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Conserved domains on  [gi|2080336960|ref|XP_042842256|]
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forkhead box protein P4 isoform X2 [Panthera tigris]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FH_FOXP4 cd20067
Forkhead (FH) domain found in Forkhead box protein P4 (FOXP4) and similar proteins; FOXP4, ...
468-571 2.68e-58

Forkhead (FH) domain found in Forkhead box protein P4 (FOXP4) and similar proteins; FOXP4, also called Forkhead-related protein-like A, is a transcriptional repressor that represses lung-specific expression. It is not required for T cell development, but is necessary for normal T cell cytokine recall responses to antigen following pathogenic infection. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


:

Pssm-ID: 410841 [Multi-domain]  Cd Length: 87  Bit Score: 191.49  E-value: 2.68e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20067     1 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATW-----------------KNAVRHNLSLHKCFVRVE 63
                          90       100
                  ....*....|....*....|....
gi 2080336960 548 NVKGAVWTVDEREYQKRRPPKMTG 571
Cdd:cd20067    64 NVKGAVWTVDELEYQKRRPPKMTG 87
FOXP-CC pfam16159
FOXP coiled-coil domain; This domain, approximately 60-70 residues in length, is mainly found ...
304-371 6.98e-44

FOXP coiled-coil domain; This domain, approximately 60-70 residues in length, is mainly found in Forkhead box proteins in various Mammalia species. It is a coiled-coil domain, which modulates the dimeric associations of FOXP transcription factors. Several key disease mutations, for instance those found in the IPEX syndrome are located in this domain


:

Pssm-ID: 465036  Cd Length: 68  Bit Score: 151.68  E-value: 6.98e-44
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2080336960 304 LYGHGECKWPGCETLCEDLGQFIKHLNTEHALDDRSTAQCRVQMQVVQQLEIQLAKESERLQAMMAHL 371
Cdd:pfam16159   1 LFGHGVCRWPGCETVCEDFGSFLKHLNSEHALDDRSTAQCRVQMQVVQQLEIQLTKEKERLQAMMAHL 68
 
Name Accession Description Interval E-value
FH_FOXP4 cd20067
Forkhead (FH) domain found in Forkhead box protein P4 (FOXP4) and similar proteins; FOXP4, ...
468-571 2.68e-58

Forkhead (FH) domain found in Forkhead box protein P4 (FOXP4) and similar proteins; FOXP4, also called Forkhead-related protein-like A, is a transcriptional repressor that represses lung-specific expression. It is not required for T cell development, but is necessary for normal T cell cytokine recall responses to antigen following pathogenic infection. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410841 [Multi-domain]  Cd Length: 87  Bit Score: 191.49  E-value: 2.68e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20067     1 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATW-----------------KNAVRHNLSLHKCFVRVE 63
                          90       100
                  ....*....|....*....|....
gi 2080336960 548 NVKGAVWTVDEREYQKRRPPKMTG 571
Cdd:cd20067    64 NVKGAVWTVDELEYQKRRPPKMTG 87
FOXP-CC pfam16159
FOXP coiled-coil domain; This domain, approximately 60-70 residues in length, is mainly found ...
304-371 6.98e-44

FOXP coiled-coil domain; This domain, approximately 60-70 residues in length, is mainly found in Forkhead box proteins in various Mammalia species. It is a coiled-coil domain, which modulates the dimeric associations of FOXP transcription factors. Several key disease mutations, for instance those found in the IPEX syndrome are located in this domain


Pssm-ID: 465036  Cd Length: 68  Bit Score: 151.68  E-value: 6.98e-44
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2080336960 304 LYGHGECKWPGCETLCEDLGQFIKHLNTEHALDDRSTAQCRVQMQVVQQLEIQLAKESERLQAMMAHL 371
Cdd:pfam16159   1 LFGHGVCRWPGCETVCEDFGSFLKHLNSEHALDDRSTAQCRVQMQVVQQLEIQLTKEKERLQAMMAHL 68
Forkhead pfam00250
Forkhead domain;
468-558 4.18e-32

Forkhead domain;


Pssm-ID: 459732  Cd Length: 86  Bit Score: 119.11  E-value: 4.18e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:pfam00250   1 KPPYSYAALIAMAILSSPEKKLTLSEIYEWISENFPYYRTADKGW-----------------QNSIRHNLSLNKCFVKVP 63
                          90
                  ....*....|....*.
gi 2080336960 548 NV-----KGAVWTVDE 558
Cdd:pfam00250  64 RPkdepgKGSYWTIDP 79
FH smart00339
FORKHEAD; FORKHEAD, also known as a "winged helix"
468-557 2.15e-31

FORKHEAD; FORKHEAD, also known as a "winged helix"


Pssm-ID: 214627 [Multi-domain]  Cd Length: 89  Bit Score: 117.34  E-value: 2.15e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960  468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:smart00339   1 KPPYSYIALIAMAILSSPDKRLTLSEIYKWIEDNFPYYRENRAGW-----------------QNSIRHNLSLNDCFVKVP 63
                           90
                   ....*....|....*
gi 2080336960  548 N-----VKGAVWTVD 557
Cdd:smart00339  64 RegdrpGKGSYWTLD 78
COG5025 COG5025
Transcription factor of the Forkhead/HNF3 family [Transcription];
365-578 9.31e-12

Transcription factor of the Forkhead/HNF3 family [Transcription];


Pssm-ID: 227358 [Multi-domain]  Cd Length: 610  Bit Score: 68.30  E-value: 9.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 365 QAMMAHLHMRPSEPKPFSQPLNPVPGSSSFSKVTVSAADSFPDGLVHP--PTSAAAPVTPLRPPGLSSASLHSGGPARRR 442
Cdd:COG5025   240 NLDVSLGHHISQPSTHTPVLDNHSSGEENISRINNSSQIDSPTPNYRMssIDSSVNPSRLANNKDEGRKGSKSSPVPKDA 319
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 443 SSDKFCSPISSELAQNhefyknadVRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtl 522
Cdd:COG5025   320 APPSTLSDLSADVNRT--------SKPAFSYANSITQAILSSPSGKMTLSEIYSWISSNLPYYRHKPTAW---------- 381
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2080336960 523 pggggsdKNAVRHNLSLHKCFVRVENV-----KGAVWTVDEREYQKRRPPKMTGSPTLVKN 578
Cdd:COG5025   382 -------QNSIRHNLSLNKSFEKVPRSasqpgKGCFWKIDYSYIYEKESKRNPRSPKKSPS 435
 
Name Accession Description Interval E-value
FH_FOXP4 cd20067
Forkhead (FH) domain found in Forkhead box protein P4 (FOXP4) and similar proteins; FOXP4, ...
468-571 2.68e-58

Forkhead (FH) domain found in Forkhead box protein P4 (FOXP4) and similar proteins; FOXP4, also called Forkhead-related protein-like A, is a transcriptional repressor that represses lung-specific expression. It is not required for T cell development, but is necessary for normal T cell cytokine recall responses to antigen following pathogenic infection. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410841 [Multi-domain]  Cd Length: 87  Bit Score: 191.49  E-value: 2.68e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20067     1 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATW-----------------KNAVRHNLSLHKCFVRVE 63
                          90       100
                  ....*....|....*....|....
gi 2080336960 548 NVKGAVWTVDEREYQKRRPPKMTG 571
Cdd:cd20067    64 NVKGAVWTVDELEYQKRRPPKMTG 87
FH_FOXP2 cd20065
Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2); FOXP2, also called CAG repeat ...
467-565 7.86e-53

Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2); FOXP2, also called CAG repeat protein 44, or Trinucleotide repeat-containing gene 10 protein, is a transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. It may also play a role in developing neural, gastrointestinal, and cardiovascular tissues. An arginine-to-histidine missense mutation (R553H) in the FOXP2 Forkhead domain has been linked to a severe speech and language disorder. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410839 [Multi-domain]  Cd Length: 82  Bit Score: 176.42  E-value: 7.86e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 467 VRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV 546
Cdd:cd20065     1 VRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATW-----------------KNAVRHNLSLHKCFVRV 63
                          90
                  ....*....|....*....
gi 2080336960 547 ENVKGAVWTVDEREYQKRR 565
Cdd:cd20065    64 ENVKGAVWTVDEVEYQKRR 82
FH_FOXP3 cd20066
Forkhead (FH) domain found in Forkhead box protein P3 (FOXP3) and similar proteins; FOXP3, ...
468-565 1.84e-49

Forkhead (FH) domain found in Forkhead box protein P3 (FOXP3) and similar proteins; FOXP3, also called Scurfin, is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg), which are required for maintaining self-tolerance. It may also have intrinsic regulatory function in conventional T (Tconv) cells. A deletion of the Forkhead domain arising from a frame-shift mutation in mouse FOXP3 is linked to the autoimmune disorder scurfy, and a similar congenital disease in humans is known as IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome). The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410840 [Multi-domain]  Cd Length: 81  Bit Score: 167.44  E-value: 1.84e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20066     1 RPPFTYASLIRWAILESPEKQLTLNEIYHWFTRMFAFFRNNTATW-----------------KNAVRHNLSLHKCFVRVE 63
                          90
                  ....*....|....*...
gi 2080336960 548 NVKGAVWTVDEREYQKRR 565
Cdd:cd20066    64 NEKGAVWTVDELEFQRRR 81
FH_FOXP cd20033
Forkhead (FH) domain found in the Forkhead box protein P (FOXP) subfamily; The FOXP subfamily ...
468-557 5.89e-49

Forkhead (FH) domain found in the Forkhead box protein P (FOXP) subfamily; The FOXP subfamily includes four winged helix transcription factors, FOXP1-4. They are involved in the development of the central nervous system. Mutations in FOXP1, also called Mac-1-regulated Forkhead (MFH), leads to developmental delay, intellectual disability, autism spectrum disorder, speech delay, and dysmorphic features. FOXP2, also called CAG repeat protein 44 or Trinucleotide repeat-containing gene 10 protein, is a transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. It may also play a role in developing neural, gastrointestinal and cardiovascular tissues. FOXP3, also called Scurfin, is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). FOXP4, also called Forkhead-related protein-like A, is a transcriptional repressor that represses lung-specific expression. It is necessary for normal T cell cytokine recall responses to antigen following pathogenic infection. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410807 [Multi-domain]  Cd Length: 73  Bit Score: 165.69  E-value: 5.89e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20033     1 RPPFTYASLIRQAILESPNKQLTLNEIYNWFQKTFAYFRRNAATW-----------------KNAVRHNLSLHKCFVRVE 63
                          90
                  ....*....|
gi 2080336960 548 NVKGAVWTVD 557
Cdd:cd20033    64 NVKGAVWTVD 73
FH_FOXP1 cd20064
Forkhead (FH) domain found in Forkhead box protein P1 (FOXP1); FOXP1, also called ...
465-568 1.18e-47

Forkhead (FH) domain found in Forkhead box protein P1 (FOXP1); FOXP1, also called Mac-1-regulated Forkhead (MFH), is a transcription factor that is widely expressed and has a broad range of functions. It has been shown to have a role in cardiac, lung, and lymphocyte development. Deregulation of FOXP1 is an important contributor to the pathogenesis of diffuse large B-cell lymphoma (DLBCL), suggesting it may function as an oncogene. Loss of FOXP1 expression in breast cancer is associated with a worse outcome, suggesting that FOXP1 may function as a tumor suppressor in some tissues. Haploinsufficiency of the FOXP1 gene leads to a neurodevelopmental disorder termed FOXP1 syndrome, characterized by developmental delay, intellectual disability, autism spectrum disorder, speech delay, and dysmorphic features. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410838 [Multi-domain]  Cd Length: 87  Bit Score: 162.61  E-value: 1.18e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 465 ADVRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFV 544
Cdd:cd20064     1 AEVRPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRRNAATW-----------------KNAVRHNLSLHKCFV 63
                          90       100
                  ....*....|....*....|....
gi 2080336960 545 RVENVKGAVWTVDEREYQKRRPPK 568
Cdd:cd20064    64 RVENVKGAVWTVDEIEFQKRRPQK 87
FOXP-CC pfam16159
FOXP coiled-coil domain; This domain, approximately 60-70 residues in length, is mainly found ...
304-371 6.98e-44

FOXP coiled-coil domain; This domain, approximately 60-70 residues in length, is mainly found in Forkhead box proteins in various Mammalia species. It is a coiled-coil domain, which modulates the dimeric associations of FOXP transcription factors. Several key disease mutations, for instance those found in the IPEX syndrome are located in this domain


Pssm-ID: 465036  Cd Length: 68  Bit Score: 151.68  E-value: 6.98e-44
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2080336960 304 LYGHGECKWPGCETLCEDLGQFIKHLNTEHALDDRSTAQCRVQMQVVQQLEIQLAKESERLQAMMAHL 371
Cdd:pfam16159   1 LFGHGVCRWPGCETVCEDFGSFLKHLNSEHALDDRSTAQCRVQMQVVQQLEIQLTKEKERLQAMMAHL 68
Forkhead pfam00250
Forkhead domain;
468-558 4.18e-32

Forkhead domain;


Pssm-ID: 459732  Cd Length: 86  Bit Score: 119.11  E-value: 4.18e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:pfam00250   1 KPPYSYAALIAMAILSSPEKKLTLSEIYEWISENFPYYRTADKGW-----------------QNSIRHNLSLNKCFVKVP 63
                          90
                  ....*....|....*.
gi 2080336960 548 NV-----KGAVWTVDE 558
Cdd:pfam00250  64 RPkdepgKGSYWTIDP 79
FH smart00339
FORKHEAD; FORKHEAD, also known as a "winged helix"
468-557 2.15e-31

FORKHEAD; FORKHEAD, also known as a "winged helix"


Pssm-ID: 214627 [Multi-domain]  Cd Length: 89  Bit Score: 117.34  E-value: 2.15e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960  468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:smart00339   1 KPPYSYIALIAMAILSSPDKRLTLSEIYKWIEDNFPYYRENRAGW-----------------QNSIRHNLSLNDCFVKVP 63
                           90
                   ....*....|....*
gi 2080336960  548 N-----VKGAVWTVD 557
Cdd:smart00339  64 RegdrpGKGSYWTLD 78
FH_FOX cd00059
Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar ...
469-555 1.22e-30

Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins; The FOX family comprises diverse tissue- and cell type-specific transcription factors with an evolutionary conserved "Forkhead (FH)" or "winged helix" DNA-binding domain. FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. The structure of the FH domain contains 2 flexible loops or "wings" in the C-terminal region, hence the term winged helix. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'. They participate in a variety of cellular processes, such as cell cycle progression, proliferation, differentiation, migration, metabolism, and DNA damage response. Their expression can be regulated by multiple factors, and they can act as co-activators and/or transcriptional repressors. Fifty FOX-encoding genes in humans have been categorized into 19 subfamilies based on protein sequence homology (FOXA to FOXS).


Pssm-ID: 410788 [Multi-domain]  Cd Length: 75  Bit Score: 114.54  E-value: 1.22e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 469 PPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVEN 548
Cdd:cd00059     1 PPYSYAALIALAILSSPDKRLTLSEIYKWIEDNFPYYRTATKGW-----------------KNSIRHNLSLNKCFVKVPR 63
                          90
                  ....*....|..
gi 2080336960 549 V-----KGAVWT 555
Cdd:cd00059    64 EpsdpgKGSYWT 75
FH_FOXJ2-like cd20024
Forkhead (FH) domain found in Forkhead box proteins, FOXJ2, FOXJ3 and similar proteins; The ...
468-556 2.90e-25

Forkhead (FH) domain found in Forkhead box proteins, FOXJ2, FOXJ3 and similar proteins; The FOXJ2-like subfamily includes two winged helix transcription factors, FOXJ2 and FOXJ3. FOXJ2, also called Forkhead homologous X (FHX), plays an important role in tumorigenesis, progression, and metastasis of certain cancers. It acts as a transcriptional activator that can bind to two different type of DNA binding sites. FOXJ3 is a transcription factor which regulates sperm function. It transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410798 [Multi-domain]  Cd Length: 77  Bit Score: 99.35  E-value: 2.90e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV- 546
Cdd:cd20024     1 KPPYSYATLITFAINSSPKKKMTLSEIYTWICENFPYYREAGTGW-----------------KNSIRHNLSLNKCFKKVp 63
                          90
                  ....*....|....
gi 2080336960 547 ----ENVKGAVWTV 556
Cdd:cd20024    64 rskdDPGKGSYWTL 77
FH_FOXQ2-like cd20035
Forkhead (FH) domain found in Forkhead box protein Q2 (FOXQ2) and similar proteins; FOXQ2 is ...
468-568 2.32e-23

Forkhead (FH) domain found in Forkhead box protein Q2 (FOXQ2) and similar proteins; FOXQ2 is the neurogenic ectoderm specification transcription factor that controls aboral development in cnidarians and anterior identity in bilaterians. It plays essential roles in epidermal development and central brain patterning. The foxQ2 gene is absent in placental mammals. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410809 [Multi-domain]  Cd Length: 95  Bit Score: 94.61  E-value: 2.32e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV- 546
Cdd:cd20035     1 KPSHSYVALIAKAILSSPEKKLVLSDIYQYIEENYPYFKSRGSSW-----------------KNSVRHNLSLNECFVKAg 63
                          90       100       110
                  ....*....|....*....|....*....|..
gi 2080336960 547 --ENVKGAVWTVDER--------EYQKRRPPK 568
Cdd:cd20035    64 raENGKGNYWTIHPAcledfekgDFRRRRARR 95
FH_FOXO cd20032
Forkhead (FH) domain found in the Forkhead box protein O (FOXO) subfamily; The FOXO subfamily ...
470-557 1.94e-21

Forkhead (FH) domain found in the Forkhead box protein O (FOXO) subfamily; The FOXO subfamily includes several winged helix transcription factors: FOXO1, FOXO3, FOXO4 and FOXO6. FOXO transcription factors are involved in the regulation of longevity phenomenon via insulin and insulin-like growth factor signaling. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members. FOXO1, also called Forkhead box protein O1A or Forkhead in rhabdomyosarcoma (FKHR), is a transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. FOXO3, also called AF6q21 protein or Forkhead in rhabdomyosarcoma-like 1 (FKHRL1), is a transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. It recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. FOXO4, also called Fork head domain transcription factor AFX1, is a transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO6 acts as a transcriptional activator that may play an important role on tumor invasion, metastasis, and prognosis. The FH domain is a winged helix DNA-binding domain.


Pssm-ID: 410806 [Multi-domain]  Cd Length: 80  Bit Score: 88.89  E-value: 1.94e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 470 PFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWKMASIpevtlpggggsdKNAVRHNLSLHKCFVRVENV 549
Cdd:cd20032     2 NMSYADLITKAIESSPDKRLTLQQIYDWMVRNVPYFKDKGDSNSSAGW------------KNSIRHNLSLHSRFVRVQNE 69
                          90
                  ....*....|.
gi 2080336960 550 ---KGAVWTVD 557
Cdd:cd20032    70 gtgKSSWWTLN 80
FH_FOXN2-like cd20031
Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2) and similar proteins; The ...
468-556 1.98e-21

Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2) and similar proteins; The FOXN2-like group includes two FOXN subfamily winged helix transcription factors, FOXN2 and FOXN3. FOXN2, also called human T-cell leukemia virus enhancer factor (HTLF), is a potential tumor suppressor that can facilitate replication fork reversal. It acts as a transcription factor that binds to the purine-rich region in human T-cell leukemia virus long terminal repeat (HTLV-I LTR). It may be a potential therapeutic and radiosensitization target for lung cancer. FOXN3, also called checkpoint suppressor 1, acts as a transcriptional repressor that may be involved in DNA damage-inducible cell cycle arrests (checkpoints). The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410805 [Multi-domain]  Cd Length: 76  Bit Score: 88.57  E-value: 1.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20031     1 KPPYSFSCLIFMAIESSPEKALPVKDIYSWIEKHFPYYRNAPSGW-----------------KNSIRHNLSLNKCFKKVE 63
                          90
                  ....*....|...
gi 2080336960 548 ----NVKGAVWTV 556
Cdd:cd20031    64 keknKGKGSLWCV 76
FH_FOXJ1 cd20023
Forkhead (FH) domain found in Forkhead box protein J1 (FOXJ1) and similar proteins; FOXJ1, ...
468-557 2.78e-20

Forkhead (FH) domain found in Forkhead box protein J1 (FOXJ1) and similar proteins; FOXJ1, also called Forkhead-related protein FKHL13 or hepatocyte nuclear factor 3 Forkhead homolog 4 (HFH-4), acts as a transcription factor specifically required for the formation of motile cilia. It acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. FOXJ1 binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). It activates the transcription of a variety of ciliary proteins in the developing brain and lung. The FH domain is a winged helix DNA-binding domain.


Pssm-ID: 410797 [Multi-domain]  Cd Length: 79  Bit Score: 85.54  E-value: 2.78e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV- 546
Cdd:cd20023     1 KPPYSYATLICMAMQASKKTKITLSAIYKWITDNFMYYRVADPTW-----------------QNSIRHNLSLNKCFIKVp 63
                          90
                  ....*....|....*
gi 2080336960 547 ----ENVKGAVWTVD 557
Cdd:cd20023    64 rskdEPGKGGFWRID 78
FH_FOXM cd20029
Forkhead (FH) domain found in the Forkhead box protein M (FOXM) subfamily; The FOXM subfamily ...
468-556 5.75e-20

Forkhead (FH) domain found in the Forkhead box protein M (FOXM) subfamily; The FOXM subfamily includes a winged helix transcription factor, FOXM1, which is also called Forkhead-related protein FKHL16, Hepatocyte nuclear factor 3 Forkhead homolog 11 (HFH-11), HNF-3/fork-head homolog 11, M-phase phosphoprotein 2, MPM-2 reactive phosphoprotein 2, transcription factor Trident, or Winged-helix factor from INS-1 cells. FOXM1 acts as a transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. It plays a role in the control of cell proliferation. It is also involved in DNA break repair, participating in the DNA damage checkpoint response. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410803 [Multi-domain]  Cd Length: 77  Bit Score: 84.40  E-value: 5.75e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFrRNTATwkmasipevtlPGGggsdKNAVRHNLSLHKCFVR-- 545
Cdd:cd20029     1 RPPYSYMALIQFAINSTEDKRMTLKEIYTWIEDHFPYF-KHTAK-----------PGW----KNSIRHNLSLHDIFVRet 64
                          90
                  ....*....|.
gi 2080336960 546 VENVKGAVWTV 556
Cdd:cd20029    65 SANGKGSFWTL 75
FH_FOXK cd20026
Forkhead (FH) domain found in the Forkhead box protein K (FOXK) subfamily; The FOXK subfamily ...
468-557 1.10e-19

Forkhead (FH) domain found in the Forkhead box protein K (FOXK) subfamily; The FOXK subfamily includes two winged helix transcription factors, FOXK1 and FOXK2. FOXK1, also called myocyte nuclear factor (MNF), acts as a transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin genes. It positively regulates Wnt/beta-catenin signaling by translocating dishevelled (DVL) proteins into the nucleus. It also reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression. In addition, FOXK1 plays important roles in multiple human cancers. FOXK2, also called cellular transcription factor ILF-1 or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to the HIV-1 long terminal repeat. FOXK2 may be involved in both, positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410800 [Multi-domain]  Cd Length: 78  Bit Score: 83.62  E-value: 1.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV- 546
Cdd:cd20026     1 KPPYSYAQLIVQAISSAPDKQLTLSGIYAYITKNYPYYRTADKGW-----------------QNSIRHNLSLNRYFIKVp 63
                          90
                  ....*....|....*
gi 2080336960 547 ----ENVKGAVWTVD 557
Cdd:cd20026    64 rsqeEPGKGSFWRID 78
FH_FOXL2 cd20028
Forkhead (FH) domain found in Forkhead box protein L2 (FOXL2) and similar proteins; FOXL2 is a ...
468-558 1.46e-18

Forkhead (FH) domain found in Forkhead box protein L2 (FOXL2) and similar proteins; FOXL2 is a transcriptional regulator that is essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Mutations in the FOXL2 gene cause blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) types I and II, a rare genetic disorder. In BPES type I, a complex eyelid malformation is associated with premature ovarian failure (POF), whereas in BPES type II, the eyelid defect occurs as an isolated entity. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410802 [Multi-domain]  Cd Length: 89  Bit Score: 80.95  E-value: 1.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV- 546
Cdd:cd20028     1 KPPYSYVALIAMAIRESPEKRLTLSGIYQYIIAKFPYYEKNKKGW-----------------QNSIRHNLSLNECFVKVp 63
                          90
                  ....*....|....*.
gi 2080336960 547 ----ENVKGAVWTVDE 558
Cdd:cd20028    64 reggGERKGNYWTLDP 79
FH_FOXG cd20021
Forkhead (FH) domain found in the Forkhead box protein G (FOXG) subfamily; The FOXG subfamily ...
468-557 4.24e-18

Forkhead (FH) domain found in the Forkhead box protein G (FOXG) subfamily; The FOXG subfamily includes a winged helix transcription factor FOXG1, which is also called brain factor 1 (BF-1), brain factor 2 (BF-2), Forkhead box protein G1A, Forkhead box protein G1B, Forkhead box protein G1C, Forkhead-related protein FKHL1, Forkhead-related protein FKHL2, or Forkhead-related protein FKHL3. FOXG1 acts as a transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. It is repetitively used in the sequential events of telencephalic development to control multi-steps of brain circuit formation ranging from cell cycle control to neuronal differentiation in a clade- and species-specific manner. Individuals with mutations in FOXG1 harbor "FOXG1-related encephalopathy", characterized by two clinical phenotypes/syndromes including microcephaly, developmental delay, severe cognitive disabilities, early-onset dyskinesia and hyperkinetic movements, stereotypies, epilepsy, and cerebral malformation for those with deletions or intragenic mutations of FOXG1. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410795 [Multi-domain]  Cd Length: 79  Bit Score: 79.15  E-value: 4.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWKmasipevtlpggggsdkNAVRHNLSLHKCFVRV- 546
Cdd:cd20021     1 KPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQ-----------------NSIRHNLSLNKCFVKVp 63
                          90
                  ....*....|....*
gi 2080336960 547 ----ENVKGAVWTVD 557
Cdd:cd20021    64 rhydDPGKGNYWMLD 78
FH_FOXJ3 cd20052
Forkhead (FH) domain found in Forkhead box protein J3 (FOXJ3) and similar proteins; FOXJ3 is a ...
468-557 1.77e-17

Forkhead (FH) domain found in Forkhead box protein J3 (FOXJ3) and similar proteins; FOXJ3 is a transcription factor which regulates sperm function. It transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity. Polymorphisms in the FOXJ3 gene may be associated with the development of rheumatoid arthritis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410826 [Multi-domain]  Cd Length: 79  Bit Score: 77.38  E-value: 1.77e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20052     2 KPPYSYANLITFAINSSPKKKMTLSEIYQWICDNFPYYREAGNGW-----------------KNSIRHNLSLNKCFLKVP 64
                          90
                  ....*....|....*
gi 2080336960 548 NV-----KGAVWTVD 557
Cdd:cd20052    65 RSkddpgKGSYWAID 79
FH_FOXH cd20022
Forkhead (FH) domain found in the Forkhead box protein H (FOXH) subfamily; The FOXH subfamily ...
468-557 5.30e-17

Forkhead (FH) domain found in the Forkhead box protein H (FOXH) subfamily; The FOXH subfamily includes a winged helix transcription factor, FOXH1, which is also called Forkhead activin signal transducer 1 (Fast-1), or Forkhead activin signal transducer 2 (Fast-2). FOXH1 acts as a transcriptional activator that recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. It is required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. FOXH1 forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410796 [Multi-domain]  Cd Length: 79  Bit Score: 76.25  E-value: 5.30e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20022     1 KPPYSYLAMIALAIQNSPEKRLTLSEIIKALSTMFPFFKGEYKGW-----------------KDSVRHNLSSNDCFVKVL 63
                          90
                  ....*....|....*.
gi 2080336960 548 N------VKGAVWTVD 557
Cdd:cd20022    64 KdpgkpqAKGNYWTVD 79
FH_FOXF cd20020
Forkhead (FH) domain found in the Forkhead box protein F (FOXF) subfamily; The FOXF subfamily ...
469-558 5.38e-17

Forkhead (FH) domain found in the Forkhead box protein F (FOXF) subfamily; The FOXF subfamily includes two winged helix transcription factors, FOXF1 and FOXF2, both of which are probable transcription activators for a number of lung-specific genes. FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins (ACD/MPV) suggest its involvement in ACD/MPV and lung organogenesis. FOXF2 is involved in programming organogenesis and regulating epithelial-to-mesenchymal transition (EMT) and cell proliferation. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410794  Cd Length: 78  Bit Score: 76.00  E-value: 5.38e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 469 PPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV-- 546
Cdd:cd20020     1 PPYSYIALIVMAIQASPTKRLTLSEIYQFLQQRFPFFRGPYQGW-----------------KNSVRHNLSLNECFIKLpk 63
                          90
                  ....*....|....*
gi 2080336960 547 ---ENVKGAVWTVDE 558
Cdd:cd20020    64 glgRPGKGHYWTIDP 78
FH_FOXE cd20019
Forkhead (FH) domain found in the Forkhead box protein E (FOXE) subfamily; The FOXE subfamily ...
468-557 6.17e-17

Forkhead (FH) domain found in the Forkhead box protein E (FOXE) subfamily; The FOXE subfamily includes two winged helix transcription factors, FOXE1 (also known as FOXE2) and FOXE3. FOXE1, also called Forkhead-related protein FKHL15, HFKH4, HNF-3/fork head-like protein 5 (HFKL5), or thyroid transcription factor 2 (TTF-2), is a transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. FOXE3, also called Forkhead-related protein FKHL12 or Forkhead-related transcription factor 8 (FREAC-8), is a transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis, and the cell cycle. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410793  Cd Length: 94  Bit Score: 76.38  E-value: 6.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20019     1 KPPYSYIALIAMAIANSPERKLTLGGIYKFIMERFPFYRDNSKKW-----------------QNSIRHNLTLNDCFVKIP 63
                          90
                  ....*....|....*
gi 2080336960 548 NV-----KGAVWTVD 557
Cdd:cd20019    64 REpgrpgKGNYWTLD 78
FH_FOXL1 cd20027
Forkhead (FH) domain found in Forkhead box protein L1 (FOXL1) and similar proteins; FOXL1, ...
467-559 1.01e-16

Forkhead (FH) domain found in Forkhead box protein L1 (FOXL1) and similar proteins; FOXL1, also called Forkhead-related protein FKHL11 or Forkhead-related transcription factor 7 (FREAC-7), acts as a transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. It may play a critical role in suppressing tumorigenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410801  Cd Length: 98  Bit Score: 76.00  E-value: 1.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 467 VRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV 546
Cdd:cd20027     2 QKPPYSYIALIAMAIKSAPDQKVTLNGIYQFIMDRFPYYHDNKQGW-----------------QNSIRHNLSLNDCFVKV 64
                          90
                  ....*....|....*...
gi 2080336960 547 ENV-----KGAVWTVDER 559
Cdd:cd20027    65 PREkgrpgKGNYWTLDPD 82
FH_FOXQ1-like cd20034
Forkhead (FH) domain found in Forkhead box protein Q1 (FOXQ1) and similar proteins; FOXQ1, ...
468-546 1.15e-16

Forkhead (FH) domain found in Forkhead box protein Q1 (FOXQ1) and similar proteins; FOXQ1, also called HNF-3/Forkhead-like protein 1 (HFH-1), or hepatocyte nuclear factor 3 Forkhead homolog 1, plays a role in hair follicle differentiation. It has also been reported to promote epithelial differentiation, inhibit smooth muscle differentiation, activate T cells and autoimmunity, and control mucin gene expression and granule content in stomach surface mucous cells. FOXQ1 is significantly associated with the pathogenesis of various tumor types including gastric, breast, colorectal, pancreatic, bladder and ovarian cancer, and glioma. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410808 [Multi-domain]  Cd Length: 79  Bit Score: 75.16  E-value: 1.15e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV 546
Cdd:cd20034     1 KPPYSYIALIAMAIRDSPSGRLTLAEINEYLMKKFPFFRGSYTGW-----------------RNSVRHNLSLNDCFVKV 62
FH_FOXJ2 cd20051
Forkhead (FH) domain found in Forkhead box protein J2 (FOXJ2) and similar proteins; FOXJ2, ...
468-557 1.36e-16

Forkhead (FH) domain found in Forkhead box protein J2 (FOXJ2) and similar proteins; FOXJ2, also called Fork head homologous X (FHX), plays an important role in tumorigenesis, progression, and metastasis of certain cancers. It acts as a transcriptional activator that can bind to two different type of DNA binding sites. It is specifically expressed in meiotic spermatocytes in adult mouse testes and appears to promote meiotic progression during spermatogenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410825 [Multi-domain]  Cd Length: 82  Bit Score: 75.03  E-value: 1.36e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV- 546
Cdd:cd20051     2 KPPYSYATLITYAINSSPAKKMTLSEIYRWICDNFPYYRNAGVGW-----------------KNSIRHNLSLNKCFRKVp 64
                          90
                  ....*....|....*
gi 2080336960 547 ----ENVKGAVWTVD 557
Cdd:cd20051    65 rprdDPGKGSYWMID 79
FH_FOXK2 cd20055
Forkhead (FH) domain found in Forkhead box protein K2 (FOXK2) and similar proteins; FOXK2, ...
466-566 2.25e-16

Forkhead (FH) domain found in Forkhead box protein K2 (FOXK2) and similar proteins; FOXK2, also called cellular transcription factor ILF-1 or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to the HIV-1 long terminal repeat. FOXK2 may be involved in both, positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410829 [Multi-domain]  Cd Length: 98  Bit Score: 74.85  E-value: 2.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 466 DVRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVR 545
Cdd:cd20055     1 DSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGW-----------------QNSIRHNLSLNRYFIK 63
                          90       100       110
                  ....*....|....*....|....*....|....
gi 2080336960 546 V-----ENVKGAVWTVD--------EREYQKRRP 566
Cdd:cd20055    64 VprsqeEPGKGSFWRIDpaseskliEQAFRKRRP 97
FH_FOXN3 cd20059
Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3); FOXN3, also called checkpoint ...
468-557 3.26e-16

Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3); FOXN3, also called checkpoint suppressor 1 (CHES1), acts as a transcriptional repressor that may be involved in DNA damage-inducible cell cycle arrests (checkpoints). It displays transcriptional inhibitory activity, and is involved in cell cycle regulation and tumorigenesis. Alterations in FOXN3 are found in of a variety of cancers including melanoma, osteosarcoma, and hepatocellular carcinoma. FOXN3 also regulates hepatic glucose utilization/metabolism by regulating gluconeogenic substrate selection. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410833 [Multi-domain]  Cd Length: 90  Bit Score: 74.12  E-value: 3.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20059     1 KPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGW-----------------KNSVRHNLSLNKCFKKVD 63
                          90
                  ....*....|....*.
gi 2080336960 548 NV------KGAVWTVD 557
Cdd:cd20059    64 KEkgqsigKGSLWCID 79
FH_FOXA cd20015
Forkhead (FH) domain found in the Forkhead box protein A (FOXA) subfamily; The FOXA subfamily ...
468-556 4.13e-16

Forkhead (FH) domain found in the Forkhead box protein A (FOXA) subfamily; The FOXA subfamily includes three winged helix transcription factors, FOXA1 (also called hepatocyte nuclear factor 3-alpha or transcription factor 3A), FOXA2 (also called hepatocyte nuclear factor 3-beta or transcription factor 3B), and FOXA3 (also called hepatocyte nuclear factor 3-gamma or transcription factor 3G). FOXA1 is essential for epithelial lineage differentiation and has been found to be upregulated in numerous cancers. FOXA2 controls cell differentiation. It is a key transcriptional regulator that maintains airway mucus homeostasis and may also have an important role in bone metabolism. FOXA3 acts as an essential transcriptional regulator engaged in adipogenesis and energy metabolism. This subfamily also includes Xenopus tropicalis FOXA4, Drosophila melanogaster protein fork head (dFKH), and similar proteins. FOXA4 is only present in amphibians, where it is required for the correct regionalization and maintenance of the central nervous system. dFKH promotes terminal as opposed to segmental development. In the absence of dFKH, this developmental switch does not occur. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410789 [Multi-domain]  Cd Length: 97  Bit Score: 74.20  E-value: 4.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20015     1 KPPYSYISLITMAIQQSPSKMLTLSEIYQWIMDLFPYYRQNQQRW-----------------QNSIRHSLSFNDCFVKVP 63
                          90
                  ....*....|....
gi 2080336960 548 NV-----KGAVWTV 556
Cdd:cd20015    64 RSpdkpgKGSYWTL 77
FH_FOXC cd20017
Forkhead (FH) domain found in the Forkhead box protein C (FOXC) subfamily; The FOXC subfamily ...
468-556 4.83e-16

Forkhead (FH) domain found in the Forkhead box protein C (FOXC) subfamily; The FOXC subfamily includes two winged helix transcription factors, FOXC1 (also called Forkhead-related protein FKHL7, or Forkhead-related transcription factor 3) and FOXC2 (also called Forkhead-related protein FKHL14, or Mesenchyme fork head protein 1). FOXC1 is a DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as the development of the eyes, bones, cardiovascular system, kidneys, and skin. FOXC2 acts as a transcriptional activator that might be involved in the formation of special mesenchymal tissues. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410791 [Multi-domain]  Cd Length: 77  Bit Score: 73.44  E-value: 4.83e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV- 546
Cdd:cd20017     1 KPPYSYIALIAMAIQNAPDKKITLNGIYQFIMDRFPFYRENKQGW-----------------QNSIRHNLSLNECFVKVp 63
                          90
                  ....*....|....
gi 2080336960 547 ----ENVKGAVWTV 556
Cdd:cd20017    64 rddkKPGKGSYWTL 77
FH_FOXC1 cd20044
Forkhead (FH) domain found in Forkhead box protein C1 (FOXC1) and similar proteins; FOXC1, ...
467-561 1.61e-15

Forkhead (FH) domain found in Forkhead box protein C1 (FOXC1) and similar proteins; FOXC1, also called Forkhead-related protein FKHL7, or Forkhead-related transcription factor 3 (FREAC-3), is a DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as the development of the eyes, bones, cardiovascular system, kidneys, and skin. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410818  Cd Length: 93  Bit Score: 72.43  E-value: 1.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 467 VRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV 546
Cdd:cd20044     5 VKPPYSYIALITMAIQNAPDKKITLNGIYQFIMERFPFYRDNKQGW-----------------QNSIRHNLSLNECFVKV 67
                          90       100
                  ....*....|....*....|
gi 2080336960 547 -----ENVKGAVWTVDEREY 561
Cdd:cd20044    68 prddkKPGKGSYWTLDPDSY 87
FH_FOXN2 cd20058
Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2); FOXN2, also called human T-cell ...
468-557 2.15e-15

Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2); FOXN2, also called human T-cell leukemia virus enhancer factor (HTLF), is a potential tumor suppressor that can facilitate replication fork reversal. It acts as a transcription factor that binds to the purine-rich region in human T-cell leukemia virus long terminal repeat (HTLV-I LTR). It may be a potential therapeutic and radiosensitization target for lung cancer. FOXN2 has also been found to be down-regulated in breast cancer, where it regulates migration, invasion, and epithelial-mesenchymal transition. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410832 [Multi-domain]  Cd Length: 82  Bit Score: 71.60  E-value: 2.15e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20058     2 KPPYSFSLLIYMAIEHSPNKCLPVKEIYSWILEHFPYFSTAPTGW-----------------KNSVRHNLSLNKCFRKVE 64
                          90
                  ....*....|....*.
gi 2080336960 548 ------NVKGAVWTVD 557
Cdd:cd20058    65 rshgkvNGKGSLWCVD 80
FH_FOXI cd20025
Forkhead (FH) domain found in the Forkhead box protein I (FOXI) subfamily; The FOXI subfamily ...
469-557 3.22e-15

Forkhead (FH) domain found in the Forkhead box protein I (FOXI) subfamily; The FOXI subfamily includes three human winged helix transcription factors, FOXI1-3, Xenopus laevis FoxI1c, and similar proteins. FOXI1 acts as a transcriptional activator required for the development of normal hearing, sense of balance, and kidney function. FOXI2 may act as a transcriptional activator that plays a possible role in controlling cellular identity. Loss of function mutations in the FOXI2 gene may contribute to ectodermal dysplasia. FOXI3 plays a critical role in the development of the inner ear and jaw. It is a regulator of ectodermal development. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410799 [Multi-domain]  Cd Length: 77  Bit Score: 71.02  E-value: 3.22e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 469 PPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV-- 546
Cdd:cd20025     1 PPYSYSALIAMAIQSAPEKKLTLSQIYQYVAENFPFYKRSKAGW-----------------QNSIRHNLSLNDCFKKVpr 63
                          90
                  ....*....|....
gi 2080336960 547 -ENV--KGAVWTVD 557
Cdd:cd20025    64 dEDDpgKGNYWTLD 77
FH_FOXC2 cd20045
Forkhead (FH) domain found in Forkhead box protein C2 (FOXC2) and similar proteins; FOXC2, ...
467-561 4.13e-15

Forkhead (FH) domain found in Forkhead box protein C2 (FOXC2) and similar proteins; FOXC2, also called Forkhead-related protein FKHL14, Mesenchyme fork head protein 1 (MFH-1 protein), or transcription factor FKH-14, acts as a transcriptional activator that might be involved in the formation of special mesenchymal tissues. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410819  Cd Length: 90  Bit Score: 71.27  E-value: 4.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 467 VRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV 546
Cdd:cd20045     2 VKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRENKQGW-----------------QNSIRHNLSLNECFVKV 64
                          90       100
                  ....*....|....*....|
gi 2080336960 547 -----ENVKGAVWTVDEREY 561
Cdd:cd20045    65 prddkKPGKGSYWTLDPDSY 84
FH_FOXB cd20016
Forkhead (FH) domain found in the Forkhead box protein B (FOXB) subfamily; The FOXB subfamily ...
468-556 1.51e-14

Forkhead (FH) domain found in the Forkhead box protein B (FOXB) subfamily; The FOXB subfamily includes two winged helix transcription factors, FOXB1 (also called transcription factor FKH-5) and FOXB2 (also called transcription factor FKH-4). FOXB1 controls development of mammary glands and regions of the central nervous system (CNS) that regulate the milk-ejection reflex. It is essential for access of mammillothalamic axons to the thalamus. FOXB2 may act as a tumor suppressor; it has been found to inhibit the malignant characteristics of the pancreatic cancer cell line Panc-1 in vitro. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410790 [Multi-domain]  Cd Length: 79  Bit Score: 69.07  E-value: 1.51e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV- 546
Cdd:cd20016     1 KPPYSYISLTAMAIQSSPEKMLPLSDIYKFIMDRFPYYRKNTQRW-----------------QNSLRHNLSFNDCFIKIp 63
                          90
                  ....*....|....
gi 2080336960 547 ----ENVKGAVWTV 556
Cdd:cd20016    64 rrpdRPGKGSYWAL 77
FH_FOXO4 cd20062
Forkhead (FH) domain found in Forkhead box protein O4 (FOXO4) and similar proteins; FOXO4, ...
472-548 1.77e-14

Forkhead (FH) domain found in Forkhead box protein O4 (FOXO4) and similar proteins; FOXO4, also called Fork head domain transcription factor AFX1, is a transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. The FH domain is a winged helix DNA-binding domain. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members.


Pssm-ID: 410836 [Multi-domain]  Cd Length: 86  Bit Score: 69.35  E-value: 1.77e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 472 TYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFR-----RNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV 546
Cdd:cd20062     8 SYAELISQAIESSPEKRLTLAQIYEWMVKSVPYFKdkgdsNSSAGW-----------------KNSIRHNLSLHSKFIKV 70

                  ..
gi 2080336960 547 EN 548
Cdd:cd20062    71 HN 72
FH_FOXA1 cd20038
Forkhead (FH) domain found in Forkhead box protein A1 (FOXA1) and similar proteins; FOXA1, ...
468-556 1.82e-14

Forkhead (FH) domain found in Forkhead box protein A1 (FOXA1) and similar proteins; FOXA1, also called hepatocyte nuclear factor 3-alpha (HNF-3-alpha or HNF-3A) or transcription factor 3A (TCF-3A), acts as a transcription factor that is essential for epithelial lineage differentiation. It has been found to be upregulated in numerous cancers. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410812 [Multi-domain]  Cd Length: 112  Bit Score: 70.16  E-value: 1.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20038    14 KPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRW-----------------QNSIRHSLSFNDCFVKVA 76
                          90
                  ....*....|....
gi 2080336960 548 NV-----KGAVWTV 556
Cdd:cd20038    77 RSpdkpgKGSYWTL 90
FH_FOXO3 cd20061
Forkhead (FH) domain found in Forkhead box protein O3 (FOXO3); FOXO3, also called AF6q21 ...
471-557 2.18e-14

Forkhead (FH) domain found in Forkhead box protein O3 (FOXO3); FOXO3, also called AF6q21 protein or Forkhead in rhabdomyosarcoma-like 1 (FKHRL1), is a transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. It recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. The FH domain is a winged helix DNA-binding domain. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members.


Pssm-ID: 410835 [Multi-domain]  Cd Length: 83  Bit Score: 68.93  E-value: 2.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 471 FTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFR-----RNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVR 545
Cdd:cd20061     4 LSYADLITRAIESSPDKRLTLSQIYDWMVRCVPYFKdkgdsNSSAGW-----------------KNSIRHNLSLHSRFIR 66
                          90
                  ....*....|....*
gi 2080336960 546 VENV---KGAVWTVD 557
Cdd:cd20061    67 VQNEgtgKSSWWMIN 81
FH_FOXO6 cd20063
Forkhead (FH) domain found in Forkhead box protein O6 (FOXO6) and similar proteins; FOXO6 acts ...
472-548 2.33e-14

Forkhead (FH) domain found in Forkhead box protein O6 (FOXO6) and similar proteins; FOXO6 acts as a transcriptional activator that may play an important role on tumor invasion, metastasis and prognosis. The FH domain is a winged helix DNA-binding domain. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members.


Pssm-ID: 410837 [Multi-domain]  Cd Length: 88  Bit Score: 68.92  E-value: 2.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 472 TYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFR-----RNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV 546
Cdd:cd20063     4 SYADLITKAIESSPDKRLTLSQIYDWMVRYVPYFKdkgdsNSSAGW-----------------KNSIRHNLSLHTRFIRV 66

                  ..
gi 2080336960 547 EN 548
Cdd:cd20063    67 QN 68
FH_FOXA3 cd20040
Forkhead (FH) domain found in Forkhead box protein A3 (FOXA3) and similar proteins; FOXA3, ...
468-556 4.88e-14

Forkhead (FH) domain found in Forkhead box protein A3 (FOXA3) and similar proteins; FOXA3, also called hepatocyte nuclear factor 3-gamma (HNF-3-gamma or HNF-3G), fork head-related protein FKH H3, or transcription factor 3G (TCF-3G), acts as an essential transcriptional regulator engaged in adipogenesis and energy metabolism. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410814 [Multi-domain]  Cd Length: 102  Bit Score: 68.60  E-value: 4.88e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20040     3 KPPYSYISLITMAIQQAPSKMLTLNEIYQWIMDLFPYYRENQQRW-----------------QNSIRHSLSFNDCFVKVA 65
                          90
                  ....*....|....
gi 2080336960 548 NV-----KGAVWTV 556
Cdd:cd20040    66 RSpdkpgKGSYWAL 79
FH_FOXS1 cd20037
Forkhead (FH) domain found in Forkhead box protein S1 (FOXS1); FOXS1, also called ...
468-557 4.95e-14

Forkhead (FH) domain found in Forkhead box protein S1 (FOXS1); FOXS1, also called Forkhead-like 18 protein or Forkhead-related transcription factor 10 (FREAC-10), is a transcriptional repressor that suppresses transcription from the FASLG, FOXO3, and FOXO4 promoters. It may have a role in the organization of the testicular vasculature. It has also been implicated in energy turnover, motor function, and body weight. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410811  Cd Length: 100  Bit Score: 68.50  E-value: 4.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWKmasipevtlpggggsdkNAVRHNLSLHKCFVRV- 546
Cdd:cd20037     2 KPPYSYIALIAMAIQSSPGQRATLSGIYRYIMGRFAFYRHNRPGWQ-----------------NSIRHNLSLNECFVKVp 64
                          90
                  ....*....|....*
gi 2080336960 547 ----ENVKGAVWTVD 557
Cdd:cd20037    65 rddrKPGKGSYWTLD 79
FH_FOXA2 cd20039
Forkhead (FH) domain found in Forkhead box protein A2 (FOXA2) and similar proteins; FOXA2, ...
468-556 8.97e-14

Forkhead (FH) domain found in Forkhead box protein A2 (FOXA2) and similar proteins; FOXA2, also called hepatocyte nuclear factor 3-beta (HNF-3-beta or HNF-3B) or transcription factor 3B (TCF-3B), acts as a core transcription factor that controls cell differentiation. It is a key transcriptional regulator that maintains airway mucus homeostasis. It may also have an important role in bone metabolism. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410813 [Multi-domain]  Cd Length: 104  Bit Score: 67.83  E-value: 8.97e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20039     5 KPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRW-----------------QNSIRHSLSFNDCFLKVP 67
                          90
                  ....*....|....
gi 2080336960 548 NV-----KGAVWTV 556
Cdd:cd20039    68 RSpdkpgKGSFWTL 81
FH_dFKH cd20041
Forkhead (FH) domain found in Drosophila melanogaster protein fork head (dFKH) and similar ...
468-556 1.19e-13

Forkhead (FH) domain found in Drosophila melanogaster protein fork head (dFKH) and similar proteins; dFKH promotes terminal as opposed to segmental development. In the absence of dFKH, this developmental switch does not occur. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410815 [Multi-domain]  Cd Length: 98  Bit Score: 67.30  E-value: 1.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20041     1 KPPYSYISLITMAIQNSPNKMVTLSEIYQFIMDLFPFYRQNQQRW-----------------QNSIRHSLSFNDCFVKVP 63
                          90
                  ....*....|....
gi 2080336960 548 NV-----KGAVWTV 556
Cdd:cd20041    64 RTpdkpgKGSFWTL 77
FH_FOXK1 cd20054
Forkhead (FH) domain found in Forkhead box protein K1 (FOXK1) and similar proteins; FOXK1, ...
468-565 1.27e-13

Forkhead (FH) domain found in Forkhead box protein K1 (FOXK1) and similar proteins; FOXK1, also called myocyte nuclear factor (MNF), acts as a transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin genes. It positively regulates Wnt/beta-catenin signaling by translocating dishevelled (DVL) proteins into the nucleus. It also reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression. In addition, FOXK1 plays important roles in multiple human cancers. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410828 [Multi-domain]  Cd Length: 101  Bit Score: 67.16  E-value: 1.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV- 546
Cdd:cd20054     3 KPPYSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPYYRTADKGW-----------------QNSIRHNLSLNRYFIKVp 65
                          90       100       110
                  ....*....|....*....|....*....|.
gi 2080336960 547 ----ENVKGAVWTVD--------EREYQKRR 565
Cdd:cd20054    66 rsqeEPGKGSFWRIDpaseaklvEQAFRKRR 96
FH_FOXI1 cd20053
Forkhead (FH) domain found in Forkhead box protein I1 (FOXI1) and similar proteins; FOXI1 is ...
467-557 1.52e-13

Forkhead (FH) domain found in Forkhead box protein I1 (FOXI1) and similar proteins; FOXI1 is also called Forkhead-related protein FKHL10, Forkhead-related transcription factor 6 (FREAC-6), Hepatocyte nuclear factor 3 Forkhead homolog 3 (HFH-3), or HNF-3/fork-head homolog 3. It is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, kidney, and epididymis, and is required for the development of normal hearing, sense of balance, and kidney function. Its epididymal expression is required for male fertility. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410827  Cd Length: 100  Bit Score: 67.05  E-value: 1.52e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 467 VRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV 546
Cdd:cd20053     3 VRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGW-----------------QNSIRHNLSLNDCFKKV 65
                          90
                  ....*....|....*.
gi 2080336960 547 -----ENVKGAVWTVD 557
Cdd:cd20053    66 prdedDPGKGNYWTLD 81
FH_FOXD4-like cd20048
Forkhead (FH) domain found in Forkhead box protein D4 (FOXD4) and similar proteins; FOXD4, ...
468-557 1.77e-13

Forkhead (FH) domain found in Forkhead box protein D4 (FOXD4) and similar proteins; FOXD4, also called Forkhead-related protein FKHL9, Forkhead-related transcription factor 5 (FREAC-5), or myeloid factor-alpha, is essential for establishing neural cell fate and for neuronal differentiation. The family also includes Forkhead box protein D4-like proteins, FOXD4L1-6. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410822  Cd Length: 96  Bit Score: 66.84  E-value: 1.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20048     1 KPPYSYIALITMAILQSPHKRLTLSGICAFISGRFPYYRRKFPAW-----------------QNSIRHNLSLNDCFVKIP 63
                          90
                  ....*....|....*
gi 2080336960 548 NV-----KGAVWTVD 557
Cdd:cd20048    64 REpghpgKGNYWSLD 78
FH_FOXD cd20018
Forkhead (FH) domain found in the Forkhead box protein D (FOXD) subfamily; The FOXD subfamily ...
468-557 2.27e-13

Forkhead (FH) domain found in the Forkhead box protein D (FOXD) subfamily; The FOXD subfamily includes four winged helix transcription factors, FOXD1-4. FOXD1, also called Forkhead-related protein FKHL8 or Forkhead-related transcription factor 4 (FREAC-4), is involved in transcriptional activation of Placental Growth Factor (PGF) and the complement component (C3) genes. It plays an important role in early embryonic development and organogenesis, and functions as an oncogene in several cancers. FOXD2, also called Forkhead-related protein FKHL17 or Forkhead-related transcription factor 9 (FREAC-9), is a probable transcription factor involved in embryogenesis and somatogenesis. FOXD3, also called HNF3/FH transcription factor genesis, acts as a transcriptional repressor that binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3'. It also acts as a transcriptional activator. It promotes development of neural crest cells from neural tube progenitors and restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. FOXD3 is required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. FOXD4, also called Forkhead-related protein FKHL9 or Forkhead-related transcription factor 5 (FREAC-5), is essential for establishing neural cell fate and for neuronal differentiation. The family also includes Forkhead box protein D4-like proteins, FOXD4L1-6. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410792 [Multi-domain]  Cd Length: 78  Bit Score: 65.66  E-value: 2.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20018     1 KPPYSYIALITMAILQSPQKKLTLSGICEFIMNRFPYYREKFPAW-----------------QNSIRHNLSLNDCFVKIP 63
                          90
                  ....*....|....*
gi 2080336960 548 NV-----KGAVWTVD 557
Cdd:cd20018    64 REpgnpgKGNYWTLD 78
FH_FOXN1-like cd20030
Forkhead (FH) domain found in Forkhead box protein N1 (FOXN1) and similar proteins; The ...
468-558 4.75e-13

Forkhead (FH) domain found in Forkhead box protein N1 (FOXN1) and similar proteins; The FOXN1-like group includes two FOXN subfamily winged helix transcription factors, FOXN1 and FOXN4. FOXN1, also called winged helix transcription factor nude, acts as a transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs), both in the prenatal and postnatal thymus. FOXN4 acts as a transcription factor essential for neural and some non-neural tissue development, such as retina and lung, respectively. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410804 [Multi-domain]  Cd Length: 81  Bit Score: 64.77  E-value: 4.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWKmasipevtlpggggsdkNAVRHNLSLHKCFVRVE 547
Cdd:cd20030     1 KPAYSYSCLIAMALKNSRTGCLPVSEIYSFMCENFPYFKTAPDGWK-----------------NSVRHNLSLNKCFEKIE 63
                          90
                  ....*....|....*...
gi 2080336960 548 NV-------KGAVWTVDE 558
Cdd:cd20030    64 RPdgngssrKGCLWALNP 81
FH_FOXD3 cd20047
Forkhead (FH) domain found in Forkhead box protein D3 (FOXD3) and similar proteins; FOXD3, ...
467-557 5.24e-13

Forkhead (FH) domain found in Forkhead box protein D3 (FOXD3) and similar proteins; FOXD3, also called HNF3/FH transcription factor genesis, acts as a transcriptional repressor that binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3'. It also acts as a transcriptional activator. It promotes development of neural crest cells from neural tube progenitors and restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. FOXD3 is required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. The FH domain is a winged helix DNA-binding domain.


Pssm-ID: 410821  Cd Length: 97  Bit Score: 65.51  E-value: 5.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 467 VRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV 546
Cdd:cd20047     1 VKPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPAW-----------------QNSIRHNLSLNDCFVKI 63
                          90
                  ....*....|....*.
gi 2080336960 547 ENV-----KGAVWTVD 557
Cdd:cd20047    64 PREpgnpgKGNYWTLD 79
FH_FOXD1_D2-like cd20046
Forkhead (FH) domain found in Forkhead box proteins FOXD1, FOXD2 and similar proteins; FOXD1, ...
468-557 7.57e-13

Forkhead (FH) domain found in Forkhead box proteins FOXD1, FOXD2 and similar proteins; FOXD1, also called Forkhead-related protein FKHL8, or Forkhead-related transcription factor 4 (FREAC-4), is involved in transcriptional activation of Placental Growth Factor (PGF) and the complement component (C3) genes. It plays an important role in early embryonic development and organogenesis, and functions as an oncogene in several cancers. FOXD2, also called Forkhead-related protein FKHL17, or Forkhead-related transcription factor 9 (FREAC-9), is a probable transcription factor involved in embryogenesis and somatogenesis. It has been found that long noncoding RNA FOXD2 adjacent opposite strand RNA1 (lncRNA FOXD2-AS1) expression is upregulated in various human malignancies, including gastric, lung, bladder, colorectal, nasopharyngeal, esophageal, hepatocellular, thyroid and skin cancer. It is a promising candidate as a new biomarker and therapeutic target for cancer diagnosis/prognostication due to high tissue specificity and elevated efficiency. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410820  Cd Length: 99  Bit Score: 65.10  E-value: 7.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20046     1 KPPYSYIALITMAILQSPKKRLTLSEICEFISNRFPYYREKFPAW-----------------QNSIRHNLSLNDCFVKIP 63
                          90
                  ....*....|....*
gi 2080336960 548 NV-----KGAVWTVD 557
Cdd:cd20046    64 REpgnpgKGNYWTLD 78
FH_FOXF1 cd20049
Forkhead (FH) domain found in Forkhead box protein F1 (FOXF1) and similar proteins; FOXF1, ...
469-566 1.05e-12

Forkhead (FH) domain found in Forkhead box protein F1 (FOXF1) and similar proteins; FOXF1, also called Forkhead-related activator 1 (FREAC-1), Forkhead-related protein FKHL5, or Forkhead-related transcription factor 1, is a probable transcription activator for a number of lung-specific genes. FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins (ACD/MPV) suggest its involvement in ACD/MPV and lung organogenesis. The role of FOXF1 in cancer is conflicting; its loss in some cancers suggests a tumor suppressive function, but its abundance in others is associated with protumorigenic and metastatic traits. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410823  Cd Length: 99  Bit Score: 64.70  E-value: 1.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 469 PPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVEN 548
Cdd:cd20049     1 PPYSYIALIVMAIQSSPTKRLTLSEIYQFLQSRFPFFRGSYQGW-----------------KNSVRHNLSLNECFIKLPK 63
                          90       100       110
                  ....*....|....*....|....*....|
gi 2080336960 549 -----VKGAVWTVD-------EREYQKRRP 566
Cdd:cd20049    64 glgrpGKGHYWTIDpasefmfEEGSFRRRP 93
FH_FOXF2 cd20050
Forkhead (FH) domain found in Forkhead box protein F2 (FOXF2) and similar proteins; FOXF2, ...
469-566 1.63e-12

Forkhead (FH) domain found in Forkhead box protein F2 (FOXF2) and similar proteins; FOXF2, also called Forkhead-related activator 2 (FREAC-2), Forkhead-related protein FKHL6, or Forkhead-related transcription factor 2, is a probable transcription activator for a number of lung-specific genes. It is involved in programming organogenesis and regulating epithelial-to-mesenchymal transition (EMT) and cell proliferation. FOXF2 dysregulation is critical for tumorigenesis of various tissue types. Its expression correlates with good prognosis in patients with early non-invasive stages of breast cancer, but with poor prognosis in advanced breast cancer. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410824  Cd Length: 93  Bit Score: 63.94  E-value: 1.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 469 PPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVEN 548
Cdd:cd20050     1 PPYSYIALIVMAIQSSPSKKLTLSEIYQFLQARFPFFRGAYQGW-----------------KNSVRHNLSLNECFIKLPK 63
                          90       100       110
                  ....*....|....*....|....*....|
gi 2080336960 549 V-----KGAVWTVD-EREYQ------KRRP 566
Cdd:cd20050    64 GlgrpgKGHYWTIDpASEFMfeegsfRRRP 93
FH_FOXB1 cd20042
Forkhead (FH) domain found in Forkhead box protein B1 (FOXB1) and similar proteins; FOXB1, ...
465-556 6.26e-12

Forkhead (FH) domain found in Forkhead box protein B1 (FOXB1) and similar proteins; FOXB1, also called transcription factor FKH-5, is a winged helix transcription factor that controls development of mammary glands and regions of the central nervous system (CNS) that regulate the milk-ejection reflex. It is essential for access of mammillothalamic axons to the thalamus. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410816 [Multi-domain]  Cd Length: 92  Bit Score: 62.08  E-value: 6.26e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 465 ADVRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFV 544
Cdd:cd20042     3 SDQKPPYSYISLTAMAIQSSPEKMLPLSEIYKFIMDRFPYYRENTQRW-----------------QNSLRHNLSFNDCFI 65
                          90
                  ....*....|....*..
gi 2080336960 545 RV-----ENVKGAVWTV 556
Cdd:cd20042    66 KIprrpdQPGKGSFWAL 82
COG5025 COG5025
Transcription factor of the Forkhead/HNF3 family [Transcription];
365-578 9.31e-12

Transcription factor of the Forkhead/HNF3 family [Transcription];


Pssm-ID: 227358 [Multi-domain]  Cd Length: 610  Bit Score: 68.30  E-value: 9.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 365 QAMMAHLHMRPSEPKPFSQPLNPVPGSSSFSKVTVSAADSFPDGLVHP--PTSAAAPVTPLRPPGLSSASLHSGGPARRR 442
Cdd:COG5025   240 NLDVSLGHHISQPSTHTPVLDNHSSGEENISRINNSSQIDSPTPNYRMssIDSSVNPSRLANNKDEGRKGSKSSPVPKDA 319
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 443 SSDKFCSPISSELAQNhefyknadVRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtl 522
Cdd:COG5025   320 APPSTLSDLSADVNRT--------SKPAFSYANSITQAILSSPSGKMTLSEIYSWISSNLPYYRHKPTAW---------- 381
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2080336960 523 pggggsdKNAVRHNLSLHKCFVRVENV-----KGAVWTVDEREYQKRRPPKMTGSPTLVKN 578
Cdd:COG5025   382 -------QNSIRHNLSLNKSFEKVPRSasqpgKGCFWKIDYSYIYEKESKRNPRSPKKSPS 435
FH_FOXO1 cd20060
Forkhead (FH) domain found in Forkhead box protein O1 (FOXO1); FOXO1, also called Forkhead box ...
471-548 6.84e-11

Forkhead (FH) domain found in Forkhead box protein O1 (FOXO1); FOXO1, also called Forkhead box protein O1A or Forkhead in rhabdomyosarcoma (FKHR), is a transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. It binds to the insulin response element (IRE) with the consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with the consensus sequence 5'-TT[G/A]TTTAC-3'. The FH domain is a winged helix DNA-binding domain.


Pssm-ID: 410834 [Multi-domain]  Cd Length: 99  Bit Score: 59.47  E-value: 6.84e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 471 FTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFR-----RNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVR 545
Cdd:cd20060    13 LSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKdkgdsNSSAGW-----------------KNSIRHNLSLHSKFIR 75

                  ...
gi 2080336960 546 VEN 548
Cdd:cd20060    76 VQN 78
FH_FOXN1 cd20056
Forkhead (FH) domain found in Forkhead box protein N1 (FOXN1); FOXN1, also called winged helix ...
468-563 5.54e-10

Forkhead (FH) domain found in Forkhead box protein N1 (FOXN1); FOXN1, also called winged helix transcription factor nude, acts as a transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs), both in the prenatal and postnatal thymus. It is also an important factor in controlling the skin wound healing process, as it actively participates in re-epithelialization and is responsible for scar formation. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410830 [Multi-domain]  Cd Length: 97  Bit Score: 56.65  E-value: 5.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWKmasipevtlpggggsdkNAVRHNLSLHKCFVRVE 547
Cdd:cd20056     2 KPIYSYSILIFMALKNSKTGSLPVSEIYNFMTEHFPYFKTAPDGWK-----------------NSVRHNLSLNKCFEKVE 64
                          90       100
                  ....*....|....*....|..
gi 2080336960 548 NV------KGAVWTVDEREYQK 563
Cdd:cd20056    65 NKsgsssrKGCLWALNPAKIDK 86
FH_FOXB2 cd20043
Forkhead (FH) domain found in Forkhead box protein B2 (FOXB2) and similar proteins; FOXB2, ...
465-556 4.61e-09

Forkhead (FH) domain found in Forkhead box protein B2 (FOXB2) and similar proteins; FOXB2, also called transcription factor FKH-4, may act as a transcription factor. It may also act as a tumor suppressor; it has been found to inhibit the malignant characteristics of the pancreatic cancer cell line Panc-1 in vitro. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410817 [Multi-domain]  Cd Length: 110  Bit Score: 54.68  E-value: 4.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 465 ADVRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFV 544
Cdd:cd20043    10 SDQKPPYSYISLTAMAIQSSQEKMLPLSDIYKFIMDRFPYYRENTQRW-----------------QNSLRHNLSFNDCFI 72
                          90
                  ....*....|....*..
gi 2080336960 545 RV-----ENVKGAVWTV 556
Cdd:cd20043    73 KIprrpdQPGKGSFWAL 89
FH_FOXN4 cd20057
Forkhead (FH) domain found in Forkhead box protein N4 (FOXN4); FOXN4 acts as a transcription ...
468-557 4.10e-08

Forkhead (FH) domain found in Forkhead box protein N4 (FOXN4); FOXN4 acts as a transcription factor essential for neural and some non-neural tissue development, such as retina and lung, respectively. During development of the central nervous system, FOXN4 is required in specifying the amacrine and horizontal cell fates from multipotent retinal progenitors, while suppressing alternative photoreceptor cell fates. In non-neural tissues, it plays an essential role in specifying the atrioventricular canal and is indirectly required for patterning the distal airway during lung development. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410831 [Multi-domain]  Cd Length: 106  Bit Score: 51.63  E-value: 4.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWKmasipevtlpggggsdkNAVRHNLSLHKCFVRVE 547
Cdd:cd20057     6 KPIYSYSCLIAMALKNSKTGSLPVSEIYSFMKEHFPYFKTAPDGWK-----------------NSVRHNLSLNKCFEKVE 68
                          90
                  ....*....|....*.
gi 2080336960 548 NV------KGAVWTVD 557
Cdd:cd20057    69 NKmsgssrKGCLWALN 84
FH_FOXR cd20036
Forkhead (FH) domain found in the Forkhead box protein R (FOXR) subfamily; The FOXR subfamily ...
468-547 1.98e-06

Forkhead (FH) domain found in the Forkhead box protein R (FOXR) subfamily; The FOXR subfamily includes two winged helix transcription factors, FOXR1-2. FOXR1, also called Forkhead box protein N5 (FOXN5), is required for proper cell division and survival possibly via the p21 and mTOR pathways. FOXR2, also called Forkhead box protein N6 (FOXN6), is an important player in a wide range of cellular processes such as proliferation, migration, differentiation, and apoptosis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410810 [Multi-domain]  Cd Length: 87  Bit Score: 46.15  E-value: 1.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNwFTR-MFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV 546
Cdd:cd20036     3 KPPLSYPNLIALALRNSETGSLNVQEIYD-FIRfHFPFFRTAPDGW-----------------KNSVRHNLSFSDSFEKV 64

                  .
gi 2080336960 547 E 547
Cdd:cd20036    65 P 65
COG5025 COG5025
Transcription factor of the Forkhead/HNF3 family [Transcription];
429-619 5.72e-06

Transcription factor of the Forkhead/HNF3 family [Transcription];


Pssm-ID: 227358 [Multi-domain]  Cd Length: 610  Bit Score: 49.42  E-value: 5.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 429 SSASLHSGGPARRRSSDKFCSPISSELAQNHEFYKNADV--RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFR 506
Cdd:COG5025    45 LSSPKAPTRVSLDYSNSLNRSVGSEEIQAYAKLAGSNWTyyVPPYSYATGRGLAILNSPDKPLTLSKIYTWIHNTFFYYA 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 507 RNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVEN-----VKGAVWTVDEREYQKRRPPKMTGSPTLVKNMI- 580
Cdd:COG5025   125 KVVSRW-----------------QNSIRHNLSLNDAFIKIEGrngakVKGHFWSIGPGHETQFLKSGLRLDGGGKQMMFt 187
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2080336960 581 -----SGLSYGALNASYQAALAESSFPLLNSPGMLNPGSASSLL 619
Cdd:COG5025   188 lpsstEIKITYSSTHSMPLLESNDSLNSNNERELLDIIKSSALI 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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