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Conserved domains on  [gi|2201764096|ref|XP_046767420|]
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protein Abitram isoform X1 [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Biotinyl_lipoyl_domains super family cl11404
Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the ...
 167-235 1.61e-08

Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, or methylamine, respectively, between components of the complex/protein via a biotinyl or lipoyl group, which is covalently attached to a highly conserved lysine residue.


The actual alignment was detected with superfamily member PRK01202:

Pssm-ID: 448245  Cd Length: 127  Bit Score: 51.70  E-value: 1.61e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2201764096 167 ASSDgeeytIYSCIRGRLIEVNENILSSPALLQEKPSTEGYIAVVLPkfeESKSVTQGLLTPEEYKEVL 235
Cdd:PRK01202   65 AASD-----IYAPVSGEVVEVNEALEDSPELVNEDPYGEGWLFKIKP---SDESELDDLLDAEAYEALI 125
 
Name Accession Description Interval E-value
PRK01202 PRK01202
glycine cleavage system protein GcvH;
167-235 1.61e-08

glycine cleavage system protein GcvH;


Pssm-ID: 234918  Cd Length: 127  Bit Score: 51.70  E-value: 1.61e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2201764096 167 ASSDgeeytIYSCIRGRLIEVNENILSSPALLQEKPSTEGYIAVVLPkfeESKSVTQGLLTPEEYKEVL 235
Cdd:PRK01202   65 AASD-----IYAPVSGEVVEVNEALEDSPELVNEDPYGEGWLFKIKP---SDESELDDLLDAEAYEALI 125
GcvH COG0509
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ...
 176-235 5.88e-07

Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440275  Cd Length: 128  Bit Score: 47.43  E-value: 5.88e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201764096 176 IYSCIRGRLIEVNENILSSPALLQEKPSTEGYIAVVLPkfeESKSVTQGLLTPEEYKEVL 235
Cdd:COG0509    69 LYAPVSGEVVEVNEALEDDPELVNEDPYGEGWLFKIKP---SDPAELDDLLDAEAYAALL 125
GCV_H pfam01597
Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the ...
 175-235 8.11e-07

Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


Pssm-ID: 396258  Cd Length: 122  Bit Score: 46.94  E-value: 8.11e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2201764096 175 TIYSCIRGRLIEVNENILSSPALLQEKPSTEGYIAVVLPK-FEESKSvtqgLLTPEEYKEVL 235
Cdd:pfam01597  62 PIYAPVSGEVVEVNEKLEDNPGLINKDPYEDGWIAKLKPSnLEELES----LMTAEQYEKTL 119
GCS_H cd06848
Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage ...
 169-211 8.71e-05

Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-proteins) which catalyzes the oxidative cleavage of glycine. The H-protein shuttles the methylamine group of glycine from the P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase) via a lipoyl group, attached to a completely conserved lysine residue.


Pssm-ID: 133457 [Multi-domain]  Cd Length: 96  Bit Score: 40.21  E-value: 8.71e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2201764096 169 SDGEEYTIYSCIRGRLIEVNENILSSPALLQEKPSTEGYIAVV 211
Cdd:cd06848    54 SVKAASDLYSPVSGEVVEVNEALLDNPELINSDPYGEGWLVKI 96
 
Name Accession Description Interval E-value
PRK01202 PRK01202
glycine cleavage system protein GcvH;
167-235 1.61e-08

glycine cleavage system protein GcvH;


Pssm-ID: 234918  Cd Length: 127  Bit Score: 51.70  E-value: 1.61e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2201764096 167 ASSDgeeytIYSCIRGRLIEVNENILSSPALLQEKPSTEGYIAVVLPkfeESKSVTQGLLTPEEYKEVL 235
Cdd:PRK01202   65 AASD-----IYAPVSGEVVEVNEALEDSPELVNEDPYGEGWLFKIKP---SDESELDDLLDAEAYEALI 125
GcvH COG0509
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ...
 176-235 5.88e-07

Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440275  Cd Length: 128  Bit Score: 47.43  E-value: 5.88e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201764096 176 IYSCIRGRLIEVNENILSSPALLQEKPSTEGYIAVVLPkfeESKSVTQGLLTPEEYKEVL 235
Cdd:COG0509    69 LYAPVSGEVVEVNEALEDDPELVNEDPYGEGWLFKIKP---SDPAELDDLLDAEAYAALL 125
GCV_H pfam01597
Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the ...
 175-235 8.11e-07

Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


Pssm-ID: 396258  Cd Length: 122  Bit Score: 46.94  E-value: 8.11e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2201764096 175 TIYSCIRGRLIEVNENILSSPALLQEKPSTEGYIAVVLPK-FEESKSvtqgLLTPEEYKEVL 235
Cdd:pfam01597  62 PIYAPVSGEVVEVNEKLEDNPGLINKDPYEDGWIAKLKPSnLEELES----LMTAEQYEKTL 119
GCS_H cd06848
Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage ...
 169-211 8.71e-05

Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-proteins) which catalyzes the oxidative cleavage of glycine. The H-protein shuttles the methylamine group of glycine from the P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase) via a lipoyl group, attached to a completely conserved lysine residue.


Pssm-ID: 133457 [Multi-domain]  Cd Length: 96  Bit Score: 40.21  E-value: 8.71e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2201764096 169 SDGEEYTIYSCIRGRLIEVNENILSSPALLQEKPSTEGYIAVV 211
Cdd:cd06848    54 SVKAASDLYSPVSGEVVEVNEALLDNPELINSDPYGEGWLVKI 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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