F-box/WD repeat-containing protein 7 isoform X1 [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| WD40 | COG2319 | WD40 repeat [General function prediction only]; |
311-692 | 3.02e-92 | ||||||
WD40 repeat [General function prediction only]; : Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 292.97 E-value: 3.02e-92
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| F-box_FBXW7 | cd22133 | F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, ... |
264-322 | 2.43e-39 | ||||||
F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. : Pssm-ID: 438905 Cd Length: 59 Bit Score: 138.71 E-value: 2.43e-39
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| Name | Accession | Description | Interval | E-value | ||||||
| WD40 | COG2319 | WD40 repeat [General function prediction only]; |
311-692 | 3.02e-92 | ||||||
WD40 repeat [General function prediction only]; Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 292.97 E-value: 3.02e-92
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| WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
374-650 | 1.68e-91 | ||||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 286.54 E-value: 1.68e-91
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| F-box_FBXW7 | cd22133 | F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, ... |
264-322 | 2.43e-39 | ||||||
F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438905 Cd Length: 59 Bit Score: 138.71 E-value: 2.43e-39
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| F-box-like | pfam12937 | F-box-like; This is an F-box-like family. |
281-325 | 4.01e-15 | ||||||
F-box-like; This is an F-box-like family. Pssm-ID: 463757 [Multi-domain] Cd Length: 45 Bit Score: 69.43 E-value: 4.01e-15
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| PLN00181 | PLN00181 | protein SPA1-RELATED; Provisional |
392-561 | 1.68e-09 | ||||||
protein SPA1-RELATED; Provisional Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 61.26 E-value: 1.68e-09
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| WD40 | smart00320 | WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
610-650 | 1.99e-07 | ||||||
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 47.69 E-value: 1.99e-07
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| WD40 | pfam00400 | WD domain, G-beta repeat; |
532-567 | 2.45e-07 | ||||||
WD domain, G-beta repeat; Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 47.34 E-value: 2.45e-07
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| FBOX | smart00256 | A Receptor for Ubiquitination Targets; |
284-324 | 1.29e-06 | ||||||
A Receptor for Ubiquitination Targets; Pssm-ID: 197608 Cd Length: 41 Bit Score: 45.51 E-value: 1.29e-06
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| Name | Accession | Description | Interval | E-value | ||||||
| WD40 | COG2319 | WD40 repeat [General function prediction only]; |
311-692 | 3.02e-92 | ||||||
WD40 repeat [General function prediction only]; Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 292.97 E-value: 3.02e-92
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| WD40 | COG2319 | WD40 repeat [General function prediction only]; |
365-653 | 8.10e-92 | ||||||
WD40 repeat [General function prediction only]; Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 291.81 E-value: 8.10e-92
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| WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
374-650 | 1.68e-91 | ||||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 286.54 E-value: 1.68e-91
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| WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
453-692 | 2.73e-62 | ||||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 209.88 E-value: 2.73e-62
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| F-box_FBXW7 | cd22133 | F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, ... |
264-322 | 2.43e-39 | ||||||
F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438905 Cd Length: 59 Bit Score: 138.71 E-value: 2.43e-39
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| WD40 | COG2319 | WD40 repeat [General function prediction only]; |
510-692 | 9.64e-22 | ||||||
WD40 repeat [General function prediction only]; Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 98.06 E-value: 9.64e-22
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| F-box_DdgacFF-like | cd22148 | F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) ... |
280-323 | 1.68e-15 | ||||||
F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438919 Cd Length: 44 Bit Score: 70.77 E-value: 1.68e-15
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| F-box-like | pfam12937 | F-box-like; This is an F-box-like family. |
281-325 | 4.01e-15 | ||||||
F-box-like; This is an F-box-like family. Pssm-ID: 463757 [Multi-domain] Cd Length: 45 Bit Score: 69.43 E-value: 4.01e-15
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| F-box_FBXO16-like | cd22094 | F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 ... |
279-325 | 7.63e-14 | ||||||
F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; This family includes FBXO16 and ECT2L. FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438866 Cd Length: 49 Bit Score: 66.32 E-value: 7.63e-14
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| F-box_ECT2L | cd22173 | F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and ... |
279-329 | 8.33e-14 | ||||||
F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438944 Cd Length: 52 Bit Score: 66.28 E-value: 8.33e-14
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| F-box_SpPof1-like | cd22147 | F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ... |
280-325 | 7.23e-13 | ||||||
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438918 Cd Length: 46 Bit Score: 63.10 E-value: 7.23e-13
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| F-box_FBXO16 | cd22172 | F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called ... |
276-325 | 2.07e-12 | ||||||
F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438943 Cd Length: 55 Bit Score: 62.30 E-value: 2.07e-12
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| F-box_FBXO4 | cd22085 | F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called ... |
284-322 | 2.19e-10 | ||||||
F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called FBX4, is a specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that catalyzes the ubiquitination and subsequent degradation of cyclin D1 and Trx1. It recognizes TERF1 and promotes its ubiquitination together with UBE2D1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438857 Cd Length: 50 Bit Score: 56.26 E-value: 2.19e-10
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| F-box_FBXW5 | cd22132 | F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ... |
282-323 | 2.29e-10 | ||||||
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438904 [Multi-domain] Cd Length: 46 Bit Score: 56.08 E-value: 2.29e-10
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| F-box_FBXW8 | cd22134 | F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, ... |
284-325 | 5.37e-10 | ||||||
F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, also called F-box and WD-40 domain-containing protein 8, or F-box only protein 29 (FBXO29), is the substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as GORASP1, IRS1, MAP4K1/HPK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438906 Cd Length: 48 Bit Score: 55.08 E-value: 5.37e-10
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| F-box_unchar | cd22139 | F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 ... |
283-325 | 1.52e-09 | ||||||
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438911 Cd Length: 45 Bit Score: 53.79 E-value: 1.52e-09
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| PLN00181 | PLN00181 | protein SPA1-RELATED; Provisional |
392-561 | 1.68e-09 | ||||||
protein SPA1-RELATED; Provisional Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 61.26 E-value: 1.68e-09
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| PLN00181 | PLN00181 | protein SPA1-RELATED; Provisional |
509-651 | 2.17e-09 | ||||||
protein SPA1-RELATED; Provisional Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 60.87 E-value: 2.17e-09
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| F-box_FBXO48 | cd22113 | F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called ... |
281-325 | 3.17e-09 | ||||||
F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438885 Cd Length: 46 Bit Score: 53.09 E-value: 3.17e-09
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| F-box_FBXW12 | cd22137 | F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; ... |
284-325 | 3.45e-09 | ||||||
F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438909 Cd Length: 44 Bit Score: 52.77 E-value: 3.45e-09
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| F-box_FBXL13 | cd22124 | F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also ... |
281-321 | 6.25e-09 | ||||||
F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also called F-box and leucine-rich repeat protein 13, or dynein regulatory complex subunit 6, is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. It is also the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438896 Cd Length: 42 Bit Score: 51.95 E-value: 6.25e-09
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| F-box_SF | cd09917 | F-box domain superfamily; This short domain is commonly found at the N-terminus of various ... |
282-316 | 1.18e-08 | ||||||
F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures. Pssm-ID: 438852 Cd Length: 35 Bit Score: 50.91 E-value: 1.18e-08
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| F-box_FBXO7 | cd22087 | F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called ... |
283-325 | 3.55e-08 | ||||||
F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called FBX7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes BIRC2 and DLGAP5. FBXO7 plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. It promotes MFN1 ubiquitination. FBXO7 acts as a cell cycle regulator by enhancing cyclin D/cyclin-dependent kinase 6 (Cdk6) complex formation and stabilizing levels of p27, a cyclin-dependent kinase inhibitor. Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism called parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438859 Cd Length: 45 Bit Score: 49.99 E-value: 3.55e-08
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| WD40 | COG2319 | WD40 repeat [General function prediction only]; |
546-692 | 4.95e-08 | ||||||
WD40 repeat [General function prediction only]; Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 55.69 E-value: 4.95e-08
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| F-box_FBXL4 | cd22117 | F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ... |
281-323 | 1.39e-07 | ||||||
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438889 Cd Length: 47 Bit Score: 48.39 E-value: 1.39e-07
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| F-box | pfam00646 | F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ... |
281-322 | 1.45e-07 | ||||||
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 425796 Cd Length: 43 Bit Score: 48.30 E-value: 1.45e-07
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| F-box_FBXL5 | cd22118 | F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also ... |
281-321 | 1.81e-07 | ||||||
F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438890 Cd Length: 41 Bit Score: 47.72 E-value: 1.81e-07
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| WD40 | smart00320 | WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
610-650 | 1.99e-07 | ||||||
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 47.69 E-value: 1.99e-07
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| WD40 | pfam00400 | WD domain, G-beta repeat; |
532-567 | 2.45e-07 | ||||||
WD domain, G-beta repeat; Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 47.34 E-value: 2.45e-07
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| F-box_FBXO3 | cd22084 | F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ... |
281-327 | 2.61e-07 | ||||||
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438856 Cd Length: 49 Bit Score: 47.64 E-value: 2.61e-07
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| F-box_FBXL2-like | cd22115 | F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) ... |
284-322 | 2.64e-07 | ||||||
F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) and similar proteins; The family includes FBXL2 and FBXL30. FBXL2, also called F-box and leucine-rich repeat protein 2, or F-box protein FBL2/FBL3, is a calcium-activated substrate-recognition component of an SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. FBXL20, also called SCRAPPER, F-box and leucine-rich repeat protein 20, or F-box/LRR-repeat protein 2-like, is a component of a synapse-localized SCF-type E3 ubiquitin ligase which regulates neural transmission. It is widely expressed in the central nervous system and plays an important role in the ubiquitin-dependent degradation of regulating synaptic membrane exocytosis 1 (RIM1), which is an important factor in the release of synaptic vesicles. It may also mediate the ubiquitin degradation of E-cadherin resulting in an increased invasive ability of malignant cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438887 Cd Length: 45 Bit Score: 47.41 E-value: 2.64e-07
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| WD40 | smart00320 | WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
530-567 | 2.64e-07 | ||||||
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 47.31 E-value: 2.64e-07
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| WD40 | smart00320 | WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
450-487 | 3.98e-07 | ||||||
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 46.92 E-value: 3.98e-07
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| F-box_AtSKIP31-like | cd22166 | F-box domain found in Arabidopsis thaliana SKP1-interacting partner 31 (AtSKIP31) and similar ... |
284-322 | 4.78e-07 | ||||||
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 31 (AtSKIP31) and similar proteins; AtSKIP31, also called F-box protein SKIP31, is a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438937 Cd Length: 46 Bit Score: 46.68 E-value: 4.78e-07
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| F-box_FBXL12 | cd22123 | F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ... |
281-322 | 4.79e-07 | ||||||
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438895 Cd Length: 42 Bit Score: 46.57 E-value: 4.79e-07
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| F-box_FBXO41 | cd22109 | F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called ... |
281-325 | 5.90e-07 | ||||||
F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438881 Cd Length: 47 Bit Score: 46.55 E-value: 5.90e-07
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| WD40 | pfam00400 | WD domain, G-beta repeat; |
611-650 | 6.53e-07 | ||||||
WD domain, G-beta repeat; Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 46.18 E-value: 6.53e-07
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| F-box_FBXL1 | cd22114 | F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also ... |
282-321 | 6.91e-07 | ||||||
F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438886 Cd Length: 41 Bit Score: 46.25 E-value: 6.91e-07
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| F-box_FBXW2 | cd22131 | F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, ... |
279-311 | 7.24e-07 | ||||||
F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438903 Cd Length: 40 Bit Score: 46.17 E-value: 7.24e-07
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| WD40 | pfam00400 | WD domain, G-beta repeat; |
451-487 | 9.67e-07 | ||||||
WD domain, G-beta repeat; Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 45.80 E-value: 9.67e-07
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| F-box_FBXW1 | cd22130 | F-box domain found in F-box/WD repeat-containing proteins, FBXW1A, FBXW1B and similar proteins; ... |
277-323 | 1.23e-06 | ||||||
F-box domain found in F-box/WD repeat-containing proteins, FBXW1A, FBXW1B and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438902 Cd Length: 51 Bit Score: 45.93 E-value: 1.23e-06
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| F-box_AtARP8-like | cd22156 | F-box domain found in Arabidopsis thaliana actin-related protein 8 (AtARP8) and similar ... |
284-321 | 1.28e-06 | ||||||
F-box domain found in Arabidopsis thaliana actin-related protein 8 (AtARP8) and similar proteins; AtARP8, also called F-box protein ARP8, is an F-box protein localized to the nucleolus in Arabidopsis. Unlike other plant nuclear actin-related proteins (ARPs), ARP8 is unique in having an F-box domain and an actin homology domain. It may play a role in nucleolar functions. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438927 Cd Length: 45 Bit Score: 45.45 E-value: 1.28e-06
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| FBOX | smart00256 | A Receptor for Ubiquitination Targets; |
284-324 | 1.29e-06 | ||||||
A Receptor for Ubiquitination Targets; Pssm-ID: 197608 Cd Length: 41 Bit Score: 45.51 E-value: 1.29e-06
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| F-box_FBXW1B | cd22183 | F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; ... |
277-323 | 1.99e-06 | ||||||
F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438954 Cd Length: 51 Bit Score: 45.28 E-value: 1.99e-06
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| F-box_FBXO17-like | cd22169 | F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and ... |
281-325 | 2.13e-06 | ||||||
F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and similar proteins; This subfamily includes FBXO17 and FBXO27. FBXO17 is also called FBX17, F-box only protein 26 (FBX26/FBXO26), or FBG4, while FBXO27 is also called FBX27, or F-box/G-domain protein 5. FBXO17 and FBXO27 are the substrate-recognition components of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. They can recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. FBXO17 also recognizes sulfated glycans but does not bind high-mannose glycoproteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438940 Cd Length: 48 Bit Score: 45.10 E-value: 2.13e-06
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| F-box_AtGID2-like | cd22151 | F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ... |
282-325 | 2.14e-06 | ||||||
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438922 Cd Length: 44 Bit Score: 45.00 E-value: 2.14e-06
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| F-box_FBXO31 | cd22102 | F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called ... |
284-328 | 2.46e-06 | ||||||
F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called FBX31, or FBXO14, is a component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438874 Cd Length: 48 Bit Score: 44.73 E-value: 2.46e-06
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| WD40 | smart00320 | WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
490-527 | 2.80e-06 | ||||||
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 44.61 E-value: 2.80e-06
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| F-box_AtSKIP22-like | cd22165 | F-box domain found in Arabidopsis thaliana SKP1-interacting partner 22 (AtSKIP22) and similar ... |
283-325 | 6.01e-06 | ||||||
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 22 (AtSKIP22) and similar proteins; AtSKIP22, also called F-box protein SKIP22, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438936 Cd Length: 46 Bit Score: 43.80 E-value: 6.01e-06
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| PTZ00421 | PTZ00421 | coronin; Provisional |
499-652 | 8.98e-06 | ||||||
coronin; Provisional Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 48.74 E-value: 8.98e-06
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| WD40 | smart00320 | WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
410-447 | 1.02e-05 | ||||||
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 42.68 E-value: 1.02e-05
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| F-box_FBXO15 | cd22093 | F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called ... |
281-326 | 1.15e-05 | ||||||
F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438865 Cd Length: 46 Bit Score: 43.01 E-value: 1.15e-05
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| F-box_FBXO11 | cd22091 | F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called ... |
284-322 | 1.29e-05 | ||||||
F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438863 Cd Length: 45 Bit Score: 42.79 E-value: 1.29e-05
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| WD40 | pfam00400 | WD domain, G-beta repeat; |
491-527 | 1.38e-05 | ||||||
WD domain, G-beta repeat; Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 42.33 E-value: 1.38e-05
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| F-box_FBXO8 | cd22088 | F-box domain found in F-box only protein 8 (FBXO8) and similar proteins; FBXO8, also called ... |
281-326 | 1.44e-05 | ||||||
F-box domain found in F-box only protein 8 (FBXO8) and similar proteins; FBXO8, also called FBX8, or F-box/SEC7 protein FBS, is a novel component of F-box proteins which contains an F-box domain and a putative Sec7 domain. FBX8 was originally identified as a Skp1-binding protein. It is involved in the ubiquitin-dependent proteolytic pathway. It acts as a metastasis suppressor that functions through mTOR signaling pathway. FBXO8 may promote the activation of ADP-ribosylation factor (ARF) through replacement of GDP with GTP. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438860 Cd Length: 46 Bit Score: 42.70 E-value: 1.44e-05
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| F-box_FBXO33 | cd22104 | F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called ... |
282-312 | 2.16e-05 | ||||||
F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438876 Cd Length: 48 Bit Score: 42.24 E-value: 2.16e-05
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| WD40 | pfam00400 | WD domain, G-beta repeat; |
411-447 | 3.31e-05 | ||||||
WD domain, G-beta repeat; Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 41.56 E-value: 3.31e-05
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| F-box_FBXO6-like | cd22168 | F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily ... |
281-329 | 3.39e-05 | ||||||
F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438939 [Multi-domain] Cd Length: 82 Bit Score: 42.66 E-value: 3.39e-05
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| F-box_FBXO36 | cd22106 | F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called ... |
284-322 | 5.01e-05 | ||||||
F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called FBX36, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438878 Cd Length: 46 Bit Score: 41.02 E-value: 5.01e-05
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| F-box_ScMFB1-like | cd22146 | F-box domain found in Saccharomyces cerevisiae mitochondrial F-box protein MFB1 (ScMFB1) and ... |
284-322 | 6.22e-05 | ||||||
F-box domain found in Saccharomyces cerevisiae mitochondrial F-box protein MFB1 (ScMFB1) and similar proteins; ScMFB1 is a novel mitochondria-associated F-box protein that functions to increase mitochondrial connectivity in yeast. ScMFB1 acts as a key component of a Skp1-Cdc53/Cullin-F-box protein (SCF) ubiquitin ligase complex machinery that regulates mitochondrial dynamics throughout the yeast's entire life cycle. It interacts with Skp1p in an F-box-dependent manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438917 Cd Length: 42 Bit Score: 40.70 E-value: 6.22e-05
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| WD40 | smart00320 | WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
374-407 | 6.30e-05 | ||||||
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 40.76 E-value: 6.30e-05
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| F-box_unchar | cd22138 | F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 ... |
282-323 | 6.33e-05 | ||||||
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 (FBXO13); The family corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 13 (FBXO13). FBXO13, also called FBX13, or F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438910 Cd Length: 45 Bit Score: 40.78 E-value: 6.33e-05
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| F-box_FBXO24 | cd22098 | F-box domain found in F-box only protein 24 (FBXO24) and similar proteins; FBXO24, also called ... |
284-326 | 7.36e-05 | ||||||
F-box domain found in F-box only protein 24 (FBXO24) and similar proteins; FBXO24, also called FBX24, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It recognizes deacetylated nucleoside diphosphate kinase A (NDPK-A) to enhance its degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438870 Cd Length: 47 Bit Score: 40.77 E-value: 7.36e-05
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| F-box_FBXO21 | cd22096 | F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called ... |
281-324 | 1.11e-04 | ||||||
F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called FBX21, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It facilitates Lys29-linkage and activation of ASK1 (apoptosis signal-regulating kinase 1) and promotes type I interferon production upon viral infection. It also polyubiquitylates EP300-interacting inhibitor of differentiation 1 (EID1) and is required for the efficient degradation of EID1 in both cycling and quiescent cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438868 Cd Length: 48 Bit Score: 39.98 E-value: 1.11e-04
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| F-box_FBXO9 | cd22089 | F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called ... |
280-325 | 1.34e-04 | ||||||
F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called FBX9, cross-immune reaction antigen 1, renal carcinoma antigen NY-REN-57, or VCIA1, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. FBXO9 acts as an E3 ubiquitin ligase that regulates the stability and activity of peroxisome proliferator-activated receptor gamma (PPARgamma) through ubiquitination. It is also required for adipocyte differentiation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438861 Cd Length: 53 Bit Score: 39.90 E-value: 1.34e-04
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| F-box_FBXW10 | cd22136 | F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; ... |
280-316 | 1.70e-04 | ||||||
F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; FBXW10, also called F-box and WD-40 domain-containing protein 10, or ubiquitin ligase-specificity factor, is a probable substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Its overexpression leads to degradation of CBX5 and CBX1. FBXW10 is negatively regulated in transcription and expression levels by protein O-GlcNAcylation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438908 Cd Length: 40 Bit Score: 39.54 E-value: 1.70e-04
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| YncE | COG3391 | DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
555-692 | 2.39e-04 | ||||||
DNA-binding beta-propeller fold protein YncE [General function prediction only]; Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 43.14 E-value: 2.39e-04
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| WD40 | pfam00400 | WD domain, G-beta repeat; |
374-407 | 3.14e-04 | ||||||
WD domain, G-beta repeat; Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 38.48 E-value: 3.14e-04
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| PTZ00421 | PTZ00421 | coronin; Provisional |
473-657 | 4.56e-04 | ||||||
coronin; Provisional Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 43.34 E-value: 4.56e-04
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| F-box_FBXW4 | cd20090 | F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, ... |
284-323 | 4.85e-04 | ||||||
F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, also called dactylin, or F-box and WD-40 domain-containing protein 4, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is likely to be involved in key signaling pathways crucial for normal limb development. It may participate in Wnt signaling and act as a novel tumor suppressor that regulates important cellular processes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438853 Cd Length: 47 Bit Score: 38.35 E-value: 4.85e-04
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| F-box_FBXW1A | cd22182 | F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; ... |
276-323 | 5.31e-04 | ||||||
F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438953 Cd Length: 60 Bit Score: 38.51 E-value: 5.31e-04
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| PLN00181 | PLN00181 | protein SPA1-RELATED; Provisional |
537-662 | 5.64e-04 | ||||||
protein SPA1-RELATED; Provisional Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 43.15 E-value: 5.64e-04
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| F-box_FBXO42 | cd22110 | F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ... |
281-317 | 6.10e-04 | ||||||
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438882 Cd Length: 38 Bit Score: 37.70 E-value: 6.10e-04
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| WD40 | smart00320 | WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
570-607 | 6.29e-04 | ||||||
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 37.68 E-value: 6.29e-04
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| Nsa1_WDR74-like | cd22850 | Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ... |
447-495 | 9.59e-04 | ||||||
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization. Pssm-ID: 439302 [Multi-domain] Cd Length: 333 Bit Score: 41.85 E-value: 9.59e-04
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| F-box_FBXO10 | cd22090 | F-box domain found in F-box only protein 10 (FBXO10) and similar proteins; FBXO10, also called ... |
281-325 | 1.74e-03 | ||||||
F-box domain found in F-box only protein 10 (FBXO10) and similar proteins; FBXO10, also called FBX10, or PRMT11, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an anti-apoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. It also associates with the receptor for advanced glycation end products (RAGE) to mediate its ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438862 Cd Length: 50 Bit Score: 36.95 E-value: 1.74e-03
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| F-box_D3-like | cd22140 | F-box domain found in Oryza sativa F-box/LRR-repeat Max2 homolog (D3) and similar proteins; D3 ... |
284-318 | 2.64e-03 | ||||||
F-box domain found in Oryza sativa F-box/LRR-repeat Max2 homolog (D3) and similar proteins; D3 is the ortholog of Arabidopsis MORE AXILLARY GROWTH2 (MAX2) and DWARF14 (AtD14) in rice. These proteins are essential signaling components to regulate strigolactone (SL)-repressed plant branching. In rice shoot branching inhibition, the SL-metabolizing alpha/beta hydrolase D14 interacts with the F-box protein D3 to ubiquitinate and degrade the transcription repressor D53. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438912 Cd Length: 38 Bit Score: 36.19 E-value: 2.64e-03
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| F-box_AtSKIP5-like | cd22163 | F-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar ... |
281-321 | 3.49e-03 | ||||||
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar proteins; AtSKIP5, also called F-box protein SKIP5, is a component of SCF (SKP1-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438934 Cd Length: 46 Bit Score: 35.78 E-value: 3.49e-03
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| F-box_FBXW9 | cd22135 | F-box domain found in F-box/WD repeat-containing protein 9 (FBXW9) and similar proteins; FBXW9, ... |
284-324 | 3.75e-03 | ||||||
F-box domain found in F-box/WD repeat-containing protein 9 (FBXW9) and similar proteins; FBXW9, also called F-box and WD-40 domain-containing protein 9, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438907 Cd Length: 45 Bit Score: 35.72 E-value: 3.75e-03
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| WD40 | pfam00400 | WD domain, G-beta repeat; |
571-607 | 5.10e-03 | ||||||
WD domain, G-beta repeat; Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 35.40 E-value: 5.10e-03
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| F-box_DmSKP2-like | cd22149 | F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and ... |
284-322 | 5.16e-03 | ||||||
F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438920 Cd Length: 43 Bit Score: 35.43 E-value: 5.16e-03
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