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Conserved domains on  [gi|2201822836|ref|XP_046790742|]
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prolactin receptor isoform X2 [Gallus gallus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10046900)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 84-180 7.73e-34

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09067:

Pssm-ID: 473895  Cd Length: 104  Bit Score: 124.84  E-value: 7.73e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836  84 GQSPPEKPTIIKCRSPEKETFTCWWKPGLDGGHPTNYTLLYSKEGeEQVYECPDYRTAGPNS-----CYFDKKHTSFWTI 158
Cdd:pfam09067   4 ALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYEN-ETVKECPLYSTSGANStrlfiCFFPKNDVSLFVP 82

                          90       100
                  ....*....|....*....|..
gi 2201822836 159 YNITVRATNEMGSNSSDPHYVD 180
Cdd:pfam09067  83 LHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 187-282 2.39e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 2.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836 187 PDPPVNVTLElkkpINRKPYLVLTWSPPPladvRSGWLTLEYELRLKPEEGEEWETIFV--GQQTQYKMFSLNPGKKYII 264
Cdd:cd00063     1 PSPPTNLRVT----DVTSTSVTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEF 72

                          90
                  ....*....|....*...
gi 2201822836 265 QIHCKPDhhGSWSEWSSE 282
Cdd:cd00063    73 RVRAVNG--GGESPPSES 88
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 6-79 2.96e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.65  E-value: 2.96e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2201822836   6 KWSPPllADANSNHLyHYELRIKPEEKEEWETISVGV--QTQCKINRLNAGMRYVVQVRCTLDPGeWSEWSSERHI 79
Cdd:cd00063    20 SWTPP--EDDGGPIT-GYVVEYREKGSGDWKEVEVTPgsETSYTLTGLKPGTEYEFRVRAVNGGG-ESPPSESVTV 91
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 84-180 7.73e-34

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 124.84  E-value: 7.73e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836  84 GQSPPEKPTIIKCRSPEKETFTCWWKPGLDGGHPTNYTLLYSKEGeEQVYECPDYRTAGPNS-----CYFDKKHTSFWTI 158
Cdd:pfam09067   4 ALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYEN-ETVKECPLYSTSGANStrlfiCFFPKNDVSLFVP 82

                          90       100
                  ....*....|....*....|..
gi 2201822836 159 YNITVRATNEMGSNSSDPHYVD 180
Cdd:pfam09067  83 LHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 187-282 2.39e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 2.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836 187 PDPPVNVTLElkkpINRKPYLVLTWSPPPladvRSGWLTLEYELRLKPEEGEEWETIFV--GQQTQYKMFSLNPGKKYII 264
Cdd:cd00063     1 PSPPTNLRVT----DVTSTSVTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEF 72

                          90
                  ....*....|....*...
gi 2201822836 265 QIHCKPDhhGSWSEWSSE 282
Cdd:cd00063    73 RVRAVNG--GGESPPSES 88
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 6-79 2.96e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.65  E-value: 2.96e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2201822836   6 KWSPPllADANSNHLyHYELRIKPEEKEEWETISVGV--QTQCKINRLNAGMRYVVQVRCTLDPGeWSEWSSERHI 79
Cdd:cd00063    20 SWTPP--EDDGGPIT-GYVVEYREKGSGDWKEVEVTPgsETSYTLTGLKPGTEYEFRVRAVNGGG-ESPPSESVTV 91
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
157-282 6.30e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 52.70  E-value: 6.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836 157 TIYNITVRATNEMGSNSSDPHYVDVTYIVQPDPPVNVTLELKKPinrkPYLVLTWSPPPLADVRSgwltleYELRLKPEE 236
Cdd:COG3401   203 TTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTP----GSVTLSWDPVTESDATG------YRVYRSNSG 272

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2201822836 237 GEEWETIFVGQQTQYKMFSLNPGKKYIIQIHCKpDHHGSWSEWSSE 282
Cdd:COG3401   273 DGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAV-DAAGNESAPSNV 317
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 187-269 2.86e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 2.86e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836  187 PDPPVNVTLElkkpINRKPYLVLTWSPPPLADVRSgwLTLEYELRLKPEEGEEWETIFVGQQTQYKMFSLNPGKKYIIQI 266
Cdd:smart00060   1 PSPPSNLRVT----DVTSTSVTLSWEPPPDDGITG--YIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                   ...
gi 2201822836  267 HCK 269
Cdd:smart00060  75 RAV 77
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 88-179 3.30e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 3.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836  88 PEKPTIIKCRSPEKETFTCWWK-PGLDGGHPTNYTLLYSKEGEEQVYECPdyrTAGPNSCYFDKKHTSFWTIYNITVRAT 166
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTpPEDDGGPITGYVVEYREKGSGDWKEVE---VTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....
gi 2201822836 167 NEMG-SNSSDPHYV 179
Cdd:cd00063    78 NGGGeSPPSESVTV 91
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
49-282 4.18e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.00  E-value: 4.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836  49 NRLNAGMRYVVQVRCTlDPGEWSEWSSERHILIPSgqSPPEKPTIIKCRSPEKETFTCWWKPGLDGGhPTNYTLLYSKEG 128
Cdd:COG3401   197 GDIEPGTTYYYRVAAT-DTGGESAPSNEVSVTTPT--TPPSAPTGLTATADTPGSVTLSWDPVTESD-ATGYRVYRSNSG 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836 129 EEQvYEcpdYRTAGPNSCYFDKKHTSfWTIYNITVRATNEMGSNSSDPHYVDVTYIVQ-PDPPVNVTLElkKPINRKpyL 207
Cdd:COG3401   273 DGP-FT---KVATVTTTSYTDTGLTN-GTTYYYRVTAVDAAGNESAPSNVVSVTTDLTpPAAPSGLTAT--AVGSSS--I 343

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2201822836 208 VLTWSPPPLADVRSgwltleYELRLKPEEGEEWETI-FVGQQTQYKMFSLNPGKKYIIQIHCKpDHHGSWSEWSSE 282
Cdd:COG3401   344 TLSWTASSDADVTG------YNVYRSTSGGGTYTKIaETVTTTSYTDTGLTPGTTYYYKVTAV-DAAGNESAPSEE 412
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 6-69 3.46e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 3.46e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2201822836    6 KWSPPLLADANSNHLYhYELRIKPEEKEEWETISVGVQTQCKINRLNAGMRYVVQVRCTLDPGE 69
Cdd:smart00060  20 SWEPPPDDGITGYIVG-YRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
fn3 pfam00041
Fibronectin type III domain;
188-280 6.86e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.94  E-value: 6.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836 188 DPPVNVTLelkKPINRKpYLVLTWSPPPladVRSGWLTlEYELRLKPE-EGEEWETIFV-GQQTQYKMFSLNPGKKYIIQ 265
Cdd:pfam00041   1 SAPSNLTV---TDVTST-SLTVSWTPPP---DGNGPIT-GYEVEYRPKnSGEPWNEITVpGTTTSVTLTGLKPGTEYEVR 72

                          90
                  ....*....|....*
gi 2201822836 266 IHCKPDhhGSWSEWS 280
Cdd:pfam00041  73 VQAVNG--GGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
7-74 1.24e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.16  E-value: 1.24e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836   7 WSPPllaDANSNHLYHYELRIKPEEKEEW--ETISVGVQTQCKINRLNAGMRYVVQVRcTLDPGEWSEWS 74
Cdd:pfam00041  20 WTPP---PDGNGPITGYEVEYRPKNSGEPwnEITVPGTTTSVTLTGLKPGTEYEVRVQ-AVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 88-171 2.48e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.59  E-value: 2.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836   88 PEKPTIIKCRSPEKETFTCWWKPGLDGGHpTNYTLLYSKEGEEqVYECPDYRTAGPNSCYFDKKHTSFWTIYNITVRATN 167
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI-TGYIVGYRVEYRE-EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                   ....
gi 2201822836  168 EMGS 171
Cdd:smart00060  79 GAGE 82
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 84-180 7.73e-34

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 124.84  E-value: 7.73e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836  84 GQSPPEKPTIIKCRSPEKETFTCWWKPGLDGGHPTNYTLLYSKEGeEQVYECPDYRTAGPNS-----CYFDKKHTSFWTI 158
Cdd:pfam09067   4 ALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYEN-ETVKECPLYSTSGANStrlfiCFFPKNDVSLFVP 82

                          90       100
                  ....*....|....*....|..
gi 2201822836 159 YNITVRATNEMGSNSSDPHYVD 180
Cdd:pfam09067  83 LHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 187-282 2.39e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 2.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836 187 PDPPVNVTLElkkpINRKPYLVLTWSPPPladvRSGWLTLEYELRLKPEEGEEWETIFV--GQQTQYKMFSLNPGKKYII 264
Cdd:cd00063     1 PSPPTNLRVT----DVTSTSVTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEF 72

                          90
                  ....*....|....*...
gi 2201822836 265 QIHCKPDhhGSWSEWSSE 282
Cdd:cd00063    73 RVRAVNG--GGESPPSES 88
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 6-79 2.96e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.65  E-value: 2.96e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2201822836   6 KWSPPllADANSNHLyHYELRIKPEEKEEWETISVGV--QTQCKINRLNAGMRYVVQVRCTLDPGeWSEWSSERHI 79
Cdd:cd00063    20 SWTPP--EDDGGPIT-GYVVEYREKGSGDWKEVEVTPgsETSYTLTGLKPGTEYEFRVRAVNGGG-ESPPSESVTV 91
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
157-282 6.30e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 52.70  E-value: 6.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836 157 TIYNITVRATNEMGSNSSDPHYVDVTYIVQPDPPVNVTLELKKPinrkPYLVLTWSPPPLADVRSgwltleYELRLKPEE 236
Cdd:COG3401   203 TTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTP----GSVTLSWDPVTESDATG------YRVYRSNSG 272

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2201822836 237 GEEWETIFVGQQTQYKMFSLNPGKKYIIQIHCKpDHHGSWSEWSSE 282
Cdd:COG3401   273 DGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAV-DAAGNESAPSNV 317
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 106-174 1.19e-06

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 47.02  E-value: 1.19e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2201822836 106 CWWKPGLDGGHPTNYTLLYSKEGEEQVYECPDY-RTAGPN-SCYFD--KKHTSFWTIYNITVRATNEMGSNSS 174
Cdd:pfam09240  14 CEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYYiRDDGTRiGCQFDdlEGLSSSFHQVYICVNGSSSAGPIRS 86
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 187-269 2.86e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 2.86e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836  187 PDPPVNVTLElkkpINRKPYLVLTWSPPPLADVRSgwLTLEYELRLKPEEGEEWETIFVGQQTQYKMFSLNPGKKYIIQI 266
Cdd:smart00060   1 PSPPSNLRVT----DVTSTSVTLSWEPPPDDGITG--YIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                   ...
gi 2201822836  267 HCK 269
Cdd:smart00060  75 RAV 77
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 88-179 3.30e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 3.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836  88 PEKPTIIKCRSPEKETFTCWWK-PGLDGGHPTNYTLLYSKEGEEQVYECPdyrTAGPNSCYFDKKHTSFWTIYNITVRAT 166
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTpPEDDGGPITGYVVEYREKGSGDWKEVE---VTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....
gi 2201822836 167 NEMG-SNSSDPHYV 179
Cdd:cd00063    78 NGGGeSPPSESVTV 91
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
49-282 4.18e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.00  E-value: 4.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836  49 NRLNAGMRYVVQVRCTlDPGEWSEWSSERHILIPSgqSPPEKPTIIKCRSPEKETFTCWWKPGLDGGhPTNYTLLYSKEG 128
Cdd:COG3401   197 GDIEPGTTYYYRVAAT-DTGGESAPSNEVSVTTPT--TPPSAPTGLTATADTPGSVTLSWDPVTESD-ATGYRVYRSNSG 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836 129 EEQvYEcpdYRTAGPNSCYFDKKHTSfWTIYNITVRATNEMGSNSSDPHYVDVTYIVQ-PDPPVNVTLElkKPINRKpyL 207
Cdd:COG3401   273 DGP-FT---KVATVTTTSYTDTGLTN-GTTYYYRVTAVDAAGNESAPSNVVSVTTDLTpPAAPSGLTAT--AVGSSS--I 343

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2201822836 208 VLTWSPPPLADVRSgwltleYELRLKPEEGEEWETI-FVGQQTQYKMFSLNPGKKYIIQIHCKpDHHGSWSEWSSE 282
Cdd:COG3401   344 TLSWTASSDADVTG------YNVYRSTSGGGTYTKIaETVTTTSYTDTGLTPGTTYYYKVTAV-DAAGNESAPSEE 412
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
6-218 1.49e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.99  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836   6 KWSPPLLADANSnhlyhYELRIKPEEKEEWETISVGVQTQCKINRLNAGMRYVVQVRCTLDPGEWSEWSSErhILIPSGQ 85
Cdd:COG3401   252 SWDPVTESDATG-----YRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNV--VSVTTDL 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836  86 SPPEKPTIIKCRSPEKETFTCWWKPGlDGGHPTNYTLLYSKEGE---EQVYEcpdyrTAGPNScYFDKKHTSFwTIYNIT 162
Cdd:COG3401   325 TPPAAPSGLTATAVGSSSITLSWTAS-SDADVTGYNVYRSTSGGgtyTKIAE-----TVTTTS-YTDTGLTPG-TTYYYK 396

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2201822836 163 VRATNEMG--SNSSDPHYVDVTYIVQPDPPVNVTLELKKPINRKPYLVLTWSPPPLAD 218
Cdd:COG3401   397 VTAVDAAGneSAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVS 454
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 6-69 3.46e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 3.46e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2201822836    6 KWSPPLLADANSNHLYhYELRIKPEEKEEWETISVGVQTQCKINRLNAGMRYVVQVRCTLDPGE 69
Cdd:smart00060  20 SWEPPPDDGITGYIVG-YRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
fn3 pfam00041
Fibronectin type III domain;
188-280 6.86e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.94  E-value: 6.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836 188 DPPVNVTLelkKPINRKpYLVLTWSPPPladVRSGWLTlEYELRLKPE-EGEEWETIFV-GQQTQYKMFSLNPGKKYIIQ 265
Cdd:pfam00041   1 SAPSNLTV---TDVTST-SLTVSWTPPP---DGNGPIT-GYEVEYRPKnSGEPWNEITVpGTTTSVTLTGLKPGTEYEVR 72

                          90
                  ....*....|....*
gi 2201822836 266 IHCKPDhhGSWSEWS 280
Cdd:pfam00041  73 VQAVNG--GGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
7-74 1.24e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.16  E-value: 1.24e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836   7 WSPPllaDANSNHLYHYELRIKPEEKEEW--ETISVGVQTQCKINRLNAGMRYVVQVRcTLDPGEWSEWS 74
Cdd:pfam00041  20 WTPP---PDGNGPITGYEVEYRPKNSGEPwnEITVPGTTTSVTLTGLKPGTEYEVRVQ-AVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 88-171 2.48e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.59  E-value: 2.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836   88 PEKPTIIKCRSPEKETFTCWWKPGLDGGHpTNYTLLYSKEGEEqVYECPDYRTAGPNSCYFDKKHTSFWTIYNITVRATN 167
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI-TGYIVGYRVEYRE-EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                   ....
gi 2201822836  168 EMGS 171
Cdd:smart00060  79 GAGE 82
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
159-262 2.99e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 41.08  E-value: 2.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201822836 159 YNITVRATNEMGSnSSDPHYVDVTYIVQ----PDPPVNVTLElkkPINRkpYLVLTWSPPPLADvrsgwlTLEYELRLKP 234
Cdd:COG4733   599 YEVRVRAINALGV-SSAWAASSETTVTGktapPPAPTGLTAT---GGLG--GITLSWSFPVDAD------TLRTEIRYST 666

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2201822836 235 eeGEEWET----IFVGQQTQYKMFSLNPGKKY 262
Cdd:COG4733   667 --TGDWASatvaQALYPGNTYTLAGLKAGQTY 696
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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