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Conserved domains on  [gi|2062451169|ref|XP_042071098|]
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zinc finger protein 513 isoform X2 [Haplochromis burtoni]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 12142424)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  22803940|11361095|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
123-148 1.35e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.35e-05
                          10        20
                  ....*....|....*....|....*.
gi 2062451169 123 HLKRHMRTHDGQKPYRCPVCPYASAQ 148
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
352-375 2.87e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 2.87e-05
                          10        20
                  ....*....|....*....|....
gi 2062451169 352 NLKRHLRVHTGEKPYQCPSCSYAC 375
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
151-176 3.13e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.13e-05
                          10        20
                  ....*....|....*....|....*.
gi 2062451169 151 NLQRHARTHTGEKPYRCHQCSYACSS 176
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
336-406 4.73e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 4.73e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2062451169 336 KPHRCPHCPYTSSHLDNLKRHLRVHTGEKPYQC--PSCSYACGNLANLRRHERIHSGAKPFHCSICGYSCNQS 406
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSK 104
zf-H2C2_2 pfam13465
Zinc-finger double domain;
408-431 8.60e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 8.60e-05
                          10        20
                  ....*....|....*....|....
gi 2062451169 408 NLKRHMLRHTGEKPYACGECGYTT 431
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
123-148 1.35e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.35e-05
                          10        20
                  ....*....|....*....|....*.
gi 2062451169 123 HLKRHMRTHDGQKPYRCPVCPYASAQ 148
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
352-375 2.87e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 2.87e-05
                          10        20
                  ....*....|....*....|....
gi 2062451169 352 NLKRHLRVHTGEKPYQCPSCSYAC 375
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
151-176 3.13e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.13e-05
                          10        20
                  ....*....|....*....|....*.
gi 2062451169 151 NLQRHARTHTGEKPYRCHQCSYACSS 176
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
336-406 4.73e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 4.73e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2062451169 336 KPHRCPHCPYTSSHLDNLKRHLRVHTGEKPYQC--PSCSYACGNLANLRRHERIHSGAKPFHCSICGYSCNQS 406
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSK 104
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
338-362 7.68e-05

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 39.46  E-value: 7.68e-05
                          10        20
                  ....*....|....*....|....*
gi 2062451169 338 HRCPHCPYTSSHLDNLKRHLRVHTG 362
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
408-431 8.60e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 8.60e-05
                          10        20
                  ....*....|....*....|....
gi 2062451169 408 NLKRHMLRHTGEKPYACGECGYTT 431
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
123-148 1.35e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.35e-05
                          10        20
                  ....*....|....*....|....*.
gi 2062451169 123 HLKRHMRTHDGQKPYRCPVCPYASAQ 148
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
352-375 2.87e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 2.87e-05
                          10        20
                  ....*....|....*....|....
gi 2062451169 352 NLKRHLRVHTGEKPYQCPSCSYAC 375
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
151-176 3.13e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.13e-05
                          10        20
                  ....*....|....*....|....*.
gi 2062451169 151 NLQRHARTHTGEKPYRCHQCSYACSS 176
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
336-406 4.73e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 4.73e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2062451169 336 KPHRCPHCPYTSSHLDNLKRHLRVHTGEKPYQC--PSCSYACGNLANLRRHERIHSGAKPFHCSICGYSCNQS 406
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSK 104
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
338-362 7.68e-05

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 39.46  E-value: 7.68e-05
                          10        20
                  ....*....|....*....|....*
gi 2062451169 338 HRCPHCPYTSSHLDNLKRHLRVHTG 362
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
408-431 8.60e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 8.60e-05
                          10        20
                  ....*....|....*....|....
gi 2062451169 408 NLKRHMLRHTGEKPYACGECGYTT 431
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
380-405 3.33e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.33e-04
                          10        20
                  ....*....|....*....|....*.
gi 2062451169 380 NLRRHERIHSGAKPFHCSICGYSCNQ 405
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
105-396 1.12e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451169 105 APKLYSCSLCTFTSRYSNHLKRHMRTHDGQKPYRCPVCPYASAQ--LVNLQRHARTHTGEKPYRCHQCSY-----ACSSL 177
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHNNPSDLNSKSLPlsnskASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451169 178 GNLRRHQRMhTQERPQRREKEKRRGRRKKANGDAEEVMSDLTLRVS--------QDSAYLQTLGGLGSPSGPLPVLLFPL 249
Cdd:COG5048   110 LSSSSSNSN-DNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpQSNSLHPPLPANSLSKDPSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451169 250 CCRV-CGLTLEESDLEGDKAegEVEGDGGQVCRRCSkDNSRAPCSRDVSRGSRRVQRSNKLYRCPH--------CPFLSH 320
Cdd:COG5048   189 SSNVsTSIPSSSENSPLSSS--YSIPSSSSDQNLEN-SSSSLPLTTNSQLSPKSLLSQSPSSLSSSdssssaseSPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451169 321 YPNHLARHSHVHSEE-------KPHRCPHCPYTSSHLDNLKRHLR--VHTGE--KPYQCPS--CSYACGNLANLRRHERI 387
Cdd:COG5048   266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345


                  ....*....
gi 2062451169 388 HSGAKPFHC 396
Cdd:COG5048   346 HTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
134-424 1.15e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451169 134 QKPYRCPVCPYASAQLVNLQRHARTHTGEKPyrcHQCSY-----ACSSLGNLRRHQRMHTQERPQRREKEKRRGRRKKAN 208
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKP---SQCSYsgcdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451169 209 GDAEE------VMSDLTLRVSQDSAYLQTLgglgsPSGPLPVLLFPLCCRVCGL----TLEESDLEGDKAEGEVEGDGGQ 278
Cdd:COG5048   108 SSLSSsssnsnDNNLLSSHSLPPSSRDPQL-----PDLLSISNLRNNPLPGNNSssvnTPQSNSLHPPLPANSLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451169 279 VCRRCSKDNSR------APCSRDVSRGSRRVQRSNKLYR-------CPHCPFLSHYPNHLARHSHVHSEEKPHRCPHCPY 345
Cdd:COG5048   183 NLSLLISSNVStsipssSENSPLSSSYSIPSSSSDQNLEnsssslpLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451169 346 TSSHLDNLKRHLRVHTGE-------KPYQCPSCSYACGNLANLRRHER--IHSG--AKPFHC--SICGYSCNQSMNLKRH 412
Cdd:COG5048   263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCpySLCGKLFSRNDALKRH 342

                         330
                  ....*....|..
gi 2062451169 413 MLRHTGEKPYAC 424
Cdd:COG5048   343 ILLHTSISPAKE 354
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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