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Conserved domains on  [gi|2217285481|ref|XP_047283812|]
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U4/U6.U5 tri-snRNP-associated protein 1 isoform X1 [Homo sapiens]

Protein Classification

SNU66/SART1 family protein( domain architecture ID 18337532)

SNU66/SART1 family protein similar to human U4/U6.U5 tri-snRNP-associated protein 1, also called squamous cell carcinoma antigen recognized by T-cells 1 (SART-1), that plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome

Gene Ontology:  GO:0000398|GO:0046540|GO:0005681
PubMed:  11350945

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SART-1 pfam03343
SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has ...
 165-399 4.22e-63

SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has been shown to be a component of U4/U6 x U5 tri-snRNP complex in human, Schizosaccharomyces pombe and Saccharomyces cerevisiae. SART-1 is a known tumour antigen in a range of cancers recognized by T cells.


:

Pssm-ID: 460888 [Multi-domain]  Cd Length: 569  Bit Score: 216.44  E-value: 4.22e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217285481 165 EELREKLAAAKEKRLLNQKLgKIKTLGEDDpWLDDTAAWIERSRQLQKEkdlaEKRAKLLEeMDQEFGvstlvEEEFGQR 244
Cdd:pfam03343   1 EELKEKIKKAREKRERNAKL-EGKGLGEDD-EDDDAKAWVKKSKKRQKA----IAKAKARE-LEEELG-----EEEAEKA 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217285481 245 RQDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVL-QEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVd 323
Cdd:pfam03343  69 AQAEYTSKDLAGLKVGHDLDDFLEGEEQILTLKDTGVLlDEEEDELENVNLAEKEKLKKNLELKKKKPGYDPYDDDEDG- 147

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217285481 324 dlaqQKPRSILSKYDEELEG-ERPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTF 399
Cdd:pfam03343 148 ----EGEKGILSKYDEEIDGkKKKKGFTLDGQGSTAEEREALAEEIAEKLKKQLLSLDYLKLEPASDYLDESEIFKF 220
HIND pfam19252
HIND motif; The Hub1 interacting motif (HIND) is a short motif found in 1 to 3 copies in ...
 117-137 3.83e-07

HIND motif; The Hub1 interacting motif (HIND) is a short motif found in 1 to 3 copies in spliceosomal proteins such as Snu66. The motif is bound by the Hub1 protein.


:

Pssm-ID: 466011  Cd Length: 22  Bit Score: 46.30  E-value: 3.83e-07
                          10        20
                  ....*....|....*....|.
gi 2217285481 117 SLSIEETNKLRAKLGLKPLEV 137
Cdd:pfam19252   2 SLSIEETNKLRASLGLKPIPV 22
 
Name Accession Description Interval E-value
SART-1 pfam03343
SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has ...
 165-399 4.22e-63

SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has been shown to be a component of U4/U6 x U5 tri-snRNP complex in human, Schizosaccharomyces pombe and Saccharomyces cerevisiae. SART-1 is a known tumour antigen in a range of cancers recognized by T cells.


Pssm-ID: 460888 [Multi-domain]  Cd Length: 569  Bit Score: 216.44  E-value: 4.22e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217285481 165 EELREKLAAAKEKRLLNQKLgKIKTLGEDDpWLDDTAAWIERSRQLQKEkdlaEKRAKLLEeMDQEFGvstlvEEEFGQR 244
Cdd:pfam03343   1 EELKEKIKKAREKRERNAKL-EGKGLGEDD-EDDDAKAWVKKSKKRQKA----IAKAKARE-LEEELG-----EEEAEKA 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217285481 245 RQDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVL-QEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVd 323
Cdd:pfam03343  69 AQAEYTSKDLAGLKVGHDLDDFLEGEEQILTLKDTGVLlDEEEDELENVNLAEKEKLKKNLELKKKKPGYDPYDDDEDG- 147

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217285481 324 dlaqQKPRSILSKYDEELEG-ERPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTF 399
Cdd:pfam03343 148 ----EGEKGILSKYDEEIDGkKKKKGFTLDGQGSTAEEREALAEEIAEKLKKQLLSLDYLKLEPASDYLDESEIFKF 220
HIND pfam19252
HIND motif; The Hub1 interacting motif (HIND) is a short motif found in 1 to 3 copies in ...
 117-137 3.83e-07

HIND motif; The Hub1 interacting motif (HIND) is a short motif found in 1 to 3 copies in spliceosomal proteins such as Snu66. The motif is bound by the Hub1 protein.


Pssm-ID: 466011  Cd Length: 22  Bit Score: 46.30  E-value: 3.83e-07
                          10        20
                  ....*....|....*....|.
gi 2217285481 117 SLSIEETNKLRAKLGLKPLEV 137
Cdd:pfam19252   2 SLSIEETNKLRASLGLKPIPV 22
 
Name Accession Description Interval E-value
SART-1 pfam03343
SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has ...
 165-399 4.22e-63

SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has been shown to be a component of U4/U6 x U5 tri-snRNP complex in human, Schizosaccharomyces pombe and Saccharomyces cerevisiae. SART-1 is a known tumour antigen in a range of cancers recognized by T cells.


Pssm-ID: 460888 [Multi-domain]  Cd Length: 569  Bit Score: 216.44  E-value: 4.22e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217285481 165 EELREKLAAAKEKRLLNQKLgKIKTLGEDDpWLDDTAAWIERSRQLQKEkdlaEKRAKLLEeMDQEFGvstlvEEEFGQR 244
Cdd:pfam03343   1 EELKEKIKKAREKRERNAKL-EGKGLGEDD-EDDDAKAWVKKSKKRQKA----IAKAKARE-LEEELG-----EEEAEKA 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217285481 245 RQDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVL-QEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVd 323
Cdd:pfam03343  69 AQAEYTSKDLAGLKVGHDLDDFLEGEEQILTLKDTGVLlDEEEDELENVNLAEKEKLKKNLELKKKKPGYDPYDDDEDG- 147

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217285481 324 dlaqQKPRSILSKYDEELEG-ERPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTF 399
Cdd:pfam03343 148 ----EGEKGILSKYDEEIDGkKKKKGFTLDGQGSTAEEREALAEEIAEKLKKQLLSLDYLKLEPASDYLDESEIFKF 220
HIND pfam19252
HIND motif; The Hub1 interacting motif (HIND) is a short motif found in 1 to 3 copies in ...
 117-137 3.83e-07

HIND motif; The Hub1 interacting motif (HIND) is a short motif found in 1 to 3 copies in spliceosomal proteins such as Snu66. The motif is bound by the Hub1 protein.


Pssm-ID: 466011  Cd Length: 22  Bit Score: 46.30  E-value: 3.83e-07
                          10        20
                  ....*....|....*....|.
gi 2217285481 117 SLSIEETNKLRAKLGLKPLEV 137
Cdd:pfam19252   2 SLSIEETNKLRASLGLKPIPV 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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