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Conserved domains on  [gi|2217356764|ref|XP_047273477|]
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cyclin-I2 isoform X1 [Homo sapiens]

Protein Classification

cyclin family protein( domain architecture ID 1750054)

cyclin family protein may associate with and activate its cognate cyclin-dependent kinase (CDK)

CATH:  1.10.472.10
Gene Ontology:  GO:0000079|GO:0019901|GO:0007049
PubMed:  14744433|30185601|15269391|15840440
SCOP:  4001102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 151-247 1.19e-33

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20526:

Pssm-ID: 477360  Cd Length: 99  Bit Score: 118.57  E-value: 1.19e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 151 EEVVLWLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVNEEEEFIPQVKDFTKHYGSDYSPN 230
Cdd:cd20526     3 DEAVRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTNEEDEVIPSTKDLVRVSKCGCSVA 82

                          90
                  ....*....|....*..
gi 2217356764 231 ELLRMELAILDRLHWDL 247
Cdd:cd20526    83 EVLRMERIILDKLHWDL 99
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
3-111 2.41e-05

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 45.64  E-value: 2.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764   3 SGAQLPPQPSSSEVSAVQSPGGRPGAGLEETALGVPLPPSPGEAPLPRSNRSRCPGTRQPGAASLHAASAAVPVRPRRGT 82
Cdd:PRK12323  369 GGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAP 448

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2217356764  83 APAGKT----ADAVPAAAPEQAPRPAPQSRKPR 111
Cdd:PRK12323  449 APAPAPaaapAAAARPAAAGPRPVAAAAAAAPA 481
 
Name Accession Description Interval E-value
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 151-247 1.19e-33

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 118.57  E-value: 1.19e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 151 EEVVLWLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVNEEEEFIPQVKDFTKHYGSDYSPN 230
Cdd:cd20526     3 DEAVRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTNEEDEVIPSTKDLVRVSKCGCSVA 82

                          90
                  ....*....|....*..
gi 2217356764 231 ELLRMELAILDRLHWDL 247
Cdd:cd20526    83 EVLRMERIILDKLHWDL 99
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 156-247 1.86e-17

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 76.79  E-value: 1.86e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 156 WLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVneEEEFIPQVKDFTkhYGSD--YSPNELL 233
Cdd:pfam00134  37 WLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKY--EEIYPPTVEDLV--YITDnaYTREEIL 112

                          90
                  ....*....|....
gi 2217356764 234 RMELAILDRLHWDL 247
Cdd:pfam00134 113 RMERLILETLNFDL 126
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 156-241 2.14e-09

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 53.37  E-value: 2.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764  156 WLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVneeEEFIPQVKDFTKHYGsDYSPNELLRM 235
Cdd:smart00385   2 FLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKT---EETPPWTKELVHYTG-YFTEEEILRM 77


                   ....*.
gi 2217356764  236 ELAILD 241
Cdd:smart00385  78 ERLLLE 83
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
150-272 8.61e-09

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 55.94  E-value: 8.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 150 FEEVVLWLLRLQNTFYFSQSTFNLALTIFGRLLISVKVK-EKYLHCAtITSLRLAAKVneEEEFIPQVKDFTKHYGSDYS 228
Cdd:COG5024   213 RSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSlEKYQLVG-ISALFIASKY--EEVNCPSIKDLVYATDGAFT 289

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2217356764 229 PNELLRMELAILDRLHWDLYIGTPLDFLTIVSK----EVFTEsTLNSF 272
Cdd:COG5024   290 RDDIIRAERYMLEVLDFNISWPSPMSFLRRISKasdyDIFSR-TPAKF 336
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
3-111 2.41e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.64  E-value: 2.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764   3 SGAQLPPQPSSSEVSAVQSPGGRPGAGLEETALGVPLPPSPGEAPLPRSNRSRCPGTRQPGAASLHAASAAVPVRPRRGT 82
Cdd:PRK12323  369 GGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAP 448

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2217356764  83 APAGKT----ADAVPAAAPEQAPRPAPQSRKPR 111
Cdd:PRK12323  449 APAPAPaaapAAAARPAAAGPRPVAAAAAAAPA 481
 
Name Accession Description Interval E-value
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 151-247 1.19e-33

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 118.57  E-value: 1.19e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 151 EEVVLWLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVNEEEEFIPQVKDFTKHYGSDYSPN 230
Cdd:cd20526     3 DEAVRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTNEEDEVIPSTKDLVRVSKCGCSVA 82

                          90
                  ....*....|....*..
gi 2217356764 231 ELLRMELAILDRLHWDL 247
Cdd:cd20526    83 EVLRMERIILDKLHWDL 99
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 156-247 1.86e-17

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 76.79  E-value: 1.86e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 156 WLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVneEEEFIPQVKDFTkhYGSD--YSPNELL 233
Cdd:pfam00134  37 WLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKY--EEIYPPTVEDLV--YITDnaYTREEIL 112

                          90
                  ....*....|....
gi 2217356764 234 RMELAILDRLHWDL 247
Cdd:pfam00134 113 RMERLILETLNFDL 126
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 158-243 6.39e-17

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 74.31  E-value: 6.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 158 LRLQNTFY-FSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVNEEEEFIPQVKDFTKHYGSDYSPNELLRME 236
Cdd:cd20523     8 LRCLHRFYgFSPETFALAVNLLDRFLSKVKVKPKHLACITVSCFHIAIKSVEEDQNIPSAEDLIRISQCGCTAADLMRME 87


                  ....*..
gi 2217356764 237 LAILDRL 243
Cdd:cd20523    88 GIILEKL 94
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 157-244 3.66e-13

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 64.10  E-value: 3.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 157 LLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVNEEEEFIPQVKDFTKHYGSDYSPNELLRME 236
Cdd:cd20584     9 LWSLTNFFGFSTETFVLAVNILDRFLALMKVKPKHLSCIGICCFHLAARVVEEECNIPSSHDLIRISQCKCTVSDLKRME 88


                  ....*...
gi 2217356764 237 LAILDRLH 244
Cdd:cd20584    89 KIISEKLH 96
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 157-245 1.90e-12

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 62.15  E-value: 1.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 157 LLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVNEEEEFIPQVKDFTKHYGSDYSPNELLRME 236
Cdd:cd20583     9 LLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAIEEERNVPLATDLIRISQYRFTVSDMMRME 88


                  ....*....
gi 2217356764 237 LAILDRLHW 245
Cdd:cd20583    89 KIILEKLCW 97
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 151-245 1.12e-11

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 60.31  E-value: 1.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 151 EEVVLWLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVNEEEEFIPQVKDFTKHYGSD-YSP 229
Cdd:cd20528     8 RYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELDDNIPKISDLNRYLCNSvYSK 87

                          90
                  ....*....|....*.
gi 2217356764 230 NELLRMELAILDRLHW 245
Cdd:cd20528    88 QEYLQMELLILEFFQW 103
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 156-244 4.71e-11

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 59.47  E-value: 4.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 156 WLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVneEEEFIPQVKDFTkhYGSD--YSPNELL 233
Cdd:cd20507    43 WLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQLVGVTALLIASKY--EEIYPPEIKDFV--YITDnaYTREEIL 118

                          90
                  ....*....|.
gi 2217356764 234 RMELAILDRLH 244
Cdd:cd20507   119 QMERDILKTLD 129
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 153-247 1.10e-09

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 54.63  E-value: 1.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 153 VVLWLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVneEEEFIPQVKDFTKHYGSDYSPNEL 232
Cdd:cd20542     4 LVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKF--EERFPPEVATLCYLTDDSYSKKQV 81

                          90
                  ....*....|....*
gi 2217356764 233 LRMELAILDRLHWDL 247
Cdd:cd20542    82 LRMERRVLRRLRFDL 96
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 156-241 2.14e-09

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 53.37  E-value: 2.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764  156 WLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVneeEEFIPQVKDFTKHYGsDYSPNELLRM 235
Cdd:smart00385   2 FLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKT---EETPPWTKELVHYTG-YFTEEEILRM 77


                   ....*.
gi 2217356764  236 ELAILD 241
Cdd:smart00385  78 ERLLLE 83
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 152-246 4.71e-09

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 52.77  E-value: 4.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 152 EVVLWLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVNEEEEFIPQVKDFTKHYGSDYSPNE 231
Cdd:cd20559     1 ALLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKARVPLLSELSKMCCNSYGEEL 80

                          90
                  ....*....|....*
gi 2217356764 232 LLRMELAILDRLHWD 246
Cdd:cd20559    81 FIQMEMHILNTLNWD 95
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
150-272 8.61e-09

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 55.94  E-value: 8.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 150 FEEVVLWLLRLQNTFYFSQSTFNLALTIFGRLLISVKVK-EKYLHCAtITSLRLAAKVneEEEFIPQVKDFTKHYGSDYS 228
Cdd:COG5024   213 RSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSlEKYQLVG-ISALFIASKY--EEVNCPSIKDLVYATDGAFT 289

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2217356764 229 PNELLRMELAILDRLHWDLYIGTPLDFLTIVSK----EVFTEsTLNSF 272
Cdd:COG5024   290 RDDIIRAERYMLEVLDFNISWPSPMSFLRRISKasdyDIFSR-TPAKF 336
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 153-245 2.51e-08

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 51.79  E-value: 2.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 153 VVLWLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVneEEEFIPQVKDFTKHYGSDYSPNEL 232
Cdd:cd20566    43 LVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRKKLQLVGVTALLLASKY--EEMYSPEIGDFVYITDNAYTKAQI 120

                          90
                  ....*....|...
gi 2217356764 233 LRMELAILDRLHW 245
Cdd:cd20566   121 REMEMLILKELNF 133
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 152-237 5.82e-08

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 49.33  E-value: 5.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 152 EVVLWLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVneeEEFIPQVKDFTKHygSDYSPNE 231
Cdd:cd00043     1 KAVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKL---EELPRTLKEIAKV--SGVSEKE 75


                  ....*.
gi 2217356764 232 LLRMEL 237
Cdd:cd00043    76 LRKAEK 81
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 156-245 1.15e-07

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 49.85  E-value: 1.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 156 WLLRLQNTFYFSQSTFNLALTIFGRLLISVK-VKEKYLHCATITSLRLAAKVneEEEFIPQVKDFTKHYGSDYSPNELLR 234
Cdd:cd20580    49 WLLEVCEVYTLHRETFYLAQDFFDRFMLTQKnINKSMLQLIGITSLFIASKL--EEIYPPKLHEFAYVTDGACSEDDILD 126

                          90
                  ....*....|.
gi 2217356764 235 MELAILDRLHW 245
Cdd:cd20580   127 MELIILKALKW 137
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 151-245 1.72e-07

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 48.47  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 151 EEVVLWLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITS---LRLAAKVneEEEFIPQVKDF----TKHy 223
Cdd:cd20543     3 NEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKPWMLQLLAvacLSLAAKM--EETDVPLLVDLqveePKY- 79

                          90       100
                  ....*....|....*....|..
gi 2217356764 224 gsDYSPNELLRMELAILDRLHW 245
Cdd:cd20543    80 --VFEAKTIQRMELLVLSTLEW 99
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 156-243 2.27e-06

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 46.02  E-value: 2.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 156 WLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVneEEEFIPQVKDFTKHYGSDYSPNELLRM 235
Cdd:cd20565    42 WLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQLVGVTAMFIASKY--EEMYPPEIGDFAFVTDNTYTKHQIRQM 119


                  ....*...
gi 2217356764 236 ELAILDRL 243
Cdd:cd20565   120 EMKILRAL 127
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 156-245 2.63e-06

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 45.77  E-value: 2.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 156 WLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKY-LHCATITSLRLAAKVneEEEFIPQVKDFTKHYGSDYSPNELLR 234
Cdd:cd20519    43 WLMEVCEVYRLHRETFYLAVDFVDRYLSTQTNVPKTqLQLIGITCLFIAAKL--EEIYPPKLSEFAYVTDGACTEDEILT 120

                          90
                  ....*....|.
gi 2217356764 235 MELAILDRLHW 245
Cdd:cd20519   121 MELIILKALNW 131
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 141-246 3.78e-06

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 45.43  E-value: 3.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 141 KPQDEICDAFEEVVL-WLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVneEEEFIPQVKDF 219
Cdd:cd20561    27 KKQPDITNSMRAILVdWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKF--EEIYPPEVAEF 104

                          90       100
                  ....*....|....*....|....*..
gi 2217356764 220 TKHYGSDYSPNELLRMELAILDRLHWD 246
Cdd:cd20561   105 VYITDDTYTKKQVLRMEHLVLKVLTFD 131
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
3-111 2.41e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.64  E-value: 2.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764   3 SGAQLPPQPSSSEVSAVQSPGGRPGAGLEETALGVPLPPSPGEAPLPRSNRSRCPGTRQPGAASLHAASAAVPVRPRRGT 82
Cdd:PRK12323  369 GGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAP 448

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2217356764  83 APAGKT----ADAVPAAAPEQAPRPAPQSRKPR 111
Cdd:PRK12323  449 APAPAPaaapAAAARPAAAGPRPVAAAAAAAPA 481
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 156-245 4.49e-05

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 42.56  E-value: 4.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 156 WLLRLQNTFYFSQSTFNLALTIFGRLLISVK-VKEKYLHCATITSLRLAAKVneEEEFIPQVKDFTKHYGSDYSPNELLR 234
Cdd:cd20579    49 WLMEVCEVYKLHRETFYLAQDFFDRFMATQEnVVKTRLQLIGISSLFIAAKL--EEIYPPKLHQFAYVTDGACTEDEILS 126

                          90
                  ....*....|.
gi 2217356764 235 MELAILDRLHW 245
Cdd:cd20579   127 MELIIMKALKW 137
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 154-246 4.86e-05

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 42.63  E-value: 4.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 154 VLWLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVneEEEFIPQVKDFTkhYGSD--YSPNE 231
Cdd:cd20508    52 VDWLVEVQENFELNHETLYLAVKLVDLYLSKKVVKKEKLQLLGATAILIASKF--DERCPPCVDDFL--YICDdaYTREE 127

                          90
                  ....*....|....*
gi 2217356764 232 LLRMELAILDRLHWD 246
Cdd:cd20508   128 LLKMEREILKTLDFD 142
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 143-246 6.77e-05

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 42.27  E-value: 6.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 143 QDEICDAFEEVV-LWLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVNEEeefIPQVKDFTK 221
Cdd:cd20573    47 QKEILPSMRKIVaTWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGATCMFLASKMKET---IPLTAEKLC 123

                          90       100
                  ....*....|....*....|....*..
gi 2217356764 222 HYgSDYS--PNELLRMELAILDRLHWD 246
Cdd:cd20573   124 IY-TDNSirPEELLQMELLVLNKLKWD 149
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 154-246 7.26e-05

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 42.01  E-value: 7.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 154 VLWLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVneEEEFIPQVKDFTKHYGSDYSPNELL 233
Cdd:cd20562    46 VDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVNRQRLQLLGVSCMLIASKY--EEICAPQVEEFCYITDNTYTKQEVL 123

                          90
                  ....*....|...
gi 2217356764 234 RMELAILDRLHWD 246
Cdd:cd20562   124 EMEIDVLNALQFE 136
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 114-247 1.30e-04

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 41.43  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 114 EGDLDERRLLCHLQLAQDREARLWRGGKPQDEICDAFEEVVL--WLLRLQ---NTFYFSQSTFNLALTIFGRLlisvkvk 188
Cdd:cd20524    14 EEELAELRAEANEKAREKLKESLKEEDAEPKFLTPEEELLLVryYEKKLLefcRAFKLPDSVLATALTYFKRF------- 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217356764 189 ekYLHCAT---------ITSLRLAAKVneeEEFIPQVKDFTKHY-GSDYSPNELLRMELAILDRLHWDL 247
Cdd:cd20524    87 --YLKNSVmeyhpkeimLTCLYLACKV---EEFNISIDQFVGNIkESEKTAEIILEYELLLLQGLNFHL 150
PHA03247 PHA03247
large tegument protein UL36; Provisional
 5-110 1.65e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 1.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764    5 AQLPPQPSSSEVSAVQSPGGRPGAGLEETALGVPLPPSPGEAPLPRSNRSRCPGTRQPGAASLHAASAAVPVRPRRGTAP 84
Cdd:PHA03247  2610 GPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAAR 2689

                           90       100
                   ....*....|....*....|....*...
gi 2217356764   85 A--GKTADAVPAAAPEQAPRPAPQSRKP 110
Cdd:PHA03247  2690 PtvGSLTSLADPPPPPPTPEPAPHALVS 2717
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 8-106 2.59e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.20  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764   8 PPQPSSSEVSAVQSPGGRPGAGLEETALGVPLPPSPGEAPLPRSnRSRCPGTRQPGAASLHAASAAVPVRPRRGTAPAGK 87
Cdd:PRK07764  615 PAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVA-VPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAP 693

                          90
                  ....*....|....*....
gi 2217356764  88 TADAVPAAAPEQAPRPAPQ 106
Cdd:PRK07764  694 AGAAPAQPAPAPAATPPAG 712
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 132-246 2.97e-03

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 37.51  E-value: 2.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764 132 REARLWRGGKP-----QDEICDAFEEV-VLWLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAK 205
Cdd:cd20560    45 REAELKHRPKPgymrkQPDITTGMRTIlVDWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSVLRGKLQLVGTAAILLASK 124

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2217356764 206 VneEEEFIPQVKDFTKHYGSDYSPNELLRMELAILDRLHWD 246
Cdd:cd20560   125 Y--EEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVLAFD 163
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1-107 3.52e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 38.81  E-value: 3.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764   1 MASGAQLPPQPSSSEVSAVQSPGGRPGAGLEETALGVPLPPSPGEAPLPRSnrsrcpgTRQPGAASLHAASAAVPVRPRR 80
Cdd:PRK07764  387 VAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAP-------APAPPSPAGNAPAGGAPSPPPA 459

                          90       100
                  ....*....|....*....|....*..
gi 2217356764  81 GTAPAgkTADAVPAAAPEQAPRPAPQS 107
Cdd:PRK07764  460 AAPSA--QPAPAPAAAPEPTAAPAPAP 484
PHA03247 PHA03247
large tegument protein UL36; Provisional
 4-114 6.14e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.38  E-value: 6.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764    4 GAQLPPQPSSSEVSAVQSPGGRPGA---------------GLEETA---LGVPLPPSPGEAPLPRSNRS---RCPGTRQP 62
Cdd:PHA03247  2499 GGGGPPDPDAPPAPSRLAPAILPDEpvgepvhprmltwirGLEELAsddAGDPPPPLPPAAPPAAPDRSvppPRPAPRPS 2578

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217356764   63 GAASLHAASA-AVPVRPRRGTAPAGKTAD----AVPAAAP--EQAPRPAPQSRKPRNLE 114
Cdd:PHA03247  2579 EPAVTSRARRpDAPPQSARPRAPVDDRGDprgpAPPSPLPpdTHAPDPPPPSPSPAANE 2637
PHA03247 PHA03247
large tegument protein UL36; Provisional
 3-118 6.52e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.38  E-value: 6.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764    3 SGAQLPPQPSSSEVSAVQSPGGR--PGAGLEETALGVPLPPSPGEAPLPRSNRSRCPGTRQPGAASLHAASAavPVRPRR 80
Cdd:PHA03247  2833 SAQPTAPPPPPGPPPPSLPLGGSvaPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQ--PERPPQ 2910

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2217356764   81 GTAPAGKTADAVPAAAPEQAPRPAPQSRKPRNLEGDLD 118
Cdd:PHA03247  2911 PQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 25-106 7.57e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 37.77  E-value: 7.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356764  25 RPGAGLEET------ALGVPLPPSPGEAPLPRSNRSRCPGTRQPGaaslhAASAAVPVRPRRGTAPAGKTADAVPAAAPE 98
Cdd:PRK14951  365 KPAAAAEAAapaekkTPARPEAAAPAAAPVAQAAAAPAPAAAPAA-----AASAPAAPPAAAPPAPVAAPAAAAPAAAPA 439


                  ....*...
gi 2217356764  99 QAPRPAPQ 106
Cdd:PRK14951  440 AAPAAVAL 447
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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