|
Name |
Accession |
Description |
Interval |
E-value |
| Beach |
cd06071 |
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in ... |
332-571 |
1.31e-99 |
|
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor (LRBA) and neurobeachin. Disruption of LYST leads to Chediak-Higashi syndrome, characterized by severe immunodeficiency, albinism, poor blood coagulation and neurologic problems. Neurobeachin is a candidate gene linked to autism. LBRA seems to be upregulated in several cancer types. It has been shown that the BEACH domain itself is important for the function of these proteins.
:
Pssm-ID: 100117 [Multi-domain] Cd Length: 275 Bit Score: 321.50 E-value: 1.31e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 332 QWVHGRVSNFDYLMHLNSLAGRRMGDPNYHPVLPWVVDFTT-------KNGKFRDLRKSKFRLNKGDKQLDFTYEMTKQA 404
Cdd:cd06071 3 KWQNGEISNFEYLMYLNTLAGRSFNDLSQYPIFPWVISDYTseeldlnDPSTYRDLSKPIGALNKERLQLLKERYESDSD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 405 FvaggsSGEQLHVPHHISDVLSDITYYVYTARRTP--KSVLCCHVRS-QWEPNEYPASMERMQS--WTPDECIPEFYTDP 479
Cdd:cd06071 83 D-----SDPPFHYGSHYSNPAIVLYYLVRLEPFTTlhLSLQGGHFDAaDRLFNSIPSSWRSASEnpSDVKELIPEFYYLP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 480 SIFRSIHPD---------MPDLDVPSWCSSYEEFIEVHRMLLESREVSQDLHHWIDLTFGYKLQGKDAVKEKNVCLHLVD 550
Cdd:cd06071 158 EFFLNINKFdfgkqdgekVNDVELPPWAKSPEEFIRKHREALESEYVSKNLHHWIDLIFGYKQRGEEAVKAKNVFHPLTY 237
|
250 260 270
....*....|....*....|....*....|....*...
gi 2024465943 551 -----------------NHTHLTTYGVVQLFDQPHPRR 571
Cdd:cd06071 238 egsvdldsidvereaieAQINNFGQTPVQLFTKPHPKR 275
|
|
| WD40 super family |
cl29593 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1621-1921 |
4.38e-26 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
The actual alignment was detected with superfamily member cd00200:
Pssm-ID: 475233 [Multi-domain] Cd Length: 289 Bit Score: 110.50 E-value: 4.38e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1621 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLWplyNYGDGTSEvpprFTYSEHKKSVFYVSQLEASQHVVSC--DGT 1698
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW---DLETGELL----RTLKGHTGPVRDVAASADGTYLASGssDKT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1699 VHIWDQFTGKLIRTFdeLDSKAPITAVTTMPPPyHSISVASADSVLRFIDHRKPGLQHEFRlagGVNAGlIRCLAVSPNG 1778
Cdd:cd00200 75 IRLWDLETGECVRTL--TGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETGKCLTTLR---GHTDW-VNSVAFSPDG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1779 RSVMAGFSSGFIVLLDTRTGLIMRGWPAHEGDILQIKA-AEGNVLISSSSDHSMTVWKELEQKPLHHYKSASEPIH--AF 1855
Cdd:cd00200 148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFsPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAF 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024465943 1856 DLYGNEVVTGTVANKIGVYSMLesSALPVSTtkLSSENfrGTLTSLAVLPMKCHLLLGSDNGVIRL 1921
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLR--TGECVQT--LSGHT--NSVTSLAWSPDGKRLASGSADGTIRI 287
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Beach |
cd06071 |
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in ... |
332-571 |
1.31e-99 |
|
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor (LRBA) and neurobeachin. Disruption of LYST leads to Chediak-Higashi syndrome, characterized by severe immunodeficiency, albinism, poor blood coagulation and neurologic problems. Neurobeachin is a candidate gene linked to autism. LBRA seems to be upregulated in several cancer types. It has been shown that the BEACH domain itself is important for the function of these proteins.
Pssm-ID: 100117 [Multi-domain] Cd Length: 275 Bit Score: 321.50 E-value: 1.31e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 332 QWVHGRVSNFDYLMHLNSLAGRRMGDPNYHPVLPWVVDFTT-------KNGKFRDLRKSKFRLNKGDKQLDFTYEMTKQA 404
Cdd:cd06071 3 KWQNGEISNFEYLMYLNTLAGRSFNDLSQYPIFPWVISDYTseeldlnDPSTYRDLSKPIGALNKERLQLLKERYESDSD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 405 FvaggsSGEQLHVPHHISDVLSDITYYVYTARRTP--KSVLCCHVRS-QWEPNEYPASMERMQS--WTPDECIPEFYTDP 479
Cdd:cd06071 83 D-----SDPPFHYGSHYSNPAIVLYYLVRLEPFTTlhLSLQGGHFDAaDRLFNSIPSSWRSASEnpSDVKELIPEFYYLP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 480 SIFRSIHPD---------MPDLDVPSWCSSYEEFIEVHRMLLESREVSQDLHHWIDLTFGYKLQGKDAVKEKNVCLHLVD 550
Cdd:cd06071 158 EFFLNINKFdfgkqdgekVNDVELPPWAKSPEEFIRKHREALESEYVSKNLHHWIDLIFGYKQRGEEAVKAKNVFHPLTY 237
|
250 260 270
....*....|....*....|....*....|....*...
gi 2024465943 551 -----------------NHTHLTTYGVVQLFDQPHPRR 571
Cdd:cd06071 238 egsvdldsidvereaieAQINNFGQTPVQLFTKPHPKR 275
|
|
| Beach |
smart01026 |
Beige/BEACH domain; The BEACH domain was described in the BEIGE protein (D1035670) and in the ... |
332-571 |
3.45e-83 |
|
Beige/BEACH domain; The BEACH domain was described in the BEIGE protein (D1035670) and in the highly homologous CHS protein. The BEACH domain is usually followed by a series of WD repeats. The function of the BEACH domain is unknown.
Pssm-ID: 214982 Cd Length: 280 Bit Score: 274.87 E-value: 3.45e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 332 QWVHGRVSNFDYLMHLNSLAGRRMGDPNYHPVLPWVV--------DFTTKNGkFRDLRKsKFRLnKGDKQLDFTYEMTKQ 403
Cdd:smart01026 3 KWQNGEISNFEYLMHLNTLAGRSYNDLTQYPVFPWVLadytsetlDLSNPST-FRDLSK-PIGA-LNPERLEFFYERYEE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 404 AfvaggssGEQLHVPHHI-SDVLSDITYYVYTARRTP---------------KSVLCCHVRSQWEPNeYPASMERMQswt 467
Cdd:smart01026 80 L-------EDPDIPPFHYgTHYSSAGIVLYYLIRLEPfttlflqlqggrfdhADRLFHSVAATWRSA-SLESMTDVK--- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 468 pdECIPEFYTDPSIFRSIHP----------DMPDLDVPSWC-SSYEEFIEVHRMLLESREVSQDLHHWIDLTFGYKLQGK 536
Cdd:smart01026 149 --ELIPEFFYLPEFLVNINGfdfgtrqdgeDVDDVELPPWAkGSPEEFIRKHREALESEYVSQHLHHWIDLIFGYKQRGK 226
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 2024465943 537 DAVKEKNVCLHLVD-----------------NHTHLTTYGVV--QLFDQPHPRR 571
Cdd:smart01026 227 EAVEALNVFHPLTYegavdldsiedpverkaLEGQIHNFGQTpkQLFKEPHPPR 280
|
|
| Beach |
pfam02138 |
Beige/BEACH domain; |
332-571 |
1.65e-48 |
|
Beige/BEACH domain;
Pssm-ID: 460459 Cd Length: 277 Bit Score: 174.97 E-value: 1.65e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 332 QWVHGRVSNFDYLMHLNSLAGRRMGDPNYHPVLPWVV-DFTTKN------GKFRDLRKSKFRLNKG-DKQLDFTYEMTkq 403
Cdd:pfam02138 2 KWQNGEISNFEYLMYLNTLAGRSFNDLSQYPVFPWVLaDYTSEEldlndpSTYRDLSKPIGALNEErLEKFKERYEEL-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 404 afvaggssgEQLHVPHHISdvlsdiTYYVytarrTPKSVLCCHVR------SQWE--------PNEYPASMERmqSW--- 466
Cdd:pfam02138 80 ---------EDDDPPFHYG------SHYS-----SPGIVLYYLIRlepfttLHIElqggkfdhPDRLFHSIEE--AWrsa 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 467 ---TPD--ECIPEFYTDPSIFRSIH----------PDMPDLDVPSWC-SSYEEFIEVHRMLLESREVSQDLHHWIDLTFG 530
Cdd:pfam02138 138 snsTSDvkELIPEFFYLPEFLLNSNnfdlggrqdgEKVDDVELPPWAkKSPEEFVRKHREALESDYVSENLHEWIDLIFG 217
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 531 YKLQGKDAVKEKNVCLHL-----VDNH------------THLTTYGVV--QLFDQPHPRR 571
Cdd:pfam02138 218 YKQRGEEAVEALNVFHPLtyegsVDLDsikdpverdaieAQIKNFGQTpkQLFTKPHPPR 277
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1621-1921 |
4.38e-26 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 110.50 E-value: 4.38e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1621 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLWplyNYGDGTSEvpprFTYSEHKKSVFYVSQLEASQHVVSC--DGT 1698
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW---DLETGELL----RTLKGHTGPVRDVAASADGTYLASGssDKT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1699 VHIWDQFTGKLIRTFdeLDSKAPITAVTTMPPPyHSISVASADSVLRFIDHRKPGLQHEFRlagGVNAGlIRCLAVSPNG 1778
Cdd:cd00200 75 IRLWDLETGECVRTL--TGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETGKCLTTLR---GHTDW-VNSVAFSPDG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1779 RSVMAGFSSGFIVLLDTRTGLIMRGWPAHEGDILQIKA-AEGNVLISSSSDHSMTVWKELEQKPLHHYKSASEPIH--AF 1855
Cdd:cd00200 148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFsPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAF 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024465943 1856 DLYGNEVVTGTVANKIGVYSMLesSALPVSTtkLSSENfrGTLTSLAVLPMKCHLLLGSDNGVIRL 1921
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLR--TGECVQT--LSGHT--NSVTSLAWSPDGKRLASGSADGTIRI 287
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1621-1921 |
8.15e-23 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 103.07 E-value: 8.15e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1621 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLWPLynygdgtSEVPPRFTYSEHKKSVFYVSQLEASQHVVSC--DGT 1698
Cdd:COG2319 71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL-------ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGsaDGT 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1699 VHIWDQFTGKLIRTFDEldSKAPITAVtTMPPPYHSISVASADSVLRFIDHRKPGLQHEFRlaggVNAGLIRCLAVSPNG 1778
Cdd:COG2319 144 VRLWDLATGKLLRTLTG--HSGAVTSV-AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT----GHTGAVRSVAFSPDG 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1779 RSVMAGFSSGFIVLLDTRTGLIMRGWPAHEGDILQIK-AAEGNVLISSSSDHSMTVWKELEQKPLHHYKSASEPIH--AF 1855
Cdd:COG2319 217 KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAfSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNsvAF 296
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024465943 1856 DLYGNEVVTGTVANKIGVYSmlessalpVSTTKL--SSENFRGTLTSLAVLPMKCHLLLGSDNGVIRL 1921
Cdd:COG2319 297 SPDGKLLASGSDDGTVRLWD--------LATGKLlrTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1621-1655 |
2.17e-07 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 48.88 E-value: 2.17e-07
10 20 30
....*....|....*....|....*....|....*
gi 2024465943 1621 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLW 1655
Cdd:pfam00400 4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1621-1655 |
1.03e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 46.92 E-value: 1.03e-06
10 20 30
....*....|....*....|....*....|....*
gi 2024465943 1621 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLW 1655
Cdd:smart00320 5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Beach |
cd06071 |
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in ... |
332-571 |
1.31e-99 |
|
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor (LRBA) and neurobeachin. Disruption of LYST leads to Chediak-Higashi syndrome, characterized by severe immunodeficiency, albinism, poor blood coagulation and neurologic problems. Neurobeachin is a candidate gene linked to autism. LBRA seems to be upregulated in several cancer types. It has been shown that the BEACH domain itself is important for the function of these proteins.
Pssm-ID: 100117 [Multi-domain] Cd Length: 275 Bit Score: 321.50 E-value: 1.31e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 332 QWVHGRVSNFDYLMHLNSLAGRRMGDPNYHPVLPWVVDFTT-------KNGKFRDLRKSKFRLNKGDKQLDFTYEMTKQA 404
Cdd:cd06071 3 KWQNGEISNFEYLMYLNTLAGRSFNDLSQYPIFPWVISDYTseeldlnDPSTYRDLSKPIGALNKERLQLLKERYESDSD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 405 FvaggsSGEQLHVPHHISDVLSDITYYVYTARRTP--KSVLCCHVRS-QWEPNEYPASMERMQS--WTPDECIPEFYTDP 479
Cdd:cd06071 83 D-----SDPPFHYGSHYSNPAIVLYYLVRLEPFTTlhLSLQGGHFDAaDRLFNSIPSSWRSASEnpSDVKELIPEFYYLP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 480 SIFRSIHPD---------MPDLDVPSWCSSYEEFIEVHRMLLESREVSQDLHHWIDLTFGYKLQGKDAVKEKNVCLHLVD 550
Cdd:cd06071 158 EFFLNINKFdfgkqdgekVNDVELPPWAKSPEEFIRKHREALESEYVSKNLHHWIDLIFGYKQRGEEAVKAKNVFHPLTY 237
|
250 260 270
....*....|....*....|....*....|....*...
gi 2024465943 551 -----------------NHTHLTTYGVVQLFDQPHPRR 571
Cdd:cd06071 238 egsvdldsidvereaieAQINNFGQTPVQLFTKPHPKR 275
|
|
| Beach |
smart01026 |
Beige/BEACH domain; The BEACH domain was described in the BEIGE protein (D1035670) and in the ... |
332-571 |
3.45e-83 |
|
Beige/BEACH domain; The BEACH domain was described in the BEIGE protein (D1035670) and in the highly homologous CHS protein. The BEACH domain is usually followed by a series of WD repeats. The function of the BEACH domain is unknown.
Pssm-ID: 214982 Cd Length: 280 Bit Score: 274.87 E-value: 3.45e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 332 QWVHGRVSNFDYLMHLNSLAGRRMGDPNYHPVLPWVV--------DFTTKNGkFRDLRKsKFRLnKGDKQLDFTYEMTKQ 403
Cdd:smart01026 3 KWQNGEISNFEYLMHLNTLAGRSYNDLTQYPVFPWVLadytsetlDLSNPST-FRDLSK-PIGA-LNPERLEFFYERYEE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 404 AfvaggssGEQLHVPHHI-SDVLSDITYYVYTARRTP---------------KSVLCCHVRSQWEPNeYPASMERMQswt 467
Cdd:smart01026 80 L-------EDPDIPPFHYgTHYSSAGIVLYYLIRLEPfttlflqlqggrfdhADRLFHSVAATWRSA-SLESMTDVK--- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 468 pdECIPEFYTDPSIFRSIHP----------DMPDLDVPSWC-SSYEEFIEVHRMLLESREVSQDLHHWIDLTFGYKLQGK 536
Cdd:smart01026 149 --ELIPEFFYLPEFLVNINGfdfgtrqdgeDVDDVELPPWAkGSPEEFIRKHREALESEYVSQHLHHWIDLIFGYKQRGK 226
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 2024465943 537 DAVKEKNVCLHLVD-----------------NHTHLTTYGVV--QLFDQPHPRR 571
Cdd:smart01026 227 EAVEALNVFHPLTYegavdldsiedpverkaLEGQIHNFGQTpkQLFKEPHPPR 280
|
|
| Beach |
pfam02138 |
Beige/BEACH domain; |
332-571 |
1.65e-48 |
|
Beige/BEACH domain;
Pssm-ID: 460459 Cd Length: 277 Bit Score: 174.97 E-value: 1.65e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 332 QWVHGRVSNFDYLMHLNSLAGRRMGDPNYHPVLPWVV-DFTTKN------GKFRDLRKSKFRLNKG-DKQLDFTYEMTkq 403
Cdd:pfam02138 2 KWQNGEISNFEYLMYLNTLAGRSFNDLSQYPVFPWVLaDYTSEEldlndpSTYRDLSKPIGALNEErLEKFKERYEEL-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 404 afvaggssgEQLHVPHHISdvlsdiTYYVytarrTPKSVLCCHVR------SQWE--------PNEYPASMERmqSW--- 466
Cdd:pfam02138 80 ---------EDDDPPFHYG------SHYS-----SPGIVLYYLIRlepfttLHIElqggkfdhPDRLFHSIEE--AWrsa 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 467 ---TPD--ECIPEFYTDPSIFRSIH----------PDMPDLDVPSWC-SSYEEFIEVHRMLLESREVSQDLHHWIDLTFG 530
Cdd:pfam02138 138 snsTSDvkELIPEFFYLPEFLLNSNnfdlggrqdgEKVDDVELPPWAkKSPEEFVRKHREALESDYVSENLHEWIDLIFG 217
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 531 YKLQGKDAVKEKNVCLHL-----VDNH------------THLTTYGVV--QLFDQPHPRR 571
Cdd:pfam02138 218 YKQRGEEAVEALNVFHPLtyegsVDLDsikdpverdaieAQIKNFGQTpkQLFTKPHPPR 277
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1621-1921 |
4.38e-26 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 110.50 E-value: 4.38e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1621 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLWplyNYGDGTSEvpprFTYSEHKKSVFYVSQLEASQHVVSC--DGT 1698
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW---DLETGELL----RTLKGHTGPVRDVAASADGTYLASGssDKT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1699 VHIWDQFTGKLIRTFdeLDSKAPITAVTTMPPPyHSISVASADSVLRFIDHRKPGLQHEFRlagGVNAGlIRCLAVSPNG 1778
Cdd:cd00200 75 IRLWDLETGECVRTL--TGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETGKCLTTLR---GHTDW-VNSVAFSPDG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1779 RSVMAGFSSGFIVLLDTRTGLIMRGWPAHEGDILQIKA-AEGNVLISSSSDHSMTVWKELEQKPLHHYKSASEPIH--AF 1855
Cdd:cd00200 148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFsPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAF 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024465943 1856 DLYGNEVVTGTVANKIGVYSMLesSALPVSTtkLSSENfrGTLTSLAVLPMKCHLLLGSDNGVIRL 1921
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLR--TGECVQT--LSGHT--NSVTSLAWSPDGKRLASGSADGTIRI 287
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1617-1875 |
9.89e-26 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 109.35 E-value: 9.89e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1617 HQIKLQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLWPLynygdGTSEVppRFTYSEHKKSVFYVSQLEASQHVVSC- 1695
Cdd:cd00200 40 TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL-----ETGEC--VRTLTGHTSYVSSVAFSPDGRILSSSs 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1696 -DGTVHIWDQFTGKLIRTFDelDSKAPITAVtTMPPPYHSISVASADSVLRFIDHRKPGLQHEFRLaggvNAGLIRCLAV 1774
Cdd:cd00200 113 rDKTIKVWDVETGKCLTTLR--GHTDWVNSV-AFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTG----HTGEVNSVAF 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1775 SPNGRSVMAGFSSGFIVLLDTRTGLIMRGWPAHEGDILQIKAAEGNVLISSSS-DHSMTVWKELEQKPLHHYKSASEPIH 1853
Cdd:cd00200 186 SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSeDGTIRVWDLRTGECVQTLSGHTNSVT 265
|
250 260
....*....|....*....|....
gi 2024465943 1854 --AFDLYGNEVVTGTVANKIGVYS 1875
Cdd:cd00200 266 slAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1621-1921 |
8.15e-23 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 103.07 E-value: 8.15e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1621 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLWPLynygdgtSEVPPRFTYSEHKKSVFYVSQLEASQHVVSC--DGT 1698
Cdd:COG2319 71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL-------ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGsaDGT 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1699 VHIWDQFTGKLIRTFDEldSKAPITAVtTMPPPYHSISVASADSVLRFIDHRKPGLQHEFRlaggVNAGLIRCLAVSPNG 1778
Cdd:COG2319 144 VRLWDLATGKLLRTLTG--HSGAVTSV-AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT----GHTGAVRSVAFSPDG 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1779 RSVMAGFSSGFIVLLDTRTGLIMRGWPAHEGDILQIK-AAEGNVLISSSSDHSMTVWKELEQKPLHHYKSASEPIH--AF 1855
Cdd:COG2319 217 KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAfSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNsvAF 296
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024465943 1856 DLYGNEVVTGTVANKIGVYSmlessalpVSTTKL--SSENFRGTLTSLAVLPMKCHLLLGSDNGVIRL 1921
Cdd:COG2319 297 SPDGKLLASGSDDGTVRLWD--------LATGKLlrTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1621-1865 |
2.25e-21 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 98.83 E-value: 2.25e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1621 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLWplyNYGDGTsevpPRFTYSEHKKSVFYVsqleA----SQHVVSC- 1695
Cdd:COG2319 155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW---DLATGK----LLRTLTGHTGAVRSV----AfspdGKLLASGs 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1696 -DGTVHIWDQFTGKLIRTFDelDSKAPITAVTtMPPPYHSISVASADSVLRFIDhRKPGlQHEFRLAGGVNAglIRCLAV 1774
Cdd:COG2319 224 aDGTVRLWDLATGKLLRTLT--GHSGSVRSVA-FSPDGRLLASGSADGTVRLWD-LATG-ELLRTLTGHSGG--VNSVAF 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1775 SPNGRSVMAGFSSGFIVLLDTRTGLIMRGWPAHEGDILQIK-AAEGNVLISSSSDHSMTVWKELEQKPLHHYKSASEPIH 1853
Cdd:COG2319 297 SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAfSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT 376
|
250
....*....|....
gi 2024465943 1854 --AFDLYGNEVVTG 1865
Cdd:COG2319 377 svAFSPDGRTLASG 390
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1621-1834 |
1.08e-20 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 96.90 E-value: 1.08e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1621 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLWPLynygdgtSEVPPRFTYSEHKKSVFYVSQLEASQHVVSC--DGT 1698
Cdd:COG2319 197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL-------ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGsaDGT 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1699 VHIWDQFTGKLIRTFDelDSKAPITAVttmpppyhSIS-------VASADSVLRFIDHRKPGLQHEFRlaggVNAGLIRC 1771
Cdd:COG2319 270 VRLWDLATGELLRTLT--GHSGGVNSV--------AFSpdgkllaSGSDDGTVRLWDLATGKLLRTLT----GHTGAVRS 335
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024465943 1772 LAVSPNGRSVMAGFSSGFIVLLDTRTGLIMRGWPAHEGDILQIK-AAEGNVLISSSSDHSMTVW 1834
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAfSPDGRTLASGSADGTVRLW 399
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1621-1797 |
2.25e-11 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 68.01 E-value: 2.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1621 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLWplyNYGDGTsevpPRFTYSEHKKSVFYVSQLEASQHVVSC--DGT 1698
Cdd:COG2319 239 LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW---DLATGE----LLRTLTGHSGGVNSVAFSPDGKLLASGsdDGT 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1699 VHIWDQFTGKLIRTFDelDSKAPITAVTTMPPPyHSISVASADSVLRFIDHRKPGLQHEFRlaggVNAGLIRCLAVSPNG 1778
Cdd:COG2319 312 VRLWDLATGKLLRTLT--GHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDLATGELLRTLT----GHTGAVTSVAFSPDG 384
|
170
....*....|....*....
gi 2024465943 1779 RSVMAGFSSGFIVLLDTRT 1797
Cdd:COG2319 385 RTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1696-1921 |
8.82e-10 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 63.01 E-value: 8.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1696 DGTVHIWDQFTGKLIRTFdeLDSKAPITAVTTMPPPYHSISvASADSVLRFIDHRKPGLQHEFRLAGGVnaglIRCLAVS 1775
Cdd:COG2319 57 DLTLLLLDAAAGALLATL--LGHTAAVLSVAFSPDGRLLAS-ASADGTVRLWDLATGLLLRTLTGHTGA----VRSVAFS 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024465943 1776 PNGRSVMAGFSSGFIVLLDTRTGLIMRGWPAHEGDILQIK-AAEGNVLISSSSDHSMTVWKELEQKPLHHYKSASEPIH- 1853
Cdd:COG2319 130 PDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAfSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRs 209
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024465943 1854 -AFDLYGNEVVTGTVANKIGVYSMleSSALPVSTTKLSSenfrGTLTSLAVLPMKCHLLLGSDNGVIRL 1921
Cdd:COG2319 210 vAFSPDGKLLASGSADGTVRLWDL--ATGKLLRTLTGHS----GSVRSVAFSPDGRLLASGSADGTVRL 272
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1621-1655 |
2.17e-07 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 48.88 E-value: 2.17e-07
10 20 30
....*....|....*....|....*....|....*
gi 2024465943 1621 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLW 1655
Cdd:pfam00400 4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1621-1655 |
1.03e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 46.92 E-value: 1.03e-06
10 20 30
....*....|....*....|....*....|....*
gi 2024465943 1621 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLW 1655
Cdd:smart00320 5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| ANAPC4_WD40 |
pfam12894 |
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ... |
1735-1811 |
4.70e-04 |
|
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,
Pssm-ID: 403945 [Multi-domain] Cd Length: 91 Bit Score: 41.11 E-value: 4.70e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024465943 1735 ISVASADSVLRFidHRKPGlQHEFRLAGGVNAGLIRCLAVSPNGRSVMAGFSSGFIVLLDTRTGLIMRGWPAHEGDI 1811
Cdd:pfam12894 10 IALATEDGELLL--HRLNW-QRVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLI 83
|
|
| |
