|
Name |
Accession |
Description |
Interval |
E-value |
| R3H_encore_like |
cd02642 |
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ... |
167-228 |
5.65e-26 |
|
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.
:
Pssm-ID: 100071 Cd Length: 63 Bit Score: 101.53 E-value: 5.65e-26
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024513722 167 DRMMLLKLEQEILDFIGNNEAPRKKFPPMTSYHRMLLHRVAAYFGLEHNVDQSG-KSVIVNKT 228
Cdd:cd02642 1 DRLFVLKLEKDLLAFIKDSTRQSLELPPMNSYYRLLAHRVAQYYGLDHNVDNSGgKCVIVNKT 63
|
|
| SUZ |
pfam12752 |
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched ... |
251-302 |
2.55e-12 |
|
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterized in the C.elegans protein Szy-20 where it has been shown to bind RNA and allow their localization to the centrosome. Warning- the domain has a compositionally biased character.
:
Pssm-ID: 463689 [Multi-domain] Cd Length: 56 Bit Score: 62.72 E-value: 2.55e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 2024513722 251 QKRYILKRDNSSLD--KDDNQMRIRLKDDRRSKSIEEREEEYQRARERIFAQDS 302
Cdd:pfam12752 3 PKMKILRRPSSGSSssSSAGSSGASSSSGSDSKTLEEREAEYAEARARIFGSSE 56
|
|
| PRK10263 super family |
cl35903 |
DNA translocase FtsK; Provisional |
594-849 |
2.55e-07 |
|
DNA translocase FtsK; Provisional
The actual alignment was detected with superfamily member PRK10263:
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 55.09 E-value: 2.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 594 PADPAEPHATMFQSTVVLQPPQqsgyIIAAAPPPPPSGQPVSAP---GYSPSSHPVSQQVlPQQGYMQQPVPQMPACYCT 670
Cdd:PRK10263 336 PVEPVTQTPPVASVDVPPAQPT----VAWQPVPGPQTGEPVIAPapeGYPQQSQYAQPAV-QYNEPLQQPVQPQQPYYAP 410
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 671 PNQYPHSSQQYRPvSVHYNTQQNQPLAQPGQQTGFQVLPNQQQNYqglvgvqqsqnqslvSGQHNNVGNQIQGVIVPYPS 750
Cdd:PRK10263 411 AAEQPAQQPYYAP-APEQPAQQPYYAPAPEQPVAGNAWQAEEQQS---------------TFAPQSTYQTEQTYQQPAAQ 474
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 751 VPSYqvsvpQGSQAVPQQTFQQPVIIPGQSNQGLPttgmPVYY-SVIPSGQQNNLSSSVGYLQP---PGSEQIQFPRTSS 826
Cdd:PRK10263 475 EPLY-----QQPQPVEQQPVVEPEPVVEETKPARP----PLYYfEEVEEKRAREREQLAAWYQPipePVKEPEPIKSSLK 545
|
250 260
....*....|....*....|...
gi 2024513722 827 PCNSQQLQGQQCAAVAAPPGGGV 849
Cdd:PRK10263 546 APSVAAVPPVEAAAAVSPLASGV 568
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
423-759 |
3.46e-06 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 51.48 E-value: 3.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 423 HTQQPLPVPALSQPSHGTPAvyPTVSTSNSLSFDGGINGQVAPTSTSFFLLPLEATGIPPGSILINPQTGQPFLNPDGTP 502
Cdd:PHA03247 2702 PPPPPTPEPAPHALVSATPL--PPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP 2779
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 503 VVYNPPMPQQPVRTQVPGPAQQPPLPPPPQQQPAANHILSQPIRPLQPSSQPVQYSAVSYPPPLLPVSSTQQYSQDNL-G 581
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVApG 2859
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 582 SQFSHMSLARQPPADPAEPHatmfqstvvlQPPQQSgyiiaaapppppsgqpVSAPGYSPSSHPVSQQVLPQQGYMQQPV 661
Cdd:PHA03247 2860 GDVRRRPPSRSPAAKPAAPA----------RPPVRR----------------LARPAVSRSTESFALPPDQPERPPQPQA 2913
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 662 PQMPACYCTPNQYPHSSQQYRPvsvhyntqQNQPLAQPGQQTGFQVLPNQQQnyqglvGVQQSQNQSLVSGQHNNVGNQI 741
Cdd:PHA03247 2914 PPPPQPQPQPPPPPQPQPPPPP--------PPRPQPPLAPTTDPAGAGEPSG------AVPQPWLGALVPGRVAVPRFRV 2979
|
330
....*....|....*...
gi 2024513722 742 QGvivPYPSVPSYQVSVP 759
Cdd:PHA03247 2980 PQ---PAPSREAPASSTP 2994
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| R3H_encore_like |
cd02642 |
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ... |
167-228 |
5.65e-26 |
|
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.
Pssm-ID: 100071 Cd Length: 63 Bit Score: 101.53 E-value: 5.65e-26
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024513722 167 DRMMLLKLEQEILDFIGNNEAPRKKFPPMTSYHRMLLHRVAAYFGLEHNVDQSG-KSVIVNKT 228
Cdd:cd02642 1 DRLFVLKLEKDLLAFIKDSTRQSLELPPMNSYYRLLAHRVAQYYGLDHNVDNSGgKCVIVNKT 63
|
|
| R3H |
smart00393 |
Putative single-stranded nucleic acids-binding domain; |
151-228 |
3.00e-18 |
|
Putative single-stranded nucleic acids-binding domain;
Pssm-ID: 214647 Cd Length: 79 Bit Score: 80.04 E-value: 3.00e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 151 IDLHEFLVNTLKNNPRDRMMLLKLEQEILDFIgNNEAPRKKFPPMTSYHRMLLHRVAAYFGLEHNVDQSG--KSVIVNKT 228
Cdd:smart00393 1 ADFLPVTLDALSYRPRRREELIELELEIARFV-KSTKESVELPPMNSYERKIVHELAEKYGLESESFGEGpkRRVVISKK 79
|
|
| SUZ |
pfam12752 |
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched ... |
251-302 |
2.55e-12 |
|
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterized in the C.elegans protein Szy-20 where it has been shown to bind RNA and allow their localization to the centrosome. Warning- the domain has a compositionally biased character.
Pssm-ID: 463689 [Multi-domain] Cd Length: 56 Bit Score: 62.72 E-value: 2.55e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 2024513722 251 QKRYILKRDNSSLD--KDDNQMRIRLKDDRRSKSIEEREEEYQRARERIFAQDS 302
Cdd:pfam12752 3 PKMKILRRPSSGSSssSSAGSSGASSSSGSDSKTLEEREAEYAEARARIFGSSE 56
|
|
| R3H |
pfam01424 |
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ... |
169-227 |
5.85e-12 |
|
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.
Pssm-ID: 460206 Cd Length: 60 Bit Score: 61.74 E-value: 5.85e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024513722 169 MMLLKLEQEILDFIGNNEAPrKKFPPMTSYHRMLLHRVAAYFGLEHNV--DQSGKSVIVNK 227
Cdd:pfam01424 1 EFLEQLAEKLAEFVKDTGKS-LELPPMSSYERRIIHELAQKYGLESESegEEPNRRVVVYK 60
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
594-849 |
2.55e-07 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 55.09 E-value: 2.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 594 PADPAEPHATMFQSTVVLQPPQqsgyIIAAAPPPPPSGQPVSAP---GYSPSSHPVSQQVlPQQGYMQQPVPQMPACYCT 670
Cdd:PRK10263 336 PVEPVTQTPPVASVDVPPAQPT----VAWQPVPGPQTGEPVIAPapeGYPQQSQYAQPAV-QYNEPLQQPVQPQQPYYAP 410
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 671 PNQYPHSSQQYRPvSVHYNTQQNQPLAQPGQQTGFQVLPNQQQNYqglvgvqqsqnqslvSGQHNNVGNQIQGVIVPYPS 750
Cdd:PRK10263 411 AAEQPAQQPYYAP-APEQPAQQPYYAPAPEQPVAGNAWQAEEQQS---------------TFAPQSTYQTEQTYQQPAAQ 474
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 751 VPSYqvsvpQGSQAVPQQTFQQPVIIPGQSNQGLPttgmPVYY-SVIPSGQQNNLSSSVGYLQP---PGSEQIQFPRTSS 826
Cdd:PRK10263 475 EPLY-----QQPQPVEQQPVVEPEPVVEETKPARP----PLYYfEEVEEKRAREREQLAAWYQPipePVKEPEPIKSSLK 545
|
250 260
....*....|....*....|...
gi 2024513722 827 PCNSQQLQGQQCAAVAAPPGGGV 849
Cdd:PRK10263 546 APSVAAVPPVEAAAAVSPLASGV 568
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
423-759 |
3.46e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 51.48 E-value: 3.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 423 HTQQPLPVPALSQPSHGTPAvyPTVSTSNSLSFDGGINGQVAPTSTSFFLLPLEATGIPPGSILINPQTGQPFLNPDGTP 502
Cdd:PHA03247 2702 PPPPPTPEPAPHALVSATPL--PPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP 2779
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 503 VVYNPPMPQQPVRTQVPGPAQQPPLPPPPQQQPAANHILSQPIRPLQPSSQPVQYSAVSYPPPLLPVSSTQQYSQDNL-G 581
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVApG 2859
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 582 SQFSHMSLARQPPADPAEPHatmfqstvvlQPPQQSgyiiaaapppppsgqpVSAPGYSPSSHPVSQQVLPQQGYMQQPV 661
Cdd:PHA03247 2860 GDVRRRPPSRSPAAKPAAPA----------RPPVRR----------------LARPAVSRSTESFALPPDQPERPPQPQA 2913
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 662 PQMPACYCTPNQYPHSSQQYRPvsvhyntqQNQPLAQPGQQTGFQVLPNQQQnyqglvGVQQSQNQSLVSGQHNNVGNQI 741
Cdd:PHA03247 2914 PPPPQPQPQPPPPPQPQPPPPP--------PPRPQPPLAPTTDPAGAGEPSG------AVPQPWLGALVPGRVAVPRFRV 2979
|
330
....*....|....*...
gi 2024513722 742 QGvivPYPSVPSYQVSVP 759
Cdd:PHA03247 2980 PQ---PAPSREAPASSTP 2994
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
481-742 |
2.34e-05 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 48.49 E-value: 2.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 481 PPGSILINPQTGQPFLNPDGTPVVYNPPMPQQPVRTQVPGPAQqpplppppqqqpaanhilSQPIRPLQPSSQ----PVQ 556
Cdd:pfam09770 107 PAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTGYEKYKE------------------PEPIPDLQVDASlwgvAPK 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 557 YSAvsyPPPLLPVSSTQQYSQDNLGSQFshMSL----------ARQPPADPAEPHATMFQSTVVLQPPQQSGYIIAAAPP 626
Cdd:pfam09770 169 KAA---APAPAPQPAAQPASLPAPSRKM--MSLeeveaamraqAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQ 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 627 PPPSGQPVSAPGYSPSSHPVSQQVLPQQGYMQQPVPQMpacyctPNQYPHSSQQYRPVSVhyntQQNQPLAQPGQQTGFQ 706
Cdd:pfam09770 244 QQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSI------QPQAQQFHQQPPPVPV----QPTQILQNPNRLSAAR 313
|
250 260 270
....*....|....*....|....*....|....*...
gi 2024513722 707 VLPNQQQNY--QGLVGVQQSQNQSLVSGQHNNVGNQIQ 742
Cdd:pfam09770 314 VGYPQNPQPgvQPAPAHQAHRQQGSFGRQAPIITHPQQ 351
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
423-692 |
7.08e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.52 E-value: 7.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 423 HTQQPL---PVPALSQPSHGTPAVyPTVSTSNSLSFDGGINGQVAPTSTsffllPLEATGIPPGSILINPQTGqPFLNPD 499
Cdd:pfam03154 168 QTQPPVlqaQSGAASPPSPPPPGT-TQAATAGPTPSAPSVPPQGSPATS-----QPPNQTQSTAAPHTLIQQT-PTLHPQ 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 500 GTPVVYNP--PMPQQPVRTQVPGPAQQPPLPPPPQQQPAAN-----HILSQPIRPlQPSSQPVQYSAVSYPP---PLLPV 569
Cdd:pfam03154 241 RLPSPHPPlqPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSlqtgpSHMQHPVPP-QPFPLTPQSSQSQVPPgpsPAAPG 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 570 SSTQQYSQDNLGSQFSHMSLARQ---PPADPAEPHATMFQSTVVLQ---------PPQQSG---YIIAAAPPPPPSGQPV 634
Cdd:pfam03154 320 QSQQRIHTPPSQSQLQSQQPPREqplPPAPLSMPHIKPPPTTPIPQlpnpqshkhPPHLSGpspFQMNSNLPPPPALKPL 399
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 635 SA--PGYSPSSHPVSQQVLPQQGYMQQPVPQMPACYCTPNQYPHSSQQYRPVSVHYNTQQ 692
Cdd:pfam03154 400 SSlsTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQ 459
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| R3H_encore_like |
cd02642 |
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ... |
167-228 |
5.65e-26 |
|
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.
Pssm-ID: 100071 Cd Length: 63 Bit Score: 101.53 E-value: 5.65e-26
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024513722 167 DRMMLLKLEQEILDFIGNNEAPRKKFPPMTSYHRMLLHRVAAYFGLEHNVDQSG-KSVIVNKT 228
Cdd:cd02642 1 DRLFVLKLEKDLLAFIKDSTRQSLELPPMNSYYRLLAHRVAQYYGLDHNVDNSGgKCVIVNKT 63
|
|
| R3H |
smart00393 |
Putative single-stranded nucleic acids-binding domain; |
151-228 |
3.00e-18 |
|
Putative single-stranded nucleic acids-binding domain;
Pssm-ID: 214647 Cd Length: 79 Bit Score: 80.04 E-value: 3.00e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 151 IDLHEFLVNTLKNNPRDRMMLLKLEQEILDFIgNNEAPRKKFPPMTSYHRMLLHRVAAYFGLEHNVDQSG--KSVIVNKT 228
Cdd:smart00393 1 ADFLPVTLDALSYRPRRREELIELELEIARFV-KSTKESVELPPMNSYERKIVHELAEKYGLESESFGEGpkRRVVISKK 79
|
|
| SUZ |
pfam12752 |
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched ... |
251-302 |
2.55e-12 |
|
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterized in the C.elegans protein Szy-20 where it has been shown to bind RNA and allow their localization to the centrosome. Warning- the domain has a compositionally biased character.
Pssm-ID: 463689 [Multi-domain] Cd Length: 56 Bit Score: 62.72 E-value: 2.55e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 2024513722 251 QKRYILKRDNSSLD--KDDNQMRIRLKDDRRSKSIEEREEEYQRARERIFAQDS 302
Cdd:pfam12752 3 PKMKILRRPSSGSSssSSAGSSGASSSSGSDSKTLEEREAEYAEARARIFGSSE 56
|
|
| R3H |
pfam01424 |
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ... |
169-227 |
5.85e-12 |
|
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.
Pssm-ID: 460206 Cd Length: 60 Bit Score: 61.74 E-value: 5.85e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024513722 169 MMLLKLEQEILDFIGNNEAPrKKFPPMTSYHRMLLHRVAAYFGLEHNV--DQSGKSVIVNK 227
Cdd:pfam01424 1 EFLEQLAEKLAEFVKDTGKS-LELPPMSSYERRIIHELAQKYGLESESegEEPNRRVVVYK 60
|
|
| R3H |
cd02325 |
R3H domain. The name of the R3H domain comes from the characteristic spacing of the most ... |
171-227 |
1.96e-11 |
|
R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich repeats, ring-type zinc fingers, and KH domains. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.
Pssm-ID: 100064 Cd Length: 59 Bit Score: 60.32 E-value: 1.96e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 2024513722 171 LLKLEQEILDFIGNNEAPRKKFPPMTSYHRMLLHRVAAYFGLEHNVDQSG--KSVIVNK 227
Cdd:cd02325 1 REEREEELEAFAKDAAGKSLELPPMNSYERKLIHDLAEYYGLKSESEGEGpnRRVVITK 59
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
594-849 |
2.55e-07 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 55.09 E-value: 2.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 594 PADPAEPHATMFQSTVVLQPPQqsgyIIAAAPPPPPSGQPVSAP---GYSPSSHPVSQQVlPQQGYMQQPVPQMPACYCT 670
Cdd:PRK10263 336 PVEPVTQTPPVASVDVPPAQPT----VAWQPVPGPQTGEPVIAPapeGYPQQSQYAQPAV-QYNEPLQQPVQPQQPYYAP 410
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 671 PNQYPHSSQQYRPvSVHYNTQQNQPLAQPGQQTGFQVLPNQQQNYqglvgvqqsqnqslvSGQHNNVGNQIQGVIVPYPS 750
Cdd:PRK10263 411 AAEQPAQQPYYAP-APEQPAQQPYYAPAPEQPVAGNAWQAEEQQS---------------TFAPQSTYQTEQTYQQPAAQ 474
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 751 VPSYqvsvpQGSQAVPQQTFQQPVIIPGQSNQGLPttgmPVYY-SVIPSGQQNNLSSSVGYLQP---PGSEQIQFPRTSS 826
Cdd:PRK10263 475 EPLY-----QQPQPVEQQPVVEPEPVVEETKPARP----PLYYfEEVEEKRAREREQLAAWYQPipePVKEPEPIKSSLK 545
|
250 260
....*....|....*....|...
gi 2024513722 827 PCNSQQLQGQQCAAVAAPPGGGV 849
Cdd:PRK10263 546 APSVAAVPPVEAAAAVSPLASGV 568
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
423-759 |
3.46e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 51.48 E-value: 3.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 423 HTQQPLPVPALSQPSHGTPAvyPTVSTSNSLSFDGGINGQVAPTSTSFFLLPLEATGIPPGSILINPQTGQPFLNPDGTP 502
Cdd:PHA03247 2702 PPPPPTPEPAPHALVSATPL--PPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP 2779
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 503 VVYNPPMPQQPVRTQVPGPAQQPPLPPPPQQQPAANHILSQPIRPLQPSSQPVQYSAVSYPPPLLPVSSTQQYSQDNL-G 581
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVApG 2859
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 582 SQFSHMSLARQPPADPAEPHatmfqstvvlQPPQQSgyiiaaapppppsgqpVSAPGYSPSSHPVSQQVLPQQGYMQQPV 661
Cdd:PHA03247 2860 GDVRRRPPSRSPAAKPAAPA----------RPPVRR----------------LARPAVSRSTESFALPPDQPERPPQPQA 2913
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 662 PQMPACYCTPNQYPHSSQQYRPvsvhyntqQNQPLAQPGQQTGFQVLPNQQQnyqglvGVQQSQNQSLVSGQHNNVGNQI 741
Cdd:PHA03247 2914 PPPPQPQPQPPPPPQPQPPPPP--------PPRPQPPLAPTTDPAGAGEPSG------AVPQPWLGALVPGRVAVPRFRV 2979
|
330
....*....|....*...
gi 2024513722 742 QGvivPYPSVPSYQVSVP 759
Cdd:PHA03247 2980 PQ---PAPSREAPASSTP 2994
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
481-742 |
2.34e-05 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 48.49 E-value: 2.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 481 PPGSILINPQTGQPFLNPDGTPVVYNPPMPQQPVRTQVPGPAQqpplppppqqqpaanhilSQPIRPLQPSSQ----PVQ 556
Cdd:pfam09770 107 PAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTGYEKYKE------------------PEPIPDLQVDASlwgvAPK 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 557 YSAvsyPPPLLPVSSTQQYSQDNLGSQFshMSL----------ARQPPADPAEPHATMFQSTVVLQPPQQSGYIIAAAPP 626
Cdd:pfam09770 169 KAA---APAPAPQPAAQPASLPAPSRKM--MSLeeveaamraqAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQ 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 627 PPPSGQPVSAPGYSPSSHPVSQQVLPQQGYMQQPVPQMpacyctPNQYPHSSQQYRPVSVhyntQQNQPLAQPGQQTGFQ 706
Cdd:pfam09770 244 QQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSI------QPQAQQFHQQPPPVPV----QPTQILQNPNRLSAAR 313
|
250 260 270
....*....|....*....|....*....|....*...
gi 2024513722 707 VLPNQQQNY--QGLVGVQQSQNQSLVSGQHNNVGNQIQ 742
Cdd:pfam09770 314 VGYPQNPQPgvQPAPAHQAHRQQGSFGRQAPIITHPQQ 351
|
|
| Med15 |
pfam09606 |
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ... |
579-914 |
7.41e-05 |
|
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.
Pssm-ID: 312941 [Multi-domain] Cd Length: 732 Bit Score: 46.93 E-value: 7.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 579 NLGSQFSHMSLARQPPADPAEPhatmfqstvvlqPPQQSGYIIAAAPPPPPSGQPVSAPGYSPSSHPVSQQVLPQQGymq 658
Cdd:pfam09606 88 NLAGQGTRPQMMGPMGPGPGGP------------MGQQMGGPGTASNLLASLGRPQMPMGGAGFPSQMSRVGRMQPG--- 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 659 qpvPQMPACYCTPNQYPHSSQQYRPVSVHYNTQQNQPLAQPGQQTGFQVLPNQQQNYQGLVGVQQSQNQSLVSGQHNNVG 738
Cdd:pfam09606 153 ---GQAGGMMQPSSGQPGSGTPNQMGPNGGPGQGQAGGMNGGQQGPMGGQMPPQMGVPGMPGPADAGAQMGQQAQANGGM 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 739 NQIQGVIVPYPSVPSYQVSVPQGSQAVPQQTFQQPVIIPgQSNQGLPTTGMPVYYSVIPSGQQNNLSSSVGYLQPPGSEQ 818
Cdd:pfam09606 230 NPQQMGGAPNQVAMQQQQPQQQGQQSQLGMGINQMQQMP-QGVGGGAGQGGPGQPMGPPGQQPGAMPNVMSIGDQNNYQQ 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 819 IQ-FPRTSSPCNSQQLQGQQCAAVAAPPGGGVVMMQ-LNIPNNPQPRNHSPPQW-KQNKYYCDHQRGQKSTELSTLDSAA 895
Cdd:pfam09606 309 QQtRQQQQQQGGNHPAAHQQQMNQSVGQGGQVVALGgLNHLETWNPGNFGGLGAnPMQRGQPGMMSSPSPVPGQQVRQVT 388
|
330
....*....|....*....
gi 2024513722 896 QLQHSPQLGSPVTSPAQSP 914
Cdd:pfam09606 389 PNQFMRQSPQPSVPSPQGP 407
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
632-770 |
1.63e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 42.76 E-value: 1.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 632 QPVSAPGYSPSSHPVsQQVLPQQGYM--QQPVPQmPACYCTPNQYPHSSQQY----RPVSVHYNTQQ-NQPLA-QPGQQT 703
Cdd:PRK10263 742 EPLFTPIVEPVQQPQ-QPVAPQQQYQqpQQPVAP-QPQYQQPQQPVAPQPQYqqpqQPVAPQPQYQQpQQPVApQPQYQQ 819
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024513722 704 GFQVLPNQQQNYQGLVGVQQSQNQSLVSGQHNNVGNQiQGVIVPYPSVPSYQVSVPQGSQAVPQQTF 770
Cdd:PRK10263 820 PQQPVAPQPQYQQPQQPVAPQPQDTLLHPLLMRNGDS-RPLHKPTTPLPSLDLLTPPPSEVEPVDTF 885
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
670-817 |
2.66e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 41.99 E-value: 2.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 670 TPNQYPHSSQQYRPVSVHYNTQQNQPLAQPGQQTGFQVLPNQQQNYQGLVGVQQSQNQSLVSGQHNNVGNQIQGVIVPYP 749
Cdd:PRK10263 746 TPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVA 825
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 750 SVPSYQVSVPQGSQAvPQQTFQQPVIIPGQSNQGL--PTTGMPvyysvipsgqqnnlssSVGYLQPPGSE 817
Cdd:PRK10263 826 PQPQYQQPQQPVAPQ-PQDTLLHPLLMRNGDSRPLhkPTTPLP----------------SLDLLTPPPSE 878
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
489-816 |
6.56e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.52 E-value: 6.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 489 PQTGQPFLNPDGTPVVYNPPMPQQPVRTQVPGPAQQPPLPPPPqqqpaanhiLSQPIRPLQPSSQPVqysavsyPPPLLP 568
Cdd:pfam03154 199 PTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQR---------LPSPHPPLQPMTQPP-------PPSQVS 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 569 VSSTQQYSQDNLGSQFSHmSLARQPP----ADPAEPHATMFQSTVVLQPPQQSGYIiaAAPPPPPSGQPVSAPGYSPSSH 644
Cdd:pfam03154 263 PQPLPQPSLHGQMPPMPH-SLQTGPShmqhPVPPQPFPLTPQSSQSQVPPGPSPAA--PGQSQQRIHTPPSQSQLQSQQP 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 645 PVSQQVLPQQGYMQQ-------PVPQMPacycTPNQYPHSSQQYRPVSVHYNTQQNQPLA------------QPGQQTGF 705
Cdd:pfam03154 340 PREQPLPPAPLSMPHikpppttPIPQLP----NPQSHKHPPHLSGPSPFQMNSNLPPPPAlkplsslsthhpPSAHPPPL 415
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 706 QVLPNQQQNYQGLV---GVQQSQNQSLVSGQHNNVGNQIQGvivpyPSVPSYqvsvpqgsqavPQQTFqqpviIPGQSNQ 782
Cdd:pfam03154 416 QLMPQSQQLPPPPAqppVLTQSQSLPPPAASHPPTSGLHQV-----PSQSPF-----------PQHPF-----VPGGPPP 474
|
330 340 350
....*....|....*....|....*....|....
gi 2024513722 783 GLPttgmpvyysviPSGQQNNLSSSVGYLQPPGS 816
Cdd:pfam03154 475 ITP-----------PSGPPTSTSSAMPGIQPPSS 497
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
423-692 |
7.08e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.52 E-value: 7.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 423 HTQQPL---PVPALSQPSHGTPAVyPTVSTSNSLSFDGGINGQVAPTSTsffllPLEATGIPPGSILINPQTGqPFLNPD 499
Cdd:pfam03154 168 QTQPPVlqaQSGAASPPSPPPPGT-TQAATAGPTPSAPSVPPQGSPATS-----QPPNQTQSTAAPHTLIQQT-PTLHPQ 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 500 GTPVVYNP--PMPQQPVRTQVPGPAQQPPLPPPPQQQPAAN-----HILSQPIRPlQPSSQPVQYSAVSYPP---PLLPV 569
Cdd:pfam03154 241 RLPSPHPPlqPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSlqtgpSHMQHPVPP-QPFPLTPQSSQSQVPPgpsPAAPG 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 570 SSTQQYSQDNLGSQFSHMSLARQ---PPADPAEPHATMFQSTVVLQ---------PPQQSG---YIIAAAPPPPPSGQPV 634
Cdd:pfam03154 320 QSQQRIHTPPSQSQLQSQQPPREqplPPAPLSMPHIKPPPTTPIPQlpnpqshkhPPHLSGpspFQMNSNLPPPPALKPL 399
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024513722 635 SA--PGYSPSSHPVSQQVLPQQGYMQQPVPQMPACYCTPNQYPHSSQQYRPVSVHYNTQQ 692
Cdd:pfam03154 400 SSlsTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQ 459
|
|
| R3H_unknown_2 |
cd06006 |
R3H domain of a group of fungal proteins with unknown function. The name of the R3H domain ... |
173-213 |
9.21e-03 |
|
R3H domain of a group of fungal proteins with unknown function. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.
Pssm-ID: 100076 Cd Length: 59 Bit Score: 35.81 E-value: 9.21e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 2024513722 173 KLEQEILDFIGNNEAPRKKFPPMTSYHRMLLHRVAAYFGLE 213
Cdd:cd06006 3 QIESTLRKFINDKSKRSLRFPPMRSPQRAFIHELAKDYGLY 43
|
|
| |
