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Conserved domains on  [gi|2113570075|ref|XP_044140725|]
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hemopexin [Bufo gargarizans]

Protein Classification

HX domain-containing protein( domain architecture ID 10056665)

HX domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
49-239 1.07e-30

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 117.03  E-value: 1.07e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113570075  49 DRCSDEGFGAITLDDkGVMHYFRGDSVWMGFQG-PTQPLNKI---FPGMTGPVDAAFRNHNENRalehqrTYLFKGSLVW 124
Cdd:cd00094     2 DACDPLSFDAVTTLR-GELYFFKGRYFWRLSPGkPPGSPFLIssfWPSLPSPVDAAFERPDTGK------IYFFKGDKYW 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113570075 125 SYFEGQLVMGYPRLIgQEFPGVP--DNLDAAVECHRgecrTDSILFFKGGHVYIYS------AQEEPPIKQRQWAALGS- 195
Cdd:cd00094    75 VYTGKNLEPGYPKPI-SDLGFPPtvKQIDAALRWPD----NGKTYFFKGDKYWRYDektqkmDPGYPKLIETDFPGVPDk 149
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2113570075 196 CTATVRWL-GRYYCFNDIYFTRFDPVSGQVLSPRPLDARDYFVRC 239
Cdd:cd00094   150 VDAAFRWLdGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
HX super family cl02471
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
259-448 2.26e-28

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


The actual alignment was detected with superfamily member cd00094:

Pssm-ID: 413329 [Multi-domain]  Cd Length: 194  Bit Score: 110.86  E-value: 2.26e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113570075 259 DRCSKRSFEAFSSDDKSWtYAYRGGWFFRLDASKDGWHAWPLSHTWKNLQGTVDAVFNHENR--MYFIQGSQVIVYISDQ 336
Cdd:cd00094     2 DACDPLSFDAVTTLRGEL-YFFKGRYFWRLSPGKPPGSPFLISSFWPSLPSPVDAAFERPDTgkIYFFKGDKYWVYTGKN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113570075 337 MyipVLGYPKPIQEEWEVSGVTAVDAAFTCPHSSDLYLLRGNKLILVDLNTR-------KRSGEDRTIIHADVDSAMCNT 409
Cdd:cd00094    81 L---EPGYPKPISDLGFPPTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQkmdpgypKLIETDFPGVPDKVDAAFRWL 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2113570075 410 HG-LYLFHGQSFYHYKNVEELLSSkvaPAPGNIASYFMDC 448
Cdd:cd00094   158 DGyYYFFKGDQYWRFDPRSKEVRV---GYPLKISSDWLGC 194
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
49-239 1.07e-30

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 117.03  E-value: 1.07e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113570075  49 DRCSDEGFGAITLDDkGVMHYFRGDSVWMGFQG-PTQPLNKI---FPGMTGPVDAAFRNHNENRalehqrTYLFKGSLVW 124
Cdd:cd00094     2 DACDPLSFDAVTTLR-GELYFFKGRYFWRLSPGkPPGSPFLIssfWPSLPSPVDAAFERPDTGK------IYFFKGDKYW 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113570075 125 SYFEGQLVMGYPRLIgQEFPGVP--DNLDAAVECHRgecrTDSILFFKGGHVYIYS------AQEEPPIKQRQWAALGS- 195
Cdd:cd00094    75 VYTGKNLEPGYPKPI-SDLGFPPtvKQIDAALRWPD----NGKTYFFKGDKYWRYDektqkmDPGYPKLIETDFPGVPDk 149
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2113570075 196 CTATVRWL-GRYYCFNDIYFTRFDPVSGQVLSPRPLDARDYFVRC 239
Cdd:cd00094   150 VDAAFRWLdGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
259-448 2.26e-28

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 110.86  E-value: 2.26e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113570075 259 DRCSKRSFEAFSSDDKSWtYAYRGGWFFRLDASKDGWHAWPLSHTWKNLQGTVDAVFNHENR--MYFIQGSQVIVYISDQ 336
Cdd:cd00094     2 DACDPLSFDAVTTLRGEL-YFFKGRYFWRLSPGKPPGSPFLISSFWPSLPSPVDAAFERPDTgkIYFFKGDKYWVYTGKN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113570075 337 MyipVLGYPKPIQEEWEVSGVTAVDAAFTCPHSSDLYLLRGNKLILVDLNTR-------KRSGEDRTIIHADVDSAMCNT 409
Cdd:cd00094    81 L---EPGYPKPISDLGFPPTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQkmdpgypKLIETDFPGVPDKVDAAFRWL 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2113570075 410 HG-LYLFHGQSFYHYKNVEELLSSkvaPAPGNIASYFMDC 448
Cdd:cd00094   158 DGyYYFFKGDQYWRFDPRSKEVRV---GYPLKISSDWLGC 194
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
97-147 1.15e-06

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 44.93  E-value: 1.15e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2113570075   97 VDAAFRNHNEnralehqRTYLFKGSLVWSYFEGQLVMGYPRLIGQEFPGVP 147
Cdd:smart00120   1 IDAAFELRDG-------KTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLP 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
97-147 1.88e-05

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 41.78  E-value: 1.88e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2113570075  97 VDAAFRnhnenraLEHQRTYLFKGSLVWSYFEGQLVMGYPRLIGqEFPGVP 147
Cdd:pfam00045   1 IDAAFE-------DRDGKTYFFKGRKYWRFDPQRVEPGYPKLIS-DFPGLP 43
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
49-239 1.07e-30

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 117.03  E-value: 1.07e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113570075  49 DRCSDEGFGAITLDDkGVMHYFRGDSVWMGFQG-PTQPLNKI---FPGMTGPVDAAFRNHNENRalehqrTYLFKGSLVW 124
Cdd:cd00094     2 DACDPLSFDAVTTLR-GELYFFKGRYFWRLSPGkPPGSPFLIssfWPSLPSPVDAAFERPDTGK------IYFFKGDKYW 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113570075 125 SYFEGQLVMGYPRLIgQEFPGVP--DNLDAAVECHRgecrTDSILFFKGGHVYIYS------AQEEPPIKQRQWAALGS- 195
Cdd:cd00094    75 VYTGKNLEPGYPKPI-SDLGFPPtvKQIDAALRWPD----NGKTYFFKGDKYWRYDektqkmDPGYPKLIETDFPGVPDk 149
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2113570075 196 CTATVRWL-GRYYCFNDIYFTRFDPVSGQVLSPRPLDARDYFVRC 239
Cdd:cd00094   150 VDAAFRWLdGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
259-448 2.26e-28

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 110.86  E-value: 2.26e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113570075 259 DRCSKRSFEAFSSDDKSWtYAYRGGWFFRLDASKDGWHAWPLSHTWKNLQGTVDAVFNHENR--MYFIQGSQVIVYISDQ 336
Cdd:cd00094     2 DACDPLSFDAVTTLRGEL-YFFKGRYFWRLSPGKPPGSPFLISSFWPSLPSPVDAAFERPDTgkIYFFKGDKYWVYTGKN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113570075 337 MyipVLGYPKPIQEEWEVSGVTAVDAAFTCPHSSDLYLLRGNKLILVDLNTR-------KRSGEDRTIIHADVDSAMCNT 409
Cdd:cd00094    81 L---EPGYPKPISDLGFPPTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQkmdpgypKLIETDFPGVPDKVDAAFRWL 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2113570075 410 HG-LYLFHGQSFYHYKNVEELLSSkvaPAPGNIASYFMDC 448
Cdd:cd00094   158 DGyYYFFKGDQYWRFDPRSKEVRV---GYPLKISSDWLGC 194
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
97-147 1.15e-06

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 44.93  E-value: 1.15e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2113570075   97 VDAAFRNHNEnralehqRTYLFKGSLVWSYFEGQLVMGYPRLIGQEFPGVP 147
Cdd:smart00120   1 IDAAFELRDG-------KTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLP 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
97-147 1.88e-05

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 41.78  E-value: 1.88e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2113570075  97 VDAAFRnhnenraLEHQRTYLFKGSLVWSYFEGQLVMGYPRLIGqEFPGVP 147
Cdd:pfam00045   1 IDAAFE-------DRDGKTYFFKGRKYWRFDPQRVEPGYPKLIS-DFPGLP 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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