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Conserved domains on  [gi|2124388297|ref|XP_044560148|]
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uncharacterized protein FDP41_005429 [Naegleria fowleri]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCC2 cd23958
Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid ...
 308-1548 0e+00

Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid cohesion protein 2 (Scc2) and its homolog (Scc2 homolog, also called Nipped-B-like protein or NIPBL). Scc2/NIPBL and Scc4 form a complex that is responsible for loading the cohesin protein onto sister chromatids during mitosis and meiosis. Cohesin is a ring-shaped protein complex that encircles the sister chromatids and helps to hold them together until they are ready to be separated during cell division. In addition to its role in chromosome segregation, cohesin also plays important roles in other cellular processes such as transcription, chromosome condensation, and DNA repair.


:

Pssm-ID: 467937 [Multi-domain]  Cd Length: 1197  Bit Score: 811.14  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  308 KLTKLLNVLESQVKIGLEMLKAVTETTkeELISSLKQDRESLNISCRCAILELTVMAGKGLSKEVLLEECFDTILDFSKT 387
Cdd:cd23958      1 KLVRLLTILERNIRDGESLDLDLDESQ--EDDEERLWLLERIDRALEAADASLTILTSPGLPKQLYSEDLIERVVDFLKF 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  388 ILRKYIYPIVESEDIL------------KKKSNKKFSCNSEIIHVCKIFKRLDKMLRKQKLKDEFILTISDIAVSTFFVN 455
Cdd:cd23958     79 QLENTIYPAYDPVYRSdssakagkkkraKASSKKKKSVSTLLNKLCELLSLLAELLSLQSLTDSVILQLVYLAISPFFVE 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  456 ----GIDEIQLSLLGVITKIFSSYAEHRDQILGEITVSLLRLPAHKKTDRRFRIAENsTYIQMFTSLMLQLIHSCTDVKN 531
Cdd:cd23958    159 navsNVDELQLSALKLLTSIFSRYPDQRQFIIEEILSSLAKLPSSKRNLRQFRLNDG-KSIQMVTALLLQLVQSSVKLPN 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  532 KETSIARKLVFGDEntdentsdnegedddiMKDDTPESEDSILESYEQAVRCATTFSEYFMERCT-KSESVDGDNRLIIE 610
Cdd:cd23958    238 LEKESSRDKSLEED----------------SDELLEDEESALAKSYESAVRIASYFLSFLLQKCTkKKKEKDTDYRPLFE 301

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  611 HFVEDLLVVLPLPSWPGADLLLQALANVLCNKYLSQKDVADkFRQLALKILGKIAARTKELEFKNsefmkeymltmgcve 690
Cdd:cd23958    302 NFVQDLLTVLNLPEWPAAELLLSLLGRLLVSIFSNKKTDAN-ARVMALDLLGLIAARLRKDALAE--------------- 365

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  691 ddeaekksqedhpfttpqkpksftesptqklqnefknlfqldevdKMKLSLFTYLCTQEKGEPMLAFAKQFIVCQWFYD- 769
Cdd:cd23958    366 ---------------------------------------------ELQKALLDYLAENSSSDPSLESARGFYLAQWLRDl 400

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  770 ------------EREIEKKAPFYKSL-----LSRDDSDISNSSIQASHAKDLYLnvICNRTSSVINKFDFVFGQIISELK 832
Cdd:cd23958    401 snelekaekaaeEEDTILKLELSELRkkfldSKILSKEEEASPLSREDAKLLYR--ALASQRPLSQSFDPILKQLLSSLD 478

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  833 DEKAKVRADAVKALQTVINIDSSVLMKNYVQMGIRERTLDEFPSVRECVIDLIGNAMITLKRFEDFYIRIILDRVKvDKA 912
Cdd:cd23958    479 EPAVTLRTKALKALSLVVEADPSILGDPDVQRAVEGRLLDSSASVREAAVELVGKYISSRPDLAEQYYEMIAERIL-DTG 557

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  913 KSVRKRSITILGDICTHITDDGTITEICKTLATRLSHqnkEEDNIKELVLKTFTKLWFDKNTS--------EKLKISGLQ 984
Cdd:cd23958    558 VSVRKRVIKILRDIYLRTPDFEIKVDICVRLLRRIND---EEESIKDLARKTFQELWFTPFPEssspaqdkESLAERVLL 634

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  985 IVDVIGKQNidfkqYKDHWLYQIIKM---SSDSKEHEKIKKSLSMIIEPLLQHIIKLAGEplnLDVPNRSNIATCMAALH 1061
Cdd:cd23958    635 IVDVVAACR-----KGLDLLEQLLKRllkSKEDKEDKSVRKACKQLVDCLVELILELEED---DDESSESDLVACLSTLH 706

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1062 LICLADYSLLL-PHFKTVSVYANSGYPGP----VIFHAVSMIEKICPYINKPEPTYCTKLQKELLQTIFSSQgikPETID 1136
Cdd:cd23958    707 LFAKADPKLLLvEHAETLQPYLKSKCSTRedqqVLRYVLRILRSVLPLLSHPSESFLEELEEDLLKLLLKHS---VTVLQ 783

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1137 ACIGCLCAFLRRTKNS--------QEIYKILTRIVHLMAVNETNLQNDATTARLIYAAALFCRYHDVDTITDIPENVihP 1208
Cdd:cd23958    784 EAIACLCAVVNKLTKNyerlrkalQSCLKLLRKYKRQANLDPSSLKEDPKLLRLLYILGLLARYCDFDSERDDFEKA--P 861

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1209 NLKPGSVATTIYSIIIGWMSQGTNL-LKQKAARSIGFLLIRQPKLFLLKQSQKIISECLNSPNKELVIQVVLMFKDFLLA 1287
Cdd:cd23958    862 LKTKESVKELVFDLLLFFTKPPIDEdVRKKALQALGFLCIAHPKLFLSPEVLKLLDEILASGSLKLKLQVLRNLQEFLQA 941

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1288 EESKLSAAGNQD------------------NVDAGVTSTLMSSYIDSIIALLDDPTDVIRLATLEVLDLTVQQGLTIPSR 1349
Cdd:cd23958    942 EEKRMEAADAEWkknskaadvkvldgkemgDADSGVASSIMQRYLKDILELCLSSDSQVRLAALKVLELILRQGLVHPIQ 1021

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1350 IMKFIIAMECDPNIEIREKAHTLNLYLYDRFAKAFIGEQRHGFLLSYSHLQKINEGTVVVRGvsaaaSSNDETHSVFKGA 1429
Cdd:cd23958   1022 CVPTLIALETDPNPAIRKLALRLLKELHEKYESLVESKYLEGVRLAFQYQKRLAGDTRGRGF-----RTDSPPTALLGRL 1096

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1430 YSFVGDfPAETKKNIMCDVVKSIFNLLETSADNLALLNQVSFMIEALTFIQYKTLAEVAGMVCTIQEKLDTIGDSYCEEL 1509
Cdd:cd23958   1097 YSLLRG-NRKSRRKFLKSLLKLFDFDLKKSSDSPSDLDFLLFLAENLAFLPYQTQDEPLFVIHTIDRILSVTGSSLLQAI 1175

                         1290      1300      1310
                   ....*....|....*....|....*....|....*....
gi 2124388297 1510 ktqikkddknlklihknIALATSLCFLIQFKNTLKIRYN 1548
Cdd:cd23958   1176 -----------------AKASQALLLLLLLKQHLKRLYG 1197
 
Name Accession Description Interval E-value
SCC2 cd23958
Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid ...
 308-1548 0e+00

Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid cohesion protein 2 (Scc2) and its homolog (Scc2 homolog, also called Nipped-B-like protein or NIPBL). Scc2/NIPBL and Scc4 form a complex that is responsible for loading the cohesin protein onto sister chromatids during mitosis and meiosis. Cohesin is a ring-shaped protein complex that encircles the sister chromatids and helps to hold them together until they are ready to be separated during cell division. In addition to its role in chromosome segregation, cohesin also plays important roles in other cellular processes such as transcription, chromosome condensation, and DNA repair.


Pssm-ID: 467937 [Multi-domain]  Cd Length: 1197  Bit Score: 811.14  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  308 KLTKLLNVLESQVKIGLEMLKAVTETTkeELISSLKQDRESLNISCRCAILELTVMAGKGLSKEVLLEECFDTILDFSKT 387
Cdd:cd23958      1 KLVRLLTILERNIRDGESLDLDLDESQ--EDDEERLWLLERIDRALEAADASLTILTSPGLPKQLYSEDLIERVVDFLKF 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  388 ILRKYIYPIVESEDIL------------KKKSNKKFSCNSEIIHVCKIFKRLDKMLRKQKLKDEFILTISDIAVSTFFVN 455
Cdd:cd23958     79 QLENTIYPAYDPVYRSdssakagkkkraKASSKKKKSVSTLLNKLCELLSLLAELLSLQSLTDSVILQLVYLAISPFFVE 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  456 ----GIDEIQLSLLGVITKIFSSYAEHRDQILGEITVSLLRLPAHKKTDRRFRIAENsTYIQMFTSLMLQLIHSCTDVKN 531
Cdd:cd23958    159 navsNVDELQLSALKLLTSIFSRYPDQRQFIIEEILSSLAKLPSSKRNLRQFRLNDG-KSIQMVTALLLQLVQSSVKLPN 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  532 KETSIARKLVFGDEntdentsdnegedddiMKDDTPESEDSILESYEQAVRCATTFSEYFMERCT-KSESVDGDNRLIIE 610
Cdd:cd23958    238 LEKESSRDKSLEED----------------SDELLEDEESALAKSYESAVRIASYFLSFLLQKCTkKKKEKDTDYRPLFE 301

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  611 HFVEDLLVVLPLPSWPGADLLLQALANVLCNKYLSQKDVADkFRQLALKILGKIAARTKELEFKNsefmkeymltmgcve 690
Cdd:cd23958    302 NFVQDLLTVLNLPEWPAAELLLSLLGRLLVSIFSNKKTDAN-ARVMALDLLGLIAARLRKDALAE--------------- 365

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  691 ddeaekksqedhpfttpqkpksftesptqklqnefknlfqldevdKMKLSLFTYLCTQEKGEPMLAFAKQFIVCQWFYD- 769
Cdd:cd23958    366 ---------------------------------------------ELQKALLDYLAENSSSDPSLESARGFYLAQWLRDl 400

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  770 ------------EREIEKKAPFYKSL-----LSRDDSDISNSSIQASHAKDLYLnvICNRTSSVINKFDFVFGQIISELK 832
Cdd:cd23958    401 snelekaekaaeEEDTILKLELSELRkkfldSKILSKEEEASPLSREDAKLLYR--ALASQRPLSQSFDPILKQLLSSLD 478

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  833 DEKAKVRADAVKALQTVINIDSSVLMKNYVQMGIRERTLDEFPSVRECVIDLIGNAMITLKRFEDFYIRIILDRVKvDKA 912
Cdd:cd23958    479 EPAVTLRTKALKALSLVVEADPSILGDPDVQRAVEGRLLDSSASVREAAVELVGKYISSRPDLAEQYYEMIAERIL-DTG 557

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  913 KSVRKRSITILGDICTHITDDGTITEICKTLATRLSHqnkEEDNIKELVLKTFTKLWFDKNTS--------EKLKISGLQ 984
Cdd:cd23958    558 VSVRKRVIKILRDIYLRTPDFEIKVDICVRLLRRIND---EEESIKDLARKTFQELWFTPFPEssspaqdkESLAERVLL 634

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  985 IVDVIGKQNidfkqYKDHWLYQIIKM---SSDSKEHEKIKKSLSMIIEPLLQHIIKLAGEplnLDVPNRSNIATCMAALH 1061
Cdd:cd23958    635 IVDVVAACR-----KGLDLLEQLLKRllkSKEDKEDKSVRKACKQLVDCLVELILELEED---DDESSESDLVACLSTLH 706

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1062 LICLADYSLLL-PHFKTVSVYANSGYPGP----VIFHAVSMIEKICPYINKPEPTYCTKLQKELLQTIFSSQgikPETID 1136
Cdd:cd23958    707 LFAKADPKLLLvEHAETLQPYLKSKCSTRedqqVLRYVLRILRSVLPLLSHPSESFLEELEEDLLKLLLKHS---VTVLQ 783

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1137 ACIGCLCAFLRRTKNS--------QEIYKILTRIVHLMAVNETNLQNDATTARLIYAAALFCRYHDVDTITDIPENVihP 1208
Cdd:cd23958    784 EAIACLCAVVNKLTKNyerlrkalQSCLKLLRKYKRQANLDPSSLKEDPKLLRLLYILGLLARYCDFDSERDDFEKA--P 861

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1209 NLKPGSVATTIYSIIIGWMSQGTNL-LKQKAARSIGFLLIRQPKLFLLKQSQKIISECLNSPNKELVIQVVLMFKDFLLA 1287
Cdd:cd23958    862 LKTKESVKELVFDLLLFFTKPPIDEdVRKKALQALGFLCIAHPKLFLSPEVLKLLDEILASGSLKLKLQVLRNLQEFLQA 941

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1288 EESKLSAAGNQD------------------NVDAGVTSTLMSSYIDSIIALLDDPTDVIRLATLEVLDLTVQQGLTIPSR 1349
Cdd:cd23958    942 EEKRMEAADAEWkknskaadvkvldgkemgDADSGVASSIMQRYLKDILELCLSSDSQVRLAALKVLELILRQGLVHPIQ 1021

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1350 IMKFIIAMECDPNIEIREKAHTLNLYLYDRFAKAFIGEQRHGFLLSYSHLQKINEGTVVVRGvsaaaSSNDETHSVFKGA 1429
Cdd:cd23958   1022 CVPTLIALETDPNPAIRKLALRLLKELHEKYESLVESKYLEGVRLAFQYQKRLAGDTRGRGF-----RTDSPPTALLGRL 1096

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1430 YSFVGDfPAETKKNIMCDVVKSIFNLLETSADNLALLNQVSFMIEALTFIQYKTLAEVAGMVCTIQEKLDTIGDSYCEEL 1509
Cdd:cd23958   1097 YSLLRG-NRKSRRKFLKSLLKLFDFDLKKSSDSPSDLDFLLFLAENLAFLPYQTQDEPLFVIHTIDRILSVTGSSLLQAI 1175

                         1290      1300      1310
                   ....*....|....*....|....*....|....*....
gi 2124388297 1510 ktqikkddknlklihknIALATSLCFLIQFKNTLKIRYN 1548
Cdd:cd23958   1176 -----------------AKASQALLLLLLLKQHLKRLYG 1197
Nipped-B_C pfam12830
Sister chromatid cohesion C-terminus; This domain lies towards the C-terminus of nipped-B or ...
 1307-1487 1.10e-18

Sister chromatid cohesion C-terminus; This domain lies towards the C-terminus of nipped-B or sister chromatid cohesion proteins.


Pssm-ID: 463722  Cd Length: 180  Bit Score: 85.28  E-value: 1.10e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1307 STLMSSYIDSIIALLDDPTDVIRLATLEVLDLTVQQGLTIPSRIMKFIIAMECDPNIEIREKAHTLNLYLYDRFAKAFIG 1386
Cdd:pfam12830    2 SALVQRYLKHILEICLSSDDQVRLLALEVLALILRQGLVHPKECIPTLIALETSPNPYIRKLAFELHKELHEKHESLLES 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1387 EQRHGFLLSYSHLQKINEGtvvvrgvsaaaSSNDETHSVFKGAYSFVGdfpaETKKN---IMCDVVKSIFNLLETSADNL 1463
Cdd:pfam12830   82 RYMEGIRLAFEYQRRVLSG-----------ATLEPPTSFLSLLYSLLR----SNKKSrkkFLKSLVKLFFDLDLSSESSP 146

                          170       180
                   ....*....|....*....|....
gi 2124388297 1464 ALLNQVSFMIEALTFIQYKTLAEV 1487
Cdd:pfam12830  147 SDLDFLRFLAENLAFLPYQTQDEV 170
 
Name Accession Description Interval E-value
SCC2 cd23958
Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid ...
 308-1548 0e+00

Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid cohesion protein 2 (Scc2) and its homolog (Scc2 homolog, also called Nipped-B-like protein or NIPBL). Scc2/NIPBL and Scc4 form a complex that is responsible for loading the cohesin protein onto sister chromatids during mitosis and meiosis. Cohesin is a ring-shaped protein complex that encircles the sister chromatids and helps to hold them together until they are ready to be separated during cell division. In addition to its role in chromosome segregation, cohesin also plays important roles in other cellular processes such as transcription, chromosome condensation, and DNA repair.


Pssm-ID: 467937 [Multi-domain]  Cd Length: 1197  Bit Score: 811.14  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  308 KLTKLLNVLESQVKIGLEMLKAVTETTkeELISSLKQDRESLNISCRCAILELTVMAGKGLSKEVLLEECFDTILDFSKT 387
Cdd:cd23958      1 KLVRLLTILERNIRDGESLDLDLDESQ--EDDEERLWLLERIDRALEAADASLTILTSPGLPKQLYSEDLIERVVDFLKF 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  388 ILRKYIYPIVESEDIL------------KKKSNKKFSCNSEIIHVCKIFKRLDKMLRKQKLKDEFILTISDIAVSTFFVN 455
Cdd:cd23958     79 QLENTIYPAYDPVYRSdssakagkkkraKASSKKKKSVSTLLNKLCELLSLLAELLSLQSLTDSVILQLVYLAISPFFVE 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  456 ----GIDEIQLSLLGVITKIFSSYAEHRDQILGEITVSLLRLPAHKKTDRRFRIAENsTYIQMFTSLMLQLIHSCTDVKN 531
Cdd:cd23958    159 navsNVDELQLSALKLLTSIFSRYPDQRQFIIEEILSSLAKLPSSKRNLRQFRLNDG-KSIQMVTALLLQLVQSSVKLPN 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  532 KETSIARKLVFGDEntdentsdnegedddiMKDDTPESEDSILESYEQAVRCATTFSEYFMERCT-KSESVDGDNRLIIE 610
Cdd:cd23958    238 LEKESSRDKSLEED----------------SDELLEDEESALAKSYESAVRIASYFLSFLLQKCTkKKKEKDTDYRPLFE 301

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  611 HFVEDLLVVLPLPSWPGADLLLQALANVLCNKYLSQKDVADkFRQLALKILGKIAARTKELEFKNsefmkeymltmgcve 690
Cdd:cd23958    302 NFVQDLLTVLNLPEWPAAELLLSLLGRLLVSIFSNKKTDAN-ARVMALDLLGLIAARLRKDALAE--------------- 365

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  691 ddeaekksqedhpfttpqkpksftesptqklqnefknlfqldevdKMKLSLFTYLCTQEKGEPMLAFAKQFIVCQWFYD- 769
Cdd:cd23958    366 ---------------------------------------------ELQKALLDYLAENSSSDPSLESARGFYLAQWLRDl 400

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  770 ------------EREIEKKAPFYKSL-----LSRDDSDISNSSIQASHAKDLYLnvICNRTSSVINKFDFVFGQIISELK 832
Cdd:cd23958    401 snelekaekaaeEEDTILKLELSELRkkfldSKILSKEEEASPLSREDAKLLYR--ALASQRPLSQSFDPILKQLLSSLD 478

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  833 DEKAKVRADAVKALQTVINIDSSVLMKNYVQMGIRERTLDEFPSVRECVIDLIGNAMITLKRFEDFYIRIILDRVKvDKA 912
Cdd:cd23958    479 EPAVTLRTKALKALSLVVEADPSILGDPDVQRAVEGRLLDSSASVREAAVELVGKYISSRPDLAEQYYEMIAERIL-DTG 557

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  913 KSVRKRSITILGDICTHITDDGTITEICKTLATRLSHqnkEEDNIKELVLKTFTKLWFDKNTS--------EKLKISGLQ 984
Cdd:cd23958    558 VSVRKRVIKILRDIYLRTPDFEIKVDICVRLLRRIND---EEESIKDLARKTFQELWFTPFPEssspaqdkESLAERVLL 634

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297  985 IVDVIGKQNidfkqYKDHWLYQIIKM---SSDSKEHEKIKKSLSMIIEPLLQHIIKLAGEplnLDVPNRSNIATCMAALH 1061
Cdd:cd23958    635 IVDVVAACR-----KGLDLLEQLLKRllkSKEDKEDKSVRKACKQLVDCLVELILELEED---DDESSESDLVACLSTLH 706

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1062 LICLADYSLLL-PHFKTVSVYANSGYPGP----VIFHAVSMIEKICPYINKPEPTYCTKLQKELLQTIFSSQgikPETID 1136
Cdd:cd23958    707 LFAKADPKLLLvEHAETLQPYLKSKCSTRedqqVLRYVLRILRSVLPLLSHPSESFLEELEEDLLKLLLKHS---VTVLQ 783

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1137 ACIGCLCAFLRRTKNS--------QEIYKILTRIVHLMAVNETNLQNDATTARLIYAAALFCRYHDVDTITDIPENVihP 1208
Cdd:cd23958    784 EAIACLCAVVNKLTKNyerlrkalQSCLKLLRKYKRQANLDPSSLKEDPKLLRLLYILGLLARYCDFDSERDDFEKA--P 861

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1209 NLKPGSVATTIYSIIIGWMSQGTNL-LKQKAARSIGFLLIRQPKLFLLKQSQKIISECLNSPNKELVIQVVLMFKDFLLA 1287
Cdd:cd23958    862 LKTKESVKELVFDLLLFFTKPPIDEdVRKKALQALGFLCIAHPKLFLSPEVLKLLDEILASGSLKLKLQVLRNLQEFLQA 941

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1288 EESKLSAAGNQD------------------NVDAGVTSTLMSSYIDSIIALLDDPTDVIRLATLEVLDLTVQQGLTIPSR 1349
Cdd:cd23958    942 EEKRMEAADAEWkknskaadvkvldgkemgDADSGVASSIMQRYLKDILELCLSSDSQVRLAALKVLELILRQGLVHPIQ 1021

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1350 IMKFIIAMECDPNIEIREKAHTLNLYLYDRFAKAFIGEQRHGFLLSYSHLQKINEGTVVVRGvsaaaSSNDETHSVFKGA 1429
Cdd:cd23958   1022 CVPTLIALETDPNPAIRKLALRLLKELHEKYESLVESKYLEGVRLAFQYQKRLAGDTRGRGF-----RTDSPPTALLGRL 1096

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1430 YSFVGDfPAETKKNIMCDVVKSIFNLLETSADNLALLNQVSFMIEALTFIQYKTLAEVAGMVCTIQEKLDTIGDSYCEEL 1509
Cdd:cd23958   1097 YSLLRG-NRKSRRKFLKSLLKLFDFDLKKSSDSPSDLDFLLFLAENLAFLPYQTQDEPLFVIHTIDRILSVTGSSLLQAI 1175

                         1290      1300      1310
                   ....*....|....*....|....*....|....*....
gi 2124388297 1510 ktqikkddknlklihknIALATSLCFLIQFKNTLKIRYN 1548
Cdd:cd23958   1176 -----------------AKASQALLLLLLLKQHLKRLYG 1197
Nipped-B_C pfam12830
Sister chromatid cohesion C-terminus; This domain lies towards the C-terminus of nipped-B or ...
 1307-1487 1.10e-18

Sister chromatid cohesion C-terminus; This domain lies towards the C-terminus of nipped-B or sister chromatid cohesion proteins.


Pssm-ID: 463722  Cd Length: 180  Bit Score: 85.28  E-value: 1.10e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1307 STLMSSYIDSIIALLDDPTDVIRLATLEVLDLTVQQGLTIPSRIMKFIIAMECDPNIEIREKAHTLNLYLYDRFAKAFIG 1386
Cdd:pfam12830    2 SALVQRYLKHILEICLSSDDQVRLLALEVLALILRQGLVHPKECIPTLIALETSPNPYIRKLAFELHKELHEKHESLLES 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124388297 1387 EQRHGFLLSYSHLQKINEGtvvvrgvsaaaSSNDETHSVFKGAYSFVGdfpaETKKN---IMCDVVKSIFNLLETSADNL 1463
Cdd:pfam12830   82 RYMEGIRLAFEYQRRVLSG-----------ATLEPPTSFLSLLYSLLR----SNKKSrkkFLKSLVKLFFDLDLSSESSP 146

                          170       180
                   ....*....|....*....|....
gi 2124388297 1464 ALLNQVSFMIEALTFIQYKTLAEV 1487
Cdd:pfam12830  147 SDLDFLRFLAENLAFLPYQTQDEV 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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