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Conserved domains on  [gi|2217285140|ref|XP_047283703|]
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transforming growth factor beta regulator 1 isoform X2 [Homo sapiens]

Protein Classification

FYRN and FYRC domain-containing protein( domain architecture ID 10532225)

FYRN and FYRC domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FYRC pfam05965
F/Y rich C-terminus; This region is normally found in the trithorax/ALL1 family proteins. It ...
 93-174 9.99e-25

F/Y rich C-terminus; This region is normally found in the trithorax/ALL1 family proteins. It is similar to SMART:SM00542.


:

Pssm-ID: 461788  Cd Length: 83  Bit Score: 93.83  E-value: 9.99e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217285140  93 QPQFEIVPEDDPQNAIVSSSADACHAELLRTI----STTMGKLMPNLLPAGADFFGFSHPAIHNLIQSCPGARKCINYqw 168
Cdd:pfam05965   1 GPLFRVTVEEDPDESFEGSSPTKCWSMVLERVqelrREAGLKLKLPESISGEDMFGLTHPAVVRLIESLPGAEKCTNY-- 78


                  ....*.
gi 2217285140 169 vKFDVC 174
Cdd:pfam05965  79 -KFRYG 83
FYRN pfam05964
F/Y-rich N-terminus; This region is normally found in the trithorax/ALL1 family proteins. It ...
 46-87 5.14e-21

F/Y-rich N-terminus; This region is normally found in the trithorax/ALL1 family proteins. It is similar to SMART:SM00541.


:

Pssm-ID: 461787  Cd Length: 51  Bit Score: 83.32  E-value: 5.14e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2217285140  46 KIITDRPGFHDESAIYPVGYCSTRIYASMKCPDQKCLYTCQI 87
Cdd:pfam05964  10 EIVPDRPAFHTERYIYPVGYKSTRLYWSTKDPRKRCRYTCEI 51
 
Name Accession Description Interval E-value
FYRC pfam05965
F/Y rich C-terminus; This region is normally found in the trithorax/ALL1 family proteins. It ...
 93-174 9.99e-25

F/Y rich C-terminus; This region is normally found in the trithorax/ALL1 family proteins. It is similar to SMART:SM00542.


Pssm-ID: 461788  Cd Length: 83  Bit Score: 93.83  E-value: 9.99e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217285140  93 QPQFEIVPEDDPQNAIVSSSADACHAELLRTI----STTMGKLMPNLLPAGADFFGFSHPAIHNLIQSCPGARKCINYqw 168
Cdd:pfam05965   1 GPLFRVTVEEDPDESFEGSSPTKCWSMVLERVqelrREAGLKLKLPESISGEDMFGLTHPAVVRLIESLPGAEKCTNY-- 78


                  ....*.
gi 2217285140 169 vKFDVC 174
Cdd:pfam05965  79 -KFRYG 83
FYRN pfam05964
F/Y-rich N-terminus; This region is normally found in the trithorax/ALL1 family proteins. It ...
 46-87 5.14e-21

F/Y-rich N-terminus; This region is normally found in the trithorax/ALL1 family proteins. It is similar to SMART:SM00541.


Pssm-ID: 461787  Cd Length: 51  Bit Score: 83.32  E-value: 5.14e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2217285140  46 KIITDRPGFHDESAIYPVGYCSTRIYASMKCPDQKCLYTCQI 87
Cdd:pfam05964  10 EIVPDRPAFHTERYIYPVGYKSTRLYWSTKDPRKRCRYTCEI 51
FYRN smart00541
FY-rich domain, N-terminal region; is sometimes closely juxtaposed with the C-terminal region ...
 46-89 2.17e-16

FY-rich domain, N-terminal region; is sometimes closely juxtaposed with the C-terminal region (FYRC), but sometimes is far distant. Unknown function, but occurs frequently in chromatin-associated proteins.


Pssm-ID: 128814  Cd Length: 44  Bit Score: 70.78  E-value: 2.17e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2217285140   46 KIITDRPGFHDESAIYPVGYCSTRIYASMKCPDQKCLYTCQIKD 89
Cdd:smart00541   1 LLPIQGKLFHSESAIFPVGYKSTRKYWSVKDPNRRCLYSCVIDE 44
FYRC smart00542
FY-rich domain, C-terminal region; is sometimes closely juxtaposed with the N-terminal region ...
 95-167 2.91e-11

FY-rich domain, C-terminal region; is sometimes closely juxtaposed with the N-terminal region (FYRN), but sometimes is far distant. Unknown function, but occurs frequently in chromatin-associated proteins.


Pssm-ID: 197781  Cd Length: 86  Bit Score: 58.07  E-value: 2.91e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217285140   95 QFEIVPEDDPQNAIVSSSADACHAELLRTISTTMGKL-MPNLLPA---GADFFGFSHPAIHNLIQSCPGARKCINYQ 167
Cdd:smart00542   1 LFRVEIESDPGEVFKGESPEKCWEMVLERVQEARIAAdLLQLLPEgvsGEEMFGLSSPAVVKLIEALPGVHQCTNYW 77
 
Name Accession Description Interval E-value
FYRC pfam05965
F/Y rich C-terminus; This region is normally found in the trithorax/ALL1 family proteins. It ...
 93-174 9.99e-25

F/Y rich C-terminus; This region is normally found in the trithorax/ALL1 family proteins. It is similar to SMART:SM00542.


Pssm-ID: 461788  Cd Length: 83  Bit Score: 93.83  E-value: 9.99e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217285140  93 QPQFEIVPEDDPQNAIVSSSADACHAELLRTI----STTMGKLMPNLLPAGADFFGFSHPAIHNLIQSCPGARKCINYqw 168
Cdd:pfam05965   1 GPLFRVTVEEDPDESFEGSSPTKCWSMVLERVqelrREAGLKLKLPESISGEDMFGLTHPAVVRLIESLPGAEKCTNY-- 78


                  ....*.
gi 2217285140 169 vKFDVC 174
Cdd:pfam05965  79 -KFRYG 83
FYRN pfam05964
F/Y-rich N-terminus; This region is normally found in the trithorax/ALL1 family proteins. It ...
 46-87 5.14e-21

F/Y-rich N-terminus; This region is normally found in the trithorax/ALL1 family proteins. It is similar to SMART:SM00541.


Pssm-ID: 461787  Cd Length: 51  Bit Score: 83.32  E-value: 5.14e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2217285140  46 KIITDRPGFHDESAIYPVGYCSTRIYASMKCPDQKCLYTCQI 87
Cdd:pfam05964  10 EIVPDRPAFHTERYIYPVGYKSTRLYWSTKDPRKRCRYTCEI 51
FYRN smart00541
FY-rich domain, N-terminal region; is sometimes closely juxtaposed with the C-terminal region ...
 46-89 2.17e-16

FY-rich domain, N-terminal region; is sometimes closely juxtaposed with the C-terminal region (FYRC), but sometimes is far distant. Unknown function, but occurs frequently in chromatin-associated proteins.


Pssm-ID: 128814  Cd Length: 44  Bit Score: 70.78  E-value: 2.17e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2217285140   46 KIITDRPGFHDESAIYPVGYCSTRIYASMKCPDQKCLYTCQIKD 89
Cdd:smart00541   1 LLPIQGKLFHSESAIFPVGYKSTRKYWSVKDPNRRCLYSCVIDE 44
FYRC smart00542
FY-rich domain, C-terminal region; is sometimes closely juxtaposed with the N-terminal region ...
 95-167 2.91e-11

FY-rich domain, C-terminal region; is sometimes closely juxtaposed with the N-terminal region (FYRN), but sometimes is far distant. Unknown function, but occurs frequently in chromatin-associated proteins.


Pssm-ID: 197781  Cd Length: 86  Bit Score: 58.07  E-value: 2.91e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217285140   95 QFEIVPEDDPQNAIVSSSADACHAELLRTISTTMGKL-MPNLLPA---GADFFGFSHPAIHNLIQSCPGARKCINYQ 167
Cdd:smart00542   1 LFRVEIESDPGEVFKGESPEKCWEMVLERVQEARIAAdLLQLLPEgvsGEEMFGLSSPAVVKLIEALPGVHQCTNYW 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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