FOXP coiled-coil domain; This domain, approximately 60-70 residues in length, is mainly found in Forkhead box proteins in various Mammalia species. It is a coiled-coil domain, which modulates the dimeric associations of FOXP transcription factors. Several key disease mutations, for instance those found in the IPEX syndrome are located in this domain

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2080336960 304 LYGHGECKWPGCETLCEDLGQFIKHLNTEHALDDRSTAQCRVQMQVVQQLEIQLAKESERLQAMMAHL 371
Cdd:pfam16159   1 LFGHGVCRWPGCETVCEDFGSFLKHLNSEHALDDRSTAQCRVQMQVVQQLEIQLTKEKERLQAMMAHL 68

FOXP coiled-coil domain; This domain, approximately 60-70 residues in length, is mainly found in Forkhead box proteins in various Mammalia species. It is a coiled-coil domain, which modulates the dimeric associations of FOXP transcription factors. Several key disease mutations, for instance those found in the IPEX syndrome are located in this domain

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2080336960 304 LYGHGECKWPGCETLCEDLGQFIKHLNTEHALDDRSTAQCRVQMQVVQQLEIQLAKESERLQAMMAHL 371
Cdd:pfam16159   1 LFGHGVCRWPGCETVCEDFGSFLKHLNSEHALDDRSTAQCRVQMQVVQQLEIQLTKEKERLQAMMAHL 68

FORKHEAD; FORKHEAD, also known as a "winged helix"

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960  468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:smart00339   1 KPPYSYIALIAMAILSSPDKRLTLSEIYKWIEDNFPYYRENRAGW-----------------QNSIRHNLSLNDCFVKVP 63

                           90
                   ....*....|....*
gi 2080336960  548 N-----VKGAVWTVD 557
Cdd:smart00339  64 RegdrpGKGSYWTLD 78

Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2); FOXP2, also called CAG repeat protein 44, or Trinucleotide repeat-containing gene 10 protein, is a transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. It may also play a role in developing neural, gastrointestinal, and cardiovascular tissues. An arginine-to-histidine missense mutation (R553H) in the FOXP2 Forkhead domain has been linked to a severe speech and language disorder. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 467 VRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV 546
Cdd:cd20065     1 VRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATW-----------------KNAVRHNLSLHKCFVRV 63

                          90
                  ....*....|....*....
gi 2080336960 547 ENVKGAVWTVDEREYQKRR 565
Cdd:cd20065    64 ENVKGAVWTVDEVEYQKRR 82

Forkhead (FH) domain found in the Forkhead box protein P (FOXP) subfamily; The FOXP subfamily includes four winged helix transcription factors, FOXP1-4. They are involved in the development of the central nervous system. Mutations in FOXP1, also called Mac-1-regulated Forkhead (MFH), leads to developmental delay, intellectual disability, autism spectrum disorder, speech delay, and dysmorphic features. FOXP2, also called CAG repeat protein 44 or Trinucleotide repeat-containing gene 10 protein, is a transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. It may also play a role in developing neural, gastrointestinal and cardiovascular tissues. FOXP3, also called Scurfin, is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). FOXP4, also called Forkhead-related protein-like A, is a transcriptional repressor that represses lung-specific expression. It is necessary for normal T cell cytokine recall responses to antigen following pathogenic infection. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20033     1 RPPFTYASLIRQAILESPNKQLTLNEIYNWFQKTFAYFRRNAATW-----------------KNAVRHNLSLHKCFVRVE 63

                          90
                  ....*....|
gi 2080336960 548 NVKGAVWTVD 557
Cdd:cd20033    64 NVKGAVWTVD 73

FOXP coiled-coil domain; This domain, approximately 60-70 residues in length, is mainly found in Forkhead box proteins in various Mammalia species. It is a coiled-coil domain, which modulates the dimeric associations of FOXP transcription factors. Several key disease mutations, for instance those found in the IPEX syndrome are located in this domain

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2080336960 304 LYGHGECKWPGCETLCEDLGQFIKHLNTEHALDDRSTAQCRVQMQVVQQLEIQLAKESERLQAMMAHL 371
Cdd:pfam16159   1 LFGHGVCRWPGCETVCEDFGSFLKHLNSEHALDDRSTAQCRVQMQVVQQLEIQLTKEKERLQAMMAHL 68

FORKHEAD; FORKHEAD, also known as a "winged helix"

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960  468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:smart00339   1 KPPYSYIALIAMAILSSPDKRLTLSEIYKWIEDNFPYYRENRAGW-----------------QNSIRHNLSLNDCFVKVP 63

                           90
                   ....*....|....*
gi 2080336960  548 N-----VKGAVWTVD 557
Cdd:smart00339  64 RegdrpGKGSYWTLD 78

Forkhead (FH) domain found in Forkhead box proteins, FOXJ2, FOXJ3 and similar proteins; The FOXJ2-like subfamily includes two winged helix transcription factors, FOXJ2 and FOXJ3. FOXJ2, also called Forkhead homologous X (FHX), plays an important role in tumorigenesis, progression, and metastasis of certain cancers. It acts as a transcriptional activator that can bind to two different type of DNA binding sites. FOXJ3 is a transcription factor which regulates sperm function. It transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV- 546
Cdd:cd20024     1 KPPYSYATLITFAINSSPKKKMTLSEIYTWICENFPYYREAGTGW-----------------KNSIRHNLSLNKCFKKVp 63

                          90
                  ....*....|....
gi 2080336960 547 ----ENVKGAVWTV 556
Cdd:cd20024    64 rskdDPGKGSYWTL 77

Forkhead (FH) domain found in the Forkhead box protein O (FOXO) subfamily; The FOXO subfamily includes several winged helix transcription factors: FOXO1, FOXO3, FOXO4 and FOXO6. FOXO transcription factors are involved in the regulation of longevity phenomenon via insulin and insulin-like growth factor signaling. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members. FOXO1, also called Forkhead box protein O1A or Forkhead in rhabdomyosarcoma (FKHR), is a transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. FOXO3, also called AF6q21 protein or Forkhead in rhabdomyosarcoma-like 1 (FKHRL1), is a transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. It recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. FOXO4, also called Fork head domain transcription factor AFX1, is a transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO6 acts as a transcriptional activator that may play an important role on tumor invasion, metastasis, and prognosis. The FH domain is a winged helix DNA-binding domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 470 PFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWKMASIpevtlpggggsdKNAVRHNLSLHKCFVRVENV 549
Cdd:cd20032     2 NMSYADLITKAIESSPDKRLTLQQIYDWMVRNVPYFKDKGDSNSSAGW------------KNSIRHNLSLHSRFVRVQNE 69

                          90
                  ....*....|.
gi 2080336960 550 ---KGAVWTVD 557
Cdd:cd20032    70 gtgKSSWWTLN 80

Forkhead (FH) domain found in Forkhead box protein J1 (FOXJ1) and similar proteins; FOXJ1, also called Forkhead-related protein FKHL13 or hepatocyte nuclear factor 3 Forkhead homolog 4 (HFH-4), acts as a transcription factor specifically required for the formation of motile cilia. It acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. FOXJ1 binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). It activates the transcription of a variety of ciliary proteins in the developing brain and lung. The FH domain is a winged helix DNA-binding domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV- 546
Cdd:cd20023     1 KPPYSYATLICMAMQASKKTKITLSAIYKWITDNFMYYRVADPTW-----------------QNSIRHNLSLNKCFIKVp 63

                          90
                  ....*....|....*
gi 2080336960 547 ----ENVKGAVWTVD 557
Cdd:cd20023    64 rskdEPGKGGFWRID 78

Forkhead (FH) domain found in the Forkhead box protein K (FOXK) subfamily; The FOXK subfamily includes two winged helix transcription factors, FOXK1 and FOXK2. FOXK1, also called myocyte nuclear factor (MNF), acts as a transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin genes. It positively regulates Wnt/beta-catenin signaling by translocating dishevelled (DVL) proteins into the nucleus. It also reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression. In addition, FOXK1 plays important roles in multiple human cancers. FOXK2, also called cellular transcription factor ILF-1 or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to the HIV-1 long terminal repeat. FOXK2 may be involved in both, positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV- 546
Cdd:cd20026     1 KPPYSYAQLIVQAISSAPDKQLTLSGIYAYITKNYPYYRTADKGW-----------------QNSIRHNLSLNRYFIKVp 63

                          90
                  ....*....|....*
gi 2080336960 547 ----ENVKGAVWTVD 557
Cdd:cd20026    64 rsqeEPGKGSFWRID 78

Forkhead (FH) domain found in the Forkhead box protein G (FOXG) subfamily; The FOXG subfamily includes a winged helix transcription factor FOXG1, which is also called brain factor 1 (BF-1), brain factor 2 (BF-2), Forkhead box protein G1A, Forkhead box protein G1B, Forkhead box protein G1C, Forkhead-related protein FKHL1, Forkhead-related protein FKHL2, or Forkhead-related protein FKHL3. FOXG1 acts as a transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. It is repetitively used in the sequential events of telencephalic development to control multi-steps of brain circuit formation ranging from cell cycle control to neuronal differentiation in a clade- and species-specific manner. Individuals with mutations in FOXG1 harbor "FOXG1-related encephalopathy", characterized by two clinical phenotypes/syndromes including microcephaly, developmental delay, severe cognitive disabilities, early-onset dyskinesia and hyperkinetic movements, stereotypies, epilepsy, and cerebral malformation for those with deletions or intragenic mutations of FOXG1. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWKmasipevtlpggggsdkNAVRHNLSLHKCFVRV- 546
Cdd:cd20021     1 KPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQ-----------------NSIRHNLSLNKCFVKVp 63

                          90
                  ....*....|....*
gi 2080336960 547 ----ENVKGAVWTVD 557
Cdd:cd20021    64 rhydDPGKGNYWMLD 78

Forkhead (FH) domain found in the Forkhead box protein H (FOXH) subfamily; The FOXH subfamily includes a winged helix transcription factor, FOXH1, which is also called Forkhead activin signal transducer 1 (Fast-1), or Forkhead activin signal transducer 2 (Fast-2). FOXH1 acts as a transcriptional activator that recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. It is required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. FOXH1 forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20022     1 KPPYSYLAMIALAIQNSPEKRLTLSEIIKALSTMFPFFKGEYKGW-----------------KDSVRHNLSSNDCFVKVL 63

                          90
                  ....*....|....*.
gi 2080336960 548 N------VKGAVWTVD 557
Cdd:cd20022    64 KdpgkpqAKGNYWTVD 79

Forkhead (FH) domain found in the Forkhead box protein E (FOXE) subfamily; The FOXE subfamily includes two winged helix transcription factors, FOXE1 (also known as FOXE2) and FOXE3. FOXE1, also called Forkhead-related protein FKHL15, HFKH4, HNF-3/fork head-like protein 5 (HFKL5), or thyroid transcription factor 2 (TTF-2), is a transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. FOXE3, also called Forkhead-related protein FKHL12 or Forkhead-related transcription factor 8 (FREAC-8), is a transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis, and the cell cycle. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20019     1 KPPYSYIALIAMAIANSPERKLTLGGIYKFIMERFPFYRDNSKKW-----------------QNSIRHNLTLNDCFVKIP 63

                          90
                  ....*....|....*
gi 2080336960 548 NV-----KGAVWTVD 557
Cdd:cd20019    64 REpgrpgKGNYWTLD 78

Forkhead (FH) domain found in Forkhead box protein Q1 (FOXQ1) and similar proteins; FOXQ1, also called HNF-3/Forkhead-like protein 1 (HFH-1), or hepatocyte nuclear factor 3 Forkhead homolog 1, plays a role in hair follicle differentiation. It has also been reported to promote epithelial differentiation, inhibit smooth muscle differentiation, activate T cells and autoimmunity, and control mucin gene expression and granule content in stomach surface mucous cells. FOXQ1 is significantly associated with the pathogenesis of various tumor types including gastric, breast, colorectal, pancreatic, bladder and ovarian cancer, and glioma. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV 546
Cdd:cd20034     1 KPPYSYIALIAMAIRDSPSGRLTLAEINEYLMKKFPFFRGSYTGW-----------------RNSVRHNLSLNDCFVKV 62

Forkhead (FH) domain found in Forkhead box protein K2 (FOXK2) and similar proteins; FOXK2, also called cellular transcription factor ILF-1 or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to the HIV-1 long terminal repeat. FOXK2 may be involved in both, positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 466 DVRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVR 545
Cdd:cd20055     1 DSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGW-----------------QNSIRHNLSLNRYFIK 63

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2080336960 546 V-----ENVKGAVWTVD--------EREYQKRRP 566
Cdd:cd20055    64 VprsqeEPGKGSFWRIDpaseskliEQAFRKRRP 97

Forkhead (FH) domain found in the Forkhead box protein A (FOXA) subfamily; The FOXA subfamily includes three winged helix transcription factors, FOXA1 (also called hepatocyte nuclear factor 3-alpha or transcription factor 3A), FOXA2 (also called hepatocyte nuclear factor 3-beta or transcription factor 3B), and FOXA3 (also called hepatocyte nuclear factor 3-gamma or transcription factor 3G). FOXA1 is essential for epithelial lineage differentiation and has been found to be upregulated in numerous cancers. FOXA2 controls cell differentiation. It is a key transcriptional regulator that maintains airway mucus homeostasis and may also have an important role in bone metabolism. FOXA3 acts as an essential transcriptional regulator engaged in adipogenesis and energy metabolism. This subfamily also includes Xenopus tropicalis FOXA4, Drosophila melanogaster protein fork head (dFKH), and similar proteins. FOXA4 is only present in amphibians, where it is required for the correct regionalization and maintenance of the central nervous system. dFKH promotes terminal as opposed to segmental development. In the absence of dFKH, this developmental switch does not occur. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20015     1 KPPYSYISLITMAIQQSPSKMLTLSEIYQWIMDLFPYYRQNQQRW-----------------QNSIRHSLSFNDCFVKVP 63

                          90
                  ....*....|....
gi 2080336960 548 NV-----KGAVWTV 556
Cdd:cd20015    64 RSpdkpgKGSYWTL 77

Forkhead (FH) domain found in Forkhead box protein C1 (FOXC1) and similar proteins; FOXC1, also called Forkhead-related protein FKHL7, or Forkhead-related transcription factor 3 (FREAC-3), is a DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as the development of the eyes, bones, cardiovascular system, kidneys, and skin. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 467 VRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV 546
Cdd:cd20044     5 VKPPYSYIALITMAIQNAPDKKITLNGIYQFIMERFPFYRDNKQGW-----------------QNSIRHNLSLNECFVKV 67

                          90       100
                  ....*....|....*....|
gi 2080336960 547 -----ENVKGAVWTVDEREY 561
Cdd:cd20044    68 prddkKPGKGSYWTLDPDSY 87

Forkhead (FH) domain found in the Forkhead box protein I (FOXI) subfamily; The FOXI subfamily includes three human winged helix transcription factors, FOXI1-3, Xenopus laevis FoxI1c, and similar proteins. FOXI1 acts as a transcriptional activator required for the development of normal hearing, sense of balance, and kidney function. FOXI2 may act as a transcriptional activator that plays a possible role in controlling cellular identity. Loss of function mutations in the FOXI2 gene may contribute to ectodermal dysplasia. FOXI3 plays a critical role in the development of the inner ear and jaw. It is a regulator of ectodermal development. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 469 PPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV-- 546
Cdd:cd20025     1 PPYSYSALIAMAIQSAPEKKLTLSQIYQYVAENFPFYKRSKAGW-----------------QNSIRHNLSLNDCFKKVpr 63

                          90
                  ....*....|....
gi 2080336960 547 -ENV--KGAVWTVD 557
Cdd:cd20025    64 dEDDpgKGNYWTLD 77

Forkhead (FH) domain found in the Forkhead box protein B (FOXB) subfamily; The FOXB subfamily includes two winged helix transcription factors, FOXB1 (also called transcription factor FKH-5) and FOXB2 (also called transcription factor FKH-4). FOXB1 controls development of mammary glands and regions of the central nervous system (CNS) that regulate the milk-ejection reflex. It is essential for access of mammillothalamic axons to the thalamus. FOXB2 may act as a tumor suppressor; it has been found to inhibit the malignant characteristics of the pancreatic cancer cell line Panc-1 in vitro. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV- 546
Cdd:cd20016     1 KPPYSYISLTAMAIQSSPEKMLPLSDIYKFIMDRFPYYRKNTQRW-----------------QNSLRHNLSFNDCFIKIp 63

                          90
                  ....*....|....
gi 2080336960 547 ----ENVKGAVWTV 556
Cdd:cd20016    64 rrpdRPGKGSYWAL 77

Forkhead (FH) domain found in Forkhead box protein A1 (FOXA1) and similar proteins; FOXA1, also called hepatocyte nuclear factor 3-alpha (HNF-3-alpha or HNF-3A) or transcription factor 3A (TCF-3A), acts as a transcription factor that is essential for epithelial lineage differentiation. It has been found to be upregulated in numerous cancers. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20038    14 KPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRW-----------------QNSIRHSLSFNDCFVKVA 76

                          90
                  ....*....|....
gi 2080336960 548 NV-----KGAVWTV 556
Cdd:cd20038    77 RSpdkpgKGSYWTL 90

Forkhead (FH) domain found in Forkhead box protein O6 (FOXO6) and similar proteins; FOXO6 acts as a transcriptional activator that may play an important role on tumor invasion, metastasis and prognosis. The FH domain is a winged helix DNA-binding domain. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 472 TYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFR-----RNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV 546
Cdd:cd20063     4 SYADLITKAIESSPDKRLTLSQIYDWMVRYVPYFKdkgdsNSSAGW-----------------KNSIRHNLSLHTRFIRV 66

                  ..
gi 2080336960 547 EN 548
Cdd:cd20063    67 QN 68

Forkhead (FH) domain found in Forkhead box protein S1 (FOXS1); FOXS1, also called Forkhead-like 18 protein or Forkhead-related transcription factor 10 (FREAC-10), is a transcriptional repressor that suppresses transcription from the FASLG, FOXO3, and FOXO4 promoters. It may have a role in the organization of the testicular vasculature. It has also been implicated in energy turnover, motor function, and body weight. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWKmasipevtlpggggsdkNAVRHNLSLHKCFVRV- 546
Cdd:cd20037     2 KPPYSYIALIAMAIQSSPGQRATLSGIYRYIMGRFAFYRHNRPGWQ-----------------NSIRHNLSLNECFVKVp 64

                          90
                  ....*....|....*
gi 2080336960 547 ----ENVKGAVWTVD 557
Cdd:cd20037    65 rddrKPGKGSYWTLD 79

Forkhead (FH) domain found in Drosophila melanogaster protein fork head (dFKH) and similar proteins; dFKH promotes terminal as opposed to segmental development. In the absence of dFKH, this developmental switch does not occur. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20041     1 KPPYSYISLITMAIQNSPNKMVTLSEIYQFIMDLFPFYRQNQQRW-----------------QNSIRHSLSFNDCFVKVP 63

                          90
                  ....*....|....
gi 2080336960 548 NV-----KGAVWTV 556
Cdd:cd20041    64 RTpdkpgKGSFWTL 77

Forkhead (FH) domain found in Forkhead box protein I1 (FOXI1) and similar proteins; FOXI1 is also called Forkhead-related protein FKHL10, Forkhead-related transcription factor 6 (FREAC-6), Hepatocyte nuclear factor 3 Forkhead homolog 3 (HFH-3), or HNF-3/fork-head homolog 3. It is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, kidney, and epididymis, and is required for the development of normal hearing, sense of balance, and kidney function. Its epididymal expression is required for male fertility. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 467 VRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV 546
Cdd:cd20053     3 VRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGW-----------------QNSIRHNLSLNDCFKKV 65

                          90
                  ....*....|....*.
gi 2080336960 547 -----ENVKGAVWTVD 557
Cdd:cd20053    66 prdedDPGKGNYWTLD 81

Forkhead (FH) domain found in the Forkhead box protein D (FOXD) subfamily; The FOXD subfamily includes four winged helix transcription factors, FOXD1-4. FOXD1, also called Forkhead-related protein FKHL8 or Forkhead-related transcription factor 4 (FREAC-4), is involved in transcriptional activation of Placental Growth Factor (PGF) and the complement component (C3) genes. It plays an important role in early embryonic development and organogenesis, and functions as an oncogene in several cancers. FOXD2, also called Forkhead-related protein FKHL17 or Forkhead-related transcription factor 9 (FREAC-9), is a probable transcription factor involved in embryogenesis and somatogenesis. FOXD3, also called HNF3/FH transcription factor genesis, acts as a transcriptional repressor that binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3'. It also acts as a transcriptional activator. It promotes development of neural crest cells from neural tube progenitors and restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. FOXD3 is required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. FOXD4, also called Forkhead-related protein FKHL9 or Forkhead-related transcription factor 5 (FREAC-5), is essential for establishing neural cell fate and for neuronal differentiation. The family also includes Forkhead box protein D4-like proteins, FOXD4L1-6. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVE 547
Cdd:cd20018     1 KPPYSYIALITMAILQSPQKKLTLSGICEFIMNRFPYYREKFPAW-----------------QNSIRHNLSLNDCFVKIP 63

                          90
                  ....*....|....*
gi 2080336960 548 NV-----KGAVWTVD 557
Cdd:cd20018    64 REpgnpgKGNYWTLD 78

Forkhead (FH) domain found in Forkhead box protein D3 (FOXD3) and similar proteins; FOXD3, also called HNF3/FH transcription factor genesis, acts as a transcriptional repressor that binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3'. It also acts as a transcriptional activator. It promotes development of neural crest cells from neural tube progenitors and restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. FOXD3 is required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. The FH domain is a winged helix DNA-binding domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 467 VRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV 546
Cdd:cd20047     1 VKPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPAW-----------------QNSIRHNLSLNDCFVKI 63

                          90
                  ....*....|....*.
gi 2080336960 547 ENV-----KGAVWTVD 557
Cdd:cd20047    64 PREpgnpgKGNYWTLD 79

Forkhead (FH) domain found in Forkhead box protein F1 (FOXF1) and similar proteins; FOXF1, also called Forkhead-related activator 1 (FREAC-1), Forkhead-related protein FKHL5, or Forkhead-related transcription factor 1, is a probable transcription activator for a number of lung-specific genes. FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins (ACD/MPV) suggest its involvement in ACD/MPV and lung organogenesis. The role of FOXF1 in cancer is conflicting; its loss in some cancers suggests a tumor suppressive function, but its abundance in others is associated with protumorigenic and metastatic traits. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 469 PPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRVEN 548
Cdd:cd20049     1 PPYSYIALIVMAIQSSPTKRLTLSEIYQFLQSRFPFFRGSYQGW-----------------KNSVRHNLSLNECFIKLPK 63

                          90       100       110
                  ....*....|....*....|....*....|
gi 2080336960 549 -----VKGAVWTVD-------EREYQKRRP 566
Cdd:cd20049    64 glgrpGKGHYWTIDpasefmfEEGSFRRRP 93

Forkhead (FH) domain found in Forkhead box protein B1 (FOXB1) and similar proteins; FOXB1, also called transcription factor FKH-5, is a winged helix transcription factor that controls development of mammary glands and regions of the central nervous system (CNS) that regulate the milk-ejection reflex. It is essential for access of mammillothalamic axons to the thalamus. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 465 ADVRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFV 544
Cdd:cd20042     3 SDQKPPYSYISLTAMAIQSSPEKMLPLSEIYKFIMDRFPYYRENTQRW-----------------QNSLRHNLSFNDCFI 65

                          90
                  ....*....|....*..
gi 2080336960 545 RV-----ENVKGAVWTV 556
Cdd:cd20042    66 KIprrpdQPGKGSFWAL 82

Forkhead (FH) domain found in Forkhead box protein O1 (FOXO1); FOXO1, also called Forkhead box protein O1A or Forkhead in rhabdomyosarcoma (FKHR), is a transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. It binds to the insulin response element (IRE) with the consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with the consensus sequence 5'-TT[G/A]TTTAC-3'. The FH domain is a winged helix DNA-binding domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 471 FTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFR-----RNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVR 545
Cdd:cd20060    13 LSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKdkgdsNSSAGW-----------------KNSIRHNLSLHSKFIR 75

                  ...
gi 2080336960 546 VEN 548
Cdd:cd20060    76 VQN 78

Forkhead (FH) domain found in Forkhead box protein B2 (FOXB2) and similar proteins; FOXB2, also called transcription factor FKH-4, may act as a transcription factor. It may also act as a tumor suppressor; it has been found to inhibit the malignant characteristics of the pancreatic cancer cell line Panc-1 in vitro. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 465 ADVRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFV 544
Cdd:cd20043    10 SDQKPPYSYISLTAMAIQSSQEKMLPLSDIYKFIMDRFPYYRENTQRW-----------------QNSLRHNLSFNDCFI 72

                          90
                  ....*....|....*..
gi 2080336960 545 RV-----ENVKGAVWTV 556
Cdd:cd20043    73 KIprrpdQPGKGSFWAL 89

Forkhead (FH) domain found in the Forkhead box protein R (FOXR) subfamily; The FOXR subfamily includes two winged helix transcription factors, FOXR1-2. FOXR1, also called Forkhead box protein N5 (FOXN5), is required for proper cell division and survival possibly via the p21 and mTOR pathways. FOXR2, also called Forkhead box protein N6 (FOXN6), is an important player in a wide range of cellular processes such as proliferation, migration, differentiation, and apoptosis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2080336960 468 RPPFTYASLIRQAILETPDRQLTLNEIYNwFTR-MFAYFRRNTATWkmasipevtlpggggsdKNAVRHNLSLHKCFVRV 546
Cdd:cd20036     3 KPPLSYPNLIALALRNSETGSLNVQEIYD-FIRfHFPFFRTAPDGW-----------------KNSVRHNLSFSDSFEKV 64

                  .
gi 2080336960 547 E 547
Cdd:cd20036    65 P 65