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Conserved domains on  [gi|2073625839|ref|XP_042573207|]
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uncharacterized protein LOC122135972 [Cyprinus carpio]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
OTU_CeDUB-like cd22755
OTU (ovarian tumor) domain of Caenorhabditis elegans deubiquitylating enzyme with USP/UBP and ...
94-219 1.38e-56

OTU (ovarian tumor) domain of Caenorhabditis elegans deubiquitylating enzyme with USP/UBP and OTU domains, and similar proteins; This subfamily is composed of mostly uncharacterized proteins containing an OTU domain, similar to Caenorhabditis elegans deubiquitylating enzyme with USP/UBP and OTU domains. OTU domain-containing proteins function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation. They belong to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad.


:

Pssm-ID: 438592 [Multi-domain]  Cd Length: 132  Bit Score: 191.71  E-value: 1.38e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839   94 CKTVSILGDGNCFFRAVAQVICGTQKPHRAVRLAIVKHMELHSVQYKNLLRCQYASMEDYLSKSKMRFVGSWATELEIQA 173
Cdd:cd22755      1 CKTIKIVGDGNCFFRALSYAITGSEKYHRKIRKAIVDFLEKNPDEFRNLLRSDYESVEEYLEKSRMRYDGTWATDVEIFA 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2073625839  174 MANYLGVDIYTYHNE--KWLQYSCMHE----RTCNQGIYLQHCNENHYEVVV 219
Cdd:cd22755     81 AATLLGVDIYVYSKGgyKWLLYSPRFKlgkrNGSREAIYLKNTNGNHFEPVV 132
Helitron_like_N pfam14214
Helitron helicase-like domain at N-terminus; This family is found in Helitrons, recently ...
822-1014 3.53e-36

Helitron helicase-like domain at N-terminus; This family is found in Helitrons, recently recognized eukaryotic transposons that are predicted to amplify by a rolling-circle mechanism. In many instances a protein-coding gene is disrupted by their insertion.


:

Pssm-ID: 464105  Cd Length: 199  Bit Score: 135.87  E-value: 3.53e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839  822 RILHADGRFAQNIEYIFYAQYLSEIQQVLSNVSIALRKghgYNKSIPSEMFkDTESLRQVLNFDEG-----------YRF 890
Cdd:pfam14214    4 RLQHHDGRFARHPRFLFVAFNLFQQARAESRRLSFIRV---NQKELRAESY-TGERLRDALEEETDdpevlallgsiVIL 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839  891 LKPIRGTPAFWQGVQKDLFAMVRQLGIPTWFCSFSSADMrWTNLMSSILKHEGRNKTLEQLEWdekCELLRRNPVTAARM 970
Cdd:pfam14214   80 PSSVPGSPRYMLQLRQDAMAIVRRLGKPDLFITFTPNDL-WPEIKRELARYREWKLPGAQTRL---RRLASDRPDIVARV 155
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2073625839  971 FDFRWHCFLKEVLMSPVQPIGEIVDYFYRVEFQQRGSPHVHCLF 1014
Cdd:pfam14214  156 FHRKLELFLKDLLRFKEGVFGNVSAYVYTVEFQKRGLPHAHGLL 199
DUF6570 pfam20209
Domain of unknown function (DUF6570); This entry represents a presumed domain of unknown ...
581-710 7.60e-20

Domain of unknown function (DUF6570); This entry represents a presumed domain of unknown function that is found in a wide range of proteins that includes eukaryotic transposon protein.


:

Pssm-ID: 466360  Cd Length: 134  Bit Score: 86.62  E-value: 7.60e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839  581 KGEMPAESAVNNLELKPIPEELHCLNNLEQHLIALHIPFMKMLAL--PKGGQNGVHGPISCVAANIkHTTNVLPRT-ENE 657
Cdd:pfam20209    1 RGKLPKFSLANGLWIGEVPEELQDLTFVEELLIARVRPRVYVVKLrpKSGGQRGLRGNVIAFPQDV-GKLSVLPRPpEDL 79
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2073625839  658 GSLICVKLKR-KLTYKGHYKYQY-VDTTNIKQALCCLKKINKYYTDIIFNDDWLN 710
Cdd:pfam20209   80 DDVIAVLFIGpKKPTKEWLKKPFrVRRAKVRAALRWLKANNPLYRDIEIDEENLA 134
 
Name Accession Description Interval E-value
OTU_CeDUB-like cd22755
OTU (ovarian tumor) domain of Caenorhabditis elegans deubiquitylating enzyme with USP/UBP and ...
94-219 1.38e-56

OTU (ovarian tumor) domain of Caenorhabditis elegans deubiquitylating enzyme with USP/UBP and OTU domains, and similar proteins; This subfamily is composed of mostly uncharacterized proteins containing an OTU domain, similar to Caenorhabditis elegans deubiquitylating enzyme with USP/UBP and OTU domains. OTU domain-containing proteins function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation. They belong to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad.


Pssm-ID: 438592 [Multi-domain]  Cd Length: 132  Bit Score: 191.71  E-value: 1.38e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839   94 CKTVSILGDGNCFFRAVAQVICGTQKPHRAVRLAIVKHMELHSVQYKNLLRCQYASMEDYLSKSKMRFVGSWATELEIQA 173
Cdd:cd22755      1 CKTIKIVGDGNCFFRALSYAITGSEKYHRKIRKAIVDFLEKNPDEFRNLLRSDYESVEEYLEKSRMRYDGTWATDVEIFA 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2073625839  174 MANYLGVDIYTYHNE--KWLQYSCMHE----RTCNQGIYLQHCNENHYEVVV 219
Cdd:cd22755     81 AATLLGVDIYVYSKGgyKWLLYSPRFKlgkrNGSREAIYLKNTNGNHFEPVV 132
Helitron_like_N pfam14214
Helitron helicase-like domain at N-terminus; This family is found in Helitrons, recently ...
822-1014 3.53e-36

Helitron helicase-like domain at N-terminus; This family is found in Helitrons, recently recognized eukaryotic transposons that are predicted to amplify by a rolling-circle mechanism. In many instances a protein-coding gene is disrupted by their insertion.


Pssm-ID: 464105  Cd Length: 199  Bit Score: 135.87  E-value: 3.53e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839  822 RILHADGRFAQNIEYIFYAQYLSEIQQVLSNVSIALRKghgYNKSIPSEMFkDTESLRQVLNFDEG-----------YRF 890
Cdd:pfam14214    4 RLQHHDGRFARHPRFLFVAFNLFQQARAESRRLSFIRV---NQKELRAESY-TGERLRDALEEETDdpevlallgsiVIL 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839  891 LKPIRGTPAFWQGVQKDLFAMVRQLGIPTWFCSFSSADMrWTNLMSSILKHEGRNKTLEQLEWdekCELLRRNPVTAARM 970
Cdd:pfam14214   80 PSSVPGSPRYMLQLRQDAMAIVRRLGKPDLFITFTPNDL-WPEIKRELARYREWKLPGAQTRL---RRLASDRPDIVARV 155
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2073625839  971 FDFRWHCFLKEVLMSPVQPIGEIVDYFYRVEFQQRGSPHVHCLF 1014
Cdd:pfam14214  156 FHRKLELFLKDLLRFKEGVFGNVSAYVYTVEFQKRGLPHAHGLL 199
DUF6570 pfam20209
Domain of unknown function (DUF6570); This entry represents a presumed domain of unknown ...
581-710 7.60e-20

Domain of unknown function (DUF6570); This entry represents a presumed domain of unknown function that is found in a wide range of proteins that includes eukaryotic transposon protein.


Pssm-ID: 466360  Cd Length: 134  Bit Score: 86.62  E-value: 7.60e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839  581 KGEMPAESAVNNLELKPIPEELHCLNNLEQHLIALHIPFMKMLAL--PKGGQNGVHGPISCVAANIkHTTNVLPRT-ENE 657
Cdd:pfam20209    1 RGKLPKFSLANGLWIGEVPEELQDLTFVEELLIARVRPRVYVVKLrpKSGGQRGLRGNVIAFPQDV-GKLSVLPRPpEDL 79
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2073625839  658 GSLICVKLKR-KLTYKGHYKYQY-VDTTNIKQALCCLKKINKYYTDIIFNDDWLN 710
Cdd:pfam20209   80 DDVIAVLFIGpKKPTKEWLKKPFrVRRAKVRAALRWLKANNPLYRDIEIDEENLA 134
OTU pfam02338
OTU-like cysteine protease; This family is comprised of a group of predicted cysteine ...
101-189 2.11e-07

OTU-like cysteine protease; This family is comprised of a group of predicted cysteine proteases, homologous to the Ovarian Tumour (OTU) gene in Drosophila. Members include proteins from eukaryotes, viruses and pathogenic bacterium. The conserved cysteine and histidine, and possibly the aspartate, represent the catalytic residues in this putative group of proteases.


Pssm-ID: 426728 [Multi-domain]  Cd Length: 127  Bit Score: 50.91  E-value: 2.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839  101 GDGNCFFRAVAQVICGTQKPHRAvrlaiVKHMEL-----HSV-QYKNLLRCQYASMEDYLSKsKMRFVGSWATELEIQAM 174
Cdd:pfam02338    2 GDGNCLYRSISHQLWGVHDVLRK-----MLVQELretlaEYMrEHKEEFEPFLEDDETGDII-EIEQTGAWGGEIEIFAL 75
                           90
                   ....*....|....*
gi 2073625839  175 ANYLGVDIYTYHNEK 189
Cdd:pfam02338   76 AHILRRPIIVYKSEG 90
 
Name Accession Description Interval E-value
OTU_CeDUB-like cd22755
OTU (ovarian tumor) domain of Caenorhabditis elegans deubiquitylating enzyme with USP/UBP and ...
94-219 1.38e-56

OTU (ovarian tumor) domain of Caenorhabditis elegans deubiquitylating enzyme with USP/UBP and OTU domains, and similar proteins; This subfamily is composed of mostly uncharacterized proteins containing an OTU domain, similar to Caenorhabditis elegans deubiquitylating enzyme with USP/UBP and OTU domains. OTU domain-containing proteins function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation. They belong to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad.


Pssm-ID: 438592 [Multi-domain]  Cd Length: 132  Bit Score: 191.71  E-value: 1.38e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839   94 CKTVSILGDGNCFFRAVAQVICGTQKPHRAVRLAIVKHMELHSVQYKNLLRCQYASMEDYLSKSKMRFVGSWATELEIQA 173
Cdd:cd22755      1 CKTIKIVGDGNCFFRALSYAITGSEKYHRKIRKAIVDFLEKNPDEFRNLLRSDYESVEEYLEKSRMRYDGTWATDVEIFA 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2073625839  174 MANYLGVDIYTYHNE--KWLQYSCMHE----RTCNQGIYLQHCNENHYEVVV 219
Cdd:cd22755     81 AATLLGVDIYVYSKGgyKWLLYSPRFKlgkrNGSREAIYLKNTNGNHFEPVV 132
Helitron_like_N pfam14214
Helitron helicase-like domain at N-terminus; This family is found in Helitrons, recently ...
822-1014 3.53e-36

Helitron helicase-like domain at N-terminus; This family is found in Helitrons, recently recognized eukaryotic transposons that are predicted to amplify by a rolling-circle mechanism. In many instances a protein-coding gene is disrupted by their insertion.


Pssm-ID: 464105  Cd Length: 199  Bit Score: 135.87  E-value: 3.53e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839  822 RILHADGRFAQNIEYIFYAQYLSEIQQVLSNVSIALRKghgYNKSIPSEMFkDTESLRQVLNFDEG-----------YRF 890
Cdd:pfam14214    4 RLQHHDGRFARHPRFLFVAFNLFQQARAESRRLSFIRV---NQKELRAESY-TGERLRDALEEETDdpevlallgsiVIL 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839  891 LKPIRGTPAFWQGVQKDLFAMVRQLGIPTWFCSFSSADMrWTNLMSSILKHEGRNKTLEQLEWdekCELLRRNPVTAARM 970
Cdd:pfam14214   80 PSSVPGSPRYMLQLRQDAMAIVRRLGKPDLFITFTPNDL-WPEIKRELARYREWKLPGAQTRL---RRLASDRPDIVARV 155
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2073625839  971 FDFRWHCFLKEVLMSPVQPIGEIVDYFYRVEFQQRGSPHVHCLF 1014
Cdd:pfam14214  156 FHRKLELFLKDLLRFKEGVFGNVSAYVYTVEFQKRGLPHAHGLL 199
OTU cd22744
OTU (ovarian tumor) domain family; The OTU family of cysteine proteases use a conserved ...
95-218 1.34e-27

OTU (ovarian tumor) domain family; The OTU family of cysteine proteases use a conserved cysteine and histidine, and in most cases an aspartate, as the catalytic triad. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation.


Pssm-ID: 438581 [Multi-domain]  Cd Length: 128  Bit Score: 108.68  E-value: 1.34e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839   95 KTVSILGDGNCFFRAVAQVICGTQKPHRAVRLAIVKHMELHSVQYKNLL---RCQYASMEDYLskSKMRFVGSWATELEI 171
Cdd:cd22744      1 RVVDVPGDGNCLFRALAHALYGDQESHRELRQEVVDYLRENPDLYEPAEladEDDGEDFDEYL--QRMRKPGTWGGELEL 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2073625839  172 QAMANYLGVDIYTYH-NEKWLQYSCMHERTCNQG--IYLQHCNENHYEVV 218
Cdd:cd22744     79 QALANALNVPIVVYSeDGGFLPVSVFGPGPGPSGrpIHLLYTGGNHYDAL 128
DUF6570 pfam20209
Domain of unknown function (DUF6570); This entry represents a presumed domain of unknown ...
581-710 7.60e-20

Domain of unknown function (DUF6570); This entry represents a presumed domain of unknown function that is found in a wide range of proteins that includes eukaryotic transposon protein.


Pssm-ID: 466360  Cd Length: 134  Bit Score: 86.62  E-value: 7.60e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839  581 KGEMPAESAVNNLELKPIPEELHCLNNLEQHLIALHIPFMKMLAL--PKGGQNGVHGPISCVAANIkHTTNVLPRT-ENE 657
Cdd:pfam20209    1 RGKLPKFSLANGLWIGEVPEELQDLTFVEELLIARVRPRVYVVKLrpKSGGQRGLRGNVIAFPQDV-GKLSVLPRPpEDL 79
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2073625839  658 GSLICVKLKR-KLTYKGHYKYQY-VDTTNIKQALCCLKKINKYYTDIIFNDDWLN 710
Cdd:pfam20209   80 DDVIAVLFIGpKKPTKEWLKKPFrVRRAKVRAALRWLKANNPLYRDIEIDEENLA 134
OTU_plant_OTU7-like cd22771
OTU (ovarian tumor) domain of Arabidopsis thaliana deubiquitinating enzyme OTU7 and similar ...
94-215 6.96e-18

OTU (ovarian tumor) domain of Arabidopsis thaliana deubiquitinating enzyme OTU7 and similar proteins; Arabidopsis thaliana deubiquitinating enzyme OTU7, also called OTU domain-containing protein 7, is a deubiquitinase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) that shows a preference for 'Lys-63' over 'Lys-48' over 'Met-1'-linked ubiquitin (UB) tetramers as substrates. DUBs catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation. OTU7 belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad.


Pssm-ID: 438608 [Multi-domain]  Cd Length: 124  Bit Score: 80.67  E-value: 6.96e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839   94 CKTVSILGDGNCFFRAVAQVICGTQKPHRAVRLAIVKHMELHSVQYKNLLrCQYASMEDYLskSKMRFVGSWATELEIQA 173
Cdd:cd22771      2 LRIRDVEGDGNCLFRALADQLYGDEERHAELRKKVVDYMEAHEEDFEPFF-EDDETFEDYV--SRMREDGTWGGNLELQA 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2073625839  174 MANYLGVDI--YTYHNEKW-LQYSCMHERTCnqgIYLQHCNENHY 215
Cdd:cd22771     79 ASLVYRVNIvvHQLGQPRWeIENFPDKGART---IHLSYHDGEHY 120
OTU_232R-like cd22758
OTU (ovarian tumor) domain of Invertebrate iridescent virus putative ubiquitin thioesterase ...
101-215 2.29e-17

OTU (ovarian tumor) domain of Invertebrate iridescent virus putative ubiquitin thioesterase 232R and similar proteins; This subfamily contains putative ubiquitin thioesterases 232R from Invertebrate iridescent virus and L96 from Tipula iridescent virus (TIV), Dictyostelium discoideum OTU domain-containing protein DDB_G0284757, and similar proteins. L96 may be involved in TIV genomic DNA packaging in a manner related to the Gag polyproteins of the mammalian viruses. Proteins in this subfamily contain an OTU domain. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation. They belong to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad.


Pssm-ID: 438595 [Multi-domain]  Cd Length: 135  Bit Score: 79.62  E-value: 2.29e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839  101 GDGNCFFRAVAQVICGTQKPHRA--VRLAIVKHMELHSVQYKN---LLRCQYASMEDYLskSKMRFVGSWATELEIQAMA 175
Cdd:cd22758     13 GDGNCFFHAVSDQLYGNGIEHSHkeLRQQAVNYLRENPELYDGfflSEFDEEESWEEYL--NRMSKDGTWGDHIILQAAA 90
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2073625839  176 NYLGVDIYTYHNEKWLQYSCMHERTCNQG--IYLQHCNENHY 215
Cdd:cd22758     91 NLFNVRIVIISSDGSDETTIIEPGNSKNGrtIYLGHIGENHY 132
OTU_OTUD3-like cd22756
OTU (ovarian tumor) domain of OTU domain-containing protein 3 and similar proteins; This ...
95-218 3.83e-16

OTU (ovarian tumor) domain of OTU domain-containing protein 3 and similar proteins; This subfamily includes bilaterial OTU domain-containing protein 3 (OTUD3), Arabidopsis thaliana deubiquitinating enzyme OTU7, also called OTU domain-containing protein 7, and similar proteins. OTUD3 is a deubiquitinase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. It is an acetylation-dependent deubiquitinase that restricts innate antiviral immune signaling. It directly hydrolyzes lysine 63 (Lys63)-linked polyubiquitination of MAVS (mitochondrial antiviral-signaling protein) and shuts off innate antiviral immune response. OTUD3 can elicit tumor-suppressing or tumor-promoting activities in a cell- and tissue-dependent manner. It is a DUB for PTEN (phosphatase and tension homologue deleted on chromosome 10); the OTUD3-PTEN signaling axis plays a critical role in suppression of breast tumorigenesis. OTUD3 is also a DUB for glucose-regulated protein GRP78, stabilizing it and promoting lung tumorigenesis. OTU7 is a DUB that shows a preference for 'Lys-63' over 'Lys-48' over 'Met-1'-linked ubiquitin (UB) tetramers as substrates. This subfamily belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad.


Pssm-ID: 438593 [Multi-domain]  Cd Length: 131  Bit Score: 76.06  E-value: 3.83e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839   95 KTVSILGDGNCFFRAVAQVICGTQKPHRAVRLAIVKHMELHSVQYKNLLR-----CQYASMEDYLskSKMRFVGSWATEL 169
Cdd:cd22756      1 YAKDITGDGNCLFRALSDQLYGDPDRHLEIRAEVVEYMRANPDDFKPFSEaatfaEDDEAFEDYL--ARMAKDGTYGDNL 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2073625839  170 EIQAMANYLGVDIYTY-HNEKWlQYSCMHERTCNQG---IYLQHCNENHYEVV 218
Cdd:cd22756     79 EIVAFARAYNVDVKVYqPDPVY-VISAPEDGSPGPArrvLHIAYHNWEHYSSV 130
OTU_P87_VP80-like cd22757
OTU (ovarian tumor) domain of nucleopolyhedrovirus P87/VP80 protein and similar proteins; The ...
97-189 8.53e-14

OTU (ovarian tumor) domain of nucleopolyhedrovirus P87/VP80 protein and similar proteins; The VP80 protein is a capsid-associated structural protein that was first identified as P87 in Orgyia pseudotsugata multicapsid nuclear polyhedrosis virus (OpMNPV); its homologs are found only in NPV genomes. The Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) VP80 protein is essential for the formation of both budded virus (BV) and occlusion-derived virus (ODV). It has also been shown to interact with the virus-triggered, nuclear F-actin cytoskeleton. P87/VP80 contains an N-terminal OTU domain. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation. They belong to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad.


Pssm-ID: 438594 [Multi-domain]  Cd Length: 128  Bit Score: 69.15  E-value: 8.53e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839   97 VSILGDGNCFFRAVAQVICGTQKPHRAVRLAIVKHMELHSVQYKNLLRCQ----YASMEDYlsKSKMRFVGSWATELEIQ 172
Cdd:cd22757      4 IPIPGDGACLFRALSYLLYGTQSRHLEVRKEVVDYVVNNWDEFSIYTHDSegnnYKSAEEY--RADMSKPGTYGTLCELV 81
                           90
                   ....*....|....*..
gi 2073625839  173 AMANYLGVDIYTYHNEK 189
Cdd:cd22757     82 AAAELYPFHFEVYRNGK 98
OTU_ALG13-like cd22753
OTU (ovarian tumor) domain of bifunctional UDP-N-acetylglucosamine transferase and ...
102-219 1.38e-13

OTU (ovarian tumor) domain of bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 and similar proteins; Bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 is alco called asparagine-linked glycosylation 13 homolog, glycosyltransferase 28 domain-containing protein 1 (GLT28D1), or UDP-N-acetylglucosamine transferase subunit ALG13 homolog. It displays both glycosyltransferase (EC 2.4.1.141) and deubiquitinase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) activities. With ALG14, it forms a UDP-N-acetylglucosamine transferase that catalyzes the second step of eukaryotic N-linked glycosylation in the endoplasmic reticulum. ALG13 variants cause a form of early infantile epileptic encephalopathy known as EIEE36 refractory seizures, neurodevelopmental impairment, and poor prognosis; given the essential role of ALG13 in glycosylation, it is also considered a congenital disorder of glycosylation (CDG). This subfamily also contains OTU domain-containing protein 4 (OTUD4), also called HIV-1-induced protein HIN-1, a DUB that specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein upon phosphorylation, triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators. This subfamily belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad.


Pssm-ID: 438590 [Multi-domain]  Cd Length: 130  Bit Score: 68.72  E-value: 1.38e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839  102 DGNCFFRAVAQVICGTQKPHRAVRLAIVKHMELHSVQYKNLLRcqyASMEDYLskSKMRFVGSWATELEIQAMANYLGVD 181
Cdd:cd22753     18 DGSCLFRAVSEQLFFTQSYHQQVRQACVEYLEKNREEFEKFSE---ISFDDYL--ERLSDPKEWGGLLELEALSLLYKVD 92
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2073625839  182 IYTYHNEKwlQYSCMH-ERTCNQGIYLQHCNENHYEVVV 219
Cdd:cd22753     93 FIVYSIPD--QPPSNItNNGYPKKIMLCYSGGNHYDSVY 129
OTU_plant_OTU9-like cd22751
OTU (ovarian tumor) domain of plant deubiquitinating enzyme OTU9 and similar proteins; This ...
99-215 1.56e-13

OTU (ovarian tumor) domain of plant deubiquitinating enzyme OTU9 and similar proteins; This subfamily contains Arabidopsis thaliana deubiquitinating enzymes OTU8, OTU9, OTU10, OTU11, and OTU12, and similar proteins from plants and other eukaryotes. OTU8-OTU12 are deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation. They belong to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad.


Pssm-ID: 438588 [Multi-domain]  Cd Length: 134  Bit Score: 68.72  E-value: 1.56e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839   99 ILGDGNCFFRAVAQVICGTQKPHRAVRLAIVKHMELHSVQYknllRCQYASME--DYLskSKMRFVGSWATELEIQAMAN 176
Cdd:cd22751     15 VEGDGNCQFRALSDQLFGTQDHHAEVRELVVKQLRAHPELY----YEFYVPEEydEYL--KKMSKDGEWGDELTLQAAAD 88
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2073625839  177 YLGVDIY-------TYHNEKWLQYSCMHERTcnqgIYLQHCNENHY 215
Cdd:cd22751     89 AFGVKIHvitsfedNWFLEIEPRGLVRSKRV----LFLSYWAEVHY 130
OTU_VRTN cd22791
OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU ...
97-186 1.02e-09

OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU domain-containing protein that is required for the development of thoracic vertebrae in mammals. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation. Vertnin and some subfamily members do not possess the conserved catalytic residues and may not have DUB activity. VRTN gene is associated with variations in vertebral number.


Pssm-ID: 438612  Cd Length: 137  Bit Score: 57.61  E-value: 1.02e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839   97 VSILGDGNCFFRAVAQVICGTQKPHRAVRLAIVKHMELHSVQYKNLLRcqyasmEDYLsksKMRFVGSWATELEIQAMAN 176
Cdd:cd22791      4 LRVTGDGNCLFRAASLLLFGDESLHLELRLRTVLELVLNSEFYEAIYE------AEIK---ATCKPGSYSGIWHIYALSS 74
                           90
                   ....*....|
gi 2073625839  177 YLGVDIYTYH 186
Cdd:cd22791     75 VLQRPIFSVY 84
OTU_OTUD1 cd22747
OTU (ovarian tumor) domain of OTU domain-containing protein 1 and similar proteins; OTU ...
99-183 2.74e-09

OTU (ovarian tumor) domain of OTU domain-containing protein 1 and similar proteins; OTU domain-containing protein 1 (OTUD1), also called DUBA-7 in humans, is a deubiquitinating enzyme/ubiquitinyl hydrolase (EC 3.4.19.12) that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin; this specificity is facilitated by the C-terminal Ub-interacting motif (UIM) of OTUD1. It interacts and promotes the deubiquitination of myeloid cell leukemia 1 (MCL1), a pro-survival Bcl-2 family protein that plays important roles in cell survival, proliferation, differentiation and tumorigenesis. OTUD1 also deubiquitinates IFN regulatory factor 3 (IRF3) and attenuates its function; IRF3 is critical for the transcription of type I IFNs in defensing virus and promoting inflammatory responses. Loss-of-function mutations of OTUD1 associated with multiple autoimmune diseases including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), ulcerative colitis (UC) and Hashimoto's thyroiditis (HT). OTUD1 belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad.


Pssm-ID: 438584 [Multi-domain]  Cd Length: 149  Bit Score: 57.13  E-value: 2.74e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839   99 ILGDGNCFFRAVAQVICGTQKPHRAVRLAIVKHMELHSVQYKNLLRCqyaSMEDYLSKSKMRfvGSWATELEIQAMANYL 178
Cdd:cd22747     26 IIPDGNCLYRAVSKAVYGDQALHRELREQTVHYIADHLDEFNPIIEG---DVGEFLIKAAQD--GAWAGYPELLAMGQML 100

                   ....*
gi 2073625839  179 GVDIY 183
Cdd:cd22747    101 NVNIR 105
OTU_OTUD5-like cd22752
OTU (ovarian tumor) domain of OTU domain-containing protein 5 and similar proteins; OTU ...
101-219 3.06e-09

OTU (ovarian tumor) domain of OTU domain-containing protein 5 and similar proteins; OTU domain-containing protein 5 (OTUD5), also called deubiquitinating enzyme A (DUBA), is a phosphorylation-dependent deubiquitinase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) that can hydrolyze 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, and may function as negative regulator of the innate immune system. It limits type I interferon production in macrophages and suppresses interleukin-17A production in T cells. OTUD5 also functions in an apoptotic signaling cascade by mediating the sequential activation of PDCD5 (programmed cell death 5) and p53 in response to genotoxic stress. In Drosophila, OTUD5/DUBA is essential for spermatogenesis. This subfamily also includes Arabidopsis thaliana OTU domain-containing protein 6, also called deubiquitinating enzyme OTU6 or otubain-like deubiquitinase 1 (OTLD1), which binds chromatin and has enzymatic histone deubiquitinase activity specific for the H2B histone. This subfamily belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad. It also includes plant OTU6.


Pssm-ID: 438589 [Multi-domain]  Cd Length: 124  Bit Score: 56.02  E-value: 3.06e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839  101 GDGNCFFRAVAQVICGTQKPHRAVRLAIVKHMELHSVQYKNLLrcqYASMEDYLskSKMRFVGSWATELEIQAMANYLG- 179
Cdd:cd22752      9 EDGNCLFRAVADQVYGDQEMHDVVRKHCMDYMEKNRDYFSQFV---TEDFEEYI--NRKRQDGVWGNHIEIQAMSELYNr 83
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 2073625839  180 -VDIYTYHNEKWLQYSCMHERTcNQGIYLQHCNENHYEVVV 219
Cdd:cd22752     84 pIEVYAYSTEPINTFHEASSSD-NEPIRLSYHGNSHYNSIV 123
OTU_OTUD4 cd22794
OTU (ovarian tumor) domain of OTU domain-containing protein 4 and similar proteins; OTU ...
99-218 3.75e-09

OTU (ovarian tumor) domain of OTU domain-containing protein 4 and similar proteins; OTU domain-containing protein 4 (OTUD4), also called HIV-1-induced protein HIN-1, is a deubiquitinase that specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein upon phosphorylation, triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators. OTUD4 belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad.


Pssm-ID: 438615 [Multi-domain]  Cd Length: 130  Bit Score: 55.84  E-value: 3.75e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839   99 ILGDGNCFFRAVAQVICGTQKPHRAVRLAIVKHMELHSVQYKNLLRcqyASMEDYLskSKMRFVGSWATELEIQAMANYL 178
Cdd:cd22794     15 IAKDGSCLFRAVAEQVFHTQSRHLEVRKACVDYLRRNREKFEAFIE---GPFEQYL--KNLENPKEWAGQVEISALSLMY 89
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2073625839  179 GVDIYTYHnEKWLQYSCMHERTCNQGIYLQHCNENHYEVV 218
Cdd:cd22794     90 KRDFIIYQ-EPGKPPSNVTENGFPDKILLCFSNGNHYDSV 128
OTU_plant_OTU6-like cd22796
OTU (ovarian tumor) domain of deubiquitinating enzyme OTU6 from plants and similar proteins; ...
95-219 8.62e-08

OTU (ovarian tumor) domain of deubiquitinating enzyme OTU6 from plants and similar proteins; Deubiquitinating enzyme OTU6, also called OTU domain-containing protein 6 or otubain-like deubiquitinase 1 (OTLD1), is a deubiquitinase (DUB) or ubiquitin thiolesterase (EC 3.4.19.12) that catalyzes the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. OTU6 binds chromatin and has enzymatic histone deubiquitinase activity specific for the H2B histone. OTU6 belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad.


Pssm-ID: 438617 [Multi-domain]  Cd Length: 128  Bit Score: 52.04  E-value: 8.62e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839   95 KTVSILGDGNCFFRAVAQVICGTQKPHRAVRLAIVKHMELHSVQYKNLLRcqyASMEDYLSKSKMRFVgsWATELEIQAM 174
Cdd:cd22796      6 EIRRMDGDGNCLFRAVADQVYGDQEMHDEVREMCMDYMEKERDHFSQFVT---EDFTQYVKRKRRDRV--FGNNLEIQAM 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 2073625839  175 ANYLG--VDIYTYHNEKWLQYSCMHERTCNQGIYLQHCNENHYEVVV 219
Cdd:cd22796     81 SEIYNrpIEVYSYSNGEPINIFHGSYEGDDPPIRLSYHDGNHYNSII 127
OTU pfam02338
OTU-like cysteine protease; This family is comprised of a group of predicted cysteine ...
101-189 2.11e-07

OTU-like cysteine protease; This family is comprised of a group of predicted cysteine proteases, homologous to the Ovarian Tumour (OTU) gene in Drosophila. Members include proteins from eukaryotes, viruses and pathogenic bacterium. The conserved cysteine and histidine, and possibly the aspartate, represent the catalytic residues in this putative group of proteases.


Pssm-ID: 426728 [Multi-domain]  Cd Length: 127  Bit Score: 50.91  E-value: 2.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839  101 GDGNCFFRAVAQVICGTQKPHRAvrlaiVKHMEL-----HSV-QYKNLLRCQYASMEDYLSKsKMRFVGSWATELEIQAM 174
Cdd:pfam02338    2 GDGNCLYRSISHQLWGVHDVLRK-----MLVQELretlaEYMrEHKEEFEPFLEDDETGDII-EIEQTGAWGGEIEIFAL 75
                           90
                   ....*....|....*
gi 2073625839  175 ANYLGVDIYTYHNEK 189
Cdd:pfam02338   76 AHILRRPIIVYKSEG 90
OTU_OTUD6-like cd22748
OTU (ovarian tumor) domain of OTU domain-containing proteins 6A, 6B, and similar proteins; ...
98-186 6.83e-06

OTU (ovarian tumor) domain of OTU domain-containing proteins 6A, 6B, and similar proteins; This subfamily is composed of mammalian OTU domain-containing protein 6A (OTUD6A, also called DUBA-2, vertebrate OTU domain-containing protein 6B (OTUD6B, also called DUBA-5), fungal OTU domain-containing protein 2 (OTU2), and similar proteins. OTUD6A, OTUD6B, and Schizosaccharomyces pombe OTU2 are deubiquitinating enzymes/ubiquitinyl hydrolases (EC 3.4.19.12). OTUD6A hydrolyzes 'Lys-27'-, 'Lys-29'-, and 'Lys-33'-linked polyubiquitin chains, and may also be able to hydrolyze 'Lys-11'-linked ubiquitin chains. It deubiquitylates and stabilizes dynamin-related protein 1 (Drp1), a cytosolic protein responsible for mitochondrial fission and is essential in the initiation and development of several human diseases including cancer, thereby facilitating tumorigenesis. OTUD6B is a functional deubiquitinase in in vitro enzyme assays. It may play a role in the ubiquitin-dependent regulation of protein synthesis downstream of mTORC1, and may modify the ubiquitination of the protein synthesis initiation complex to repress translation. Biallelic variants in OTUD6B cause an intellectual disability syndrome that is associated with seizures and dysmorphic features. This subfamily belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad.


Pssm-ID: 438585 [Multi-domain]  Cd Length: 144  Bit Score: 46.79  E-value: 6.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839   98 SILGDGNCFFRAVA---QVICGTQKP--HRAVRLAIVKHMELHSVQYKNLLRCQYASM------EDYLskSKMRFVGSWA 166
Cdd:cd22748     10 EIPPDGHCLYRAIAdqlKLRGGSEEPysYKELRKLAADYMRAHRDDFLPFLTNDDGDLmteeefEEYC--DKIENTAEWG 87
                           90       100
                   ....*....|....*....|
gi 2073625839  167 TELEIQAMANYLGVDIYTYH 186
Cdd:cd22748     88 GQLELRALSKALKRPIHVYQ 107
OTU_RNAP_L_virus cd21880
OTU (ovarian tumor) domain of viral RNA-directed RNA polymerase L; RNA-directed RNA polymerase ...
101-186 2.74e-05

OTU (ovarian tumor) domain of viral RNA-directed RNA polymerase L; RNA-directed RNA polymerase L is also called protein L, large structural protein, replicase, transcriptase, or ubiquitin thioesterase. It displays RNA-directed RNA polymerase (EC 2.7.7.48), deubiquitinase (DUB)/ubiquitin thiolesterase (EC 3.4.19.12), and deISGylating activities. It is a viral homolog of ovarian tumor protease (vOTU) that has been implicated in the downregulation of type I interferon immune response by removing post-translational modifying proteins ubiquitin (Ub) and the Ub-like interferon-simulated gene 15 (ISG15) from host cellular proteins. The attachment of Ub and ISG15 to cellular proteins mediates important innate antiviral responses, and their removal inhibits these antiviral pathways. This subfamily belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad.


Pssm-ID: 438580  Cd Length: 148  Bit Score: 45.28  E-value: 2.74e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839  101 GDGNCFFRAVAQVICGTQKPHRAVRLAIVKHMELHSVQYKNLLRCqYASMEDYLSKSKMRfvGSWATELEIQAMANYLGV 180
Cdd:cd21880     29 GDGNCFFRSIAELLFDTEDEWRLVKNTIESYARANWDECPEARLY-YLSLEEYLRDAMKD--GYWGGSLEAEILSKALGI 105

                   ....*.
gi 2073625839  181 DIYTYH 186
Cdd:cd21880    106 TIIIWV 111
OTU_fungi_OTU2-like cd22762
OTU (ovarian tumor) domain of fungal OTU domain-containing protein 2 and similar proteins; ...
99-182 1.50e-04

OTU (ovarian tumor) domain of fungal OTU domain-containing protein 2 and similar proteins; This subfamily includes Schizosaccharomyces pombe and Saccharomyces cerevisiae OTU domain-containing protein 2 (OTU2) and similar proteins. S. pombe OTU2 is a ubiquitin thioesterase/hydrolase (EC 3.4.19.12) that can remove conjugated ubiquitin from protein substrates and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Fungal OTU2 bbelongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad.


Pssm-ID: 438599 [Multi-domain]  Cd Length: 142  Bit Score: 42.98  E-value: 1.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839   99 ILGDGNCFFRAVA----QVICGTQKPHRAVRLAIVKHMELHSVQYKNLLRCQYASMED---YLSKskMRFVGSWATELEI 171
Cdd:cd22762     12 IKPDGHCLFAAIAdqlqLRGSEINLDYKELRKLAAEYIRKHPDDFEPFLFEETDELEDideYCKK--IENTAEWGGELEL 89
                           90
                   ....*....|.
gi 2073625839  172 QAMANYLGVDI 182
Cdd:cd22762     90 LALAKAFGVPI 100
OTU_plant_OTU3_4-like cd22746
OTU (ovarian tumor) domain of deubiquitinating enzymes OTU3 and OTU4 from plants, and similar ...
95-219 2.34e-03

OTU (ovarian tumor) domain of deubiquitinating enzymes OTU3 and OTU4 from plants, and similar proteins; Deubiquitinating enzyme OTU3 (also called OTU domain-containing protein 3) and deubiquitinating enzyme OTU4 (also called OTU domain-containing protein 4) are deubiquitinases (DUBs) or ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. OTU3 and OTU4 may play important regulatory roles at the level of protein turnover by preventing degradation. They belong to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad.


Pssm-ID: 438583 [Multi-domain]  Cd Length: 141  Bit Score: 39.56  E-value: 2.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839   95 KTVSILGDGNCFFRAVAQVIC----GTQKPHR-------AVRLAIVKHMELHSVQYKNLLRCQYASMEDYLskSKMRFVG 163
Cdd:cd22746      3 RVVPVKGDGRCLFRAVARGLAlatgGRPLSERreradadALRKAVVEEIRKRRDELFEGSLVIEGDFDAYC--QRMSHPD 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2073625839  164 SWATELEIQAMANYLGVDIYTYH-NEKWLQYSCM----HERTCNQGIYLQHCNENHYEVVV 219
Cdd:cd22746     81 TWGGEPELLMLADVLQRPIAVYLpTPGKGGLRKIqeygEEYLGGEPIRLLYNGGNHYDLLL 141
OTU_RDRP-like cd22792
OTU (ovarian tumor) domain of the potexviruses/carlaviruses RNA replication protein family; ...
95-219 4.42e-03

OTU (ovarian tumor) domain of the potexviruses/carlaviruses RNA replication protein family; RNA replication polyprotein (RDRP) is a viral homolog of ovarian tumor protease (vOTU), which displays RNA helicase (EC 3.6.4.13), RNA-directed RNA polymerase (EC 2.7.7.48), viral methyltransferase, Fe(2+) 2-oxoglutarate dioxygenase and protease activities. The central part of this protein possibly functions as an ATP-binding helicase. It is an RNA-directed RNA polymerase involved in viral RNA replication. It also acts as a thiol protease that cleaves the polyprotein. This subfamily belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad.


Pssm-ID: 438613 [Multi-domain]  Cd Length: 108  Bit Score: 37.97  E-value: 4.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073625839   95 KTVSILGDGNCFFRAVAqVICGTQkpHRAVRLAIVKHMELHSVQYKNLLRCqyasMEDylskskmrfvGSWATELEIQAM 174
Cdd:cd22792      1 KVVPVPGDGNCFWHSLG-HFLGLS--ALELKKLLRDSLFDDPELDEELDEQ----LEP----------GVYAEDEAIAAA 63
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2073625839  175 ANYLGVDIyTYHNEkwlQYSCMHERTCN---QGIYLQHCNEnHYEVVV 219
Cdd:cd22792     64 AKLFGVNI-CVHDP---DEGVLYTFTPNessKSIHLLLENE-HFEPLV 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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