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Conserved domains on  [gi|2217268661|ref|XP_047279906|]
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volume-regulated anion channel subunit LRRC8D isoform X1 [Homo sapiens]

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 12117038)

Pannexin_like and LRR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-384 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 623.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661   1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPVNSKAHtppgnaevttnip 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASL------------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661  81 kmeaatnqdqDGRTTNDISFGTSAVTPDIPLRATYPrtdfalpnqeakkekkDPTGRKTNLDFQQYVFINQMCYHLALPW 160
Cdd:pfam12534  68 ----------DDSYANSLSPTQSAPTVSSPSASMIP----------------EPKGRKTNLDRQQYVFINQVCYEKALHW 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 161 YSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKhVST 240
Cdd:pfam12534 122 YSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPK-VSS 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPS-MTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTVIKTAKF 319
Cdd:pfam12534 201 SSSLSSSDESAPLTRTPSVKSSPEKPVVEVPStVSVLDKKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKF 280

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217268661 320 IFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTL 384
Cdd:pfam12534 281 LLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
558-851 5.41e-41

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 155.86  E-value: 5.41e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 558 LLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNV 637
Cdd:COG4886    19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 638 AELELQNCEleriphAIFSLSNLQELDLKSNNIRTIEEIISfqHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNK 717
Cdd:COG4886    99 TELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELA--NLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQ 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 718 LESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEkVGQL 797
Cdd:COG4886   171 LTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNL 249

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217268661 798 SQLTQLELKGNCLDRLPAqLGQCRMLKKsgLVVEDHLFDTLPLEVKEALNQDIN 851
Cdd:COG4886   250 TNLEELDLSNNQLTDLPP-LANLTNLKT--LDLSNNQLTDLKLKELELLLGLNS 300
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-384 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 623.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661   1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPVNSKAHtppgnaevttnip 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASL------------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661  81 kmeaatnqdqDGRTTNDISFGTSAVTPDIPLRATYPrtdfalpnqeakkekkDPTGRKTNLDFQQYVFINQMCYHLALPW 160
Cdd:pfam12534  68 ----------DDSYANSLSPTQSAPTVSSPSASMIP----------------EPKGRKTNLDRQQYVFINQVCYEKALHW 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 161 YSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKhVST 240
Cdd:pfam12534 122 YSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPK-VSS 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPS-MTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTVIKTAKF 319
Cdd:pfam12534 201 SSSLSSSDESAPLTRTPSVKSSPEKPVVEVPStVSVLDKKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKF 280

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217268661 320 IFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTL 384
Cdd:pfam12534 281 LLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
558-851 5.41e-41

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 155.86  E-value: 5.41e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 558 LLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNV 637
Cdd:COG4886    19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 638 AELELQNCEleriphAIFSLSNLQELDLKSNNIRTIEEIISfqHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNK 717
Cdd:COG4886    99 TELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELA--NLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQ 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 718 LESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEkVGQL 797
Cdd:COG4886   171 LTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNL 249

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217268661 798 SQLTQLELKGNCLDRLPAqLGQCRMLKKsgLVVEDHLFDTLPLEVKEALNQDIN 851
Cdd:COG4886   250 TNLEELDLSNNQLTDLPP-LANLTNLKT--LDLSNNQLTDLKLKELELLLGLNS 300
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 590-841 4.76e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 82.97  E-value: 4.76e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 590 LKILHVKSNLT--KVPSNITDvaphLTKLVIHNDGTKLLV---LNSLKKMMNVAELELQNCELE-RIPHAIFSLSNLQEL 663
Cdd:PLN00113  166 LKVLDLGGNVLvgKIPNSLTN----LTSLEFLTLASNQLVgqiPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHL 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 664 DLKSNNIrTIEEIISFQHLKRLTCLKLWHNKIV-TIPPSITHVKNLESLYFSNNKLE-SLPVAVFSLQKLRCLDVSYNNI 741
Cdd:PLN00113  242 DLVYNNL-TGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNF 320

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 742 S-MIPIEIGLLQNLQHLHITGNKVD-ILPKQLFKCIKLRTLNLGQNCITS-LPEKVGQLSQLTQLELKGNCLD-RLPAQL 817
Cdd:PLN00113  321 TgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEgEIPKSL 400

                         250       260
                  ....*....|....*....|....
gi 2217268661 818 GQCRMLKKSGLvVEDHLFDTLPLE 841
Cdd:PLN00113  401 GACRSLRRVRL-QDNSFSGELPSE 423
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 640-814 6.99e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.52  E-value: 6.99e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 640 LELQNCELERIPhAIFSLSNLQELDLKSNNIRTIEeiiSFQHLKRLTCLKLWHNKIVTIPPsITHVKNLESLYFSNNK-- 717
Cdd:cd21340     7 LYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRis 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 718 -LESLPvavfSLQKLRCLDVSYNNI-----------SMIpieiGLLQNLQHLHITGNKVDILpKQLFKCIKLRTLNLGQN 785
Cdd:cd21340    82 vVEGLE----NLTNLEELHIENQRLppgekltfdprSLA----ALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNN 152

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2217268661 786 CITSLPE---KVGQLSQLTQLELKGNCLDRLP 814
Cdd:cd21340   153 QISDLEElldLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
636-695 1.56e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.56e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217268661 636 NVAELELQNCELERI-PHAIFSLSNLQELDLKSNNIRTIEEiISFQHLKRLTCLKLWHNKI 695
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-384 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 623.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661   1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPVNSKAHtppgnaevttnip 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASL------------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661  81 kmeaatnqdqDGRTTNDISFGTSAVTPDIPLRATYPrtdfalpnqeakkekkDPTGRKTNLDFQQYVFINQMCYHLALPW 160
Cdd:pfam12534  68 ----------DDSYANSLSPTQSAPTVSSPSASMIP----------------EPKGRKTNLDRQQYVFINQVCYEKALHW 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 161 YSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKhVST 240
Cdd:pfam12534 122 YSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPK-VSS 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPS-MTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTVIKTAKF 319
Cdd:pfam12534 201 SSSLSSSDESAPLTRTPSVKSSPEKPVVEVPStVSVLDKKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKF 280

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217268661 320 IFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTL 384
Cdd:pfam12534 281 LLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
558-851 5.41e-41

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 155.86  E-value: 5.41e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 558 LLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNV 637
Cdd:COG4886    19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 638 AELELQNCEleriphAIFSLSNLQELDLKSNNIRTIEEIISfqHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNK 717
Cdd:COG4886    99 TELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELA--NLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQ 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 718 LESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEkVGQL 797
Cdd:COG4886   171 LTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNL 249

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217268661 798 SQLTQLELKGNCLDRLPAqLGQCRMLKKsgLVVEDHLFDTLPLEVKEALNQDIN 851
Cdd:COG4886   250 TNLEELDLSNNQLTDLPP-LANLTNLKT--LDLSNNQLTDLKLKELELLLGLNS 300
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
546-813 9.38e-39

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 149.31  E-value: 9.38e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 546 FTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVApHLTKLVIHNdgtkl 625
Cdd:COG4886    32 LLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLT-NLTELDLSG----- 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 626 lvLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEiiSFQHLKRLTCLKLWHNKIVTIPPSITHV 705
Cdd:COG4886   106 --NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLDLSNNQLTDLPEELGNL 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 706 KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPkQLFKCIKLRTLNLGQN 785
Cdd:COG4886   182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNN 260

                         250       260
                  ....*....|....*....|....*...
gi 2217268661 786 CITSLPEkVGQLSQLTQLELKGNCLDRL 813
Cdd:COG4886   261 QLTDLPP-LANLTNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
561-825 1.07e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.45  E-value: 1.07e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 561 NLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKmmNVAEL 640
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLL--LLLLS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 641 ELQNCELERIPHAIFSLSNLQELDLKSNNirtieeiiSFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
Cdd:COG4886    79 LLLLSLLLLGLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQL 800
Cdd:COG4886   151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                         250       260
                  ....*....|....*....|....*
gi 2217268661 801 TQLELKGNCLDRLPaQLGQCRMLKK 825
Cdd:COG4886   231 ETLDLSNNQLTDLP-ELGNLTNLEE 254
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
547-856 2.81e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 133.52  E-value: 2.81e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 547 TDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNltkvpSNITDVApHLTKLVIHNdgTKLL 626
Cdd:COG4886    55 LLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLT-NLESLDLSG--NQLT 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 627 VL-NSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEiiSFQHLKRLTCLKLWHNKIVTIPPSITHV 705
Cdd:COG4886   127 DLpEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITDLPEPLGNL 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 706 KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPiEIGLLQNLQHLHITGNKVDILPKqLFKCIKLRTLNLGQN 785
Cdd:COG4886   205 TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNN 282

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217268661 786 CITSLpeKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALNQDINIPFAN 856
Cdd:COG4886   283 QLTDL--KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
488-808 3.96e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 115.03  E-value: 3.96e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 488 DLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTafsflrdHLRCLHVKFTDVAEIPAWVYLLKNLRELYL 567
Cdd:COG4886    71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLT-------NLESLDLSGNQLTDLPEELANLTNLKELDL 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 568 ignlnsENNKMIGL-ESLRELRHLKILHVKSNltkvpsNITDVAPHLTKLVihndgtkllvlnSLKkmmnvaELELQNCE 646
Cdd:COG4886   144 ------SNNQLTDLpEPLGNLTNLKSLDLSNN------QLTDLPEELGNLT------------NLK------ELDLSNNQ 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 647 LERIPHAIFSLSNLQELDLKSNNIRTIEEiiSFQHLKRLTCLKLWHNKIVTIPpSITHVKNLESLYFSNNKLESLPvAVF 726
Cdd:COG4886   194 ITDLPEPLGNLTNLEELDLSGNQLTDLPE--PLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLA 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 727 SLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELK 806
Cdd:COG4886   270 NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLAL 349


                  ..
gi 2217268661 807 GN 808
Cdd:COG4886   350 LT 351
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
405-805 3.64e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.07  E-value: 3.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 405 SFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLSGVPD 484
Cdd:COG4886    11 KLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 485 AVFDLTDLDVLKLELIPEakipakISQMTNLQELHLCHCPAKVEQTAFSFLRdHLRCLHVKFTDVAEIPAWVYLLKNLRE 564
Cdd:COG4886    91 DLGDLTNLTELDLSGNEE------LSNLTNLESLDLSGNQLTDLPEELANLT-NLKELDLSNNQLTDLPEPLGNLTNLKS 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 565 LYLignlnsENNKMIGL-ESLRELRHLKILHVKSN-LTKVPSNITDvAPHLTKLVIhnDGTKLLVL-NSLKKMMNVAELE 641
Cdd:COG4886   164 LDL------SNNQLTDLpEELGNLTNLKELDLSNNqITDLPEPLGN-LTNLEELDL--SGNQLTDLpEPLANLTNLETLD 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 642 LQNCELERIPhAIFSLSNLQELDLKSNNIRTIEEIisfQHLKRLTCLKLWHNKIVTIP-PSITHVKNLESLYFSNNKLES 720
Cdd:COG4886   235 LSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL---ANLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNL 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQL 800
Cdd:COG4886   311 LELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390


                  ....*
gi 2217268661 801 TQLEL 805
Cdd:COG4886   391 LLLLT 395
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 590-841 4.76e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 82.97  E-value: 4.76e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 590 LKILHVKSNLT--KVPSNITDvaphLTKLVIHNDGTKLLV---LNSLKKMMNVAELELQNCELE-RIPHAIFSLSNLQEL 663
Cdd:PLN00113  166 LKVLDLGGNVLvgKIPNSLTN----LTSLEFLTLASNQLVgqiPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHL 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 664 DLKSNNIrTIEEIISFQHLKRLTCLKLWHNKIV-TIPPSITHVKNLESLYFSNNKLE-SLPVAVFSLQKLRCLDVSYNNI 741
Cdd:PLN00113  242 DLVYNNL-TGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNF 320

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 742 S-MIPIEIGLLQNLQHLHITGNKVD-ILPKQLFKCIKLRTLNLGQNCITS-LPEKVGQLSQLTQLELKGNCLD-RLPAQL 817
Cdd:PLN00113  321 TgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEgEIPKSL 400

                         250       260
                  ....*....|....*....|....
gi 2217268661 818 GQCRMLKKSGLvVEDHLFDTLPLE 841
Cdd:PLN00113  401 GACRSLRRVRL-QDNSFSGELPSE 423
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 640-814 6.99e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.52  E-value: 6.99e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 640 LELQNCELERIPhAIFSLSNLQELDLKSNNIRTIEeiiSFQHLKRLTCLKLWHNKIVTIPPsITHVKNLESLYFSNNK-- 717
Cdd:cd21340     7 LYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRis 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 718 -LESLPvavfSLQKLRCLDVSYNNI-----------SMIpieiGLLQNLQHLHITGNKVDILpKQLFKCIKLRTLNLGQN 785
Cdd:cd21340    82 vVEGLE----NLTNLEELHIENQRLppgekltfdprSLA----ALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNN 152

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2217268661 786 CITSLPE---KVGQLSQLTQLELKGNCLDRLP 814
Cdd:cd21340   153 QISDLEElldLLSSWPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 636-791 1.43e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 76.75  E-value: 1.43e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 636 NVAELELQNCELERIPHaIFSLSNLQELDLKSNNIRTIEeiiSFQHLKRLTCLKLWHNKIVTIpPSITHVKNLESLYFSN 715
Cdd:cd21340    25 NLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIEN 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 716 NKL---ESL---PVAVFSLQK-LRCLDVSYNNISmIPIEIGLLQNLQHLHITGNKVDILPKQ---LFKCIKLRTLNLGQN 785
Cdd:cd21340   100 QRLppgEKLtfdPRSLAALSNsLRVLNISGNNID-SLEPLAPLRNLEQLDASNNQISDLEELldlLSSWPSLRELDLTGN 178


                  ....*.
gi 2217268661 786 CITSLP 791
Cdd:cd21340   179 PVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 449-839 1.00e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.19  E-value: 1.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 449 ISLNH-EWTFEKLRQHISRNAQDKQELH-LF----MLSG-VPDAVFDLTDLDVLKL-ELIPEAKIPAKISQMTNLQELHL 520
Cdd:PLN00113  236 TSLNHlDLVYNNLTGPIPSSLGNLKNLQyLFlyqnKLSGpIPPSIFSLQKLISLDLsDNSLSGEIPELVIQLQNLEILHL 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 521 chcpakveqtaFSflrdhlrclhVKFTdvAEIPAWVYLLKNLRELYLIGN-LNSENNKMIGLESlrelrHLKILHVKSN- 598
Cdd:PLN00113  316 -----------FS----------NNFT--GKIPVALTSLPRLQVLQLWSNkFSGEIPKNLGKHN-----NLTVLDLSTNn 367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 599 LT-KVPSNITDvAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELE-RIPHAIFSLSNLQELDLKSNNIrtieei 676
Cdd:PLN00113  368 LTgEIPEGLCS-SGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNL------ 440

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 677 isfqhLKRLTCLKlWHnkivtippsithVKNLESLYFSNNK-LESLPvAVFSLQKLRCLDVSYNNIS-MIPIEIGLLQNL 754
Cdd:PLN00113  441 -----QGRINSRK-WD------------MPSLQMLSLARNKfFGGLP-DSFGSKRLENLDLSRNQFSgAVPRKLGSLSEL 501

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 755 QHLHITGNKVD-ILPKQLFKCIKLRTLNLGQNCIT-SLPEKVGQLSQLTQLELKGNCLD-RLPAQLGQCRMLKKSGLvVE 831
Cdd:PLN00113  502 MQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNI-SH 580


                  ....*...
gi 2217268661 832 DHLFDTLP 839
Cdd:PLN00113  581 NHLHGSLP 588
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 504-823 1.68e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.42  E-value: 1.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 504 KIPAKISQMTNLQELHLC------HCPAKVEQ-TAFSFLRDHLRCLhvkftdVAEIPAWVYLLKNLRELYL-IGNLNSEN 575
Cdd:PLN00113  155 EIPNDIGSFSSLKVLDLGgnvlvgKIPNSLTNlTSLEFLTLASNQL------VGQIPRELGQMKSLKWIYLgYNNLSGEI 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 576 NKMIGleSLRELRHLKIlhVKSNLT-KVPSNITDVApHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELE-RIPHA 653
Cdd:PLN00113  229 PYEIG--GLTSLNHLDL--VYNNLTgPIPSSLGNLK-NLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPEL 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 654 IFSLSNLQELDLKSNNIR-TIEEIISfqHLKRLTCLKLWHNKIV------------------------------------ 696
Cdd:PLN00113  304 VIQLQNLEILHLFSNNFTgKIPVALT--SLPRLQVLQLWSNKFSgeipknlgkhnnltvldlstnnltgeipeglcssgn 381

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 697 -------------TIPPSITHVKNLESLYFSNNKLE-SLPVAVFSLQKLRCLDVSYNNIS-MIPIEIGLLQNLQHLHITG 761
Cdd:PLN00113  382 lfklilfsnslegEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLAR 461

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217268661 762 NKVDILPKQLFKCIKLRTLNLGQNCIT-SLPEKVGQLSQLTQLELKGNCLD-RLPAQLGQCRML 823
Cdd:PLN00113  462 NKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKL 525
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
586-817 2.52e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 70.88  E-value: 2.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 586 ELRhLKILhvksNLTKVPSNITDvapHLTKLVIHNDGTKLLVLNSlkkMMNVAELELQNCELERIPHAIfsLSNLQELDL 665
Cdd:PRK15370  182 ELR-LKIL----GLTTIPACIPE---QITTLILDNNELKSLPENL---QGNIKTLYANSNQLTSIPATL--PDTIQEMEL 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 666 KSNNIRTIEEiisfqHL-KRLTCLKLWHNKIVTIPpsithvknleslyfsnnklESLPvavfslQKLRCLDVSYNNISMI 744
Cdd:PRK15370  249 SINRITELPE-----RLpSALQSLDLFHNKISCLP-------------------ENLP------EELRYLSVYDNSIRTL 298

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217268661 745 PIEigLLQNLQHLHITGNKVDILPKQLfkCIKLRTLNLGQNCITSLPEKVGqlSQLTQLELKGNCLDRLPAQL 817
Cdd:PRK15370  299 PAH--LPSGITHLNVQSNSLTALPETL--PPGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETL 365
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 682-825 8.86e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 8.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 682 LKRLTCLKLWHNKIVTIP---------------------PSITHVKNLESLYFSNNKLESLPVaVFSLQKLRCLDVSYNN 740
Cdd:cd21340     1 LKRITHLYLNDKNITKIDnlslcknlkvlylydnkitkiENLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 741 ISMIpieIGL--LQNLQHLHI------TGNKVDILPKQLF---KCikLRTLNLGQNCITSLpEKVGQLSQLTQLELKGNC 809
Cdd:cd21340    80 ISVV---EGLenLTNLEELHIenqrlpPGEKLTFDPRSLAalsNS--LRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQ 153

                         170
                  ....*....|....*....
gi 2217268661 810 LDRLPAQ---LGQCRMLKK 825
Cdd:cd21340   154 ISDLEELldlLSSWPSLRE 172
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 640-808 2.47e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 57.11  E-value: 2.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 640 LELQNCELERIPHAIFSLSNLQELDLKSNNI--RTIEEIIS-FQHLKRLTCLKLWHNKI-----VTIPPSITHVKNLESL 711
Cdd:COG5238   190 NQIGDEGIEELAEALTQNTTVTTLWLKRNPIgdEGAEILAEaLKGNKSLTTLDLSNNQIgdegvIALAEALKNNTTVETL 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 712 YFSNNKL-----ESLPVAVFSLQKLRCLDVSYNNISMiPIEIGLLQNLQHLHItgnkvdilpkqlfkcikLRTLNLGQNC 786
Cdd:COG5238   270 YLSGNQIgaegaIALAKALQGNTTLTSLDLSVNRIGD-EGAIALAEGLQGNKT-----------------LHTLNLAYNG 331

                         170       180
                  ....*....|....*....|....*..
gi 2217268661 787 IT-----SLPEKVGQLSQLTQLELKGN 808
Cdd:COG5238   332 IGaqgaiALAKALQENTTLHSLDLSDN 358
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 540-716 1.32e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.25  E-value: 1.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 540 RCLHVKFTD--VAEIPAwVYLLKNLRELYL-------IGNLNS---------ENNKMIGLESLRELRHLKILHVKSNltk 601
Cdd:cd21340     3 RITHLYLNDknITKIDN-LSLCKNLKVLYLydnkitkIENLEFltnlthlylQNNQIEKIENLENLVNLKKLYLGGN--- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 602 vpsNITdvaphltklvihndgtkllVLNSLKKMMNVAELELQN------CELERIPHAIFSLSN-LQELDLKSNNIRTIE 674
Cdd:cd21340    79 ---RIS-------------------VVEGLENLTNLEELHIENqrlppgEKLTFDPRSLAALSNsLRVLNISGNNIDSLE 136

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2217268661 675 EiisFQHLKRLTCLKLWHNKIVTIP---PSITHVKNLESLYFSNN 716
Cdd:cd21340   137 P---LAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
636-695 1.56e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.56e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217268661 636 NVAELELQNCELERI-PHAIFSLSNLQELDLKSNNIRTIEEiISFQHLKRLTCLKLWHNKI 695
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
658-718 2.37e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 2.37e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217268661 658 SNLQELDLKSNNIRTIEEIiSFQHLKRLTCLKLWHNKIVTIPP-SITHVKNLESLYFSNNKL 718
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDG-AFKGLSNLKVLDLSNNLLTTLSPgAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
684-741 9.93e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 9.93e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 684 RLTCLKLWHNKIVTIPPSI-THVKNLESLYFSNNKLESLPVAVFS-LQKLRCLDVSYNNI 741
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
660-816 1.13e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 52.47  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 660 LQELDLKSNNIRTIEEIISfqhlkrlTCLKLW--HNKIVTIPpsiTHVKNLESLYFSNNKLESLPVAVFSLQKL------ 731
Cdd:PRK15387  304 LQELSVSDNQLASLPALPS-------ELCKLWayNNQLTSLP---TLPSGLQELSVSDNQLASLPTLPSELYKLwaynnr 373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 732 -----------RCLDVSYNNISMIPIeigLLQNLQHLHITGNKVDILPkqlFKCIKLRTLNLGQNCITSLPEKVGQLSQL 800
Cdd:PRK15387  374 ltslpalpsglKELIVSGNRLTSLPV---LPSELKELMVSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPESLIHLSSE 447

                         170
                  ....*....|....*.
gi 2217268661 801 TQLELKGNCLDRLPAQ 816
Cdd:PRK15387  448 TTVNLEGNPLSERTLQ 463
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 649-829 2.49e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.39  E-value: 2.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 649 RIPHAIFSLSNLQELDLKSNNIrtieeiiSFQhlkrltclklwhnkivtIPPSI-THVKNLESLYFSNNKLeSLPVAVFS 727
Cdd:PLN00113   84 KISSAIFRLPYIQTINLSNNQL-------SGP-----------------IPDDIfTTSSSLRYLNLSNNNF-TGSIPRGS 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 728 LQKLRCLDVSYNNIS-MIPIEIGLLQNLQHLHITGNK-VDILPKQLFKCIKLRTLNLGQNCIT-SLPEKVGQLSQLTQLE 804
Cdd:PLN00113  139 IPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVlVGKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIY 218

                         170       180
                  ....*....|....*....|....*.
gi 2217268661 805 LKGNCLD-RLPAQLGQCRMLKKSGLV 829
Cdd:PLN00113  219 LGYNNLSgEIPYEIGGLTSLNHLDLV 244
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 559-711 5.55e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 5.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 559 LKNLRELYLIGNLNSennKMIGLESLRELRHLKILHVKS----NLTKVPSNITDVAPHLTKLVIHNDgtkllvlnslkKM 634
Cdd:cd21340    67 LVNLKKLYLGGNRIS---VVEGLENLTNLEELHIENQRLppgeKLTFDPRSLAALSNSLRVLNISGN-----------NI 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 635 MNVAELElqnceleriphaifSLSNLQELDLKSNNIRTIEEII-SFQHLKRLTCLKLWHNKIVTIP----PSITHVKNLE 709
Cdd:cd21340   133 DSLEPLA--------------PLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVCKKPkyrdKIILASKSLE 198


                  ..
gi 2217268661 710 SL 711
Cdd:cd21340   199 VL 200
LRR_8 pfam13855
Leucine rich repeat;
752-808 6.86e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 6.86e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217268661 752 QNLQHLHITGNKVDILPKQLFK-CIKLRTLNLGQNCITSLPEKVGQ-LSQLTQLELKGN 808
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
707-764 1.11e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 1.11e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 707 NLESLYFSNNKLESLPVAVFS-LQKLRCLDVSYNNISMI-PIEIGLLQNLQHLHITGNKV 764
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
628-827 1.19e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 49.01  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 628 LNSLKKMMNVAE---LELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEeiISFQHLKRLTCLKLWHNKIVTIPPSITH 704
Cdd:PRK15387  199 LNNGNAVLNVGEsglTTLPDCLPAHITTLVIPDNNLTSLPALPPELRTLE--VSGNQLTSLPVLPPGLLELSIFSNPLTH 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 705 VKNLES----LYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEI--------------GLLQNLQHLHITGNKVDI 766
Cdd:PRK15387  277 LPALPSglckLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPALPSELcklwaynnqltslpTLPSGLQELSVSDNQLAS 356

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217268661 767 LPKQLFKCIKLRTLNlgqNCITSLPekvGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSG 827
Cdd:PRK15387  357 LPTLPSELYKLWAYN---NRLTSLP---ALPSGLKELIVSGNRLTSLPVLPSELKELMVSG 411
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 484-715 2.48e-05

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 48.33  E-value: 2.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661  484 DAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAE-IPAWVYL---- 558
Cdd:PLN03210   628 DGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSRCENLEiLPTGINLksly 707

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661  559 ---------LK-------NLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSN--ITDVAPHLTKLVIHN 620
Cdd:PLN03210   708 rlnlsgcsrLKsfpdistNISWLDLDETAIEEFPSNLRLENLDELILCEMKSEKLWERVQPLTplMTMLSPSLTRLFLSD 787

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661  621 DGTKLLVLNSLKKMMNVAELELQNC-ELERIPHAIfSLSNLQELDLK-----------SNNI------RT-IEE----II 677
Cdd:PLN03210   788 IPSLVELPSSIQNLHKLEHLEIENCiNLETLPTGI-NLESLESLDLSgcsrlrtfpdiSTNIsdlnlsRTgIEEvpwwIE 866

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 2217268661  678 SFQHLKRLTCLKLwhNKIVTIPPSITHVKNLESLYFSN 715
Cdd:PLN03210   867 KFSNLSFLDMNGC--NNLQRVSLNISKLKHLETVDFSD 902
PLN03150 PLN03150
hypothetical protein; Provisional
 698-762 3.05e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.50  E-value: 3.05e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217268661 698 IPPSITHVKNLESLYFSNNKLE-SLPVAVFSLQKLRCLDVSYNNIS-MIPIEIGLLQNLQHLHITGN 762
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGN 500
PLN03150 PLN03150
hypothetical protein; Provisional
 744-818 3.21e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.50  E-value: 3.21e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217268661 744 IPIEIGLLQNLQHLHITGNKVD-ILPKQLFKCIKLRTLNLGQNCIT-SLPEKVGQLSQLTQLELKGNCLD-RLPAQLG 818
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 636-771 1.18e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 46.02  E-value: 1.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661  636 NVAELELQNCELERIPHAIFSLSNLQELDL-KSNNIRTIEEIISFQHLKRL---TCLKLwhnkiVTIPPSITHVKNLESL 711
Cdd:PLN03210   612 NLVKLQMQGSKLEKLWDGVHSLTGLRNIDLrGSKNLKEIPDLSMATNLETLklsDCSSL-----VELPSSIQYLNKLEDL 686

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217268661  712 YFSN-NKLESLPVAVfSLQKLRCLDVsyNNISMIPIEIGLLQNLQHLHITGNKVDILPKQL 771
Cdd:PLN03210   687 DMSRcENLEILPTGI-NLKSLYRLNL--SGCSRLKSFPDISTNISWLDLDETAIEEFPSNL 744
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 582-816 1.42e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 582 ESLRELRHLKILHVKSNLTKVpSNITDVAPHLTklviHNDGTKLLVLnslkKMMNVAELELQnceLERIPHAIFSLSNLQ 661
Cdd:cd00116    17 ELLPKLLCLQVLRLEGNTLGE-EAAKALASALR----PQPSLKELCL----SLNETGRIPRG---LQSLLQGLTKGCGLQ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 662 ELDLkSNN---IRTIEEIISFQHLKRLTCLKLWHNKI-----VTIPPSITHVK-NLESLYFSNNKL-----ESLPVAVFS 727
Cdd:cd00116    85 ELDL-SDNalgPDGCGVLESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPpALEKLVLGRNRLegascEALAKALRA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 728 LQKLRCLDVSYNNISMIPIEI---GL--LQNLQHLHITGNKV-DILPKQLFKCIK----LRTLNLGQNCITS------LP 791
Cdd:cd00116   164 NRDLKELNLANNGIGDAGIRAlaeGLkaNCNLEVLDLNNNGLtDEGASALAETLAslksLEVLNLGDNNLTDagaaalAS 243

                         250       260
                  ....*....|....*....|....*
gi 2217268661 792 EKVGQLSQLTQLELKGNCLDRLPAQ 816
Cdd:cd00116   244 ALLSPNISLLTLSLSCNDITDDGAK 268
LRR_9 pfam14580
Leucine-rich repeat;
639-745 1.80e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 43.21  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 639 ELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEeiiSFQHLKRLTCLKLWHNKIVTIPPSITHV-KNLESLYFSNNK 717
Cdd:pfam14580  23 ELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLD---GFPLLRRLKTLLLNNNRICRIGEGLGEAlPNLTELILTNNN 99

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2217268661 718 LESL----PVAvfSLQKLRCLDVSYNNISMIP 745
Cdd:pfam14580 100 LQELgdldPLA--SLKKLTFLSLLRNPVTNKP 129
LRR_8 pfam13855
Leucine rich repeat;
729-785 1.22e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.22e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217268661 729 QKLRCLDVSYNNISMIPIEIGL-LQNLQHLHITGNKVDILPKQLFKCI-KLRTLNLGQN 785
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSGLpSLRYLDLSGN 59
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 706-740 3.63e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 3.63e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2217268661 706 KNLESLYFSNNKLESLPVAVfSLQKLRCLDVSYNN 740
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLA-KLPNLETLDLSGNN 34
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 509-695 5.06e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 5.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 509 ISQMTNLQELHLCHCPakVEQTAFSFLRDHLRclhvkftDVAEipawvyllkNLRELYLIGNlNSENNKMIGL-ESLREL 587
Cdd:cd00116   104 LLRSSSLQELKLNNNG--LGDRGLRLLAKGLK-------DLPP---------ALEKLVLGRN-RLEGASCEALaKALRAN 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268661 588 RHLKILHVKSNltkvpsNITDVA-PHLTKLVIHNDGTKLLVLNSLKkmmnvaeLELQNCELerIPHAIFSLSNLQELDLK 666
Cdd:cd00116   165 RDLKELNLANN------GIGDAGiRALAEGLKANCNLEVLDLNNNG-------LTDEGASA--LAETLASLKSLEVLNLG 229

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2217268661 667 SNNIRT--IEEIISfQHLKRLTCLK---LWHNKI 695
Cdd:cd00116   230 DNNLTDagAAALAS-ALLSPNISLLtlsLSCNDI 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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