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Conserved domains on  [gi|2217279355|ref|XP_047281948|]
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ankyrin repeat domain-containing protein 30A isoform X4 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 13839442)

ankyrin (ANK) repeat domain-containing protein may be involved in mediating protein-protein interactions; similar to Mus musculus POTE ankyrin domain family member A isoform 2

Gene Ontology:  GO:0005515
PubMed:  17176038

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
42-272 4.44e-42

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 155.88  E-value: 4.44e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   42 IHKAASRGQVRKLEKMTKRKKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEAC 121
Cdd:COG0666     56 LLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEI 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  122 ANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAV 201
Cdd:COG0666    136 VKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217279355  202 NKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCGFHHIHEQIMEYIRKLSKNHQNTN 272
Cdd:COG0666    216 DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLL 286
PTZ00121 super family cl31754
MAEBL; Provisional
 536-1038 1.04e-03

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 1.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  536 KAFELKNEQTLRADEilPSESKQKDYEENSWDTESLCETVSQKDVCLPKAAHQKEIDKINGKLEGRYAAEFRtfsamirs 615
Cdd:PTZ00121  1077 KDFDFDAKEDNRADE--ATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEAR-------- 1146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  616 pvkdgllKANCGMKVSIPTKALELMDMQ-TFKAEPPEKPSAFEPAIEMQKsvpnkALEL-KNEQTLRADEILPSESKQKD 693
Cdd:PTZ00121  1147 -------KAEDAKRVEIARKAEDARKAEeARKAEDAKKAEAARKAEEVRK-----AEELrKAEDARKAEAARKAEEERKA 1214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  694 YEESSWDSESLCETVSQKDVCLPKAAHQKEIDKINGKLEGSPVKDGLLKANCGMKVSIptkalelmdmqtfKAEPPEKPS 773
Cdd:PTZ00121  1215 EEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAI-------------KAEEARKAD 1281

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  774 AFEPAIEMQKSVPNKalelKNEQTLRADEILPSESKQKDYEESSWDSEslcETVSQKDVCLPKATHQKEIDKINGKLEES 853
Cdd:PTZ00121  1282 ELKKAEEKKKADEAK----KAEEKKKADEAKKKAEEAKKADEAKKKAE---EAKKKADAAKKKAEEAKKAAEAAKAEAEA 1354

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  854 PDNDgfLKAPCRMKvsiptKALELMdmqtfKAEPPEKPSAFEPAIEMQKsvpnKALELKN---EQTLRADQMFPSESKQK 930
Cdd:PTZ00121  1355 AADE--AEAAEEKA-----EAAEKK-----KEEAKKKADAAKKKAEEKK----KADEAKKkaeEDKKKADELKKAAAAKK 1418

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  931 KVEENSWDSESLRETVSQKDvcvpKATHQKEMDKISGKLEDSTSLSKILDTVHSCERARELQKDHCEQRTG-----KMEQ 1005
Cdd:PTZ00121  1419 KADEAKKKAEEKKKADEAKK----KAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKAdeakkKAEE 1494

                          490       500       510
                   ....*....|....*....|....*....|...
gi 2217279355 1006 MKKKFCVLKKKLSEAKEIKSQLENQKVKWEQEL 1038
Cdd:PTZ00121  1495 AKKKADEAKKAAEAKKKADEAKKAEEAKKADEA 1527
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
42-272 4.44e-42

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 155.88  E-value: 4.44e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   42 IHKAASRGQVRKLEKMTKRKKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEAC 121
Cdd:COG0666     56 LLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEI 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  122 ANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAV 201
Cdd:COG0666    136 VKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217279355  202 NKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCGFHHIHEQIMEYIRKLSKNHQNTN 272
Cdd:COG0666    216 DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLL 286
Ank_2 pfam12796
Ankyrin repeats (3 copies);
77-169 3.08e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 80.55  E-value: 3.08e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   77 LHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANILIDSgADINLVDvYGNTALHYAVYSEILSVVA 156
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 2217279355  157 KLLSHGAVIEVHN 169
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 65-213 1.58e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 83.78  E-value: 1.58e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   65 NLNIQDAQK-RTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANILIDSGADINLVDVYGNTAL 143
Cdd:PHA02878   159 DINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPL 238

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217279355  144 HYAVYSEI-LSVVAKLLSHGAviEVHNKAS---LTPLLLSItkRSEQIVEFLLIKNANANAVNKYKCTALMLAV 213
Cdd:PHA02878   239 HISVGYCKdYDILKLLLEHGV--DVNAKSYilgLTALHSSI--KSERKLKLLLEYGADINSLNSYKLTPLSSAV 308
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 72-194 2.98e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 2.98e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   72 QKRTALHWACVNGHEEVV-----------------TFLVDRKCQLdVLDGEHrtPLMKALQCHQEACANILIDSGADINL 134
Cdd:cd22192     88 QGETALHIAVVNQNLNLVreliargadvvspratgTFFRPGPKNL-IYYGEH--PLSFAACVGNEEIVRLLIEHGADIRA 164

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217279355  135 VDVYGNTALHYAV-----------YSEILSVVAKLLSHgAVIEVHNKASLTPLLLSITKRSEQIVEFLLIK 194
Cdd:cd22192    165 QDSLGNTVLHILVlqpnktfacqmYDLILSYDKEDDLQ-PLDLVPNNQGLTPFKLAAKEGNIVMFQHLVQK 234
PTZ00121 PTZ00121
MAEBL; Provisional
 536-1038 1.04e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 1.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  536 KAFELKNEQTLRADEilPSESKQKDYEENSWDTESLCETVSQKDVCLPKAAHQKEIDKINGKLEGRYAAEFRtfsamirs 615
Cdd:PTZ00121  1077 KDFDFDAKEDNRADE--ATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEAR-------- 1146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  616 pvkdgllKANCGMKVSIPTKALELMDMQ-TFKAEPPEKPSAFEPAIEMQKsvpnkALEL-KNEQTLRADEILPSESKQKD 693
Cdd:PTZ00121  1147 -------KAEDAKRVEIARKAEDARKAEeARKAEDAKKAEAARKAEEVRK-----AEELrKAEDARKAEAARKAEEERKA 1214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  694 YEESSWDSESLCETVSQKDVCLPKAAHQKEIDKINGKLEGSPVKDGLLKANCGMKVSIptkalelmdmqtfKAEPPEKPS 773
Cdd:PTZ00121  1215 EEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAI-------------KAEEARKAD 1281

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  774 AFEPAIEMQKSVPNKalelKNEQTLRADEILPSESKQKDYEESSWDSEslcETVSQKDVCLPKATHQKEIDKINGKLEES 853
Cdd:PTZ00121  1282 ELKKAEEKKKADEAK----KAEEKKKADEAKKKAEEAKKADEAKKKAE---EAKKKADAAKKKAEEAKKAAEAAKAEAEA 1354

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  854 PDNDgfLKAPCRMKvsiptKALELMdmqtfKAEPPEKPSAFEPAIEMQKsvpnKALELKN---EQTLRADQMFPSESKQK 930
Cdd:PTZ00121  1355 AADE--AEAAEEKA-----EAAEKK-----KEEAKKKADAAKKKAEEKK----KADEAKKkaeEDKKKADELKKAAAAKK 1418

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  931 KVEENSWDSESLRETVSQKDvcvpKATHQKEMDKISGKLEDSTSLSKILDTVHSCERARELQKDHCEQRTG-----KMEQ 1005
Cdd:PTZ00121  1419 KADEAKKKAEEKKKADEAKK----KAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKAdeakkKAEE 1494

                          490       500       510
                   ....*....|....*....|....*....|...
gi 2217279355 1006 MKKKFCVLKKKLSEAKEIKSQLENQKVKWEQEL 1038
Cdd:PTZ00121  1495 AKKKADEAKKAAEAKKKADEAKKAEEAKKADEA 1527
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 72-101 1.08e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 1.08e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 2217279355    72 QKRTALHWACVNGHEEVVTFLVDRKCQLDV 101
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
42-272 4.44e-42

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 155.88  E-value: 4.44e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   42 IHKAASRGQVRKLEKMTKRKKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEAC 121
Cdd:COG0666     56 LLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEI 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  122 ANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAV 201
Cdd:COG0666    136 VKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217279355  202 NKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCGFHHIHEQIMEYIRKLSKNHQNTN 272
Cdd:COG0666    216 DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLL 286
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-272 3.63e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 153.19  E-value: 3.63e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   29 NDSYIVHSGDLRKIHKAASRGQVRKLEKMTKRKKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRT 108
Cdd:COG0666     10 LLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNT 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  109 PLMKALQCHQEACANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIV 188
Cdd:COG0666     90 LLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIV 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  189 EFLLIKNANANAVNKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCGFHHIHEQIMEYIRKLSKNH 268
Cdd:COG0666    170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKD 249


                   ....
gi 2217279355  269 QNTN 272
Cdd:COG0666    250 KDGL 253
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
61-333 5.45e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.83  E-value: 5.45e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   61 KKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANILIDSGADINLVDVYGN 140
Cdd:COG0666      9 LLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGN 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  141 TALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAVNKYKCTALMLAVCHGSSEI 220
Cdd:COG0666     89 TLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEI 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  221 VGMLLQQNVDVFAADICGVTAEHYAVTCGfhhiHEQIMEYIRKLSKNHQNTNPEGTSAgtPDEAAplAERTPDTAESLVE 300
Cdd:COG0666    169 VKLLLEAGADVNARDNDGETPLHLAAENG----HLEIVKLLLEAGADVNAKDNDGKTA--LDLAA--ENGNLEIVKLLLE 240

                          250       260       270
                   ....*....|....*....|....*....|...
gi 2217279355  301 KTPDEAAPLVERTPDTAESLVEKTPDEAASLVE 333
Cdd:COG0666    241 AGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
42-209 6.29e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.83  E-value: 6.29e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   42 IHKAASRGQVRKLEKMTKRKktINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEAC 121
Cdd:COG0666    124 LHLAAYNGNLEIVKLLLEAG--ADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEI 201

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  122 ANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAV 201
Cdd:COG0666    202 VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAA 281


                   ....*...
gi 2217279355  202 NKYKCTAL 209
Cdd:COG0666    282 LLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
77-169 3.08e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 80.55  E-value: 3.08e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   77 LHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANILIDSgADINLVDvYGNTALHYAVYSEILSVVA 156
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 2217279355  157 KLLSHGAVIEVHN 169
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
42-136 2.52e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 2.52e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   42 IHKAASRGQVRKLEKMTKRKktINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGehRTPLMKALQCHQEAC 121
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENG--ADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNG--RTALHYAARSGHLEI 76

                           90
                   ....*....|....*
gi 2217279355  122 ANILIDSGADINLVD 136
Cdd:pfam12796   77 VKLLLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 65-213 1.58e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 83.78  E-value: 1.58e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   65 NLNIQDAQK-RTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANILIDSGADINLVDVYGNTAL 143
Cdd:PHA02878   159 DINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPL 238

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217279355  144 HYAVYSEI-LSVVAKLLSHGAviEVHNKAS---LTPLLLSItkRSEQIVEFLLIKNANANAVNKYKCTALMLAV 213
Cdd:PHA02878   239 HISVGYCKdYDILKLLLEHGV--DVNAKSYilgLTALHSSI--KSERKLKLLLEYGADINSLNSYKLTPLSSAV 308
PHA03095 PHA03095
ankyrin-like protein; Provisional
 103-292 4.88e-16

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 81.99  E-value: 4.88e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  103 DGEH-RTPLMKALQCHQEACANI---LIDSGADINLVDVYGNTALH-YAVYSEILSVVAKLLSHGAVIEVHNKASLTPL- 176
Cdd:PHA03095    43 RGEYgKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLh 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  177 -LLSITKRSEQIVEFLLIKNANANAVNKYKCTAL-MLAVCHGSS-EIVGMLLQQNVDVFAADICGVTAehyavtcgFHHI 253
Cdd:PHA03095   123 vYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLaVLLKSRNANvELLRLLIDAGADVYAVDDRFRSL--------LHHH 194

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2217279355  254 HEQIMEYIRKLSKNhqntnpegTSAGTPDEAAPLAERTP 292
Cdd:PHA03095   195 LQSFKPRARIVREL--------IRAGCDPAATDMLGNTP 225
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 92-246 1.05e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 80.86  E-value: 1.05e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   92 LVDRKCQLDVLDGEHRTPLMKALQCHQEACANILIDSGADINLVDVYGNTALHY-----AVYSEILSVVAKLLSHGAVIE 166
Cdd:PHA03100    21 IIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYlsnikYNLTDVKEIVKLLLEYGANVN 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  167 VHNKASLTPLLLSITKRSEQ--IVEFLLIKNANANAVNKYKCTALMLAV--CHGSSEIVGMLLQQNVDVFA--------- 233
Cdd:PHA03100   101 APDNNGITPLLYAISKKSNSysIVEYLLDNGANVNIKNSDGENLLHLYLesNKIDLKILKLLIDKGVDINAknrvnylls 180

                          170       180
                   ....*....|....*....|
gi 2217279355  234 -------ADICGVTAEHYAV 246
Cdd:PHA03100   181 ygvpiniKDVYGFTPLHYAV 200
Ank_2 pfam12796
Ankyrin repeats (3 copies);
143-235 4.61e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 4.61e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  143 LHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEfLLIKNANANAVNkYKCTALMLAVCHGSSEIVG 222
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVK-LLLEHADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 2217279355  223 MLLQQNVDVFAAD 235
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 61-241 2.61e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 73.52  E-value: 2.61e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   61 KKTINLNIQDAQKRTALHwACVNG---HEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHqEACA---NILIDSGADINL 134
Cdd:PHA03095   105 KAGADVNAKDKVGRTPLH-VYLSGfniNPKVIRLLLRKGADVNALDLYGMTPLAVLLKSR-NANVellRLLIDAGADVYA 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  135 VDVYGNTALHY-AVYSEI-LSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQ--IVEFLLIKNANANAVNKYKCTALM 210
Cdd:PHA03095   183 VDDRFRSLLHHhLQSFKPrARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKrsLVLPLLIAGISINARNRYGQTPLH 262

                          170       180       190
                   ....*....|....*....|....*....|.
gi 2217279355  211 LAVCHGSSEIVGMLLQQNVDVFAADICGVTA 241
Cdd:PHA03095   263 YAAVFNNPRACRRLIALGADINAVSSDGNTP 293
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 64-235 6.53e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 71.92  E-value: 6.53e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   64 INLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANILIDSGADINLVDVYGNTAL 143
Cdd:PHA02874   115 IDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPL 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  144 HYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITkRSEQIVEfLLIKNANANAVNKYKCTALMLAV---ChgSSEI 220
Cdd:PHA02874   195 HNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII-HNRSAIE-LLINNASINDQDIDGSTPLHHAInppC--DIDI 270

                          170
                   ....*....|....*
gi 2217279355  221 VGMLLQQNVDVFAAD 235
Cdd:PHA02874   271 IDILLYHKADISIKD 285
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 64-204 6.75e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 72.01  E-value: 6.75e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   64 INLNIQDAQKRTALHWACVNGHE--EVVTFLVDRKCQLDVLDGehrtplmkalqchqeacANILIDSGADINLVDVYGNT 141
Cdd:PHA03100   132 ANVNIKNSDGENLLHLYLESNKIdlKILKLLIDKGVDINAKNR-----------------VNYLLSYGVPINIKDVYGFT 194

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217279355  142 ALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAVNKY 204
Cdd:PHA03100   195 PLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIET 257
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 86-246 3.78e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 69.69  E-value: 3.78e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   86 EEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACAN-----ILIDSGADINLVDVYGNTALHYAVYSEI--LSVVAKL 158
Cdd:PHA03100    48 IDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTDVkeivkLLLEYGANVNAPDNNGITPLLYAISKKSnsYSIVEYL 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  159 LSHGAVIEVHNKASLTPL--LLSITKRSEQIVEFLLIKNANANAVNKYKC----------------TALMLAVCHGSSEI 220
Cdd:PHA03100   128 LDNGANVNIKNSDGENLLhlYLESNKIDLKILKLLIDKGVDINAKNRVNYllsygvpinikdvygfTPLHYAVYNNNPEF 207

                          170       180
                   ....*....|....*....|....*.
gi 2217279355  221 VGMLLQQNVDVFAADICGVTAEHYAV 246
Cdd:PHA03100   208 VKYLLDLGANPNLVNKYGDTPLHIAI 233
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 61-245 6.82e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 69.71  E-value: 6.82e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   61 KKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDV--LDG--------------------EHRT-------PLM 111
Cdd:PHA02876   166 EGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIiaLDDlsvlecavdsknidtikaiiDNRSninkndlSLL 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  112 KALQCHQEACANILIDSGADINLVDVYGNTALHYAVYSEILS-VVAKLLSHGAVIEVHNKASLTPL-LLSITKRSEQIVE 189
Cdd:PHA02876   246 KAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLyLMAKNGYDTENIR 325

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217279355  190 FLLIKNANANAVNKYKCTALMLA-VCHGSSEIVGMLLQQNVDVFAADICGVTAEHYA 245
Cdd:PHA02876   326 TLIMLGADVNAADRLYITPLHQAsTLDRNKDIVITLLELGANVNARDYCDKTPIHYA 382
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 61-231 2.89e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 67.00  E-value: 2.89e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   61 KKTINLNIQDAQKRTALHWACVNGHE-----EVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANI--LIDSGADIN 133
Cdd:PHA03100    56 DNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSIVeyLLDNGANVN 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  134 LVDVYGNTALHYAVYS-----EILSV-------------VAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKN 195
Cdd:PHA03100   136 IKNSDGENLLHLYLESnkidlKILKLlidkgvdinaknrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLG 215

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 2217279355  196 ANANAVNKYKCTALMLAVCHGSSEIVGMLLQQNVDV 231
Cdd:PHA03100   216 ANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSI 251
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 74-230 2.36e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 63.86  E-value: 2.36e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   74 RTALHWACVNGHEEVVTFLVD-RKCQLDVLDGEHRTPLMKALQCHQEACANILIDSGADINLVDVYGNTALHYAVYSEIL 152
Cdd:PHA02875    69 ESELHDAVEEGDVKAVEELLDlGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217279355  153 SVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAVNKYKCTALM-LAVCHGSSEIVGMLLQQNVD 230
Cdd:PHA02875   149 KGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALcYAIENNKIDIVRLFIKRGAD 227
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 22-260 2.62e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 64.31  E-value: 2.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   22 SQLVYTSNDSyiVHSGDLRK---IHKAASRGQVRKL-EKMTKRKktINLNIQDAQKRTALHWACVNGHE-EVVTFLVDRK 96
Cdd:PHA02876   256 SLLLYDAGFS--VNSIDDCKntpLHHASQAPSLSRLvPKLLERG--ADVNAKNIKGETPLYLMAKNGYDtENIRTLIMLG 331

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   97 CQLDVLDGEHRTPLMKALQCHQEACANI-LIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTP 175
Cdd:PHA02876   332 ADVNAADRLYITPLHQASTLDRNKDIVItLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTA 411

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  176 LLLSITKRSEQI-VEFLLIKNANANAVNKYKCTALMLAvCHGSS--EIVGMLLQQNVDVFAADIcgvtAEHYA--VTCGF 250
Cdd:PHA02876   412 LHFALCGTNPYMsVKTLIDRGANVNSKNKDLSTPLHYA-CKKNCklDVIEMLLDNGADVNAINI----QNQYPllIALEY 486

                          250
                   ....*....|
gi 2217279355  251 HHIHEQIMEY 260
Cdd:PHA02876   487 HGIVNILLHY 496
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
122-260 4.34e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.89  E-value: 4.34e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  122 ANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAV 201
Cdd:COG0666      4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217279355  202 NKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCGfhhiHEQIMEY 260
Cdd:COG0666     84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG----NLEIVKL 138
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 49-246 1.85e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 61.13  E-value: 1.85e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   49 GQVRKLEKMTKRKKTInLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQ------------- 115
Cdd:PHA02874    12 GDIEAIEKIIKNKGNC-INISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKigahdiikllidn 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  116 ----------CHQEACANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSE 185
Cdd:PHA02874    91 gvdtsilpipCIEKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFF 170

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217279355  186 QIVEFLLIKNANANAVNKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAV 246
Cdd:PHA02874   171 DIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAI 231
Ank_2 pfam12796
Ankyrin repeats (3 copies);
176-261 3.11e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.74  E-value: 3.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  176 LLLSITKRSEQIVEFLLIKNANANAVNKYKCTALMLAVCHGSSEIVgMLLQQNVDVFAADIcGVTAEHYAVTCGfhhiHE 255
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIV-KLLLEHADVNLKDN-GRTALHYAARSG----HL 74


                   ....*.
gi 2217279355  256 QIMEYI 261
Cdd:pfam12796   75 EIVKLL 80
PHA03095 PHA03095
ankyrin-like protein; Provisional
 70-201 3.99e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 60.42  E-value: 3.99e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   70 DAQKRTALHWACVNGH--EEVVTFLVDRKCQLDVLDGEHRTPL-MKALQChqeACANI----LIDSGADINLVDVYGNTA 142
Cdd:PHA03095   184 DDRFRSLLHHHLQSFKprARIVRELIRAGCDPAATDMLGNTPLhSMATGS---SCKRSlvlpLLIAGISINARNRYGQTP 260

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217279355  143 LHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAV 201
Cdd:PHA03095   261 LHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETV 319
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 88-314 1.20e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 59.31  E-value: 1.20e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   88 VVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIev 167
Cdd:PHA02876   160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNI-- 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  168 hNKASLTpLLLSItkRSEQIVEFLLIKNA--NANAVNKYKCTALMLAVCHGS-SEIVGMLLQQNVDVFAADICGVTAEHY 244
Cdd:PHA02876   238 -NKNDLS-LLKAI--RNEDLETSLLLYDAgfSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPLYL 313

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217279355  245 AVTCGFHhiheqiMEYIRKLSKNHQNTNPEGTSAGTPDEAAPLAERTPDTAESLVEKTPD-EAAPLVERTP 314
Cdd:PHA02876   314 MAKNGYD------TENIRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVITLLELGANvNARDYCDKTP 378
Ank_4 pfam13637
Ankyrin repeats (many copies);
74-126 4.29e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 50.35  E-value: 4.29e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2217279355   74 RTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANILI 126
Cdd:pfam13637    2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 64-246 1.46e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 55.27  E-value: 1.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   64 INLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDgehrtplmkALQCHQEACAN--------ILIDSGADINLV 135
Cdd:PHA02878    61 HNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFY---------TLVAIKDAFNNrnveifkiILTNRYKNIQTI 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  136 DVYGNTALHYAVYSEIlSVVAKLLSHGAVIEVHNKASL-TPLLLSITKRSEQIVEFLLIKNANANAVNKYKCTALMLAVC 214
Cdd:PHA02878   132 DLVYIDKKSKDDIIEA-EITKLLLSYGADINMKDRHKGnTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVK 210

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2217279355  215 HGSSEIVGMLLQQNVDVFAADICGVTAEHYAV 246
Cdd:PHA02878   211 HYNKPIVHILLENGASTDARDKCGNTPLHISV 242
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 45-204 1.48e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 55.64  E-value: 1.48e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   45 AASRGQVRKLEKMTKRKKtiNLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANI 124
Cdd:PLN03192   532 VASTGNAALLEELLKAKL--DPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRI 609

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  125 LIDSGAdinLVDVY-GNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAVNK 203
Cdd:PLN03192   610 LYHFAS---ISDPHaAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANT 686


                   .
gi 2217279355  204 Y 204
Cdd:PLN03192   687 D 687
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 52-163 5.53e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.07  E-value: 5.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   52 RKLEKM-TKRKKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANILIDSGA 130
Cdd:PHA02875   113 KKLDIMkLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGA 192

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2217279355  131 DINLVDVYGN-TALHYAVYSEILSVVAKLLSHGA 163
Cdd:PHA02875   193 NIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGA 226
Ank_2 pfam12796
Ankyrin repeats (3 copies);
209-271 7.87e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 48.19  E-value: 7.87e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217279355  209 LMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCGFHHIHEQIMEYIRKLSKNHQNT 271
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGRT 63
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 72-194 2.98e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 2.98e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   72 QKRTALHWACVNGHEEVV-----------------TFLVDRKCQLdVLDGEHrtPLMKALQCHQEACANILIDSGADINL 134
Cdd:cd22192     88 QGETALHIAVVNQNLNLVreliargadvvspratgTFFRPGPKNL-IYYGEH--PLSFAACVGNEEIVRLLIEHGADIRA 164

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217279355  135 VDVYGNTALHYAV-----------YSEILSVVAKLLSHgAVIEVHNKASLTPLLLSITKRSEQIVEFLLIK 194
Cdd:cd22192    165 QDSLGNTVLHILVlqpnktfacqmYDLILSYDKEDDLQ-PLDLVPNNQGLTPFKLAAKEGNIVMFQHLVQK 234
Ank_4 pfam13637
Ankyrin repeats (many copies);
42-93 4.10e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.96  E-value: 4.10e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2217279355   42 IHKAASRGQVRKLEkmTKRKKTINLNIQDAQKRTALHWACVNGHEEVVTFLV 93
Cdd:pfam13637    5 LHAAAASGHLELLR--LLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
92-146 7.33e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 44.26  E-value: 7.33e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217279355   92 LVDRK-CQLDVLDGEHRTPLMKALQCHQEACANILIDSGADINLVDVYGNTALHYA 146
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 152-273 4.82e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.97  E-value: 4.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  152 LSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAVNKYKCTALMLAVCHGSS-----EIVGMLLQ 226
Cdd:PHA03100    15 VKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLE 94

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 2217279355  227 QNVDVFAADICGVTAEHYAVTCGFHHIHeqIMEYirkLSKNHQNTNP 273
Cdd:PHA03100    95 YGANVNAPDNNGITPLLYAISKKSNSYS--IVEY---LLDNGANVNI 136
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 45-247 1.16e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 46.16  E-value: 1.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   45 AASRGQVRKLEKMTKrKKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDrkcqldvldgehrtplmkalqchqeaCANI 124
Cdd:cd22192     24 AAKENDVQAIKKLLK-CPSCDLFQRGALGETALHVAALYDNLEAAVVLME--------------------------AAPE 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  125 LidsgadINLV---DVY-GNTALHYAVYSEILSVVAKLLSHGAVIevhNKASLTPLLLSITKRS-----EQIVEFllikn 195
Cdd:cd22192     77 L------VNEPmtsDLYqGETALHIAVVNQNLNLVRELIARGADV---VSPRATGTFFRPGPKNliyygEHPLSF----- 142

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2217279355  196 ananavnkykctalmlAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVT 247
Cdd:cd22192    143 ----------------AACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVL 178
Ank_4 pfam13637
Ankyrin repeats (many copies);
139-192 1.20e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 1.20e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2217279355  139 GNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLL 192
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
173-225 1.75e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 1.75e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2217279355  173 LTPLLLSITKRSEQIVEFLLIKNANANAVNKYKCTALMLAVCHGSSEIVGMLL 225
Cdd:pfam13637    2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 122-192 2.43e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.27  E-value: 2.43e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217279355  122 ANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLL 192
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 119-272 2.74e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.57  E-value: 2.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  119 EACANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANA 198
Cdd:PHA02874    15 EAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDT 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  199 -----------------------NAVNKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCGFHHIHE 255
Cdd:PHA02874    95 silpipciekdmiktildcgidvNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIK 174

                          170
                   ....*....|....*..
gi 2217279355  256 QIMEYIRKLSKNHQNTN 272
Cdd:PHA02874   175 LLLEKGAYANVKDNNGE 191
PHA02798 PHA02798
ankyrin-like protein; Provisional
 65-231 4.99e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 44.06  E-value: 4.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   65 NLNIQDAQKRTALHWACVNGH---EEVVTFLVDRKCQLDVLDGEHRTPLMKALQ--CH-QEACANILIDSGADINLV-DV 137
Cdd:PHA02798   101 DINKKNSDGETPLYCLLSNGYinnLEILLFMIENGADTTLLDKDGFTMLQVYLQsnHHiDIEIIKLLLEKGVDINTHnNK 180

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  138 YGNTALHYAV---YSEILSVVAKLL-SHGAVIEVHNKAS-------LTPLLLSITKRSEQIVEFLLiKNANANAVNKYKC 206
Cdd:PHA02798   181 EKYDTLHCYFkynIDRIDADILKLFvDNGFIINKENKSHkkkfmeyLNSLLYDNKRFKKNILDFIF-SYIDINQVDELGF 259

                          170       180
                   ....*....|....*....|....*
gi 2217279355  207 TALMLAVCHGSSEIVGMLLQQNVDV 231
Cdd:PHA02798   260 NPLYYSVSHNNRKIFEYLLQLGGDI 284
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 108-249 5.07e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.83  E-value: 5.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  108 TPLMKALQCHQEACANILIDSGA--DINLVDVygNTALHYAVYSEILSVVAKLLSHGAVI-EVHNKASLTPLLLSITKRS 184
Cdd:PHA02875    37 SPIKLAMKFRDSEAIKLLMKHGAipDVKYPDI--ESELHDAVEEGDVKAVEELLDLGKFAdDVFYKDGMTPLHLATILKK 114

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217279355  185 EQIVEFLLIKNANANAVNKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCG 249
Cdd:PHA02875   115 LDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKG 179
Ank_5 pfam13857
Ankyrin repeats (many copies);
192-245 6.74e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.87  E-value: 6.74e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217279355  192 LIKN--ANANAVNKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYA 245
Cdd:pfam13857    1 LLEHgpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_5 pfam13857
Ankyrin repeats (many copies);
64-110 7.37e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 7.37e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2217279355   64 INLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPL 110
Cdd:pfam13857    7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PTZ00121 PTZ00121
MAEBL; Provisional
 536-1038 1.04e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 1.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  536 KAFELKNEQTLRADEilPSESKQKDYEENSWDTESLCETVSQKDVCLPKAAHQKEIDKINGKLEGRYAAEFRtfsamirs 615
Cdd:PTZ00121  1077 KDFDFDAKEDNRADE--ATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEAR-------- 1146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  616 pvkdgllKANCGMKVSIPTKALELMDMQ-TFKAEPPEKPSAFEPAIEMQKsvpnkALEL-KNEQTLRADEILPSESKQKD 693
Cdd:PTZ00121  1147 -------KAEDAKRVEIARKAEDARKAEeARKAEDAKKAEAARKAEEVRK-----AEELrKAEDARKAEAARKAEEERKA 1214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  694 YEESSWDSESLCETVSQKDVCLPKAAHQKEIDKINGKLEGSPVKDGLLKANCGMKVSIptkalelmdmqtfKAEPPEKPS 773
Cdd:PTZ00121  1215 EEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAI-------------KAEEARKAD 1281

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  774 AFEPAIEMQKSVPNKalelKNEQTLRADEILPSESKQKDYEESSWDSEslcETVSQKDVCLPKATHQKEIDKINGKLEES 853
Cdd:PTZ00121  1282 ELKKAEEKKKADEAK----KAEEKKKADEAKKKAEEAKKADEAKKKAE---EAKKKADAAKKKAEEAKKAAEAAKAEAEA 1354

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  854 PDNDgfLKAPCRMKvsiptKALELMdmqtfKAEPPEKPSAFEPAIEMQKsvpnKALELKN---EQTLRADQMFPSESKQK 930
Cdd:PTZ00121  1355 AADE--AEAAEEKA-----EAAEKK-----KEEAKKKADAAKKKAEEKK----KADEAKKkaeEDKKKADELKKAAAAKK 1418

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355  931 KVEENSWDSESLRETVSQKDvcvpKATHQKEMDKISGKLEDSTSLSKILDTVHSCERARELQKDHCEQRTG-----KMEQ 1005
Cdd:PTZ00121  1419 KADEAKKKAEEKKKADEAKK----KAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKAdeakkKAEE 1494

                          490       500       510
                   ....*....|....*....|....*....|...
gi 2217279355 1006 MKKKFCVLKKKLSEAKEIKSQLENQKVKWEQEL 1038
Cdd:PTZ00121  1495 AKKKADEAKKAAEAKKKADEAKKAEEAKKADEA 1527
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 72-101 1.08e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 1.08e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 2217279355    72 QKRTALHWACVNGHEEVVTFLVDRKCQLDV 101
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
207-260 1.14e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.02  E-value: 1.14e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2217279355  207 TALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCGfhhiHEQIMEY 260
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNG----NVEVLKL 52
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 74-103 2.16e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.50  E-value: 2.16e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2217279355   74 RTALHWACV-NGHEEVVTFLVDRKCQLDVLD 103
Cdd:pfam00023    3 NTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 138-170 2.48e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.50  E-value: 2.48e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2217279355  138 YGNTALHYAVYSE-ILSVVAKLLSHGAVIEVHNK 170
Cdd:pfam00023    1 DGNTPLHLAAGRRgNLEIVKLLLSKGADVNARDK 34
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 72-194 2.77e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 41.79  E-value: 2.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217279355   72 QKRTALHWACVNGHEEVVTFLVDRKCQLD---------------VLDGEHrtPLMKALQCHQEACANILIDSGADI---N 133
Cdd:cd21882     72 QGQTALHIAIENRNLNLVRLLVENGADVSaratgrffrkspgnlFYFGEL--PLSLAACTNQEEIVRLLLENGAQPaalE 149

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217279355  134 LVDVYGNTALHYAV----------------YSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIK 194
Cdd:cd21882    150 AQDSLGNTVLHALVlqadntpensafvcqmYNLLLSYGAHLDPTQQLEEIPNHQGLTPLKLAAVEGKIVMFQHILQR 226
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 74-101 4.16e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.70  E-value: 4.16e-03
                           10        20
                   ....*....|....*....|....*...
gi 2217279355   74 RTALHWACVNGHEEVVTFLVDRKCQLDV 101
Cdd:pfam13606    3 NTPLHLAARNGRLEIVKLLLENGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 67-128 4.37e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.04  E-value: 4.37e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217279355   67 NIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTP---------------LMKALQCHQEACANILIDS 128
Cdd:PTZ00322   109 NCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPlelaeengfrevvqlLSRHSQCHFELGANAKPDS 185
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 206-235 7.18e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.34  E-value: 7.18e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2217279355  206 CTALMLAVCH-GSSEIVGMLLQQNVDVFAAD 235
Cdd:pfam00023    3 NTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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