|
Name |
Accession |
Description |
Interval |
E-value |
| rad3 super family |
cl36704 |
DNA repair helicase (rad3); All proteins in this family for which funcitons are known are ... |
227-866 |
1.57e-154 |
|
DNA repair helicase (rad3); All proteins in this family for which funcitons are known are DNA-DNA helicases that funciton in the initiation of transcription and nucleotide excision repair as part of the TFIIH complex. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
The actual alignment was detected with superfamily member TIGR00604:
Pssm-ID: 273169 [Multi-domain] Cd Length: 705 Bit Score: 470.35 E-value: 1.57e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 227 VTKIYYCSRTHSQLSQFVHEVQK--SPFGK------DTRLVSLGSRQNLCVNEEVRRLGALQLINDRCTEMQKNKHEkks 298
Cdd:TIGR00604 60 VRKIIYASRTHSQLEQATEELRKlmSYRTPrigeesPVSGLSLASRKNLCLHPEVSKERQGKVVNGKCIKLTVSKIK--- 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 299 daevEGKKRRVSRTVCPFY-SYEQMQFLRDEVLVEVKDIEQLVTLGKETKACPYYGSRYAIPAAQLVVLPYQMLLHEATR 377
Cdd:TIGR00604 137 ----EQRTEKPNVESCEFYeNFDELREVEDLLLSEIMDIEDLVEYGELLGLCPYFATRKMLPFANIVLLPYQYLLDPKIR 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 378 SAAGIILKDQVVIIDEAHNLIDTITCIYSAEVSGSQLCCAHSQLLQYMERYRKRLKAKNLMYIKQILYLLErfvVMLGGN 457
Cdd:TIGR00604 213 SAVSIELKDSIVIFDEAHNLDNVCISSLSSNLSVRSLKRCSKEIAEYFEKIEERKEVDARKLLDELQKLVE---GLKQED 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 458 VNQNPSCQVVSQTGTELKSINDFLFQSQIDNINLFKVQRYCEKSLISRKLFGFVERYgnPAPVVKTNKENQKLAGLQNFL 537
Cdd:TIGR00604 290 LLTDEDIFLANPVLPKEVLPEAVPGNIRIAEIFLHKLSRYLEYLKDALKVLGVVSEL--PDAFLEHLKEKTFIDRPLRFC 367
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 538 MtlqqgSYKEGPLQSPPVeADSDQLRAASPLMHIEGFLSALTNANEDGRVILNRQGTIGQsSLKFLLLNPAVHFAKVVKE 617
Cdd:TIGR00604 368 S-----ERLSNLLRELEI-THPEDFSALVLLFTFATLVLTYTNGFLEGIEPYENKTVPNP-ILKFMCLDPSIALKPLFER 440
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 618 CRAVIIAGGTMQPVADFREQLlsyaGVDParIVEFSCGHVIPPENILPIILCSGPSNQQLEFTYQTRDLPQMMDETGRIL 697
Cdd:TIGR00604 441 VRSVILASGTLSPLDAFPRNL----GFNP--VSQDSPTHILKRENLLTLIVTRGSDQVPLSSTFEIRNDPSLVRNLGELL 514
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 698 CNLCNVVPGGVVCFFPSYDYEKQVYAHWEKTGLLTRLATKKKIFQEPKKANQVEQVLAEYAkcikrcgQAGGQMTGALLL 777
Cdd:TIGR00604 515 VEFSKIIPDGIVVFFPSYSYLENIVSTWKEMGILENIEKKKLIFVETKDAQETSDALERYK-------QAVSEGRGAVLL 587
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 778 SVVGGKMSEGINFSDDLGRCVIMVGMPYPNIKSPELQEKMTWLDKTMPRSASQApsrvLIENLCMKAVNQSIGRAIRHQK 857
Cdd:TIGR00604 588 SVAGGKVSEGIDFCDDLGRAVIMVGIPYEYTESRILLARLEFLRDQYPIRENQD----FYEFDAMRAVNQAIGRVIRHKD 663
|
....*....
gi 2201709883 858 DYASILLLD 866
Cdd:TIGR00604 664 DYGSIVLLD 672
|
|
| PTZ00121 super family |
cl31754 |
MAEBL; Provisional |
70-339 |
2.54e-04 |
|
MAEBL; Provisional
The actual alignment was detected with superfamily member PTZ00121:
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 45.13 E-value: 2.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 70 EKKKQEEEARLLAPEGSGQEEKQTLASGGLVCPNSRDASGepdwvtafVQKKEEQDLVHRLKEEQIRRKKRE-ERLEKIR 148
Cdd:PTZ00121 1487 EAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADE--------AKKAEEAKKADEAKKAEEKKKADElKKAEELK 1558
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 149 HNVQLKYAAKRKRSEED--------------ETKRLLQLSKEILSEGAGAAvpEQLDHNEEELILAEY--ESDEEKKvas 212
Cdd:PTZ00121 1559 KAEEKKKAEEAKKAEEDknmalrkaeeakkaEEARIEEVMKLYEEEKKMKA--EEAKKAEEAKIKAEElkKAEEEKK--- 1633
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 213 gleedddddleeehvtKIYYCSRTHSQLSQFVHEVQKSPFGKDTRLVSLGSRQnlcvnEEVRRlgalqlindRCTEMQKN 292
Cdd:PTZ00121 1634 ----------------KVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKA-----EEDKK---------KAEEAKKA 1683
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2201709883 293 KHEKKSDAEVEGKKRRVSRTVcpfysyEQMQFLRDEvlvEVKDIEQL 339
Cdd:PTZ00121 1684 EEDEKKAAEALKKEAEEAKKA------EELKKKEAE---EKKKAEEL 1721
|
|
| P-loop_NTPase super family |
cl38936 |
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ... |
27-68 |
1.75e-03 |
|
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.
The actual alignment was detected with superfamily member cd09708:
Pssm-ID: 476819 [Multi-domain] Cd Length: 632 Bit Score: 41.88 E-value: 1.75e-03
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 2201709883 27 QEQFMAALYAALEAGRIGIFESPTGTGKSLSLICGALSWLQD 68
Cdd:cd09708 2 QALFYRNCLTSLRQKRIGMLEASTGVGKTLAMIMAALTMLKE 43
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| rad3 |
TIGR00604 |
DNA repair helicase (rad3); All proteins in this family for which funcitons are known are ... |
227-866 |
1.57e-154 |
|
DNA repair helicase (rad3); All proteins in this family for which funcitons are known are DNA-DNA helicases that funciton in the initiation of transcription and nucleotide excision repair as part of the TFIIH complex. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273169 [Multi-domain] Cd Length: 705 Bit Score: 470.35 E-value: 1.57e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 227 VTKIYYCSRTHSQLSQFVHEVQK--SPFGK------DTRLVSLGSRQNLCVNEEVRRLGALQLINDRCTEMQKNKHEkks 298
Cdd:TIGR00604 60 VRKIIYASRTHSQLEQATEELRKlmSYRTPrigeesPVSGLSLASRKNLCLHPEVSKERQGKVVNGKCIKLTVSKIK--- 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 299 daevEGKKRRVSRTVCPFY-SYEQMQFLRDEVLVEVKDIEQLVTLGKETKACPYYGSRYAIPAAQLVVLPYQMLLHEATR 377
Cdd:TIGR00604 137 ----EQRTEKPNVESCEFYeNFDELREVEDLLLSEIMDIEDLVEYGELLGLCPYFATRKMLPFANIVLLPYQYLLDPKIR 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 378 SAAGIILKDQVVIIDEAHNLIDTITCIYSAEVSGSQLCCAHSQLLQYMERYRKRLKAKNLMYIKQILYLLErfvVMLGGN 457
Cdd:TIGR00604 213 SAVSIELKDSIVIFDEAHNLDNVCISSLSSNLSVRSLKRCSKEIAEYFEKIEERKEVDARKLLDELQKLVE---GLKQED 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 458 VNQNPSCQVVSQTGTELKSINDFLFQSQIDNINLFKVQRYCEKSLISRKLFGFVERYgnPAPVVKTNKENQKLAGLQNFL 537
Cdd:TIGR00604 290 LLTDEDIFLANPVLPKEVLPEAVPGNIRIAEIFLHKLSRYLEYLKDALKVLGVVSEL--PDAFLEHLKEKTFIDRPLRFC 367
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 538 MtlqqgSYKEGPLQSPPVeADSDQLRAASPLMHIEGFLSALTNANEDGRVILNRQGTIGQsSLKFLLLNPAVHFAKVVKE 617
Cdd:TIGR00604 368 S-----ERLSNLLRELEI-THPEDFSALVLLFTFATLVLTYTNGFLEGIEPYENKTVPNP-ILKFMCLDPSIALKPLFER 440
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 618 CRAVIIAGGTMQPVADFREQLlsyaGVDParIVEFSCGHVIPPENILPIILCSGPSNQQLEFTYQTRDLPQMMDETGRIL 697
Cdd:TIGR00604 441 VRSVILASGTLSPLDAFPRNL----GFNP--VSQDSPTHILKRENLLTLIVTRGSDQVPLSSTFEIRNDPSLVRNLGELL 514
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 698 CNLCNVVPGGVVCFFPSYDYEKQVYAHWEKTGLLTRLATKKKIFQEPKKANQVEQVLAEYAkcikrcgQAGGQMTGALLL 777
Cdd:TIGR00604 515 VEFSKIIPDGIVVFFPSYSYLENIVSTWKEMGILENIEKKKLIFVETKDAQETSDALERYK-------QAVSEGRGAVLL 587
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 778 SVVGGKMSEGINFSDDLGRCVIMVGMPYPNIKSPELQEKMTWLDKTMPRSASQApsrvLIENLCMKAVNQSIGRAIRHQK 857
Cdd:TIGR00604 588 SVAGGKVSEGIDFCDDLGRAVIMVGIPYEYTESRILLARLEFLRDQYPIRENQD----FYEFDAMRAVNQAIGRVIRHKD 663
|
....*....
gi 2201709883 858 DYASILLLD 866
Cdd:TIGR00604 664 DYGSIVLLD 672
|
|
| DEXDc2 |
smart00488 |
DEAD-like helicases superfamily; |
16-436 |
1.95e-85 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214693 [Multi-domain] Cd Length: 289 Bit Score: 275.03 E-value: 1.95e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 16 SFPFPYTPYRIQEQFMAALYAALEAGRIGIFESPTGTGKSLSLICGALSWLQDFEKKKQEeearllapegsgqeekqtla 95
Cdd:smart00488 2 LFYFPYEPYPIQYEFMEELKRVLDRGKIGILESPTGTGKTLSLLCLTLTWLRSFPERIQK-------------------- 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 96 sgglvcpnsrdasGEPDWVTAFVqkkeeqdlvhrlkeeqirrKKREERLEKIRHNVQLKyaakrkrseedetkrllqlsk 175
Cdd:smart00488 62 -------------IKLIYLSRTV-------------------SEIEKRLEELRKLMQKV--------------------- 88
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 176 eilsegagaavpeqldhneeelilaEYESDEEkkvasgleedddddleeehvtkiyycsrtHSQLSQFVHEVqkSPFGKD 255
Cdd:smart00488 89 -------------------------EYESDEE-----------------------------SEKQAQLLHEL--GREKPK 112
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 256 TRLVSLGSRQNLCVNEEVRRLGALQLIND-RCTEMQKNKHEKKsdaevegKKRRVSRTVCPFYSYEQMQFLRDEVLVEVK 334
Cdd:smart00488 113 VLGLSLTSRKNLCLNPEVRTLKQNGLVVDeVCRSLTASKARKY-------RYENPKVERCPFYENTEFLLVRDLLPAEVY 185
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 335 DIEQLVTLGKETKACPYYGSRYAIPAAQLVVLPYQMLLHEATRSAAGIILKDQVVIIDEAHNLIDTITCIYSAEVSGSQL 414
Cdd:smart00488 186 DIEDLLELGKRLGGCPYFASRKAIEFANVVVLPYQYLLDPKIRQALSIELKDSIVIFDEAHNLDNVCISALSSELSRRSL 265
|
410 420
....*....|....*....|....
gi 2201709883 415 CCAHSQLLQYMERYRK--RLKAKN 436
Cdd:smart00488 266 ERAHKNIKKYFERIEKirENDAKR 289
|
|
| SF2_C_XPD |
cd18788 |
C-terminal helicase domain of xeroderma pigmentosum group D (XPD) family DEAD-like helicases; ... |
661-867 |
6.06e-71 |
|
C-terminal helicase domain of xeroderma pigmentosum group D (XPD) family DEAD-like helicases; The xeroderma pigmentosum group D (XPD)-like family members are DEAD-box helicases belonging to superfamily (SF)2. This family includes DDX11 (also called ChlR1), a protein involved in maintaining chromosome transmission fidelity and genome stability, the TFIIH basal transcription factor complex XPD subunit, and FANCJ (also known as BRIP1), a DNA helicase required for the maintenance of chromosomal stability. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350175 [Multi-domain] Cd Length: 159 Bit Score: 230.95 E-value: 6.06e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 661 ENILPIILCSGPSNQQLEFTYQTRDLPQMMDETGRILCNLCNVVPGGVVCFFPSYDYEKQVYAhwektglltrlatkkki 740
Cdd:cd18788 1 DQVCPGIVGRGPDQQALNSKFQTREDEAVMDELGNLLLELCAVVPDGVLVFFPSYSYMERVVS----------------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 741 fqepkkanqveqvlaeyakcikrcgqaggqmTGALLLSVVGGKMSEGINFSDDLGRCVIMVGMPYPNIKSPELQEKMTwl 820
Cdd:cd18788 64 -------------------------------RGALLLAVCRGKVSEGIDFSDDLGRAVIMVGIPYPNTKDPILKLKMD-- 110
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 2201709883 821 DKTMPRSASQAPSRVLIENLCMKAVNQSIGRAIRHQKDYASILLLDH 867
Cdd:cd18788 111 DLEYLRDKGLLTGEDWYTFQAMRAVNQAIGRAIRHKNDYGAIVLLDK 157
|
|
| DEAD_2 |
pfam06733 |
DEAD_2; This represents a conserved region within a number of RAD3-like DNA-binding helicases ... |
232-414 |
1.52e-65 |
|
DEAD_2; This represents a conserved region within a number of RAD3-like DNA-binding helicases that are seemingly ubiquitous - members include proteins of eukaryotic, bacterial and archaeal origin. RAD3 is involved in nucleotide excision repair, and forms part of the transcription factor TFIIH in yeast.
Pssm-ID: 399602 [Multi-domain] Cd Length: 168 Bit Score: 216.75 E-value: 1.52e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 232 YCSRTHSQLSQFVHEVQKSPFGKDTRLVSLGSRQNLCVNEEVRRLGALQLINDRCTEMQKNKHEKKsdaevegkkrrvsr 311
Cdd:pfam06733 1 YCSRTHSQLEQVVKELRRLPYYKKIRGLILGSRKNLCINPEVLKLKKGNLVNERCRELVKSKARGS-------------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 312 tvCPFYS-YEQMQFLRDEVLVEVKDIEQLVTLGKETKACPYYGSRYAIPAAQLVVLPYQMLLHEATRSAAGIILKDQVVI 390
Cdd:pfam06733 67 --CPFYNnLEDLLKLRDLLGDEVMDIEDLVELGEKLGICPYYLSRELIPDADIIILPYNYLLDPKIRESLSINLKNSIVI 144
|
170 180
....*....|....*....|....
gi 2201709883 391 IDEAHNLIDTITCIYSAEVSGSQL 414
Cdd:pfam06733 145 FDEAHNIEDVCIESASFSISRSQL 168
|
|
| DinG |
COG1199 |
Rad3-related DNA helicase DinG [Replication, recombination and repair]; |
349-866 |
4.56e-25 |
|
Rad3-related DNA helicase DinG [Replication, recombination and repair];
Pssm-ID: 440812 [Multi-domain] Cd Length: 629 Bit Score: 111.17 E-value: 4.56e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 349 CPYYGSRYAIPAAQLVVLPYQMLL-HEATRSAagIILKDQVVIIDEAHNLIDTITCIYSAEVSgsqlccaHSQLLQYMER 427
Cdd:COG1199 176 CPYELARRLAREADVVVVNHHLLFaDLALGEE--LLPEDDVLIIDEAHNLPDRARDMFSAELS-------SRSLLRLLRE 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 428 YRKRLKAKNLmyiKQILYLLERFvvmlggnvnqnpscqvvsqtgteLKSINDFlfqsqidninlfkvqrycekslisRKL 507
Cdd:COG1199 247 LRKLGLRPGL---KKLLDLLERL-----------------------REALDDL------------------------FLA 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 508 FGFVERYGNPAPVVKTNKEN--QKLAGLQNFLMTLQQgSYKEGPLQSPPVEadsdqlRAASPLMHIEGFLSALTNANEDG 585
Cdd:COG1199 277 LEEEEELRLALGELPDEPEEllEALDALRDALEALAE-ALEEELERLAELD------ALLERLEELLFALARFLRIAEDE 349
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 586 RVILNRQGTIGQSSLKFLLLNPAVHFAKVV-KECRAVIIAGGTMQ---PVADFREQLlsyaGVDpARIVEFSCGHVIPPE 661
Cdd:COG1199 350 GYVRWLEREGGDVRLHAAPLDPADLLRELLfSRARSVVLTSATLSvggPFDYFARRL----GLD-EDARTLSLPSPFDYE 424
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 662 NILPIILCSGPSnqqleftyQTRDLPQMMDETGRILCNLCNVVPGGVVCFFPSYDYEKQVYAHWEKtglltrlATKKKIF 741
Cdd:COG1199 425 NQALLYVPRDLP--------RPSDRDGYLEAIAEAIAELLEASGGNTLVLFTSYRALEQVAELLRE-------RLDIPVL 489
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 742 QEPKKANqvEQVLAEYakcikrcgQAGGqmtGALLLSvvGGKMSEGINFSDDLGRCVIMVGMPYPNIKSPELQEKMTWLD 821
Cdd:COG1199 490 VQGDGSR--EALLERF--------REGG---NSVLVG--TGSFWEGVDLPGDALSLVIIVKLPFPPPDDPVLEARREALE 554
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 2201709883 822 KTM--PRSASQAPSRVLienlcmkAVNQSIGRAIRHQKDYASILLLD 866
Cdd:COG1199 555 ARGgnGFMYAYLPPAVI-------KLKQGAGRLIRSEEDRGVVVLLD 594
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
70-339 |
2.54e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 45.13 E-value: 2.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 70 EKKKQEEEARLLAPEGSGQEEKQTLASGGLVCPNSRDASGepdwvtafVQKKEEQDLVHRLKEEQIRRKKRE-ERLEKIR 148
Cdd:PTZ00121 1487 EAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADE--------AKKAEEAKKADEAKKAEEKKKADElKKAEELK 1558
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 149 HNVQLKYAAKRKRSEED--------------ETKRLLQLSKEILSEGAGAAvpEQLDHNEEELILAEY--ESDEEKKvas 212
Cdd:PTZ00121 1559 KAEEKKKAEEAKKAEEDknmalrkaeeakkaEEARIEEVMKLYEEEKKMKA--EEAKKAEEAKIKAEElkKAEEEKK--- 1633
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 213 gleedddddleeehvtKIYYCSRTHSQLSQFVHEVQKSPFGKDTRLVSLGSRQnlcvnEEVRRlgalqlindRCTEMQKN 292
Cdd:PTZ00121 1634 ----------------KVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKA-----EEDKK---------KAEEAKKA 1683
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2201709883 293 KHEKKSDAEVEGKKRRVSRTVcpfysyEQMQFLRDEvlvEVKDIEQL 339
Cdd:PTZ00121 1684 EEDEKKAAEALKKEAEEAKKA------EELKKKEAE---EKKKAEEL 1721
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
70-426 |
5.34e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 43.98 E-value: 5.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 70 EKKKQEEEARLLAPEGSGQEE--------KQTLASGGLVCPNSRDASGEPDWVTAFVQKKEEQDL--VHRLKEEQIRRKK 139
Cdd:PTZ00121 1610 EEAKKAEEAKIKAEELKKAEEekkkveqlKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKkkAEEAKKAEEDEKK 1689
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 140 REERLEkiRHNVQLKYAAKRKRSEEDETKRLLQLSKEilsEGAGAAVPEQLDHNEEE----LILAEYESDEEKKVASGLE 215
Cdd:PTZ00121 1690 AAEALK--KEAEEAKKAEELKKKEAEEKKKAEELKKA---EEENKIKAEEAKKEAEEdkkkAEEAKKDEEEKKKIAHLKK 1764
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 216 EDDDDDLEEEHVTKIYYCSRTHSQLSQFVHEVQKSPfgKDTR-----LVSLGSRQNLCVNE----------EVRRLGALQ 280
Cdd:PTZ00121 1765 EEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKI--KDIFdnfanIIEGGKEGNLVINDskemedsaikEVADSKNMQ 1842
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 281 LinDRCTEMQKNKHEKKSDAEVEGKKRRVSRTvcpfYSYEQMQFLrdEVLVEVKDIEQLVT--LGKETKACPYYGSRYAI 358
Cdd:PTZ00121 1843 L--EEADAFEKHKFNKNNENGEDGNKEADFNK----EKDLKEDDE--EEIEEADEIEKIDKddIEREIPNNNMAGKNNDI 1914
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2201709883 359 PAAQLVVLPYQMLLHEATRSAAGIILKDQVVIIDEAHNLID----TITCIYSAEVSGSQLCCAHSQL-LQYME 426
Cdd:PTZ00121 1915 IDDKLDKDEYIKRDAEETREEIIKISKKDMCINDFSSKFCDymkdNISSGNCSDEERKELCCSISDFcLKYFD 1987
|
|
| Csf4_U |
cd09708 |
CRISPR/Cas system-associated DinG family helicase Csf4; CRISPR (Clustered Regularly ... |
27-68 |
1.75e-03 |
|
CRISPR/Cas system-associated DinG family helicase Csf4; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DinG family DNA helicase
Pssm-ID: 187839 [Multi-domain] Cd Length: 632 Bit Score: 41.88 E-value: 1.75e-03
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 2201709883 27 QEQFMAALYAALEAGRIGIFESPTGTGKSLSLICGALSWLQD 68
Cdd:cd09708 2 QALFYRNCLTSLRQKRIGMLEASTGVGKTLAMIMAALTMLKE 43
|
|
| DUF4670 |
pfam15709 |
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ... |
119-201 |
2.70e-03 |
|
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.
Pssm-ID: 464815 [Multi-domain] Cd Length: 522 Bit Score: 41.48 E-value: 2.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 119 QKKEEQDLVHRLKEEQIR-RKKR--EERL----EKIRHNVQLKYAAKRKRSEEDETKR-LLQLSKEILSEGAGAAVPEQL 190
Cdd:pfam15709 373 KMREELELEQQRRFEEIRlRKQRleEERQrqeeEERKQRLQLQAAQERARQQQEEFRRkLQELQRKKQQEEAERAEAEKQ 452
|
90
....*....|.
gi 2201709883 191 DHNEEELILAE 201
Cdd:pfam15709 453 RQKELEMQLAE 463
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| rad3 |
TIGR00604 |
DNA repair helicase (rad3); All proteins in this family for which funcitons are known are ... |
227-866 |
1.57e-154 |
|
DNA repair helicase (rad3); All proteins in this family for which funcitons are known are DNA-DNA helicases that funciton in the initiation of transcription and nucleotide excision repair as part of the TFIIH complex. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273169 [Multi-domain] Cd Length: 705 Bit Score: 470.35 E-value: 1.57e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 227 VTKIYYCSRTHSQLSQFVHEVQK--SPFGK------DTRLVSLGSRQNLCVNEEVRRLGALQLINDRCTEMQKNKHEkks 298
Cdd:TIGR00604 60 VRKIIYASRTHSQLEQATEELRKlmSYRTPrigeesPVSGLSLASRKNLCLHPEVSKERQGKVVNGKCIKLTVSKIK--- 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 299 daevEGKKRRVSRTVCPFY-SYEQMQFLRDEVLVEVKDIEQLVTLGKETKACPYYGSRYAIPAAQLVVLPYQMLLHEATR 377
Cdd:TIGR00604 137 ----EQRTEKPNVESCEFYeNFDELREVEDLLLSEIMDIEDLVEYGELLGLCPYFATRKMLPFANIVLLPYQYLLDPKIR 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 378 SAAGIILKDQVVIIDEAHNLIDTITCIYSAEVSGSQLCCAHSQLLQYMERYRKRLKAKNLMYIKQILYLLErfvVMLGGN 457
Cdd:TIGR00604 213 SAVSIELKDSIVIFDEAHNLDNVCISSLSSNLSVRSLKRCSKEIAEYFEKIEERKEVDARKLLDELQKLVE---GLKQED 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 458 VNQNPSCQVVSQTGTELKSINDFLFQSQIDNINLFKVQRYCEKSLISRKLFGFVERYgnPAPVVKTNKENQKLAGLQNFL 537
Cdd:TIGR00604 290 LLTDEDIFLANPVLPKEVLPEAVPGNIRIAEIFLHKLSRYLEYLKDALKVLGVVSEL--PDAFLEHLKEKTFIDRPLRFC 367
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 538 MtlqqgSYKEGPLQSPPVeADSDQLRAASPLMHIEGFLSALTNANEDGRVILNRQGTIGQsSLKFLLLNPAVHFAKVVKE 617
Cdd:TIGR00604 368 S-----ERLSNLLRELEI-THPEDFSALVLLFTFATLVLTYTNGFLEGIEPYENKTVPNP-ILKFMCLDPSIALKPLFER 440
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 618 CRAVIIAGGTMQPVADFREQLlsyaGVDParIVEFSCGHVIPPENILPIILCSGPSNQQLEFTYQTRDLPQMMDETGRIL 697
Cdd:TIGR00604 441 VRSVILASGTLSPLDAFPRNL----GFNP--VSQDSPTHILKRENLLTLIVTRGSDQVPLSSTFEIRNDPSLVRNLGELL 514
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 698 CNLCNVVPGGVVCFFPSYDYEKQVYAHWEKTGLLTRLATKKKIFQEPKKANQVEQVLAEYAkcikrcgQAGGQMTGALLL 777
Cdd:TIGR00604 515 VEFSKIIPDGIVVFFPSYSYLENIVSTWKEMGILENIEKKKLIFVETKDAQETSDALERYK-------QAVSEGRGAVLL 587
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 778 SVVGGKMSEGINFSDDLGRCVIMVGMPYPNIKSPELQEKMTWLDKTMPRSASQApsrvLIENLCMKAVNQSIGRAIRHQK 857
Cdd:TIGR00604 588 SVAGGKVSEGIDFCDDLGRAVIMVGIPYEYTESRILLARLEFLRDQYPIRENQD----FYEFDAMRAVNQAIGRVIRHKD 663
|
....*....
gi 2201709883 858 DYASILLLD 866
Cdd:TIGR00604 664 DYGSIVLLD 672
|
|
| DEXDc2 |
smart00488 |
DEAD-like helicases superfamily; |
16-436 |
1.95e-85 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214693 [Multi-domain] Cd Length: 289 Bit Score: 275.03 E-value: 1.95e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 16 SFPFPYTPYRIQEQFMAALYAALEAGRIGIFESPTGTGKSLSLICGALSWLQDFEKKKQEeearllapegsgqeekqtla 95
Cdd:smart00488 2 LFYFPYEPYPIQYEFMEELKRVLDRGKIGILESPTGTGKTLSLLCLTLTWLRSFPERIQK-------------------- 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 96 sgglvcpnsrdasGEPDWVTAFVqkkeeqdlvhrlkeeqirrKKREERLEKIRHNVQLKyaakrkrseedetkrllqlsk 175
Cdd:smart00488 62 -------------IKLIYLSRTV-------------------SEIEKRLEELRKLMQKV--------------------- 88
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 176 eilsegagaavpeqldhneeelilaEYESDEEkkvasgleedddddleeehvtkiyycsrtHSQLSQFVHEVqkSPFGKD 255
Cdd:smart00488 89 -------------------------EYESDEE-----------------------------SEKQAQLLHEL--GREKPK 112
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 256 TRLVSLGSRQNLCVNEEVRRLGALQLIND-RCTEMQKNKHEKKsdaevegKKRRVSRTVCPFYSYEQMQFLRDEVLVEVK 334
Cdd:smart00488 113 VLGLSLTSRKNLCLNPEVRTLKQNGLVVDeVCRSLTASKARKY-------RYENPKVERCPFYENTEFLLVRDLLPAEVY 185
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 335 DIEQLVTLGKETKACPYYGSRYAIPAAQLVVLPYQMLLHEATRSAAGIILKDQVVIIDEAHNLIDTITCIYSAEVSGSQL 414
Cdd:smart00488 186 DIEDLLELGKRLGGCPYFASRKAIEFANVVVLPYQYLLDPKIRQALSIELKDSIVIFDEAHNLDNVCISALSSELSRRSL 265
|
410 420
....*....|....*....|....
gi 2201709883 415 CCAHSQLLQYMERYRK--RLKAKN 436
Cdd:smart00488 266 ERAHKNIKKYFERIEKirENDAKR 289
|
|
| SF2_C_XPD |
cd18788 |
C-terminal helicase domain of xeroderma pigmentosum group D (XPD) family DEAD-like helicases; ... |
661-867 |
6.06e-71 |
|
C-terminal helicase domain of xeroderma pigmentosum group D (XPD) family DEAD-like helicases; The xeroderma pigmentosum group D (XPD)-like family members are DEAD-box helicases belonging to superfamily (SF)2. This family includes DDX11 (also called ChlR1), a protein involved in maintaining chromosome transmission fidelity and genome stability, the TFIIH basal transcription factor complex XPD subunit, and FANCJ (also known as BRIP1), a DNA helicase required for the maintenance of chromosomal stability. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350175 [Multi-domain] Cd Length: 159 Bit Score: 230.95 E-value: 6.06e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 661 ENILPIILCSGPSNQQLEFTYQTRDLPQMMDETGRILCNLCNVVPGGVVCFFPSYDYEKQVYAhwektglltrlatkkki 740
Cdd:cd18788 1 DQVCPGIVGRGPDQQALNSKFQTREDEAVMDELGNLLLELCAVVPDGVLVFFPSYSYMERVVS----------------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 741 fqepkkanqveqvlaeyakcikrcgqaggqmTGALLLSVVGGKMSEGINFSDDLGRCVIMVGMPYPNIKSPELQEKMTwl 820
Cdd:cd18788 64 -------------------------------RGALLLAVCRGKVSEGIDFSDDLGRAVIMVGIPYPNTKDPILKLKMD-- 110
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 2201709883 821 DKTMPRSASQAPSRVLIENLCMKAVNQSIGRAIRHQKDYASILLLDH 867
Cdd:cd18788 111 DLEYLRDKGLLTGEDWYTFQAMRAVNQAIGRAIRHKNDYGAIVLLDK 157
|
|
| DEAD_2 |
pfam06733 |
DEAD_2; This represents a conserved region within a number of RAD3-like DNA-binding helicases ... |
232-414 |
1.52e-65 |
|
DEAD_2; This represents a conserved region within a number of RAD3-like DNA-binding helicases that are seemingly ubiquitous - members include proteins of eukaryotic, bacterial and archaeal origin. RAD3 is involved in nucleotide excision repair, and forms part of the transcription factor TFIIH in yeast.
Pssm-ID: 399602 [Multi-domain] Cd Length: 168 Bit Score: 216.75 E-value: 1.52e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 232 YCSRTHSQLSQFVHEVQKSPFGKDTRLVSLGSRQNLCVNEEVRRLGALQLINDRCTEMQKNKHEKKsdaevegkkrrvsr 311
Cdd:pfam06733 1 YCSRTHSQLEQVVKELRRLPYYKKIRGLILGSRKNLCINPEVLKLKKGNLVNERCRELVKSKARGS-------------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 312 tvCPFYS-YEQMQFLRDEVLVEVKDIEQLVTLGKETKACPYYGSRYAIPAAQLVVLPYQMLLHEATRSAAGIILKDQVVI 390
Cdd:pfam06733 67 --CPFYNnLEDLLKLRDLLGDEVMDIEDLVELGEKLGICPYYLSRELIPDADIIILPYNYLLDPKIRESLSINLKNSIVI 144
|
170 180
....*....|....*....|....
gi 2201709883 391 IDEAHNLIDTITCIYSAEVSGSQL 414
Cdd:pfam06733 145 FDEAHNIEDVCIESASFSISRSQL 168
|
|
| Helicase_C_2 |
pfam13307 |
Helicase C-terminal domain; This domain is found at the C-terminus of DEAD-box helicases. |
699-867 |
6.26e-54 |
|
Helicase C-terminal domain; This domain is found at the C-terminus of DEAD-box helicases.
Pssm-ID: 463840 [Multi-domain] Cd Length: 168 Bit Score: 184.69 E-value: 6.26e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 699 NLCNVVPGGVVCFFPSYDYEKQVYAHWEKTGLltrlATKKKIFQEPKkANQVEQVLAEYAKCIKrcgqaggqmtGALLLS 778
Cdd:pfam13307 2 RLLKVIPGGVLVFFPSYSYLEKVAERLKESGL----EKGIEIFVQPG-EGSREKLLEEFKKKGK----------GAVLFG 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 779 VVGGKMSEGINFSDDLGRCVIMVGMPYPNIKSPELQEKMTWLDKTMPRsasqaPSRVLIENLCMKAVNQSIGRAIRHQKD 858
Cdd:pfam13307 67 VCGGSFSEGIDFPGDLLRAVIIVGLPFPNPDDPVVEAKREYLDSKGGN-----PFNEWYLPQAVRAVNQAIGRLIRHEND 141
|
....*....
gi 2201709883 859 YASILLLDH 867
Cdd:pfam13307 142 YGAIVLLDS 150
|
|
| HELICc2 |
smart00491 |
helicase superfamily c-terminal domain; |
715-867 |
2.96e-48 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 214694 [Multi-domain] Cd Length: 142 Bit Score: 167.84 E-value: 2.96e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 715 YDYEKQVYAHWEKTGLLTRlatKKKIFQEPKKANQVEQVLAEYAKCIKRCGqaggqmtgALLLSVVGGKMSEGINFSDDL 794
Cdd:smart00491 1 YRYLEQVVEYWKENGILEI---NKPVFIEGKDSGETEELLEKYSAACEARG--------ALLLAVARGKVSEGIDFPDDL 69
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2201709883 795 GRCVIMVGMPYPNIKSPELQEKMTWLDKTMPRSASQAPSrvliENLCMKAVNQSIGRAIRHQKDYASILLLDH 867
Cdd:smart00491 70 GRAVIIVGIPFPNPDSPILRARLEYLDEKGGIRPFDEVY----LFDAMRALAQAIGRAIRHKNDYGVVVLLDK 138
|
|
| DEAHc_DDX11_starthere |
cd17968 |
DEAH-box helicase domain of ATP-dependent DNA helicase DDX11; DDX11 (also called ChlR1) ... |
227-398 |
4.32e-35 |
|
DEAH-box helicase domain of ATP-dependent DNA helicase DDX11; DDX11 (also called ChlR1) encodes a protein of the conserved family of Iron-Sulfur (Fe-S) cluster DNA helicases and is thought to function in maintaining chromosome transmission fidelity and genome stability. Mutations in the Chl1 human homologs ChlR1/DDX11 and BACH1/BRIP1/FANCJ collectively result in Warsaw Breakage Syndrome, Fanconi anemia, cell aneuploidy and breast and ovarian cancers. DDX11 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350726 Cd Length: 134 Bit Score: 130.13 E-value: 4.32e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 227 VTKIYYCSRTHSQLSQFVHEVQKSPFGKDTRLVSLGSRQnlcvneevrrlgalqlindrctemqknkhekksdaevegkk 306
Cdd:cd17968 26 LTKIYYCSRTHSQLAQFVHEVQKSPFGKDVRLVSLGSRQ----------------------------------------- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 307 rrvsrtvcpfysyeqmqflrdevlvevkdieqlvtlgketkacpyygsryaiPAAQLVVLPYQMLLHEATRSAAGIILKD 386
Cdd:cd17968 65 ----------------------------------------------------PAAQVVVLPYQMLLHAATRKASGIKLKD 92
|
170
....*....|..
gi 2201709883 387 QVVIIDEAHNLI 398
Cdd:cd17968 93 QVVIIDEAHNLI 104
|
|
| DinG |
COG1199 |
Rad3-related DNA helicase DinG [Replication, recombination and repair]; |
349-866 |
4.56e-25 |
|
Rad3-related DNA helicase DinG [Replication, recombination and repair];
Pssm-ID: 440812 [Multi-domain] Cd Length: 629 Bit Score: 111.17 E-value: 4.56e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 349 CPYYGSRYAIPAAQLVVLPYQMLL-HEATRSAagIILKDQVVIIDEAHNLIDTITCIYSAEVSgsqlccaHSQLLQYMER 427
Cdd:COG1199 176 CPYELARRLAREADVVVVNHHLLFaDLALGEE--LLPEDDVLIIDEAHNLPDRARDMFSAELS-------SRSLLRLLRE 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 428 YRKRLKAKNLmyiKQILYLLERFvvmlggnvnqnpscqvvsqtgteLKSINDFlfqsqidninlfkvqrycekslisRKL 507
Cdd:COG1199 247 LRKLGLRPGL---KKLLDLLERL-----------------------REALDDL------------------------FLA 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 508 FGFVERYGNPAPVVKTNKEN--QKLAGLQNFLMTLQQgSYKEGPLQSPPVEadsdqlRAASPLMHIEGFLSALTNANEDG 585
Cdd:COG1199 277 LEEEEELRLALGELPDEPEEllEALDALRDALEALAE-ALEEELERLAELD------ALLERLEELLFALARFLRIAEDE 349
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 586 RVILNRQGTIGQSSLKFLLLNPAVHFAKVV-KECRAVIIAGGTMQ---PVADFREQLlsyaGVDpARIVEFSCGHVIPPE 661
Cdd:COG1199 350 GYVRWLEREGGDVRLHAAPLDPADLLRELLfSRARSVVLTSATLSvggPFDYFARRL----GLD-EDARTLSLPSPFDYE 424
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 662 NILPIILCSGPSnqqleftyQTRDLPQMMDETGRILCNLCNVVPGGVVCFFPSYDYEKQVYAHWEKtglltrlATKKKIF 741
Cdd:COG1199 425 NQALLYVPRDLP--------RPSDRDGYLEAIAEAIAELLEASGGNTLVLFTSYRALEQVAELLRE-------RLDIPVL 489
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 742 QEPKKANqvEQVLAEYakcikrcgQAGGqmtGALLLSvvGGKMSEGINFSDDLGRCVIMVGMPYPNIKSPELQEKMTWLD 821
Cdd:COG1199 490 VQGDGSR--EALLERF--------REGG---NSVLVG--TGSFWEGVDLPGDALSLVIIVKLPFPPPDDPVLEARREALE 554
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 2201709883 822 KTM--PRSASQAPSRVLienlcmkAVNQSIGRAIRHQKDYASILLLD 866
Cdd:COG1199 555 ARGgnGFMYAYLPPAVI-------KLKQGAGRLIRSEEDRGVVVLLD 594
|
|
| DEAHc_FancJ |
cd17970 |
DEAH-box helicase domain of Fanconi anemia group J protein and similar proteins; Fanconi ... |
229-397 |
3.19e-19 |
|
DEAH-box helicase domain of Fanconi anemia group J protein and similar proteins; Fanconi anemia group J protein (FACJ or FANCJ, also known as BRIP1) is a DNA helicase required for the maintenance of chromosomal stability. It plays a role in the repair of DNA double-strand breaks by homologous recombination dependent on its interaction with BRCA1. FANCJ belongs to the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350728 [Multi-domain] Cd Length: 181 Bit Score: 86.25 E-value: 3.19e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 229 KIYYCSRTHSQLSQFVHEVQKSPFgKDTRLVSLGSRQNLCVNEEVRRLGAlQLINDRCTEMQKNKHEkksdaevegkkrr 308
Cdd:cd17970 48 KIIYASRTHSQLAQVVRELKRTAY-KRPRMTILGSRDHLCIHPVINKLSN-QNANEACMALLSGKNE------------- 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 309 vsrtvcpfysyeqmqflrdevlvevkdieqlvtlgketkacpyygsryaipaAQLVVLPYQMLLHEATRSAAGIILKDQV 388
Cdd:cd17970 113 ----------------------------------------------------ADLVFCPYNYLLDPNIRRSMGLNLKGSV 140
|
....*....
gi 2201709883 389 VIIDEAHNL 397
Cdd:cd17970 141 VIFDEAHNI 149
|
|
| DEAHc_XPD-like |
cd17915 |
DEAH-box helicase domain of XPD family DEAD-like helicases; The xeroderma pigmentosum group D ... |
226-410 |
1.24e-18 |
|
DEAH-box helicase domain of XPD family DEAD-like helicases; The xeroderma pigmentosum group D (XPD)-like family members are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350673 [Multi-domain] Cd Length: 138 Bit Score: 83.25 E-value: 1.24e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 226 HVTKIYYCSRTHSQLSQFVHEVQKSPFGKDTRLVSLGSRqnlcvneevrrlgalqlindrctemqknkhekksdaevegk 305
Cdd:cd17915 30 HKTKVLYCSRTHSQIEQIIRELRKLLEKRKIRALALSSR----------------------------------------- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 306 krrvsrtvcpfysyeqmqflrdevlvevkdieqlvtlgketkacpyygsryaipAAQLVVLPYQMLLHEATRSAAGIILK 385
Cdd:cd17915 69 ------------------------------------------------------DADIVVLPYPYLLDARIREFIGIDLR 94
|
170 180
....*....|....*....|....*
gi 2201709883 386 DQVVIIDEAHNLIDTITCIYSAEVS 410
Cdd:cd17915 95 EQVVIIDEAHNLDERSVIITSGTLS 119
|
|
| DEAHc_DDX11_starthere |
cd17968 |
DEAH-box helicase domain of ATP-dependent DNA helicase DDX11; DDX11 (also called ChlR1) ... |
618-647 |
2.83e-11 |
|
DEAH-box helicase domain of ATP-dependent DNA helicase DDX11; DDX11 (also called ChlR1) encodes a protein of the conserved family of Iron-Sulfur (Fe-S) cluster DNA helicases and is thought to function in maintaining chromosome transmission fidelity and genome stability. Mutations in the Chl1 human homologs ChlR1/DDX11 and BACH1/BRIP1/FANCJ collectively result in Warsaw Breakage Syndrome, Fanconi anemia, cell aneuploidy and breast and ovarian cancers. DDX11 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350726 Cd Length: 134 Bit Score: 61.95 E-value: 2.83e-11
10 20 30
....*....|....*....|....*....|
gi 2201709883 618 CRAVIIAGGTMQPVADFREQLLSYAGVDPA 647
Cdd:cd17968 105 CRAVIIAGGTMQPVADFKEQLLFSAGVTPE 134
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
70-339 |
2.54e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 45.13 E-value: 2.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 70 EKKKQEEEARLLAPEGSGQEEKQTLASGGLVCPNSRDASGepdwvtafVQKKEEQDLVHRLKEEQIRRKKRE-ERLEKIR 148
Cdd:PTZ00121 1487 EAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADE--------AKKAEEAKKADEAKKAEEKKKADElKKAEELK 1558
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 149 HNVQLKYAAKRKRSEED--------------ETKRLLQLSKEILSEGAGAAvpEQLDHNEEELILAEY--ESDEEKKvas 212
Cdd:PTZ00121 1559 KAEEKKKAEEAKKAEEDknmalrkaeeakkaEEARIEEVMKLYEEEKKMKA--EEAKKAEEAKIKAEElkKAEEEKK--- 1633
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 213 gleedddddleeehvtKIYYCSRTHSQLSQFVHEVQKSPFGKDTRLVSLGSRQnlcvnEEVRRlgalqlindRCTEMQKN 292
Cdd:PTZ00121 1634 ----------------KVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKA-----EEDKK---------KAEEAKKA 1683
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2201709883 293 KHEKKSDAEVEGKKRRVSRTVcpfysyEQMQFLRDEvlvEVKDIEQL 339
Cdd:PTZ00121 1684 EEDEKKAAEALKKEAEEAKKA------EELKKKEAE---EKKKAEEL 1721
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
70-426 |
5.34e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 43.98 E-value: 5.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 70 EKKKQEEEARLLAPEGSGQEE--------KQTLASGGLVCPNSRDASGEPDWVTAFVQKKEEQDL--VHRLKEEQIRRKK 139
Cdd:PTZ00121 1610 EEAKKAEEAKIKAEELKKAEEekkkveqlKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKkkAEEAKKAEEDEKK 1689
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 140 REERLEkiRHNVQLKYAAKRKRSEEDETKRLLQLSKEilsEGAGAAVPEQLDHNEEE----LILAEYESDEEKKVASGLE 215
Cdd:PTZ00121 1690 AAEALK--KEAEEAKKAEELKKKEAEEKKKAEELKKA---EEENKIKAEEAKKEAEEdkkkAEEAKKDEEEKKKIAHLKK 1764
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 216 EDDDDDLEEEHVTKIYYCSRTHSQLSQFVHEVQKSPfgKDTR-----LVSLGSRQNLCVNE----------EVRRLGALQ 280
Cdd:PTZ00121 1765 EEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKI--KDIFdnfanIIEGGKEGNLVINDskemedsaikEVADSKNMQ 1842
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 281 LinDRCTEMQKNKHEKKSDAEVEGKKRRVSRTvcpfYSYEQMQFLrdEVLVEVKDIEQLVT--LGKETKACPYYGSRYAI 358
Cdd:PTZ00121 1843 L--EEADAFEKHKFNKNNENGEDGNKEADFNK----EKDLKEDDE--EEIEEADEIEKIDKddIEREIPNNNMAGKNNDI 1914
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2201709883 359 PAAQLVVLPYQMLLHEATRSAAGIILKDQVVIIDEAHNLID----TITCIYSAEVSGSQLCCAHSQL-LQYME 426
Cdd:PTZ00121 1915 IDDKLDKDEYIKRDAEETREEIIKISKKDMCINDFSSKFCDymkdNISSGNCSDEERKELCCSISDFcLKYFD 1987
|
|
| Csf4_U |
cd09708 |
CRISPR/Cas system-associated DinG family helicase Csf4; CRISPR (Clustered Regularly ... |
27-68 |
1.75e-03 |
|
CRISPR/Cas system-associated DinG family helicase Csf4; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DinG family DNA helicase
Pssm-ID: 187839 [Multi-domain] Cd Length: 632 Bit Score: 41.88 E-value: 1.75e-03
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 2201709883 27 QEQFMAALYAALEAGRIGIFESPTGTGKSLSLICGALSWLQD 68
Cdd:cd09708 2 QALFYRNCLTSLRQKRIGMLEASTGVGKTLAMIMAALTMLKE 43
|
|
| DUF4670 |
pfam15709 |
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ... |
119-201 |
2.70e-03 |
|
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.
Pssm-ID: 464815 [Multi-domain] Cd Length: 522 Bit Score: 41.48 E-value: 2.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 119 QKKEEQDLVHRLKEEQIR-RKKR--EERL----EKIRHNVQLKYAAKRKRSEEDETKR-LLQLSKEILSEGAGAAVPEQL 190
Cdd:pfam15709 373 KMREELELEQQRRFEEIRlRKQRleEERQrqeeEERKQRLQLQAAQERARQQQEEFRRkLQELQRKKQQEEAERAEAEKQ 452
|
90
....*....|.
gi 2201709883 191 DHNEEELILAE 201
Cdd:pfam15709 453 RQKELEMQLAE 463
|
|
| Caldesmon |
pfam02029 |
Caldesmon; |
67-209 |
9.30e-03 |
|
Caldesmon;
Pssm-ID: 460421 [Multi-domain] Cd Length: 495 Bit Score: 39.47 E-value: 9.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201709883 67 QDFEKKKQEEEARLLAPEGSGQEEKQTLASGGLVCPNSRDASGEPDWVTAFVQKKEEQDLvHRLKEEQIRRKKREERLEK 146
Cdd:pfam02029 17 EERRRQKEEEEPSGQVTESVEPNEHNSYEEDSELKPSGQGGLDEEEAFLDRTAKREERRQ-KRLQEALERQKEFDPTIAD 95
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2201709883 147 IRHNVQLKyaAKRKRSEEDET---KRLLQLSKEILSEGAGAAVPEQLDHN--EEELILAEYESDEEKK 209
Cdd:pfam02029 96 EKESVAER--KENNEEEENSSwekEEKRDSRLGRYKEEETEIREKEYQENkwSTEVRQAEEEGEEEED 161
|
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