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Conserved domains on  [gi|2201699194|ref|XP_046761187|]
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prolactin receptor isoform X1 [Gallus gallus]

Protein Classification

FN3 domain-containing protein( domain architecture ID 10414134)

FN3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 227-323 1.66e-33

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09067:

Pssm-ID: 473895  Cd Length: 104  Bit Score: 124.07  E-value: 1.66e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 227 GQSPPEKPTIIKCRSPEKETFTCWWKPGLDGGHPTNYTLLYSKEGeEQVYECPDYRTAGPNS-----CYFDKKHTSFWTI 301
Cdd:pfam09067   4 ALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYEN-ETVKECPLYSTSGANStrlfiCFFPKNDVSLFVP 82

                          90       100
                  ....*....|....*....|..
gi 2201699194 302 YNITVRATNEMGSNSSDPHYVD 323
Cdd:pfam09067  83 LHITVVATNTNGTRYSRELSVE 104
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 23-120 1.07e-30

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09067:

Pssm-ID: 473895  Cd Length: 104  Bit Score: 116.37  E-value: 1.07e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194  23 AGQSFPGKPKIIRCRSLEKETFSCWWKPGSDGGLPTNYTLFYSKDSeEEIYECPDYRTSGPNS-----CYFNKNHTSPWT 97
Cdd:pfam09067   3 AALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYEN-ETVKECPLYSTSGANStrlfiCFFPKNDVSLFV 81

                          90       100
                  ....*....|....*....|...
gi 2201699194  98 TFNITVTATNEIGSNSSDPQYVD 120
Cdd:pfam09067  82 PLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 127-222 2.95e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.81  E-value: 2.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 127 PGSPVNLTLE--TKRSANImylwaKWSPPllADANSNHLyHYELRIKPEEKEEWETISVGV--QTQCKINRLNAGMRYVV 202
Cdd:cd00063     1 PSPPTNLRVTdvTSTSVTL-----SWTPP--EDDGGPIT-GYVVEYREKGSGDWKEVEVTPgsETSYTLTGLKPGTEYEF 72

                          90       100
                  ....*....|....*....|
gi 2201699194 203 QVRCTLDPGeWSEWSSERHI 222
Cdd:cd00063    73 RVRAVNGGG-ESPPSESVTV 91
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 330-425 4.71e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 4.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 330 PDPPVNVTLElkkpINRKPYLVLTWSPPPladvRSGWLTLEYELRLKPEEGEEWETI--FVGQQTQYKMFSLNPGKKYII 407
Cdd:cd00063     1 PSPPTNLRVT----DVTSTSVTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEF 72

                          90
                  ....*....|....*...
gi 2201699194 408 QIHCKPDhhGSWSEWSSE 425
Cdd:cd00063    73 RVRAVNG--GGESPPSES 88
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 227-323 1.66e-33

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 124.07  E-value: 1.66e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 227 GQSPPEKPTIIKCRSPEKETFTCWWKPGLDGGHPTNYTLLYSKEGeEQVYECPDYRTAGPNS-----CYFDKKHTSFWTI 301
Cdd:pfam09067   4 ALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYEN-ETVKECPLYSTSGANStrlfiCFFPKNDVSLFVP 82

                          90       100
                  ....*....|....*....|..
gi 2201699194 302 YNITVRATNEMGSNSSDPHYVD 323
Cdd:pfam09067  83 LHITVVATNTNGTRYSRELSVE 104
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 23-120 1.07e-30

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 116.37  E-value: 1.07e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194  23 AGQSFPGKPKIIRCRSLEKETFSCWWKPGSDGGLPTNYTLFYSKDSeEEIYECPDYRTSGPNS-----CYFNKNHTSPWT 97
Cdd:pfam09067   3 AALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYEN-ETVKECPLYSTSGANStrlfiCFFPKNDVSLFV 81

                          90       100
                  ....*....|....*....|...
gi 2201699194  98 TFNITVTATNEIGSNSSDPQYVD 120
Cdd:pfam09067  82 PLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 127-222 2.95e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.81  E-value: 2.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 127 PGSPVNLTLE--TKRSANImylwaKWSPPllADANSNHLyHYELRIKPEEKEEWETISVGV--QTQCKINRLNAGMRYVV 202
Cdd:cd00063     1 PSPPTNLRVTdvTSTSVTL-----SWTPP--EDDGGPIT-GYVVEYREKGSGDWKEVEVTPgsETSYTLTGLKPGTEYEF 72

                          90       100
                  ....*....|....*....|
gi 2201699194 203 QVRCTLDPGeWSEWSSERHI 222
Cdd:cd00063    73 RVRAVNGGG-ESPPSESVTV 91
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
94-325 6.58e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 59.25  E-value: 6.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194  94 SPWTTFNITVTATNEIGSNSSDPQYVDVTSIVQPGSPVNLT--LETKRSANImylwaKWSPPLLADANSnhlyhYELRIK 171
Cdd:COG3401   200 EPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTatADTPGSVTL-----SWDPVTESDATG-----YRVYRS 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 172 PEEKEEWETISVGVQTQCKINRLNAGMRYVVQVRCTLDPGEWSEWSSErhILIPSGQSPPEKPTIIKCRSPEKETFTCWW 251
Cdd:COG3401   270 NSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNV--VSVTTDLTPPAAPSGLTATAVGSSSITLSW 347

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2201699194 252 KPGlDGGHPTNYTLLYSKEGE---EQVYEcpdyrTAGPNScYFDKKHTSFwTIYNITVRATNEMGSNSSDPHYVDVT 325
Cdd:COG3401   348 TAS-SDADVTGYNVYRSTSGGgtyTKIAE-----TVTTTS-YTDTGLTPG-TTYYYKVTAVDAAGNESAPSEEVSAT 416
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 330-425 4.71e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 4.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 330 PDPPVNVTLElkkpINRKPYLVLTWSPPPladvRSGWLTLEYELRLKPEEGEEWETI--FVGQQTQYKMFSLNPGKKYII 407
Cdd:cd00063     1 PSPPTNLRVT----DVTSTSVTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEF 72

                          90
                  ....*....|....*...
gi 2201699194 408 QIHCKPDhhGSWSEWSSE 425
Cdd:cd00063    73 RVRAVNG--GGESPPSES 88
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
300-425 1.59e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.54  E-value: 1.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 300 TIYNITVRATNEMGSNSSDPHYVDVTYIVQPDPPVNVTLELKKPinrkPYLVLTWSPPPLADVRSgwltleYELRLKPEE 379
Cdd:COG3401   203 TTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTP----GSVTLSWDPVTESDATG------YRVYRSNSG 272

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2201699194 380 GEEWETIFVGQQTQYKMFSLNPGKKYIIQIHCKpDHHGSWSEWSSE 425
Cdd:COG3401   273 DGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAV-DAAGNESAPSNV 317
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 127-212 1.92e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.45  E-value: 1.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194  127 PGSPVNLTLE--TKRSANImylwaKWSPPLLADANSNHLYhYELRIKPEEKEEWETISVGVQTQCKINRLNAGMRYVVQV 204
Cdd:smart00060   1 PSPPSNLRVTdvTSTSVTL-----SWEPPPDDGITGYIVG-YRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                   ....*...
gi 2201699194  205 RCTLDPGE 212
Cdd:smart00060  75 RAVNGAGE 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 330-418 4.71e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 4.71e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194  330 PDPPVNVTLElkkpINRKPYLVLTWSPPPLADVRSgwLTLEYELRLKPEEGEEWETIFVGQQTQYKMFSLNPGKKYIIQI 409
Cdd:smart00060   1 PSPPSNLRVT----DVTSTSVTLSWEPPPDDGITG--YIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                   ....*....
gi 2201699194  410 HCKPDHHGS 418
Cdd:smart00060  75 RAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 28-119 5.30e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.57  E-value: 5.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194  28 PGKPKIIRCRSLEKETFSCWWK-PGSDGGLPTNYTLFYSKDSEEEIYECPdyrTSGPNSCYFNKNHTSPWTTFNITVTAT 106
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTpPEDDGGPITGYVVEYREKGSGDWKEVE---VTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....
gi 2201699194 107 NEIG-SNSSDPQYV 119
Cdd:cd00063    78 NGGGeSPPSESVTV 91
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 231-322 6.07e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 6.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 231 PEKPTIIKCRSPEKETFTCWWK-PGLDGGHPTNYTLLYSKEGEEQVYECPdyrTAGPNSCYFDKKHTSFWTIYNITVRAT 309
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTpPEDDGGPITGYVVEYREKGSGDWKEVE---VTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....
gi 2201699194 310 NEMG-SNSSDPHYV 322
Cdd:cd00063    78 NGGGeSPPSESVTV 91
fn3 pfam00041
Fibronectin type III domain;
331-423 1.17e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 331 DPPVNVTLelkKPINRKpYLVLTWSPPPladVRSGWLTlEYELRLKPE-EGEEWETIFV-GQQTQYKMFSLNPGKKYIIQ 408
Cdd:pfam00041   1 SAPSNLTV---TDVTST-SLTVSWTPPP---DGNGPIT-GYEVEYRPKnSGEPWNEITVpGTTTSVTLTGLKPGTEYEVR 72

                          90
                  ....*....|....*
gi 2201699194 409 IHCKPDhhGSWSEWS 423
Cdd:pfam00041  73 VQAVNG--GGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
128-217 1.58e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.16  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 128 GSPVNLTLE--TKRSANImylwaKWSPPllaDANSNHLYHYELRIKPEEKEEW--ETISVGVQTQCKINRLNAGMRYVVQ 203
Cdd:pfam00041   1 SAPSNLTVTdvTSTSLTV-----SWTPP---PDGNGPITGYEVEYRPKNSGEPwnEITVPGTTTSVTLTGLKPGTEYEVR 72

                          90
                  ....*....|....
gi 2201699194 204 VRcTLDPGEWSEWS 217
Cdd:pfam00041  73 VQ-AVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 231-314 3.97e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.21  E-value: 3.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194  231 PEKPTIIKCRSPEKETFTCWWKPGLDGGHpTNYTLLYSKEGEEqVYECPDYRTAGPNSCYFDKKHTSFWTIYNITVRATN 310
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI-TGYIVGYRVEYRE-EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                   ....
gi 2201699194  311 EMGS 314
Cdd:smart00060  79 GAGE 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 28-111 6.36e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.44  E-value: 6.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194   28 PGKPKIIRCRSLEKETFSCWWKPGSDGGlPTNYTLFYSKDSEEEIYECPDYRTSgPNSCYFNKNHTSPWTTFNITVTATN 107
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDG-ITGYIVGYRVEYREEGSEWKEVNVT-PSSTSYTLTGLKPGTEYEFRVRAVN 78


                   ....
gi 2201699194  108 EIGS 111
Cdd:smart00060  79 GAGE 82
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 227-323 1.66e-33

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 124.07  E-value: 1.66e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 227 GQSPPEKPTIIKCRSPEKETFTCWWKPGLDGGHPTNYTLLYSKEGeEQVYECPDYRTAGPNS-----CYFDKKHTSFWTI 301
Cdd:pfam09067   4 ALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYEN-ETVKECPLYSTSGANStrlfiCFFPKNDVSLFVP 82

                          90       100
                  ....*....|....*....|..
gi 2201699194 302 YNITVRATNEMGSNSSDPHYVD 323
Cdd:pfam09067  83 LHITVVATNTNGTRYSRELSVE 104
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 23-120 1.07e-30

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 116.37  E-value: 1.07e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194  23 AGQSFPGKPKIIRCRSLEKETFSCWWKPGSDGGLPTNYTLFYSKDSeEEIYECPDYRTSGPNS-----CYFNKNHTSPWT 97
Cdd:pfam09067   3 AALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYEN-ETVKECPLYSTSGANStrlfiCFFPKNDVSLFV 81

                          90       100
                  ....*....|....*....|...
gi 2201699194  98 TFNITVTATNEIGSNSSDPQYVD 120
Cdd:pfam09067  82 PLHITVVATNTNGTRYSRELSVE 104
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 45-124 2.14e-09

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 55.11  E-value: 2.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194  45 SCWWKPGSDGGLPTNYTLFYSKDSEEEIYECPDY-RTSGPN-SCYFNKN--HTSPWTTFNITVTATNEIGSNSSDPQYVD 120
Cdd:pfam09240  13 SCEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYYiRDDGTRiGCQFDDLegLSSSFHQVYICVNGSSSAGPIRSSDQTFQ 92


                  ....
gi 2201699194 121 VTSI 124
Cdd:pfam09240  93 LQNI 96
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 127-222 2.95e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.81  E-value: 2.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 127 PGSPVNLTLE--TKRSANImylwaKWSPPllADANSNHLyHYELRIKPEEKEEWETISVGV--QTQCKINRLNAGMRYVV 202
Cdd:cd00063     1 PSPPTNLRVTdvTSTSVTL-----SWTPP--EDDGGPIT-GYVVEYREKGSGDWKEVEVTPgsETSYTLTGLKPGTEYEF 72

                          90       100
                  ....*....|....*....|
gi 2201699194 203 QVRCTLDPGeWSEWSSERHI 222
Cdd:cd00063    73 RVRAVNGGG-ESPPSESVTV 91
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
94-325 6.58e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 59.25  E-value: 6.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194  94 SPWTTFNITVTATNEIGSNSSDPQYVDVTSIVQPGSPVNLT--LETKRSANImylwaKWSPPLLADANSnhlyhYELRIK 171
Cdd:COG3401   200 EPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTatADTPGSVTL-----SWDPVTESDATG-----YRVYRS 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 172 PEEKEEWETISVGVQTQCKINRLNAGMRYVVQVRCTLDPGEWSEWSSErhILIPSGQSPPEKPTIIKCRSPEKETFTCWW 251
Cdd:COG3401   270 NSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNV--VSVTTDLTPPAAPSGLTATAVGSSSITLSW 347

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2201699194 252 KPGlDGGHPTNYTLLYSKEGE---EQVYEcpdyrTAGPNScYFDKKHTSFwTIYNITVRATNEMGSNSSDPHYVDVT 325
Cdd:COG3401   348 TAS-SDADVTGYNVYRSTSGGgtyTKIAE-----TVTTTS-YTDTGLTPG-TTYYYKVTAVDAAGNESAPSEEVSAT 416
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 330-425 4.71e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 4.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 330 PDPPVNVTLElkkpINRKPYLVLTWSPPPladvRSGWLTLEYELRLKPEEGEEWETI--FVGQQTQYKMFSLNPGKKYII 407
Cdd:cd00063     1 PSPPTNLRVT----DVTSTSVTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEF 72

                          90
                  ....*....|....*...
gi 2201699194 408 QIHCKPDhhGSWSEWSSE 425
Cdd:cd00063    73 RVRAVNG--GGESPPSES 88
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
300-425 1.59e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.54  E-value: 1.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 300 TIYNITVRATNEMGSNSSDPHYVDVTYIVQPDPPVNVTLELKKPinrkPYLVLTWSPPPLADVRSgwltleYELRLKPEE 379
Cdd:COG3401   203 TTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTP----GSVTLSWDPVTESDATG------YRVYRSNSG 272

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2201699194 380 GEEWETIFVGQQTQYKMFSLNPGKKYIIQIHCKpDHHGSWSEWSSE 425
Cdd:COG3401   273 DGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAV-DAAGNESAPSNV 317
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 127-212 1.92e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.45  E-value: 1.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194  127 PGSPVNLTLE--TKRSANImylwaKWSPPLLADANSNHLYhYELRIKPEEKEEWETISVGVQTQCKINRLNAGMRYVVQV 204
Cdd:smart00060   1 PSPPSNLRVTdvTSTSVTL-----SWEPPPDDGITGYIVG-YRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                   ....*...
gi 2201699194  205 RCTLDPGE 212
Cdd:smart00060  75 RAVNGAGE 82
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 249-317 2.07e-06

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 46.63  E-value: 2.07e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2201699194 249 CWWKPGLDGGHPTNYTLLYSKEGEEQVYECPDY-RTAGPN-SCYFD--KKHTSFWTIYNITVRATNEMGSNSS 317
Cdd:pfam09240  14 CEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYYiRDDGTRiGCQFDdlEGLSSSFHQVYICVNGSSSAGPIRS 86
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 330-418 4.71e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 4.71e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194  330 PDPPVNVTLElkkpINRKPYLVLTWSPPPLADVRSgwLTLEYELRLKPEEGEEWETIFVGQQTQYKMFSLNPGKKYIIQI 409
Cdd:smart00060   1 PSPPSNLRVT----DVTSTSVTLSWEPPPDDGITG--YIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                   ....*....
gi 2201699194  410 HCKPDHHGS 418
Cdd:smart00060  75 RAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 28-119 5.30e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.57  E-value: 5.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194  28 PGKPKIIRCRSLEKETFSCWWK-PGSDGGLPTNYTLFYSKDSEEEIYECPdyrTSGPNSCYFNKNHTSPWTTFNITVTAT 106
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTpPEDDGGPITGYVVEYREKGSGDWKEVE---VTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....
gi 2201699194 107 NEIG-SNSSDPQYV 119
Cdd:cd00063    78 NGGGeSPPSESVTV 91
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 231-322 6.07e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 6.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 231 PEKPTIIKCRSPEKETFTCWWK-PGLDGGHPTNYTLLYSKEGEEQVYECPdyrTAGPNSCYFDKKHTSFWTIYNITVRAT 309
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTpPEDDGGPITGYVVEYREKGSGDWKEVE---VTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....
gi 2201699194 310 NEMG-SNSSDPHYV 322
Cdd:cd00063    78 NGGGeSPPSESVTV 91
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
192-425 1.53e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.46  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 192 NRLNAGMRYVVQVRCTlDPGEWSEWSSERHILIPSgqSPPEKPTIIKCRSPEKETFTCWWKPGLDGGhPTNYTLLYSKEG 271
Cdd:COG3401   197 GDIEPGTTYYYRVAAT-DTGGESAPSNEVSVTTPT--TPPSAPTGLTATADTPGSVTLSWDPVTESD-ATGYRVYRSNSG 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 272 EEQvYEcpdYRTAGPNSCYFDKKHTSfWTIYNITVRATNEMGSNSSDPHYVDVT-YIVQPDPPVNVTLElkKPINRKpyL 350
Cdd:COG3401   273 DGP-FT---KVATVTTTSYTDTGLTN-GTTYYYRVTAVDAAGNESAPSNVVSVTtDLTPPAAPSGLTAT--AVGSSS--I 343

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2201699194 351 VLTWSPPPLADVRSgwltleYELRLKPEEGEEWETI-FVGQQTQYKMFSLNPGKKYIIQIHCKpDHHGSWSEWSSE 425
Cdd:COG3401   344 TLSWTASSDADVTG------YNVYRSTSGGGTYTKIaETVTTTSYTDTGLTPGTTYYYKVTAV-DAAGNESAPSEE 412
fn3 pfam00041
Fibronectin type III domain;
331-423 1.17e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 331 DPPVNVTLelkKPINRKpYLVLTWSPPPladVRSGWLTlEYELRLKPE-EGEEWETIFV-GQQTQYKMFSLNPGKKYIIQ 408
Cdd:pfam00041   1 SAPSNLTV---TDVTST-SLTVSWTPPP---DGNGPIT-GYEVEYRPKnSGEPWNEITVpGTTTSVTLTGLKPGTEYEVR 72

                          90
                  ....*....|....*
gi 2201699194 409 IHCKPDhhGSWSEWS 423
Cdd:pfam00041  73 VQAVNG--GGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
128-217 1.58e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.16  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 128 GSPVNLTLE--TKRSANImylwaKWSPPllaDANSNHLYHYELRIKPEEKEEW--ETISVGVQTQCKINRLNAGMRYVVQ 203
Cdd:pfam00041   1 SAPSNLTVTdvTSTSLTV-----SWTPP---PDGNGPITGYEVEYRPKNSGEPwnEITVPGTTTSVTLTGLKPGTEYEVR 72

                          90
                  ....*....|....
gi 2201699194 204 VRcTLDPGEWSEWS 217
Cdd:pfam00041  73 VQ-AVNGGGEGPPS 85
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
302-405 3.79e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 41.08  E-value: 3.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194 302 YNITVRATNEMGSnSSDPHYVDVTYIVQ----PDPPVNVTLElkkPINRkpYLVLTWSPPPLADvrsgwlTLEYELRLKP 377
Cdd:COG4733   599 YEVRVRAINALGV-SSAWAASSETTVTGktapPPAPTGLTAT---GGLG--GITLSWSFPVDAD------TLRTEIRYST 666

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2201699194 378 eeGEEWET----IFVGQQTQYKMFSLNPGKKY 405
Cdd:COG4733   667 --TGDWASatvaQALYPGNTYTLAGLKAGQTY 696
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 231-314 3.97e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.21  E-value: 3.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194  231 PEKPTIIKCRSPEKETFTCWWKPGLDGGHpTNYTLLYSKEGEEqVYECPDYRTAGPNSCYFDKKHTSFWTIYNITVRATN 310
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI-TGYIVGYRVEYRE-EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                   ....
gi 2201699194  311 EMGS 314
Cdd:smart00060  79 GAGE 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 28-111 6.36e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.44  E-value: 6.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201699194   28 PGKPKIIRCRSLEKETFSCWWKPGSDGGlPTNYTLFYSKDSEEEIYECPDYRTSgPNSCYFNKNHTSPWTTFNITVTATN 107
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDG-ITGYIVGYRVEYREEGSEWKEVNVT-PSSTSYTLTGLKPGTEYEFRVRAVN 78


                   ....
gi 2201699194  108 EIGS 111
Cdd:smart00060  79 GAGE 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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