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Conserved domains on  [gi|2024407468|ref|XP_040556156|]
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kelch-like protein 8 isoform X1 [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-168 1.32e-74

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 234.88  E-value: 1.32e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  49 DFHSSLLHFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLT 128
Cdd:cd18238     1 DSFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2024407468 129 LTVDNVQPLLYAACILQVELVAKACCEYMKLHFHPSNCLA 168
Cdd:cd18238    81 LTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 160-256 4.41e-63

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


:

Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 203.69  E-value: 4.41e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 160 HFHPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANP 239
Cdd:cd18448     1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                          90
                  ....*....|....*..
gi 2024407468 240 QHHATWLDEILAQVRLP 256
Cdd:cd18448    81 QHRKRHLDDLLSQVRLP 97
PHA03098 super family cl33709
kelch-like protein; Provisional
 57-565 1.21e-61

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 214.25  E-value: 1.21e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  57 FFEAGELCDVTLKVGT--KLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIeirdFDGDAIEDLVKFVYSSRLTLTVDNV 134
Cdd:PHA03098    3 SFELQKFCDESIIIVNggGIIKVHKIILSSSSEYFKKMFKNNFKENEINLN----IDYDSFNEVIKYIYTGKINITSNNV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 135 QPLLYAACILQVELVAKACCEYMKLHFHPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLL 214
Cdd:PHA03098   79 KDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKIL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 215 SSSDLNIENEKQVYNAAIKWLLANPQHHATWLDEILAQVRLPLLPI-------CFLMGVVAKEEIVKQNLKCR------- 280
Cdd:PHA03098  159 SDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEegikklkRWKLRIKKKKIVFNKRCIKIiyskkyn 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 281 -------------DLLDEARNYHLHLSSRAVPDFEYSIRT---TPRKQTAG------VLFCVGGRGGSGDPFRSIECYSI 338
Cdd:PHA03098  239 lnkilprsstfgsIIYIHITMSIFTYNYITNYSPLSEINTiidIHYVYCFGsvvlnnVIYFIGGMNKNNLSVNSVVSYDT 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 339 NKNSWFFGPEMNSRRRHVGVISVGGRVYAVGGHDGNEHLGSMEVFDPLTNKWMIKASMNTKRRGIALASLGGPIYAIGGL 418
Cdd:PHA03098  319 KTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGI 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 419 DDN-TCFSDVERYDIESDRWSAVAPMNTPRGGVGSVAlmvslfpcrsgpgsrpafqissksskqsfpvqlFQNHVYAVGG 497
Cdd:PHA03098  399 SKNdELLKTVECFSLNTNKWSKGSPLPISHYGGCAIY---------------------------------HDGKIYVIGG 445

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024407468 498 ---NDGIASLSSVEKYDPHLDKWMEVKEMGQRRAGNGVSELHGCLYVVGGFDDNSPLSSVERFDPRSDKWE 565
Cdd:PHA03098  446 isyIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516
Kelch smart00612
Kelch domain;
585-629 2.08e-11

Kelch domain;


:

Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 59.11  E-value: 2.08e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2024407468  585 RIFAVGGHNGNAYLNTVEAFDPIVNRWELVGSVSHCRAGAGVAVC 629
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
 
Name Accession Description Interval E-value
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-168 1.32e-74

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 234.88  E-value: 1.32e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  49 DFHSSLLHFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLT 128
Cdd:cd18238     1 DSFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2024407468 129 LTVDNVQPLLYAACILQVELVAKACCEYMKLHFHPSNCLA 168
Cdd:cd18238    81 LTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 160-256 4.41e-63

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 203.69  E-value: 4.41e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 160 HFHPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANP 239
Cdd:cd18448     1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                          90
                  ....*....|....*..
gi 2024407468 240 QHHATWLDEILAQVRLP 256
Cdd:cd18448    81 QHRKRHLDDLLSQVRLP 97
PHA03098 PHA03098
kelch-like protein; Provisional
 57-565 1.21e-61

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 214.25  E-value: 1.21e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  57 FFEAGELCDVTLKVGT--KLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIeirdFDGDAIEDLVKFVYSSRLTLTVDNV 134
Cdd:PHA03098    3 SFELQKFCDESIIIVNggGIIKVHKIILSSSSEYFKKMFKNNFKENEINLN----IDYDSFNEVIKYIYTGKINITSNNV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 135 QPLLYAACILQVELVAKACCEYMKLHFHPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLL 214
Cdd:PHA03098   79 KDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKIL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 215 SSSDLNIENEKQVYNAAIKWLLANPQHHATWLDEILAQVRLPLLPI-------CFLMGVVAKEEIVKQNLKCR------- 280
Cdd:PHA03098  159 SDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEegikklkRWKLRIKKKKIVFNKRCIKIiyskkyn 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 281 -------------DLLDEARNYHLHLSSRAVPDFEYSIRT---TPRKQTAG------VLFCVGGRGGSGDPFRSIECYSI 338
Cdd:PHA03098  239 lnkilprsstfgsIIYIHITMSIFTYNYITNYSPLSEINTiidIHYVYCFGsvvlnnVIYFIGGMNKNNLSVNSVVSYDT 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 339 NKNSWFFGPEMNSRRRHVGVISVGGRVYAVGGHDGNEHLGSMEVFDPLTNKWMIKASMNTKRRGIALASLGGPIYAIGGL 418
Cdd:PHA03098  319 KTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGI 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 419 DDN-TCFSDVERYDIESDRWSAVAPMNTPRGGVGSVAlmvslfpcrsgpgsrpafqissksskqsfpvqlFQNHVYAVGG 497
Cdd:PHA03098  399 SKNdELLKTVECFSLNTNKWSKGSPLPISHYGGCAIY---------------------------------HDGKIYVIGG 445

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024407468 498 ---NDGIASLSSVEKYDPHLDKWMEVKEMGQRRAGNGVSELHGCLYVVGGFDDNSPLSSVERFDPRSDKWE 565
Cdd:PHA03098  446 isyIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
342-628 1.26e-48

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 171.49  E-value: 1.26e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 342 SWFFGPEMNSRRRHVGVISVGGRVYAVGGHDGNEHLGSMEVFDPLTNKWMIKASMNTKRR-GIALASLGGPIYAIGGLDD 420
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRhHAAAVAQDGKLYVFGGFTG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 421 N----TCFSDVERYDIESDRWSAVAPMNTPRGGVGSVALmvslfpcrsgpgsrpafqissksskqsfpvqlfQNHVYAVG 496
Cdd:COG3055    82 AnpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLL---------------------------------DGKIYVVG 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 497 GNDGIASLSSVEKYDPHLDKWMEVKEMGQRRAG-NGVSELHGCLYVVGGFDDNSPlssverfdprSDKWEYVAELTTPRG 575
Cdd:COG3055   129 GWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHlAAAVLPDGKILVIGGRNGSGF----------SNTWTTLAPLPTARA 198

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2024407468 576 GVGIATLMGRIFAVGGHNGnaYLNTVEAFDPIVNRWELVGSVSHCRAGAGVAV 628
Cdd:COG3055   199 GHAAAVLGGKILVFGGESG--FSDEVEAYDPATNTWTALGELPTPRHGHAAVL 249
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 166-268 5.40e-35

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 127.66  E-value: 5.40e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 166 CLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHATW 245
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 2024407468 246 LDEILAQVRLPLLPICFLMGVVA 268
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 166-266 1.15e-29

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 112.82  E-value: 1.15e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  166 CLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHATW 245
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 2024407468  246 LDEILAQVRLPLLPICFLMGV 266
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 54-158 7.02e-28

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 107.73  E-value: 7.02e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  54 LLHFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLtLTVDN 133
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*
gi 2024407468 134 VQPLLYAACILQVELVAKACCEYMK 158
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLI 104
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 65-158 1.27e-23

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 95.45  E-value: 1.27e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468   65 DVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACIL 144
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....
gi 2024407468  145 QVELVAKACCEYMK 158
Cdd:smart00225  81 QIPGLVELCEEFLL 94
Kelch smart00612
Kelch domain;
538-584 7.93e-14

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 66.04  E-value: 7.93e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2024407468  538 CLYVVGGFDDNSPLSSVERFDPRSDKWEYVAELTTPRGGVGIATLMG 584
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 352-397 1.60e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 62.24  E-value: 1.60e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2024407468 352 RRRHVGVISVGGRVYAVGGHDGNEHLGSMEVFDPLTNKWMIKASMN 397
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
585-629 2.08e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 59.11  E-value: 2.08e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2024407468  585 RIFAVGGHNGNAYLNTVEAFDPIVNRWELVGSVSHCRAGAGVAVC 629
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 573-616 7.26e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 51.84  E-value: 7.26e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2024407468 573 PRGGVGIATLMGRIFAVGGHNGNAYLNTVEAFDPIVNRWELVGS 616
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPS 44
 
Name Accession Description Interval E-value
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-168 1.32e-74

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 234.88  E-value: 1.32e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  49 DFHSSLLHFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLT 128
Cdd:cd18238     1 DSFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2024407468 129 LTVDNVQPLLYAACILQVELVAKACCEYMKLHFHPSNCLA 168
Cdd:cd18238    81 LTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 160-256 4.41e-63

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 203.69  E-value: 4.41e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 160 HFHPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANP 239
Cdd:cd18448     1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                          90
                  ....*....|....*..
gi 2024407468 240 QHHATWLDEILAQVRLP 256
Cdd:cd18448    81 QHRKRHLDDLLSQVRLP 97
PHA03098 PHA03098
kelch-like protein; Provisional
 57-565 1.21e-61

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 214.25  E-value: 1.21e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  57 FFEAGELCDVTLKVGT--KLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIeirdFDGDAIEDLVKFVYSSRLTLTVDNV 134
Cdd:PHA03098    3 SFELQKFCDESIIIVNggGIIKVHKIILSSSSEYFKKMFKNNFKENEINLN----IDYDSFNEVIKYIYTGKINITSNNV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 135 QPLLYAACILQVELVAKACCEYMKLHFHPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLL 214
Cdd:PHA03098   79 KDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKIL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 215 SSSDLNIENEKQVYNAAIKWLLANPQHHATWLDEILAQVRLPLLPI-------CFLMGVVAKEEIVKQNLKCR------- 280
Cdd:PHA03098  159 SDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEegikklkRWKLRIKKKKIVFNKRCIKIiyskkyn 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 281 -------------DLLDEARNYHLHLSSRAVPDFEYSIRT---TPRKQTAG------VLFCVGGRGGSGDPFRSIECYSI 338
Cdd:PHA03098  239 lnkilprsstfgsIIYIHITMSIFTYNYITNYSPLSEINTiidIHYVYCFGsvvlnnVIYFIGGMNKNNLSVNSVVSYDT 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 339 NKNSWFFGPEMNSRRRHVGVISVGGRVYAVGGHDGNEHLGSMEVFDPLTNKWMIKASMNTKRRGIALASLGGPIYAIGGL 418
Cdd:PHA03098  319 KTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGI 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 419 DDN-TCFSDVERYDIESDRWSAVAPMNTPRGGVGSVAlmvslfpcrsgpgsrpafqissksskqsfpvqlFQNHVYAVGG 497
Cdd:PHA03098  399 SKNdELLKTVECFSLNTNKWSKGSPLPISHYGGCAIY---------------------------------HDGKIYVIGG 445

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024407468 498 ---NDGIASLSSVEKYDPHLDKWMEVKEMGQRRAGNGVSELHGCLYVVGGFDDNSPLSSVERFDPRSDKWE 565
Cdd:PHA03098  446 isyIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
342-628 1.26e-48

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 171.49  E-value: 1.26e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 342 SWFFGPEMNSRRRHVGVISVGGRVYAVGGHDGNEHLGSMEVFDPLTNKWMIKASMNTKRR-GIALASLGGPIYAIGGLDD 420
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRhHAAAVAQDGKLYVFGGFTG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 421 N----TCFSDVERYDIESDRWSAVAPMNTPRGGVGSVALmvslfpcrsgpgsrpafqissksskqsfpvqlfQNHVYAVG 496
Cdd:COG3055    82 AnpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLL---------------------------------DGKIYVVG 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 497 GNDGIASLSSVEKYDPHLDKWMEVKEMGQRRAG-NGVSELHGCLYVVGGFDDNSPlssverfdprSDKWEYVAELTTPRG 575
Cdd:COG3055   129 GWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHlAAAVLPDGKILVIGGRNGSGF----------SNTWTTLAPLPTARA 198

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2024407468 576 GVGIATLMGRIFAVGGHNGnaYLNTVEAFDPIVNRWELVGSVSHCRAGAGVAV 628
Cdd:COG3055   199 GHAAAVLGGKILVFGGESG--FSDEVEAYDPATNTWTALGELPTPRHGHAAVL 249
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
308-595 4.51e-48

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 169.95  E-value: 4.51e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 308 TPRKQTAGVLfcVGGR----GG--SGDPFRSIECYSINKNSWFFGPEMNSRRR-HVGVISVGGRVYAVGGHDGN----EH 376
Cdd:COG3055    11 TPRSEAAAAL--LDGKvyvaGGlsGGSASNSFEVYDPATNTWSELAPLPGPPRhHAAAVAQDGKLYVFGGFTGAnpssTP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 377 LGSMEVFDPLTNKWMIKASMNTKRRGIALASLGGPIYAIGGLDDNTCFSDVERYDIESDRWSAVAPMNTPRGGVGSVAlm 456
Cdd:COG3055    89 LNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAV-- 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 457 vslfpcrsgpgsrpafqissksskqsfpvqLFQNHVYAVGGNDGiaslssvekyDPHLDKWMEVKEMGQRRAGNGVSELH 536
Cdd:COG3055   167 ------------------------------LPDGKILVIGGRNG----------SGFSNTWTTLAPLPTARAGHAAAVLG 206

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2024407468 537 GCLYVVGGfdDNSPLSSVERFDPRSDKWEYVAELTTPRGGVGIATLMGRIFAVGGHNGN 595
Cdd:COG3055   207 GKILVFGG--ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKP 263
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-158 2.11e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 129.32  E-value: 2.11e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  49 DFHSSLLHFFEA----GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYS 124
Cdd:cd18247     1 DLPSSGFPVMEEirrqGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYS 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2024407468 125 SRLTLTVDNVQPLLYAACILQVELVAKACCEYMK 158
Cdd:cd18247    81 GRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLK 114
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 166-268 5.40e-35

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 127.66  E-value: 5.40e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 166 CLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHATW 245
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 2024407468 246 LDEILAQVRLPLLPICFLMGVVA 268
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 62-167 2.02e-34

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 127.18  E-value: 2.02e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  62 ELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAA 141
Cdd:cd18249    22 ELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAA 101

                          90       100
                  ....*....|....*....|....*.
gi 2024407468 142 CILQVELVAKACCEYMKLHFHPSNCL 167
Cdd:cd18249   102 CLLQLAEIQEVCCEFLKRQLDPSNCL 127
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 163-291 3.21e-34

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 126.74  E-value: 3.21e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 163 PSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 242
Cdd:cd18452     3 PSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKEER 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2024407468 243 ATWLDEILAQVRLPLLPICFLMGVVAKEEIVKQNLKCRDLLDEARNYHL 291
Cdd:cd18452    83 EDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHL 131
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-167 7.00e-34

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 124.79  E-value: 7.00e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  63 LCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAAC 142
Cdd:cd18234     1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATAC 80

                          90       100
                  ....*....|....*....|....*
gi 2024407468 143 ILQVELVAKACCEYMKLHFHPSNCL 167
Cdd:cd18234    81 LLQLSEVVEACCGFLMKQLHPSNCL 105
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 162-274 9.58e-34

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 124.65  E-value: 9.58e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 162 HPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQH 241
Cdd:cd18445     2 HPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPEN 81

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2024407468 242 HATWLDEILAQVRLPLLPICFLMGVVAKEEIVK 274
Cdd:cd18445    82 RKEHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
307-558 7.36e-33

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 127.58  E-value: 7.36e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 307 TTPRKQTA-----GVLFCVGGRGG---SGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVGGRVYAVGGHDGNEHLG 378
Cdd:COG3055    58 GPPRHHAAavaqdGKLYVFGGFTGanpSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVA 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 379 SMEVFDPLTNKWMIKASMNTKRRGIALASL-GGPIYAIGGLDDNTcfsdverydiESDRWSAVAPMNTPRGGVGSVALmv 457
Cdd:COG3055   138 WVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGKILVIGGRNGSG----------FSNTWTTLAPLPTARAGHAAAVL-- 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 458 slfpcrsgpgsrpafqissksskqsfpvqlfQNHVYAVGGNDGIasLSSVEKYDPHLDKWMEVKEMGQRRAGNGVSELHG 537
Cdd:COG3055   206 -------------------------------GGKILVFGGESGF--SDEVEAYDPATNTWTALGELPTPRHGHAAVLTDG 252

                         250       260
                  ....*....|....*....|....*
gi 2024407468 538 CLYVVGGFDDN----SPLSSVERFD 558
Cdd:COG3055   253 KVYVIGGETKPgvrtPLVTSAEVYD 277
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 162-264 5.04e-31

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 116.66  E-value: 5.04e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 162 HPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQH 241
Cdd:cd18444     3 HPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLPE 82

                          90       100
                  ....*....|....*....|...
gi 2024407468 242 HATWLDEILAQVRLPLLPICFLM 264
Cdd:cd18444    83 RKKHLAKLLALIRLPLLTPQFLA 105
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 62-167 8.02e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 116.73  E-value: 8.02e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  62 ELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAA 141
Cdd:cd18256    19 EFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELLVAA 98

                          90       100
                  ....*....|....*....|....*.
gi 2024407468 142 CILQVELVAKACCEYMKLHFHPSNCL 167
Cdd:cd18256    99 DMLQLTEVVEICCEFLKGQLHPSNCI 124
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-167 8.27e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 116.82  E-value: 8.27e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYA 140
Cdd:cd18237    19 KTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARISVNSNNVQSLLDA 98

                          90       100
                  ....*....|....*....|....*..
gi 2024407468 141 ACILQVELVAKACCEYMKLHFHPSNCL 167
Cdd:cd18237    99 ANQYQIEPVKKMCVDFLKEQLDASNCL 125
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-163 1.68e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 115.99  E-value: 1.68e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  63 LCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAAC 142
Cdd:cd18235    21 LCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTAEIQVTEENVQVLLPAAN 100

                          90       100
                  ....*....|....*....|.
gi 2024407468 143 ILQVELVAKACCEYMKLHFHP 163
Cdd:cd18235   101 LLQLTDVRDACCDFLQSQLHP 121
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 161-290 1.92e-30

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 115.93  E-value: 1.92e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 161 FHPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQ 240
Cdd:cd18513     1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2024407468 241 HHATWLDEILAQVRLPLLPICFLMGVVAKEEIVKQNLKCRDLLDEARNYH 290
Cdd:cd18513    81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-166 3.61e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 114.85  E-value: 3.61e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  48 KDFHSSLLHFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRL 127
Cdd:cd18242     6 KSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTETV 85

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2024407468 128 TLTVDNVQPLLYAACILQVELVAKACCEYMKLHFHPSNC 166
Cdd:cd18242    86 HVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 166-266 1.15e-29

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 112.82  E-value: 1.15e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  166 CLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHATW 245
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 2024407468  246 LDEILAQVRLPLLPICFLMGV 266
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 161-290 7.43e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 111.66  E-value: 7.43e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 161 FHPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQ 240
Cdd:cd18512     1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2024407468 241 HHATWLDEILAQVRLPLLPICFLMGVVAKEEIVKQNLKCRDLLDEARNYH 290
Cdd:cd18512    81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-144 1.80e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 108.80  E-value: 1.80e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  63 LCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAAC 142
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80


                  ..
gi 2024407468 143 IL 144
Cdd:cd18186    81 KL 82
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 54-158 7.02e-28

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 107.73  E-value: 7.02e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  54 LLHFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLtLTVDN 133
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*
gi 2024407468 134 VQPLLYAACILQVELVAKACCEYMK 158
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLI 104
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-170 1.97e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 107.44  E-value: 1.97e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  56 HFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQ 135
Cdd:cd18336    12 NYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYTGVLELKEDTIE 91

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2024407468 136 PLLYAACILQVELVAKACCEYMKLHFHPSNCLAVR 170
Cdd:cd18336    92 SLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGIR 126
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-170 3.50e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 103.97  E-value: 3.50e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  57 FFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQP 136
Cdd:cd18335    13 YLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIEN 92

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2024407468 137 LLYAACILQVELVAKACCEYMKLHFHPSNCLAVR 170
Cdd:cd18335    93 LLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGIR 126
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-163 4.02e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 103.39  E-value: 4.02e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYA 140
Cdd:cd18257    16 HELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQATVESLLPA 95

                          90       100
                  ....*....|....*....|...
gi 2024407468 141 ACILQVELVAKACCEYMKLHFHP 163
Cdd:cd18257    96 ANLLQIKLVLKECCDFLESQLDP 118
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-170 1.79e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 102.06  E-value: 1.79e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  43 ANEAWKDFHSSLLHffeaGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFV 122
Cdd:cd18337     7 AEQTFKKMENYLRH----KQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQYA 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2024407468 123 YSSRLTLTVDNVQPLLYAACILQVELVAKACCEYMKLHFHPSNCLAVR 170
Cdd:cd18337    83 YTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIR 130
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 161-259 1.81e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 101.25  E-value: 1.81e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 161 FHPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQ 240
Cdd:cd18509     2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                          90
                  ....*....|....*....
gi 2024407468 241 HHATWLDEILAQVRLPLLP 259
Cdd:cd18509    82 RRCSDLSMLLAYIRLPLLP 100
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-163 1.91e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 101.69  E-value: 1.91e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  63 LCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAAC 142
Cdd:cd18338    21 LCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEENVQVLLPAAG 100

                          90       100
                  ....*....|....*....|.
gi 2024407468 143 ILQVELVAKACCEYMKLHFHP 163
Cdd:cd18338   101 LLQLQDVKKTCCEFLESQLHP 121
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-163 3.44e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 100.95  E-value: 3.44e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  63 LCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAAC 142
Cdd:cd18339    21 LCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAAS 100

                          90       100
                  ....*....|....*....|.
gi 2024407468 143 ILQVELVAKACCEYMKLHFHP 163
Cdd:cd18339   101 LLQLMDVRQNCCDFLQSQLHP 121
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-169 1.04e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 100.28  E-value: 1.04e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  57 FFEAGELCDVTLKVGT--------KLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLT 128
Cdd:cd18273    20 FYDARLLTDVTIEVNGpgsgpgsgRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMALIIDYCYTGRVT 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2024407468 129 LTVDNVQPLLYAACILQVELVAKACCEYMKLHFHPSNCLAV 169
Cdd:cd18273   100 LSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGI 140
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-166 2.49e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 98.24  E-value: 2.49e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  54 LLHFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDN 133
Cdd:cd18255     9 LNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSELTLDLDC 88

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2024407468 134 VQPLLYAACILQVELVAKACCEYMKLHFHPSNC 166
Cdd:cd18255    89 IQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-166 2.92e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 98.30  E-value: 2.92e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  65 DVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACIL 144
Cdd:cd18250    23 DVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTGRVTVTQDNVEALLRAADLF 102

                          90       100
                  ....*....|....*....|..
gi 2024407468 145 QVELVAKACCEYMKLHFHPSNC 166
Cdd:cd18250   103 QFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-169 4.19e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 98.25  E-value: 4.19e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  50 FHSSLLH-----FFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYS 124
Cdd:cd18269     9 YQQTLLQdglkdLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYT 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2024407468 125 SRLTLTVDNVQPLLYAACILQVELVAKACCEYMKLHFHPSNCLAV 169
Cdd:cd18269    89 SEIDLNDQNVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-163 5.54e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 98.18  E-value: 5.54e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  51 HSSLLHFFEA----------GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVK 120
Cdd:cd18246    17 HNSKRHYHDAfvsmnrmrqrGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQ 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2024407468 121 FVYSSRLTLTVDNVQPLLYAACILQVELVAKACCEYMKLHFHP 163
Cdd:cd18246    97 YAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDP 139
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 160-263 7.46e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 96.67  E-value: 7.46e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 160 HFHPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANP 239
Cdd:cd18511     1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                          90       100
                  ....*....|....*....|....
gi 2024407468 240 QHHATWLDEILAQVRLPLLPICFL 263
Cdd:cd18511    81 EQRRKDLSKLLAYIRLPLLAPQFL 104
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 65-158 1.27e-23

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 95.45  E-value: 1.27e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468   65 DVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACIL 144
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....
gi 2024407468  145 QVELVAKACCEYMK 158
Cdd:smart00225  81 QIPGLVELCEEFLL 94
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-169 1.40e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 96.39  E-value: 1.40e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  48 KDFHSSLLH----FFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVY 123
Cdd:cd18268     4 QDLSSELLRqlnsLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVY 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2024407468 124 SSRLTLTVDNVQPLLYAACILQVELVAKACCEYMKLHFHPSNCLAV 169
Cdd:cd18268    84 TGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-157 4.34e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 94.75  E-value: 4.34e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  59 EAGELCDVTLKVG----TKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNV 134
Cdd:cd18248    17 LSQQLCDVTLKVKyqdpKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIEFAYTASISVGEKCV 96

                          90       100
                  ....*....|....*....|...
gi 2024407468 135 QPLLYAACILQVELVAKACCEYM 157
Cdd:cd18248    97 LHVLPGAVMYQMDSVVKACCDFL 119
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 60-169 6.24e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 94.25  E-value: 6.24e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  60 AGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLY 139
Cdd:cd18306    15 NRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVYS 94

                          90       100       110
                  ....*....|....*....|....*....|
gi 2024407468 140 AACILQVELVAKACCEYMKLHFHPSNCLAV 169
Cdd:cd18306    95 AAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 160-259 7.98e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 93.44  E-value: 7.98e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 160 HFHPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANP 239
Cdd:cd18510     1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                          90       100
                  ....*....|....*....|
gi 2024407468 240 QHHATWLDEILAQVRLPLLP 259
Cdd:cd18510    81 QNRQKDLGMLLSYIRLPLLP 100
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 58-169 9.34e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 94.28  E-value: 9.34e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  58 FEAGELCDVTLKVGT-KLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQP 136
Cdd:cd18274    17 YDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYTSRVTLTEANVQA 96

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2024407468 137 LLYAACILQVELVAKACCEYMKLHFHPSNCLAV 169
Cdd:cd18274    97 LFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-169 2.30e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 92.99  E-value: 2.30e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  42 EANEAWKDFHSSLLH-----FFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIE 116
Cdd:cd18341     1 EIKEELRLYQSTLLQdglkeLLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2024407468 117 DLVKFVYSSRLTLTVDNVQPLLYAACILQVELVAKACCEYMKLHFHPSNCLAV 169
Cdd:cd18341    81 MILKYLYSAEIDLNDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-166 3.07e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 92.21  E-value: 3.07e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  56 HFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQ 135
Cdd:cd18253    11 EFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKVKITTENVQ 90

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2024407468 136 PLLYAACILQVELVAKACCEYMKLHFHPSNC 166
Cdd:cd18253    91 YLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 161-267 4.94e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 91.21  E-value: 4.94e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 161 FHPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQ 240
Cdd:cd18457     1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                          90       100
                  ....*....|....*....|....*..
gi 2024407468 241 HHATWLDEILAQVRLPLLPICFLMGVV 267
Cdd:cd18457    81 NREEYLPELLSKVRLPLLRPQFLTDRV 107
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-167 6.60e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 91.99  E-value: 6.60e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  49 DFHSSLLH----FFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYS 124
Cdd:cd18270     8 EYAVSLLEqlkfFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYT 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2024407468 125 SRLTLTVDNVQPLLYAACILQVELVAKACCEYMKLHFHPSNCL 167
Cdd:cd18270    88 GNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-169 7.47e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 91.82  E-value: 7.47e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  54 LLHFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDN 133
Cdd:cd18340    18 LKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQN 97

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2024407468 134 VQPLLYAACILQVELVAKACCEYMKLHFHPSNCLAV 169
Cdd:cd18340    98 VQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAI 133
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 163-258 9.18e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 90.18  E-value: 9.18e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 163 PSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 242
Cdd:cd18459     4 PSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIQER 83

                          90
                  ....*....|....*.
gi 2024407468 243 ATWLDEILAQVRLPLL 258
Cdd:cd18459    84 RPHLPQVLQHVRLPLL 99
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-167 1.22e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 91.04  E-value: 1.22e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  49 DFHSSLLHFFEAGELCDVTLKVGTKLI-SCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRL 127
Cdd:cd18252     7 DFLDAFRTFYLDGLFTDITLQCASGQIfHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQI 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2024407468 128 TLTVDNVQPLLYAACILQVELVAKACCEYMKLHFHPSNCL 167
Cdd:cd18252    87 CITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCL 126
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 62-167 2.99e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 90.27  E-value: 2.99e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  62 ELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAA 141
Cdd:cd18259    31 KLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYTGKLTINQGNVEALIRTS 110

                          90       100
                  ....*....|....*....|....*.
gi 2024407468 142 CILQVELVAKACCEYMKLHFHPSNCL 167
Cdd:cd18259   111 NRLQFPTVRKVCSRYLQQQIDATNCL 136
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-166 3.05e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 89.31  E-value: 3.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYA 140
Cdd:cd18240    15 GKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPITAENVEELLPA 94

                          90       100
                  ....*....|....*....|....*.
gi 2024407468 141 ACILQVELVAKACCEYMKLHFHPSNC 166
Cdd:cd18240    95 ADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-169 7.53e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 88.71  E-value: 7.53e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  59 EAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLL 138
Cdd:cd18276    17 ELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSSDLHLTNSNVQGVA 96

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2024407468 139 YAACILQVELVAKACCEYMKLHFHPSNCLAV 169
Cdd:cd18276    97 TAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 162-263 1.34e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 87.08  E-value: 1.34e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 162 HPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQH 241
Cdd:cd18468     1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                          90       100
                  ....*....|....*....|..
gi 2024407468 242 HATWLDEILAQVRLPLLPICFL 263
Cdd:cd18468    81 RKQHIAELLAVVRLPFIHPSYL 102
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 163-259 1.68e-20

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 86.76  E-value: 1.68e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 163 PSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 242
Cdd:cd18466     3 PANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKR 82

                          90
                  ....*....|....*..
gi 2024407468 243 ATWLDEILAQVRLPLLP 259
Cdd:cd18466    83 KKHVVEVLEPVRFPLLP 99
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-166 5.92e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 86.06  E-value: 5.92e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  63 LCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAAC 142
Cdd:cd18236    24 LTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLITKQNVQRVLEAAS 103

                          90       100
                  ....*....|....*....|....
gi 2024407468 143 ILQVELVAKACCEYMKLHFHPSNC 166
Cdd:cd18236   104 LFQFLRMVDACASFLTEALHPENC 127
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 163-250 5.04e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 81.96  E-value: 5.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 163 PSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 242
Cdd:cd18458     4 PSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDEENR 83


                  ....*...
gi 2024407468 243 ATWLDEIL 250
Cdd:cd18458    84 RQYLEALL 91
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-157 6.24e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 82.94  E-value: 6.24e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  52 SSLLHFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTV 131
Cdd:cd18251    12 DGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYTSELELSL 91

                          90       100
                  ....*....|....*....|....*.
gi 2024407468 132 DNVQPLLYAACILQVELVAKACCEYM 157
Cdd:cd18251    92 DNVQETLTAACQLQIPEVIGFCCDFL 117
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 164-235 6.27e-19

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 81.30  E-value: 6.27e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024407468 164 SNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWL 235
Cdd:cd18508     3 TNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWL 74
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-167 3.60e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 81.21  E-value: 3.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  65 DVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRD-FDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACI 143
Cdd:cd18254    24 DVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDsLHPEVLELLLDFAYSSRIIINEENAESLLEAGDM 103

                          90       100
                  ....*....|....*....|....
gi 2024407468 144 LQVELVAKACCEYMKLHFHPSNCL 167
Cdd:cd18254   104 LQFHDVRDAAAEFLEKNLYPSNCL 127
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 60-168 3.71e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 80.97  E-value: 3.71e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  60 AGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLY 139
Cdd:cd18265    20 SGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLE 99

                          90       100
                  ....*....|....*....|....*....
gi 2024407468 140 AACILQVELVAKACCEYMKLHFHPSNCLA 168
Cdd:cd18265   100 ASDLLQVSKLREACVRFLEGQLHPCNCLG 128
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-169 1.73e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 79.65  E-value: 1.73e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  23 QQQQTRSSSGdgEDDIFVFEANeAWKDFHSSLLHFFEAGEL-CDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAK 101
Cdd:cd18267     2 ENRKSRASSG--SMNIYLFHKS-SYADSVLTHLNLLRQQRLfTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQ 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024407468 102 QTLIEIRD-FDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVAKACCEYMKLHFHPSNCLAV 169
Cdd:cd18267    79 DSEVNFHDsIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-166 1.88e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 76.37  E-value: 1.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYA 140
Cdd:cd18264    26 GFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLEDTLEA 105

                          90       100
                  ....*....|....*....|....*.
gi 2024407468 141 ACILQVELVAKACCEYMKLHFHPSNC 166
Cdd:cd18264   106 ASYLQVTEAIGLCSQYLINNLAPENC 131
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 164-240 2.33e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 74.28  E-value: 2.33e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024407468 164 SNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQ 240
Cdd:cd18480     4 SNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLE 80
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-130 4.71e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 74.58  E-value: 4.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  51 HSSLL-----HFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSS 125
Cdd:cd18287     5 HVHFLsedigALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYTG 84


                  ....*
gi 2024407468 126 RLTLT 130
Cdd:cd18287    85 RLTLT 89
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 163-258 1.01e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 73.06  E-value: 1.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 163 PSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 242
Cdd:cd18467     3 PGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQER 82

                          90
                  ....*....|....*.
gi 2024407468 243 ATWLDEILAQVRLPLL 258
Cdd:cd18467    83 QKYLAQLLHCVRLPLL 98
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 163-258 1.07e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 73.11  E-value: 1.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 163 PSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWL---LANP 239
Cdd:cd18456     3 PSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVkhdVDGR 82

                          90
                  ....*....|....*....
gi 2024407468 240 QHHATWLdeiLAQVRLPLL 258
Cdd:cd18456    83 RQHVPRL---MKCVRLPLL 98
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-158 1.66e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 72.76  E-value: 1.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  63 LCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSE--MAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYA 140
Cdd:cd18245    14 LCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNppKDDGSTYKIELEGISVEVMEEILDYIYTGQIKLSEDNIQDIVQA 93

                          90
                  ....*....|....*...
gi 2024407468 141 ACILQVELVAKACCEYMK 158
Cdd:cd18245    94 ADLLLMTDLKDLCCEFLE 111
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 164-257 3.33e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 71.62  E-value: 3.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 164 SNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHA 243
Cdd:cd18447     5 SNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQ 84

                          90
                  ....*....|....
gi 2024407468 244 TWLDEILAQVRLPL 257
Cdd:cd18447    85 PYMVDILAKVRFPL 98
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 161-259 4.11e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 71.41  E-value: 4.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 161 FHPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQ 240
Cdd:cd18514     1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                          90
                  ....*....|....*....
gi 2024407468 241 HHATWLDEILAQVRLPLLP 259
Cdd:cd18514    81 KRKDYLPELLRNVRLALLP 99
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-173 4.66e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 72.23  E-value: 4.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  47 WKDFHSSLLHFF----EAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFV 122
Cdd:cd18266     5 WADHSNLVLQGLneqrQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAVIDFL 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2024407468 123 YSSRLTLTVDNVQPLLYAACILQVELVAKACCEYMKLHFHPSNCLAVRSFA 173
Cdd:cd18266    85 YSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQELA 135
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-158 9.39e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 71.05  E-value: 9.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMA-------EAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDN 133
Cdd:cd18228    17 GHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASprlvlvsPAGKCVLDLHHVTVTGFAPLLEYAYTSTLSINTEN 96

                          90       100
                  ....*....|....*....|....*
gi 2024407468 134 VQPLLYAACILQVELVAKACCEYMK 158
Cdd:cd18228    97 IIDVLAAASYMQMFNVANTCSEFMK 121
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 162-259 1.27e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 69.83  E-value: 1.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 162 HPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQH 241
Cdd:cd18464     1 HPSNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPR 80

                          90
                  ....*....|....*...
gi 2024407468 242 HATWLDEILAQVRLPLLP 259
Cdd:cd18464    81 RHEVLPELLRSVRLALLP 98
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 163-257 1.79e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 69.37  E-value: 1.79e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 163 PSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 242
Cdd:cd18485     3 ASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRKSR 82

                          90
                  ....*....|....*
gi 2024407468 243 ATWLDEILAQVRLPL 257
Cdd:cd18485    83 VQHLVELLKQVRLEL 97
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 162-259 3.27e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 68.85  E-value: 3.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 162 HPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQH 241
Cdd:cd18515     1 HPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKK 80

                          90
                  ....*....|....*...
gi 2024407468 242 HATWLDEILAQVRLPLLP 259
Cdd:cd18515    81 RHCYLSELLQTVRLALLP 98
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-167 3.93e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 69.48  E-value: 3.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  52 SSLLHFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTV 131
Cdd:cd18271    13 SVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEITD 92

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2024407468 132 DNVQPLLYAACILQVELVAKACCEYMKLHFHPSNCL 167
Cdd:cd18271    93 DNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCL 128
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 162-267 5.79e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 68.26  E-value: 5.79e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 162 HPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQH 241
Cdd:cd18446     2 HPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKESE 81

                          90       100
                  ....*....|....*....|....*.
gi 2024407468 242 HATWLDEILAQVRLPLLPICFLMGVV 267
Cdd:cd18446    82 RLPLLPRVLENVRLPLLDPWYFVETV 107
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-157 6.70e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 68.04  E-value: 6.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  50 FHSSLLHFFEAGELCDVTLKVGT--KLISCHKLVLACVIPYFRAMFLSEMA-EAKQTLIEIRDFDGDAIEDLVKFVYSSR 126
Cdd:cd18294     1 FAADMKSLINNPEFSDVKFLVGPerQEIFAHKCILAARCEVFRAMFLTGPQkESTQSPLVLSDIEPEVFRAVLEFIYTNC 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2024407468 127 LTLTVDNVQPLLYAACILQVELVAKACCEYM 157
Cdd:cd18294    81 VTLSNHTVIEVLAAAVEYGLDELRKLCERFI 111
Kelch smart00612
Kelch domain;
538-584 7.93e-14

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 66.04  E-value: 7.93e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2024407468  538 CLYVVGGFDDNSPLSSVERFDPRSDKWEYVAELTTPRGGVGIATLMG 584
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 162-216 8.97e-14

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 66.15  E-value: 8.97e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2024407468 162 HPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSS 216
Cdd:cd14733     1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 62-153 3.39e-13

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 65.83  E-value: 3.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  62 ELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAA 141
Cdd:cd18314     5 EFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLA 84

                          90
                  ....*....|..
gi 2024407468 142 CILQVELVAKAC 153
Cdd:cd18314    85 SKYQVPDLEKLC 96
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 162-234 3.51e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 65.11  E-value: 3.51e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024407468 162 HPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKW 234
Cdd:cd18463     3 DPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRW 75
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 53-168 4.88e-13

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 65.99  E-value: 4.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  53 SLLHFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVD 132
Cdd:cd18263     3 SIEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWE 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2024407468 133 NVQPLLYAACILQVELVAKACCEYMKLHFHPSNCLA 168
Cdd:cd18263    83 NLFEATCTALQLQISGALALCLDFLQREISPARCLD 118
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-166 6.44e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 65.98  E-value: 6.44e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  41 FEANEAWKDFHSSLLHFFEAGELCDVTLKVG--TKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDL 118
Cdd:cd18239     1 FTSNTHSSVVLQGFDQLRGEGLLCDVTLVPGdgDETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2024407468 119 VKFVYSSRLTLTVDNVQPLLYAACILQVELVAKACCEYMKLHFHPSNC 166
Cdd:cd18239    81 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
Kelch smart00612
Kelch domain;
364-410 6.47e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 63.35  E-value: 6.47e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2024407468  364 RVYAVGGHDGNEHLGSMEVFDPLTNKWMIKASMNTKRRGIALASLGG 410
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-157 6.72e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 65.38  E-value: 6.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  49 DFHSSLLHFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSE-MAEAKQTLIEIRDFDG--DAIEDLVKFVYSS 125
Cdd:cd18292     3 EFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDwWSESKQSEIELVEDPEcaAVFEKFLRYLYTG 82

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2024407468 126 RLTLTVDNVQPLLYAACILQVELVAKACCEYM 157
Cdd:cd18292    83 QISVNLETALPLLMLADKYNVTDLKQLCVDFM 114
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 163-235 7.67e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 63.95  E-value: 7.67e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024407468 163 PSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWL 235
Cdd:cd18472     3 PANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 163-259 1.10e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 64.48  E-value: 1.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 163 PSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 242
Cdd:cd18477     3 LGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKENR 82

                          90
                  ....*....|....*..
gi 2024407468 243 ATWLDEILAQVRLPLLP 259
Cdd:cd18477    83 QKALPTVFESIRFRLLP 99
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-157 1.49e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 64.34  E-value: 1.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  65 DVTLKVG----TKLISCHKLVLACVIPYFRAMFLSEMAEAKQTlIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYA 140
Cdd:cd18282     9 DVHFIVGppggTQRIPAHKYVLATGSSVFYAMFYGGLAENKNE-IEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYA 87

                          90
                  ....*....|....*..
gi 2024407468 141 ACILQVELVAKACCEYM 157
Cdd:cd18282    88 AKKYLVPHLARACVQFL 104
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 352-397 1.60e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 62.24  E-value: 1.60e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2024407468 352 RRRHVGVISVGGRVYAVGGHDGNEHLGSMEVFDPLTNKWMIKASMN 397
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-165 1.66e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 64.76  E-value: 1.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  56 HFFEAGELCDVTLKVG----TKLISCHKLVLACVIPYFRAMFLSEMAEAKQTlIEIRDFDGDAIEDLVKFVYSSRLTLTV 131
Cdd:cd18281    15 FLFNNETLSDVHFIVGkgdnEQRIPAHKFVLSIGSAVFDAMFNGGMATTSAE-IELPDVEPAAFLALLRFLYSDEVQIGP 93

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2024407468 132 DNVQPLLYAACILQVELVAKACCEYMKLHFHPSN 165
Cdd:cd18281    94 ETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 526-571 1.93e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 61.86  E-value: 1.93e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2024407468 526 RRAGNGVSELHGCLYVVGGFDDNSPLSSVERFDPRSDKWEYVAELT 571
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
412-455 2.51e-12

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 61.81  E-value: 2.51e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2024407468  412 IYAIGGLDDNTCFSDVERYDIESDRWSAVAPMNTPRGGVGSVAL 455
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
PLN02153 PLN02153
epithiospecifier protein
 357-567 2.53e-12

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 68.47  E-value: 2.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 357 GVISVGGRVYAVGGH-DGNEHLGS-MEVFDPLTNKWMIKASMNTKRR----GIALASLGGPIYAIGGLDDNTCFSDVERY 430
Cdd:PLN02153   27 GIAVVGDKLYSFGGElKPNEHIDKdLYVFDFNTHTWSIAPANGDVPRisclGVRMVAVGTKLYIFGGRDEKREFSDFYSY 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 431 DIESDRWSAVAPMNTprggvgsvalmvslfpcRSGPGSRpAFQISSKSskqsfpvqlfQNHVYAVGG--NDGIAS----L 504
Cdd:PLN02153  107 DTVKNEWTFLTKLDE-----------------EGGPEAR-TFHSMASD----------ENHVYVFGGvsKGGLMKtperF 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024407468 505 SSVEKYDPHLDKWMEVKEMG---QRRAGNGVSELHGCLYVVGGF--------DDNSPLSSVERFDPRSDKWEYV 567
Cdd:PLN02153  159 RTIEAYNIADGKWVQLPDPGenfEKRGGAGFAVVQGKIWVVYGFatsilpggKSDYESNAVQFFDPASGKWTEV 232
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-126 2.95e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 63.71  E-value: 2.95e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024407468  54 LLHFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSR 126
Cdd:cd18345     9 LGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGK 81
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-169 3.86e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 64.21  E-value: 3.86e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  57 FFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQP 136
Cdd:cd18244    24 LYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMLTVHE 103

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2024407468 137 LLYAACILQVELVAKACCEYMKLHFHPSNCLAV 169
Cdd:cd18244   104 ILQAAMYVQLTEVVKFCCSFLLAKICLDNCAEI 136
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 163-253 4.15e-12

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 62.64  E-value: 4.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 163 PSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSD-LNIENEKQVYNAAIKWLLANPQH 241
Cdd:cd18502     3 PENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQIEVILESNQeLESINERKLCQLVLEWVQRSIEE 82

                          90
                  ....*....|..
gi 2024407468 242 HATWLDEILAQV 253
Cdd:cd18502    83 GGLDLDDLTEKV 94
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 163-256 7.59e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 61.80  E-value: 7.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 163 PSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 242
Cdd:cd18483     3 PQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQSKR 82

                          90
                  ....*....|....*
gi 2024407468 243 ATWLDEILAQ-VRLP 256
Cdd:cd18483    83 EMHLPEIFAKcIRMP 97
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 163-259 1.01e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 61.71  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 163 PSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 242
Cdd:cd18517     3 VGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKENR 82

                          90
                  ....*....|....*..
gi 2024407468 243 ATWLDEILAQVRLPLLP 259
Cdd:cd18517    83 VKSLGEIFDCIRFRLMP 99
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-158 1.58e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 61.81  E-value: 1.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIrDFDG-DAIEDLVKFVYSSRLTLTVDNVQPLLY 139
Cdd:cd18198    23 GLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEI-DFVSpEALTALLEFAYTATLTVSTANVGDILS 101

                          90
                  ....*....|....*....
gi 2024407468 140 AACILQVELVAKACCEYMK 158
Cdd:cd18198   102 AARLLEIPCVSHVCAEILD 120
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 162-239 1.70e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 60.32  E-value: 1.70e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024407468 162 HPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVE-CEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANP 239
Cdd:cd18450     2 TPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKdSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHDP 80
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 163-254 1.82e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 60.79  E-value: 1.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 163 PSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 242
Cdd:cd18455     2 AENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEER 81

                          90
                  ....*....|..
gi 2024407468 243 ATWLDEILAQVR 254
Cdd:cd18455    82 KVHLKDLMSSCW 93
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-157 2.03e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 61.49  E-value: 2.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  49 DFHSSLLHFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLT 128
Cdd:cd18326    11 DILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLDFAYTATLT 90

                          90       100
                  ....*....|....*....|....*....
gi 2024407468 129 LTVDNVQPLLYAACILQVELVAKACCEYM 157
Cdd:cd18326    91 VSTSNVGDILSAARLLEIPAVSHVCADLL 119
Kelch smart00612
Kelch domain;
585-629 2.08e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 59.11  E-value: 2.08e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2024407468  585 RIFAVGGHNGNAYLNTVEAFDPIVNRWELVGSVSHCRAGAGVAVC 629
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-157 2.09e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 61.44  E-value: 2.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYA 140
Cdd:cd18328    23 GLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAILEFAYTSTLTITTSNVKHILNA 102

                          90
                  ....*....|....*..
gi 2024407468 141 ACILQVELVAKACCEYM 157
Cdd:cd18328   103 AQMLEIQCIINVCLEIM 119
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 163-258 2.72e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 60.58  E-value: 2.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 163 PSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 242
Cdd:cd18460     3 VSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPKHR 82

                          90
                  ....*....|....*.
gi 2024407468 243 ATWLDEILAQVRLPLL 258
Cdd:cd18460    83 QHFWPELLQHVRLPFV 98
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 164-259 4.04e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 59.77  E-value: 4.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 164 SNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHA 243
Cdd:cd18516     4 SNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERT 83

                          90
                  ....*....|....*.
gi 2024407468 244 TWLDEILAQVRLPLLP 259
Cdd:cd18516    84 KALPVLLESIRFRLMP 99
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-126 4.21e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 60.62  E-value: 4.21e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024407468  52 SSLLHFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSR 126
Cdd:cd18279     7 EDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGK 81
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-153 7.16e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 59.59  E-value: 7.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  56 HFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYS---SRLTLTVD 132
Cdd:cd18297     5 HYVNNPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTggvESLDVAQD 84

                          90       100
                  ....*....|....*....|.
gi 2024407468 133 NVQPLLYAACILQVELVAKAC 153
Cdd:cd18297    85 DALELLRAASFFQLDGLKRHC 105
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-161 8.38e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 59.67  E-value: 8.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  49 DFHSSLLHFFEA----GELCDVTLKVGTKLISCHKLVLACVIPYFR-AMFLSEMAEAKQTLIEirdfDGDAIEDLVKFVY 123
Cdd:cd18222     7 DFSNSVLSHLNQlrmqGRLCDIVVNVQGQSFRAHKVVLAASSPYFRdHMSLNEMSTVSISVIK----NPTVFEQLLSFCY 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2024407468 124 SSRLTLTVDNVQPLLYAACILQVELVAKACCEYMK-LHF 161
Cdd:cd18222    83 TGRICLQLADIISYLTAASFLQMQHIIDKCTQILEgIHF 121
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 165-255 9.67e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 58.91  E-value: 9.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 165 NCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHAT 244
Cdd:cd18479     5 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQ 84

                          90
                  ....*....|.
gi 2024407468 245 WLDEILAQVRL 255
Cdd:cd18479    85 YLSSVLSQIRI 95
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 400-444 1.06e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 56.85  E-value: 1.06e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2024407468 400 RRGIALASLGGPIYAIGGLDDNTCFSDVERYDIESDRWSAVAPMN 444
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 63-146 1.56e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 57.94  E-value: 1.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  63 LCDVTLKVGTKLISCHKLVLACVIPYFRAMFLsEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAAC 142
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLK-ETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79


                  ....
gi 2024407468 143 ILQV 146
Cdd:cd18315    80 LLQI 83
Kelch smart00612
Kelch domain;
491-537 2.25e-10

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 56.03  E-value: 2.25e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2024407468  491 HVYAVGGNDGIASLSSVEKYDPHLDKWMEVKEMGQRRAGNGVSELHG 537
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 66-141 2.31e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 56.91  E-value: 2.31e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024407468  66 VTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAA 141
Cdd:cd01165     1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAA 76
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-169 2.65e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 58.75  E-value: 2.65e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  59 EAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLL 138
Cdd:cd18272    28 EDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVEELQETY 107

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2024407468 139 YAACILQVELVAKACCEYMKLHFHPSNCLAV 169
Cdd:cd18272   108 EVADMYQLTALFEECSRFLARTVQVRNCLQV 138
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 163-259 2.92e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 57.46  E-value: 2.92e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 163 PSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 242
Cdd:cd18469     5 ATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDPQAR 84

                          90
                  ....*....|....*..
gi 2024407468 243 ATWLDEILAQVRLPLLP 259
Cdd:cd18469    85 AAHLPELLSLVHLSLLT 101
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-153 4.18e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 57.56  E-value: 4.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  63 LCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAAC 142
Cdd:cd18332    19 LTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGLEARGFQLLLDFMYTSRLPLTPRTVPAVLAAAT 98

                          90
                  ....*....|.
gi 2024407468 143 ILQVELVAKAC 153
Cdd:cd18332    99 YLQMEHVVETC 109
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 58-158 4.75e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 57.30  E-value: 4.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  58 FEAGELCDVTLKVG----TKLISCHKLVLACVIPYFRAMFLSEMAEAKQTlIEIRDFDGDAIEDLVKFVYSSRLTLTVDN 133
Cdd:cd18349     3 FNNELMADVHFIVGppgaSQRVPAHKYVLAVGSSVFYAMFYGDLAEVKSE-IHIPDVEPAAFLILLKYMYSDEIDLEADT 81

                          90       100
                  ....*....|....*....|....*
gi 2024407468 134 VQPLLYAACILQVELVAKACCEYMK 158
Cdd:cd18349    82 VLATLYAAKKYIVPALAKACVNFLE 106
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-155 5.07e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 57.71  E-value: 5.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  56 HFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSR---LTLTVD 132
Cdd:cd18343    14 NLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKapnLDKMAD 93

                          90       100
                  ....*....|....*....|...
gi 2024407468 133 NvqpLLYAACILQVELVaKACCE 155
Cdd:cd18343    94 N---LLAAADKYALERL-KVMCE 112
PHA02790 PHA02790
Kelch-like protein; Provisional
 75-417 5.09e-10

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 62.37  E-value: 5.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  75 ISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEI-RDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVAKAC 153
Cdd:PHA02790   33 IIVNSTILKKLSPYFRTHLRQKYTKNKDPVTRVcLDLDIHSLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTC 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 154 CEYMKLHFHPSNCLAVRSFAESHNRIDLMDMADQYACEHFTE----VVECEDFVSvspqhLHKLLSSSDLNIENEKQVYN 229
Cdd:PHA02790  113 INFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLEleddIIDNFDYLS-----MKLILESDELNVPDEDYVVD 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 230 AAIKWLLANPQHHATWLDEILAQVRLPLLPIcflMGVvakeeivkQNLKCrdLLDEARNYHLHLSSRA---VPDFEYSI- 305
Cdd:PHA02790  188 FVIKWYMKRRNRLGNLLLLIKNVIRSNYLSP---RGI--------NNVKW--ILDCTKIFHCDKQPRKsykYPFIEYPMn 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 306 --------RTTPRKQTAGVLFCVGGRGGSGDPFRSIECYSINkNSWFFGPEMNSRRRHVGVISVGGRVYAVGGHDGNEhl 377
Cdd:PHA02790  255 mdqiidifHMCTSTHVGEVVYLIGGWMNNEIHNNAIAVNYIS-NNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNPT-- 331

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 2024407468 378 gSMEVFDPLTNKWMIKASMNTKRRGIALASLGGPIYAIGG 417
Cdd:PHA02790  332 -SVERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVIGG 370
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-158 9.94e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 56.44  E-value: 9.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTL-IEIRDFDGdaIEDLVKFVYSSRLTLTVDNVQPLLY 139
Cdd:cd18233    16 GLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKNDVFhLDIKNVGG--IGQILDFMYTSHLDLNQDNVQVMLD 93

                          90
                  ....*....|....*....
gi 2024407468 140 AACILQVELVAKACCEYMK 158
Cdd:cd18233    94 IAQCLQVQNVLNMCYTFLK 112
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-149 1.06e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 56.72  E-value: 1.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  59 EAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEM-AEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPL 137
Cdd:cd18293    11 NSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPpPAGQKVVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDV 90

                          90
                  ....*....|...
gi 2024407468 138 LYAACILQV-ELV 149
Cdd:cd18293    91 LAAARRLQIsELE 103
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-141 1.86e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 55.80  E-value: 1.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  59 EAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVY-----------SSRL 127
Cdd:cd18280    10 ESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYkdelpddvepaGSDS 89

                          90
                  ....*....|....*
gi 2024407468 128 TLTVDNV-QPLLYAA 141
Cdd:cd18280    90 SSLDTTMaQHLLAAA 104
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 58-160 2.19e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 55.36  E-value: 2.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  58 FEAGELCDVTLKVGTKLISCHKLVLaCVIPYFRAMFLSEMAEAKQTLIEIR----DFDGDAIEDLVKFVYSSRLTLTVDN 133
Cdd:cd18305    10 FLNGENSDITICALGREWKLHKIYL-CQSGYFASMFSGSWKESKETVINLEipddNITVEALNVVFGSLYRDEIEIKPSR 88

                          90       100
                  ....*....|....*....|....*..
gi 2024407468 134 VQPLLYAACILQVELVAKACCEYMKLH 160
Cdd:cd18305    89 VVSILAAATLLQLDGLIQQCSEVMKET 115
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-153 3.08e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 54.94  E-value: 3.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEmaeakQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYA 140
Cdd:cd18206    20 GLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQ-----KDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAV 94

                          90
                  ....*....|...
gi 2024407468 141 ACILQVELVAKAC 153
Cdd:cd18206    95 ATFLQMQDIVTAC 107
PLN02193 PLN02193
nitrile-specifier protein
 357-567 3.08e-09

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 59.58  E-value: 3.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 357 GVISVGGRVYAVGG-----HDGNEHLgsmEVFDPLTNKWMIKASM----NTKRRGIALASLGGPIYAIGGLDDNTCFSDV 427
Cdd:PLN02193  170 GIAQVGNKIYSFGGeftpnQPIDKHL---YVFDLETRTWSISPATgdvpHLSCLGVRMVSIGSTLYVFGGRDASRQYNGF 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 428 ERYDIESDRWSAvapmntprggvgsvalmvsLFPCRSGPGSRpAFQISSKSskqsfpvqlfQNHVYAVGGNDGIASLSSV 507
Cdd:PLN02193  247 YSFDTTTNEWKL-------------------LTPVEEGPTPR-SFHSMAAD----------EENVYVFGGVSATARLKTL 296

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024407468 508 EKYDPHLDKWMEVKEMGQR---RAGNGVSELHGCLYVVGGFdDNSPLSSVERFDPRSDKWEYV 567
Cdd:PLN02193  297 DSYNIVDKKWFHCSTPGDSfsiRGGAGLEVVQGKVWVVYGF-NGCEVDDVHYYDPVQDKWTQV 358
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-167 3.24e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 55.20  E-value: 3.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  63 LCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKqtlIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAAC 142
Cdd:cd18260    18 LCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLQR---VELNDISPLGLATVITYAYTGKLTLSLYTIGSTISAAS 94

                          90       100
                  ....*....|....*....|....*
gi 2024407468 143 ILQVELVAKACCEYMKLHFHPSNCL 167
Cdd:cd18260    95 YLQIHALVKMCCDFLMQEMNVENCM 119
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-155 3.99e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 55.24  E-value: 3.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  59 EAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAK-------QTLIEIrDFDG-DAIEDLVKFVYSSRLTLT 130
Cdd:cd18327    21 RAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGdlgagggQDVCEL-DFVGpEALGALLEFAYTATLTIS 99

                          90       100
                  ....*....|....*....|....*
gi 2024407468 131 VDNVQPLLYAACILQVELVAKACCE 155
Cdd:cd18327   100 SSNMREVLRAARLLEIPCVADACAD 124
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 573-616 7.26e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 51.84  E-value: 7.26e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2024407468 573 PRGGVGIATLMGRIFAVGGHNGNAYLNTVEAFDPIVNRWELVGS 616
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPS 44
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 54-162 1.02e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 53.80  E-value: 1.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  54 LLHFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVD- 132
Cdd:cd18286     8 LLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLPDDv 87

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2024407468 133 NVQPLLYAACILQVELVAKACCEYMKL----HFH 162
Cdd:cd18286    88 NLGELLSLADMYGLDGLKDVVAYTLRRdychFFH 121
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 64-156 1.06e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 52.88  E-value: 1.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  64 CDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTL---IEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYA 140
Cdd:cd18307     2 CDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATDELsitIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLLKG 81

                          90
                  ....*....|....*.
gi 2024407468 141 ACILQVELVAKACCEY 156
Cdd:cd18307    82 AKYFNIPRLKDHCVDF 97
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-157 1.11e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 54.20  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYA 140
Cdd:cd18261    26 GILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFAYTGQILLEPGVIQDVLAA 105

                          90
                  ....*....|....*..
gi 2024407468 141 ACILQVELVAKACCEYM 157
Cdd:cd18261   106 GSHLQLLELLSLCSHYL 122
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-158 1.15e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 53.32  E-value: 1.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAkqtLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYA 140
Cdd:cd18200    16 GKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLLLNDTNC---LVLPSVIEAAAFENLLQLIYSGRLTLCMDALPSHLLV 92

                          90
                  ....*....|....*...
gi 2024407468 141 ACILQVELVAKACCEYMK 158
Cdd:cd18200    93 ASGLQMWQVVDRCSELLK 110
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-157 1.26e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 53.51  E-value: 1.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRD--FDGDAIEDLVKFVYSSRLTLTVDNVQPLL 138
Cdd:cd18196    19 GQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLDSevVTAEAFAALIDMMYTSTLMLGESNVMDVL 98

                          90
                  ....*....|....*....
gi 2024407468 139 YAACILQVELVAKACCEYM 157
Cdd:cd18196    99 LAASHLHLNSVVKACKHYL 117
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-158 1.30e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 53.26  E-value: 1.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  53 SLLHFFE----AGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMaEAKQTLIEIRDFDGDAIEDLVKFVYSSRLT 128
Cdd:cd18212     9 TVLTNFEeqrkKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEG-EVGQSIYMLEGMVAETFGALLEFIYTGCLQ 87

                          90       100       110
                  ....*....|....*....|....*....|
gi 2024407468 129 LTVDNVQPLLYAACILQVELVAKACCEYMK 158
Cdd:cd18212    88 VGEKSLEQILATAQFLKVNDLVKAYSDYQN 117
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-158 2.07e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 53.14  E-value: 2.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDF-DGDAIEDLVKFVYSSRLTLTVDNVQPLLY 139
Cdd:cd18230    19 GILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIvTAQGFKAIIDFMYSAHLALTSKNVIEVMS 98

                          90
                  ....*....|....*....
gi 2024407468 140 AACILQVELVAKACCEYMK 158
Cdd:cd18230    99 AASYLQMTDIVQACHNFIK 117
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 163-256 2.87e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 51.67  E-value: 2.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 163 PSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIEnEKQVYNAAIKWLLANPQHH 242
Cdd:cd18476     3 PSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDELCGE-EEQVFETLMVWIRHDPKAR 81

                          90
                  ....*....|....
gi 2024407468 243 ATWLDEILAQVRLP 256
Cdd:cd18476    82 KGYIHDLFKKVRLQ 95
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-153 3.04e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 52.55  E-value: 3.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKV---GTKL-ISCHKLVLACVIPYFRAMFLSEM-AEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQ 135
Cdd:cd18211    23 GHLCDVTVQVehqGSKEeFSAHKAVLAASSKYFKEVFLNEKiSDGKNTNVMLNEIYTADFASFLEFVYTAKVEVEEDRVQ 102

                          90
                  ....*....|....*...
gi 2024407468 136 PLLYAACILQVELVAKAC 153
Cdd:cd18211   103 RMLEIAEKLKCLDLSETC 120
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 165-238 3.08e-08

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 51.19  E-value: 3.08e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024407468 165 NCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLAN 238
Cdd:cd18503     5 NCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEHN 78
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-127 3.23e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 52.18  E-value: 3.23e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAkQTLIEIRDFDGDAIEDLVKFVYSSRL 127
Cdd:cd18209    16 GQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENES-QSVFQLDFCEPDAFENVLNYIYSSSL 81
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 53-141 3.27e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 52.30  E-value: 3.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  53 SLLHFFEAGELC-DVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQT-----LIEIRDFDGDAIEDLVKFVYSSR 126
Cdd:cd18296     6 ELPFPPEQELSFpDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENngsipVVTLHDVSPEVFAIVLYYIYTDD 85

                          90
                  ....*....|....*
gi 2024407468 127 LTLTVDNVQPLLYAA 141
Cdd:cd18296    86 TDLPPENAYDVLYVA 100
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 62-155 3.42e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 52.23  E-value: 3.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  62 ELCDVTLKVGTK--LISCHKLVLACVIPYFRAMFlSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLY 139
Cdd:cd18231    13 DLCDVDIVLVRQrsTFPAHKGVLAAYSQFFHSLF-TQNKQLQRVELSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLN 91

                          90
                  ....*....|....*.
gi 2024407468 140 AACILQVELVAKACCE 155
Cdd:cd18231    92 AAAVLQMNDIAASCQE 107
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-169 7.09e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 50.95  E-value: 7.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  65 DVTLKVGTKLISCHKLVLACVIPYFRAmflsemaEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACIL 144
Cdd:cd18275     6 DLVIEVSGQRIRAHKSVLAAKSDYFRA-------RLSRDILKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFL 78

                          90       100
                  ....*....|....*....|....*
gi 2024407468 145 QVELVAKACCEYMKLHFHPSNCLAV 169
Cdd:cd18275    79 QMPCAAQCAVDAVRAQLCLGNCYEV 103
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 165-262 7.32e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 50.89  E-value: 7.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 165 NCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHAT 244
Cdd:cd18462     5 NCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVEKRIE 84

                          90
                  ....*....|....*...
gi 2024407468 245 WLDEILAQVRLPLLPICF 262
Cdd:cd18462    85 CAYDLLSSIKLDLDEIYL 102
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-158 7.76e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 51.50  E-value: 7.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTL-IEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLY 139
Cdd:cd18207    25 GRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPReLEMHTISSKVFGDILDFAYTSRIVVRLESFPELMT 104

                          90
                  ....*....|....*....
gi 2024407468 140 AACILQVELVAKACCEYMK 158
Cdd:cd18207   105 AAKFLLMRSVIDICQEVIK 123
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-158 8.74e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 50.53  E-value: 8.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  59 EAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAkqtlIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLL 138
Cdd:cd18232    14 EEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGS----VVLPESFAEVFGLLLDFFYTGELALTRENRDRVL 89

                          90       100
                  ....*....|....*....|
gi 2024407468 139 YAACILQVeLVAKACCEYMK 158
Cdd:cd18232    90 LAAKELRV-PEAVELCQRFQ 108
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-153 9.32e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 50.52  E-value: 9.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  59 EAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFlsEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLL 138
Cdd:cd18217    14 EAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQY--KDTEDNIVFLDQSQVSADGFQKLLEFIYTGNLNLDSWNVAEIH 91

                          90
                  ....*....|....*
gi 2024407468 139 YAACILQVELVAKAC 153
Cdd:cd18217    92 QAASYLGMEEVVAKC 106
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 50-151 9.38e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 50.66  E-value: 9.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  50 FHSSLLHFFEAGELCDVTLK-VGTKLISCHKLVLACVIPYFRAMFLSEmAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLT 128
Cdd:cd18311     1 FLQRLQNLFNKTEYCDLTLQfRDNEQLKVHRLVLSACTDYFNVLEQTC-EIVDDTLIMPNELQADAVVPVINFMYTGQLE 79

                          90       100
                  ....*....|....*....|...
gi 2024407468 129 LTVDNVQPLLYAACILQVELVAK 151
Cdd:cd18311    80 FEEKSYGKLLRTAKELNMTVLLK 102
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 71-165 1.06e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 51.17  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  71 GTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTlIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVA 150
Cdd:cd18348    33 GTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDE-IRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLA 111

                          90
                  ....*....|....*
gi 2024407468 151 KACCEYMKLHFHPSN 165
Cdd:cd18348   112 RACVNFLETSLSAKN 126
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-153 1.21e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 50.60  E-value: 1.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  63 LCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEirDFDGDA-IEDLVKFVYSSRLTLTVDNVQPLLYAA 141
Cdd:cd18224    26 MCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTELDVARTYVV--DFITPAnFEKVLSFIYTSELFTDLINVGVIYEVA 103

                          90
                  ....*....|..
gi 2024407468 142 CILQVELVAKAC 153
Cdd:cd18224   104 EKLGMEDLLKAC 115
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-158 1.38e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 50.41  E-value: 1.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFR-AMFLSEMAEAKQTLIEirdfDGDAIEDLVKFVYSSRLTLTVDNVQPLLY 139
Cdd:cd18220    23 GKLCDIIVHIQGQPFRAHKAVLAASSPYFRdHSALSTMSGLSISVIK----NPNVFEQLLSFCYTGRMSLQLKDVVSFLT 98

                          90
                  ....*....|....*....
gi 2024407468 140 AACILQVELVAKACCEYMK 158
Cdd:cd18220    99 AASFLQMQCVIDKCTQILE 117
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-129 1.39e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 50.66  E-value: 1.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMA-------------EAKQTLIEIRDFDGDAIEDLVKFVYSSRL 127
Cdd:cd18195    16 GLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLPlgaaavaaapgatQSPERVLELPGVKAGVFSDVLNFIYSSRV 95


                  ..
gi 2024407468 128 TL 129
Cdd:cd18195    96 AL 97
PHA02713 PHA02713
hypothetical protein; Provisional
 63-437 1.56e-07

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 54.25  E-value: 1.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  63 LCDVTLKVGT-KLISCHKLVLACVIPYFRAMFLSEM-AEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTvdNVQPLLYA 140
Cdd:PHA02713   25 LCDVIITIGDgEEIKAHKTILAAGSKYFRTLFTTPMiIRDLVTRVNLQMFDKDAVKNIVQYLYNRHISSM--NVIDVLKC 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 141 ACILQVELVAKACCEYMKLHFHPSNCLAV--RSFAESHnrIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSD 218
Cdd:PHA02713  103 ADYLLIDDLVTDCESYIKDYTNHDTCIYMyhRLYEMSH--IPIVKYIKRMLMSNIPTLITTDAFKKTVFEILFDIISTND 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 219 lNIENEKQVYNAAI--KWLlanpQHHATWLDEILA------------QVRLPL--------LPIC--FLMGVVAKEEIVK 274
Cdd:PHA02713  181 -NVYLYREGYKVTIllKWL----EYNYITEEQLLCilscidiqnldkKSRLLLysnktinmYPSCiqFLLDNKQNRNIIP 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 275 QNLkCrdLLDEARNYHLH---LSSRAVPDFEYS-IRTTPRK----QTAGV---LFCVGGRGGSGDPFRSIECYSINKNSW 343
Cdd:PHA02713  256 RQL-C--LVCHDTKYNVCnpcILVYNINTMEYSvISTIPNHiinyASAIVdneIIIAGGYNFNNPSLNKVYKINIENKIH 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 344 FFGPEMNSRRRHVGVISVGGRVYAVGGHDGNEHLGSMEVFDPLTNKWMIKASMNTKRRGIALASLGGPIYAIGG------ 417
Cdd:PHA02713  333 VELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGrtehid 412

                         410       420       430
                  ....*....|....*....|....*....|..
gi 2024407468 418 -----------LDDNTCFSD-VERYDIESDRW 437
Cdd:PHA02713  413 ytsvhhmnsidMEEDTHSSNkVIRYDTVNNIW 444
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-126 1.67e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 50.34  E-value: 1.67e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024407468  65 DVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSR 126
Cdd:cd18344    25 DCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTGK 86
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 56-154 1.74e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 49.93  E-value: 1.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  56 HFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLT-LTVDNV 134
Cdd:cd18300     2 LFLNKGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPiLEDGDC 81

                          90       100
                  ....*....|....*....|.
gi 2024407468 135 QPLLYAACILQVE-LVAKACC 154
Cdd:cd18300    82 VGLIVLANRLCLPrLVALCEQ 102
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-157 2.51e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 50.10  E-value: 2.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  57 FFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQP 136
Cdd:cd18342    16 LWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADD 95

                          90       100
                  ....*....|....*....|.
gi 2024407468 137 LLYAACILQVELVAKACCEYM 157
Cdd:cd18342    96 LLAAADKYALERLKVMCEDAL 116
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 488-524 2.64e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 47.22  E-value: 2.64e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2024407468 488 FQNHVYAVGGNDGIASLSSVEKYDPHLDKWMEVKEMG 524
Cdd:pfam01344  10 VGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-166 4.13e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 49.47  E-value: 4.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGT---KLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDF------DGDAIEDLVKFVYSSRLTLTV 131
Cdd:cd18241    21 GLFCDITLAFGGaggREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWssepgpDPDTVEAVIQYMYTGRIRVST 100

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2024407468 132 DNVQPLLYAACILQVELVAKACCEYMKLHFHPSNC 166
Cdd:cd18241   101 GNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 166-258 4.48e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 48.37  E-value: 4.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 166 CLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHATw 245
Cdd:cd18465     6 CLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPSRRAS- 84

                          90
                  ....*....|...
gi 2024407468 246 LDEILAQVRLPLL 258
Cdd:cd18465    85 ASHVLCHIRFPLM 97
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 60-157 4.74e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 48.49  E-value: 4.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  60 AGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFdgdaiEDLVKFVYSSRLTLTVDNVQPLLY 139
Cdd:cd18205    15 AGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYTLDFLSPKTF-----QQILEYAYTATLQAKVEDLDDLLY 89

                          90
                  ....*....|....*...
gi 2024407468 140 AACILQVELVAKACCEYM 157
Cdd:cd18205    90 AAEILEIEYLEEQCLKIL 107
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-158 5.88e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 48.40  E-value: 5.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  65 DVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACIL 144
Cdd:cd18298    14 DLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPPEDAIGLLDLANSY 93

                          90
                  ....*....|....
gi 2024407468 145 QVELVAKACCEYMK 158
Cdd:cd18298    94 CEERLKKLCEDIIK 107
Kelch_6 pfam13964
Kelch motif;
400-447 6.85e-07

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 46.17  E-value: 6.85e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2024407468 400 RRGIALASLGGPIYAIGGLDD-NTCFSDVERYDIESDRWSAVAPMNTPR 447
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNaSPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-165 7.09e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 48.53  E-value: 7.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  63 LCDVTLKVGTKL----ISCHKLVLACVIPYFRAMFLSEMAeAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLL 138
Cdd:cd18347    22 LSDVHFLVGKGLgsqrIPAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 100

                          90       100
                  ....*....|....*....|....*..
gi 2024407468 139 YAACILQVELVAKACCEYMKLHFHPSN 165
Cdd:cd18347   101 YTAKKYAVPALEAHCVEFLKKNLRADN 127
Kelch smart00612
Kelch domain;
316-363 8.11e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 46.01  E-value: 8.11e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2024407468  316 VLFCVGGRGGsGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVGG 363
Cdd:smart00612   1 KIYVVGGFDG-GQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 180-259 8.49e-07

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 47.61  E-value: 8.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 180 DLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLsSSDLNIENEKQVYNAAIKWLLANPQHHATwLDEILAQVRLPLLP 259
Cdd:cd14822    20 DLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELL-SRDSFCAPEVDIFNAVRRWCEHNPDSKED-AKEILEAVRLPLMS 97
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 57-145 1.06e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 47.33  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  57 FFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMfLSEMAEAKQTLIEIRDFDG--DAIEDLVKFVYSSRLTLTVDNV 134
Cdd:cd18312     3 FRDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRL-ASSSSESDPSEIELNDFPGgaEAFELVAKFCYGMPINLTATNV 81

                          90
                  ....*....|.
gi 2024407468 135 QPLLYAACILQ 145
Cdd:cd18312    82 VGLRCAAEYLE 92
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-157 1.15e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 47.75  E-value: 1.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  63 LCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEM-AEAKQTLIEIRDFDGdaIEDLVKFVYSSRLTLTVDNVQPLLYAA 141
Cdd:cd18277    27 LCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQAdAELNITLPEEVTVKG--FEPLIQFAYTAKLILSKDNVDEVCKCV 104

                          90
                  ....*....|....*.
gi 2024407468 142 CILQVELVAKACCEYM 157
Cdd:cd18277   105 EFLSVHNIEESCFQFL 120
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-129 1.49e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 47.48  E-value: 1.49e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTL 129
Cdd:cd18223    16 GILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEIWISSHVLELPDLKAEVFAEILNFIYSSKVVV 84
PLN02193 PLN02193
nitrile-specifier protein
 356-526 1.56e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 51.11  E-value: 1.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 356 VGVISVGGRVYAVGGHDGNEHLGSMEVFDPLTNKWMIKASMN---TKRRGIALASLGGPIYAIGGLDDNTCFSDVERYDI 432
Cdd:PLN02193  222 VRMVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNI 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 433 ESDRWSAVApmnTPRGGvgsvalmvslFPCRSGPGsrpafqissksskqsfpVQLFQNHVYAVGGNDGiASLSSVEKYDP 512
Cdd:PLN02193  302 VDKKWFHCS---TPGDS----------FSIRGGAG-----------------LEVVQGKVWVVYGFNG-CEVDDVHYYDP 350

                         170
                  ....*....|....
gi 2024407468 513 HLDKWMEVKEMGQR 526
Cdd:PLN02193  351 VQDKWTQVETFGVR 364
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-153 1.79e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 47.18  E-value: 1.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  49 DFHSSLLHFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLT 128
Cdd:cd18215     5 DVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPEIEPEGFRILLDFMYTSRLN 84

                          90       100
                  ....*....|....*....|....*
gi 2024407468 129 LTVDNVQPLLYAACILQVELVAKAC 153
Cdd:cd18215    85 LREGNIMAVMATAMYLQMEHVVDTC 109
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 60-167 1.82e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 47.27  E-value: 1.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  60 AGELCDVTLKVGTKLISCHKLVLACVIPYFRAMF---LSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQP 136
Cdd:cd18258    14 AKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIkrsSRDSGGGEKLELTMSNINADVLELLLEFVYTGSLIIDSANAKT 93

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2024407468 137 LLYAACILQVELVAKACCEYMKLHFHPSNCL 167
Cdd:cd18258    94 LLEAANKFQFHTFCKVCVSFLEKQLTASNCL 124
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-155 1.91e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 46.95  E-value: 1.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFlSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYA 140
Cdd:cd18204    16 GEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLF-KKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSS 94

                          90
                  ....*....|....*
gi 2024407468 141 ACILQVELVAKACCE 155
Cdd:cd18204    95 GQILGIRFLDKLCSQ 109
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 54-123 1.92e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 47.38  E-value: 1.92e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024407468  54 LLHFFEA--GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDF--DGDAIEDLVKFVY 123
Cdd:cd18309     9 MEAFLESvgGDFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMvpSRQAFDSLLRYIY 82
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 164-239 3.07e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 45.57  E-value: 3.07e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024407468 164 SNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANP 239
Cdd:cd18474     4 NNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDADP 79
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-153 3.61e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 46.09  E-value: 3.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  51 HSSLLHFFE----AGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSemaEAKQTLIEIRDFDGDAIEDLVKFVYSSR 126
Cdd:cd18218     2 SDRLLHLAArlrpAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTN---PNPGQWCLGEGISPSTFKQLLDFVYGES 78

                          90       100
                  ....*....|....*....|....*..
gi 2024407468 127 LTLTVDNVQPLLYAACILQVELVAKAC 153
Cdd:cd18218    79 VEVQPGELRPLLEAARALEVESLEEAC 105
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 63-156 4.13e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 46.32  E-value: 4.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  63 LCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAAC 142
Cdd:cd18352    13 LSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAAD 92

                          90
                  ....*....|....
gi 2024407468 143 ILQVELVaKACCEY 156
Cdd:cd18352    93 QYLLEGL-KRLCEY 105
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-153 5.29e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 45.62  E-value: 5.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  50 FHSSLLHFFEA----GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEakqtlIEIRDF-DGDAIEDLVKFVYS 124
Cdd:cd18229     1 FSKSLLETLNAqrlgGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSE-----IEVPPVvPAQTVRQLVEFMYS 75

                          90       100
                  ....*....|....*....|....*....
gi 2024407468 125 SRLTLTVDNVQPLLYAACILQVELVAKAC 153
Cdd:cd18229    76 GSLVVAQSEALQILTAASILQIKTVIDEC 104
Kelch_6 pfam13964
Kelch motif;
527-574 5.94e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 43.86  E-value: 5.94e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2024407468 527 RAGNGVSELHGCLYVVGGFDD-NSPLSSVERFDPRSDKWEYVAELTTPR 574
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNaSPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-153 6.58e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 45.83  E-value: 6.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAK-QTLIEIRdfdgdAIEDLVKFVYSSRLTLTVDNVQPLLY 139
Cdd:cd18208    23 GHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEiPSVVSVQ-----SVQKLIDFMYSGVLRVSQSEALQILT 97

                          90
                  ....*....|....
gi 2024407468 140 AACILQVELVAKAC 153
Cdd:cd18208    98 AASILQIKTVIDEC 111
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 64-153 6.84e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 45.59  E-value: 6.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  64 CDVTLKVGTKLISCHKLVLACVIPYFRaMFLSEMAE--AKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAA 141
Cdd:cd18329    22 CDCSILVEGQVFKAHRNVLFASSGYFK-MLLSQNAKetGQPTVATFDVFSPDTFTIILDFVYSGKLSLTSQNVIEVMSAA 100

                          90
                  ....*....|..
gi 2024407468 142 CILQVELVAKAC 153
Cdd:cd18329   101 SYLQMTDVISVC 112
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-158 6.97e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 45.70  E-value: 6.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  49 DFHSSLLHFF----EAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAeAKQTLIEIrdFDGDAIEDLVKFVYS 124
Cdd:cd18227     7 DFSSTILQKLnqqrQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDQVLLKNS-RRIVLPDV--MNPRVFENILLSCYT 83

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2024407468 125 SRLTLTVDNVQPLLYAACILQVELVAKACCEYMK 158
Cdd:cd18227    84 GRLVLPAPEIVSYLTAASFLQMWHVVDKCTELLE 117
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 64-157 9.03e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 45.42  E-value: 9.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  64 CDVTLKVGTKLISCHKLVLACVIPYFRAMFlsemaeaKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACI 143
Cdd:cd18243    33 CDVTLTAQGQQFHCHKAVLASCSQYFRSLF-------SINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKI 105

                          90
                  ....*....|....
gi 2024407468 144 LQVELVAKACCEYM 157
Cdd:cd18243   106 LHIPQVTKLCVQFL 119
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 165-235 9.10e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 44.87  E-value: 9.10e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024407468 165 NCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWL 235
Cdd:cd18470     5 NCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWL 75
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-165 9.38e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 45.43  E-value: 9.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  25 QQTRSSSGdgEDDIFVFEaNEAWKDFHssllhfFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTl 104
Cdd:cd18346     3 QATKSSLK--ERFAFLFN-NELLSDVR------FVVGKGRPRGPGPGAQRIPAHRFVLAAGSAVFDAMFNGGMATTSAE- 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024407468 105 IEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVAKACCEYMKLHFHPSN 165
Cdd:cd18346    73 IELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 133
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-156 1.03e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 45.41  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSemaeAKQTLIEI-RDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLY 139
Cdd:cd18290    25 GLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELpAAVQPQSFQQILSFCYTGRLSMNVGDQFLLMY 100

                          90
                  ....*....|....*..
gi 2024407468 140 AACILQVELVAKACCEY 156
Cdd:cd18290   101 TAGFLQIQEIMEKGTEF 117
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 193-235 1.10e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 43.72  E-value: 1.10e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2024407468 193 FTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWL 235
Cdd:cd18493    32 FEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 65-125 1.22e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 44.20  E-value: 1.22e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024407468  65 DVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAE----AKQTLIEIRDFDGDAIEDLVKFVYSS 125
Cdd:cd18301    20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTsedaVGCDVVHIEKVPPEIFEQLLQFIYTD 84
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 65-142 1.29e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 43.66  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  65 DVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRD--FDGDAIEDLVKFVYSSRLTLT-VDNVQPLLYAA 141
Cdd:cd18190     1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEEngISIEAMRAVIDFSVTGRLDLFsVENVHEVLELA 80


                  .
gi 2024407468 142 C 142
Cdd:cd18190    81 S 81
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 161-248 1.46e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 43.80  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 161 FHPSNCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVsPQHL-HKLLSSSDLNIENEKQVYNAAIKWLLANP 239
Cdd:cd18451     1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTL-PFHLvRDWLSDAEITVDSEEVLFEAVLKWVQRNA 79


                  ....*....
gi 2024407468 240 QHHATWLDE 248
Cdd:cd18451    80 EERERYFEE 88
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-153 1.52e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 44.82  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRaMFLSEMAEAKQ-TLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLY 139
Cdd:cd18323    21 GFLCDCTVLVGSTQFLAHRAVLASCSPFFH-MFYKEQLDKRDlVCINNEIVTAPAFSLLLEFMYEGRLSFNDTPVEDVLA 99

                          90
                  ....*....|....
gi 2024407468 140 AACILQVELVAKAC 153
Cdd:cd18323   100 AASYLHMNDIVKVC 113
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-157 1.86e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 43.61  E-value: 1.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  63 LCDVTLKVGTKLISCHKLVLACVIPYframFLSEMAEAKQTLIEI---RDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLY 139
Cdd:cd18955     1 LCDVTIVVEDQRFRAHRAVLAACSDY----FLSRVVGQTDGDLVItlpEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCR 76

                          90
                  ....*....|....*...
gi 2024407468 140 AACILQVELVAKACCEYM 157
Cdd:cd18955    77 CAEFLGVHNIEKACFDFL 94
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-157 2.05e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 44.55  E-value: 2.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  63 LCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEmAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAAC 142
Cdd:cd18278    31 LCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQ-TENDLVVSLPEEVTARGFGPLLQFAYTAKLLLSRENIQEVIRCAE 109

                          90
                  ....*....|....*
gi 2024407468 143 ILQVELVAKACCEYM 157
Cdd:cd18278   110 FLRMHNLEDSCFRFL 124
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 64-157 2.56e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 43.95  E-value: 2.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  64 CDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRD-FDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAAC 142
Cdd:cd18199    19 CDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDvFSSDAFSIILDFVYSGKLSLTSQNVIEVMSAAS 98

                          90
                  ....*....|....*
gi 2024407468 143 ILQVELVAKACCEYM 157
Cdd:cd18199    99 YLQMTDVINVCKTFI 113
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 164-254 2.77e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 43.26  E-value: 2.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 164 SNCLAVRSFAESHNRIDLMDMADQYACEHFTE-VVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 242
Cdd:cd18482     4 SNCAGILKFADAFDNRELKSKALAFIARNFQQlLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANLKER 83

                          90
                  ....*....|..
gi 2024407468 243 ATWLDEILAQVR 254
Cdd:cd18482    84 AASAAEVLKCVR 95
PLN02153 PLN02153
epithiospecifier protein
 317-532 3.15e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 46.52  E-value: 3.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 317 LFCVGGRGGSGDPF-RSIECYSINKNSWFFGPEMNSRRR----HVGVISVGGRVYAVGGHDGNEHLGSMEVFDPLTNKWM 391
Cdd:PLN02153   35 LYSFGGELKPNEHIdKDLYVFDFNTHTWSIAPANGDVPRisclGVRMVAVGTKLYIFGGRDEKREFSDFYSYDTVKNEWT 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 392 IKASMNTK-----RRGIALASLGGPIYAIGGLDDN------TCFSDVERYDIESDRWSAVapmntPRGGVGsvalmvslF 460
Cdd:PLN02153  115 FLTKLDEEggpeaRTFHSMASDENHVYVFGGVSKGglmktpERFRTIEAYNIADGKWVQL-----PDPGEN--------F 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 461 PCRSGPGsrpafqissksskqsFPVqlFQNHVYAV---------GGNDGIASlSSVEKYDPHLDKWMEVKEMGQRRAGNG 531
Cdd:PLN02153  182 EKRGGAG---------------FAV--VQGKIWVVygfatsilpGGKSDYES-NAVQFFDPASGKWTEVETTGAKPSARS 243


                  .
gi 2024407468 532 V 532
Cdd:PLN02153  244 V 244
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-157 3.42e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 43.38  E-value: 3.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  63 LCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEA-KQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAA 141
Cdd:cd18330    18 FCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSgRHSTASLDIVTSEAFSIILDFLYSGKLDLCSENVIEVMSAA 97

                          90
                  ....*....|....*.
gi 2024407468 142 CILQVELVAKACCEYM 157
Cdd:cd18330    98 SYLQMTDVVNFCKGYI 113
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-138 3.53e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 43.40  E-value: 3.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  53 SLLHFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVD 132
Cdd:cd18353    10 SLKKEFDSPETSDLKFRVDGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMKEVIEIDQFSYPVYRAFLEYLYTDSVDLPPE 89


                  ....*.
gi 2024407468 133 NVQPLL 138
Cdd:cd18353    90 DAIGLL 95
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-153 5.00e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 43.27  E-value: 5.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  59 EAGELCDVTLKVGTKLISCHKLVLACVIPYFRaMFLSEMAEAKqtliEIRDFDGD-----AIEDLVKFVYSSRLTLTVDN 133
Cdd:cd18194    19 SQGFLCDCTVLVGSAQFPAHRAVLASCSMYFH-LFYRDRLDKR----DLVRLNSDivtapAFGLLLDFMYEGRLALRDLP 93

                          90       100
                  ....*....|....*....|
gi 2024407468 134 VQPLLYAACILQVELVAKAC 153
Cdd:cd18194    94 VEDVLAAASYLHMYDIVKVC 113
PRK14131 PRK14131
N-acetylneuraminate epimerase;
516-603 8.01e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 45.39  E-value: 8.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 516 KWMEVKEM-GQRRAGNGVSELHGCLYVVGGF----DDNSP--LSSVERFDPRSDKWEYVAElTTPRGGVGIATLM---GR 585
Cdd:PRK14131   63 GWTKIAAFpGGPREQAVAAFIDGKLYVFGGIgktnSEGSPqvFDDVYKYDPKTNSWQKLDT-RSPVGLAGHVAVSlhnGK 141

                          90       100
                  ....*....|....*....|.
gi 2024407468 586 IFAVGGHNG---NAYLNTVEA 603
Cdd:PRK14131  142 AYITGGVNKnifDGYFEDLAA 162
Kelch_6 pfam13964
Kelch motif;
353-400 8.43e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.40  E-value: 8.43e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2024407468 353 RRHVGVISVGGRVYAVGG-HDGNEHLGSMEVFDPLTNKWMIKASMNTKR 400
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-158 9.55e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 42.25  E-value: 9.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  59 EAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQ----TLIEIRDFDGDAIedLVKFVYSSRLTLTVDNV 134
Cdd:cd18201    17 KKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDqttvTHLDVVAVQGFSV--ILDFMYSGNLVLTSQNA 94

                          90       100
                  ....*....|....*....|....
gi 2024407468 135 QPLLYAACILQVELVAKACCEYMK 158
Cdd:cd18201    95 IEVMSVASYLQMTEVVQSCRNFIK 118
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 60-153 9.75e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 42.15  E-value: 9.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  60 AGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQ-TLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLL 138
Cdd:cd18202    16 NNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKGAVSSHeAVVDLSGFCKSSFLPLLEFAYTSELTFDFCSMAEVA 95

                          90
                  ....*....|....*
gi 2024407468 139 YAACILQVELVAKAC 153
Cdd:cd18202    96 MLARHLFMNEVLEIC 110
PRK14131 PRK14131
N-acetylneuraminate epimerase;
342-454 1.01e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 45.01  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 342 SWFFGPEMNSRrrHVGVISVGGRvYAVGGHDGNE---HLGSMEV------FDPLTNKWM-IKASMNTKRRGIALASLGGP 411
Cdd:PRK14131   10 AAASSFAANAE--QLPDLPVPFK-NGTGAIDNNTvyvGLGSAGTswykldLNAPSKGWTkIAAFPGGPREQAVAAFIDGK 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2024407468 412 IYAIGGLDDN------TCFSDVERYDIESDRWSAVaPMNTPRGGVGSVA 454
Cdd:PRK14131   87 LYVFGGIGKTnsegspQVFDDVYKYDPKTNSWQKL-DTRSPVGLAGHVA 134
Kelch_3 pfam13415
Galactose oxidase, central domain;
409-447 1.03e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 40.35  E-value: 1.03e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2024407468 409 GGPIYAIGGLDD--NTCFSDVERYDIESDRWSAVAPMNTPR 447
Cdd:pfam13415   1 GDKLYIFGGLGFdgQTRLNDLYVYDLDTNTWTQIGDLPPPR 41
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 61-124 1.04e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 41.97  E-value: 1.04e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024407468  61 GELCDVTLK-VGTKLISCHKLVLACVIPYFRAMFLSEMAE-AKQTLIEIrDFDGDAIEDLVKFVYS 124
Cdd:cd18302     3 SDLYDVTIVsEDGKEFPCHKCVLVARLEYFHSMLSSSWIEaSSCSALTM-PIPSDILEIILDYLYT 67
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-153 1.14e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 42.27  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  56 HFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMfLSEMAEAKQTLIEIRDFDGDAIEDLVKFVY---SSRLTLTVD 132
Cdd:cd18351    17 HFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKAL-LSNKPSAENTCIEISYVKYHIFQLVMQYLYcggTESLLIKNN 95

                          90       100
                  ....*....|....*....|.
gi 2024407468 133 NVQPLLYAACILQVELVAKAC 153
Cdd:cd18351    96 EIMELLSAAKFFQLEALQRHC 116
BACK_KLHL36 cd18475
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...
 165-259 2.45e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350550  Cd Length: 100  Bit Score: 40.60  E-value: 2.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468 165 NCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFV-SVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQ--H 241
Cdd:cd18475     5 NYLYLQELASIYSLERLDSFIDSFILQNFGTLSFTPDFLqNVSMQKLCQYLSSNQVQHECEHDLLQAALQWLTQSPEreN 84

                          90
                  ....*....|....*...
gi 2024407468 242 HATWLdeiLAQVRLPLLP 259
Cdd:cd18475    85 EAYQV---LSNIHFPLIP 99
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-158 2.63e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 41.11  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEmaeakqTLIeirDFDGDAI-----EDLVKFVYSSRLtLTVD--- 132
Cdd:cd18334    19 GFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHD------NLI---NLDTDMVnptvfRQILDFIYTGKL-LTSDqpg 88

                          90       100
                  ....*....|....*....|....*...
gi 2024407468 133 --NVQPLLYAACILQVELVAKACCEYMK 158
Cdd:cd18334    89 eqNFNALLTAASYLQLHDLAALCRKKLK 116
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-153 3.27e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 41.02  E-value: 3.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  63 LCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEirdFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAAC 142
Cdd:cd18203    25 FCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNPSSELQVSLM---HSSRVVADLLLSCYTGALEFSVRDIVNYLTAAS 101

                          90
                  ....*....|.
gi 2024407468 143 ILQVELVAKAC 153
Cdd:cd18203   102 YLQMEHVVEKC 112
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-153 3.45e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 40.95  E-value: 3.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  59 EAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLieirDFDGD-----AIEDLVKFVYSSRLTLTVDN 133
Cdd:cd18956    19 ELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGGRDTV----RLNGDivtapAFGRLLDFMYEGRLDLRSLP 94

                          90       100
                  ....*....|....*....|
gi 2024407468 134 VQPLLYAACILQVELVAKAC 153
Cdd:cd18956    95 VEDVLAAASYLHMYDIVKVC 114
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-166 4.36e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 40.38  E-value: 4.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  50 FHSSLLHF----FEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEakqtlIEIRDFDGDAIEDLVKFVYSS 125
Cdd:cd18303     1 FISRLLKTvaslFDKELYSDITIKLADKSIPAHKFVLAARSEKWSNENLASTNE-----LDLSDISYEVVLALLRWLYTD 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2024407468 126 RLTLTVDNVQ--PLLYAACILQVELVAKACCEYMKLHFHPSNC 166
Cdd:cd18303    76 ELDLTLDDEFllELMKAAKRFQLTDLVERCERALMSSVNVDNC 118
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 165-235 4.60e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 39.71  E-value: 4.60e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024407468 165 NCLAVRSFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWL 235
Cdd:cd18449     5 NCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWL 75
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-157 5.36e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 39.82  E-value: 5.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  49 DFHSSLLHFF----EAGELCDVTLKVGTKLISCHKLVLACVIPYFR-AMFLSEMAEAKQTLIeirdFDGDAIEDLVKFVY 123
Cdd:cd18210     3 EITSSLLESLnqqrMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHdQVLLKNMSSISLPGV----MDPGAFESVLASAY 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2024407468 124 SSRLTLTVDNVQPLLYAACILQVELVAKACCEYM 157
Cdd:cd18210    79 TGKLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-157 5.70e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 40.23  E-value: 5.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  63 LCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAAC 142
Cdd:cd18331    24 LTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFNILLDFMYTSRLNLREGNIMAVMATAM 103

                          90
                  ....*....|....*
gi 2024407468 143 ILQVELVAKACCEYM 157
Cdd:cd18331   104 YLQMEHVVDTCRKFI 118
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 58-172 6.31e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 39.93  E-value: 6.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  58 FEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQpl 137
Cdd:cd18295    14 LEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTGRLEIHVDDVE-- 91

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2024407468 138 lyaacilQVELVAKACCEYMKLHFHPSNCLAVRSF 172
Cdd:cd18295    92 -------DCKRLAKQCRLEELIEELEAKCKKVREF 119
Kelch_3 pfam13415
Galactose oxidase, central domain;
362-408 8.41e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 37.65  E-value: 8.41e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2024407468 362 GGRVYAVGG--HDGNEHLGSMEVFDPLTNKWMIKASMNTKRRGIALASL 408
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-157 1.02e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 39.63  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDfdgDAIEDLVKFVYSSRLTLTVDNVQPLLYA 140
Cdd:cd18289    27 GLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPATVPP---ACFQQILSFCYTGKLTMAASEQLVVMYT 103

                          90
                  ....*....|....*..
gi 2024407468 141 ACILQVELVAKACCEYM 157
Cdd:cd18289   104 AGFLQIQHIVERGTDLM 120
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 315-350 1.10e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 1.10e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2024407468 315 GVLFCVGGRGGsGDPFRSIECYSINKNSWFFGPEMN 350
Cdd:pfam01344  12 GKIYVIGGFDG-NQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-153 1.21e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 39.25  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYA 140
Cdd:cd18325    21 GFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQLDKRDIVHLNSDIVTAPAFSLLLEFMYEGKLEFSSLPVEDVLAA 100

                          90
                  ....*....|...
gi 2024407468 141 ACILQVELVAKAC 153
Cdd:cd18325   101 ASYLHMYDIVKVC 113
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 54-156 1.59e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 38.35  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  54 LLHFFEAGELCDVTLKV-GTKLISCHKLVLACVIPYFRAMFLSemaeakQTLIEI-RDFDGDAIEDLVKFVYSSRLTLTV 131
Cdd:cd18299     3 LRNLLHSPSCADVVFILqGGVRIFAHRIVLAAASSVFADLFLM------MTVVTLdSDITPEAFRRVLEFLYTGVLDENE 76

                          90       100
                  ....*....|....*....|....*.
gi 2024407468 132 DNVQPLLYAACILQV-ELVakACCEY 156
Cdd:cd18299    77 DDLKELKDAAELLELfDLV--MMCTN 100
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-153 2.36e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 38.68  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  56 HFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQT--LIEIRDFDGDAIEDLVKFVY---SSRLTLT 130
Cdd:cd18350    17 HFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTNKSEQESQGskTIEISDIKYHIFQMLMQYLYyggTESMEIP 96

                          90       100
                  ....*....|....*....|...
gi 2024407468 131 VDNVQPLLYAACILQVELVAKAC 153
Cdd:cd18350    97 IADVLELLSAASLFQLDALQRHC 119
Kelch_3 pfam13415
Galactose oxidase, central domain;
539-574 3.21e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 36.11  E-value: 3.21e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2024407468 539 LYVVGGFDD--NSPLSSVERFDPRSDKWEYVAELTTPR 574
Cdd:pfam13415   4 LYIFGGLGFdgQTRLNDLYVYDLDTNTWTQIGDLPPPR 41
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 50-141 3.71e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 37.19  E-value: 3.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  50 FHSSLLHFFEAGELCDVTLKVGTKLISCHKLVLACVIPYFRamflSEMAEAKQTLIEIR-DFDGDAIEDLVKFVYSSRLT 128
Cdd:cd18262     5 FFGEAQRLREQRLLLDETVSVGGRSYGVHSVILAAVSSLFR----ERLLGSNGPLPPLSlEVTPVGWEAVLTFAYTGVLG 80

                          90
                  ....*....|...
gi 2024407468 129 LTVDNVQPLLYAA 141
Cdd:cd18262    81 RNPATVGDILVAA 93
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 526-570 4.06e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 35.77  E-value: 4.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2024407468 526 RRAGNGVSELHGCLYVVGGFDDNSPLSS--VERFDPRSDKWEYVAEL 570
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLSSsdVLVYDPETNVWTEVPRL 47
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-127 5.48e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 37.28  E-value: 5.48e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024407468  59 EAGELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEMAEAKQtlIEIRDFDGDAIEDLVKFVYSSRL 127
Cdd:cd18193    17 EFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFVHQTSECVR--LKPTDIQPDIFSYLLHLMYTGKM 83
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-160 5.68e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 37.13  E-value: 5.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024407468  61 GELCDVTLKVGTKLISCHKLVLACVIPYFRAMFLSEmaeakqTLIEIrDFDG---DAIEDLVKFVYSSRL---TLTVDNV 134
Cdd:cd18216    18 GFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHD------NLIHL-DQDMvspTVFQQILDFIYTGKLldsLFEEPNL 90

                          90       100
                  ....*....|....*....|....*.
gi 2024407468 135 QPLLYAACILQVELVAKACCEYMKLH 160
Cdd:cd18216    91 SEVLAAANYLQLPDLAALCRSKLKRG 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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