Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2074012041  96 SVVKSSFKPGDVIHYVlDRRRTLNISQDLHSLLPEVSPMKNRRFKTCAVVGNSGILLKSGCGKEIDSHDFVIR 168
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIR 72

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074012041  76 SLVMEIRKNILQFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISQDLHSLLPEVSPMKNRRFKTCAVVGNSGILLKSG 155
Cdd:cd23969     1 TEVLRMRKWILKFFDPEKDISVLKSQVKPGDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSG 80

                          90
                  ....*....|...
gi 2074012041 156 CGKEIDSHDFVIR 168
Cdd:cd23969    81 CGQEIDSHDFVIR 93

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074012041  78 VMEIRKNILQFLDAERDVsVVKSSFKPGDVIHYVLDRRRTLNISQDLHSLLPEVSPMKNRRFKTCAVVGNSGILLKSGCG 157
Cdd:cd23963     3 LDKFRKELERLLNTRKLF-LTQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCG 81

                          90
                  ....*....|.
gi 2074012041 158 KEIDSHDFVIR 168
Cdd:cd23963    82 KEIDSHDFVIR 92

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074012041  74 NSSLVMEIRKNILQFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLN-ISQDLHSLLPEVSPMKNRRFKTCAVVGNSGILL 152
Cdd:cd23970     2 NKTALLHQRKEIRQYFDVIKNISLTKKDVRIGQLMHFDYSSHKYVFsISPNLRSLLPEVSPFQNKHYNTCAVVGNSGILT 81

                          90
                  ....*....|....*.
gi 2074012041 153 KSGCGKEIDSHDFVIR 168
Cdd:cd23970    82 NSQCGNEIDKSDFVFR 97

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074012041  82 RKNILQFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISQDLHSLLPEVSPMKnRRFKTCAVVGNSGILLKSGCGKEID 161
Cdd:cd23989     7 RKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQ-LPLKKCSVVGNGGILKNSGCGQQID 85

                  ....*..
gi 2074012041 162 SHDFVIR 168
Cdd:cd23989    86 RADFVMR 92

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2074012041 105 GDVIHYVLDRRRTLNISQDLHSLLPEVSPMKNRRFKTCAVVGNSGILLKSGCGKEIDSHDFVIR 168
Cdd:cd23990    30 GTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKCGREIDSADFVFR 93

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2074012041 122 QDLHSLLPEVSPMKNR---RFKTCAVVGNSGILLKSGCGKEIDSHDFVIR 168
Cdd:cd23966    57 EKLFQVVPGENPYRTRdpnRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIR 106

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2074012041 124 LHSLLPEVSPMKNRRFKTCAVVGNSGILLKSGCGKEIDSHDFVIR 168
Cdd:cd23973    68 KEQQLLALSPPGGDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFR 112

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2074012041 122 QDLHSLLP-EVSPMKNRRF---KTCAVVGNSGILLKSGCGKEIDSHDFVIREEK 171
Cdd:cd23980    60 RELFQVVPgNVDPLLEKRLvscRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNK 113

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).

                          10        20        30
                  ....*....|....*....|....*....|..
gi 2074012041 137 RRFKTCAVVGNSGILLKSGCGKEIDSHDFVIR 168
Cdd:cd23985    43 GPLGRCAVVSSAGSLKSSGLGREIDSHDAVLR 74

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2074012041 113 DRRRTLNISQDLHSLLPEVSPMKNRRFKTCAVVGNSGILLKSGCGKEIDSHDFVIR 168
Cdd:cd23974    58 DALNLLNSSANGQMFDWWDRPNGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFR 113

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2074012041 116 RTLNISQDLHSLLPEVSPMKNRRfktCAVVGNSGILLKSGCGKEIDSHDFVIR 168
Cdd:cd23972    62 SLLNDSANAKLFFPRDTPGKCIR---CAVVGNGGILNGSRQGRAIDAHDYVFR 111

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).

                          10        20
                  ....*....|....*....|....*....
gi 2074012041 140 KTCAVVGNSGILLKSGCGKEIDSHDFVIR 168
Cdd:cd23982     3 RRCVVVGNGHNLKNSSLGDVIDSYDVVIR 31

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).

                          10        20
                  ....*....|....*....|....*....
gi 2074012041 140 KTCAVVGNSGILLKSGCGKEIDSHDFVIR 168
Cdd:cd23977     2 RRCAVVSSSGQMLGSGLGPEIDQQECVLR 30

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2074012041 140 KTCAVVGNSGILLKSGCGKEIDSHDFVIR--EEKRKSTHKEVSS 181
Cdd:cd23981     3 RRCIIVGNGGVLANKSLGSKIDDYDVVVRlnSAPVKGFEKDVGS 46