaction is critical for cardiac (OFT) development. TBX10 is a putative T-box transcription factor. Diseases associated with TBX10 include Isolated Cleft Lip and Cleft Lip/cleft lip with or without cleft palate. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410313  Cd Length: 189  Bit Score: 255.81  E-value: 1.07e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   74 GITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKW--NGRWWEPSGKAEPH 151
Cdd:cd20187      1 NVTVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKIFGMDPMADYMLMMDFVPVDDKRYRYafHSSSWLVAGKADPA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  152 VLGRVFIHPESPSTGQYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPADKATEVIQLNGPDVHTFTFPQT 231
Cdd:cd20187     81 MPGRIHVHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDPRKDSENSAEENFKTFIFPET 160

                          170       180
                   ....*....|....*....|....*....
gi 2024506736  232 EFFAVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20187    161 KFTAVTAYQNHRITQLKIASNPFAKGFRD 189
T-box_TBX20-like cd20193
DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a ...
 75-260 2.85e-73

DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a T-box transcriptional factor which functions in embryonic development and its deficiency is associated with congenital heart disease. It acts both as a transcriptional activator and a repressor required for cardiac development, and has key roles in maintaining the functional and structural phenotypes in the adult heart. The TBX20-cardiac transcription factor CASZ1 protein complex is protective against dilated cardiomyopathy and is essential for maintaining cardiac homeostasis. TBX20 has also been shown to regulate angiogenesis through the PROK2-PROKR1 (prokineticin receptor 1) pathway and is involved in both, pathological and developmental, angiogenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410319  Cd Length: 190  Bit Score: 243.11  E-value: 2.85e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKW--NGRWWEPSGKAEPHV 152
Cdd:cd20193      1 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGVDPDAKYIVLMDIVPVDNKRYRYayHRSSWLVAGKADPPL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  153 LGRVFIHPESPSTGQYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPADKAT-EVIQLNGPDVHTFTFPQT 231
Cdd:cd20193     81 PARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDKHGHIILNSMHKYQPRVHIVKKKDHTaSLVNLKSEEFRTFIFPET 160

                          170       180
                   ....*....|....*....|....*....
gi 2024506736  232 EFFAVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20193    161 VFTAVTAYQNQLITKLKIDSNPFAKGFRD 189
T-box_TBX15_18_22-like cd20191
DNA-binding domain of T-box transcription factor 15, 18 and 22, and related T-box proteins; ...
 75-260 8.43e-72

DNA-binding domain of T-box transcription factor 15, 18 and 22, and related T-box proteins; This subfamily includes the transcriptional regulators TBX15, TBX18 and TBX22 which are involved in various developmental processes. TBX15 (also known as TBX14) plays an important role in the development of the skeleton of the limb, vertebral column and head, possibly through its control of the number of mesenchymal precursor cells and chondrocytes; it also plays a role in the differentiation of brown and brite adipocytes. TBX18 is involved in the developmental processes of a variety of tissues and organs, including the ureter, vertebral column. epicardium and coronary vessels; it is important for the development of the head portion of the sino atrial node (SAN). Mutations in the T-box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome), and associated with cleft lip and palate, and tooth agenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410317  Cd Length: 194  Bit Score: 239.41  E-value: 8.43e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKW--NGRWWEPSGKAEPHV 152
Cdd:cd20191      3 IQVELQGSELWKRFHDIGTEMIITKAGRRMFPAIRVKVSGLDPHAQYIVAMDIVPVDNKRYRYvyHSSKWMVAGNADAPV 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  153 LGRVFIHPESPSTGQYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPADKATEV----IQLNGPDVHTFTF 228
Cdd:cd20191     83 PPRVYIHPDSPASGETWMRQVVSFDKLKLTNNEMDDQGHIILHSMHKYQPRVHVIRKDSSTDLspkkPVPPGEGVKTFSF 162

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2024506736  229 PQTEFFAVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20191    163 PETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 194
T-box-like cd20682
T-box DNA-binding domain; uncharacterized subfamily; The T-box family is an ancient group that ...
 75-260 4.21e-70

T-box DNA-binding domain; uncharacterized subfamily; The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors.


Pssm-ID: 410333  Cd Length: 191  Bit Score: 234.21  E-value: 4.21e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKW---NGRwWEPSGKAEPH 151
Cdd:cd20682      1 IQVELCSRELWLQFHNLGNEMIITKAGRRMFPALKVKLTGLDPDKLYIVWVDIVPVDSNRYRYvyhSSK-WVVAGSGDVL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  152 VLGRVFIHPESPSTGQYWMHQPVSFYKLKLTNN-TLDQEGHIILHSMHRYLPRLHL--VPADKATEVIQLNGPDVHTFTF 228
Cdd:cd20682     80 PPANRYIHPDSPASGKYWMSQIVSFDKLKLTNNkEPKQKGQISLHSMHKYQPRIHIqpVEDDGRNVEKAINSSKALSFEF 159

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2024506736  229 PQTEFFAVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20682    160 PETSFITVTAYQNQQITKLKIASNPFAKGFRD 191
T-box_TBR1_2_21-like cd20194
DNA-binding domain of T-box brain protein 1 and 2, T-box transcription factor 21 and related ...
 77-260 1.18e-68

DNA-binding domain of T-box brain protein 1 and 2, T-box transcription factor 21 and related T-box proteins; TBX21 (also known as T-cell-specific T-box transcription factor T-bet or transcription factor TBLYM) is a lineage-defining transcription factor which directs T helper type 1 (Th1) cell differentiation. This subfamily includes TBR1 (also known as T-brain-1, or TES-56), which is a neuron-specific transcription factor involved in forebrain development, and TBR2 (also known as Eomesodermin, Eomes, or T-brain-2), which is associated with neurogenesis, cardiogenesis and tumor immune response. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410320  Cd Length: 185  Bit Score: 229.67  E-value: 1.18e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   77 VTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLG-R 155
Cdd:cd20194      4 VYLCNRDLWLKFHQHQTEMIITKQGRRMFPTLSFNLSGLDPTAHYNVFVDMVLADPNHWKFQSGKWVPCGKAEGLPQGnR 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  156 VFIHPESPSTGQYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVpadkatEVIQLNGPD---VHTFTFPQTE 232
Cdd:cd20194     84 VYVHPDSPNTGAHWMKQEISFSKLKLTNNKGADQGMIVLNSMHKYQPRIHVI------EVGGNGPNEqrnLQTHSFPETQ 157

                          170       180
                   ....*....|....*....|....*...
gi 2024506736  233 FFAVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20194    158 FIAVTAYQNTDITQLKIDHNPFAKGFRD 185
T-box_TBX21 cd20203
DNA-binding domain of T-box transcription factor 21 and related T-box proteins; TBX21 (also ...
 75-260 9.61e-66

DNA-binding domain of T-box transcription factor 21 and related T-box proteins; TBX21 (also known as T-cell-specific T-box transcription factor T-bet or transcription factor TBLYM) is a lineage-defining transcription factor which directs T helper type 1 (Th1) cell differentiation. It initiates Th1 lineage development from naive T helper precursor cells both by initiating the Th1 genetic programs and by inhibiting the opposing Th2 and Th17 lineage-commitment programs. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410329  Cd Length: 191  Bit Score: 221.76  E-value: 9.61e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLG 154
Cdd:cd20203      2 LQVLLNNHPLWSKFHKHQTEMIITKQGRRMFPFLSFNLTGLDPTAHYNVYVDVVLADQHHWRYQGGKWVQCGKAEGNMPG 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  155 -RVFIHPESPSTGQYWMHQPVSFYKLKLTNN---TLDQEGHIILHSMHRYLPRLHLVPADKATEVIQLNGPDVHTFTFPQ 230
Cdd:cd20203     82 nRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNkgaSNNVTQMIVLQSLHKYQPRLHIVEVKEGETEEAYSSSKTHTFTFPE 161

                          170       180       190
                   ....*....|....*....|....*....|
gi 2024506736  231 TEFFAVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20203    162 TQFIAVTAYQNAEITQLKIDHNPFAKGFRD 191
T-box_TBX18_like cd20199
DNA-binding domain of T-box transcription factor 18 and related T-box proteins; TBX18 acts as ...
 75-260 3.74e-64

DNA-binding domain of T-box transcription factor 18 and related T-box proteins; TBX18 acts as a transcription repressor involved in the developmental processes of a variety of tissues and organs, including the ureter, vertebral column. epicardium and coronary vessels. TBX18 is important for the development of the head portion of the sino atrial node (SAN); SAN is the pacemaker region of the heart that initiates each heartbeat. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410325  Cd Length: 195  Bit Score: 217.22  E-value: 3.74e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKW--NGRWWEPSGKAEPHV 152
Cdd:cd20199      4 VRVDLQGADLWKRFHEIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYvyHSSKWMVAGNADSPV 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  153 LGRVFIHPESPSTGQYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPADKATEVIQLN----GPDVHTFTF 228
Cdd:cd20199     84 PPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKECGEELSPVKpipsGEGVKAFSF 163

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2024506736  229 PQTEFFAVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20199    164 PETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 195
T-box_TBX22-like cd20200
DNA-binding domain of T-box transcription factor 22 and related T-box proteins; TBX22 is a ...
 75-260 1.46e-62

DNA-binding domain of T-box transcription factor 22 and related T-box proteins; TBX22 is a transcriptional regulator involved in developmental processes. Mutations in the T-Box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome). TBX22 mutation is also associated with cleft lip and palate, and tooth agenesis. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410326  Cd Length: 194  Bit Score: 212.86  E-value: 1.46e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKW--NGRWWEPSGKAEPHV 152
Cdd:cd20200      3 VQVELQGSELWKRFHEIGTEMIITKAGRRMFPSVRVKVKGLDPLKQYYIAMDVVPVDSKRYRYvyHSSQWMVAGNTDHSC 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  153 LG-RVFIHPESPSTGQYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPADKATEVIQ---LNGPDVHTFTF 228
Cdd:cd20200     83 ITpRLYVHPDSPCSGETWMRQIISFDRVKLTNNEMDDKGHIILQSMHKYKPRVHVILQDSRFDLSQiqsLPAEGVKTFSF 162

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2024506736  229 PQTEFFAVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20200    163 PETEFTTVTAYQNQQITKLKIDRNPFAKGFRD 194
T-box_TBX15-like cd20198
DNA-binding domain of T-box transcription factor 15 and related T-box proteins; TBX15 (also ...
 75-260 1.63e-61

DNA-binding domain of T-box transcription factor 15 and related T-box proteins; TBX15 (also known as TBX14) plays an important role in the development of the skeleton of the limb, vertebral column and head, possibly through its control of the number of mesenchymal precursor cells and chondrocytes. TBX15 also plays a role in the differentiation of brown and brite adipocytes. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410324  Cd Length: 198  Bit Score: 209.97  E-value: 1.63e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKW--NGRWWEPSGKAEPHV 152
Cdd:cd20198      7 IQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYvyHSSKWMVAGNADSPV 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  153 LGRVFIHPESPSTGQYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPADKATEVIQLN----GPDVHTFTF 228
Cdd:cd20198     87 PPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKpvptGDGVKTFSF 166

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2024506736  229 PQTEFFAVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20198    167 PETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 198
T-box_TBR1 cd20204
DNA-binding domain of T-box brain protein 1 and related T-box proteins; TBR1 (also known as ...
 77-260 7.86e-58

DNA-binding domain of T-box brain protein 1 and related T-box proteins; TBR1 (also known as T-brain-1 or TES-56) is a neuron-specific transcription factor of the T-box family and involved in forebrain development. It has been recognized as a high-confidence risk gene for autism spectrum disorders (ASD); it regulates the expression of ASD-related genes that are critical for cortical development. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410330  Cd Length: 191  Bit Score: 199.19  E-value: 7.86e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   77 VTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLG-R 155
Cdd:cd20204      4 VYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCGKADTNVQGnR 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  156 VFIHPESPSTGQYWMHQPVSFYKLKLTNN--TLDQEGH-IILHSMHRYLPRLHLVPADK-ATEVIQLNGpDVHTFTFPQT 231
Cdd:cd20204     84 VYMHPDSPNTGAHWMRQEISFGKLKLTNNkgASNNNGQmVVLQSLHKYQPRLHVVEVNEdGTEDTSQPG-RVQTFTFPET 162

                          170       180
                   ....*....|....*....|....*....
gi 2024506736  232 EFFAVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20204    163 QFIAVTAYQNTDITQLKIDHNPFAKGFRD 191
T-box_Fungi_incertae_sedis cd20683
T-box DNA-binding domain; uncharacterized subfamily of fungi classified as Fungi incertae ...
 76-261 1.78e-57

T-box DNA-binding domain; uncharacterized subfamily of fungi classified as Fungi incertae sedis; Fungi incertae sedis refers to a fungal taxonomic group where its broader relationships are unknown or undefined. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors.


Pssm-ID: 410334  Cd Length: 214  Bit Score: 198.77  E-value: 1.78e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   76 TVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKW-NGRwWEPSGK------- 147
Cdd:cd20683      2 QLLLEDADLWAQFHSVQNEMIITKSGRCLFPLLRFRAVNLDPKALYSIALDIEQVSPNRFRFrNGR-WNPIDKdqrgdda 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  148 ------AEPHVLGRVFIHPESPSTGQYWMHQPVSFYKLKLTNNTL------------------DQEGHIILHSMHRYLPR 203
Cdd:cd20683     81 fssgtaDKSVLLPESYIHPDGPQTGAFWMANGISFAKIKLSNRQPnssdrdgpkenitnsisaLPDGHFFLTSFHKYQPR 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2024506736  204 LHLVPADKATEVIQLngpdVHTFTFPQTEFFAVTAYQNIQITQLKIDYNPFAKGFRDD 261
Cdd:cd20683    161 LHLIQHSAGDHDDIL----STTFTFEETEFIAVTHYQNEKVNILKKDYNPHAKGFKDD 214
T-box_TBR2 cd20205
DNA-binding domain of T-box brain protein 2 and related T-box proteins; TBR2 (also known as ...
 77-260 3.87e-56

DNA-binding domain of T-box brain protein 2 and related T-box proteins; TBR2 (also known as Eomesodermin, Eomes, or T-brain-2) is a member of the T-box family of transcription factors and is associated with neurogenesis, cardiogenesis and tumor immune response. This subfamily belongs to the T-box family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410331  Cd Length: 191  Bit Score: 194.13  E-value: 3.87e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   77 VTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLG-R 155
Cdd:cd20205      4 VYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNITGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGnK 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  156 VFIHPESPSTGQYWMHQPVSFYKLKLTNN---TLDQEGHIILHSMHRYLPRLHLVP-ADKATEviQLNGP-DVHTFTFPQ 230
Cdd:cd20205     84 VYVHPESPNTGAHWMRQEISFGKLKLTNNkgaNNNNTQMIVLQSLHKYQPRLHIVEvSEDGVE--DLNDSsKTQTFTFPE 161

                          170       180       190
                   ....*....|....*....|....*....|
gi 2024506736  231 TEFFAVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20205    162 NQFIAVTAYQNTDITQLKIDHNPFAKGFRD 191
T-box_TBXT cd20202
DNA-binding domain of T-box transcription factor T and related T-box proteins; TBXT, also ...
 75-260 4.94e-56

DNA-binding domain of T-box transcription factor T and related T-box proteins; TBXT, also known as Brachyury protein, or protein T, is a transcription factor needed for posterior mesoderm formation and differentiation as well as for the notochord development during embryogenesis. It binds to a 24 base-pair (bp) palindromic site (called the T site) and activates gene transcription when bound to such a site. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. TBXT is the founding member of the T-box family, members of which share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410328  Cd Length: 179  Bit Score: 193.33  E-value: 4.94e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLG 154
Cdd:cd20202      2 LKVSLEESELWLRFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYVNGEWVPGGKPEPQAPS 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  155 RVFIHPESPSTGQYWMHQPVSFYKLKLTNNtLDQEGHIILHSMHRYLPRLHLVpadkateviQLNGPD--VHTFTFPQTE 232
Cdd:cd20202     82 CVYIHPDSPNFGAHWMKAPVSFSKVKLTNK-LNGGGQIMLNSLHKYEPRIHIV---------RVGGPQrmITSHSFPETQ 151

                          170       180
                   ....*....|....*....|....*...
gi 2024506736  233 FFAVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20202    152 FIAVTAYQNEEITALKIKYNPFAKAFLD 179
T-box_TBX19-like cd20201
DNA-binding domain of T-box transcription factor 19 and related T-box proteins; Tbx19 (also ...
 75-260 2.97e-55

DNA-binding domain of T-box transcription factor 19 and related T-box proteins; Tbx19 (also known as Tpit) is a T-box factor restricted to two pituitary (pro-opiomelanocortin) POMC-expressing lineages, the corticotrophs and melanotrophs; it controls terminal differentiation of these lineages. TBX19 activates POMC gene transcription with the cooperation of another transcription factor Pitx1. Mutations of the human TPIT gene cause early onset pituitary adrenocorticotrophic hormone (ACTH) deficiency. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410327  Cd Length: 183  Bit Score: 191.40  E-value: 2.97e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736   75 ITVTLDNNSMWNEFYHRNTEMILTKQGRRMFPYCRYWITGLDASQKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLG 154
Cdd:cd20201      6 LQVSLEDAELWQRFKEVTNEMIVTKNGRRMFPVLKISVSGLDPNAMYSFLLDFAPADGHRWKYVNGEWVPAGKPEPHSHS 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736  155 RVFIHPESPSTGQYWMHQPVSFYKLKLTNNtLDQEGHIILHSMHRYLPRLHLVpadkateviQLNGPD--VHTFTFPQTE 232
Cdd:cd20201     86 CVYIHPDSPNFGAHWMKAPISFSKVKLTNK-LNGGGQIMLNSLHKYEPQIHIV---------RVGGPHrmVTNCSFPETQ 155

                          170       180
                   ....*....|....*....|....*...
gi 2024506736  233 FFAVTAYQNIQITQLKIDYNPFAKGFRD 260
Cdd:cd20201    156 FIAVTAYQNEEITALKIKYNPFAKAFLD 183
bHLHzip_MGA cd18911
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and ...
 2534-2597 5.24e-22

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins; MGA, also termed MAX dimerization protein 5 (MAD5), is a dual specificity T-box/ bHLHzip transcription factor that regulates the expression of both Max-network and T-box family target genes. It contains a Myc-like bHLHZip motif and requires heterodimerization with Max for binding to the preferred Myc-Max-binding site CACGTG. In addition to the bHLHZip domain, MGA harbors a second DNA-binding domain, the T-box or T-domain. It thus binds the preferred Brachyury-binding sequence and represses transcription of reporter genes containing promoter-proximal Brachyury-binding sites.


Pssm-ID: 381481  Cd Length: 65  Bit Score: 91.77  E-value: 5.24e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024506736 2534 RQTHTANERRRRNEMRDLFEKLKRALGLHSLPKVSKCYILKQALDEIQGLTDQADKLTGQKCIL 2597
Cdd:cd18911      1 RRTHTANERRRRNEMRDLFEKLKRTLGLHNLPKVSKYYILKQAFEEIQGLTDQADRLIGQKTLL 64
MGA_dom pfam16059
MGA, conserved domain; This domain can be found in the MAX gene-associated protein (Mga), ...
 1028-1069 2.81e-14

MGA, conserved domain; This domain can be found in the MAX gene-associated protein (Mga), which is a dual-specificity transcription factor that contains both a bHLHZip domain and a T-box domain and is able to bind to and regulate transcriptional targets through both E-box sites as well as T-box-binding elements (TBEs).


Pssm-ID: 464998  Cd Length: 51  Bit Score: 69.44  E-value: 2.81e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2024506736 1028 RRRAPPCNNDFCRLGCICASLA-LEKRQPTHCRRPDCMFGCTC 1069
Cdd:pfam16059    2 KDAKKPCDKDYCQLGCVCDSLAgTRPPKREHCGRADCVLGCVC 44
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1526-1970 1.38e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 1.38e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1526 SSASGTPSVQVPTTSAPKT-TSSISTTSNPSVTTLKALIPPLRQIAARPSPGGVFTKFVMNKVGALQQ-----KIPSVST 1599
Cdd:PHA03247  2608 PRGPAPPSPLPPDTHAPDPpPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQassppQRPRRRA 2687

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1600 CQPLSGPQKFSINPTPIMVVTPVVPSSLSPAhcTVSPGVTTATTTFPVTVESTSVAPSTVSAPSQTRANEPASSPPAiTV 1679
Cdd:PHA03247  2688 ARPTVGSLTSLADPPPPPPTPEPAPHALVSA--TPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT-TA 2764

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1680 TGASATPGINTSTTSSPATPTATVNVTKATVIAAPVPT--LSLPTVVTAPTITCPViTTSPSTVVLTTAVATSVVTTPAS 1757
Cdd:PHA03247  2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWdpADPPAAVLAPAAALPP-AASPAGPLPPPTSAQPTAPPPPP 2843

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1758 SVSSVPIILSGvKSAPSlAPKREDATPQaqalnktPPKISPGAEKRvgPRLLLIPVPQTSPALRPLnnvQLPQKQrmiLQ 1837
Cdd:PHA03247  2844 GPPPPSLPLGG-SVAPG-GDVRRRPPSR-------SPAAKPAAPAR--PPVRRLARPAVSRSTESF---ALPPDQ---PE 2906

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1838 PLRSPGgvnlfrhpngqiiqlVPLQHFRAPGAQPNAQPNVQQPVMFRNPGSVVGIRLPAPAKHPEPPVSSASSVSSSVSS 1917
Cdd:PHA03247  2907 RPPQPQ---------------APPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGR 2971

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024506736 1918 TPPVTNATVQTAGPKSSSVSTPATQASSVSPSVTSYVSQAGtLTLKISPPAAS 1970
Cdd:PHA03247  2972 VAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLA-LHEETDPPPVS 3023
PHA03255 PHA03255
BDLF3; Provisional
 1652-1794 5.36e-10

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 62.61  E-value: 5.36e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1652 TSVAPSTVSAPSQTRANepASSPPAITVTGASATPGINTSTTSSPATPTA-----TVNVTKATVIAAPVPTLSLPTVVTA 1726
Cdd:PHA03255    25 TSSGSSTASAGNVTGTT--AVTTPSPSASGPSTNQSTTLTTTSAPITTTAilstnTTTVTSTGTTVTPVPTTSNASTINV 102

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024506736 1727 PTITCPVITTSPSTVVLTTAVATSVVTTPASSVSSVPI-ILSGVKSAPSLAPKREDATPQAQALNKTPP 1794
Cdd:PHA03255   103 TTKVTAQNITATEAGTGTSTGVTSNVTTRSSSTTSATTrITNATTLAPTLSSKGTSNATKTTAELPTVP 171
bHLHzip_MGA_like cd19682
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) ...
 2548-2594 4.64e-08

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) family; The MGA family includes MGA, Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins. MGA, also termed MAX dimerization protein 5 (MAD5), is a dual specificity T-box/ bHLHzip transcription factor that regulates the expression of both Max-network and T-box family target genes. It contains a Myc-like bHLHZip motif and requires heterodimerization with Max for binding to the preferred Myc-Max-binding site CACGTG. In addition to the bHLHZip domain, MGA harbors a second DNA-binding domain, the T-box or T-domain. It thus binds the preferred Brachyury-binding sequence and represses transcription of reporter genes containing promoter-proximal Brachyury-binding sites. spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.


Pssm-ID: 381525 [Multi-domain]  Cd Length: 65  Bit Score: 52.28  E-value: 4.64e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2024506736 2548 MRDLFEKLKRALGLHSLPKVSKCYILKQALDEIQGLTDQADKLTGQK 2594
Cdd:cd19682     15 LRELFDKLKQLLGLDSDEKASKLAVLTEAIEEIQQLKREEDELQKEK 61
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1598-1787 2.01e-07

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 56.51  E-value: 2.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1598 STCQPLSGPQKFSIN-PTPIMVVTPVVPSSLSPAHCTVSPgvttatttfpvtvesTSVAPSTVSAPSQTRANEPASSPPA 1676
Cdd:pfam17823  129 SLPAAIAALPSEAFSaPRAAACRANASAAPRAAIAAASAP---------------HAASPAPRTAASSTTAASSTTAASS 193

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1677 ITVTGASATPgintsTTSSPATPTATVNVTKATVIAAPVpTLSLPTVVTAP-TITCPVITTSPSTVVLTTAVATSVVTTP 1755
Cdd:pfam17823  194 APTTAASSAP-----ATLTPARGISTAATATGHPAAGTA-LAAVGNSSPAAgTVTAAVGTVTPAALATLAAAAGTVASAA 267

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 2024506736 1756 ASSVSSVPI--ILSGVKSAPSLAPKREDAT---PQAQ 1787
Cdd:pfam17823  268 GTINMGDPHarRLSPAKHMPSDTMARNPAApmgAQAQ 304
PHA03255 PHA03255
BDLF3; Provisional
 1620-1758 4.96e-07

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 53.75  E-value: 4.96e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1620 TPVVPSSLSPAHCTVSPGVTTATTTFPVTVESTSVAPSTVSAPSQTRANEPASSPpAITVTGASATPginTSTTSSPATP 1699
Cdd:PHA03255    25 TSSGSSTASAGNVTGTTAVTTPSPSASGPSTNQSTTLTTTSAPITTTAILSTNTT-TVTSTGTTVTP---VPTTSNASTI 100

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2024506736 1700 TATVNVTKATVIAAPVPTlslptvVTAPTITCPVITTSPSTVVLTTAVATSVVTTPASS 1758
Cdd:PHA03255   101 NVTTKVTAQNITATEAGT------GTSTGVTSNVTTRSSSTTSATTRITNATTLAPTLS 153
PTZ00121 PTZ00121
MAEBL; Provisional
 2194-2646 7.55e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.07  E-value: 7.55e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2194 KDQETAQL--KNHGKEGIHAEWEDKPAKEQEGEVQAHMKENNKVGSRQSQKQQDTQLENKKEQTGTELPQNKKEFQDGPV 2271
Cdd:PTZ00121  1237 KDAEEAKKaeEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKK 1316

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2272 QPEVEKKECKASAEAESLR---EKKTSKSEISSAEEQHNAlgDKQVVSTEEGKTNVAMQEDSKNKEQGAVDSQEEIKTVE 2348
Cdd:PTZ00121  1317 ADEAKKKAEEAKKKADAAKkkaEEAKKAAEAAKAEAEAAA--DEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKAD 1394

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2349 DTVIHANSSWSKISSIAPASENKsetdNKADRSDKSvfmVTEQKAQESRHHKKSSTPNTDTTDYMEEEEEEDDDEDEKTD 2428
Cdd:PTZ00121  1395 EAKKKAEEDKKKADELKKAAAAK----KKADEAKKK---AEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAE 1467

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2429 DS--ADEMLDGASDFSSEEEI-----DVEKVFQDACEYSEDDEQVD-IETVEEL--SEKINIARLKATAANIRPSKEKYH 2498
Cdd:PTZ00121  1468 EAkkADEAKKKAEEAKKADEAkkkaeEAKKKADEAKKAAEAKKKADeAKKAEEAkkADEAKKAEEAKKADEAKKAEEKKK 1547

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2499 A---RNSSDEKLSESPTKQnppvwSRRQKSEEEAFAHYRQTHTANERRRrnemrdlfEKLKRALGLHSLPKVSKCYILKQ 2575
Cdd:PTZ00121  1548 AdelKKAEELKKAEEKKKA-----EEAKKAEEDKNMALRKAEEAKKAEE--------ARIEEVMKLYEEEKKMKAEEAKK 1614

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024506736 2576 ALDEiqglTDQADKLtgqkcilaRKQDTLIRKVSILSGKTEEVV-----LKKLEYMYAKQKAVEAQKKKKNVQSTE 2646
Cdd:PTZ00121  1615 AEEA----KIKAEEL--------KKAEEEKKKVEQLKKKEAEEKkkaeeLKKAEEENKIKAAEEAKKAEEDKKKAE 1678
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1515-1812 9.92e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 51.11  E-value: 9.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1515 STLSTVISKVASSASGTPSVQVPTTSA------PKTTSSISTTSNPSVTTLKALIPPLRQIAARPSPGGVFTKFVMNKVG 1588
Cdd:pfam17823  109 GAASRALAAAASSSPSSAAQSLPAAIAalpseaFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASST 188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1589 ALQQKIP------SVSTCQPLSGpqkfsINPTPIMVVTPvvpsSLSPAHCTVSPGVTTATTTFPVTVESTSVAPSTVSAP 1662
Cdd:pfam17823  189 TAASSAPttaassAPATLTPARG-----ISTAATATGHP----AAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAA 259

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1663 SQTRANEPA----SSPPAITVTGASATPGiNTSTTSSPAT-------PTATVNVTKATVIAAPVPTLSLPTVVTAPTITC 1731
Cdd:pfam17823  260 AGTVASAAGtinmGDPHARRLSPAKHMPS-DTMARNPAAPmgaqaqgPIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPK 338

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1732 PVITTSpSTVVLTTAVATSvvttpASSVSSVPIILSgvksapSLAPKREDATPQAQalnktpPKISPGAEKRVGPRLLLI 1811
Cdd:pfam17823  339 SVASTN-LAVVTTTKAQAK-----EPSASPVPVLHT------SMIPEVEATSPTTQ------PSPLLPTQGAAGPGILLA 400


                   .
gi 2024506736 1812 P 1812
Cdd:pfam17823  401 P 401
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1515-1822 1.27e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 51.07  E-value: 1.27e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1515 STLSTVISKVASSASGTPSVQVPTTSAPKTTSSISTTSN-PSVTTLKALIPPLRQIA--ARPSPGGVFTkfvmnkvgalq 1591
Cdd:pfam05109  415 TTHKVIFSKAPESTTTSPTLNTTGFAAPNTTTGLPSSTHvPTNLTAPASTGPTVSTAdvTSPTPAGTTS----------- 483

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1592 qkipSVSTCQPLSGPQ------KFSINPTPIMVVTPVVPSSLSPAHCTVSPGVTTATTTFPVTVESTSVAPSTVSAPSQT 1665
Cdd:pfam05109  484 ----GASPVTPSPSPRdngtesKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPT 559

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1666 ranepasspPAITVTGASATPGINTSTTSSPATPTATVNVTKATViAAPVPTLSLPTVVTAPTITCPVITTSPSTVvlTT 1745
Cdd:pfam05109  560 ---------PAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTV-GETSPQANTTNHTLGGTSSTPVVTSPPKNA--TS 627

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024506736 1746 AVATSVVTTPASSVSSVPIILSGVksAPSLAPKRED-ATPQAQALNKTPPKISPGAEKRVGPRLLLIPVPQTSPALRP 1822
Cdd:pfam05109  628 AVTTGQHNITSSSTSSMSLRPSSI--SETLSPSTSDnSTSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSSPAPRP 703
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
1618-1760 2.31e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 50.14  E-value: 2.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1618 VVTPVVPSSLSPAHCTVSPGVTTATTTFPVTVESTSVA-PSTVSAPSQTRANEPASSPPAITVTGASATPGINTSTTSSP 1696
Cdd:COG3469     65 AASSTAATSSTTSTTATATAAAAAATSTSATLVATSTAsGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSA 144

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024506736 1697 ATPTATVNVTK---ATVIAAPVPTLSLPTVVTAPTITCPVITTSPSTVVLTTAVATSVVTTPASSVS 1760
Cdd:COG3469    145 GSTTTTTTVSGtetATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPG 211
PHA03255 PHA03255
BDLF3; Provisional
 1690-1807 4.13e-05

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 47.98  E-value: 4.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1690 TSTTSSPATPTatvNVTKATVIAAPVPTLSLPTVVTAPTITcpvITTSPSTVVLTTAVATSVVTTPASSVSSVPIILSGv 1769
Cdd:PHA03255    25 TSSGSSTASAG---NVTGTTAVTTPSPSASGPSTNQSTTLT---TTSAPITTTAILSTNTTTVTSTGTTVTPVPTTSNA- 97

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2024506736 1770 kSAPSLAPKredATPQAQALNKTPPKISPGAEKRVGPR 1807
Cdd:PHA03255    98 -STINVTTK---VTAQNITATEAGTGTSTGVTSNVTTR 131
PTZ00121 PTZ00121
MAEBL; Provisional
 2222-2646 4.51e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.75  E-value: 4.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2222 EGEVQAHMKENNKVGSRQSQKQQD-TQLENKKEQTGTE----LPQNKKEFQDGPVQPEVEKKECKASAEAESLREKKTSK 2296
Cdd:PTZ00121  1057 EGKAEAKAHVGQDEGLKPSYKDFDfDAKEDNRADEATEeafgKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKA 1136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2297 SEISSAEEQHNALGDKQVVST----EEGKTNVAMQ-EDSKNKEQG----AVDSQEEIKTVEDT-VIHANSSWSKISSIAP 2366
Cdd:PTZ00121  1137 EDARKAEEARKAEDAKRVEIArkaeDARKAEEARKaEDAKKAEAArkaeEVRKAEELRKAEDArKAEAARKAEEERKAEE 1216

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2367 A----SENKSETDNKADRSDKSVfmVTEQKAQESRHHKKSSTPNTDTTDYMEEEEEEDDDEDEKTDDS---ADEMLDGAS 2439
Cdd:PTZ00121  1217 ArkaeDAKKAEAVKKAEEAKKDA--EEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADElkkAEEKKKADE 1294

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2440 DFSSEEEIDVEKVFQDACEYSEDDEQVdiETVEELSEKINIARLKATAANIRPSKEKYHARNSSDE-KLSESPTKQnppv 2518
Cdd:PTZ00121  1295 AKKAEEKKKADEAKKKAEEAKKADEAK--KKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEaEAAEEKAEA---- 1368

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2519 wSRRQKSEEEAFAHYRQTHTANERRRRNEMRDLFEKLKRAlglhslPKVSKCYILKQALDEIQGLTDQ---ADKLTgQKC 2595
Cdd:PTZ00121  1369 -AEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKA------DELKKAAAAKKKADEAKKKAEEkkkADEAK-KKA 1440

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2024506736 2596 ILARKQDTLIRKVSilSGKTEEVVLKKLEymyAKQKAVEAQKKKKNVQSTE 2646
Cdd:PTZ00121  1441 EEAKKADEAKKKAE--EAKKAEEAKKKAE---EAKKADEAKKKAEEAKKAD 1486
PTZ00121 PTZ00121
MAEBL; Provisional
 2194-2506 4.82e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.37  E-value: 4.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2194 KDQETAQLKNHGKEGIHAEWEDKPAKEQEGEVQAHMKENNKVGSRQSQKQQDTQLENKKEQTGTELPQNKKEFQDGPVQP 2273
Cdd:PTZ00121  1605 KKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAE 1684

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2274 EVEKKECKASA-EAESLRE----KKTSKSEISSAEEQHNAlGDKQVVSTEEGKTNVamQEDSKNKEQGAVDSQEEIKtve 2348
Cdd:PTZ00121  1685 EDEKKAAEALKkEAEEAKKaeelKKKEAEEKKKAEELKKA-EEENKIKAEEAKKEA--EEDKKKAEEAKKDEEEKKK--- 1758

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2349 dtVIHANSSWSKISSiAPASENKSETDNKADRSDKSVFMVTEQKAQESRHHKKS-STPNTDTTDYMEEEEEEDDDEDEKT 2427
Cdd:PTZ00121  1759 --IAHLKKEEEKKAE-EIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANiIEGGKEGNLVINDSKEMEDSAIKEV 1835

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2428 DDSADEML-------------------DGASDFSSEEEIDVEKVFQDACEYSEDDEQVDIETVEELSEKINIARLKATAA 2488
Cdd:PTZ00121  1836 ADSKNMQLeeadafekhkfnknnengeDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREIPNNNMAGKNNDII 1915

                          330
                   ....*....|....*...
gi 2024506736 2489 NIRPSKEKYHARNSSDEK 2506
Cdd:PTZ00121  1916 DDKLDKDEYIKRDAEETR 1933
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 1664-2064 5.70e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 49.31  E-value: 5.70e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1664 QTRANEPASSPPAITVTGASATPG--------INTSTTSSPATpTATVNVTKATVIAAPVPtlslptvvtaptitcPVIT 1735
Cdd:PRK10263   279 TYTARGVAADPDDVLFSGNRATQPeydeydplLNGAPITEPVA-VAAAATTATQSWAAPVE---------------PVTQ 342

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1736 TSPstvvltTAVATSVVTTPASSVSSVPIILSGvksAPSLAPKREDATPQAQALNKTPPKISPgAEKRVGPRLLLIPVPQ 1815
Cdd:PRK10263   343 TPP------VASVDVPPAQPTVAWQPVPGPQTG---EPVIAPAPEGYPQQSQYAQPAVQYNEP-LQQPVQPQQPYYAPAA 412

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1816 TSPALRPL---NNVQLPQKQRMILQPLRSPGGVNLFRHPNGQIIQLVPLQHFRAPGAQPNAQPNVQQPVMFRNPGSVV-- 1890
Cdd:PRK10263   413 EQPAQQPYyapAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVep 492

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1891 --GIRLPAPAKHP----EPPVSSASSVSSSVSSTPPVTNATVQTAGPKSSSVSTPatqASSVSPSVTSYVSQAgtltlki 1964
Cdd:PRK10263   493 epVVEETKPARPPlyyfEEVEEKRAREREQLAAWYQPIPEPVKEPEPIKSSLKAP---SVAAVPPVEAAAAVS------- 562

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1965 spPAASNVTNQTATESKITGNSGVL--PASNANVVP-LQSGSFALLQLPGQKTVPNSilHHFASLQMKKDSKKIS-QKDD 2040
Cdd:PRK10263   563 --PLASGVKKATLATGAAATVAAPVfsLANSGGPRPqVKEGIGPQLPRPKRIRVPTR--RELASYGIKLPSQRAAeEKAR 638

                          410       420
                   ....*....|....*....|....
gi 2024506736 2041 SGAAQQMETGKNLHSEETEVAQSE 2064
Cdd:PRK10263   639 EAQRNQYDSGDQYNDDEIDAMQQD 662
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
1620-1760 6.89e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 48.60  E-value: 6.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1620 TPVVPSSLSPAHCTVSPGVTTATTTFPVTVESTSVAPSTVSAPSQTRANEPASSPPAITVTGASATPGINTSTTSSPATP 1699
Cdd:COG3469     53 ASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGS 132

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024506736 1700 TATVNV--------TKATVIAAPVPTLSLPTVVTAPTITCPVITTSPSTVVLTTAVATSVVTTPASSVS 1760
Cdd:COG3469    133 TTTSGAsatssagsTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTT 201
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
1651-1784 1.35e-04

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 47.44  E-value: 1.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1651 STSVAPSTVSAPSQTRANEPASSPPAITVTGASATPGINTSTTSSPAT----PTATVNVTKATVIAAPVPTLSLPTVVTA 1726
Cdd:COG3469     76 TSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTsttsSTAGSTTTSGASATSSAGSTTTTTTVSG 155

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2024506736 1727 PTITCPVITTSPSTVVLTTAVATSVVTTPASSVSSVPIILSGVKSAPSLAPKREDATP 1784
Cdd:COG3469    156 TETATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLP 213
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
1603-1744 2.06e-04

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 47.05  E-value: 2.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1603 LSGPQKFSINPTPIMVVTPVVPSSLSPAHCTVSPGVTTATTTFPVTVESTSVAPSTVSAPSQTRANEPAS-SPPAITVTG 1681
Cdd:COG3469     78 TTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTtTTTTVSGTE 157

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024506736 1682 ASATPGINTSTTSSPATPTATVNVTKATVIAAPVPTLSLPTVVTAPTITCPviTTSPSTVVLT 1744
Cdd:COG3469    158 TATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTTGPP--TPGLPKHVLV 218
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 2054-2477 2.99e-04

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 46.55  E-value: 2.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2054 HSEETEVAQSEASVSGGKQEEKEVSVNQPNNVEESVSGTVTPVKNSTALEALEQESKVLQGSGDDGPSLQNDVSTDVISS 2133
Cdd:COG5271    323 EIATADELAAADDEDDDDSAAEDAAEEAATAEDSAAEDTQDAEDEAAGEAADESEGADTDAAADEADAAADDSADDEEAS 402

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2134 DHSYISEKPSDEENEAVTEEKEDSVCSENVGAVSTNSETvcesldhslvAPLNDAHPQSLKDQE-TAQLKNHGKEGIHAE 2212
Cdd:COG5271    403 ADGGTSPTSDTDEEEEEADEDASAGETEDESTDVTSAED----------DIATDEEADSLADEEeEAEAELDTEEDTESA 472

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2213 WEDKPAKEQEGEVQAHMKENNKVGSRQSQKQQDTqlENKKEQTGTELPQNKKEFQDGPVQPEVEKKECKASAEAESLREK 2292
Cdd:COG5271    473 EEDADGDEATDEDDASDDGDEEEAEEDAEAEADS--DELTAEETSADDGADTDAAADPEDSDEDALEDETEGEENAPGSD 550

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2293 KTSKSEISSAEEQHNALGDKQVVSTEEGKTNvamqeDSKNKEQGAVDSQEEIKTVEDTVIHANSswskissiAPASENKS 2372
Cdd:COG5271    551 QDADETDEPEATAEEDEPDEAEAETEDATEN-----ADADETEESADESEEAEASEDEAAEEEE--------ADDDEADA 617

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2373 ETDNKADRSDKSVFMVTEQKAQESRHHKKSSTPNTDTTDYMEEE----EEEDDDEDEKTDDSADEMLDGASDFSSEEEID 2448
Cdd:COG5271    618 DADGAADEEETEEEAAEDEAAEPETDASEAADEDADAETEAEASadesEEEAEDESETSSEDAEEDADAAAAEASDDEEE 697

                          410       420
                   ....*....|....*....|....*....
gi 2024506736 2449 VEKVFQDACEYSEDDEQVDIETVEELSEK 2477
Cdd:COG5271    698 TEEADEDAETASEEADAEEADTEADGTAE 726
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1655-1821 4.02e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.38  E-value: 4.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1655 APSTVSAPSQTRAnEPASSPPAITVTGASATPgintstTSSPATPTATVNVTKATVIAAPVPTLSLPTVVTAPTITCPVI 1734
Cdd:PRK07003   367 APGGGVPARVAGA-VPAPGARAAAAVGASAVP------AVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRG 439

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1735 T---TSPSTVVLTTAVATSVVTTPASSvSSVPIILSGVKSAPSL----APKREDATPQAQALNKTPPKISPGAEKRVGPR 1807
Cdd:PRK07003   440 DdaaDGDAPVPAKANARASADSRCDER-DAQPPADSGSASAPASdappDAAFEPAPRAAAPSAATPAAVPDARAPAAASR 518

                          170
                   ....*....|....
gi 2024506736 1808 LLlIPVPQTSPALR 1821
Cdd:PRK07003   519 ED-APAAAAPPAPE 531
SP4_N cd22536
N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins ...
 1724-1895 6.76e-04

N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Human SP4 is a risk gene of multiple psychiatric disorders including schizophrenia, bipolar disorder, and major depression. SP4 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP4.


Pssm-ID: 411773 [Multi-domain]  Cd Length: 623  Bit Score: 45.29  E-value: 6.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1724 VTAPTITCPVITTSPSTVVLTTAVATSVVTTPASSVSSVPIILSGvkSAPSLAPKREDATPQAQALNKTPPKISPGAEKR 1803
Cdd:cd22536    276 LVSTPITTASVSTMPESPSSSTTCTTTASTSLTSSDTLVSSAETG--QYASTAASSERTEEEPQTSAAESEAQSSSQLQS 353

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1804 VGprllLIPVPQTSPALRPLNNVQLPQKQRMILQplrspggvnlfrHPNGQIIQLVPLQHFRAPGAQP------NAQPNV 1877
Cdd:cd22536    354 NG----LQNVQDQSNSLQQVQIVGQPILQQIQIQ------------QPQQQIIQAIQPQSFQLQSGQTiqtiqqQPLQNV 417

                          170
                   ....*....|....*...
gi 2024506736 1878 qQPVMFRNPGSVVgIRLP 1895
Cdd:cd22536    418 -QLQAVQSPTQVL-IRAP 433
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 1651-1775 9.77e-04

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 44.46  E-value: 9.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1651 STSVAPSTVSAPSQtranEPASSPPAITVTgASATPGINTSTTSSPATPTATVNVTKATVIAAPVPTLSLPTVVTAPTIT 1730
Cdd:COG3266    262 SSASAPATTSLGEQ----QEVSLPPAVAAQ-PAAAAAAQPSAVALPAAPAAAAAAAAPAEAAAPQPTAAKPVVTETAAPA 336

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1731 CPVITTSPSTVVLTTAVATSVVTTPASSVSSVP-----IILSGVKSAPSL 1775
Cdd:COG3266    337 APAPEAAAAAAAPAAPAVAKKLAADEQWLASQPashytLQLLGASSEAAL 386
PTZ00121 PTZ00121
MAEBL; Provisional
 2200-2528 1.16e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 1.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2200 QLKNHGKEGIHAEWEDKPAKEQEG--EVQAHMKENNKVGSRQSQKQQDTQLEN--KKEQTGTELPQNKKEFQDGPVQPEV 2275
Cdd:PTZ00121  1409 ELKKAAAAKKKADEAKKKAEEKKKadEAKKKAEEAKKADEAKKKAEEAKKAEEakKKAEEAKKADEAKKKAEEAKKADEA 1488

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2276 EKKECKASAEAESLREKKTSK---SEISSAEEQHNAlgdKQVVSTEEGKTNVAMQEDSKNKEQGAVDSQEEIKTVEDTvi 2352
Cdd:PTZ00121  1489 KKKAEEAKKKADEAKKAAEAKkkaDEAKKAEEAKKA---DEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEK-- 1563

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2353 hansswSKISSIAPASENKSETDNKAD--------RSDKSVFMVTEQKAQESRHHKKSSTPNTDTTDYMEEEEEEDDDED 2424
Cdd:PTZ00121  1564 ------KKAEEAKKAEEDKNMALRKAEeakkaeeaRIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQ 1637

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2425 EKTDDSadEMLDGASDFSSEEEIDVEKVFQDACEYSEDDEQVDIETVEELSEKINIARLKATAANIRPSKE---KYHARN 2501
Cdd:PTZ00121  1638 LKKKEA--EEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEElkkKEAEEK 1715

                          330       340
                   ....*....|....*....|....*..
gi 2024506736 2502 SSDEKLSESPTKQNPPVWSRRQKSEEE 2528
Cdd:PTZ00121  1716 KKAEELKKAEEENKIKAEEAKKEAEED 1742
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
1602-1804 1.20e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 44.36  E-value: 1.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1602 PLSGPQKFSINPTPIMVVTPVVPSSLSPAHCTVSPGVTTATTTFPVTVESTSVAPSTVSAPSQTRANEPASSPPAITVTG 1681
Cdd:COG3469     11 TAGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAAT 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1682 ASATPGINTSTTSSPATPTATVNVTKATVIAAPVPTLSLPTVVTAPTITCPVITTSPSTVVLTTAVATSVV---TTPASS 1758
Cdd:COG3469     91 STSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGgttTTSTTT 170

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2024506736 1759 VSSVPIILSGVKSAPSLAPKREDATPQAQALNKTPPKISPGAEKRV 1804
Cdd:COG3469    171 TTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLPKHV 216
PRK10856 PRK10856
cytoskeleton protein RodZ;
1650-1762 1.83e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 43.48  E-value: 1.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1650 ESTSVAPSTVSAPSQTRANEPASSPPaitvTGASATPGINTSTTSSPATPTATVNVTKATVIAAPVPTLSLPTVVTAPTI 1729
Cdd:PRK10856   158 SGQSVPLDTSTTTDPATTPAPAAPVD----TTPTNSQTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPAAPATPDG 233

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2024506736 1730 TCPVITtspstvvlttavATSVVTTPASSVSSV 1762
Cdd:PRK10856   234 AAPLPT------------DQAGVSTPAADPNAL 254
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 1652-1789 1.89e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 44.03  E-value: 1.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1652 TSVAPSTVSAPSQTRANEPASSPPAITVTGASATPGINTSTTSSPATPTATVNVTKATVIAAPVPTLSlPTVVTAPTITC 1731
Cdd:PRK14950   358 ALLVPVPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTP-ESAPKLTRAAI 436

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2024506736 1732 PVITTSPSTVVLTTAVATSVVTTPASSVSSVPIILSGVKSApslAPKRedaTPQAQAL 1789
Cdd:PRK14950   437 PVDEKPKYTPPAPPKEEEKALIADGDVLEQLEAIWKQILRD---VPPR---SPAVQAL 488
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1619-1814 2.15e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.68  E-value: 2.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1619 VTPVVPSSLSPAHCTVSPGVTTATTTFPVTVESTSVAPSTVSAPSQTRANEPASSPPAITVTGASATPGINTSTTSSPAT 1698
Cdd:PRK07003   415 AAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAP 494

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1699 PTATVnvtkATVIAAPVPTLSLPTVVTAPTITCPVITTSPStvvltTAVATSVVTTPASSVSSVPIILSGVKSAP-SLAP 1777
Cdd:PRK07003   495 RAAAP----SAATPAAVPDARAPAAASREDAPAAAAPPAPE-----ARPPTPAAAAPAARAGGAAAALDVLRNAGmRVSS 565

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 2024506736 1778 KREDATPQAQAlnktPPKISPGAEKRVGPRlLLIPVP 1814
Cdd:PRK07003   566 DRGARAAAAAK----PAAAPAAAPKPAAPR-VAVQVP 597
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1714-2010 2.40e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 2.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1714 PVPTLSLPTVVTAPTITCPVITtspstvvlttAVATSVVTTPASSVSSVPIILSG---VKSAPSLAPkredatPQAQALN 1790
Cdd:PHA03247  2562 AAPDRSVPPPRPAPRPSEPAVT----------SRARRPDAPPQSARPRAPVDDRGdprGPAPPSPLP------PDTHAPD 2625

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1791 KTPPKISPGAEKRVGPRLLLIPVPQTSPALRPLNNVQLPQKQRMILQPLRSPGgvnlfrhpngqiiqlvPLQHFRAPGAQ 1870
Cdd:PHA03247  2626 PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASS----------------PPQRPRRRAAR 2689

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1871 PnaqpnvqqPVmfrnpGSVVGI-RLPAPAKHPEPPVSSASSvsssvsstppvtnATVQTAGPKSSSVSTPATQASSVSPS 1949
Cdd:PHA03247  2690 P--------TV-----GSLTSLaDPPPPPPTPEPAPHALVS-------------ATPLPPGPAAARQASPALPAAPAPPA 2743

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024506736 1950 VTSYVSQAGTLTLKISPPAASNVTNQTATESKITGnsgvlPASNANVVPLQSGSFALLQLP 2010
Cdd:PHA03247  2744 VPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAG-----PPRRLTRPAVASLSESRESLP 2799
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 2036-2467 2.61e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 43.46  E-value: 2.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2036 SQKDDSGAAQQMETGKNLHSEETEVAQSEASVSGGKQEEKEVSVNQPNNVEESVSGTV--TPVKNSTALEALEQESKVLQ 2113
Cdd:COG5271    395 SADDEEASADGGTSPTSDTDEEEEEADEDASAGETEDESTDVTSAEDDIATDEEADSLadEEEEAEAELDTEEDTESAEE 474

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2114 GSGDDGPSLQNDVSTDVISSDHSYISEKPSDEENEAVTEEKEDSVCSENVGAVSTNS--ETVCESLDHSLVAPLNDAHPQ 2191
Cdd:COG5271    475 DADGDEATDEDDASDDGDEEEAEEDAEAEADSDELTAEETSADDGADTDAAADPEDSdeDALEDETEGEENAPGSDQDAD 554

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2192 SLKDQETAQlKNHGKEGIHAEWEDKPAKEQ--EGEVQAHMKENNKVGSRQSQKQQDTQLENKKEQTGTELPQNKKE---F 2266
Cdd:COG5271    555 ETDEPEATA-EEDEPDEAEAETEDATENADadETEESADESEEAEASEDEAAEEEEADDDEADADADGAADEEETEeeaA 633

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2267 QDGPVQPEVEKKEcKASAEAESLREKKTSKSEISSAEEQHNALGDKQVVSTEEGKTNVAMQEdskNKEQGAVDSQEEIKT 2346
Cdd:COG5271    634 EDEAAEPETDASE-AADEDADAETEAEASADESEEEAEDESETSSEDAEEDADAAAAEASDD---EEETEEADEDAETAS 709

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2347 VEDTvihansswskissiapASENKSETDNKADRSDKSvfmvteqkAQESRHHKKSSTPNTDTTDYMEEEEEEDDDEDE- 2425
Cdd:COG5271    710 EEAD----------------AEEADTEADGTAEEAEEA--------AEEAESADEEAASLPDEADAEEEAEEAEEAEEDd 765

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*...
gi 2024506736 2426 ------KTDDSADEMLDGASDFSSEEEIDVEKVFQDACEYSEDDEQVD 2467
Cdd:COG5271    766 adgleeALEEEKADAEEAATDEEAEAAAEEKEKVADEDQDTDEDALLD 813
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 2024-2517 4.09e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 43.08  E-value: 4.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2024 ASLQMKKDSKKISQKDDSGAAQQMETGKNLHSEETEVAQSEASVSGGKQEEKEVSVNQPNNVEESVSGTVTPVKNSTALE 2103
Cdd:COG5271    146 DLATKDGDELLPSLADNDEAAADEGDELAADGDDTLAVADAIEATPGGTDAVELTATLGATVTTDPGDSVAADDDLAAEE 225

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2104 ALEQESKV--LQGSGDDGPSLQNDVSTDVISSDHS-------YISEKPSDEENEAVTEEKEDSVCSENVGAVSTNSETVC 2174
Cdd:COG5271    226 GASAVVEEedASEDAVAAADETLLADDDDTESAGAtaevggtPDTDDEATDDADGLEAAEDDALDAELTAAQAADPESDD 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2175 ESLDHSLVAPLNDAhpqSLKDQETAQLKNHGKEGIHAEWEDKPAKEQEGEVQAHMKENNKVGsrQSQKQQDTQLENKKEQ 2254
Cdd:COG5271    306 DADDSTLAALEGAA---EDTEIATADELAAADDEDDDDSAAEDAAEEAATAEDSAAEDTQDA--EDEAAGEAADESEGAD 380

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2255 TGTELPQNKKEFQDGPV--------QPEVEKKECKASAEAESLREKKTSKSEISSAEEQHNALG-DKQVVSTEEGKTNVA 2325
Cdd:COG5271    381 TDAAADEADAAADDSADdeeasadgGTSPTSDTDEEEEEADEDASAGETEDESTDVTSAEDDIAtDEEADSLADEEEEAE 460

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2326 MQEDSKNKEQGAV--DSQEEIKTVEDTV-IHANSSWSKISSIAPASENKSETDNKADRSDKsvfmvTEQKAQESRHHKKS 2402
Cdd:COG5271    461 AELDTEEDTESAEedADGDEATDEDDASdDGDEEEAEEDAEAEADSDELTAEETSADDGAD-----TDAAADPEDSDEDA 535

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2403 STPNTDTTDymeeeeeedddEDEKTDDSADEMLDGASDFSSEEEIDVEKVFQDACEYSEDDEQVDIETVEELSEKINIAR 2482
Cdd:COG5271    536 LEDETEGEE-----------NAPGSDQDADETDEPEATAEEDEPDEAEAETEDATENADADETEESADESEEAEASEDEA 604

                          490       500       510
                   ....*....|....*....|....*....|....*
gi 2024506736 2483 LKATAANirPSKEKYHARNSSDEKLSESPTKQNPP 2517
Cdd:COG5271    605 AEEEEAD--DDEADADADGAADEEETEEEAAEDEA 637
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 2214-2475 4.78e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 42.68  E-value: 4.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2214 EDKPAKEQEGEvqahmkeNNKVGSRQSQKQQDTQLENKKEQTGtELPQNKKEFQDGPVQPEVEKKECKASAEAESLREKK 2293
Cdd:TIGR00927  648 EGERPTEAEGE-------NGEESGGEAEQEGETETKGENESEG-EIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEG 719

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2294 TSKSEISSAEEQHNALGDKQVVSTE-----EGKTNVAMQEDSKNKEQGAVDSQEEIKTVEDTVIHANSSWSKISSIAPAS 2368
Cdd:TIGR00927  720 ETEAEGTEDEGEIETGEEGEEVEDEgegeaEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDEGAEG 799

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2369 ENKSETDNKADRSDKSVFMVTEQKAQESRHHKKSSTP-NTDTTDymeeeeeedddeDEKTDDSADEMLDGASDFSSEEEI 2447
Cdd:TIGR00927  800 KVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQElNAENQG------------EAKQDEKGVDGGGGSDGGDSEEEE 867

                          250       260
                   ....*....|....*....|....*...
gi 2024506736 2448 DVEKVFQDACEYSEDDEQVDIETVEELS 2475
Cdd:TIGR00927  868 EEEEEEEEEEEEEEEEEEEEEENEEPLS 895
DUF612 pfam04747
Protein of unknown function, DUF612; This family includes several uncharacterized proteins ...
 2188-2413 5.48e-03

Protein of unknown function, DUF612; This family includes several uncharacterized proteins from Caenorhabditis elegans.


Pssm-ID: 282585 [Multi-domain]  Cd Length: 511  Bit Score: 42.36  E-value: 5.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2188 AHPQSLKDQETAQLKNHGK----EGIHAEWEDKPAKEQEGEVQAHMKENNKVGSRQSQKQQDT---QLENKKEQT----- 2255
Cdd:pfam04747   78 AQKQIAKDHEAEQKVNAKKaaekEARRAEAEAKKRAAQEEEHKQWKAEQERIQKEQEKKEADLkklQAEKKKEKAvkaek 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2256 GTELPQNKKEFQDGPVQPEVEKKEC-----------------KASAEAESLRE---------KKTSKSEISSAEEQHNAL 2309
Cdd:pfam04747  158 AEKAEKTKKASTPAPVEEEIVVKKVandrsaapapepktptnTPAEPAEQVQEitgkknkknKKKSESEATAAPASVEQV 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2310 GDKQVVSTEEGKTNVAMQEdSKNKEQGAVDSQEEIKTVEDTVIHAnsswsKISSIAPASENKSETDNKADRSDKSVFMVT 2389
Cdd:pfam04747  238 VEQPKVVTEEPHQQAAPQE-KKNKKNKRKSESENVPAASETPVEP-----VVETTPPASENQKKNKKDKKKSESEKVVEE 311

                          250       260
                   ....*....|....*....|....
gi 2024506736 2390 EQKAQESRHHKKSSTPNTDTTDYM 2413
Cdd:pfam04747  312 PVQAEAPKSKKPTADDNMDFLDFV 335
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1677-1829 6.05e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.21  E-value: 6.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1677 ITVTGASATPGINTSTTSSPATPTATVNVTKATVIAAPVPTLSL------PTVVTAPTITCPVITT---SPSTVVLTTAV 1747
Cdd:pfam05109  405 ITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFAAPNTTTGLpssthvPTNLTAPASTGPTVSTadvTSPTPAGTTSG 484

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1748 ATSVVTTPA----SSVSSVPIILSGVKSAPSLAPKREDATPQAQalNKTPPKISPGAEKRVGPRLLLIPVPQ-TSPA--- 1819
Cdd:pfam05109  485 ASPVTPSPSprdnGTESKAPDMTSPTSAVTTPTPNATSPTPAVT--TPTPNATSPTLGKTSPTSAVTTPTPNaTSPTpav 562

                          170
                   ....*....|
gi 2024506736 1820 LRPLNNVQLP 1829
Cdd:pfam05109  563 TTPTPNATIP 572
Granin pfam01271
Granin (chromogranin or secretogranin);
2190-2406 6.41e-03

Granin (chromogranin or secretogranin);


Pssm-ID: 279595 [Multi-domain]  Cd Length: 584  Bit Score: 42.33  E-value: 6.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2190 PQSLKDQ-ETAQLKNHGKEGIHAEWEDKPAK---EQEGEVQAHMKENNKVGSrQSQKQQDTQLENKKEqtGTELPQNKKE 2265
Cdd:pfam01271   61 LRDLADQsEASHLSSRSRDGLSDEDMQIITEalrQAENEPGGHSRENQPYAL-QVEKEFKTDHSDDYE--TQQWEEEKLK 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2266 FQDGPVQPEV--EKKECKASAEAESLREKKTSKSEISSAEEQhnalgdkqvVSTEEGKTNvAMQEDSKNKEQGAVDSQEE 2343
Cdd:pfam01271  138 HMRFPLRYEEnsEEKHSEREGELSEVFENPRSQATLKKVFEE---------VSRLDTPSK-QKREKSDEREKSSQESGED 207

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024506736 2344 IKTVEdtvihansSWSKISSIAPASENKSETDNKADRSDksvfmvtEQKAQESRHHKKSSTPN 2406
Cdd:pfam01271  208 TYRQE--------NIPQEDQVGPEDQEPSEEGEEDATQE-------EVKRSRPRTHHGRSLPD 255
rad2 TIGR00600
DNA excision repair protein (rad2); All proteins in this family for which functions are known ...
 2062-2450 6.68e-03

DNA excision repair protein (rad2); All proteins in this family for which functions are known are flap endonucleases that generate the 3' incision next to DNA damage as part of nucleotide excision repair. This family is related to many other flap endonuclease families including the fen1 family. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273166 [Multi-domain]  Cd Length: 1034  Bit Score: 42.19  E-value: 6.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2062 QSEASVSGGKQEEKEVSVNQPNNVEESVSGTVTPVKNSTA-LEALEQ-----ESKVLQGSGDDGPSLQNDVSTDVISSdh 2135
Cdd:TIGR00600  355 AKQAAMSESSSEDSDESEWERQELKRNNVAFVDDGSLSPRtLQAIGQaldddEDKKVSASSDDQASPSKKTKMLLISR-- 432

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2136 syISEKPSDEEneavTEEKEDSVCSENVGAVSTnSETVCESLDHSlvaplndAHPQSLKDQETAQLKNHGKEGIHAEWED 2215
Cdd:TIGR00600  433 --IEVEDDDLD----YLDQGEGIPLMAALQLSS-VNSKPEAVAST-------KIAREVTSSGHEAVPKAVQSLLLGATND 498

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2216 KPakeQEGEVQAHMKENNKVGSRQSQKQQDT-QLENKKEQTG---TELPQNKKEFQDGPVQPEVEKKEC---KASAEAES 2288
Cdd:TIGR00600  499 SP---IPSEFTILDRKSELSIERTVKPVSSEfGLPSQREDKLaipTEGTQNLQGISDHPEQFEFQNELSpleTKNNESNL 575

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2289 LREKKTSKSEISSAEEQHNALGDKQVVSTEEGKTNVAMQEDSKNKEQGAVDSQEEI----------KTVEDTVIHANSSW 2358
Cdd:TIGR00600  576 SSDAETEGSPNPEMPSWSSVTVPSEALDNYETTNPSNAKEVRNFAETGIQTTNVGEsadlllisnpMEVEPMESEKEESE 655

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 2359 SKISSIAPASEnkSETDNKADRSDKSVFMVTEQKAQESRHHKKSSTPNTDTTDYMEEEEEEDDDEDEKTDDSADEMLDGA 2438
Cdd:TIGR00600  656 SDGSFIEVDSV--SSTLELQVPSKSQPTDESEENAENKVASIEGEHRKEIEDLLFDESEEDNIVGMIEEEKDADDFKNEW 733

                          410
                   ....*....|..
gi 2024506736 2439 SDFSSEEEIDVE 2450
Cdd:TIGR00600  734 QDISLEELEALE 745
SP2_N cd22540
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ...
 1744-2049 7.17e-03

N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.


Pssm-ID: 411776 [Multi-domain]  Cd Length: 511  Bit Score: 41.84  E-value: 7.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1744 TTAVATSVVTTPASSVSsvpiilsgvksapslapkrEDATPQAQAL-NKTPPKISPGAekrvgprlllIPVPQTSPA-LR 1821
Cdd:cd22540      3 TAAVSPSEYLQPAASTT-------------------QDSQPSPLALlAATCSKIGPPA----------VEAAVTPPApPQ 53

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1822 PLNNVQLPQKQRMilQPLRSPGGVNLFRHPNGQIIQLvplqhfrAPGAQPNAQPNVQQPVMFRNPGSVVGIRLPAPAKHP 1901
Cdd:cd22540     54 PTPRKLVPIKPAP--LPLGPGKNSIGFLSAKGNIIQL-------QGSQLSSSAPGGQQVFAIQNPTMIIKGSQTRSSTNQ 124

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1902 EPPVSSassvsssvsstppvtnaTVQTAGPKSSSVST---PATQASSVSPSVTSYVSQAGTLTLKISPPAASNVTNQTAT 1978
Cdd:cd22540    125 QYQISP-----------------QIQAAGQINNSGQIqiiPGTNQAIITPVQVLQQPQQAHKPVPIKPAPLQTSNTNSAS 187

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1979 eskitgnsgvlPASNANVVPLQSGSFALLQLPGQKTVPNS---ILHHFASLQMKKdSKKISQKDDSGA------AQQMET 2049
Cdd:cd22540    188 -----------LQVPGNVIKLQSGGNVALTLPVNNLVGTQdgaTQLQLAAAPSKP-SKKIRKKSAQAAqpavtvAEQVET 255
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1493-1752 8.76e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 41.48  E-value: 8.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1493 LHPAGRLAAYVTGRLRPTvldistLSTVISKVASSASGTPSVQVPTTSAPKTTSSISTTSNPSVTTLKALIPPLRQIAAR 1572
Cdd:pfam17823  206 LTPARGISTAATATGHPA------AGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHARR 279

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1573 PSPGgvftkfvmnkvgalqQKIPSVSTCQ---PLSGPQkfsiNPTPIMVVT---PVVPSSLSPahcTVSPGVTTATTTFP 1646
Cdd:pfam17823  280 LSPA---------------KHMPSDTMARnpaAPMGAQ----AQGPIIQVStdqPVHNTAGEP---TPSPSNTTLEPNTP 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1647 VTVESTSvapSTVSAPSQTRANEPASSP---------PAITVTGASATPG--INTSTTSSPATPTATVNV----TKATVI 1711
Cdd:pfam17823  338 KSVASTN---LAVVTTTKAQAKEPSASPvpvlhtsmiPEVEATSPTTQPSplLPTQGAAGPGILLAPEQVateaTAGTAS 414

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 2024506736 1712 AAPVPTlSLPTVVTAPTITCPVITTSPSTVVLTTAVATSVV 1752
Cdd:pfam17823  415 AGPTPR-SSGDPKTLAMASCQLSTQGQYLVVTTDPLTPALV 454
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 1655-1801 9.58e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 41.77  E-value: 9.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024506736 1655 APSTVSAPSQTRANEPASSPPAITVTGASATPGINTSTTSSPATPTATVNVTKATVIAAPVPTLSLPTVVTAPTI-TCPV 1733
Cdd:PRK07994   367 EPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKKSePAAA 446

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024506736 1734 ITTSPSTVVLTTAVATSVVTTPASSVSSVPIILSGVKSAPSLAPKREDATPQA--QALN--KTPPKISPGAE 1801
Cdd:PRK07994   447 SRARPVNSALERLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKAlkKALEheKTPELAAKLAA 518
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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