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Conserved domains on  [gi|2217282241|ref|XP_047282699|]
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transforming growth factor beta activator LRRC32 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 7-255 1.52e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd00116:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 319  Bit Score: 147.50  E-value: 1.52e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241   7 VDKKVSCQVLG---LLQVPSVL--PPDTETLDLSGNQLRSI---LASPLGFYTA---LRHLDLSTNEISFLQPGAFQALT 75
Cdd:cd00116    26 QVLRLEGNTLGeeaAKALASALrpQPSLKELCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGPDGCGVLESLL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  76 H---LEHLSLAHNRLA-MATALSAGGLGPL-PRVTSLDLSGNSLYSGLLERLLGEAP---SLHTLSLAENSLT-RLTRHT 146
Cdd:cd00116   106 RsssLQELKLNNNGLGdRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALAKALRanrDLKELNLANNGIGdAGIRAL 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 147 FRDMPA---LEQLDLHSNVLMDIEDGAFEGLPR----LTHLNLSRNSLT--CISDFSLQ------QLRVLDLSCNSIE-- 209
Cdd:cd00116   186 AEGLKAncnLEVLDLNNNGLTDEGASALAETLAslksLEVLNLGDNNLTdaGAAALASAllspniSLLTLSLSCNDITdd 265

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217282241 210 AFQTASQPQAEF-QLTWLDLRENKL------LHFPDLAAL-PRLIYLNLSNNLI 255
Cdd:cd00116   266 GAKDLAEVLAEKeSLLELDLRGNKFgeegaqLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
268-552 1.31e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 1.31e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 268 IHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLD 347
Cdd:COG4886    23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 348 LSHNALETlelgarALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpDEPGPsgcvaFSGITSLRSLS 427
Cdd:COG4886   103 LSGNEELS------NLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLT-----DLPEP-----LGNLTNLKSLD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 428 LVDNEIELLRAGAFLHTPLTELDLSSNPgLEVATGALGGLEaSLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHL 507
Cdd:COG4886   166 LSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2217282241 508 PAWTQAVSLEVLDLRNNSFSLLPGSamGGLeTSLRRLYLQGNPLS 552
Cdd:COG4886   244 PELGNLTNLEELDLSNNQLTDLPPL--ANL-TNLKTLDLSNNQLT 285
PLN03150 super family cl31977
hypothetical protein; Provisional
 474-632 3.69e-04

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03150:

Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 3.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 474 LALQGNGLM-VLQVDLPCFICLKRLNLAENRLSHL--PAWTQAVSLEVLDLRNNSFS-LLPGSAmgGLETSLRRLYLQGN 549
Cdd:PLN03150  423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRGNipPSLGSITSLEVLDLSYNSFNgSIPESL--GQLTSLRILNLNGN 500

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 550 PLSCCGNGWLAAQ-LHQGRVDVDATQDLiCrfssqeevSLSHVRPedCekGGLKNINLIIILTF-ILVSAILLTTLAACC 627
Cdd:PLN03150  501 SLSGRVPAALGGRlLHRASFNFTDNAGL-C--------GIPGLRA--C--GPHLSVGAKIGIAFgVSVAFLFLVICAMCW 567


                  ....*
gi 2217282241 628 CVRRQ 632
Cdd:PLN03150  568 WKRRQ 572
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 7-255 1.52e-39

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 147.50  E-value: 1.52e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241   7 VDKKVSCQVLG---LLQVPSVL--PPDTETLDLSGNQLRSI---LASPLGFYTA---LRHLDLSTNEISFLQPGAFQALT 75
Cdd:cd00116    26 QVLRLEGNTLGeeaAKALASALrpQPSLKELCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGPDGCGVLESLL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  76 H---LEHLSLAHNRLA-MATALSAGGLGPL-PRVTSLDLSGNSLYSGLLERLLGEAP---SLHTLSLAENSLT-RLTRHT 146
Cdd:cd00116   106 RsssLQELKLNNNGLGdRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALAKALRanrDLKELNLANNGIGdAGIRAL 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 147 FRDMPA---LEQLDLHSNVLMDIEDGAFEGLPR----LTHLNLSRNSLT--CISDFSLQ------QLRVLDLSCNSIE-- 209
Cdd:cd00116   186 AEGLKAncnLEVLDLNNNGLTDEGASALAETLAslksLEVLNLGDNNLTdaGAAALASAllspniSLLTLSLSCNDITdd 265

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217282241 210 AFQTASQPQAEF-QLTWLDLRENKL------LHFPDLAAL-PRLIYLNLSNNLI 255
Cdd:cd00116   266 GAKDLAEVLAEKeSLLELDLRGNKFgeegaqLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
14-256 7.62e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.22  E-value: 7.62e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  14 QVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRlamatal 93
Cdd:COG4886    35 LALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  94 sagGLGPLPRVTSLDLSGNSLYSglLERLLGEAPSLHTLSLAENSLTRLTRhTFRDMPALEQLDLHSNVLMDIeDGAFEG 173
Cdd:COG4886   108 ---ELSNLTNLESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGN 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 174 LPRLTHLNLSRNSLTCISD--FSLQQLRVLDLSCNSIEAFqtaSQPQAEF-QLTWLDLRENKLLHFPDLAALPRLIYLNL 250
Cdd:COG4886   181 LTNLKELDLSNNQITDLPEplGNLTNLEELDLSGNQLTDL---PEPLANLtNLETLDLSNNQLTDLPELGNLTNLEELDL 257


                  ....*.
gi 2217282241 251 SNNLIR 256
Cdd:COG4886   258 SNNQLT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
268-552 1.31e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 1.31e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 268 IHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLD 347
Cdd:COG4886    23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 348 LSHNALETlelgarALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpDEPGPsgcvaFSGITSLRSLS 427
Cdd:COG4886   103 LSGNEELS------NLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLT-----DLPEP-----LGNLTNLKSLD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 428 LVDNEIELLRAGAFLHTPLTELDLSSNPgLEVATGALGGLEaSLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHL 507
Cdd:COG4886   166 LSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2217282241 508 PAWTQAVSLEVLDLRNNSFSLLPGSamGGLeTSLRRLYLQGNPLS 552
Cdd:COG4886   244 PELGNLTNLEELDLSNNQLTDLPPL--ANL-TNLKTLDLSNNQLT 285
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 21-473 2.08e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 83.36  E-value: 2.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  21 VPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLamaTALSAGGLGP 100
Cdd:PLN00113  134 IPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL---VGQIPRELGQ 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 101 LPRVTSLDLSGNSLySGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHL 180
Cdd:PLN00113  211 MKSLKWIYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISL 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 181 NLSRNSLTC-ISDF--SLQQLRVLDLSCNSIeafqTASQPQAefqltwldlrenkllhfpdLAALPRLIYLNLSNNliRL 257
Cdd:PLN00113  290 DLSDNSLSGeIPELviQLQNLEILHLFSNNF----TGKIPVA-------------------LTSLPRLQVLQLWSN--KF 344

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 258 PTGPPQDsKGIHapsEGWSALPLSapSGNASGR-PLS-----QLLNLDLSYNEIE-LIPDSfLEHLTSLCFLNLSRNCLR 330
Cdd:PLN00113  345 SGEIPKN-LGKH---NNLTVLDLS--TNNLTGEiPEGlcssgNLFKLILFSNSLEgEIPKS-LGACRSLRRVRLQDNSFS 417

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 331 TFEARRLGSLPCLMLLDLSHN--------------ALETLELGARAL--------GS--LRTLLLQGNALRDLPPYTFAN 386
Cdd:PLN00113  418 GELPSEFTKLPLVYFLDISNNnlqgrinsrkwdmpSLQMLSLARNKFfgglpdsfGSkrLENLDLSRNQFSGAVPRKLGS 497

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 387 LASLQRLNLQGNRVSpcgG--PDEpgpsgcvaFSGITSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGA 463
Cdd:PLN00113  498 LSELMQLKLSENKLS---GeiPDE--------LSSCKKLVSLDLSHNQLSGQIPASFSEMPvLSQLDLSQNQLSGEIPKN 566

                         490
                  ....*....|
gi 2217282241 464 LGGLEASLEV 473
Cdd:PLN00113  567 LGNVESLVQV 576
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 176-401 8.13e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.89  E-value: 8.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 176 RLTHLNLSRNSLTCISDFSL-QQLRVLDLSCN---SIEAFQTASQpqaefqLTWLDLRENKLLHFPDLAALPRLIYLNLS 251
Cdd:cd21340     3 RITHLYLNDKNITKIDNLSLcKNLKVLYLYDNkitKIENLEFLTN------LTHLYLQNNQIEKIENLENLVNLKKLYLG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 252 NNLIRLPTGppqdskgihapsegwsalplsapsgnasgrplsqllnldlsyneielipdsfLEHLTSLCFLNLSRNCLR- 330
Cdd:cd21340    77 GNRISVVEG----------------------------------------------------LENLTNLEELHIENQRLPp 104

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217282241 331 ----TFEARRLGSL-PCLMLLDLSHNALETLElGARALGSLRTLLLQGNALRDLPP--YTFANLASLQRLNLQGNRVS 401
Cdd:cd21340   105 geklTFDPRSLAALsNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 27-552 2.51e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.26  E-value: 2.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  27 PDTETLDLSGNQLRSILASPLgFYT--ALRHLDLSTNEISFLQPGAFqaLTHLEHLSLAHNrlaMATALSAGGLGPLPRV 104
Cdd:PLN00113   93 PYIQTINLSNNQLSGPIPDDI-FTTssSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNN---MLSGEIPNDIGSFSSL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 105 TSLDLSGNSLySGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSR 184
Cdd:PLN00113  167 KVLDLGGNVL-VGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVY 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 185 NSLTCISDFSLQQLRvldlscnsieafqtasqpqaefQLTWLDLRENKLLHF--PDLAALPRLIYLNLSNNLIrlptgpp 262
Cdd:PLN00113  246 NNLTGPIPSSLGNLK----------------------NLQYLFLYQNKLSGPipPSIFSLQKLISLDLSDNSL------- 296

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 263 qdskgihapsegwsalplsapSGNASgRPLSQLLNLDL----SYNEIELIPDSfLEHLTSLCFLNLSRNCLRTFEARRLG 338
Cdd:PLN00113  297 ---------------------SGEIP-ELVIQLQNLEIlhlfSNNFTGKIPVA-LTSLPRLQVLQLWSNKFSGEIPKNLG 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 339 SLPCLMLLDLSHNALE-TLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNrvspcggpdepgpsgcvAF 417
Cdd:PLN00113  354 KHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDN-----------------SF 416

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 418 SGitslrslslvdneiELLRAgaFLHTPLTE-LDLSSNpglevatgalggleaslevlALQGNgLMVLQVDLPCficLKR 496
Cdd:PLN00113  417 SG--------------ELPSE--FTKLPLVYfLDISNN--------------------NLQGR-INSRKWDMPS---LQM 456

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217282241 497 LNLAENRLS-HLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLeTSLRRLYLQGNPLS 552
Cdd:PLN00113  457 LSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSL-SELMQLKLSENKLS 512
LRR_8 pfam13855
Leucine rich repeat;
127-187 6.58e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 6.58e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217282241 127 PSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSL 187
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
293-353 1.09e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.09e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217282241 293 SQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNAL 353
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 474-632 3.69e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 3.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 474 LALQGNGLM-VLQVDLPCFICLKRLNLAENRLSHL--PAWTQAVSLEVLDLRNNSFS-LLPGSAmgGLETSLRRLYLQGN 549
Cdd:PLN03150  423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRGNipPSLGSITSLEVLDLSYNSFNgSIPESL--GQLTSLRILNLNGN 500

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 550 PLSCCGNGWLAAQ-LHQGRVDVDATQDLiCrfssqeevSLSHVRPedCekGGLKNINLIIILTF-ILVSAILLTTLAACC 627
Cdd:PLN03150  501 SLSGRVPAALGGRlLHRASFNFTDNAGL-C--------GIPGLRA--C--GPHLSVGAKIGIAFgVSVAFLFLVICAMCW 567


                  ....*
gi 2217282241 628 CVRRQ 632
Cdd:PLN03150  568 WKRRQ 572
LRRNT smart00013
Leucine rich repeat N-terminal domain;
3-30 9.04e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 34.22  E-value: 9.04e-03
                           10        20
                   ....*....|....*....|....*...
gi 2217282241    3 CPDRVdkkVSCQVLGLLQVPSVLPPDTE 30
Cdd:smart00013   8 CSGTA---VDCSGRGLTEVPLDLPPDTT 32
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 7-255 1.52e-39

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 147.50  E-value: 1.52e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241   7 VDKKVSCQVLG---LLQVPSVL--PPDTETLDLSGNQLRSI---LASPLGFYTA---LRHLDLSTNEISFLQPGAFQALT 75
Cdd:cd00116    26 QVLRLEGNTLGeeaAKALASALrpQPSLKELCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGPDGCGVLESLL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  76 H---LEHLSLAHNRLA-MATALSAGGLGPL-PRVTSLDLSGNSLYSGLLERLLGEAP---SLHTLSLAENSLT-RLTRHT 146
Cdd:cd00116   106 RsssLQELKLNNNGLGdRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALAKALRanrDLKELNLANNGIGdAGIRAL 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 147 FRDMPA---LEQLDLHSNVLMDIEDGAFEGLPR----LTHLNLSRNSLT--CISDFSLQ------QLRVLDLSCNSIE-- 209
Cdd:cd00116   186 AEGLKAncnLEVLDLNNNGLTDEGASALAETLAslksLEVLNLGDNNLTdaGAAALASAllspniSLLTLSLSCNDITdd 265

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217282241 210 AFQTASQPQAEF-QLTWLDLRENKL------LHFPDLAAL-PRLIYLNLSNNLI 255
Cdd:cd00116   266 GAKDLAEVLAEKeSLLELDLRGNKFgeegaqLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
14-256 7.62e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.22  E-value: 7.62e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  14 QVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRlamatal 93
Cdd:COG4886    35 LALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  94 sagGLGPLPRVTSLDLSGNSLYSglLERLLGEAPSLHTLSLAENSLTRLTRhTFRDMPALEQLDLHSNVLMDIeDGAFEG 173
Cdd:COG4886   108 ---ELSNLTNLESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGN 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 174 LPRLTHLNLSRNSLTCISD--FSLQQLRVLDLSCNSIEAFqtaSQPQAEF-QLTWLDLRENKLLHFPDLAALPRLIYLNL 250
Cdd:COG4886   181 LTNLKELDLSNNQITDLPEplGNLTNLEELDLSGNQLTDL---PEPLANLtNLETLDLSNNQLTDLPELGNLTNLEELDL 257


                  ....*.
gi 2217282241 251 SNNLIR 256
Cdd:COG4886   258 SNNQLT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
268-552 1.31e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 1.31e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 268 IHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLD 347
Cdd:COG4886    23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 348 LSHNALETlelgarALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpDEPGPsgcvaFSGITSLRSLS 427
Cdd:COG4886   103 LSGNEELS------NLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLT-----DLPEP-----LGNLTNLKSLD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 428 LVDNEIELLRAGAFLHTPLTELDLSSNPgLEVATGALGGLEaSLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHL 507
Cdd:COG4886   166 LSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2217282241 508 PAWTQAVSLEVLDLRNNSFSLLPGSamGGLeTSLRRLYLQGNPLS 552
Cdd:COG4886   244 PELGNLTNLEELDLSNNQLTDLPPL--ANL-TNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-371 4.79e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 4.79e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  15 VLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALS 94
Cdd:COG4886     9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  95 AGGLGPLPRVTSLDLSGNslysglleRLLGEAPSLHTLSLAENSLTRLTRHtFRDMPALEQLDLHSNVLMDIEDgAFEGL 174
Cdd:COG4886    89 LTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 175 PRLTHLNLSRNSLTCISDF--SLQQLRVLDLSCNSIEAFQTA-SQPQaefQLTWLDLRENKLLHFPD-LAALPRLIYLNL 250
Cdd:COG4886   159 TNLKSLDLSNNQLTDLPEElgNLTNLKELDLSNNQITDLPEPlGNLT---NLEELDLSGNQLTDLPEpLANLTNLETLDL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 251 SNNLIrlptgppqdskgihapsegwSALP-LSApsgnasgrpLSQLLNLDLSYNEIELIPDSFleHLTSLCFLNLSRNCL 329
Cdd:COG4886   236 SNNQL--------------------TDLPeLGN---------LTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2217282241 330 RTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLL 371
Cdd:COG4886   285 TDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-401 7.11e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.44  E-value: 7.11e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 106 SLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRN 185
Cdd:COG4886    27 LLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 186 SLTcisdFSLQQLRVLDLSCNSIEAFQTA-SQPQaefQLTWLDLRENKLLHFPD-LAALPRLIYLNLSNNLIrlptgppq 263
Cdd:COG4886   107 EEL----SNLTNLESLDLSGNQLTDLPEElANLT---NLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQL-------- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 264 dskgihapsegwSALPlsapsgnASGRPLSQLLNLDLSYNEIELIPDSfLEHLTSLCFLNLSRNCLRTFEArRLGSLPCL 343
Cdd:COG4886   172 ------------TDLP-------EELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANLTNL 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217282241 344 MLLDLSHNALETL-ELGarALGSLRTLLLQGNALRDLPPytFANLASLQRLNLQGNRVS 401
Cdd:COG4886   231 ETLDLSNNQLTDLpELG--NLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
223-529 1.60e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.29  E-value: 1.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 223 LTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSY 302
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 303 NEIELIPDSFLEHLTSLCFLNLSRNclrtfeaRRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPy 382
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 383 TFANLASLQRLNLQGNRVSpcggpDEPGPsgcvaFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPgLEVATG 462
Cdd:COG4886   154 PLGNLTNLKSLDLSNNQLT-----DLPEE-----LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQ-LTDLPE 222

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 463 ALGGLEaSLEVLALQGNGLmvlqVDLPCFIC---LKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLL 529
Cdd:COG4886   223 PLANLT-NLETLDLSNNQL----TDLPELGNltnLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 21-473 2.08e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 83.36  E-value: 2.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  21 VPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLamaTALSAGGLGP 100
Cdd:PLN00113  134 IPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL---VGQIPRELGQ 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 101 LPRVTSLDLSGNSLySGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHL 180
Cdd:PLN00113  211 MKSLKWIYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISL 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 181 NLSRNSLTC-ISDF--SLQQLRVLDLSCNSIeafqTASQPQAefqltwldlrenkllhfpdLAALPRLIYLNLSNNliRL 257
Cdd:PLN00113  290 DLSDNSLSGeIPELviQLQNLEILHLFSNNF----TGKIPVA-------------------LTSLPRLQVLQLWSN--KF 344

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 258 PTGPPQDsKGIHapsEGWSALPLSapSGNASGR-PLS-----QLLNLDLSYNEIE-LIPDSfLEHLTSLCFLNLSRNCLR 330
Cdd:PLN00113  345 SGEIPKN-LGKH---NNLTVLDLS--TNNLTGEiPEGlcssgNLFKLILFSNSLEgEIPKS-LGACRSLRRVRLQDNSFS 417

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 331 TFEARRLGSLPCLMLLDLSHN--------------ALETLELGARAL--------GS--LRTLLLQGNALRDLPPYTFAN 386
Cdd:PLN00113  418 GELPSEFTKLPLVYFLDISNNnlqgrinsrkwdmpSLQMLSLARNKFfgglpdsfGSkrLENLDLSRNQFSGAVPRKLGS 497

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 387 LASLQRLNLQGNRVSpcgG--PDEpgpsgcvaFSGITSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGA 463
Cdd:PLN00113  498 LSELMQLKLSENKLS---GeiPDE--------LSSCKKLVSLDLSHNQLSGQIPASFSEMPvLSQLDLSQNQLSGEIPKN 566

                         490
                  ....*....|
gi 2217282241 464 LGGLEASLEV 473
Cdd:PLN00113  567 LGNVESLVQV 576
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
173-507 1.18e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 1.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 173 GLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKllhfpDLAALPRLIYLNLSN 252
Cdd:COG4886    48 LLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 253 NLIrlptgppqdskgihapsegwSALPLSAPSgnasgrpLSQLLNLDLSYNEIELIPDSfLEHLTSLCFLNLSRNCLRTF 332
Cdd:COG4886   123 NQL--------------------TDLPEELAN-------LTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 333 EARrLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpDEPgps 412
Cdd:COG4886   175 PEE-LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLT-----DLP--- 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 413 gcvAFSGITSLRSLSLVDNEIELLRAGAFLhTPLTELDLSSNP--GLEVATGALGGLEASLEVLALQGNGLMVLQVDLPC 490
Cdd:COG4886   245 ---ELGNLTNLEELDLSNNQLTDLPPLANL-TNLKTLDLSNNQltDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                         330
                  ....*....|....*..
gi 2217282241 491 FICLKRLNLAENRLSHL 507
Cdd:COG4886   321 TTLLLLLLLLKGLLVTL 337
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
97-400 4.74e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 72.42  E-value: 4.74e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  97 GLGPLP-----RVTSLDLSGNSLYSgLLERLLGeapSLHTLSLAENSLTRLTRhTFRDmpALEQLDLHSNVLMDIEdgaf 171
Cdd:PRK15370  189 GLTTIPacipeQITTLILDNNELKS-LPENLQG---NIKTLYANSNQLTSIPA-TLPD--TIQEMELSINRITELP---- 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 172 EGLPR-LTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFqtasqPQaefqltwldlrenkllHFPDlaalpRLIYLNL 250
Cdd:PRK15370  258 ERLPSaLQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTL-----PA----------------HLPS-----GITHLNV 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 251 -SNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPsgnasgrplSQLLNLDLSYNEIELIPDSFLEHLTSlcfLNLSRNCL 329
Cdd:PRK15370  312 qSNSLTALPETLPPGLKTLEAGENALTSLPASLP---------PELQVLDVSKNQITVLPETLPPTITT---LDVSRNAL 379

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 330 RTFEArrlgSLP-CLMLLDLSHNALetlelgARALGSLRTLLLQG----NALRDLPPYTFANLASLQRL----NLQGNRV 400
Cdd:PRK15370  380 TNLPE----NLPaALQIMQASRNNL------VRLPESLPHFRGEGpqptRIIVEYNPFSERTIQNMQRLmssvGYQGPRV 449
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
180-529 6.08e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 6.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 180 LNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPT 259
Cdd:COG4886     3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 260 GPPQDSKGIHAPSEGWSALPLSapsGNASGRPLSQLLNLDLSYNEIELIPDSfLEHLTSLCFLNLSRNCLRTFEARrLGS 339
Cdd:COG4886    83 SLLLLGLTDLGDLTNLTELDLS---GNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEP-LGN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 340 LPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpDEPGPsgcvaFSG 419
Cdd:COG4886   158 LTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLT-----DLPEP-----LAN 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 420 ITSLRSLSLVDNEIELLRAGAFLhTPLTELDLSSNPglevatgaLGGLEASLEVLALQgnglmvlqvdlpcficlkRLNL 499
Cdd:COG4886   227 LTNLETLDLSNNQLTDLPELGNL-TNLEELDLSNNQ--------LTDLPPLANLTNLK------------------TLDL 279

                         330       340       350
                  ....*....|....*....|....*....|
gi 2217282241 500 AENRLSHLPAWTQAVSLEVLDLRNNSFSLL 529
Cdd:COG4886   280 SNNQLTDLKLKELELLLGLNSLLLLLLLLN 309
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 176-401 8.13e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.89  E-value: 8.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 176 RLTHLNLSRNSLTCISDFSL-QQLRVLDLSCN---SIEAFQTASQpqaefqLTWLDLRENKLLHFPDLAALPRLIYLNLS 251
Cdd:cd21340     3 RITHLYLNDKNITKIDNLSLcKNLKVLYLYDNkitKIENLEFLTN------LTHLYLQNNQIEKIENLENLVNLKKLYLG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 252 NNLIRLPTGppqdskgihapsegwsalplsapsgnasgrplsqllnldlsyneielipdsfLEHLTSLCFLNLSRNCLR- 330
Cdd:cd21340    77 GNRISVVEG----------------------------------------------------LENLTNLEELHIENQRLPp 104

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217282241 331 ----TFEARRLGSL-PCLMLLDLSHNALETLElGARALGSLRTLLLQGNALRDLPP--YTFANLASLQRLNLQGNRVS 401
Cdd:cd21340   105 geklTFDPRSLAALsNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
3-274 9.37e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 71.27  E-value: 9.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241   3 CPDRVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSIlasPLGFYTALRHLDLSTNEISFLqPGAFQalTHLEHLSL 82
Cdd:PRK15370  175 CLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSL---PENLQGNIKTLYANSNQLTSI-PATLP--DTIQEMEL 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  83 AHNRLamaTALSAgglgPLPR-VTSLDLSGNSLySGLLERLLGEapsLHTLSLAENSLTRLTRHtfrdMPA-LEQLDLHS 160
Cdd:PRK15370  249 SINRI---TELPE----RLPSaLQSLDLFHNKI-SCLPENLPEE---LRYLSVYDNSIRTLPAH----LPSgITHLNVQS 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 161 NVLMDIEdgafEGLP-RLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPqaefQLTWLDLRENKLLHFPDl 239
Cdd:PRK15370  314 NSLTALP----ETLPpGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPP----TITTLDVSRNALTNLPE- 384

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2217282241 240 aALP-RLIYLNLS-NNLIRLPTGPPqdskgiHAPSEG 274
Cdd:PRK15370  385 -NLPaALQIMQASrNNLVRLPESLP------HFRGEG 414
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 27-552 2.51e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.26  E-value: 2.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  27 PDTETLDLSGNQLRSILASPLgFYT--ALRHLDLSTNEISFLQPGAFqaLTHLEHLSLAHNrlaMATALSAGGLGPLPRV 104
Cdd:PLN00113   93 PYIQTINLSNNQLSGPIPDDI-FTTssSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNN---MLSGEIPNDIGSFSSL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 105 TSLDLSGNSLySGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSR 184
Cdd:PLN00113  167 KVLDLGGNVL-VGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVY 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 185 NSLTCISDFSLQQLRvldlscnsieafqtasqpqaefQLTWLDLRENKLLHF--PDLAALPRLIYLNLSNNLIrlptgpp 262
Cdd:PLN00113  246 NNLTGPIPSSLGNLK----------------------NLQYLFLYQNKLSGPipPSIFSLQKLISLDLSDNSL------- 296

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 263 qdskgihapsegwsalplsapSGNASgRPLSQLLNLDL----SYNEIELIPDSfLEHLTSLCFLNLSRNCLRTFEARRLG 338
Cdd:PLN00113  297 ---------------------SGEIP-ELVIQLQNLEIlhlfSNNFTGKIPVA-LTSLPRLQVLQLWSNKFSGEIPKNLG 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 339 SLPCLMLLDLSHNALE-TLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNrvspcggpdepgpsgcvAF 417
Cdd:PLN00113  354 KHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDN-----------------SF 416

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 418 SGitslrslslvdneiELLRAgaFLHTPLTE-LDLSSNpglevatgalggleaslevlALQGNgLMVLQVDLPCficLKR 496
Cdd:PLN00113  417 SG--------------ELPSE--FTKLPLVYfLDISNN--------------------NLQGR-INSRKWDMPS---LQM 456

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217282241 497 LNLAENRLS-HLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLeTSLRRLYLQGNPLS 552
Cdd:PLN00113  457 LSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSL-SELMQLKLSENKLS 512
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 30-188 4.05e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.96  E-value: 4.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  30 ETLDLSGNQLRSIlaSPLGFYTALRHLDLSTNEISFLQPgaFQALTHLEHLSLAHNRLAMATalsagGLGPLPRVTSLDL 109
Cdd:cd21340    27 KVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE-----GLENLTNLEELHI 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 110 SGNSLYSGLL-----ERLLGEAPSLHTLSLAENSLTRLTrhTFRDMPALEQLDLHSNVLMDIED--GAFEGLPRLTHLNL 182
Cdd:cd21340    98 ENQRLPPGEKltfdpRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDL 175


                  ....*.
gi 2217282241 183 SRNSLT 188
Cdd:cd21340   176 TGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
127-187 6.58e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 6.58e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217282241 127 PSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSL 187
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 32-231 1.49e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.42  E-value: 1.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  32 LDLSGNQLRSIlaSPLGFYTALRHLDLSTNEISFLQpgAFQALTHLEHLSLAHNRLamataLSAGGLGPLPRVTSLDLSG 111
Cdd:cd21340     7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQI-----EKIENLENLVNLKKLYLGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 112 NSLysgllERLLGeapsLHTLSlaenSLTRLTrhtfrdmpaLEQLDLHSNVLMDIEDGAFEGL-PRLTHLNLSRNSLTCI 190
Cdd:cd21340    78 NRI-----SVVEG----LENLT----NLEELH---------IENQRLPPGEKLTFDPRSLAALsNSLRVLNISGNNIDSL 135

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2217282241 191 SDFS-LQQLRVLDLSCNSIEAFQTASQP-QAEFQLTWLDLREN 231
Cdd:cd21340   136 EPLApLRNLEQLDASNNQISDLEELLDLlSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
53-114 4.79e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 4.79e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217282241  53 LRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLamaTALSAGGLGPLPRVTSLDLSGNSL 114
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL---TTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 31-210 7.00e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 58.26  E-value: 7.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  31 TLDLSGNQL----RSILASPLGFYTALRHLDLSTNEISflQPGA---FQALTH---LEHLSLAHNRLAMATALS-AGGLG 99
Cdd:COG5238   212 TLWLKRNPIgdegAEILAEALKGNKSLTTLDLSNNQIG--DEGVialAEALKNnttVETLYLSGNQIGAEGAIAlAKALQ 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 100 PLPRVTSLDLSGNSL----YSGLLERLLGEAPsLHTLSLAENSLT----RLTRHTFRDMPALEQLDLHSNVLMDIEDGAF 171
Cdd:COG5238   290 GNTTLTSLDLSVNRIgdegAIALAEGLQGNKT-LHTLNLAYNGIGaqgaIALAKALQENTTLHSLDLSDNQIGDEGAIAL 368

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2217282241 172 ----EGLPRLTHLNLSRNSLT------CISDFSLQQLRVLDLSCNSIEA 210
Cdd:COG5238   369 akylEGNTTLRELNLGKNNIGkqgaeaLIDALQTNRLHTLILDGNLIGA 417
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 128-374 8.82e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.33  E-value: 8.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 128 SLHTLSLAENSLTRLTRhtFRDMPALEQLDLHSNVLMDIEDgaFEGLPRLTHLNLSRNSLTCISDF-SLQQLRVLDLSCN 206
Cdd:cd21340     3 RITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLeNLVNLKKLYLGGN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 207 SIEAFqtasqpqaefqltwldlrENkllhfpdLAALPRLIYLNLSNNliRLPTGppqdskgihapsegwsalplsapsgn 286
Cdd:cd21340    79 RISVV------------------EG-------LENLTNLEELHIENQ--RLPPG-------------------------- 105

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 287 asgrplsqllnldlsyNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEArrLGSLPCLMLLDLSHNAL---ETLELGARAL 363
Cdd:cd21340   106 ----------------EKLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIsdlEELLDLLSSW 167

                         250
                  ....*....|.
gi 2217282241 364 GSLRTLLLQGN 374
Cdd:cd21340   168 PSLRELDLTGN 178
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 30-177 1.16e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 57.88  E-value: 1.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  30 ETLDLSGNQLRS----ILASPLGFYTALRHLDLSTNEISFlqPGAFQALTHLEH------LSLAHNRL------AMATAL 93
Cdd:COG5238   267 ETLYLSGNQIGAegaiALAKALQGNTTLTSLDLSVNRIGD--EGAIALAEGLQGnktlhtLNLAYNGIgaqgaiALAKAL 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  94 SAGglgplPRVTSLDLSGNSLY---SGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDM---PALEQLDLHSNVL-MDI 166
Cdd:COG5238   345 QEN-----TTLHSLDLSDNQIGdegAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAlqtNRLHTLILDGNLIgAEA 419

                         170
                  ....*....|.
gi 2217282241 167 EDGAFEGLPRL 177
Cdd:COG5238   420 QQRLEQLLERI 430
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 292-455 5.81e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 5.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 292 LSQLLNLDLSY---NEIELIPDsfLEHLTSLCFLNLSRNCLRTFEarRLGSLPCLMLLDLSHNALETLElGARALGSLRT 368
Cdd:cd21340    20 LSLCKNLKVLYlydNKITKIEN--LEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVE-GLENLTNLEE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 369 LLLQGNALRDLPPYTF-----ANLA-SLQRLNLQGNRVspcggpDEPGPsgcvaFSGITSLRSLSLVDNEIELLR--AGA 440
Cdd:cd21340    95 LHIENQRLPPGEKLTFdprslAALSnSLRVLNISGNNI------DSLEP-----LAPLRNLEQLDASNNQISDLEelLDL 163

                         170
                  ....*....|....*.
gi 2217282241 441 FLHTP-LTELDLSSNP 455
Cdd:cd21340   164 LSSWPsLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
151-208 9.68e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 9.68e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217282241 151 PALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISD---FSLQQLRVLDLSCNSI 208
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgafSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
293-353 1.09e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.09e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217282241 293 SQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNAL 353
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 365-530 1.46e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.48  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 365 SLRTLLLQGNALRDLPPytFANLASLQRLNLQGNRVSPCGGpdepgpsgcvaFSGITSLRSLSLVDNEIELLrAGafLH- 443
Cdd:cd21340    25 NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN-----------LENLVNLKKLYLGGNRISVV-EG--LEn 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 444 -TPLTELDLS-----SNPGLEVATGALGGLEASLEVLALQGNGLMVLQvDLPCFICLKRLNLAENRLSHLPAWTQAVS-- 515
Cdd:cd21340    89 lTNLEELHIEnqrlpPGEKLTFDPRSLAALSNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEELLDLLSsw 167

                         170
                  ....*....|....*..
gi 2217282241 516 --LEVLDLRNNSFSLLP 530
Cdd:cd21340   168 psLRELDLTGNPVCKKP 184
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
275-551 2.40e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.93  E-value: 2.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 275 WSALPLSAPSGNASGRPLS-QLLNLDLSYNEIEL---------IPDSFLEHLTSLCF-----LNLSRNC---LRTFEAR- 335
Cdd:PRK15370  150 WSEWVKEAPAKEAANREEAvQRMRDCLKNNKTELrlkilglttIPACIPEQITTLILdnnelKSLPENLqgnIKTLYANs 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 336 -RLGSLP-----CLMLLDLSHNALetLELGARALGSLRTLLLQGNALRDLPPytfanlaslqrlNLqgnrvspcggPDEp 409
Cdd:PRK15370  230 nQLTSIPatlpdTIQEMELSINRI--TELPERLPSALQSLDLFHNKISCLPE------------NL----------PEE- 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 410 gpsgcvafsgitsLRSLSLVDNEIELLRAgaflHTPlteldlssnpglevatgalggleASLEVLALQGNGLMVLQVDLP 489
Cdd:PRK15370  285 -------------LRYLSVYDNSIRTLPA----HLP-----------------------SGITHLNVQSNSLTALPETLP 324

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217282241 490 cfICLKRLNLAENRLSHLPAwTQAVSLEVLDLRNNSFSLLPGSamggLETSLRRLYLQGNPL 551
Cdd:PRK15370  325 --PGLKTLEAGENALTSLPA-SLPPELQVLDVSKNQITVLPET----LPPTITTLDVSRNAL 379
LRR_8 pfam13855
Leucine rich repeat;
30-87 3.02e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 3.02e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2217282241  30 ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRL 87
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
17-341 5.13e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 52.86  E-value: 5.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  17 GLLQVPSVLPPDTETLDLSGNQLRSILASPlgfyTALRHLDLSTNEIS---FLQPGafqalthLEHLSLAHNRLAMATAL 93
Cdd:PRK15387  212 GLTTLPDCLPAHITTLVIPDNNLTSLPALP----PELRTLEVSGNQLTslpVLPPG-------LLELSIFSNPLTHLPAL 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  94 SAGglgplprVTSLDLSGNSLYSgllerLLGEAPSLHTLSLAENSLTRLtrhtfrdmPALEQldlhsnvlmdiedgafeg 173
Cdd:PRK15387  281 PSG-------LCKLWIFGNQLTS-----LPVLPPGLQELSVSDNQLASL--------PALPS------------------ 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 174 lpRLTHLNLSRNSLTCISDF--SLQQLRVLDlscnsieaFQTASQPQAEFQLTWLDLRENKLLHFPDL-AALPRLIYlnL 250
Cdd:PRK15387  323 --ELCKLWAYNNQLTSLPTLpsGLQELSVSD--------NQLASLPTLPSELYKLWAYNNRLTSLPALpSGLKELIV--S 390

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 251 SNNLIRLPTgPPQDSKGIHAPSEGWSALPLsAPSGnasgrplsqLLNLDLSYNEIELIPDSFLeHLTSLCFLNLSRNCL- 329
Cdd:PRK15387  391 GNRLTSLPV-LPSELKELMVSGNRLTSLPM-LPSG---------LLSLSVYRNQLTRLPESLI-HLSSETTVNLEGNPLs 458

                         330
                  ....*....|....
gi 2217282241 330 -RTFEA-RRLGSLP 341
Cdd:PRK15387  459 eRTLQAlREITSAP 472
LRR_8 pfam13855
Leucine rich repeat;
343-400 1.02e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.02e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217282241 343 LMLLDLSHNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRV 400
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 78-364 4.51e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.40  E-value: 4.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  78 EHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERL---LGEAPSLHTLSLAENSLTRLTRHTFRDM---- 150
Cdd:COG5238   156 VHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELaeaLTQNTTVTTLWLKRNPIGDEGAEILAEAlkgn 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 151 PALEQLDLHSNvlmDIEDGAFEGLprLTHLNLSRnsltcisdfslqQLRVLDLSCNSIE---AFQTASQPQAEFQLTWLD 227
Cdd:COG5238   236 KSLTTLDLSNN---QIGDEGVIAL--AEALKNNT------------TVETLYLSGNQIGaegAIALAKALQGNTTLTSLD 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 228 LRENKLlHFPDLAAL-------PRLIYLNLSNNLIRlptgppqdskgihapSEGWSALPlsapsgnASGRPLSQLLNLDL 300
Cdd:COG5238   299 LSVNRI-GDEGAIALaeglqgnKTLHTLNLAYNGIG---------------AQGAIALA-------KALQENTTLHSLDL 355

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 301 SYNEI------ELIpdSFLEHLTSLCFLNLSRNCLRTFEARRLGSLpclmlldLSHNALETLELGARALG 364
Cdd:COG5238   356 SDNQIgdegaiALA--KYLEGNTTLRELNLGKNNIGKQGAEALIDA-------LQTNRLHTLILDGNLIG 416
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 32-157 2.38e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 2.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  32 LDLSGNQLRSIlaSPLGFYTALRHLDLSTNEISFLQpgAFQALTHLEHLSLAHNRLA----------MATALSA------ 95
Cdd:cd21340    51 LYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPpgekltfdprSLAALSNslrvln 126

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217282241  96 ---------GGLGPLPRVTSLDLSGNSLYSGL-LERLLGEAPSLHTLSLAENSLTRLTRhtFRD-----MPALEQLD 157
Cdd:cd21340   127 isgnnidslEPLAPLRNLEQLDASNNQISDLEeLLDLLSSWPSLRELDLTGNPVCKKPK--YRDkiilaSKSLEVLD 201
PLN03150 PLN03150
hypothetical protein; Provisional
 308-401 2.48e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.50  E-value: 2.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 308 IPD--SFLEHLTSLcflNLSRNCLRTFEARRLGSLPCLMLLDLSHNALEtlelgaralGSLrtlllqgnalrdlpPYTFA 385
Cdd:PLN03150  434 IPNdiSKLRHLQSI---NLSGNSIRGNIPPSLGSITSLEVLDLSYNSFN---------GSI--------------PESLG 487

                          90
                  ....*....|....*.
gi 2217282241 386 NLASLQRLNLQGNRVS 401
Cdd:PLN03150  488 QLTSLRILNLNGNSLS 503
LRR_8 pfam13855
Leucine rich repeat;
365-433 3.07e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.07e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217282241 365 SLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNR---VSPcggpdepgpsgcVAFSGITSLRSLSLVDNEI 433
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLlttLSP------------GAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 322-555 4.55e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.81  E-value: 4.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 322 LNLSRNCLRTFEARRL-GSLPCLMLLDLSHNALETLELGA-----RALGSLRTLLLQGNALRDLPPYT------FANLAS 389
Cdd:cd00116     3 LSLKGELLKTERATELlPKLLCLQVLRLEGNTLGEEAAKAlasalRPQPSLKELCLSLNETGRIPRGLqsllqgLTKGCG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 390 LQRLNLQGNRVSPcggpdePGPSGCVAFSGITSLRSLSLVDNEIELlRAGAFLHT-------PLTELDLS----SNPGLE 458
Cdd:cd00116    83 LQELDLSDNALGP------DGCGVLESLLRSSSLQELKLNNNGLGD-RGLRLLAKglkdlppALEKLVLGrnrlEGASCE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 459 VATGALGGLeASLEVL-----ALQGNGLMVLQVDLPCFICLKRLNLAENRLSHL------PAWTQAVSLEVLDLRNNSFS 527
Cdd:cd00116   156 ALAKALRAN-RDLKELnlannGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEgasalaETLASLKSLEVLNLGDNNLT 234

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2217282241 528 LLP----GSAMGGLETSLRRLYLQGNPLSCCG 555
Cdd:cd00116   235 DAGaaalASALLSPNISLLTLSLSCNDITDDG 266
LRR_8 pfam13855
Leucine rich repeat;
494-551 5.26e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 5.26e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 494 LKRLNLAENRLSHLP--AWTQAVSLEVLDLRNNSFSLLPGSAMGGLeTSLRRLYLQGNPL 551
Cdd:pfam13855   3 LRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 290-527 1.01e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.65  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 290 RPLSQLLNLDLSYNEIELIPD------SFLEHLTSLCFLNLSRNCLRTFEARRLGSL---PCLMLLDLSHNALET--LEL 358
Cdd:cd00116    48 RPQPSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDrgLRL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 359 GARALGS----LRTLLLQGNALRDLPPYTFANLA----SLQRLNLQGNRVSPCGGPdepgpSGCVAFSGITSLRSLSLVD 430
Cdd:cd00116   128 LAKGLKDlppaLEKLVLGRNRLEGASCEALAKALranrDLKELNLANNGIGDAGIR-----ALAEGLKANCNLEVLDLNN 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 431 NEIELLRAGAFLHTP-----LTELDLSSNPGLEVATGALggLEASLEVLalqgnglmvlqvdlpcfICLKRLNLAENRLS 505
Cdd:cd00116   203 NGLTDEGASALAETLaslksLEVLNLGDNNLTDAGAAAL--ASALLSPN-----------------ISLLTLSLSCNDIT 263

                         250       260
                  ....*....|....*....|....*...
gi 2217282241 506 HLPAWTQA------VSLEVLDLRNNSFS 527
Cdd:cd00116   264 DDGAKDLAevlaekESLLELDLRGNKFG 291
PLN03150 PLN03150
hypothetical protein; Provisional
 30-113 2.32e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 2.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  30 ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLgPLPRvTSLDL 109
Cdd:PLN03150  445 QSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGR-LLHR-ASFNF 522


                  ....
gi 2217282241 110 SGNS 113
Cdd:PLN03150  523 TDNA 526
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 193-454 2.50e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 2.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 193 FSLQQLRVLDLSCNSI---EAFQTASQPQAEFQLTWLDLRENKLLHFPD--------LAALPRLIYLNLSNNLIrLPTGP 261
Cdd:cd00116    20 PKLLCLQVLRLEGNTLgeeAAKALASALRPQPSLKELCLSLNETGRIPRglqsllqgLTKGCGLQELDLSDNAL-GPDGC 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 262 PqdskgihapseGWSALPLSapsgnasgrplSQLLNLDLSYNEIE-----LIPDSFLEHLTSLCFLNLSRNCLRTFEARR 336
Cdd:cd00116    99 G-----------VLESLLRS-----------SSLQELKLNNNGLGdrglrLLAKGLKDLPPALEKLVLGRNRLEGASCEA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 337 LGSL----PCLMLLDLSHNAL-----ETLELGARALGSLRTLLLQGNALRDLP----PYTFANLASLQRLNLQGNRVSpc 403
Cdd:cd00116   157 LAKAlranRDLKELNLANNGIgdagiRALAEGLKANCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLT-- 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217282241 404 ggpDEPGPSGCVAF-SGITSLRSLSLVDNEIELLRAGAFLH-----TPLTELDLSSN 454
Cdd:cd00116   235 ---DAGAAALASALlSPNISLLTLSLSCNDITDDGAKDLAEvlaekESLLELDLRGN 288
PLN03150 PLN03150
hypothetical protein; Provisional
 474-632 3.69e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 3.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 474 LALQGNGLM-VLQVDLPCFICLKRLNLAENRLSHL--PAWTQAVSLEVLDLRNNSFS-LLPGSAmgGLETSLRRLYLQGN 549
Cdd:PLN03150  423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRGNipPSLGSITSLEVLDLSYNSFNgSIPESL--GQLTSLRILNLNGN 500

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 550 PLSCCGNGWLAAQ-LHQGRVDVDATQDLiCrfssqeevSLSHVRPedCekGGLKNINLIIILTF-ILVSAILLTTLAACC 627
Cdd:PLN03150  501 SLSGRVPAALGGRlLHRASFNFTDNAGL-C--------GIPGLRA--C--GPHLSVGAKIGIAFgVSVAFLFLVICAMCW 567


                  ....*
gi 2217282241 628 CVRRQ 632
Cdd:PLN03150  568 WKRRQ 572
PLN03150 PLN03150
hypothetical protein; Provisional
 32-130 1.06e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.11  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241  32 LDLSGNQLRSILASPLgfyTALRHL---DLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRvtsLD 108
Cdd:PLN03150  423 LGLDNQGLRGFIPNDI---SKLRHLqsiNLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRI---LN 496

                          90       100
                  ....*....|....*....|..
gi 2217282241 109 LSGNSLySGLLERLLGEAPsLH 130
Cdd:PLN03150  497 LNGNSL-SGRVPAALGGRL-LH 516
LRR_8 pfam13855
Leucine rich repeat;
421-481 3.21e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 3.21e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217282241 421 TSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLeASLEVLALQGNGL 481
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSnLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
175-233 3.76e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 3.76e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217282241 175 PRLTHLNLSRNSLTCISD---FSLQQLRVLDLSCNSIEAFqtasqPQAEFQ----LTWLDLRENKL 233
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgafKGLSNLKVLDLSNNLLTTL-----SPGAFSglpsLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 238-341 5.37e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.80  E-value: 5.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282241 238 DLAALPRLIYLNLSNNLIRlptgppqdskgihapsegwSALPLSApsGNASGrplsqLLNLDLSYNEIE-LIPDSfLEHL 316
Cdd:PLN03150  437 DISKLRHLQSINLSGNSIR-------------------GNIPPSL--GSITS-----LEVLDLSYNSFNgSIPES-LGQL 489

                          90       100
                  ....*....|....*....|....*
gi 2217282241 317 TSLCFLNLSRNCLRTFEARRLGSLP 341
Cdd:PLN03150  490 TSLRILNLNGNSLSGRVPAALGGRL 514
LRRNT smart00013
Leucine rich repeat N-terminal domain;
3-30 9.04e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 34.22  E-value: 9.04e-03
                           10        20
                   ....*....|....*....|....*...
gi 2217282241    3 CPDRVdkkVSCQVLGLLQVPSVLPPDTE 30
Cdd:smart00013   8 CSGTA---VDCSGRGLTEVPLDLPPDTT 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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